web_scrapping_EMA.ipynb

{
 "cells": [
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# Data Scrapping form the European Medicines Agency (EMA)\n",
    "## *Miquel Anglada Girotto*\n",
    "\n",
    "In this notebook, I exemplify how the European Medicines Agency (EMA) web page can be scrapped to retrieve information from 1995 to 2018. Then, I performed exploratory data analysis on the downloaded dataset to carry out a personal analysis of pharmaceutical development in Europe."
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Load required dependencies"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 132,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    }
   },
   "outputs": [],
   "source": [
    "# libraries\n",
    "library(RSelenium)\n",
    "library(stringr)\n",
    "\n",
    "# self-made package\n",
    "source(\"EMA_webScrapping.R\")"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Set parameters"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    }
   },
   "outputs": [],
   "source": [
    "# start automated navigator\n",
    "initRSelenium()\n",
    "\n",
    "# Navigate to a list of all drugs\n",
    "url = \"https://www.ema.europa.eu/medicines/field_ema_web_categories%253Aname_field/Human/ema_group_types/ema_medicine\"\n",
    "remDr$navigate(url)\n",
    "\n",
    "# Define pages to look through\n",
    "page <- \"https://www.ema.europa.eu/en/medicines/field_ema_web_categories%253Aname_field/Human/ema_group_types/ema_medicine?page=\" #link to navigate through each page of the list.\n",
    "n <- as.character(round(1495/25)-1) #no. of pages to navigate, as.character() to allow pasting with the 'page' string."
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Download information from each drug"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    }
   },
   "outputs": [],
   "source": [
    "# Obtain each drug's link\n",
    "drug_links = getURLs(page,n)\n",
    "\n",
    "# Use drug links to retrieve information from EMA's webpage for each drug\n",
    "# (Slow)\n",
    "drugsDB = getDrugInfo(drug_links)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Save information in spreadsheet"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    }
   },
   "outputs": [],
   "source": [
    "# reshape dataframe and fill when features available\n",
    "drug_df = processTable(drugsDB)\n",
    "\n",
    "# save\n",
    "file_name = \"drug_df_EMA.csv\"\n",
    "#saveTable(drug_df,file_name)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# Exploratory Data Analysis\n",
    "\n",
    "The \"scrapped dataset\" contains 1272 columns and 20 fields that describe each of the drugs registered in the EMA, approved or rejected.\n",
    "\n",
    "To further study available data I subsetted `drug_df` into `df` with fewer columns and easy-to-work-with names."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 27,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    }
   },
   "outputs": [],
   "source": [
    "# load\n",
    "drug_df = read.table('drug_df_EMA.csv',sep=',',header=T,stringsAsFactors = F)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 28,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    }
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "'Total EMA registered drugs: 1272'"
      ],
      "text/latex": [
       "'Total EMA registered drugs: 1272'"
      ],
      "text/markdown": [
       "'Total EMA registered drugs: 1272'"
      ],
      "text/plain": [
       "[1] \"Total EMA registered drugs: 1272\""
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "text/html": [
       "'Table fields:'"
      ],
      "text/latex": [
       "'Table fields:'"
      ],
      "text/markdown": [
       "'Table fields:'"
      ],
      "text/plain": [
       "[1] \"Table fields:\""
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      " [1] \"Name\"                                                                        \n",
      " [2] \"Agency.product.number\"                                                       \n",
      " [3] \"Active.substance\"                                                            \n",
      " [4] \"International.non.proprietary.name..INN..or.common.name\"                     \n",
      " [5] \"Therapeutic.area..MeSH.\"                                                     \n",
      " [6] \"Anatomical.therapeutic.chemical..ATC..code\"                                  \n",
      " [7] \"Generic\"                                                                     \n",
      " [8] \"Marketing.authorisation.holder\"                                              \n",
      " [9] \"Revision\"                                                                    \n",
      "[10] \"Date.of.issue.of.marketing.authorisation.valid.throughout.the.European.Union\"\n",
      "[11] \"Contact.address\"                                                             \n",
      "[12] \"Additional.monitoring\"                                                       \n",
      "[13] \"Orphan\"                                                                      \n",
      "[14] \"Conditional.approval\"                                                        \n",
      "[15] \"Biosimilar\"                                                                  \n",
      "[16] \"Marketing.autorisation.applicant\"                                            \n",
      "[17] \"Date.of.opinion\"                                                             \n",
      "[18] \"Exceptional.circumstances\"                                                   \n",
      "[19] \"Date.of.refusal.of.marketing.authorisation\"                                  \n",
      "[20] \"Countries\"                                                                   \n"
     ]
    }
   ],
   "source": [
    "# Number of registered drugs\n",
    "paste('Total EMA registered drugs:',nrow(drug_df))\n",
    "\n",
    "# Fields names\n",
    "\"Table fields:\"\n",
    "print(colnames(drug_df))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 29,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    }
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "[1] \"The clean dataframe has  1272 entries.\"\n"
     ]
    },
    {
     "data": {
      "text/html": [
       "<table>\n",
       "<caption>A data.frame: 6 × 11</caption>\n",
       "<thead>\n",
       "\t<tr><th scope=col>Name</th><th scope=col>substance_act</th><th scope=col>substance_inn</th><th scope=col>Generic</th><th scope=col>Orphan</th><th scope=col>Dates</th><th scope=col>Years</th><th scope=col>ex_circ</th><th scope=col>Countries</th><th scope=col>mah</th><th scope=col>mesh</th></tr>\n",
       "\t<tr><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;lgl[,1]&gt;</th><th scope=col>&lt;lgl[,1]&gt;</th><th scope=col>&lt;dttm&gt;</th><th scope=col>&lt;I&lt;chr&gt;&gt;</th><th scope=col>&lt;lgl[,1]&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "\t<tr><td>Bortezomib Sun             </td><td>bortezomib   </td><td>bortezomib   </td><td> TRUE</td><td>FALSE</td><td>2016-07-22</td><td>2016</td><td>FALSE</td><td>The Netherlands</td><td>SUN Pharmaceutical Industries (Europe) B.V.</td><td>Multiple Myeloma                                                                                                                                                                              </td></tr>\n",
       "\t<tr><td>Verzenios                  </td><td>abemaciclib  </td><td>abemaciclib  </td><td>FALSE</td><td>FALSE</td><td>2018-09-26</td><td>2018</td><td>FALSE</td><td>The Netherlands</td><td>Eli Lilly Nederland B.V.                   </td><td>Breast Neoplasms                                                                                                                                                                              </td></tr>\n",
       "\t<tr><td>Orgalutran                 </td><td>ganirelix    </td><td>ganirelix    </td><td>FALSE</td><td>FALSE</td><td>2000-05-16</td><td>2000</td><td>FALSE</td><td>The Netherlands</td><td>Merck Sharp and Dohme B.V                  </td><td>Reproductive Techniques, Assisted\n",
       "Ovulation Induction                                                                                                                                        </td></tr>\n",
       "\t<tr><td>Aldurazyme                 </td><td>laronidase   </td><td>laronidase   </td><td>FALSE</td><td> TRUE</td><td>2003-06-09</td><td>2003</td><td>FALSE</td><td>The Netherlands</td><td>Genzyme Europe B.V.                        </td><td>Mucopolysaccharidosis I                                                                                                                                                                       </td></tr>\n",
       "\t<tr><td>Imatinib Accord            </td><td>imatinib     </td><td>imatinib     </td><td> TRUE</td><td>FALSE</td><td>2013-06-30</td><td>2013</td><td>FALSE</td><td>United Kingdom </td><td>Accord Healthcare Ltd                      </td><td>Precursor Cell Lymphoblastic Leukemia-Lymphoma\n",
       "Dermatofibrosarcoma\n",
       "Myelodysplastic-Myeloproliferative Diseases\n",
       "Leukemia, Myelogenous, Chronic, BCR-ABL Positive\n",
       "Hypereosinophilic Syndrome</td></tr>\n",
       "\t<tr><td>Levetiracetam Actavis Group</td><td>levetiracetam</td><td>levetiracetam</td><td> TRUE</td><td>FALSE</td><td>2011-12-04</td><td>2011</td><td>FALSE</td><td>Iceland        </td><td>Actavis Group PTC ehf                      </td><td>Epilepsy                                                                                                                                                                                      </td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "A data.frame: 6 × 11\n",
       "\\begin{tabular}{r|lllllllllll}\n",
       " Name & substance\\_act & substance\\_inn & Generic & Orphan & Dates & Years & ex\\_circ & Countries & mah & mesh\\\\\n",
       " <chr> & <chr> & <chr> & <lgl{[},1{]}> & <lgl{[},1{]}> & <dttm> & <I<chr>> & <lgl{[},1{]}> & <chr> & <chr> & <chr>\\\\\n",
       "\\hline\n",
       "\t Bortezomib Sun              & bortezomib    & bortezomib    &  TRUE & FALSE & 2016-07-22 & 2016 & FALSE & The Netherlands & SUN Pharmaceutical Industries (Europe) B.V. & Multiple Myeloma                                                                                                                                                                              \\\\\n",
       "\t Verzenios                   & abemaciclib   & abemaciclib   & FALSE & FALSE & 2018-09-26 & 2018 & FALSE & The Netherlands & Eli Lilly Nederland B.V.                    & Breast Neoplasms                                                                                                                                                                              \\\\\n",
       "\t Orgalutran                  & ganirelix     & ganirelix     & FALSE & FALSE & 2000-05-16 & 2000 & FALSE & The Netherlands & Merck Sharp and Dohme B.V                   & Reproductive Techniques, Assisted\n",
       "Ovulation Induction                                                                                                                                        \\\\\n",
       "\t Aldurazyme                  & laronidase    & laronidase    & FALSE &  TRUE & 2003-06-09 & 2003 & FALSE & The Netherlands & Genzyme Europe B.V.                         & Mucopolysaccharidosis I                                                                                                                                                                       \\\\\n",
       "\t Imatinib Accord             & imatinib      & imatinib      &  TRUE & FALSE & 2013-06-30 & 2013 & FALSE & United Kingdom  & Accord Healthcare Ltd                       & Precursor Cell Lymphoblastic Leukemia-Lymphoma\n",
       "Dermatofibrosarcoma\n",
       "Myelodysplastic-Myeloproliferative Diseases\n",
       "Leukemia, Myelogenous, Chronic, BCR-ABL Positive\n",
       "Hypereosinophilic Syndrome\\\\\n",
       "\t Levetiracetam Actavis Group & levetiracetam & levetiracetam &  TRUE & FALSE & 2011-12-04 & 2011 & FALSE & Iceland         & Actavis Group PTC ehf                       & Epilepsy                                                                                                                                                                                      \\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "A data.frame: 6 × 11\n",
       "\n",
       "| Name &lt;chr&gt; | substance_act &lt;chr&gt; | substance_inn &lt;chr&gt; | Generic &lt;lgl[,1]&gt; | Orphan &lt;lgl[,1]&gt; | Dates &lt;dttm&gt; | Years &lt;I&lt;chr&gt;&gt; | ex_circ &lt;lgl[,1]&gt; | Countries &lt;chr&gt; | mah &lt;chr&gt; | mesh &lt;chr&gt; |\n",
       "|---|---|---|---|---|---|---|---|---|---|---|\n",
       "| Bortezomib Sun              | bortezomib    | bortezomib    |  TRUE | FALSE | 2016-07-22 | 2016 | FALSE | The Netherlands | SUN Pharmaceutical Industries (Europe) B.V. | Multiple Myeloma                                                                                                                                                                               |\n",
       "| Verzenios                   | abemaciclib   | abemaciclib   | FALSE | FALSE | 2018-09-26 | 2018 | FALSE | The Netherlands | Eli Lilly Nederland B.V.                    | Breast Neoplasms                                                                                                                                                                               |\n",
       "| Orgalutran                  | ganirelix     | ganirelix     | FALSE | FALSE | 2000-05-16 | 2000 | FALSE | The Netherlands | Merck Sharp and Dohme B.V                   | Reproductive Techniques, Assisted\n",
       "Ovulation Induction                                                                                                                                         |\n",
       "| Aldurazyme                  | laronidase    | laronidase    | FALSE |  TRUE | 2003-06-09 | 2003 | FALSE | The Netherlands | Genzyme Europe B.V.                         | Mucopolysaccharidosis I                                                                                                                                                                        |\n",
       "| Imatinib Accord             | imatinib      | imatinib      |  TRUE | FALSE | 2013-06-30 | 2013 | FALSE | United Kingdom  | Accord Healthcare Ltd                       | Precursor Cell Lymphoblastic Leukemia-Lymphoma\n",
       "Dermatofibrosarcoma\n",
       "Myelodysplastic-Myeloproliferative Diseases\n",
       "Leukemia, Myelogenous, Chronic, BCR-ABL Positive\n",
       "Hypereosinophilic Syndrome |\n",
       "| Levetiracetam Actavis Group | levetiracetam | levetiracetam |  TRUE | FALSE | 2011-12-04 | 2011 | FALSE | Iceland         | Actavis Group PTC ehf                       | Epilepsy                                                                                                                                                                                       |\n",
       "\n"
      ],
      "text/plain": [
       "  Name                        substance_act substance_inn Generic Orphan\n",
       "1 Bortezomib Sun              bortezomib    bortezomib     TRUE   FALSE \n",
       "2 Verzenios                   abemaciclib   abemaciclib   FALSE   FALSE \n",
       "3 Orgalutran                  ganirelix     ganirelix     FALSE   FALSE \n",
       "4 Aldurazyme                  laronidase    laronidase    FALSE    TRUE \n",
       "5 Imatinib Accord             imatinib      imatinib       TRUE   FALSE \n",
       "6 Levetiracetam Actavis Group levetiracetam levetiracetam  TRUE   FALSE \n",
       "  Dates      Years ex_circ Countries      \n",
       "1 2016-07-22 2016  FALSE   The Netherlands\n",
       "2 2018-09-26 2018  FALSE   The Netherlands\n",
       "3 2000-05-16 2000  FALSE   The Netherlands\n",
       "4 2003-06-09 2003  FALSE   The Netherlands\n",
       "5 2013-06-30 2013  FALSE   United Kingdom \n",
       "6 2011-12-04 2011  FALSE   Iceland        \n",
       "  mah                                        \n",
       "1 SUN Pharmaceutical Industries (Europe) B.V.\n",
       "2 Eli Lilly Nederland B.V.                   \n",
       "3 Merck Sharp and Dohme B.V                  \n",
       "4 Genzyme Europe B.V.                        \n",
       "5 Accord Healthcare Ltd                      \n",
       "6 Actavis Group PTC ehf                      \n",
       "  mesh                                                                                                                                                                                          \n",
       "1 Multiple Myeloma                                                                                                                                                                              \n",
       "2 Breast Neoplasms                                                                                                                                                                              \n",
       "3 Reproductive Techniques, Assisted\\nOvulation Induction                                                                                                                                        \n",
       "4 Mucopolysaccharidosis I                                                                                                                                                                       \n",
       "5 Precursor Cell Lymphoblastic Leukemia-Lymphoma\\nDermatofibrosarcoma\\nMyelodysplastic-Myeloproliferative Diseases\\nLeukemia, Myelogenous, Chronic, BCR-ABL Positive\\nHypereosinophilic Syndrome\n",
       "6 Epilepsy                                                                                                                                                                                      "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "# make new df with features of interest\n",
    "df = drug_df['Name']\n",
    "\n",
    "df['substance_act'] = drug_df['Active.substance']\n",
    "\n",
    "df['substance_inn'] = drug_df['International.non.proprietary.name..INN..or.common.name']\n",
    "\n",
    "df['Generic'] = drug_df['Generic']!=''\n",
    "\n",
    "df['Orphan'] = drug_df['Orphan']!=''\n",
    "\n",
    "df[['Dates']] = strptime(drug_df[['Date.of.issue.of.marketing.authorisation.valid.throughout.the.European.Union']], \"%d/%m/%Y\")\n",
    "df['Years'] = format(df['Dates'], \"%Y\")\n",
    "\n",
    "df['ex_circ'] = drug_df['Exceptional.circumstances']!=''\n",
    "\n",
    "df['Countries'] = drug_df['Countries']\n",
    "\n",
    "df['mah'] = drug_df['Marketing.authorisation.holder']\n",
    "\n",
    "df['mesh'] = drug_df['Therapeutic.area..MeSH.']\n",
    "\n",
    "# Data cleaning and wrangling\n",
    "#df = df[df$mah != '',]\n",
    "\n",
    "# check\n",
    "print(paste('The clean dataframe has ',nrow(df),'entries.'))\n",
    "head(df)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Therapeutic Areas\n",
    "\n",
    "### Which are the most common therapeutic areas?\n",
    "\n",
    "To start, we may compute the percentage of appearance of MeSH terms in drug indications to understand which therapeutic areas may hold most interest."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 84,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "'Diversity in therapeutic areas: 509'"
      ],
      "text/latex": [
       "'Diversity in therapeutic areas: 509'"
      ],
      "text/markdown": [
       "'Diversity in therapeutic areas: 509'"
      ],
      "text/plain": [
       "[1] \"Diversity in therapeutic areas: 509\""
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "text/html": [
       "'Top 10:'"
      ],
      "text/latex": [
       "'Top 10:'"
      ],
      "text/markdown": [
       "'Top 10:'"
      ],
      "text/plain": [
       "[1] \"Top 10:\""
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "text/plain": [
       "\n",
       "     Diabetes Mellitus, Type 2                 HIV Infections \n",
       "                    0.15839243                     0.14420804 \n",
       "                  Immunization                   Hypertension \n",
       "                    0.12056738                     0.10401891 \n",
       "              Breast Neoplasms          Myocardial Infarction \n",
       "                    0.09929078                     0.09456265 \n",
       "Carcinoma, Non-Small-Cell Lung          Arthritis, Rheumatoid \n",
       "                    0.09219858                     0.08510638 \n",
       "                        Cancer              Diabetes Mellitus \n",
       "                    0.08274232                     0.06855792 "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "text/html": [
       "'Last 10:'"
      ],
      "text/latex": [
       "'Last 10:'"
      ],
      "text/markdown": [
       "'Last 10:'"
      ],
      "text/plain": [
       "[1] \"Last 10:\""
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "text/plain": [
       "\n",
       "                Acromegaly                    Adenoma \n",
       "               0.002364066                0.002364066 \n",
       "Adenomatous Polyposis Coli   Adrenal Cortex Neoplasms \n",
       "               0.002364066                0.002364066 \n",
       "     Adrenal Insufficiency  Alcohol-Related Disorders \n",
       "               0.002364066                0.002364066 \n",
       "        alpha-Mannosidosis      Amyloidosis, Familial \n",
       "               0.002364066                0.002364066 \n",
       "   Anemia, Iron-Deficiency        Anemia, Sickle Cell \n",
       "               0.002364066                0.002364066 "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "# list drugs and their therapeutic area MeSH\n",
    "\n",
    "# split mesh terms\n",
    "list_mesh <- lapply(df$mesh,split=\"\\n\",strsplit)\n",
    "\n",
    "# add drug names\n",
    "attributes(list_mesh)$names <- drug_df$Name\n",
    "\n",
    "# compute total diversity\n",
    "paste('Diversity in therapeutic areas:',length(unique(list_mesh)))\n",
    "\n",
    "# compute frequency table of MeSH terms\n",
    "tab_mesh = table(unlist(list_mesh))\n",
    "tab_mesh = tab_mesh/length(tab_mesh)\n",
    "tab_mesh = sort(tab_mesh,decreasing = T)\n",
    "\n",
    "'Top 10:'\n",
    "sort(tab_mesh,decreasing = T)[1:10]\n",
    "\n",
    "'Last 10:'\n",
    "sort(tab_mesh,decreasing = F)[1:10]"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Most of the drugs developed target chronic diseases like diabetes, cancer, HIV or heart complications. The inability to find a cure to this diseases may explain why most of the companies decided to tackle them. However, data may also indicate, as spread throughout public opinion, that pharmaceutical investments could be biased towards chronic diseases because they guarantee a constant revenue.\n",
    "\n",
    "On the other side of the list, we find genetic and rare diseases (e.g. sickle cell anemia, acromegaly) that would require complex therapies."
