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mtreeset.cpp
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mtreeset.cpp
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/***************************************************************************
* Copyright (C) 2006 by BUI Quang Minh, Steffen Klaere, Arndt von Haeseler *
* *
* This program is free software; you can redistribute it and/or modify *
* it under the terms of the GNU General Public License as published by *
* the Free Software Foundation; either version 2 of the License, or *
* (at your option) any later version. *
* *
* This program is distributed in the hope that it will be useful, *
* but WITHOUT ANY WARRANTY; without even the implied warranty of *
* MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the *
* GNU General Public License for more details. *
* *
* You should have received a copy of the GNU General Public License *
* along with this program; if not, write to the *
* Free Software Foundation, Inc., *
* 59 Temple Place - Suite 330, Boston, MA 02111-1307, USA. *
***************************************************************************/
#include "mtreeset.h"
#include "alignment.h"
#include "gzstream.h"
MTreeSet::MTreeSet()
{
}
MTreeSet::MTreeSet(const char *userTreeFile, bool &is_rooted,
int burnin, int max_count, const char *tree_weight_file) {
init(userTreeFile, is_rooted, burnin, max_count, tree_weight_file);
}
void readIntVector(const char *file_name, int burnin, int max_count, IntVector &vec) {
cout << "Reading integer vector file " << file_name << " ..." << endl;
vec.clear();
try {
ifstream in;
in.exceptions(ios::failbit | ios::badbit);
in.open(file_name);
// remove the failbit
in.exceptions(ios::badbit);
for (; !in.eof();) {
int i;
if(!(in >> i)) break;
if (burnin > 0)
burnin--;
else if (max_count > 0) {
vec.push_back(i);
max_count--;
}
}
in.clear();
// set the failbit again
in.exceptions(ios::failbit | ios::badbit);
in.close();
} catch(ios::failure) {
outError(ERR_READ_INPUT);
}
}
void MTreeSet::init(const char *userTreeFile, bool &is_rooted, int burnin, int max_count,
const char *tree_weight_file, IntVector *weights, bool compressed)
{
readTrees(userTreeFile, is_rooted, burnin, max_count, weights, compressed);
checkConsistency();
if (tree_weight_file)
readIntVector(tree_weight_file, burnin, max_count, tree_weights);
/* else if (!weights)
tree_weights.resize(size(), 1);*/
if (size() != tree_weights.size())
outError("Tree file and tree weight file have different number of entries");
}
void MTreeSet::init(StringIntMap &treels, bool &is_rooted, IntVector &weights) {
//resize(treels.size(), NULL);
int count = 0;
//IntVector ok_trees;
//ok_trees.resize(treels.size(), 0);
//for (i = 0; i < trees_id.size(); i++) ok_trees[trees_id[i]] = 1;
for (StringIntMap::iterator it = treels.begin(); it != treels.end(); it++)
if (weights[it->second]) {
count++;
MTree *tree = newTree();
stringstream ss(it->first);
bool myrooted = is_rooted;
tree->readTree(ss, myrooted);
NodeVector taxa;
tree->getTaxa(taxa);
for (NodeVector::iterator taxit = taxa.begin(); taxit != taxa.end(); taxit++)
(*taxit)->id = atoi((*taxit)->name.c_str());
//at(it->second) = tree;
push_back(tree);
tree_weights.push_back(weights[it->second]);
//cout << "Tree " << it->second << ": ";
