From aaf222ac785e3a327f3a71bd95d112619c571baf Mon Sep 17 00:00:00 2001 From: TanskaAnnna Date: Sun, 23 May 2021 11:29:35 +0000 Subject: [PATCH] Commit from GitHub Actions (Update Indications on Merge) --- indication_paths.json | 2082 +++++++++++++++++++++++++++++++++++++++++ indication_paths.yaml | 1289 +++++++++++++++++++++++++ submission.yaml | 1269 +------------------------ 3 files changed, 3372 insertions(+), 1268 deletions(-) diff --git a/indication_paths.json b/indication_paths.json index 040d5a68d..4e8cef0cf 100644 --- a/indication_paths.json +++ b/indication_paths.json @@ -195516,5 +195516,2087 @@ "reference": [ "https://go.drugbank.com/drugs/DB09245" ] + }, + { + "directed": true, + "graph": { + "_id": "DB00090_MESH_D008059_2", + "disease": "Mucopolysaccharidosis, MPS-I", + "disease_mesh": "MESH:D008059", + "drug": "laronidase", + "drug_mesh": null, + "drugbank": "DB:DB00090" + }, + "links": [ + { + "key": "chemically similar to", + "source": "DB:DB00090", + "target": "UniProt:P35475" + }, + { + "key": "increases degradation of", + "source": "UniProt:P35475", + "target": "CHEBI:43394" + }, + { + "key": "decreases abundance of", + "source": "CHEBI:43394", + "target": "MESH:D006025" + }, + { + "key": "manifestation of", + "source": "MESH:D006025", + "target": "MESH:D008059" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "DB:DB00090", + "label": "Drug", + "name": "laronidase" + }, + { + "id": "UniProt:P35475", + "label": "Protein", + "name": "Alpha-L-iduronidase" + }, + { + "id": "CHEBI:43394", + "label": "ChemicalSubstance", + "name": "\u03b1-L-iduronic acid" + }, + { + "id": "MESH:D006025", + "label": "ChemicalSubstance", + "name": "Glycosaminoglycan" + }, + { + "id": "MESH:D008059", + "label": "Disease", + "name": "Mucopolysaccharidosis, MPS-I" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB00090" + ] + }, + { + "comment": "Mechanism of action unknown. 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"UniProt:P08069" + }, + { + "key": "participates in", + "source": "UniProt:P08069", + "target": "GO:0035988" + }, + { + "key": "participates in", + "source": "UniProt:P08069", + "target": "GO:0003423" + }, + { + "key": "participates in", + "source": "UniProt:P08069", + "target": "GO:0046622" + }, + { + "key": "negatively correlated with", + "source": "GO:0035988", + "target": "HP:0003510" + }, + { + "key": "negatively correlated with", + "source": "GO:0003423", + "target": "HP:0003510" + }, + { + "key": "negatively correlated with", + "source": "GO:0046622", + "target": "HP:0003510" + }, + { + "key": "correlated with", + "source": "HP:0003510", + "target": "MESH:D046150" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:C000604197", + "label": "Drug", + "name": "mecasermin" + }, + { + "id": "UniProt:P05019", + "label": "Protein", + "name": "Insulin-like growth factor I" + }, + { + "id": "UniProt:P08069", + "label": "Protein", + "name": "Insulin-like growth factor 1 receptor" + }, + { + "id": "GO:0035988", + "label": "BiologicalProcess", + "name": "chondrocyte proliferation" + }, + { + "id": "GO:0003423", + "label": "BiologicalProcess", + "name": "growth plate cartilage chondrocyte division" + }, + { + "id": "GO:0046622", + "label": "BiologicalProcess", + "name": "positive regulation of organ growth" + }, + { + "id": "HP:0003510", + "label": "PhenotypicFeature", + "name": "Severe short stature" + }, + { + "id": "MESH:D046150", + "label": "Disease", + "name": "Laron-type isolated somatotropin defect" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB01277", + "https://pubmed.ncbi.nlm.nih.gov/19198769/" + ] } ] \ No newline at end of file diff --git a/indication_paths.yaml