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Approval evolution in therapeutic areas\n",
    "\n",
    "Drug development in certain areas may have had different evolution in the EMA. Below, I plotted the evolution of the number of approved drugs for each MeSH area."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 89,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    }
   },
   "outputs": [
    {
     "data": {
      "image/png": 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GlTU1PT+vXrr1y5Mjc3l2TlPek0S0R7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wqAjIwMX19fMxajF+YGEWmh+SO3fPnyL7/8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\nD6/FYw1999oTGw+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      "text/plain": [
       "Plot with title “Approved Drugs for\n",
       " Cancer”"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "# number of drugs per area per year\n",
    "n_areas = 10\n",
    "years = 1995:2018\n",
    "area_year = matrix(nrow=n_areas,ncol=length(years))\n",
    "rownames(area_year) = names(tab_mesh)[1:n_areas]\n",
    "colnames(area_year) = years\n",
    "\n",
    "for (area in names(tab_mesh)[1:n_areas]){\n",
    "    # find drug names that contain a certain \"area\"\n",
    "    idx_area = sapply(list_mesh,function(x){any(unlist(x) %in% area)})\n",
    "    # get year of each drug of the area\n",
    "    tmp_years = df[idx_area,'Years']\n",
    "    tmp_years = table(tmp_years[!is.na(tmp_years)])\n",
    "    # save\n",
    "    area_year[area, colnames(area_year) %in% names(tmp_years)] = tmp_years\n",
    "}\n",
    "area_year[is.na(area_year)] = 0\n",
    "\n",
    "# visualize\n",
    "options(repr.plot.width=9, repr.plot.height=7)\n",
    "\n",
    "par(mfrow=c(3,3))\n",
    "for (i in 1:length(tmp[1:n_countries])){\n",
    "    plot(as.numeric(colnames(area_year)),area_year[i,],main=paste('Approved Drugs for\\n',rownames(area_year)[i]),type='l',bty='n',xlab='Year',ylab='n_approved',col=i,lty=2,lwd=3,ylim=c(0,20))\n",
    "}"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "In most of the cases, the number of drugs approved every year is steady or increases towards the end probably thanks to new research insights.\n",
    "\n",
    "Interestingly, drugs for treating heart-related diseases (hypertension, myocardial infarction) show a clear peak between 2005 and 2010.\n",
    "In particular, the peak in myocardial infarction was related to the approval of 28 generic drugs based on the compound *clopidogrel*."
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Generics\n",
    "\n",
    "Generics are the low-cost versions of drugs that can be marketed when the marketing exclusivity of another drug expires.\n",
    "They can be sold at lower prices because they only need to perform safety trials."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 134,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    }
   },
   "outputs": [
    {
     "data": {
      "image/png": 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ylcWFjYn//857vvvttygAwLC5OHNX3c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\nAElFTkSuQmCC",
      "text/plain": [
       "Plot with title “Generics per drug”"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "# visualization\n",
    "options(repr.plot.width=10, repr.plot.height=4)\n",
    "par(mfrow=c(1,2))\n",
    "\n",
    "# Proportion of generics\n",
    "barplot(table(df['Generic']), main = 'EMA Generics',col=c('darkorange','darkblue'),names.arg = c('Not generic','Generic'))\n",
    "#legend('topright',legend = c('Not generic','Generic'),fill = c('darkorange','darkblue'))\n",
    "\n",
    "# Generics per drug\n",
    "tmp = table(df['substance_inn'])\n",
    "tmp = tmp[tmp!=1]\n",
    "gen_drug = tmp[order(tmp,decreasing=T)]\n",
    "hist(gen_drug, main = 'Generics per drug',col='darkblue', xlab='n generics / substance inn', xlim=c(2,max(gen_drug)))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 32,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    }
   },
   "outputs": [
    {
     "data": {
      "image/png": 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bAw6aPYoBydTicSL5KpcB5tXl6ewilqDZNuCG1sbJydnZs3b15io9CyZUsRuXjx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\nvUOagwAAAABJRU5ErkJggg==",
      "text/plain": [
       "Plot with title “Evolution of generics”"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "# visualization options\n",
    "options(repr.plot.width=10, repr.plot.height=3)\n",
    "\n",
    "# Evolution of generics\n",
    "tmp = table(df$Generic,df$Years)\n",
    "df.bar = barplot(tmp,col=c('darkorange','darkblue'),las=2, main='Evolution of generics')\n",
    "lines(df.bar,(tmp[2,]/colSums(tmp))*100,lty=2,lwd=3)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Generic drugs start appearing slowly after the approval of the equivalent non-generic drug. Surprisingly, there can be more than one generic per drug.\n",
    "\n",
    "As mentioned below, *clopidogrel* is the compound with more generics and had been object of patent infringement litigation ([ref](https://www.ft.com/content/20159dfe-2e50-11db-93ad-0000779e2340))."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 90,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    }
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "[1] \"clopidogrel is the drug with more generic versions, 28 in particular.\"\n",
      "[1] \"clopidogrel is indicated for Stroke\"                      \n",
      "[2] \"clopidogrel is indicated for Peripheral Vascular Diseases\"\n",
      "[3] \"clopidogrel is indicated for Myocardial Infarction\"       \n",
      "[4] \"clopidogrel is indicated for Acute Coronary Syndrome\"     \n",
      "[5] \"clopidogrel is indicated for Atrial Fibrillation\"         \n"
     ]
    }
   ],
   "source": [
    "# which one is the maximum?\n",
    "name_max = names(gen_drug)[1]\n",
    "print(paste(name_max,'is the drug with more generic versions,',gen_drug[1],'in particular.'))\n",
    "\n",
    "# which are its indications\n",
    "# get Name of non generic versions\n",
    "selected_drug_names = df[(df['substance_inn'] == name_max) & (df['Generic'] == F), 'Name']\n",
    "selected_indications = unique(unlist(list_mesh[selected_drug_names]))\n",
    "\n",
    "print(paste(name_max, 'is indicated for',selected_indications))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 34,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    },
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table>\n",
       "<caption>A data.frame: 28 × 11</caption>\n",
       "<thead>\n",
       "\t<tr><th></th><th scope=col>Name</th><th scope=col>substance_act</th><th scope=col>substance_inn</th><th scope=col>Generic</th><th scope=col>Orphan</th><th scope=col>Dates</th><th scope=col>Years</th><th scope=col>ex_circ</th><th scope=col>Countries</th><th scope=col>mah</th><th scope=col>mesh</th></tr>\n",
       "\t<tr><th></th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;lgl[,1]&gt;</th><th scope=col>&lt;lgl[,1]&gt;</th><th scope=col>&lt;dttm&gt;</th><th scope=col>&lt;I&lt;chr&gt;&gt;</th><th scope=col>&lt;lgl[,1]&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "\t<tr><th scope=row>124</th><td>Clopidogrel Apotex (previously Clopidogrel Mylan Pharma)</td><td>clopidogrel besilate         </td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2009-10-15</td><td>2009</td><td>FALSE</td><td>The Netherlands</td><td>Apotex Europe B.V.              </td><td>Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              </td></tr>\n",
       "\t<tr><th scope=row>390</th><td>Clopidogrel HCS                                         </td><td>clopidogrel hydrochloride    </td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2010-10-27</td><td>2010</td><td>FALSE</td><td>Belgium        </td><td>HCS bvba                        </td><td>Peripheral Vascular Diseases\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction\n",
       "Stroke                     </td></tr>\n",
       "\t<tr><th scope=row>517</th><td>Grepid                                                  </td><td>clopidogrel besilate         </td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2009-07-27</td><td>2009</td><td>FALSE</td><td>Greece         </td><td>Pharmathen S.A.                 </td><td>Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              </td></tr>\n",
       "\t<tr><th scope=row>543</th><td>Clopidogrel Zentiva (previously Clopidogrel Winthrop)   </td><td>clopidogrel                  </td><td>clopidogrel</td><td>FALSE</td><td>FALSE</td><td>2008-07-15</td><td>2008</td><td>FALSE</td><td>Czech Republic </td><td>Zentiva k.s.                    </td><td>Stroke\n",
       "Peripheral Vascular Diseases\n",
       "Myocardial Infarction\n",
       "Acute Coronary Syndrome                     </td></tr>\n",
       "\t<tr><th scope=row>580</th><td>Clopidogrel Mylan                                       </td><td>clopidogrel hydrochloride    </td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2009-09-20</td><td>2009</td><td>FALSE</td><td>France         </td><td>Mylan S.A.S.                    </td><td>Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              </td></tr>\n",
       "\t<tr><th scope=row>582</th><td>Clopidogrel Krka                                        </td><td>clopidogrel hydrochloride    </td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2009-09-22</td><td>2009</td><td>FALSE</td><td>Slovenia       </td><td>Krka, d.d., Novo mesto          </td><td>Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              </td></tr>\n",
       "\t<tr><th scope=row>585</th><td>Zyllt                                                   </td><td>clopidogrel hydrogen sulphate</td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2009-09-28</td><td>2009</td><td>FALSE</td><td>Slovenia       </td><td>Krka, d.d., Novo mesto          </td><td>Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction                     </td></tr>\n",
       "\t<tr><th scope=row>589</th><td>Clopidogrel TAD                                         </td><td>clopidogrel hydrochloride    </td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2009-09-22</td><td>2009</td><td>FALSE</td><td>Germany        </td><td>Tad Pharma GmbH                 </td><td>Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              </td></tr>\n",
       "\t<tr><th scope=row>607</th><td>Clopidogrel ratiopharm GmbH                             </td><td>clopidogrel                  </td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2009-07-27</td><td>2009</td><td>FALSE</td><td>Czech Republic </td><td>Archie Samiel s.r.o.            </td><td>Peripheral Vascular Diseases\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction\n",
       "Stroke                     </td></tr>\n",
       "\t<tr><th scope=row>609</th><td>Clopidogrel ratiopharm                                  </td><td>clopidogrel hydrogen sulphate</td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2015-02-18</td><td>2015</td><td>FALSE</td><td>The Netherlands</td><td>Teva B.V.                       </td><td>Myocardial Infarction\n",
       "Acute Coronary Syndrome\n",
       "Peripheral Vascular Diseases\n",
       "Stroke                     </td></tr>\n",
       "\t<tr><th scope=row>639</th><td>Plavix                                                  </td><td>clopidogrel hydrogen sulfate </td><td>clopidogrel</td><td>FALSE</td><td>FALSE</td><td>1998-07-15</td><td>1998</td><td>FALSE</td><td>France         </td><td>Sanofi Clir SNC                 </td><td>Stroke\n",
       "Peripheral Vascular Diseases\n",
       "Atrial Fibrillation\n",
       "Myocardial Infarction\n",
       "Acute Coronary Syndrome</td></tr>\n",
       "\t<tr><th scope=row>743</th><td>Iscover                                                 </td><td>clopidogrel                  </td><td>clopidogrel</td><td>FALSE</td><td>FALSE</td><td>1998-07-14</td><td>1998</td><td>FALSE</td><td>France         </td><td>Sanofi-Aventis Groupe           </td><td>Stroke\n",
       "Peripheral Vascular Diseases\n",
       "Atrial Fibrillation\n",
       "Myocardial Infarction\n",
       "Acute Coronary Syndrome</td></tr>\n",
       "\t<tr><th scope=row>793</th><td>Clopidogrel Teva (hydrogen sulphate)                    </td><td>clopidogrel hydrogen sulphate</td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2009-07-27</td><td>2009</td><td>FALSE</td><td>The Netherlands</td><td>Teva Pharma B.V.                </td><td>Acute Coronary Syndrome\n",
       "Peripheral Vascular Diseases\n",
       "Myocardial Infarction\n",
       "Stroke                     </td></tr>\n",
       "\t<tr><th scope=row>815</th><td>Clopidogrel Acino                                       </td><td>clopidogrel                  </td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2009-07-27</td><td>2009</td><td>FALSE</td><td>Germany        </td><td>Acino AG                        </td><td>Peripheral Vascular Diseases\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction\n",
       "Stroke                     </td></tr>\n",
       "\t<tr><th scope=row>855</th><td>Clopidogrel Teva Pharma (previously Clopidogrel HCS)    </td><td>clopidogrel hydrochloride    </td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2009-09-20</td><td>2009</td><td>FALSE</td><td>The Netherlands</td><td>Teva B.V.                       </td><td>Myocardial Infarction\n",
       "Peripheral Vascular Diseases\n",
       "Stroke                                              </td></tr>\n",
       "\t<tr><th scope=row>906</th><td>Clopidogrel BGR (previously Zylagren)                   </td><td>clopidogrel hydrogen sulphate</td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2009-09-20</td><td>2009</td><td>FALSE</td><td>France         </td><td>Biogaran                        </td><td>Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              </td></tr>\n",
       "\t<tr><th scope=row>915</th><td>Clopidogrel Krka d.d. (previously Zopya)                </td><td>clopidogrel hydrochloride    </td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2009-09-20</td><td>2009</td><td>FALSE</td><td>               </td><td>                                </td><td>                                                                                                         </td></tr>\n",
       "\t<tr><th scope=row>1067</th><td>Clopidogrel DURA                                        </td><td>clopidogrel hydrochloride    </td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2009-07-20</td><td>2009</td><td>FALSE</td><td>Germany        </td><td>Mylan dura GmbH                 </td><td>Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              </td></tr>\n",
       "\t<tr><th scope=row>1076</th><td>Clopidogrel Teva Pharma B.V.                            </td><td>clopidogrel hydrobromide     </td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2011-06-15</td><td>2011</td><td>FALSE</td><td>The Netherlands</td><td>Teva Pharma B.V.                </td><td>Peripheral Vascular Diseases\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction\n",
       "Stroke                     </td></tr>\n",
       "\t<tr><th scope=row>1085</th><td>Clopidogrel Qualimed                                    </td><td>clopidogrel hydrochloride    </td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2009-09-22</td><td>2009</td><td>FALSE</td><td>France         </td><td>Qualimed                        </td><td>Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              </td></tr>\n",
       "\t<tr><th scope=row>1096</th><td>Clopidogrel Teva Generics B.V.                          </td><td>clopidogrel hydrochloride    </td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2010-10-27</td><td>2010</td><td>FALSE</td><td>The Netherlands</td><td>Teva Pharma B.V.                </td><td>Peripheral Vascular Diseases\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction\n",
       "Stroke                     </td></tr>\n",
       "\t<tr><th scope=row>1101</th><td>Clopidogrel ratiopharm                                  </td><td>clopidogrel                  </td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2009-09-22</td><td>2009</td><td>FALSE</td><td>Czech Republic </td><td>Archie Samuel s.r.o.            </td><td>Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              </td></tr>\n",
       "\t<tr><th scope=row>1135</th><td>Clopidogrel Acino Pharma GmbH                           </td><td>clopidogrel                  </td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2009-09-20</td><td>2009</td><td>FALSE</td><td>Germany        </td><td>Acino Pharma GmbH               </td><td>Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              </td></tr>\n",
       "\t<tr><th scope=row>1136</th><td>Clopidogrel Acino Pharma                                </td><td>clopidogrel                  </td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2009-09-20</td><td>2009</td><td>FALSE</td><td>Germany        </td><td>Acino Pharma GmbH               </td><td>Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              </td></tr>\n",
       "\t<tr><th scope=row>1137</th><td>Clopidogrel Hexal                                       </td><td>clopidogrel                  </td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2009-07-27</td><td>2009</td><td>FALSE</td><td>Germany        </td><td>Acino Pharma GmbH               </td><td>Peripheral Vascular Diseases\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction\n",
       "Stroke                     </td></tr>\n",
       "\t<tr><th scope=row>1149</th><td>Clopidogrel Sandoz                                      </td><td>clopidogrel                  </td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2009-09-20</td><td>2009</td><td>FALSE</td><td>Germany        </td><td>Acino Pharma GmbH               </td><td>Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              </td></tr>\n",