//tree->printTree(cout, WT_NEWLINE);
}
cout << count << " tree(s) converted" << endl;
//tree_weights.resize(size(), 1);
}
void MTreeSet::readTrees(const char *infile, bool &is_rooted, int burnin, int max_count,
IntVector *weights, bool compressed)
{
cout << "Reading tree(s) file " << infile << " ..." << endl;
int count, omitted;
/* IntVector ok_trees;
if (trees_id) {
int max_id = *max_element(trees_id->begin(), trees_id->end());
ok_trees.resize(max_id+1, 0);
for (IntVector::iterator it = trees_id->begin(); it != trees_id->end(); it++)
ok_trees[*it] = 1;
cout << "Restricting to " << trees_id->size() << " trees" << endl;
}*/
try {
istream *in;
if (compressed) in = new igzstream; else in = new ifstream;
in->exceptions(ios::failbit | ios::badbit);
if (compressed) ((igzstream*)in)->open(infile); else ((ifstream*)in)->open(infile);
if (burnin > 0) {
int cnt = 0;
while (cnt < burnin && !in->eof()) {
char ch;
(*in) >> ch;
if (ch == ';') cnt++;
}
cout << cnt << " beginning tree(s) discarded" << endl;
if (in->eof())
throw "Burnin value is too large.";
}
for (count = 1, omitted = 0; !in->eof() && count <= max_count; count++) {
if (!weights || weights->at(count-1)) {
//cout << "Reading tree " << count << " ..." << endl;
MTree *tree = newTree();
bool myrooted = is_rooted;
//tree->userFile = (char*) infile;
tree->readTree(*in, myrooted);
push_back(tree);
if (weights)
tree_weights.push_back(weights->at(count-1));
else tree_weights.push_back(1);
//cout << "Tree contains " << tree->leafNum - tree->rooted <<
//" taxa and " << tree->nodeNum-1-tree->rooted << " branches" << endl;
} else {
// omit the tree
//push_back(NULL);
//in->exceptions(ios::badbit);
while (!in->eof()) {
char ch;
if (!((*in) >> ch)) break;
if (ch == ';') break;
}
omitted++;
}
char ch;
in->exceptions(ios::goodbit);
(*in) >> ch;
if (in->eof()) break;
in->unget();
in->exceptions(ios::failbit | ios::badbit);
}
cout << size() << ((front()->rooted) ? " rooted" : " un-rooted") << " tree(s) loaded" << endl;
if (omitted) cout << omitted << " tree(s) omitted" << endl;
//in->exceptions(ios::failbit | ios::badbit);
if (compressed) ((igzstream*)in)->close(); else ((ifstream*)in)->close();
} catch (ios::failure) {
outError(ERR_READ_INPUT, infile);
} catch (const char* str) {
outError(str);
}
}
void MTreeSet::checkConsistency() {
if (empty())
return;
iterator it;
bool rooted = false;
int i;
bool first = true;
for (it = begin(), i = 0; it != end(); it++, i++)
if ((*it)) {
if (!first && (*it)->rooted != rooted) {
cout << i+1 << " " << (*it)->rooted << " " << rooted << endl;
outError("Rooted and unrooted trees are mixed up");
rooted = (*it)->rooted;
}
first = false;
}
NodeVector taxa1;
NodeVector::iterator it2;
first = true;
for (it = begin(); it != end(); it++) if (*it) {
MTree *tree = *it;
NodeVector taxa;
tree->getTaxa(taxa);
sort(taxa.begin(), taxa.end(), nodenamecmp);
for (it2 = taxa.begin(), i = 0; it2 != taxa.end(); it2++, i++)
(*it2)->id = i;
if (first ) {
taxa1 = taxa;
first = false;
} else {
// now check this tree with the first tree
if (tree->leafNum != taxa1.size())
outError("Tree has different number of taxa!");
for (it2 = taxa.begin(), i = 0; it2 != taxa.end(); it2++, i++) {
if ((*it2)->name != taxa1[i]->name)
outError("Tree has different taxa names!");
}
}
}
}
bool MTreeSet::isRooted() {
