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Signal standardization #10

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bvenn opened this issue Nov 30, 2022 · 0 comments
Open

Signal standardization #10

bvenn opened this issue Nov 30, 2022 · 0 comments

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@bvenn
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bvenn commented Nov 30, 2022

When handling time series, would it be beneficial to standardize the signals prior to TMEA (e.g. log2 fold changes regarding the first time point)!?

I think in unnormalized data an amplitude change of 21 -> 23 has the same impact as a change from 1 -> 3, whereas the latter could be weighted more to better reflect biological relevance.

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