       "\t<tr><th scope=row>1159</th><td>Clopidogrel 1A Pharma                                   </td><td>clopidogrel                  </td><td>clopidogrel</td><td> TRUE</td><td>FALSE</td><td>2009-07-27</td><td>2009</td><td>FALSE</td><td>Germany        </td><td>Acino Pharma GmbH               </td><td>Peripheral Vascular Diseases                                                                             </td></tr>\n",
       "\t<tr><th scope=row>1168</th><td>Clopidogrel BMS                                         </td><td>clopidogrel hydrogen sulphate</td><td>clopidogrel</td><td>FALSE</td><td>FALSE</td><td>2008-07-15</td><td>2008</td><td>FALSE</td><td>United Kingdom </td><td>Bristol-Myers Squibb Pharma EEIG</td><td>Stroke\n",
       "Peripheral Vascular Diseases\n",
       "Myocardial Infarction\n",
       "Acute Coronary Syndrome                     </td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "A data.frame: 28 × 11\n",
       "\\begin{tabular}{r|lllllllllll}\n",
       "  & Name & substance\\_act & substance\\_inn & Generic & Orphan & Dates & Years & ex\\_circ & Countries & mah & mesh\\\\\n",
       "  & <chr> & <chr> & <chr> & <lgl{[},1{]}> & <lgl{[},1{]}> & <dttm> & <I<chr>> & <lgl{[},1{]}> & <chr> & <chr> & <chr>\\\\\n",
       "\\hline\n",
       "\t124 & Clopidogrel Apotex (previously Clopidogrel Mylan Pharma) & clopidogrel besilate          & clopidogrel &  TRUE & FALSE & 2009-10-15 & 2009 & FALSE & The Netherlands & Apotex Europe B.V.               & Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              \\\\\n",
       "\t390 & Clopidogrel HCS                                          & clopidogrel hydrochloride     & clopidogrel &  TRUE & FALSE & 2010-10-27 & 2010 & FALSE & Belgium         & HCS bvba                         & Peripheral Vascular Diseases\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction\n",
       "Stroke                     \\\\\n",
       "\t517 & Grepid                                                   & clopidogrel besilate          & clopidogrel &  TRUE & FALSE & 2009-07-27 & 2009 & FALSE & Greece          & Pharmathen S.A.                  & Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              \\\\\n",
       "\t543 & Clopidogrel Zentiva (previously Clopidogrel Winthrop)    & clopidogrel                   & clopidogrel & FALSE & FALSE & 2008-07-15 & 2008 & FALSE & Czech Republic  & Zentiva k.s.                     & Stroke\n",
       "Peripheral Vascular Diseases\n",
       "Myocardial Infarction\n",
       "Acute Coronary Syndrome                     \\\\\n",
       "\t580 & Clopidogrel Mylan                                        & clopidogrel hydrochloride     & clopidogrel &  TRUE & FALSE & 2009-09-20 & 2009 & FALSE & France          & Mylan S.A.S.                     & Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              \\\\\n",
       "\t582 & Clopidogrel Krka                                         & clopidogrel hydrochloride     & clopidogrel &  TRUE & FALSE & 2009-09-22 & 2009 & FALSE & Slovenia        & Krka, d.d., Novo mesto           & Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              \\\\\n",
       "\t585 & Zyllt                                                    & clopidogrel hydrogen sulphate & clopidogrel &  TRUE & FALSE & 2009-09-28 & 2009 & FALSE & Slovenia        & Krka, d.d., Novo mesto           & Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction                     \\\\\n",
       "\t589 & Clopidogrel TAD                                          & clopidogrel hydrochloride     & clopidogrel &  TRUE & FALSE & 2009-09-22 & 2009 & FALSE & Germany         & Tad Pharma GmbH                  & Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              \\\\\n",
       "\t607 & Clopidogrel ratiopharm GmbH                              & clopidogrel                   & clopidogrel &  TRUE & FALSE & 2009-07-27 & 2009 & FALSE & Czech Republic  & Archie Samiel s.r.o.             & Peripheral Vascular Diseases\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction\n",
       "Stroke                     \\\\\n",
       "\t609 & Clopidogrel ratiopharm                                   & clopidogrel hydrogen sulphate & clopidogrel &  TRUE & FALSE & 2015-02-18 & 2015 & FALSE & The Netherlands & Teva B.V.                        & Myocardial Infarction\n",
       "Acute Coronary Syndrome\n",
       "Peripheral Vascular Diseases\n",
       "Stroke                     \\\\\n",
       "\t639 & Plavix                                                   & clopidogrel hydrogen sulfate  & clopidogrel & FALSE & FALSE & 1998-07-15 & 1998 & FALSE & France          & Sanofi Clir SNC                  & Stroke\n",
       "Peripheral Vascular Diseases\n",
       "Atrial Fibrillation\n",
       "Myocardial Infarction\n",
       "Acute Coronary Syndrome\\\\\n",
       "\t743 & Iscover                                                  & clopidogrel                   & clopidogrel & FALSE & FALSE & 1998-07-14 & 1998 & FALSE & France          & Sanofi-Aventis Groupe            & Stroke\n",
       "Peripheral Vascular Diseases\n",
       "Atrial Fibrillation\n",
       "Myocardial Infarction\n",
       "Acute Coronary Syndrome\\\\\n",
       "\t793 & Clopidogrel Teva (hydrogen sulphate)                     & clopidogrel hydrogen sulphate & clopidogrel &  TRUE & FALSE & 2009-07-27 & 2009 & FALSE & The Netherlands & Teva Pharma B.V.                 & Acute Coronary Syndrome\n",
       "Peripheral Vascular Diseases\n",
       "Myocardial Infarction\n",
       "Stroke                     \\\\\n",
       "\t815 & Clopidogrel Acino                                        & clopidogrel                   & clopidogrel &  TRUE & FALSE & 2009-07-27 & 2009 & FALSE & Germany         & Acino AG                         & Peripheral Vascular Diseases\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction\n",
       "Stroke                     \\\\\n",
       "\t855 & Clopidogrel Teva Pharma (previously Clopidogrel HCS)     & clopidogrel hydrochloride     & clopidogrel &  TRUE & FALSE & 2009-09-20 & 2009 & FALSE & The Netherlands & Teva B.V.                        & Myocardial Infarction\n",
       "Peripheral Vascular Diseases\n",
       "Stroke                                              \\\\\n",
       "\t906 & Clopidogrel BGR (previously Zylagren)                    & clopidogrel hydrogen sulphate & clopidogrel &  TRUE & FALSE & 2009-09-20 & 2009 & FALSE & France          & Biogaran                         & Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              \\\\\n",
       "\t915 & Clopidogrel Krka d.d. (previously Zopya)                 & clopidogrel hydrochloride     & clopidogrel &  TRUE & FALSE & 2009-09-20 & 2009 & FALSE &                 &                                  &                                                                                                          \\\\\n",
       "\t1067 & Clopidogrel DURA                                         & clopidogrel hydrochloride     & clopidogrel &  TRUE & FALSE & 2009-07-20 & 2009 & FALSE & Germany         & Mylan dura GmbH                  & Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              \\\\\n",
       "\t1076 & Clopidogrel Teva Pharma B.V.                             & clopidogrel hydrobromide      & clopidogrel &  TRUE & FALSE & 2011-06-15 & 2011 & FALSE & The Netherlands & Teva Pharma B.V.                 & Peripheral Vascular Diseases\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction\n",
       "Stroke                     \\\\\n",
       "\t1085 & Clopidogrel Qualimed                                     & clopidogrel hydrochloride     & clopidogrel &  TRUE & FALSE & 2009-09-22 & 2009 & FALSE & France          & Qualimed                         & Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              \\\\\n",
       "\t1096 & Clopidogrel Teva Generics B.V.                           & clopidogrel hydrochloride     & clopidogrel &  TRUE & FALSE & 2010-10-27 & 2010 & FALSE & The Netherlands & Teva Pharma B.V.                 & Peripheral Vascular Diseases\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction\n",
       "Stroke                     \\\\\n",
       "\t1101 & Clopidogrel ratiopharm                                   & clopidogrel                   & clopidogrel &  TRUE & FALSE & 2009-09-22 & 2009 & FALSE & Czech Republic  & Archie Samuel s.r.o.             & Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              \\\\\n",
       "\t1135 & Clopidogrel Acino Pharma GmbH                            & clopidogrel                   & clopidogrel &  TRUE & FALSE & 2009-09-20 & 2009 & FALSE & Germany         & Acino Pharma GmbH                & Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              \\\\\n",
       "\t1136 & Clopidogrel Acino Pharma                                 & clopidogrel                   & clopidogrel &  TRUE & FALSE & 2009-09-20 & 2009 & FALSE & Germany         & Acino Pharma GmbH                & Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              \\\\\n",
       "\t1137 & Clopidogrel Hexal                                        & clopidogrel                   & clopidogrel &  TRUE & FALSE & 2009-07-27 & 2009 & FALSE & Germany         & Acino Pharma GmbH                & Peripheral Vascular Diseases\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction\n",
       "Stroke                     \\\\\n",
       "\t1149 & Clopidogrel Sandoz                                       & clopidogrel                   & clopidogrel &  TRUE & FALSE & 2009-09-20 & 2009 & FALSE & Germany         & Acino Pharma GmbH                & Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                              \\\\\n",
       "\t1159 & Clopidogrel 1A Pharma                                    & clopidogrel                   & clopidogrel &  TRUE & FALSE & 2009-07-27 & 2009 & FALSE & Germany         & Acino Pharma GmbH                & Peripheral Vascular Diseases                                                                             \\\\\n",
       "\t1168 & Clopidogrel BMS                                          & clopidogrel hydrogen sulphate & clopidogrel & FALSE & FALSE & 2008-07-15 & 2008 & FALSE & United Kingdom  & Bristol-Myers Squibb Pharma EEIG & Stroke\n",
       "Peripheral Vascular Diseases\n",
       "Myocardial Infarction\n",
       "Acute Coronary Syndrome                     \\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "A data.frame: 28 × 11\n",
       "\n",
       "| <!--/--> | Name &lt;chr&gt; | substance_act &lt;chr&gt; | substance_inn &lt;chr&gt; | Generic &lt;lgl[,1]&gt; | Orphan &lt;lgl[,1]&gt; | Dates &lt;dttm&gt; | Years &lt;I&lt;chr&gt;&gt; | ex_circ &lt;lgl[,1]&gt; | Countries &lt;chr&gt; | mah &lt;chr&gt; | mesh &lt;chr&gt; |\n",
       "|---|---|---|---|---|---|---|---|---|---|---|---|\n",
       "| 124 | Clopidogrel Apotex (previously Clopidogrel Mylan Pharma) | clopidogrel besilate          | clopidogrel |  TRUE | FALSE | 2009-10-15 | 2009 | FALSE | The Netherlands | Apotex Europe B.V.               | Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                               |\n",
       "| 390 | Clopidogrel HCS                                          | clopidogrel hydrochloride     | clopidogrel |  TRUE | FALSE | 2010-10-27 | 2010 | FALSE | Belgium         | HCS bvba                         | Peripheral Vascular Diseases\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction\n",
       "Stroke                      |\n",
       "| 517 | Grepid                                                   | clopidogrel besilate          | clopidogrel |  TRUE | FALSE | 2009-07-27 | 2009 | FALSE | Greece          | Pharmathen S.A.                  | Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                               |\n",
       "| 543 | Clopidogrel Zentiva (previously Clopidogrel Winthrop)    | clopidogrel                   | clopidogrel | FALSE | FALSE | 2008-07-15 | 2008 | FALSE | Czech Republic  | Zentiva k.s.                     | Stroke\n",
       "Peripheral Vascular Diseases\n",
       "Myocardial Infarction\n",
       "Acute Coronary Syndrome                      |\n",
       "| 580 | Clopidogrel Mylan                                        | clopidogrel hydrochloride     | clopidogrel |  TRUE | FALSE | 2009-09-20 | 2009 | FALSE | France          | Mylan S.A.S.                     | Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                               |\n",
       "| 582 | Clopidogrel Krka                                         | clopidogrel hydrochloride     | clopidogrel |  TRUE | FALSE | 2009-09-22 | 2009 | FALSE | Slovenia        | Krka, d.d., Novo mesto           | Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                               |\n",
       "| 585 | Zyllt                                                    | clopidogrel hydrogen sulphate | clopidogrel |  TRUE | FALSE | 2009-09-28 | 2009 | FALSE | Slovenia        | Krka, d.d., Novo mesto           | Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction                      |\n",
       "| 589 | Clopidogrel TAD                                          | clopidogrel hydrochloride     | clopidogrel |  TRUE | FALSE | 2009-09-22 | 2009 | FALSE | Germany         | Tad Pharma GmbH                  | Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                               |\n",
       "| 607 | Clopidogrel ratiopharm GmbH                              | clopidogrel                   | clopidogrel |  TRUE | FALSE | 2009-07-27 | 2009 | FALSE | Czech Republic  | Archie Samiel s.r.o.             | Peripheral Vascular Diseases\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction\n",
       "Stroke                      |\n",
       "| 609 | Clopidogrel ratiopharm                                   | clopidogrel hydrogen sulphate | clopidogrel |  TRUE | FALSE | 2015-02-18 | 2015 | FALSE | The Netherlands | Teva B.V.                        | Myocardial Infarction\n",
       "Acute Coronary Syndrome\n",
       "Peripheral Vascular Diseases\n",
       "Stroke                      |\n",
       "| 639 | Plavix                                                   | clopidogrel hydrogen sulfate  | clopidogrel | FALSE | FALSE | 1998-07-15 | 1998 | FALSE | France          | Sanofi Clir SNC                  | Stroke\n",
       "Peripheral Vascular Diseases\n",
       "Atrial Fibrillation\n",
       "Myocardial Infarction\n",
       "Acute Coronary Syndrome |\n",
       "| 743 | Iscover                                                  | clopidogrel                   | clopidogrel | FALSE | FALSE | 1998-07-14 | 1998 | FALSE | France          | Sanofi-Aventis Groupe            | Stroke\n",
       "Peripheral Vascular Diseases\n",
       "Atrial Fibrillation\n",
       "Myocardial Infarction\n",
       "Acute Coronary Syndrome |\n",
       "| 793 | Clopidogrel Teva (hydrogen sulphate)                     | clopidogrel hydrogen sulphate | clopidogrel |  TRUE | FALSE | 2009-07-27 | 2009 | FALSE | The Netherlands | Teva Pharma B.V.                 | Acute Coronary Syndrome\n",
       "Peripheral Vascular Diseases\n",
       "Myocardial Infarction\n",
       "Stroke                      |\n",
       "| 815 | Clopidogrel Acino                                        | clopidogrel                   | clopidogrel |  TRUE | FALSE | 2009-07-27 | 2009 | FALSE | Germany         | Acino AG                         | Peripheral Vascular Diseases\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction\n",
       "Stroke                      |\n",
       "| 855 | Clopidogrel Teva Pharma (previously Clopidogrel HCS)     | clopidogrel hydrochloride     | clopidogrel |  TRUE | FALSE | 2009-09-20 | 2009 | FALSE | The Netherlands | Teva B.V.                        | Myocardial Infarction\n",
       "Peripheral Vascular Diseases\n",
       "Stroke                                               |\n",
       "| 906 | Clopidogrel BGR (previously Zylagren)                    | clopidogrel hydrogen sulphate | clopidogrel |  TRUE | FALSE | 2009-09-20 | 2009 | FALSE | France          | Biogaran                         | Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                               |\n",
       "| 915 | Clopidogrel Krka d.d. (previously Zopya)                 | clopidogrel hydrochloride     | clopidogrel |  TRUE | FALSE | 2009-09-20 | 2009 | FALSE | <!----> | <!----> | <!----> |\n",
       "| 1067 | Clopidogrel DURA                                         | clopidogrel hydrochloride     | clopidogrel |  TRUE | FALSE | 2009-07-20 | 2009 | FALSE | Germany         | Mylan dura GmbH                  | Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                               |\n",
       "| 1076 | Clopidogrel Teva Pharma B.V.                             | clopidogrel hydrobromide      | clopidogrel |  TRUE | FALSE | 2011-06-15 | 2011 | FALSE | The Netherlands | Teva Pharma B.V.                 | Peripheral Vascular Diseases\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction\n",
       "Stroke                      |\n",
       "| 1085 | Clopidogrel Qualimed                                     | clopidogrel hydrochloride     | clopidogrel |  TRUE | FALSE | 2009-09-22 | 2009 | FALSE | France          | Qualimed                         | Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                               |\n",
       "| 1096 | Clopidogrel Teva Generics B.V.                           | clopidogrel hydrochloride     | clopidogrel |  TRUE | FALSE | 2010-10-27 | 2010 | FALSE | The Netherlands | Teva Pharma B.V.                 | Peripheral Vascular Diseases\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction\n",
       "Stroke                      |\n",
       "| 1101 | Clopidogrel ratiopharm                                   | clopidogrel                   | clopidogrel |  TRUE | FALSE | 2009-09-22 | 2009 | FALSE | Czech Republic  | Archie Samuel s.r.o.             | Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                               |\n",