if (empty()) return false;
return (front()->rooted);
}
void MTreeSet::assignLeafID() {
for (iterator it = begin(); it != end(); it++)
(*it)->assignLeafID();
}
void MTreeSet::printTrees(const char *ofile, int brtype)
{
try {
ofstream out;
out.exceptions(ios::failbit | ios::badbit);
out.open(ofile);
printTrees(out, brtype);
out.close();
cout << "Tree(s) were printed to " << ofile << endl;
} catch (ios::failure) {
outError(ERR_WRITE_OUTPUT, ofile);
}
}
void MTreeSet::printTrees(ostream & out, int brtype) {
for (iterator it = begin(); it != end(); it++) {
(*it)->printTree(out, brtype);
out << endl;
}
}
void MTreeSet::convertSplits(SplitGraph &sg, double split_threshold, int weighting_type,
double weight_threshold)
{
SplitIntMap hash_ss;
/*
if (split_threshold == 0.0) {
convertSplits(sg, hash_ss, weighting_type, weight_threshold);
return;
}*/
//SplitGraph temp;
convertSplits(sg, hash_ss, weighting_type, weight_threshold);
int nsplits = sg.getNSplits();
double threshold = split_threshold * size();
int count=0;
for (SplitGraph::iterator it = sg.begin(); it != sg.end(); ) {
count++;
//SplitIntMap::iterator ass_it = hash_ss.find(*it);
int freq_value;
Split *sp = hash_ss.findSplit(*it, freq_value);
assert(sp != NULL);
assert(*sp == *(*it));
//Split *sp = ass_it->first;
if (freq_value <= threshold) {
if (verbose_mode == VB_DEBUG) {
sp->report(cout);
}
int num = hash_ss.getValue(sg.back());
hash_ss.eraseSplit(sp);
if (it != sg.end()-1) {
hash_ss.eraseSplit(sg.back());
*(*it) = (*sg.back());
}
delete sg.back();
sg.pop_back();
if (it == sg.end()) break;
hash_ss.insertSplit(*it, num);
} else {
//sg.push_back(new Split(*sp));
it++;
}
}
/*
sg.taxa = temp.taxa;
sg.splits = temp.splits;
sg.pda = temp.pda;
sg.sets = temp.sets;
sg.trees = temp.trees;
temp.taxa = NULL;
temp.splits = NULL;
temp.pda = NULL;
temp.sets = NULL;
temp.trees = NULL;
*/
cout << nsplits - sg.getNSplits() << " split(s) discarded because frequency <= " << split_threshold << endl;
}
void MTreeSet::convertSplits(SplitGraph &sg, SplitIntMap &hash_ss,
int weighting_type, double weight_threshold) {
vector<string> taxname(front()->leafNum);
// make sure that the split system contains at least 1 split
if (size() == 0)
return;
front()->getTaxaName(taxname);
convertSplits(taxname, sg, hash_ss, weighting_type, weight_threshold);
}
void MTreeSet::convertSplits(vector<string> &taxname, SplitGraph &sg, SplitIntMap &hash_ss,
int weighting_type, double weight_threshold, bool sort_taxa) {
#ifdef USE_HASH_MAP
cout << "Using hash_map" << endl;
#else
cout << "Using map" << endl;
#endif
cout << "Converting collection of tree(s) into split system..." << endl;
SplitGraph::iterator itg;
vector<string>::iterator its;
/*
for (its = taxname.begin(); its != taxname.end(); its++)
if (*its == ROOT_NAME) {
taxname.erase(its);
break;
}*/
if (sort_taxa) sort(taxname.begin(), taxname.end());
sg.createBlocks();
for (its = taxname.begin(); its != taxname.end(); its++)
sg.getTaxa()->AddTaxonLabel(NxsString(its->c_str()));
/*
if (size() == 1 && weighting_type != SW_COUNT) {
front()->convertSplits(taxname, sg);
return;
}*/
SplitGraph *isg;
int tree_id = 0;
for (iterator it = begin(); it != end(); it++, tree_id++) {
if (tree_weights[tree_id] == 0) continue;
MTree *tree = *it;
if (tree->leafNum != taxname.size())
