diff --git a/include/nrf_rpc/nrf_rpc_uart.h b/include/nrf_rpc/nrf_rpc_uart.h
index 5f0a037dacaf..ec265dafd2bd 100644
--- a/include/nrf_rpc/nrf_rpc_uart.h
+++ b/include/nrf_rpc/nrf_rpc_uart.h
@@ -39,6 +39,9 @@ typedef struct nrf_rpc_uart {
 	hdlc_state_t hdlc_state;
 	uint8_t frame_buffer[NRF_RPC_MAX_FRAME_SIZE];
 	size_t frame_len;
+
+	/* UART send semaphore */
+	struct k_sem uart_tx_sem;
 } nrf_rpc_uart;
 
 extern const struct nrf_rpc_tr_api nrf_rpc_uart_service_api;
diff --git a/subsys/bluetooth/rpc/common/bt_rpc_common.c b/subsys/bluetooth/rpc/common/bt_rpc_common.c
index 74d29dddd79e..9613af6e03c7 100644
--- a/subsys/bluetooth/rpc/common/bt_rpc_common.c
+++ b/subsys/bluetooth/rpc/common/bt_rpc_common.c
@@ -25,9 +25,9 @@ BUILD_ASSERT(!IS_ENABLED(CONFIG_BT_BREDR), "BT_RPC does not support BR/EDR");
 #if CONFIG_NRF_RPC_IPC_SERVICE
 NRF_RPC_IPC_TRANSPORT(bt_rpc_tr, DEVICE_DT_GET(DT_NODELABEL(ipc0)), "bt_rpc_ept");
 #elif CONFIG_NRF_RPC_UART_TRANSPORT
-NRF_RPC_UART_TRANSPORT(bt_rpc_tr, DEVICE_DT_GET(DT_NODELABEL(uart1)));
+NRF_RPC_UART_TRANSPORT(rpc_tr, DEVICE_DT_GET(DT_NODELABEL(uart1)));
 #endif
-NRF_RPC_GROUP_DEFINE(bt_rpc_grp, "bt_rpc", &bt_rpc_tr, NULL, NULL, NULL);
+NRF_RPC_GROUP_DEFINE(bt_rpc_grp, "bt_rpc", &rpc_tr, NULL, NULL, NULL);
 
 enum {
 	CHECK_ENTRY_FLAGS,
diff --git a/subsys/net/openthread/rpc/common/ot_rpc_group.c b/subsys/net/openthread/rpc/common/ot_rpc_group.c
index 82a56e36f47e..729adc8e062a 100644
--- a/subsys/net/openthread/rpc/common/ot_rpc_group.c
+++ b/subsys/net/openthread/rpc/common/ot_rpc_group.c
@@ -15,10 +15,12 @@
 
 #if CONFIG_NRF_RPC_IPC_SERVICE
 NRF_RPC_IPC_TRANSPORT(ot_group_tr, DEVICE_DT_GET(DT_NODELABEL(ipc0)), "ot_rpc_ept");
-#elif CONFIG_NRF_RPC_UART_TRANSPORT
-NRF_RPC_UART_TRANSPORT(ot_group_tr, DEVICE_DT_GET(DT_NODELABEL(uart1)));
+#elif CONFIG_NRF_RPC_UART_TRANSPORT && !CONFIG_BT_RPC
+NRF_RPC_UART_TRANSPORT(rpc_tr, DEVICE_DT_GET(DT_NODELABEL(uart1)));
+#elif CONFIG_NRF_RPC_UART_TRANSPORT && CONFIG_BT_RPC
+extern const struct nrf_rpc_tr rpc_tr;
 #endif
-NRF_RPC_GROUP_DEFINE(ot_group, "ot", &ot_group_tr, NULL, NULL, NULL);
+NRF_RPC_GROUP_DEFINE(ot_group, "ot", &rpc_tr, NULL, NULL, NULL);
 LOG_MODULE_REGISTER(ot_rpc, LOG_LEVEL_DBG);
 
 #ifdef CONFIG_OPENTHREAD_RPC_INITIALIZE_NRF_RPC
diff --git a/subsys/nrf_rpc/nrf_rpc_uart.c b/subsys/nrf_rpc/nrf_rpc_uart.c
index 82d5369933a5..2b3359e7c7ce 100644
--- a/subsys/nrf_rpc/nrf_rpc_uart.c
+++ b/subsys/nrf_rpc/nrf_rpc_uart.c
@@ -115,6 +115,11 @@ static int init(const struct nrf_rpc_tr *transport, nrf_rpc_tr_receive_handler_t
 {
 	struct nrf_rpc_uart *uart_tr = transport->ctx;
 
+	if(uart_tr->transport != NULL) {
+		LOG_DBG("init not needed");
+		return 0;
+	}
+
 	uart_tr->transport = transport;
 
 	LOG_DBG("init called");
@@ -145,6 +150,8 @@ static int init(const struct nrf_rpc_tr *transport, nrf_rpc_tr_receive_handler_t
 		return 0;
 	}
 
+	k_sem_init(&uart_tr->uart_tx_sem, 1, 1);
+
 	k_work_init(&uart_tr->cb_work, work_handler);
 	ring_buf_init(&uart_tr->rx_ringbuf, sizeof(uart_tr->rx_buffer), uart_tr->rx_buffer);
 	uart_tr->hdlc_state = hdlc_state_unsync;
@@ -159,7 +166,7 @@ static int send(const struct nrf_rpc_tr *transport, const uint8_t *data, size_t
 	LOG_HEXDUMP_DBG(data, length, "Sending frame");
 	struct nrf_rpc_uart *uart_tr = transport->ctx;
 	// uint16_t crc;
-
+	k_sem_take(&uart_tr->uart_tx_sem, K_FOREVER);
 	// crc = crc16_ccitt(0xffff, data, length);
 	uart_poll_out(uart_tr->uart, hdlc_char_delimiter);
 
@@ -179,6 +186,7 @@ static int send(const struct nrf_rpc_tr *transport, const uint8_t *data, size_t
 	uart_poll_out(uart_tr->uart, hdlc_char_delimiter);
 
 	k_free((void*)data);
+	k_sem_give(&uart_tr->uart_tx_sem);
 
 	return 0;
 }