       "| 1135 | Clopidogrel Acino Pharma GmbH                            | clopidogrel                   | clopidogrel |  TRUE | FALSE | 2009-09-20 | 2009 | FALSE | Germany         | Acino Pharma GmbH                | Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                               |\n",
       "| 1136 | Clopidogrel Acino Pharma                                 | clopidogrel                   | clopidogrel |  TRUE | FALSE | 2009-09-20 | 2009 | FALSE | Germany         | Acino Pharma GmbH                | Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                               |\n",
       "| 1137 | Clopidogrel Hexal                                        | clopidogrel                   | clopidogrel |  TRUE | FALSE | 2009-07-27 | 2009 | FALSE | Germany         | Acino Pharma GmbH                | Peripheral Vascular Diseases\n",
       "Acute Coronary Syndrome\n",
       "Myocardial Infarction\n",
       "Stroke                      |\n",
       "| 1149 | Clopidogrel Sandoz                                       | clopidogrel                   | clopidogrel |  TRUE | FALSE | 2009-09-20 | 2009 | FALSE | Germany         | Acino Pharma GmbH                | Peripheral Vascular Diseases\n",
       "Stroke\n",
       "Myocardial Infarction                                               |\n",
       "| 1159 | Clopidogrel 1A Pharma                                    | clopidogrel                   | clopidogrel |  TRUE | FALSE | 2009-07-27 | 2009 | FALSE | Germany         | Acino Pharma GmbH                | Peripheral Vascular Diseases                                                                              |\n",
       "| 1168 | Clopidogrel BMS                                          | clopidogrel hydrogen sulphate | clopidogrel | FALSE | FALSE | 2008-07-15 | 2008 | FALSE | United Kingdom  | Bristol-Myers Squibb Pharma EEIG | Stroke\n",
       "Peripheral Vascular Diseases\n",
       "Myocardial Infarction\n",
       "Acute Coronary Syndrome                      |\n",
       "\n"
      ],
      "text/plain": [
       "     Name                                                    \n",
       "124  Clopidogrel Apotex (previously Clopidogrel Mylan Pharma)\n",
       "390  Clopidogrel HCS                                         \n",
       "517  Grepid                                                  \n",
       "543  Clopidogrel Zentiva (previously Clopidogrel Winthrop)   \n",
       "580  Clopidogrel Mylan                                       \n",
       "582  Clopidogrel Krka                                        \n",
       "585  Zyllt                                                   \n",
       "589  Clopidogrel TAD                                         \n",
       "607  Clopidogrel ratiopharm GmbH                             \n",
       "609  Clopidogrel ratiopharm                                  \n",
       "639  Plavix                                                  \n",
       "743  Iscover                                                 \n",
       "793  Clopidogrel Teva (hydrogen sulphate)                    \n",
       "815  Clopidogrel Acino                                       \n",
       "855  Clopidogrel Teva Pharma (previously Clopidogrel HCS)    \n",
       "906  Clopidogrel BGR (previously Zylagren)                   \n",
       "915  Clopidogrel Krka d.d. (previously Zopya)                \n",
       "1067 Clopidogrel DURA                                        \n",
       "1076 Clopidogrel Teva Pharma B.V.                            \n",
       "1085 Clopidogrel Qualimed                                    \n",
       "1096 Clopidogrel Teva Generics B.V.                          \n",
       "1101 Clopidogrel ratiopharm                                  \n",
       "1135 Clopidogrel Acino Pharma GmbH                           \n",
       "1136 Clopidogrel Acino Pharma                                \n",
       "1137 Clopidogrel Hexal                                       \n",
       "1149 Clopidogrel Sandoz                                      \n",
       "1159 Clopidogrel 1A Pharma                                   \n",
       "1168 Clopidogrel BMS                                         \n",
       "     substance_act                 substance_inn Generic Orphan Dates     \n",
       "124  clopidogrel besilate          clopidogrel    TRUE   FALSE  2009-10-15\n",
       "390  clopidogrel hydrochloride     clopidogrel    TRUE   FALSE  2010-10-27\n",
       "517  clopidogrel besilate          clopidogrel    TRUE   FALSE  2009-07-27\n",
       "543  clopidogrel                   clopidogrel   FALSE   FALSE  2008-07-15\n",
       "580  clopidogrel hydrochloride     clopidogrel    TRUE   FALSE  2009-09-20\n",
       "582  clopidogrel hydrochloride     clopidogrel    TRUE   FALSE  2009-09-22\n",
       "585  clopidogrel hydrogen sulphate clopidogrel    TRUE   FALSE  2009-09-28\n",
       "589  clopidogrel hydrochloride     clopidogrel    TRUE   FALSE  2009-09-22\n",
       "607  clopidogrel                   clopidogrel    TRUE   FALSE  2009-07-27\n",
       "609  clopidogrel hydrogen sulphate clopidogrel    TRUE   FALSE  2015-02-18\n",
       "639  clopidogrel hydrogen sulfate  clopidogrel   FALSE   FALSE  1998-07-15\n",
       "743  clopidogrel                   clopidogrel   FALSE   FALSE  1998-07-14\n",
       "793  clopidogrel hydrogen sulphate clopidogrel    TRUE   FALSE  2009-07-27\n",
       "815  clopidogrel                   clopidogrel    TRUE   FALSE  2009-07-27\n",
       "855  clopidogrel hydrochloride     clopidogrel    TRUE   FALSE  2009-09-20\n",
       "906  clopidogrel hydrogen sulphate clopidogrel    TRUE   FALSE  2009-09-20\n",
       "915  clopidogrel hydrochloride     clopidogrel    TRUE   FALSE  2009-09-20\n",
       "1067 clopidogrel hydrochloride     clopidogrel    TRUE   FALSE  2009-07-20\n",
       "1076 clopidogrel hydrobromide      clopidogrel    TRUE   FALSE  2011-06-15\n",
       "1085 clopidogrel hydrochloride     clopidogrel    TRUE   FALSE  2009-09-22\n",
       "1096 clopidogrel hydrochloride     clopidogrel    TRUE   FALSE  2010-10-27\n",
       "1101 clopidogrel                   clopidogrel    TRUE   FALSE  2009-09-22\n",
       "1135 clopidogrel                   clopidogrel    TRUE   FALSE  2009-09-20\n",
       "1136 clopidogrel                   clopidogrel    TRUE   FALSE  2009-09-20\n",
       "1137 clopidogrel                   clopidogrel    TRUE   FALSE  2009-07-27\n",
       "1149 clopidogrel                   clopidogrel    TRUE   FALSE  2009-09-20\n",
       "1159 clopidogrel                   clopidogrel    TRUE   FALSE  2009-07-27\n",
       "1168 clopidogrel hydrogen sulphate clopidogrel   FALSE   FALSE  2008-07-15\n",
       "     Years ex_circ Countries       mah                             \n",
       "124  2009  FALSE   The Netherlands Apotex Europe B.V.              \n",
       "390  2010  FALSE   Belgium         HCS bvba                        \n",
       "517  2009  FALSE   Greece          Pharmathen S.A.                 \n",
       "543  2008  FALSE   Czech Republic  Zentiva k.s.                    \n",
       "580  2009  FALSE   France          Mylan S.A.S.                    \n",
       "582  2009  FALSE   Slovenia        Krka, d.d., Novo mesto          \n",
       "585  2009  FALSE   Slovenia        Krka, d.d., Novo mesto          \n",
       "589  2009  FALSE   Germany         Tad Pharma GmbH                 \n",
       "607  2009  FALSE   Czech Republic  Archie Samiel s.r.o.            \n",
       "609  2015  FALSE   The Netherlands Teva B.V.                       \n",
       "639  1998  FALSE   France          Sanofi Clir SNC                 \n",
       "743  1998  FALSE   France          Sanofi-Aventis Groupe           \n",
       "793  2009  FALSE   The Netherlands Teva Pharma B.V.                \n",
       "815  2009  FALSE   Germany         Acino AG                        \n",
       "855  2009  FALSE   The Netherlands Teva B.V.                       \n",
       "906  2009  FALSE   France          Biogaran                        \n",
       "915  2009  FALSE                                                   \n",
       "1067 2009  FALSE   Germany         Mylan dura GmbH                 \n",
       "1076 2011  FALSE   The Netherlands Teva Pharma B.V.                \n",
       "1085 2009  FALSE   France          Qualimed                        \n",
       "1096 2010  FALSE   The Netherlands Teva Pharma B.V.                \n",
       "1101 2009  FALSE   Czech Republic  Archie Samuel s.r.o.            \n",
       "1135 2009  FALSE   Germany         Acino Pharma GmbH               \n",
       "1136 2009  FALSE   Germany         Acino Pharma GmbH               \n",
       "1137 2009  FALSE   Germany         Acino Pharma GmbH               \n",
       "1149 2009  FALSE   Germany         Acino Pharma GmbH               \n",
       "1159 2009  FALSE   Germany         Acino Pharma GmbH               \n",
       "1168 2008  FALSE   United Kingdom  Bristol-Myers Squibb Pharma EEIG\n",
       "     mesh                                                                                                     \n",
       "124  Peripheral Vascular Diseases\\nStroke\\nMyocardial Infarction                                              \n",
       "390  Peripheral Vascular Diseases\\nAcute Coronary Syndrome\\nMyocardial Infarction\\nStroke                     \n",
       "517  Peripheral Vascular Diseases\\nStroke\\nMyocardial Infarction                                              \n",
       "543  Stroke\\nPeripheral Vascular Diseases\\nMyocardial Infarction\\nAcute Coronary Syndrome                     \n",
       "580  Peripheral Vascular Diseases\\nStroke\\nMyocardial Infarction                                              \n",
       "582  Peripheral Vascular Diseases\\nStroke\\nMyocardial Infarction                                              \n",
       "585  Peripheral Vascular Diseases\\nStroke\\nAcute Coronary Syndrome\\nMyocardial Infarction                     \n",
       "589  Peripheral Vascular Diseases\\nStroke\\nMyocardial Infarction                                              \n",
       "607  Peripheral Vascular Diseases\\nAcute Coronary Syndrome\\nMyocardial Infarction\\nStroke                     \n",
       "609  Myocardial Infarction\\nAcute Coronary Syndrome\\nPeripheral Vascular Diseases\\nStroke                     \n",
       "639  Stroke\\nPeripheral Vascular Diseases\\nAtrial Fibrillation\\nMyocardial Infarction\\nAcute Coronary Syndrome\n",
       "743  Stroke\\nPeripheral Vascular Diseases\\nAtrial Fibrillation\\nMyocardial Infarction\\nAcute Coronary Syndrome\n",
       "793  Acute Coronary Syndrome\\nPeripheral Vascular Diseases\\nMyocardial Infarction\\nStroke                     \n",
       "815  Peripheral Vascular Diseases\\nAcute Coronary Syndrome\\nMyocardial Infarction\\nStroke                     \n",
       "855  Myocardial Infarction\\nPeripheral Vascular Diseases\\nStroke                                              \n",
       "906  Peripheral Vascular Diseases\\nStroke\\nMyocardial Infarction                                              \n",
       "915                                                                                                           \n",
       "1067 Peripheral Vascular Diseases\\nStroke\\nMyocardial Infarction                                              \n",
       "1076 Peripheral Vascular Diseases\\nAcute Coronary Syndrome\\nMyocardial Infarction\\nStroke                     \n",
       "1085 Peripheral Vascular Diseases\\nStroke\\nMyocardial Infarction                                              \n",
       "1096 Peripheral Vascular Diseases\\nAcute Coronary Syndrome\\nMyocardial Infarction\\nStroke                     \n",
       "1101 Peripheral Vascular Diseases\\nStroke\\nMyocardial Infarction                                              \n",
       "1135 Peripheral Vascular Diseases\\nStroke\\nMyocardial Infarction                                              \n",
       "1136 Peripheral Vascular Diseases\\nStroke\\nMyocardial Infarction                                              \n",
       "1137 Peripheral Vascular Diseases\\nAcute Coronary Syndrome\\nMyocardial Infarction\\nStroke                     \n",
       "1149 Peripheral Vascular Diseases\\nStroke\\nMyocardial Infarction                                              \n",
       "1159 Peripheral Vascular Diseases                                                                             \n",
       "1168 Stroke\\nPeripheral Vascular Diseases\\nMyocardial Infarction\\nAcute Coronary Syndrome                     "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "# How much later were generics approved?\n",
    "df[df['substance_inn'] == 'clopidogrel',]"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Orphan drugs\n",
    "\n",
    "From the year 2000, orphan drug development is promoted by the EMA. Indeed, they only appear from the year 2001, after the definition of \"orphan designation\" by the EMA in 2000 ([see Regulation](https://www.ema.europa.eu/en/human-regulatory/overview/orphan-designation/legal-framework-orphan-designation)).\n",
    "\n",
    "In relation to the drugs approved last year 2018, the proportion of approved orphan drugs is at the highest levels compared to the past. This may indicate that the directives from the EMA are starting to show a clear effect in research and development of drugs that apparently may not be of direct economic interest. On the other hand, since orphan drugs target rare diseases, the high rate of approval may be confouded by an accelerated approval because potential benefits outperform risks."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 133,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    }
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "[1] \"12.66 % of the drugs registered are orphan.\"\n"
     ]
    },
    {
     "data": {
      "image/png": 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3dPTEysra0tLCzcuHGjMjX3rP79+0+YMKGqqio1NbWrPkePHiWE+Pv7y2/U1DdE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\nSUVORK5CYII=",
      "text/plain": [
       "Plot with title “EMA Orphan”"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "# visualize\n",
    "options(repr.plot.width=3, repr.plot.height=3)\n",
    "\n",
    "# Orphan vs non-orphan\n",
    "tmp = table(df$Orphan)\n",
    "barplot(tmp, main = 'EMA Orphan',col=c('brown','darkgreen'),names.arg = c('Not orphan','Orphan'))\n",
    "#legend('topright',legend = c('Not orphan','Orphan'),fill = c('brown','darkgreen'))\n",
    "\n",
    "print(paste(round(100*tmp[2]/sum(tmp),2),'% of the drugs registered are orphan.'))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 36,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    }
   },
   "outputs": [
    {
     "data": {
      "image/png": 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+/efMmZObm2tZQafTrVq1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",
      "text/plain": [
       "Plot with title “Evolution of Orphan Drugs”"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "# visualization options\n",
    "options(repr.plot.width=10, repr.plot.height=3)\n",
    "\n",
    "# Evolution of orphan drugs\n",
    "tmp = table(df$Orphan,df$Years)\n",
    "df.bar = barplot(tmp,col=c('brown','darkgreen'),las=2, main='Evolution of Orphan Drugs')\n",
    "lines(df.bar,(tmp[2,]/colSums(tmp))*100,lty=2,lwd=3)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Countries\n",
    "\n",
    "Below I analyzed which countries hold the Marketing Authorizations of approved drugs."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 37,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    }
   },
   "outputs": [
    {
     "data": {
      "image/png": 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pYeCE1ydnYWBKGsrMzKysrV1fX69etGHTIyMtzd3U2elAgAAAAAkFh0ZEpJSXF3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24nUyZmZmeIMmDMOuXbsmKCiopKT09u1b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\nD2tCOSzE3JLJAAAAAElFTkSuQmCC",
      "text/plain": [
       "Plot with title “Number of drugs approved”"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "# visualize\n",
    "options(repr.plot.width=10, repr.plot.height=4)\n",
    "\n",
    "# Orphan vs non-orphan\n",
    "tmp = table(df$Countries[df$Countries!='']) # unsuccessful applications will have an empty Country\n",
    "\n",
    "tmp = tmp[order(tmp, decreasing = T)]\n",
    "barplot(tmp, main = 'Number of drugs approved',las=2,col='lightblue')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 38,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    }
   },
   "outputs": [
    {
     "data": {
      "image/png": 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Hr0KC3VyhTmDSRvwisX9eoFAGBgAO7ugi3x8RAdLf+gUI1g3kBylshOpMpUQwUA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\njb7l4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eFaM6d+5cYmKil5dXWFjYtm3b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\nERERkeT8H3cJnKmxhcnIAAAAAElFTkSuQmCC",
      "text/plain": [
       "Plot with title “Approved Drugs in Italy”"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "# visualize\n",
    "n_countries = 9\n",
    "options(repr.plot.width=9, repr.plot.height=n_countries*0.75)\n",
    "\n",
    "# Evolution\n",
    "tmp = table(df$Countries,df$Years)\n",
    "tmp = tmp[order(rowSums(tmp),decreasing=T),]\n",
    "\n",
    "par(mfrow=c(n_countries%/%3,3))\n",
    "for (i in 1:length(tmp[1:n_countries])){\n",
    "    plot(as.numeric(colnames(tmp)),tmp[i,],main=paste('Approved Drugs in',rownames(tmp)[i]),type='l',bty='n',xlab='Year',ylab='n_approved',col=i,lty=2,lwd=3,ylim=c(0,25))\n",
    "}"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "The general trends for countries with more than 100 approved drugs are show trends linearly positive indicating that either countries \"improve\" in how to get drugs approved or that companies strategically choose countries closer to the EMA headquarters (London, UK) to facilitate administrative interactions. In the case of Germany, the peak corresponds to the approval of many generics of the *clopidogrel*."