b/indication_paths.yaml index f8abfd828..0461cd144 100644 --- a/indication_paths.yaml +++ b/indication_paths.yaml @@ -122909,3 +122909,1292 @@ name: Depressive disorder reference: - https://go.drugbank.com/drugs/DB09245 +- directed: true + graph: + _id: DB00090_MESH_D008059_2 + disease: Mucopolysaccharidosis, MPS-I + disease_mesh: MESH:D008059 + drug: laronidase + drug_mesh: null + drugbank: DB:DB00090 + links: + - key: chemically similar to + source: DB:DB00090 + target: UniProt:P35475 + - key: increases degradation of + source: UniProt:P35475 + target: CHEBI:43394 + - key: decreases abundance of + source: CHEBI:43394 + target: MESH:D006025 + - key: manifestation of + source: MESH:D006025 + target: MESH:D008059 + multigraph: true + nodes: + - id: DB:DB00090 + label: Drug + name: laronidase + - id: UniProt:P35475 + label: Protein + name: Alpha-L-iduronidase + - id: CHEBI:43394 + label: ChemicalSubstance + name: "\u03B1-L-iduronic acid" + - id: MESH:D006025 + label: ChemicalSubstance + name: Glycosaminoglycan + - id: MESH:D008059 + label: Disease + name: Mucopolysaccharidosis, MPS-I + reference: + - https://go.drugbank.com/drugs/DB00090 +- comment: Mechanism of action unknown. The hypothesis for the natural concentration + is that lutein helps protect from oxidative stress + directed: true + graph: + _id: DB00137_MESH_D008268_2 + disease: Age related macular degeneration + disease_mesh: MESH:D008268 + drug: lutein + drug_mesh: MESH:D014975 + drugbank: DB:DB00137 + links: + - key: chemically similar to + source: MESH:D014975 + target: CHEBI:23044 + - key: located in + source: CHEBI:23044 + target: UBERON:0000054 + - key: participates in + source: UBERON:0000054 + target: GO:0016209 + - key: prevents + source: GO:0016209 + target: MESH:D008268 + multigraph: true + nodes: + - id: MESH:D014975 + label: Drug + name: lutein + - id: CHEBI:23044 + label: ChemicalSubstance + name: carotenoid + - id: UBERON:0000054 + label: GrossAnatomicalStructure + name: Macula + - id: GO:0016209 + label: MolecularActivity + name: antioxidant activity + - id: MESH:D008268 + label: Disease + name: Age related macular degeneration + reference: + - https://go.drugbank.com/drugs/DB00137 + - https://pubmed.ncbi.nlm.nih.gov/28425969/ +- comment: Mechanism of action unknown. The hypothesis for the natural concentration + is that lutein helps protect from oxidative stress + directed: true + graph: + _id: DB00137_MESH_D015352_2 + disease: Tear film insufficiency + disease_mesh: MESH:D015352 + drug: lutein + drug_mesh: MESH:D014975 + drugbank: DB:DB00137 + links: + - key: chemically similar to + source: MESH:D014975 + target: CHEBI:23044 + - key: located in + source: CHEBI:23044 + target: UBERON:0000054 + - key: participates in + source: UBERON:0000054 + target: GO:0016209 + - key: prevents + source: GO:0016209 + target: MESH:D015352 + multigraph: true + nodes: + - id: MESH:D014975 + label: Drug + name: lutein + - id: CHEBI:23044 + label: ChemicalSubstance + name: carotenoid + - id: UBERON:0000054 + label: GrossAnatomicalStructure + name: Macula + - id: GO:0016209 + label: MolecularActivity + name: antioxidant activity + - id: MESH:D015352 + label: Disease + name: Tear film insufficiency + reference: + - https://go.drugbank.com/drugs/DB00137 + - https://pubmed.ncbi.nlm.nih.gov/28425969/ +- comment: Mechanism of action unknown. The hypothesis for the natural concentration + is that lutein helps protect from oxidative stress + directed: true + graph: + _id: DB00137_MESH_D000080343_2 + disease: Meibomian gland dysfunction + disease_mesh: MESH:D000080343 + drug: lutein + drug_mesh: MESH:D014975 + drugbank: DB:DB00137 + links: + - key: chemically