outError("Tree has different number of taxa!");
if (sort_taxa) {
NodeVector taxa;
tree->getTaxa(taxa);
sort(taxa.begin(), taxa.end(), nodenamecmp);
int i = 0;
for (NodeVector::iterator it2 = taxa.begin(); it2 != taxa.end(); it2++) {
if ((*it2)->name != taxname[i])
outError("Tree has different taxa names!");
(*it2)->id = i++;
}
}
isg = new SplitGraph();
tree->convertSplits(taxname, *isg);
//isg->getTaxa()->Report(cout);
//isg->report(cout);
for (itg = isg->begin(); itg != isg->end(); itg++) {
//SplitIntMap::iterator ass_it = hash_ss.find(*itg);
int value;
//if ((*itg)->getWeight()==0.0) cout << "zero weight!" << endl;
Split *sp = hash_ss.findSplit(*itg, value);
if (sp != NULL) {
//Split *sp = ass_it->first;
if (weighting_type != SW_COUNT)
sp->setWeight(sp->getWeight() + (*itg)->getWeight() * tree_weights[tree_id]);
else
sp->setWeight(sp->getWeight() + tree_weights[tree_id]);
hash_ss.setValue(sp, value + tree_weights[tree_id]);
}
else {
sp = new Split(*(*itg));
if (weighting_type != SW_COUNT)
sp->setWeight((*itg)->getWeight() * tree_weights[tree_id]);
else
sp->setWeight(tree_weights[tree_id]);
sg.push_back(sp);
//SplitIntMap::value_type spair(sp, 1);
//hash_ss.insert(spair);
hash_ss.insertSplit(sp, tree_weights[tree_id]);
}
}
if (size() == 1)
sg.splits->cycle = isg->splits->cycle;
delete isg;
}
int discarded = 0;
for (itg = sg.begin(); itg != sg.end(); ) {
if ((*itg)->getWeight() <= weight_threshold) {
discarded++;
delete (*itg);
(*itg) = sg.back();
sg.pop_back();
} else itg++;
}
if (discarded)
cout << discarded << " split(s) discarded because weight <= " << weight_threshold << endl;
//sg.report(cout);
}
MTreeSet::~MTreeSet()
{
for (reverse_iterator it = rbegin(); it != rend(); it++) {
MTree *tree = *it;
delete tree;
}
clear();
}
void MTreeSet::computeRFDist(int *rfdist, int mode, double weight_threshold) {
// exit if less than 2 trees
if (size() < 2)
return;
#ifdef USE_HASH_MAP
cout << "Using hash_map" << endl;
#else
cout << "Using map" << endl;
#endif
cout << "Computing Robinson-Foulds distance..." << endl;
vector<string> taxname(front()->leafNum);
vector<SplitIntMap*> hs_vec;
vector<SplitGraph*> sg_vec;
front()->getTaxaName(taxname);
// converting trees into split system then stored in SplitIntMap for efficiency
for (iterator it = begin(); it != end(); it++) {
SplitGraph *sg = new SplitGraph();
SplitIntMap *hs = new SplitIntMap();
(*it)->convertSplits(taxname, *sg);
// make sure that taxon 0 is included
for (SplitGraph::iterator sit = sg->begin(); sit != sg->end(); sit++) {
if (!(*sit)->containTaxon(0)) (*sit)->invert();
hs->insertSplit((*sit), 1);
}
hs_vec.push_back(hs);
sg_vec.push_back(sg);
}
// now start the RF computation
int id = 0;
for (vector<SplitIntMap*>::iterator hsit = hs_vec.begin(); hsit+1 != hs_vec.end(); hsit++, id++) {
vector<SplitIntMap*>::iterator end_it = hs_vec.end();
if (mode == RF_ADJACENT_PAIR) end_it = hsit+2;
int id2 = id+1;
for (vector<SplitIntMap*>::iterator hsit2 = hsit+1; hsit2 != end_it; hsit2++, id2++) {
int diff_splits = 0;
SplitIntMap::iterator spit;
for (spit = (*hsit2)->begin(); spit != (*hsit2)->end(); spit++) {
if (spit->first->getWeight() >= weight_threshold && !(*hsit)->findSplit(spit->first)) diff_splits++;
}
for (spit = (*hsit)->begin(); spit != (*hsit)->end(); spit++) {