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Companies holding Marketing Authorisations\n",
    "\n",
    "In this section I dissect EMA public data to understand the main trends among european companies to approve their products."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 39,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    }
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "[1] \"There are a total of 448 different companies registered as MAH.\"\n",
      "[1] \"These are the top 10:\"\n",
      "\n",
      "             Novartis Europharm Limited                               Teva B.V. \n",
      "                                     54                                      28 \n",
      "               Eli Lilly Nederland B.V.                   Pfizer Europe MA EEIG \n",
      "                                     25                                      25 \n",
      "               Merck Sharp & Dohme B.V.                        Novo Nordisk A/S \n",
      "                                     22                                      22 \n",
      "                         AstraZeneca AB Boehringer Ingelheim International GmbH \n",
      "                                     21                                      21 \n",
      "                Roche Registration GmbH                          Pfizer Limited \n",
      "                                     21                                      18 \n"
     ]
    }
   ],
   "source": [
    "# MAH top ten\n",
    "tmp = table(df$mah[df$mah!=''])# unsuccessful applications will have an empty mah\n",
    "order_freq = order(tmp, decreasing = T)\n",
    "tmp = tmp[order_freq]\n",
    "\n",
    "print(paste('There are a total of',length(tmp),'different companies registered as MAH.'))\n",
    "print('These are the top 10:')\n",
    "print(tmp[1:10])\n",
    "\n",
    "mah_freq = tmp"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Disease interests of each company\n",
    "\n",
    "Pharmaceutical companies main revenues are based on the number on prescriptions. Then, a pharmaceutical company may opt to either develop a drug product with a broad range of indications (many patients) or the best drug(s) for a small number of indications. "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 102,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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AMrBJeE5/LvrSK1DqDSNFF//Mno6kXaI0vOrG8duUl7lYcSBzK8YK2RI6Aau6Vy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\nHBKMHBKMHBKMnP8HT0cSSQozWBAAAAAASUVORK5CYII=",
      "text/plain": [
       "plot without title"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "disint = list() # init disease interests\n",
    "for (tmp_mah in names(mah_freq)){\n",
    "    # subset\n",
    "    idx_names = df[df['mah'] == tmp_mah,1] # 1st column is the Names column\n",
    "    \n",
    "    # get mesh vocabulary for tmp_mah\n",
    "    disint[tmp_mah] = list(unique(unlist(list_mesh[idx_names])))\n",
    "}\n",
    "\n",
    "#print('Number of different indications for the top 10 most MAHs:')\n",
    "tmp = sapply(disint,length)\n",
    "#print(tmp[1:10])\n",
    "mah_disint = tmp\n",
    "\n",
    "tmp = tmp[order(tmp,decreasing=T)]\n",
    "#print('')\n",
    "#print('Top 10 companies with most different indications among their products:')\n",
    "#print(tmp[1:10])\n",
    "\n",
    "options(repr.plot.width=4, repr.plot.height=4)\n",
    "plot(as.vector(mah_freq),as.vector(mah_disint),pch=19,bty='n',xlab='Approved Drugs',ylab='MeSH variety')"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "The number of approved drugs and different indications correlates linearly; most of the companies chose to develop many drugs with few indications, which is more realistic."
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Company level of disease Specificity\n",
    "\n",
    "Computing the ratio of indications per product we summarize the two variables above into a variable that shows how specific are the products developed by each company in average.\n",
    "\n",
    "$$Spec_{company} = log_{10}(\\frac{n_{Disease Indications}}{n_{Approved Drugs}})$$"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 105,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    }
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "[1] \"Number of indications per product:\"\n",
      "\n",
      "             Novartis Europharm Limited                               Teva B.V. \n",
      "                             0.02348110                              0.12104369 \n",
      "               Eli Lilly Nederland B.V.                   Pfizer Europe MA EEIG \n",
      "                            -0.05551733                              0.17026172 \n",
      "               Merck Sharp & Dohme B.V.                        Novo Nordisk A/S \n",
      "                             0.14893901                             -0.38818017 \n",
      "                         AstraZeneca AB Boehringer Ingelheim International GmbH \n",
      "                            -0.32221929                             -0.02118930 \n",
      "                Roche Registration GmbH                          Pfizer Limited \n",
      "                             0.09275405                              0.14266750 \n",
      "[1] \"\"\n",
      "[1] \"Companies that develop products targeting a broad spectrum of indications (Top 10):\"\n",
      "\n",
      "                   Sanofi Pasteur            Instituto Grifols S.A. \n",
      "                         0.845098                          0.698970 \n",
      "                            Medac                 Therakind Limited \n",
      "                         0.698970                          0.698970 \n",
      "Samsung Bioepis UK Limited (SBUK)             Sanofi Pasteur Europe \n",
      "                         0.602060                          0.602060 \n",
      "                         Acino AG              Archie Samiel s.r.o. \n",
      "                         0.602060                          0.602060 \n",
      "             Archie Samuel s.r.o.      Aspen Pharma Trading Limited \n",
      "                         0.602060                          0.602060 \n",
      "[1] \"\"\n",
      "[1] \"Companies that develop drugs mostly for the same indications (Top 10):\"\n",
      "\n",
      "               Actavis Group hf          KRKA, d.d., Novo mesto \n",
      "                           -Inf                      -0.6989700 \n",
      "                    Takeda GmbH         Novartis Europharm Ltd. \n",
      "                     -0.6989700                      -0.6532125 \n",
      "         SmithKline Beecham Plc     ViiV Healthcare UK Limited  \n",
      "                     -0.6020600                      -0.6020600 \n",
      "sanofi-aventis Deutschland GmbH                   UCB Pharma SA \n",
      "                     -0.4771213                      -0.4771213 \n",
      "     ViiV Healthcare UK Limited                Novo Nordisk A/S \n",
      "                     -0.4771213                      -0.3881802 \n"
     ]
    }
   ],
   "source": [
    "tmp = log10(mah_disint / mah_freq)\n",
    "mah_ratio = tmp\n",
    "\n",
    "print('Number of indications per product:')\n",
    "print(tmp[1:10])\n",
    "print('')\n",
    "\n",
    "print('Companies that develop products targeting a broad spectrum of indications (Top 10):')\n",
    "tmp=tmp[order(tmp,decreasing=T)]\n",
    "print(tmp[1:10])\n",
    "print('')\n",
    "\n",
    "print('Companies that develop drugs mostly for the same indications (Top 10):')\n",
    "tmp=tmp[order(tmp,decreasing=F)]\n",
    "print(tmp[1:10])"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Which approach was more successful at long term?\n",
    "\n",
    "I computed a *score* that approximates the *development rate* of a company based on the spread (std) of the data and the total number of approved drugs.\n",
    "\n",
    "$$ Score_{company} = Std \\cdot n_{Approved Drugs} $$"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 116,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    }
   },
   "outputs": [],
   "source": [
    "df_mah = data.frame(as.vector(mah_freq),as.vector(mah_disint),as.vector(mah_ratio))\n",
    "colnames(df_mah) = c('freq','disint','spec')\n",
    "rownames(df_mah) = names(mah_freq)\n",
    "\n",
    "# compute the spread of the points along time\n",
    "tmp = table(df$mah[df$mah!=''],df$Years[df$mah!=''])\n",
    "tmp = tmp[order_freq,]\n",
    "\n",
    "df_mah['spread'] = apply(tmp,1,function(row){\n",
    "    idx_first_mah = which.min(row>0)\n",
    "    subst = row[idx_first_mah:length(row)]\n",
    "    return(sd(subst))\n",
    "})\n",
    "df_mah['score'] = df_mah$spread*df_mah$freq\n",
    "\n",
    "df_mah = df_mah[order(df_mah['score'],decreasing=T),]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 132,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    }
   },
   "outputs": [
    {
     "data": {
      "image/png": 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BZwJ56KKwjLKhAWcCeeiisIyyoQFnAnnoorCMsqEBZwJ56KKwjLKhAWcCeeiisI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\n1wBhAQBcA4QFAHANEBYAwDVAWAAA1/D/28oDq4vd7lAAAAAASUVORK5CYII=",
      "text/plain": [
       "Plot with title “Specificity ditribution”"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "# visualize options\n",
    "options(repr.plot.width=10, repr.plot.height=4)\n",