similar to + source: MESH:D014975 + target: CHEBI:23044 + - key: located in + source: CHEBI:23044 + target: UBERON:0000054 + - key: participates in + source: UBERON:0000054 + target: GO:0016209 + - key: prevents + source: GO:0016209 + target: MESH:D000080343 + multigraph: true + nodes: + - id: MESH:D014975 + label: Drug + name: lutein + - id: CHEBI:23044 + label: ChemicalSubstance + name: carotenoid + - id: UBERON:0000054 + label: GrossAnatomicalStructure + name: Macula + - id: GO:0016209 + label: MolecularActivity + name: antioxidant activity + - id: MESH:D000080343 + label: Disease + name: Meibomian gland dysfunction + reference: + - https://go.drugbank.com/drugs/DB00137 + - https://pubmed.ncbi.nlm.nih.gov/28425969/ +- directed: true + graph: + _id: DB00209_MESH_D053202_2 + disease: Urge incontinence of urine + disease_mesh: MESH:D053202 + drug: trospium + drug_mesh: MESH:C003330 + drugbank: DB:DB00209 + links: + - key: decreases activity of + source: MESH:C003330 + target: UniProt:P20309 + - key: participates in + source: UniProt:P20309 + target: GO:1905144 + - key: positively regulates + source: GO:1905144 + target: GO:0014832 + - key: located in + source: GO:0014832 + target: UBERON:0001255 + - key: correlated with + source: UBERON:0001255 + target: GO:0060073 + - key: correlated with + source: GO:0060073 + target: MESH:D053202 + multigraph: true + nodes: + - id: MESH:C003330 + label: Drug + name: trospium + - id: UniProt:P20309 + label: Protein + name: Muscarinic acetylcholine receptor M3 + - id: GO:1905144 + label: BiologicalProcess + name: response to acetylcholine + - id: GO:0014832 + label: BiologicalProcess + name: Urinary bladder smooth muscle contraction + - id: UBERON:0001255 + label: GrossAnatomicalStructure + name: urinary bladder + - id: GO:0014832 + label: BiologicalProcess + name: Urinary bladder smooth muscle contraction + - id: GO:0060073 + label: BiologicalProcess + name: micturition + - id: MESH:D053202 + label: Disease + name: Urge incontinence of urine + reference: + - https://go.drugbank.com/drugs/DB00209#BE0000045 + - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906583/ +- directed: true + graph: + _id: DB00570_MESH_D012514_2 + disease: Kaposi's sarcoma + disease_mesh: MESH:D012514 + drug: vinblastine + drug_mesh: MESH:D014747 + drugbank: DB:DB00570 + links: + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q71U36 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:P07437 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q9UJT1 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:P23258 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q9UJT0 + - key: part of + source: UniProt:Q71U36 + target: GO:1902850 + - key: part of + source: UniProt:Q71U36 + target: GO:1902850 + - key: part of + source: UniProt:P07437 + target: GO:1902850 + - key: part of + source: UniProt:Q9UJT1 + target: GO:1902850 + - key: part of + source: UniProt:P23258 + target: GO:1902850 + - key: part of + source: UniProt:Q9UJT0 + target: GO:1902850 + - key: positively regulates + source: GO:1902850 + target: GO:0140014 + - key: positively regulates + source: GO:0140014 + target: GO:0008283 + - key: positively correlated with + source: GO:0008283 + target: MESH:D012514 + multigraph: true + nodes: + - id: MESH:D014747 + label: Drug + name: vinblastine + - id: UniProt:Q71U36 + label: Protein + name: Tubulin alpha-1A chain + - id: UniProt:P07437 + label: Protein + name: Tubulin beta chain + - id: UniProt:Q9UJT1 + label: Protein + name: Tubulin delta chain + - id: UniProt:P23258 + label: Protein + name: Tubulin gamma-1 chain + - id: UniProt:Q9UJT0 + label: Protein + name: Tubulin epsilon chain + - id: GO:1902850 + label: BiologicalProcess + name: Microtubule cytoskeleton organization involved in mitosis + - id: GO:0140014 + label: BiologicalProcess + name: Mitotic nuclear division + - id: GO:0008283 + label: BiologicalProcess + name: Cell population proliferation + - id: MESH:D012514 + label: Disease + name: Kaposi's sarcoma + reference: + - https://go.drugbank.com/drugs/DB00570#BE0001340 + - https://en.wikipedia.org/wiki/Vinblastine +- directed: true + graph: + _id: DB00570_MESH_D009182_2 + disease: Mycosis fungoides + disease_mesh: MESH:D009182 + drug: vinblastine + drug_mesh: MESH:D014747 + drugbank: DB:DB00570 + links: + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q71U36 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:P07437 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q9UJT1 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:P23258 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q9UJT0 + - key: part of + source: UniProt:Q71U36 + target: GO:1902850 + - key: part of + source: UniProt:Q71U36 + target: GO:1902850 + - key: part of + source: UniProt:P07437 + target: GO:1902850 + - key: part of + source: UniProt:Q9UJT1 + target: GO:1902850 + - key: part of + source: UniProt:P23258 + target: GO:1902850 + - key: part of + source: UniProt:Q9UJT0 + target: GO:1902850 + - key: positively regulates + source: GO:1902850 + target: GO:0140014 + - key: positively regulates + source: GO:0140014 + target: GO:0008283 + - key: positively correlated with + source: GO:0008283 + target: MESH:D009182 + multigraph: true + nodes: + - id: MESH:D014747 + label: Drug + name: vinblastine + - id: UniProt:Q71U36 + label: Protein + name: Tubulin alpha-1A chain + - id: UniProt:P07437 + label: Protein + name: Tubulin beta chain + - id: UniProt:Q9UJT1 + label: Protein + name: Tubulin delta chain + - id: UniProt:P23258 + label: Protein + name: Tubulin gamma-1 chain + - id: UniProt:Q9UJT0 + label: Protein + name: Tubulin epsilon chain + - id: GO:1902850 + label: BiologicalProcess + name: Microtubule cytoskeleton organization involved in mitosis + - id: GO:0140014 + label: BiologicalProcess + name: Mitotic nuclear division + - id: GO:0008283 + label: BiologicalProcess + name: Cell population proliferation + - id: MESH:D009182 + label: Disease + name: Mycosis fungoides + reference: + - https://go.drugbank.com/drugs/DB00570#BE0001340 + - https://en.wikipedia.org/wiki/Vinblastine +- directed: true + graph: + _id: DB00570_MESH_D008228_2 + disease: Non-Hodgkin's lymphoma + disease_mesh: MESH:D008228 + drug: vinblastine + drug_mesh: MESH:D014747 + drugbank: DB:DB00570 + links: + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q71U36 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:P07437 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q9UJT1 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:P23258 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q9UJT0 + - key: part of + source: UniProt:Q71U36 + target: GO:1902850 + - key: part of + source: UniProt:Q71U36 + target: GO:1902850 + - key: part of + source: UniProt:P07437 + target: GO:1902850 + - key: part of + source: UniProt:Q9UJT1 + target: GO:1902850 + - key: part of + source: UniProt:P23258 + target: GO:1902850 + - key: part of + source: UniProt:Q9UJT0 + target: GO:1902850 + - key: positively regulates + source: GO:1902850 + target: GO:0140014 + - key: positively regulates + source: GO:0140014 + target: GO:0008283 + - key: positively correlated with + source: GO:0008283 + target: MESH:D008228 + multigraph: true + nodes: + - id: MESH:D014747 + label: Drug + name: vinblastine + - id: UniProt:Q71U36 + label: Protein + name: Tubulin