diff --git a/submission.yaml b/submission.yaml
index 22f1fd8fa..c70ed0f08 100644
--- a/submission.yaml
+++ b/submission.yaml
@@ -1924,179 +1924,6 @@
   reference:
     - https://en.wikipedia.org/wiki/Luseogliflozin
     - https://en.wikipedia.org/wiki/SGLT2_inhibitor
-- directed: true
-  graph:
-    _id: DB01137_MESH_D018410_1
-    disease: Bacterial pneumonia
-    disease_mesh: MESH:D018410
-    drug: levofloxacin
-    drug_mesh: MESH:D064704
-    drugbank: DB:DB01137
-  links:
-    - key: negatively regulates
-      source: MESH:D064704
-      target: InterPro:IPR035516
-    - key: negatively regulates
-      source: MESH:D064704
-      target: InterPro:IPR013760
-    - key: positively regulates
-      source: InterPro:IPR035516
-      target: GO:0006260
-    - key: positively regulates
-      source: InterPro:IPR013760
-      target: GO:0006260
-    - key: in taxon
-      source: GO:0006260
-      target: NCBITaxon:1392
-    - key: causes
-      source: NCBITaxon:1392
-      target: MESH:D018410
-  multigraph: true
-  nodes:
-    - id: MESH:D064704
-      label: Drug
-      name: levofloxacin
-    - id: InterPro:IPR035516
-      label: GeneFamily
-      name: DNA gyrase/topoisomerase IV, subunit A, C-terminal
-    - id: InterPro:IPR013760
-      label: GeneFamily
-      name: DNA topoisomerase, type IIA-like domain superfamily
-    - id: GO:0006260
-      label: BiologicalProcess
-      name: Bacterial DNA replication
-    - id: NCBITaxon:1392
-      label: OrganismTaxon
-      name: Bacillus anthracis
-    - id: MESH:D018410
-      label: Disease
-      name: Bacterial pneumonia
-  reference:
-    - https://go.drugbank.com/drugs/DB01137#mechanism-of-action
-    - https://en.wikipedia.org/wiki/Bacterial_pneumonia#Types
-    - https://en.wikipedia.org/wiki/Levofloxacin#Mechanism_of_action
-  comment: Different bacterial species can cause pneumonia, the most frequent ones are Streptococcus pneumoniae, Staphylococcus aureus, and Bacillus anthracis, among the gram-positive types of bacteria. Gram-negative examples of bacteria causing pneumonia are Haemophilus influenzae, Klebsiella pneumoniae and Escherichia coli.
-- directed: true
-  graph:
-    _id: DB01137_MESH_D011023_1
-    disease: Staphylococcal pneumonia
-    disease_mesh: MESH:D011023
-    drug: levofloxacin
-    drug_mesh: MESH:D064704
-    drugbank: DB:DB01137
-  links:
-    - key: negatively regulates
-      source: MESH:D064704
-      target: InterPro:IPR035516
-    - key: negatively regulates
-      source: MESH:D064704
-      target: InterPro:IPR013760
-    - key: positively regulates
-      source: InterPro:IPR035516
-      target: GO:0006260
-    - key: positively regulates
-      source: InterPro:IPR013760
-      target: GO:0006260
-    - key: in taxon
-      source: GO:0006260
-      target: NCBITaxon:1280
-    - key: causes
-      source: NCBITaxon:1280
-      target: MESH:D011023
-  multigraph: true
-  nodes:
-    - id: MESH:D064704
-      label: Drug
-      name: levofloxacin
-    - id: InterPro:IPR035516
-      label: GeneFamily
-      name: DNA gyrase/topoisomerase IV, subunit A, C-terminal
-    - id: InterPro:IPR013760
-      label: GeneFamily
-      name: DNA topoisomerase, type IIA-like domain superfamily
-    - id: GO:0006260
-      label: BiologicalProcess
-      name: Bacterial DNA replication
-    - id: NCBITaxon:1280
-      label: OrganismTaxon
-      name: Staphylococcus aureus
-    - id: MESH:D011023
-      label: Disease
-      name: Staphylococcal pneumonia
-  reference:
-    - https://go.drugbank.com/drugs/DB01137#mechanism-of-action
-    - https://en.wikipedia.org/wiki/Bacterial_pneumonia#Gram-positive
-    - https://en.wikipedia.org/wiki/Staphylococcus_aureus#Role_in_disease
-    - https://en.wikipedia.org/wiki/Levofloxacin#Mechanism_of_action
-  comment: Different bacterial species can cause pneumonia, the most frequent ones are Streptococcus pneumoniae, Staphylococcus aureus, and Bacillus anthracis, among the gram-positive types of bacteria. Gram-negative examples of bacteria causing pneumonia are Haemophilus influenzae, Klebsiella pneumoniae and Escherichia coli.
-- directed: true
-  graph:
-    _id: DB01369_MESH_D013290_1
-    disease: Streptococcus pyogenes infection
-    disease_mesh: MESH:D013290
-    drug: quinupristin
-    drug_mesh: MESH:C113825
-    drugbank: DB:DB01369
-  links:
-    - key: decreases activity of
-      source: MESH:C113825
-      target: MESH:D054681
-    - key: negatively regulates
-      source: MESH:C113825
-      target: Pfam:PF00466
-    - key: negatively regulates
-      source: MESH:C113825
-      target: Pfam:PF00237
-    - key: positively regulates
-      source: Pfam:PF00466
-      target: GO:0006412
-    - key: positively regulates
-      source: Pfam:PF00237
-      target: GO:0006412
-    - key: location of
-      source: MESH:D054681
-      target: GO:0000048
-    - key: positively correlated with
-      source: GO:0000048
-      target: GO:0006412
-    - key: in taxon
-      source: GO:0006412
-      target: NCBITaxon:1314
-    - key: causes
-      source: NCBITaxon:1314
-      target: MESH:D013290
-  multigraph: true
-  nodes:
-    - id: MESH:C113825
-      label: Drug
-      name: quinupristin
-    - id: MESH:D054681
-      label: ChemicalSubstance
-      name: Ribosome Subunits, Large, Bacterial
-    - id: GO:0006412
-      label: BiologicalProcess
-      name: translation
-    - id: GO:0000048
-      label: MolecularActivity
-      name: peptidyltransferase activity
-    - id: Pfam:PF00237
-      label: GeneFamily
-      name: Ribosomal protein L22p/L17e
-    - id: Pfam:PF00466
-      label: GeneFamily
-      name: Ribosomal protein L10
-    - id: NCBITaxon:1314
-      label: OrganismTaxon
-      name: Streptococcus pyogenes
-    - id: MESH:D013290
-      label: Disease
-      name: Streptococcus pyogenes infection
-  reference:
-    - https://go.drugbank.com/drugs/DB01369#mechanism-of-action
-    - https://en.wikipedia.org/wiki/Quinupristin
-    - https://www.tandfonline.com/doi/abs/10.1517/13543784.7.4.591
-    - https://en.wikipedia.org/wiki/Quinupristin/dalfopristin#Mechanism_of_action
-  comment: This drug is used in combination with dalfopristin. Both interfere with the bacterial protein synthesis, at different stages of the translation. Quinupristin inhibits the late phase of protein synthesis, whereas dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome. In combination, both drugs are more effective than each used individually (https://go.drugbank.com/drugs/DB01369#description).
 - directed: true
   graph:
     _id: DB00461_MESH_D001172_1