    "\n",
    "# Specificity vs score\n",
    "par(mfrow=c(1,2))\n",
    "plot(df_mah$spec,df_mah$score,pch=19,bty='n',xlab='Specificity',ylab='Score',main='Optimal conditions to\\ncomplete drug development')\n",
    "text(df_mah$spec[1],df_mah$score[1]-10,rownames(df_mah)[1],cex=.75)\n",
    "text(df_mah$spec[2],df_mah$score[2]+10,rownames(df_mah)[2],cex=.75)\n",
    "text(df_mah$spec[4]-0.05,df_mah$score[4]+6,rownames(df_mah)[4],cex=.75)\n",
    "\n",
    "hist(df_mah$spec,main='Specificity ditribution',breaks=12,col='grey',xlab='Specificity',xlim=c(-1,1))"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Apparently, there is a tradeoff in drug development between constant development of many and very specific products and development of few products targeting many indications. There are no cases of companies constantly developing products that cover a broad range of indications. Developing many specific products ensures a constant rate of MA approvals and revenue (e.g. Novartis Europharm Limited and Teva B.V.). Nevertheless, we see certain companies like Novo Nordisk A/S that developed many products covering a the same indications. This strategy may respond to the rationale of modifying the same drug to re-approve it with the need of less clinical trials, with the high risk that this implies."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 125,
   "metadata": {
    "jupyter": {
     "source_hidden": true
    }
   },
   "outputs": [
    {
     "data": {
      "image/png": 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Qzvt99+CwgI8Pf3X7VqldixAAAAAIBZQqEChvfRRx+VlpYqFIr333+f53mxwwEA\nAAAA84NCBQwvJyeHNUpKSiQSibjBAAAAAIA5QqEChldQUMAaYWFhDg4O4gYDAAAAAOYIhQoY\nGM/zQqHi5+cnbjAAAAAAYKZQqICBFRUVSaVS1vb19RU3GAAAAAAwUyhUwMCE7hQi8vb2FjES\nAAAAADBfKFTAwPLz84U2ChUAAAAA0A0KFTAw9KgAAAAAgP5QqICBKfeo+Pj4iBgJAAAAAJgv\nFCpgYOhRAQAAAAD9oVABA1MuVNCjAgAAAAC6QaECBobJ9AAAAACgPxQqYGDoUQEAAAAA/aFQ\nAQMTelQ4jvP09BQ3GAAAAAAwUyhUwMAePHjAGs7Ozps2bVqyZMmdO3fEDQkAAAAAzI6N2AGA\npQkICLhw4QIRlZSUTJ06lYh+/PHH5ORkseMCAAAAAHOCHhUwsHXr1g0ePHjgwIEdOnRgWy5d\nupSTkyNuVAAAAABgXkQoVJKTkzdt2nTjxg0i+u6775577rlPPvmE53njRwL1ISIi4pdffjl0\n6FDv3r2FjampqSKGBBYAeQMAtIW8AWDujD30a+vWra+88kpYWNidO3fmz5+/Y8eOMWPGfPHF\nFxKJZO7cuUYOBupVaGio0E5JSenevbuIwYBZQ94AAG0hbwBYAGMXKkuXLv3mm28mTJiwc+fO\nMWPGHD9+PCYmpnPnztOmTVOfOBQKRVFRUc3tUqm03oIFvYSFhQntlJQUESMBc4e8AQDaQt4A\nsADGLlSysrL69OlDRGxcUHR0NBG1bt26zjkMS5cuXbZsmcq78FO9aVIuVDD0C/SBvAEA2kLe\nALAAxi5U2rZt+/HHH8+dO/eTTz7hOC4xMfGFF144fPhwixYt1D9wzpw5w4YNq7n93XffrfOx\nIIqQkBArKyuFQkHoUQH9IG8AgLaQNwAsgLELlXXr1g0ZMmTdunXh4eFHjx4dO3bsl19+eerU\nqR9++EH9A11cXIRVpJR5eHjY2GCRZVPk4OAQGBiYlZVFKFRAP8gbAKAt5A0AC2Dsj1yHDh0y\nMzMzMzODg4OtrKySkpJ+/fXXDz74oGPHjkaOBIwgLCyMFSrZ2dkVFRUODg5iRwRmCXkDALSF\nvAFgAUT4bcDGxkZYDyoqKioqKsr4MYBxhIaG/vHHH0TE83xaWho6zUFnyBsAoC3kDQBzhws+\nQj2qtkKxiJEAAAAAgHlBoQL1CCsUAwAAAIBuUKhAPcIKxQAAAACgGxQqYEj790JrE1gAACAA\nSURBVO8PDQ1t27bt5cuXiahZs2bCXbdv3xYvLgAAAAAwMyhUwJBef/31tLS0CxcuxMXFEVGj\nRo2cnZ3ZXRj6BQAAAACaQ6ECBlNRUSFc8be4uJiIOI4T5tNj6BcAAAAAaA6FChhMQUGB0Pbx\n8WENYUliKyv8sQEAAACApnDuCAaTn58vtL29vVnjvffeCwoKcnR0XLlypUhxAQAAAID5EeGC\nj2CpVPaotGnTJiMjQy6XW1tbixQXAAAAAJgf9KiAweTl5QltoVBhUKUAAAAAgFZQqIDBKPeo\nCEO/AAAAAAB0gEIFDEZ5jkq1HhUAAAAAAK2gUAGDQY8KAAAAABgKChUwGJWT6QEAAAAAdIBC\nBQxG5fLEAAAAAAA6QKECBiP0qDg4ODg7O4sbDAAAAACYNRQqYDBCoYLuFAAAAADQEwoVMBhh\n6BcmqAAAAACAnlCogGFUVlaWlJSwNnpUAAAAAEBPKFTAMB48eMDzPGvXLFRycnJGjBjRp0+f\nEydOGD00AAAAADA/NmIHABbC09PTw8OjsLCQiFq3bl3t3kWLFu3Zs4eIXnzxxYyMDBHiAwAA\nAACzgkIFDMPOzu7nn3/+6KOPmjdvPnv27Gr35uXlsUZmZmZeXp6vr6/RAwQAAAAAc/JEoTJ/\n/vza9gsICJg5c2b9xwNmrEePHj169FB5V0hIiNBOTU1FoWJJkDcAQFvIGwCgiSfmqFQ8kpub\nu3LlylOnTt2/f//s2bMff/yxtbW1WCGCBQgNDRXaKSkpIkYCBoe8AQDaQt4AAE080aPy3//+\nlzVGjx69YcOGadOmsZsbN2789ddfp0+fbuzowFKEhYUJbRQqFgZ5AwC0hbwBAJpQverXb7/9\nNmrUKOHm888/f/jwYWOFBBZIuVBJTU0VMRKoP8gbAKAt5A0AUEN1odK4ceNDhw4JN3/99dcm\nTZoYKySwQGFhYRzHsTZ6VCwV8gYAaAt5AwDUUL3qV3x8/Isvvvjzzz9HRETcuHFj//7927dv\nN3JkYEmcnJz8/Pxyc3MJhYrlQt4AAG0hbwCAGqp7VIYPH3727NnQ0NCMjIyIiIh//vnn+eef\nN3JkYGGE0V+ZmZmVlZXiBgP1AXkDALSFvAEAatR6Zfr09PTS0lKe52fOnHnlyhVjxgQWSShU\n5HI5rvloqZA3AEBbyBsAUBvVhcrXX389fvx4Ly+vI0eOWFlZzZgx49NPPzVyZGBhsPCXxUPe\nAABtIW8AgBqqC5Xly5dv37596dKlROTr67tnzx5hJUEA3eBSKhYPeQMAtIW8AQBqqC5U8vPz\n27ZtK9xs0aIFmwZtEPv27SsoKOB5fuPGjc8///yLL764b98+Qx0cRCSXy9Xc26xZM6GNQsUi\nIW8AgLaQNwBADdWFSpcuXb7++mvh5vbt29u1a2eQ51u5cuWkSZNkMtn777//3nvvtW7dOiws\nbPLkycpPB+botddes7Oz69at24MHD1TugKFfFg95AwC0hbwBAGpwPM/X3Hrjxo0BAwZ4enpe\nu3atbdu2KSkpCQkJ7du31//5AgICdu/eHRMT06RJk927d3ft2pWIjh079tprr12/fl3NA2/e\nvHn06NGa27/44os2bdp8++23+scGOjt//rzw57Fu3boZM2bU3EehUDg7O1dUVBBRu3bt/vnn\nH6OGCPUPeQMAtIW8AQBqqL6OSvPmza9fv56QkJCSkhIQEDB48GAPDw+DPJ9cLg8JCSEiqVQq\njAWKjo6us6v38OHDa9asqbk9NzfXy8vLILGBzpRX8ZJIJCr3sbKyCgkJuXbtWrX9wWIgbwCA\ntpA3AEAN1T0qZ86c6dy5c30838svv2xra7t+/fr33nvP1dV12bJlCoVi/vz5Fy5cSEhI0OGA\nI0aMaNKkydq1aw0eKmhu48aNkydPFtoTJ05Uudu4ceO2bNlCRC1btrx06ZLx4gOjQN4AAG0h\nbwCAGqp7VPr27RscHDxx4sSXX365UaNGBny+zz777MUXXwwICAgJCUlOTt64caNUKvX39z9w\n4IABnwWMrKCgQGj7+PjUthv7jaqwsDA+Pt4YYYFxIW8AgLaQNwBADdWFyr17937++eft27cv\nWbKkb9++EydOHDJkiK2trf7P5+rqeuDAgZs3byYnJ+fm5np4eERERHTs2FH/I4OI8vPzhbaa\nQqVRo0Y//PCDUSICESBvAIC2kDcAQA3VQ78ERUVFe/fuXbFiRUFBwb1794wWlubQFWsKJk+e\nvHHjRta+fv168+bNxY0HxIW8AQDaQt4AgJpU96gwly5d2r17948//njnzp3hw4cbLSYwOxoO\n/YKGAHkDALSFvAEAKqm+jsrChQsjIyM7d+585cqVZcuW3bt3b9OmTcYNDMyJMPTL2traUAu2\ngNlB3gAAbSFvAIAaqntULl68GBcX99xzz7m4uBg5IDBHQo+Kp6enlZXq6hcsHvIGAGgLeQMA\n1FBdqPz8889nz5597733MjIymjRp8n//939dunQxcmRgRoQeFYz7asiQNwBAW8gbAKCG6h+/\nd+zY0adPn4qKiu7du8tksv79++/cudPIkYG5UCgUDx48YG1vb29xgwERIW8AgLaQNwBADdU9\nKsuWLdu6deuwYcPYzWeeeWbevHmjR482YmBgNgoLC+VyOWujR6UhQ94AAG0hbwCAGqp7VNLT\n07t37y7cjImJSU9PN1ZIYGaUL6KCHpWGDHkDALSFvAEAaqguVKKjo7du3Src3Lp1a3R0tLFC\nAjODtYmBQd4AAG0hbwCAGqqHfv33v/8dPHjwtm3bwsPDb9++ffny5YSEBCNHBuZCuVDx8vLS\n5CFSqVQulzs4ONRbUCAC5A0A0BbyBgCooaJQKS8vVygUt27d2rdvX3Z2dmxs7LBhw3x9fY0f\nHJiFwsJCoa3J0K/ExMSRI0eWl5d/9tlnkyZNqs/QwHiQNwBAW8gbAKCeikKlpKSkd+/eGRkZ\nkydPNn5AYHaioqI4juN5nuO4Tp061bn/qlWrWG0zf/58FCoWA3kDALSFvAEA6qmYo+Lr67tm\nzZrZs2enpaWxITqM8YMDs9ChQ4ddu3ZNmDBhz549bdq0qXN/4YqQ9+7dE9Y1BnOHvAEA2kLe\nAAD1VM9RiY+PLyws3LZtm/JGnueNEhKYnxEjRowYMULDncPCwoR2amqqp6dn/QQFxoa8AQDa\nQt4AADVUFyrXrl0zchzQcISGhgrtsWPHurm5qdzNw8MjLi6uV69exooL9IW8AWIqLKT//Icy\nMigujuojbxw/TosXU0gIffwxubsb/vgNFfKGxfs079Ofi34e7jF8qs9UsWMB86O6UPHy8tqx\nY8emTZsyMzMDAgLGjx8/btw4I0cGlkq5R+XmzZtq9rxw4UJOTo6Njeq/UjA1yBsgpg8+oG+/\nJSK6fJkyM8mweeP+fRo2jNhQVQ8PWrPGkAdv2JA3LNuxkmNvZr5JRIeKD7V3at/Jqe6JrADK\nVKfylStXfvfdd7NmzQoKCrp69eqcOXOysrLmz59v5ODAIrVq1UrDPQsLCzEAwIwgb4CYjh2r\naty9S9evU8uWhjz4ihUkTKg7d86QR27wkDcs29nSs0I7uzIbhQpoS3Wh8r///e/EiRN+fn5E\nNHjw4I4dO7788stIHGAQERERy5Yt27Bhg1QqrW0fiURSWVm5dOlSW1tbY8YG+kDeANHI5XT5\n8uObycmGLFTu3KFPP318MzXVYEcG5A1Ll1KZIrSb2jUVMRIwU6oLFVdXV5Y1mKioKIlEYqyQ\nwPItWrRo0aJFanbgeV4ikeCKkOYFeQNEc/s2lZU9vpmcTGPHGuzgixc/cfCsLJJIyN7eYMdv\n2JA3LFuK5HGhEmYfpmZPAJVULE9MRCNGjFixYoVMJiOiioqKxYsX43oXYEwcx6FKMTvIGyCa\n5GR1N/Vx4wZt2vTEFoWC0tMNdvwGD3nDsgmFipeNl4e1h7jBgDlS3aPy559/Hjt2bPny5QEB\nAdnZ2SUlJdHR0b/++iu79/z580aMEADMA/IGiKZaZXLxosGOvHAhyWTVN6akUPPmBnuKhg15\nw4LJeXl6ZVVVH2aH7hTQhepC5e2333777beNHAoAmDXkDRDNrVtP3MzIoKIiAywi/Pff9OOP\nKrY/fKjvkeER5A0LliXNquQrWRvjvkA3qguVgQMH1lwukOM4IwcHAGYEeQNE07kzbdny+CbP\n06VLFBOj72EXLCBh4cHp0ykhgW7fppAQ6tdP3yPDI8gbFgwTVEB/WJ4Y9CWTyQoKCho1aiR2\nICAy5A0QzYwZ5OVFu3fTvn1VW5KT9S1Ujh6lw4er2t7e9MEHtGoVXbxIrVqRs7NeRwYlyBsW\nTHnJr1C7UDV7AtQGyxODXu7cudOrV6/bt2+PGDFi165d+BmsIUPeANFwHI0bR2FhTxQqevr5\n58ftefOqBpJ17arvYeFJyBsWLFXyeC3vZvbNRIwEzJfqVb+wXCBo6Ntvv719+zYR/fjjj5eV\nr2MADQ/yBoisVSuys6tq6z+NpGfPqkaLFjR9ur5Hg1ogb1gwDP0C/WF5YtBLdna20MZV5Bs4\n5A0QmasrzZ1LHEdeXjRzpr5HGz6cEhNp7Vo6dowcHQ0RH6iAvGHBhKFfNpxNkG2QuMGAmcLy\nxKCXgoICoe3j4yNiJCA65A0Q37JlNHMmuboa5oKMfftS374GOA7UDnnDggk9KsF2wTac6hNO\nAPU0XZ64vLzcET8pQQ35+flC28vLS8RIQHTIG2AS8IuJWUHesFQP5Q/zZHmsjXFfoDPVhcqg\nQYNu3bol/Fiek5Mzb968a9euGTEwMA/3799nDRcXF3uD/IT5yIMHD95+++2srKy4uLhevXoZ\n8MhQT5A3AEBbyBuWSnnJr3JFedfrXUvkJeuC1vV1RS8laEF1obJ8+fJFixY5OjpaWVk5Ojrm\n5uauWbPGyJGBWRC+XQw+7is+Pn7z5s1EdPHixZycHGtra8MeHwwOeQMAtIW8YanSKtOE9vGS\n46wxNWPqzZY3xQkIzJPqyfQbNmzYv3//mTNnBg4cePfu3Q8//FAulxs5MjALwtAvb29vwx45\nNzeXNfLy8jIyMgx7cKgPyBsAoC3kDUvlZf14NLizVdWlh1IkKcK16gE0obpQKSgo6NixY1RU\n1K1bt4ho0qRJX3/9dX08fWVlZURERH0cGYygtLS0vLyctQ3eoxIcHCy0U1NT1ewJJgJ5AwC0\nhbxhqXq49IgLiGvl2GqB/4Jh7sPYRgUpcqQ54gYG5kX10K9mzZrt2LFjxowZnp6eV69e9fHx\nEX7e1tPKlSuVb0ql0lu3brGNc+fONchTgNHU65JfoaGPr2KbkpLSF2vvmDzkDQDQFvKGpeKI\nWxqwdGnAUiJ6N/tdYXu2NDvYLrj2xwE8QXWhsnLlyjFjxvTq1Yv938nJ6ZlnnjHI8yUkJPz+\n++99+/Z1c3MjItbDe/r0aYMc3JIcOnRozpw5np6eGzdubNbMRK/nqlyoGHzJr7Cwx4uEpKSk\nqNlTW1u3bp07d25QUND27dubNm2q7cP37ds3a9asoqIiNfvY2Ni88sorq1ev1iNM84O8ASLI\nyqJDh6hbN3rqKSM948GD9MsvNGwYDRpkpGe0aMgbDUFj28ZCO7sym5xFjMWc7CvaNytzlpeN\n1w8hP0Q5RIkdjji42i7SJ5FIOI6zs7NLSEjIy8sbPXo0W9Pp008/na7HNXoVCkV8fPzWrVu3\nbNnSoUMHiUTi4OCgyYUCf/zxxy+++KLm9osXL3bp0mX//v06h2SagoKCsrKyiGjs2LHbtm0T\nOxzVjhw5MmDAANZeunRpXFycAQ+elpYmdKqMGTNm+/btBjlsenp6ZGQku/Lx5MmTv/nmG60e\nLpfLAwMD7927p8nOZ86c6dSpky5Rmi3kDTCq4mKKiKB798jens6epVat6v0Zz5+njh1JoSBr\na/r3X4qOrvdnbACQNyze7sLdo1JGsfZ/m/x3lt8sceMxF40uNronu0dEwz2G7wnbI3Y44qj1\n+jvCUrNPP/208vbff/9dn8RhZWUVFxcXGxs7evTo6dOnv/HGGxo+sFGjRh06dKi5PSMjwyIX\nXBfmfpw8eVLcSNRQvoiKwSfTBwUF2draSqVSMmiPyuLFi1mVQkTCNcU0l5ubq2GVQkSnTp1q\naIUK8gYY1aFDxD6PEgn9/rtehcr27fTxxxQdTRs2kJNTrbtdu0YKBRGRXE7Hj6NQMQjkDYv3\nRI+KNFvESMzIPdk9VqUQ0eXyy+IGIyJxLhTaq1evM2fOTJw4UfMzxR49evTo0aPm9ps3b/r7\n+xs0OpMQHR197NgxIsrMzCwsLPTw8BA7IhWUh34ZvFCxtrYODg5m0ysNVahcvnz5hx9+EG7e\nuXPnypUrT2kzYiQgIKBHjx7Hjx+3sbFp06ZNzR0kEsmlS5dYOzk5Wc+AQRnyBlSn/BELCdH9\nOPfu0YQJJJHQ2bPUogW9+26tezZ+fL5FBh2SCvUEecMUNLFtIrSzK1GoaOS25LbQTqtMk/Ny\na64hXqdBnEKFiLy9vffv3//ZZ5/hY69S69atWaHC83xycnLPnj3FjkiFep1MT0RhYWGsUCko\nKCgqKnJ3d9fzgO+99161hS+PHDmiVaHCcdyRI0eOHDkSERHRvHnzmjuUlZW5ubmxZ0GhYnDI\nG/AE5Y+YcneKXE5z51JSEo0bR//5T93HOXyYHnW0Ummpuj2V5s6hUDEXyBuiC7ANsOas5byc\niLKkWWKHYx5SJI8zTCVfmS3Nbmqn9axaC6B6eWKjmTZt2vfffy9uDKYpWmlEgcme79br0C96\ncuEv/VcoPn369N69e6ttTExM1PY49vb2zz77rMoqhYicnJyExQ9wceV6grwBVYTc6O5OSgua\n0969tGYNnT9P77xDFy/WfZwjRx63e/dWt2dgIDk4VLVRqJgV5A0R2XA2vja+rI2hXxpSLlRq\n3mw4RC5UoDatW7cW2iZbqCivfFVPPSpCW//RX/Pnz6+58ffff5fJZHoeuRphyRqt+moAQDsl\nJY9Lheho4rjHdykvyvfnn3UfSihUnJwoJkbdnlZWj8eYoVAB0JgwTeWO9A5PdS9pAKmVT/w+\nmyNroNefQaFioqKjo7lH37smW6h07NiRNcLDwxsrD902EAMWKmydStb28/MbMmQIaxcXF589\ne1afI9f04YcfLlu2bPbs2bt37zbskQHgseRkElZwUvplh4ioZcsndlPv2jXKejQWpWdPejSx\nu1ZCT29REd2/r1msAA2dUKhUKCoKZAXqdwZ6slCx4WxaO7ZWs7MFE22OCqjn4uISGhrKzs4v\nXbrE8zyn/HuhaXjzzTednJzS0tKmTJliZWX4oteAhcqiRYuE9oIFC9zc3A4cOMBu5uXl6XPk\nmhwdHZWfDgDqRW0TVIgoOpqsrKqW56qzUFEe99WvX93PW22aiqEvIQVgkZrYKc2nl2b72Bh+\nFIaFEcZ6edl47Qvb19Khpfr9LZXqQkUqlf7000/VTuAmTpzo5OQ0b948owQG1Lp1a3Z2XlRU\nlJGRERxscldy5Thu8uTJ9Xd8QxUqCoXi/PnzrB0SEvL666/L5fKvvvrq9OnTPXv2HDhwoL6B\nAhEhb4CRqSlUnJ0pNJRu367ajedJzQ89yhPV+vev+3mV5s5RSgo96lgG3SBvNBDVrvnYxlHF\nspkgkPCSrMqqnt6nHJ7q4aJiGboGQnWhMn78+KSkpJiYGOWfyadMmUJEKhcXh/rQqlUrYfL3\nxYsXTbBQqW8eHh5eXl73798n/QoVKyurSZMmff311zY2Np9++ilbs//kyZN5eXm+vr4m2FVl\nppA3wKiEQoXjVFzPpFWrqkLl4UNKT6918WK5nI4dq2p7e5OqNcerw8JfBoW8YXnkvPzltJd3\nF+4e5DZoV+guBysHwqVUtJRema4gBWuH2oWq39myqS5Ujh07lpKS4qTmoldQ/1op/UaYnJw8\ndOhQEYMRS2hoKCtUMjIy9DnOV199NXXqVD8/v6CgILaF4zg/Pz8DhAiPIG+AUT26YBEFBVHN\nK021bk3CKn/JybUWKmfP0oMHVe3+/UmTIazKhYreqxEC8oblOfLwyLYH24joQNGBA8UHRnqM\nJKLGdo8LlbvSu6IFZyZSJY9zS5h9mJo9LZ7qpNylSxdkDdFVK1REjERE7du3Zw1fX189D9Wh\nQwehSoH6gLwBxpOdTcJ1nFRekF55o5oVirWdoEJEj9YfJ0KPigEgb1ieqxVXhbaMr1pXM9oh\n2o6zY+0gO3wX18HN2k1oN9hp9IzqQmXatGlxcXHZ2dkymUz+iJEjg4iICIdHC/Y32ELlgw8+\nGDt2bJ8+fbZt2yZ2LFAH5A0wHuWU2FrVt7hyoaImf2o7QYWIXFxI+N0EhYrekDcsj/IVP8Ls\nqnoD/G39d4ftftb92SUBS172elmk0MxGN+du8/znhdmHTfOd9pz7c2KHIybVQ79GjRpVWlr6\n/vvvK2/keax7Xb+kUumWLVukUum4ceMcHR2tra1btmx57tw5Irpx44ZEIrGvc91Mi+Pr64sS\nxVwgb4DxKHeSqOxRCQ8nJycqKyOqvVApK6NTp6razZo9MUtevbAwYpO/MzJIKiVbW00fCDUg\nb1ielEqlQkVp2NJQ96FD3RviIHbdLA9cvjxwudhRiE91oXLr1i0jxwFENHv27HXr1hHRsWPH\nfvjhByJq1aoVK1SkUunVq1fbtm0rcogN1aFDh9555x0vL6+NGzeGh4eLHY6JQt4A41Gz5Bdj\nbU1RUXTuHBHRjRtUUfH4ivKCP/4giaSqrWF3ChMWRn/9RUQkk1Fm5hOzVkBLyBuWR+hRcbV2\nxTLEoCfVhYq3t7eR4wCFQsGKEyI6efIka0QrLWVz48YNFCqiUCgUkyZNunPnDhEtXLhwx44d\nYkdkopA3wHiEmfR2dtS8uep9WrWqKlRkMrp2jWrmT+VxXxpOUGGqLfyFQkUPyBsWhic+rTKN\ntZvZNVO7L0DdcGV6U/HPP//cf3SR43bt2rHG4MGDra2ticja2joqKkq04Bq2f//9l1UpRKRQ\nKMQNBgCIiMrLqxqtW5Odnep96pymIsykt7Kivn21ePannnrcbngjcgHUuCO9U66o+ng28OWq\nwCBQqJiKI0qLz/R/NAjhqaeeOnjw4IwZMw4ePNhK5fAGqH/K/zSxsbGaP7C8vPznn3++efOm\n4WMCaOCWLiUnJ3Jzo2XLat1HfaHC83T5clW7bVvS6nf9ESNoxAhydqZJkygmRosHAli6J2bS\no1ABvake+gXGl6g0CKG/0mjpQYMGDRo0SIyI6paTk1NeXh5m6cMeavunUU+hUMTGxp45c8bW\n1vbo0aMxOJsBMKAxY2j4cOI4dRPZ1RcqHEfPPEP79hERvf66ds9ub0+7d2v3EICGIbXy8QVA\nGviVCg0oX5Z/tuxsF6cuXjZeWj2wRFFiTdaOVo71FJgRoEdFR6WlpbNmzRoxYsTZs2f1P1pF\nRcXx48dZOzg4OCIiQv9j1redO3c2bdq0WbNm8fHxYsdS3YMHDx4IF3HTgEwmu3fvnsq7Kioq\n/vzzT9YOCgqKjIzU8Jjp6elnzpwhIqlU+u2332oeDABoxM6ujuW2/P1JuKjr1asqdtixg3bu\npGPHaMoUw4cH0CChR8Xg7krvRl+NfubWM9FXo/Nl+Zo/8If7P/hc8PG96Huw6GD9hVffUKjo\n6MMPP1y7du2ePXuGDRum/7yF48ePV1RUsHY/reZ0imft2rUymYyI1q9fL3YsT9i6dau/v3+j\nRo02bdqkyf6ZmZmRkZGNGjV66aWXat578uTJ8kej4bX6pwkICGDzi4jooprrzQFA/Rk4sKqh\ncrE+e3saNYp69TJmRACWDYWKwR0rOZYrzSWiHGnOL8W/aP7ARXcWSXhJqaJ0SsaUUkVpvQVY\nv1Co6CgpKYk17t27J5VK9TyaboOLxJWbm8saNjamNYAwLi6usrJSKpWuWrVKk/03b96ckpJC\nRNu2bfv777+r3aty7pAmHBwcmj9ajOjy5cuYhQ8ggnXr6J136M036fvvxQ4FoEEQLqJiRVbB\ndsHiBmMZPKw9hPZtyW0NHyXn5RmVGaydI81Zd2+d4SMzChQquuB5/tKjxTGbNWum/3UYhbNh\njuP6arX4jHjy86v6H01qccnbt2/fvl31MQ4ICNDkIX7C4BCiw4cPV7tXqCE5jtO2s0tY/6Cs\nrAzXCgAQgacnrV5N69eTZtnADJw9S//8I3YQALUSelSa2DWx57AmngEod0wpd1ipZ81Zj/Yc\nLdxclbvqvuy+gSMzChQqukhNTS0pKWFt/Rfjun///j+PvnhatWrVqFEjPQ9oBFKptLi4mLWN\nU6jwPK9Jz5Vy35SGdYXybsr9J0T04MEDdsFNIoqOjvb399co1keUL4OTXNu1sQEANLRkCXXu\nTB060EcfiR0KgAplirK70rusXdu4LwUpyhRlRgzK7AXbBVtzVSPJNS9UiGhL6Jan3Z5m7UJ5\n4crclYYPrv6hUNGF8kmn/oXK0aNHhXFB5jLu6/79+zzPs7aPT71fd/bs2bOBgYFubm5ffvml\n+j11GKnVrFmzkJAQ1j558mRZ2eMEevToUblczto6zB1q3bq10EahAgD62rq1qrF4MWVnixoK\ngAqplak8VZ0bhNmpKFRuSG6EXQpz/dd14Z2Fxg3NbPDEz8ic4XXBa3Tq6ApFBRHZcXZNbJuw\ne4WRdZqwIqsVjVdYPTrVX5+3PltqfnkDhYoulOdG61+o6DwLQkTCuC8ySo/KqlWr7t69W1FR\nMWfOHDWTPRQKhTB3yNPTs0OHDhoeX3jblZdfI73nDin/baBQAQB9detW1SgvV3cBGQCR3Km8\nI7RV9qh8lvdZemW6ghQr7q7QagGrhuNEyYkNeRseyB/serBrb9FetlF4M3OluVpNi2/j2Gas\n11jWLleUL8sxv7yBQkUXwgQVMmihYmdn18tM1p8pKCgQ2saco/Lw4cPs5UND+gAAIABJREFU\n2n9HPH/+vBBYbGyssOhWnZSLEOXiRPinsbW17d27t7bRhoaGurq6sjYKFQDQ19KlZGdX1f7f\n/1SvuQwgnkiHSDvOjog44vq49qm5g9DfoiBFWmWaMWMzF5crLgtt1qNCSt1TPPGpklQVD6vd\nsoBltlzVSu4bCzbekNwwRJjGg0JFFxcuXGANJyencJWrXmosPT1dmGbdrVs3Z2dnfYMzCuUe\nFSMM/QoNfXzRqNTUWj+iOvdN9evXz8rKqtpBMjIybtyo+jx37drVxcVF8wMyHMe1bNmStW/f\nvl1aaq6LAwKASQgJeXzJF7mcliwRMxiAGpraNU2KSJrlN2t/s/3dnbvX3EEYwkRE5jgMyQiU\nZ6GE2led/Dwxn16b0V9E1My+2RSfqrwh42WL7izSO0ajQqGitYqKCmFdqZYtWwonuLpRPrdW\nPwvi9OnTCQkJwpQJcd2//3jtCCP0qISFKX1EU2r9iOo8UsvHx6dNmzas/e+//7IyTPN/GjWE\naSoKheLy5cvqdwYAqJKTQzNn0ty5VFT0xPb33iPh96xdu+jRah8AJiLGJea/Tf47xH2Iynsb\n2zYW2tmVKFRUUC5Umtk3Yw2hYiEibXtUiGhxwGJX66rxHbse7Pqr9C/9YjQqFCpau3LlCrvQ\nIRli3Jdw1XNSezb8+eefd+vWbfDgwa+++qqez2gQRp6jokmhojy9pGnTpsI1TDQkvPnCRBeD\nXNwG01QADKm8nF55hSIjae1asUMhksnozTepRQt6/30DH5nn6YUXaP16WrWKZs584i5/f3rr\nrce7LVhg4KcGqE+N7ZQKFfSoqCJ0mNhz9oG2gaytvDJBaqXWhYqfjd9M36pMwhMflxOnd5jG\ng0JFa4Zd8ktYjDgwMLBz58617fbTTz+xxpYtW4Rr2IvIyHNUNClUTpw4odsl5BnlUoT1pVy7\ndo3ddHV1VfNPox4KFQBD+vZb+v57unGD3n6bah8Fqs7ly9S/P/XrR0pTDXW0bx99+ildv05x\ncXTmjL5HU7ZrF50+XdWu+TLnzCEvr6r2b7/RoxVEAEzfEz0qKFRUEXpUQu1DhQW7lId+aX7N\nR2VzGs3xtqk6W/ut+Lekh2aTN1CoaM2whUpcXNyMGTOGDx++d+9eNZd4DwoKYg2pVHrlyhU9\nn1R/yoWKEeaoBAcHCzPjaytU9OwA6dmzp3DhTnaoUaNGsZvTpk2ztbXV9oAMChUAQzpxoqrB\n86TbTzavv06JiZSURNOm6RuM8qAspaUg9SWT0SKlQeQTJ1bfwcOD5s17fHPBAnq0WDyAicPQ\nL/Xuy+4XygtZW7k48bXxdbN2Y22tLqUicLd2f7fRu8LNednzhIUNTBwKFa0ZtlBxdnZet27d\nnj17OnXqpGY3UzvfNfLQL1tbW6FUq61QEaaU6HAJeSJycnLq3r278BQpKSnz5s07derUH3/8\nsXz5cp2iJiLy8vJq0qRq7qAp/MMBmDfhQ2RvTxERWjywooISE+nSJTp5smpLmd6XnHt0/SUi\notrnzmnt22/p0TIe9NRT9MorKvZ58016lFjor79o716DPTtAfXK0cvSyqeoPRI9KTcoT5UPt\nQpXvEm4qX6xGKzN8ZwiF4tmysweKDugaplGhUNGacLrZqFEjPz8/Ivrzzz+bNWsWGhp69OjR\nenpSUytUhB4VGxsbDw8PIzyjMPrr3r17NZfPun///j///MPa0dHRwoA6rdS8RH3Xrl179uzJ\ncZwuET8i/Nvl5eXl5OTocyiABq2ykq5fr2pHRVHtXdDVyWQUE0P9+1Pr1iRciEn7BcerUxqS\narBCpbycli59fDM+nlQus+7oSHFKo8wXLiTTWGcFoE7CuTIKlZqUe0uqXYhGuFmuKM+R6nIu\n4WjluDhgsXDzXJl5LMWBQkU7+fn5wrmmsKDTnDlzUlJS0tLSZlab9Wg4JluoeHl56XkeryFh\nhWKe52uuUKx8CXmdJ77XnKZiEO3atRPahYWFhjosQINz/TpVVla1terNvnKF2A8ZykOk9L+6\nblAQCYNCDVWobNjw+JLzXbrQ88/XuufEiRQZWdW+epW++84wAQDUM6FQKZYXP5Q/FDcYU/NE\noWKnulChukZ/yXjZqtxVr2e8fqWi+kyBid4Te7v0JiI3a7dRnqMMEHH9Q6GiHeUVZoXiQZjb\ncOnSpczMzPp4Xj8/P6GXwBQKlYcPq5KLESaoMOrn0ycpTSfVuVDp2LGj0Dt09OhR3kDDvqdM\nmRIYGEhEzz33XIsWLQxyTICGSHkeyKPfiTQSGFh9i50d9eypbzzW1tS0aVVbt5n91RQW0ooV\nj29++CGp+RnIxuaJ1cYWLaJHq4kAmDLlaSpZ0iwRIzFByit6KS9JTETN7JoJ7WJ5sZqDrL23\ndm723C/zvxx4c6Ccf6Kv1YazORJx5GTkydstb7d0aGmgqOsXChXt+Pn5CR0IsbGxrNGnz+PL\nrypP6TYsoQMnJycnLy+vnp5FQ8Jl2gcPHmycZ1RfqAjXdXFwcOjVq5duT2FtbS2M/iosLJRK\npbodp5qQkJDbt2+npqbu3bvXOL1PAJZJeZ2u6GgtHujjQwEBT2zp2pW0v4SrCs0enTrk51e/\n4IkOPvqIhEtUDRxIffvWsf/IkdSxY1U7O5u++ELfAADqXxM7XPOxVmp6VJ73eN7f1p+IQuxC\nYlxi1BwkoTiBNbKl2SWKkmr32nA23Zy7+dgY6Vdm/YlQqHzzzTejR49evXr1gwcP2Ja7d+8K\nKyyZuKioqI0bN/br1y8+Pn7IkKrrGdXTkKFqTGr01//+97+vv/76+++/X6H8+199Ul+ozJ49\n28/Pz8bGJj4+XodLyAsWLFjg6+trZWX13nvv2dnZ6XycahwcHEKU592C9sw6b4BhKOc9rXpU\nqMZQMf3HfTGhSj956tmpkpPz+OIwHEearOHBcfThh49v/u9/egVgiZA3TBAW/lJDmEzva+Mr\nXKKRCbANuPrU1aMRR5OfSna3dldzkOSKZOEh6vc0C8YuVFasWBEXFxcREbF///5Ro0axeQWl\npaW7d+82ciQ6mzBhwpEjRxYuXCj8Ot6lSxdX16q/p8TEREMNGarGpAoVR0fHV199ddy4cWqW\nVDYs9YVKhw4d7ty5U1xc/M477+jzLO3bt8/KyiooKFi8eHHde4vkzp07WVkNq7vcAvIGGIAw\n9MvbW8VoLvXqqVAx4Hz6+HgSlgkZNYrat9foUQMG0MCBVW1hHBoQkYnljYzKjDOlZ8xlQdhq\nHsgfHC85XqGoY0HwCkXFnyV/3pfdV78bLqVSGxkvy6jMYO1qM+kZD2uPWNdYFyt1v8bek93L\nleayditHfVemNQXGLlS+/PLLXbt2ffDBB0ePHrWyslq9erWRA6gPtra2wnCju3fvXtL/OmKq\nmFShYnw+Pj5ublWLiNecTE9E1tbWjo6O+j+RnZ2dcdYx0823337btGnT4ODgzz77TOxYjMci\n8wZop7CQhBmAOqwLrzxUzM2N1C4HrwVDFSopKfT111XtapNP6rR1K82cSW++SRs36h6AJTKd\nvJFQnNDscrMu17tMTK9xVRyTl16ZHnUlqueNnl2vdy1VVF9yU1CuKO9wrUOvG70ir0SmVaap\nOSAuTl+bjMoMGS9j7WrjvjSXXK50CQ0UKjrIy8tj84mtra3Xr1+/Zs0aDadbLFu2jFNlz549\n586Jv8Ka8uivepqm8tRTTwkXPWyAhQopLfzVkBf5ff/99+VyuUKhWCuMEmkALDVvgBb+/vtx\nW4dCRXmoWGysFksbq2eoQmXLFhImxU2aRM2ba/FYb29au5bWryd/f90DsESmkzfW5K5hJ6Df\nFXx3V3pXhyOIaF72PPYL/YXyC5/c+6S23X4v+Z2tMZUvy/+l6Bc1B1TuUcmTiTzh1qQol20q\ne1Q08USh4oBCRXutW7fesGEDGxwVGRn5yiuvTJ48WSKR1PnAmTNn/q1K37599b/qov6MME3F\n0dEx4tEFzi5fvqwQrgbQYAwaNIg12ms4KMLi3Lp1S+hNEq6A2RBYat4ALSj/ANStm9YPb9Xq\n8dn/+PGGCYkMV6gof2u8+27t+4EWTCRvVCgqjpceZ22e+MSH9bXiTn04X3Z+54Odws2Pcj8q\nkBWo3PO25LbQFq6hrpKPjY/wS39bx7aGCLMO+bL8w8WHTX8p5FD7UDuuanJsLxcdlwWyvB4V\n4o3rr7/+CggI8Pb2zsjI4Hm+rKxswIABnp6eOkfywgsvzJw506Ax6kKhUPg/+jXLxcWlsrJS\nzc4rVqzo3LnzsmXLFAqFVs+iPAXwxo0b+oVsfiorKz/77LPly5ffv39f7FjE8YXSqj4ffvih\n2OEYj6XmDdBCx448EU/Ecxx/964uR8jN5deu5RMTDRyYl1dVYM2b63iEkhLezq7qIOHhBg2u\nQTORvHG4+DCdI+G/CWkTdHt2UbyZ8aZy8HSOZmfNVrnn25lvC/ucKDmh/rBZlVkLsxd+du8z\nmUJWD1E/IV2S7n3Bm85R2KWwh/KH9f10ekoqTpqSPuWHgh90PkKnq53Yv4LNPzbl8nIDxiYW\nI82EFnTu3PnmzZvnz5/38vIiIkdHx0OHDh06dOjMmTNGjsSwOI7r16/fli1biKikpOT06dM9\na1mkf8+ePfPmzSOiM2fOxMTE9K1zAUolrVq12rVrF2snJycLHSwNhK2t7RtvvCF2FGJS7qzT\n+XIx5shS8wZo6v79qis2ElGrVvToolLa8fOj+rgmb2ho1ZrCaWkkl6u+kLx6588/vpBlQ/pc\n1zcTyRvVulDMq0dFeZgWsyFvw1t+bzWxbVJtu