if (spit->first->getWeight() >= weight_threshold && !(*hsit2)->findSplit(spit->first)) diff_splits++;
}
//int rf_val = (*hsit)->size() + (*hsit2)->size() - 2*common_splits;
int rf_val = diff_splits;
if (mode == RF_ADJACENT_PAIR)
rfdist[id] = rf_val;
else {
rfdist[id*size() + id2] = rfdist[id2*size() + id] = rf_val;
}
}
}
// delete memory
for (id = size()-1; id >= 0; id--) {
delete hs_vec[id];
delete sg_vec[id];
}
}
void MTreeSet::computeRFDist(int *rfdist, MTreeSet *treeset2,
const char *info_file, const char *tree_file, int *incomp_splits)
{
// exit if less than 2 trees
#ifdef USE_HASH_MAP
cout << "Using hash_map" << endl;
#else
cout << "Using map" << endl;
#endif
ofstream oinfo;
ofstream otree;
if (info_file) oinfo.open(info_file);
if (tree_file) otree.open(tree_file);
if (incomp_splits) memset(incomp_splits, 0, size()*treeset2->size()*sizeof(int));
vector<string> taxname(front()->leafNum);
vector<SplitIntMap*> hs_vec;
vector<SplitGraph*> sg_vec;
vector<NodeVector> nodes_vec;
front()->getTaxaName(taxname);
iterator it;
// converting trees into split system then stored in SplitIntMap for efficiency
for (iterator it = begin(); it != end(); it++) {
SplitGraph *sg = new SplitGraph();
SplitIntMap *hs = new SplitIntMap();
NodeVector nodes;
(*it)->convertSplits(taxname, *sg, &nodes);
// make sure that taxon 0 is included
int i = 0;
for (SplitGraph::iterator sit = sg->begin(); sit != sg->end(); sit++, i++) {
if (!(*sit)->containTaxon(0)) (*sit)->invert();
hs->insertSplit((*sit), i);
}
hs_vec.push_back(hs);
sg_vec.push_back(sg);
nodes_vec.push_back(nodes);
}
// converting trees into split system then stored in SplitIntMap for efficiency
for (it = treeset2->begin(); it != treeset2->end(); it++) {
SplitGraph *sg = new SplitGraph();
SplitIntMap *hs = new SplitIntMap();
NodeVector nodes;
(*it)->convertSplits(taxname, *sg, &nodes);
// make sure that taxon 0 is included
int i = 0;
for (SplitGraph::iterator sit = sg->begin(); sit != sg->end(); sit++, i++) {
if (!(*sit)->containTaxon(0)) (*sit)->invert();
hs->insertSplit((*sit), i);
}
hs_vec.push_back(hs);
sg_vec.push_back(sg);
nodes_vec.push_back(nodes);
}
// now start the RF computation
int id = 0;
int col_size = hs_vec.size() - size();
for (vector<SplitGraph*>::iterator hsit = sg_vec.begin(); id < size(); hsit++, id++) {
int id2 = 0;
for (vector<SplitIntMap*>::iterator hsit2 = (hs_vec.begin() + size()); hsit2 != hs_vec.end(); hsit2++, id2++) {
int common_splits = 0;
int i = 0;
for (SplitGraph::iterator spit = (*hsit)->begin(); spit != (*hsit)->end(); spit++, i++) {
if ((*hsit2)->findSplit(*spit)) {
common_splits++;
if (info_file && (*spit)->trivial()<0) oinfo << " " << nodes_vec[id][i]->name;
} else {
if (info_file && (*spit)->trivial()<0) oinfo << " -" << nodes_vec[id][i]->name;
nodes_vec[id][i]->name = "-" + nodes_vec[id][i]->name;
/*if (incomp_splits && !sg_vec[id2+size()]->compatible(*spit))
nodes_vec[id][i]->name = "-" + nodes_vec[id][i]->name;*/
}
}
int rf_val = (*hsit)->size() + (*hsit2)->size() - 2*common_splits;
rfdist[id*col_size + id2] = rf_val;
if (info_file) oinfo << endl;
if (tree_file) { at(id)->printTree(otree); otree << endl; }
for (i = 0; i < nodes_vec[id].size(); i++)
if (nodes_vec[id][i]->name[0] == '-') nodes_vec[id][i]->name.erase(0,1);
}
if (!incomp_splits) continue;
id2 = 0;
// count incompatible splits
