Strong: ≥5-fold increase in the plasma AUC values (>80% decrease in clearance)
Moderate: ≥2-fold increase in the plasma AUC values (50–80% decrease in clearance)
Weak: ≥1.25-fold and <2-fold increase in the plasma AUC values (20–50% decrease in clearance)
- fluvoxamine
- liquorice
- fluoroquinolones
- enoxacin
- ciprofloxacin
- verapamil
- St. John's wort
- methoxsalen
- mexiletine
- oral contraceptives
- acyclovir
- allopurinol
- mexiletine
- cimetidine
- caffeine
- echinacea
- peginterferon alpha-2a
- theophylline
- piperine
- zileuton
- interferon
- mibefradil
- grapefruit juice
- cumin
- turmeric
- isoniazid
- tetrahydropalmatine
- cannabidiol