5p1dVUeNj4w3iAR1imhOIH1AqVIUvYW7h3n\nNc44z6ubPq59+rj2qXu/Wsh5+eWKqsv9RdhHOFg5GCguMYmwPLGzs3OPHj2cnZ3ZTY7jnn76\n6bi4OONHYliaTFORyWQLFy4UblZU1LGGRjUNfD59A6dQKITrWnp6eja08W+WmjdAI0lJJAx2\nNbVTeWH0V2Xl44vKa3sEYSGQ0aMNExUQkWnkjSPFT4wGz6zMrHP5LNPxTqN3lgQsednr5QFu\nA9iWCkXF0pylNfcU1tV1snJqZKvTTwn1I8L+8U+65lUl6uB25e0yRRlrazXuS0GKC+UX6lyx\nTRS44KPBCNcKpNqnqWzevPnatWus3aJFi4HCspKaadeunbAmcmFhoU5hgrn6559/hOta9unT\nx1qHH24BzJTyDGaTLVSIKCNDlyMEBlJSEr31Fu3ZQ310/zEVTNB92f1/yv5R3jLWc6wZ/c5t\ny9kuDlj8Xch3Xzb9Upg+salg0/WK69X2TJVUzZ8MtQvlyIQubdzdpbuTlRNrVysaLc//t3ff\n4VHU+R/AP1tSNr2RQggQIiEQepQiGEHKKRIP0QDCiQUFTuCOpkACUgIiCIcC4ml4EO5+iKIe\nVSKKlNBJgFASCCQU00iF9N2Und8fs5ldQpKd3ezuzCbv1+Pj893ZmdlPhs0385lvM26ACkPM\n6LTRvW/07pTc6WrlVf0HWBYSFZMJCAjo0qULW75w4UJpaf1hW0qlcvly7XOIlStXGroISYcO\nHaZMmUJE3t7eU6dObV68YGV0m+laVb8vAO1swv7+oruV799fU5BKyb9+Pxm+Bgygzz+nV181\nVVAgEkfLjqpJ0xg42WPymS5ndgbuFDYk4wTaBk710tx11DA1i7MX676bV5PHrYBu9HRVZmIn\nsRvsNJgtZ1Zn3lTeFDYeszIuUblfdT+uJI6IimuLZ2XMMktkzYBExZS428fq6urjx4/Xe/fL\nL7/MqFsH4Jlnnhk7dqwRHxEbG5uVlXX//v2uXbs2I1IQwLVr10aNGjV27Nj79+8bcbhuM51u\n8x1Ayzd2LO3fTzExdOoU2YvsafSYMbR+PUVE0O7djy1UD/D4I/wJHhMGOg6UWu1912LfxdxS\ngz8/+jmhIoF767EBKiJLVIhouLNOz/wW3fvLuLmJ/Wz8uN568WXxTc8ubXnW+gsjiIyMjKZX\n8GhimEpxcfHq1au5l6tXr+Y6cRmqbdu29gL9qS4uLl62bNnSpUtF0vFMqVRyuZ/4vfPOO3Fx\ncXv27JkzZ46hxyqVytOnT7Pl9u3bBxu0zAJACxARQYsXU8eOQsfxBImE5s6l/fvptdeEDgVE\nh7sttpXYGj3hrEj42PjM9p7NlhliorKiuLcMGklvebqJypFSq+/9FVcSNz9r/rnyc0++xSUq\nTlKnQDu+z03sJHbRvtrh09HZ0VwzoBggUeFr06ZNHTt2bN++/X//+9/G9hkyZAjXm+vO43Pq\nr1u3rrBQM/v48OHDrfSJ+NSpU5cvX75ixYr3339f6FgoPT09KCioffv248ePFzoWXrgvwIkT\nJww99vTp05WVlWwZ/b4AAMTvXtW9NFUaWx7oONBR6ihsPM0332e+p9yTLR8pPcLd9HMj6UmU\nLSq9HHp5yb3Y8vHS47VMrbDxNMe58nMvp728Pnf9kFtD7lc91jujQl3BrWbTXdHdoJFC07ym\nBdpqEpukyqQfHv5gqoCbD4kKX59++qlara6pqdm4cWNj+7i5uU2bNo2IZDLZ22+/zW3Pzc39\n/HPNeq4SiUS3acWKKJXK/fv3s+WUlBRhgyGiTZs2ZWdnE9Hu3bvT0tKEDke/0NBQtlBUVJRl\n4OxArXZiYgAwzLp11L8/ffwxMYzQobR2ur2Mhjlb5dPJelxlrot8FnEvuUYVEXb92v1wd0R6\nxPrc9QwxUpK+4KxZCuJR7aPEikRhY2uOa5XXGGKISMWoTpWd0n0rRZnCtYT0VPQ06LS2Etvl\nbbWDqJdkL6lmqpsdrGkgUeElNzeXvScmIi8vryb23Lx5c2JiYlpamu4QlJUrV5aVacaZvfba\na08//bT5QjWfU6dOcfMpDxgwQNhgiOi3335jC3K53NvbW9hg+GjO7NJcoiKRSAxaewcAWpEL\nF+jDD+nCBYqJoYMHhY6mtcup1vYVH+li2CSfojWjzYwA2wC2nFCRkFWdRTqJioQk3IN5Ad1S\n3Xrj7hsHiw/Oz5p/oPgAtaDeX21t2nJl3fyQiLgRREQ0yGmQoWee5DGJG3+frkrfWrDV2BhN\nDIkKL1evaudr69lTT54aFhbWUacj9b1792JjY9myTCZbsWKFGQK0BFHNOpWdnX3jxg223K9f\nPxcXF2Hj4cPoROXhw4eXL19myz179vQxbrU7AGjxdGebRKIitDc93mTv6V91e7W/Y3+9+1sF\ne6n9Wv+1bDnILshb7k06Xb/8bPwUUkWjB1vKgUcHuLaFB9UP6PEWLatOVHQbrHR73BFRiH3I\nhnYbuiu6T/ea/ob7G4aeWUrSVW1XcS9jHsSUq8ubE6qpWHpleiule1vJdeDhacmSJSqVii2/\n88471jtbl3ge6l++fPnHH3/kXlrLgB+jE5WjR4/W1mr61FrLDwsAAhg4kOzsiP2L08i6w2Ax\nHWw7pIWm5Vbnck0QLcME9wkuUpebqpsT3CfYSGxUjCqrStOZ2aB+X8W1xTeVN/s49OFWaDEV\n3VSEnZu4k12nTnad2CaIs2VnK9QV3OIqIlHD1FxXXg+yDXKWOTexW0fbjhKSsL2/6rWoENFs\n79nchAdGiHCNGOQ06HTZaSLKqc7ZmLdxke8ivUeZG1pUeLl+/TpX1tuiouvatWvfffcdW1Yo\nFEuXLjVxZJZSVFR06ZJm1aoePXoI+FB/y5Ytffv21R3nYy337iEhIba2murY0ESFK1vLDwsA\nAnBwoIEDNeX0dLp7V9BogGwlttaSpZTWlr59/+2ht4ceLT2qd+dRrqPmes9luyHdU93jmi/4\nT/mVUZXRJaXLgNQB/W72UzEqo8N+UhVTdbLsJFv2t/HvZt+NLXO9v1SMittBJKqZ6sG3Bve5\n0adzSud7Vfea2FMhVXC9v55MVJpvdVvtzdXa3LViWKseiQovXNcvuVxuUJNIVFSUWq35BZ4x\nY0a7du1MH5xFHD16lPtBhO33pduWQkSOjo4DuT/M4mZjYxMSEsKWb9y4UV3Nd6Qat3ioQqEI\nD7fuCS4BwLx0n2UcseIuLmBhszNn7yjccbz0eOTdSIPmxXpUq12ugH+LyoHiA7nVuUR0pfLK\niVKDZ8Jswtnys1yfJd0eX2Lu/XWm/Mz58vNElFudu/fR3qZ35i5ydnW2Uq00bSTPOT03ynUU\nW35U+2hN7hrTnt8ISFT0q62t5Sa5Cg4OtrOz43lgYmLiwbpewq6urgsXLjRLfBYhngEqbm5u\nui/Dw8O5Zgrx43p/qVSqW7du8TxqwYIFHTt2tLe3/+yzz5ycnPQfAADid/UqTZtG//oXqU26\nZMGIEdoyEhXgJ0WZsqNoB1uuVFfWkgGJSk9Fz852nYnISeo0zn0cz6N0h7JkVJtyPTTdRTaH\nu2hvV15wfoFbbVNsyz5y01gTkd5prLlERU3qpptfjPNJ20+4C7UpfxM7X4KAkKjol5aWxi1h\noTvMQC/dO9EPP/zQ09PTxJFZEDdAxdbWVtiH+oGPr/0s+LB+gxg3TCU0NPTu3bvl5eUzZsww\nT1wAYFlKJY0YQd98Q/Pm0ZdfmvLMTz9N3NOco0dNnAWBKSRUJHRL6fZU8lPiea4fnR3NtaJM\n85pm0KARhVRxMeTigaADN0JvdLXn2+XE38afK3NDXEyCu6oSkui2onjJvXo79GbLVyquiKFT\nE8eg+Z1151W7W2X67p29FL0meExgy5XqyhU5Ak8BhcH0+uneUBqUqIwePbpHjx7Xrl0bOHCg\nEYuRN6Gqqmr+/PkJCQkffPDBm2++acIzN+jevXvcQiUDBgxwdBRy1apOnR77HbauMRv1EpUJ\nEybwP1YqxWMFILp4ka5coYgIatNG6FDM79//psOHadw4esPgGWwEUFNDd+9Sp04kk+nf+eRJ\nysvTlE27DJRMRkOG0N69REQFBZSURH37mvL80GwfZX10Q3mDiD7484Nbobya1k+XnU5Tpf3V\n7a9uMjf9ez+hXF3+08OfHtQ8aPDd0trSfY/2sWVnmXOUb1SDuzXBWeY82nW0QYf42+okKqZ7\nZl9cW8wtk9LVvqvuZL5E9JLLS5cqLhGRRCIxqNXI3AxKVB6b+MsMw1SIaIXfih8f/sgupbKt\ncNs8n3nBdsHm+CA+kKjoZ3Si4uLicvny5czMzICAANPeZX777bebNm0iosTExKFDh5p76It4\n+n3R44mKt7e3QXMbCE73+3PlyhUBIwGrdPw4jRhBNTX01FN0+TK17H6Af/xBf/87EdG+fdSj\nB3XvLnRATSoupkGDKDmZnnmGjh0jvU9zdDtlPfusiYMZPlyTqBDRH38gUREbG4kNW7itup2m\nSnvK7qmm99/zaM9rd15jiOmT3+d8l/Pc4fz9Nf2vPDs7zfOe10ZuiYcgj7WomC5ROV52vIap\nYcu6/b5Yc73nXqy4eK3y2gLfBZb5MXniJhq2kdgE2OiZfUF3xgIzJSpBdkHve72/JX8LEdUw\nNVsLtnJzUlsentHqZ3SiQkQymaxDhw4mfxZeVKRpsqypqfnss89Me/IniWpZ9M6dO3PlYcOG\nSSQSAYMxVEBAgIeHB1v+7bff0tPThY0HrIlaTXPmUE0NEVFaGm3YIHRAZsbdajMM1a23K16H\nDlFyMhFRQgKtW6d/f65SlUjI5LO969bSGKYiPkOdhnJlvflDFVM1L3MeOx3t5YrLx0uPG/px\nNUzNsdJjfPZsI28z13uuoec3jpvMjRuMYcKuX48NUHGuf7viIfeIeyous0fmrDazTPWJJsHl\nG+1t28slepoQmlhKxYQW+y7mJkr2kHmY6VP4QKKiH5eouLi46K7kKKDXXntNVte74Ouvv753\n7575PothGG56XFdX12eeecZ8n8XHU089xQ6SsbW1/eCDD4QNxgjjx49nC9XV1R9//LGwwYA1\n+eEHSkrSvly3jgoKhIvG/LiGXLmcBgwQNBQeQkKIe2iyfj3l5ze1c2Gh9p+yVy/T9+Lr0oUC\n6h7KnjpFShPPCwTNpPukX/fGukFfF3zNjUOQklS3xxRPcok80j1S724Skqz1X9v0Ih6mxTWq\nmLBFhRugIpfIn3d63lSnNauS2pKCGk1lzmfaNF8bX24RGDO1qBCRn43fgaADo11Hz/OZN8fH\nlIMXDIWuX3qUlZXduaP5HnTv3l0kz++Dg4Pfeuutbdu2EZFKpVq6dOmOHTvM9FlXrlzJq+tL\n/fzzz8vlAn9nJBLJ77//Hh8fHxQUVG9gvVWIjo7evn07Oz3D999/v3DhQkOb6aA1qq6memlt\nSQmtXk3r1/M9Q2Ii3bhBr7xCrq4mj870MjPpxg1NuV8/cnERNBoe+vShMWNozx4iotJS+uST\nppq8dMe4m6mNetgw2r6diKiigs6cMX2jDTRDX0Vfd5n7w9qHRHS07Kia1NJGnhqXqctWPdAu\nFh7bIZZbFcQg3wV+N81rGnc33KBuim6h9oatZ91M7Wzb3VLdIqKCmgKlWmkvtW/mCTOrM28q\nb7Llfg79XGSirzeI6PFWET4L0UhIEmgbmKxMJnMmKkT0vNPzYkj20KKiR3JyMrd+iKhuKJct\nW2Zvr/mt3rlzp+6SlKYlqgEqLFtb2+HDh1tjlkJE/v7+s2ZpGp3VavXJk+JadgpEatu2BoZc\nb9lCGfym9YyLo/79afJkCg+nWhENIW2U7qrq4qh29Fu5UjuM/quv6P79RvfU7Y5lpulAdC8a\nlqi3uDJ1WRPvyiSyoc6a3l9FNUXs8O4GbcjdwC42QkThTuHver5rXDxSkg51HhrpHtnEfxbO\nUkinRYUhJrvaBN07/yjRuV15YoCKaN1VaWfu4rkQDbdbmbosryaPiCrUFRXqCnOEJzgkKno0\nZ4CKWQUEBHAdn2pra6Ojo830QWfPnuXKIklUrN3ChQvZLMvZ2RmXFHjRvdcMrbufUCpp2TL9\nx9bU0OzZmkf4V69awXgPssitvMl160bcHIwqVVP/NNxPZ2dHZporO1bCAAAcjElEQVTtfdgw\nbVc0DFOxIKVaOfT2UOck5+G3hzex4Lru8InGhqkU1BSsy9OOd1rtv7rB3ayXySf+0p3u+ckB\nKqKl2yqiO/VwE+pN/LX74W6vq15trrb56dFPpo9PaK0uUdm1a1e/fv2mTZum1Om2e+jQoREj\nRsyZM+fJxcKzdf6o9+rVy0JR8rNo0SKXuh4R+/fvP3PmjDk+JThYMyddaGho1658p0iHJri7\nuycmJv7888/Jycnc5QVoyqhR2sKBA8QtO7tjh7aLVGO+/Za4NZ26dSN/g/u4WxrDaBMzJycr\nGKDCWb5c+0/z3/9qhtfXc/cu1XUnpoEDycHBLJH4+moT2osX6eFDs3wKPOGnRz+x493/KP3j\n15JfG9uNzzCV1Q9Wl9SWsOVXXF951tHUs8MJzbQTfzHEcCmfk9Spv2P/Zp7QYh7r+sWvRSXE\nPoQryySypTlLK9WVFeqKlTkrTR+f0FpXonL9+vXJkycnJCR8880333zzDbuxuLj49ddfP3Lk\nyOeff75iRf11bcaMGcMuG9K7d++BAwdaOuImeXl5zZ8/n3u5aNEic3zKsmXLPvnkk9mzZx88\neNAc52+dPDw8xo4dGxCgZxZCAI2336ZTp2j3bvr5ZwoMpGnTNNtra2nx4qYOrKyk5cu1L1eu\nJPEvyJOSQjk5mnJ4ONkasPacwNq310ypTI3/0+i2b5i1QZU7eW0tpaSY8YNAx+GSw1y5ibmS\nOtt1bm/bni2fKj+lVNef8ODPqj+3FGxhyzKJbFXbVdTimHbNx5zqnJxqTb0R7hxu0JqVwjJo\nERXW3zz+9oLzC1KSvu35dohdSKoyld1uybkQLEb0f7FMKjo6uqZGM8G2SqXiClzryoYNG3K4\nP5BERNSzZ8/U1NTDhw+fOXNGxmcZL8uaM2eOj48PW46Pj4+LizP5R9ja2i5atGjDhg0imfGs\n9SgrK0tOTmYYRuhAQBwGDaLISGJHpkVHaxdR2bOHLlxo9KjNmymr7g6gf38aM+axd8vKKCWF\nxPYds9itvDlERZFz3b3Cvn107lz9HSzWq+3ttzXNO/7+ZFXrTVkvgx7qc32TlGrlqfJT9d5d\nnrOcy14muU/qrhD3OkJGMW2Lirfcm1uRZrLH5GaezZK4RMVd5u4uc+dziJPU6Y/Of9T2rf2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CunLlSmpqamFhoYeHR3BwcJ8+fSwfAwBY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\nUQEAAAAAANH5f5MEJthGmQUWAAAAAElFTkSuQmCC",
      "text/plain": [
       "Plot with title “Approved Drugs in\n",
       " Eli Lilly Nederland B.V.”"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "image/png": 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l3iZHozK7zqVwEGJtOLiewAGjdu3Frnm2++ycnJEaetXbt2586dxfyzkSNHyqr5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\niAyHhQoRERERERkOCxUiIiIiIjKc/wcq3kMy4E2yIgAAAABJRU5ErkJggg==",
      "text/plain": [
       "Plot with title “Approved Drugs in\n",
       " Novo Nordisk A/S”"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "# visualize\n",
    "options(repr.plot.width=9, repr.plot.height=3)\n",
    "\n",
    "# Evolution\n",
    "par(mfrow=c(1,3))\n",
    "for (i in 1:6 ){\n",
    "    plot(as.numeric(colnames(tmp)),tmp[i,],main=paste('Approved Drugs in\\n',rownames(tmp)[i]),type='l',bty='n',xlab='Year',ylab='n_approved',col=i,lty=2,lwd=3,ylim=c(0,10))\n",
    "}"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "According to EMA public data, in the last 28 years companies pushed forward the development of new drugs that may be indicated for a broad number of diseases or developing drugs for different treatment areas were the approaches chosen by companies with most approved drugs.\n",
    "\n",
    "Nevertheless, it seems that a large number of companies are developing drugs targeting a broad spectrum of indications; they do not need to approve more drugs because they will receive a constant revenue flow since their market share penetration is deeper."
   ]
  }
 ],
 "metadata": {
  "kernelspec": {
   "display_name": "R",
   "language": "R",
   "name": "ir"
  },
  "language_info": {
   "codemirror_mode": "r",
   "file_extension": ".r",
   "mimetype": "text/x-r-source",
   "name": "R",
   "pygments_lexer": "r",
   "version": "3.6.1"
  }
 },
 "nbformat": 4,
 "nbformat_minor": 4
}