for (vector<SplitGraph*>::iterator hsit3 = sg_vec.begin()+size(); hsit3 != sg_vec.end(); hsit3++, id2++) {
int num_incomp = 0;
SplitGraph::iterator spit;
for (spit = (*hsit)->begin(); spit != (*hsit)->end(); spit++)
if (!(*hsit3)->compatible(*spit)) num_incomp++;
for (spit = (*hsit3)->begin(); spit != (*hsit3)->end(); spit++)
if (!(*hsit)->compatible(*spit)) num_incomp++;
incomp_splits[id*col_size + id2] = num_incomp;
}
}
// delete memory
for (id = hs_vec.size()-1; id >= 0; id--) {
delete hs_vec[id];
delete sg_vec[id];
}
if (info_file) {
oinfo.close();
cout << "Detailed split occurences printed to " << info_file << endl;
}
if (tree_file) {
otree.close();
cout << "Detailed split occurences on tree printed to " << tree_file << endl;
}
}
int MTreeSet::sumTreeWeights() {
int sum = 0;
for (IntVector::iterator it = tree_weights.begin(); it != tree_weights.end(); it++)
sum += (*it);
return sum;
}
int MTreeSet::categorizeDistinctTrees(IntVector &category) {
if (empty()) return 0;
if (size() == 1) {
category.resize(1,0);
return 1;
}
StringIntMap tree_cat_map;
string root_name = front()->root->name;
int ncat = 0;
category.resize(size(),-1);
int id = 0;
for (iterator it = begin(); it != end(); it++, id++) {
(*it)->root = (*it)->findNodeName(root_name);
if (!(*it)->root || !(*it)->root->isLeaf())
outError("Internal error ", __func__);
stringstream ostr;
(*it)->printTree(ostr, WT_TAXON_ID | WT_SORT_TAXA);
string str = ostr.str();
//cout << str << endl;
StringIntMap::iterator map_it = tree_cat_map.find(str);
if (map_it == tree_cat_map.end()) { // not found
category[id] = ncat;
tree_cat_map[str] = ncat;
ncat++;
} else {
category[id] = map_it->second;
}
}
return ncat;
}
/*int MTreeSet::categorizeDistinctTrees(IntVector &category) {
// exit if less than 2 trees
if (empty()) return 0;
if (size() == 1) {
category.resize(1,0);
return 1;
}
#ifdef USE_HASH_MAP
cout << "Using hash_map" << endl;
#else
cout << "Using map" << endl;
#endif
cout << "Checking duplicated trees..." << endl;
vector<string> taxname(front()->leafNum);
vector<SplitIntMap*> hs_vec;
vector<SplitGraph*> sg_vec;
front()->getTaxaName(taxname);
// converting trees into split system then stored in SplitIntMap for efficiency
for (iterator it = begin(); it != end(); it++) {
SplitGraph *sg = new SplitGraph();
SplitIntMap *hs = new SplitIntMap();
(*it)->convertSplits(taxname, *sg);
// make sure that taxon 0 is included
for (SplitGraph::iterator sit = sg->begin(); sit != sg->end(); sit++) {
if (!(*sit)->containTaxon(0)) (*sit)->invert();
hs->insertSplit((*sit), 1);
}
hs_vec.push_back(hs);
sg_vec.push_back(sg);
}
// now start the RF computation
int id = 0, ncat = 0;
category.resize(size(),-1);
for (vector<SplitIntMap*>::iterator hsit = hs_vec.begin(); hsit != hs_vec.end(); hsit++, id++)
if (category[id] < 0) {
category[id] = ncat;
int id2 = id+1;
for (vector<SplitIntMap*>::iterator hsit2 = hsit+1; hsit2 != hs_vec.end(); hsit2++, id2++)
if (category[id2] < 0) {
bool equal = true;
for (SplitIntMap::iterator spit = (*hsit2)->begin(); spit != (*hsit2)->end(); spit++) {
if (!(*hsit)->findSplit(spit->first)) { equal = false; break; }
}
if (equal) category[id2] = ncat;
}
ncat++;
}
// delete memory
for (id = size()-1; id >= 0; id--) {
delete hs_vec[id];
delete sg_vec[id];
}
return ncat;
}
*/