alpha-1A chain + - id: UniProt:P07437 + label: Protein + name: Tubulin beta chain + - id: UniProt:Q9UJT1 + label: Protein + name: Tubulin delta chain + - id: UniProt:P23258 + label: Protein + name: Tubulin gamma-1 chain + - id: UniProt:Q9UJT0 + label: Protein + name: Tubulin epsilon chain + - id: GO:1902850 + label: BiologicalProcess + name: Microtubule cytoskeleton organization involved in mitosis + - id: GO:0140014 + label: BiologicalProcess + name: Mitotic nuclear division + - id: GO:0008283 + label: BiologicalProcess + name: Cell population proliferation + - id: MESH:D008228 + label: Disease + name: Non-Hodgkin's lymphoma + reference: + - https://go.drugbank.com/drugs/DB00570#BE0001340 + - https://en.wikipedia.org/wiki/Vinblastine +- directed: true + graph: + _id: DB00570_MESH_D013736_2 + disease: Malignant tumor of testis + disease_mesh: MESH:D013736 + drug: vinblastine + drug_mesh: MESH:D014747 + drugbank: DB:DB00570 + links: + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q71U36 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:P07437 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q9UJT1 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:P23258 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q9UJT0 + - key: part of + source: UniProt:Q71U36 + target: GO:1902850 + - key: part of + source: UniProt:Q71U36 + target: GO:1902850 + - key: part of + source: UniProt:P07437 + target: GO:1902850 + - key: part of + source: UniProt:Q9UJT1 + target: GO:1902850 + - key: part of + source: UniProt:P23258 + target: GO:1902850 + - key: part of + source: UniProt:Q9UJT0 + target: GO:1902850 + - key: positively regulates + source: GO:1902850 + target: GO:0140014 + - key: positively regulates + source: GO:0140014 + target: GO:0008283 + - key: positively correlated with + source: GO:0008283 + target: MESH:D013736 + multigraph: true + nodes: + - id: MESH:D014747 + label: Drug + name: vinblastine + - id: UniProt:Q71U36 + label: Protein + name: Tubulin alpha-1A chain + - id: UniProt:P07437 + label: Protein + name: Tubulin beta chain + - id: UniProt:Q9UJT1 + label: Protein + name: Tubulin delta chain + - id: UniProt:P23258 + label: Protein + name: Tubulin gamma-1 chain + - id: UniProt:Q9UJT0 + label: Protein + name: Tubulin epsilon chain + - id: GO:1902850 + label: BiologicalProcess + name: Microtubule cytoskeleton organization involved in mitosis + - id: GO:0140014 + label: BiologicalProcess + name: Mitotic nuclear division + - id: GO:0008283 + label: BiologicalProcess + name: Cell population proliferation + - id: MESH:D013736 + label: Disease + name: Malignant tumor of testis + reference: + - https://go.drugbank.com/drugs/DB00570#BE0001340 + - https://en.wikipedia.org/wiki/Vinblastine +- directed: true + graph: + _id: DB00570_MESH_C538636_2 + disease: Langerhans cell histiocytosis, disseminated + disease_mesh: MESH:C538636 + drug: vinblastine + drug_mesh: MESH:D014747 + drugbank: DB:DB00570 + links: + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q71U36 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:P07437 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q9UJT1 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:P23258 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q9UJT0 + - key: part of + source: UniProt:Q71U36 + target: GO:1902850 + - key: part of + source: UniProt:Q71U36 + target: GO:1902850 + - key: part of + source: UniProt:P07437 + target: GO:1902850 + - key: part of + source: UniProt:Q9UJT1 + target: GO:1902850 + - key: part of + source: UniProt:P23258 + target: GO:1902850 + - key: part of + source: UniProt:Q9UJT0 + target: GO:1902850 + - key: positively regulates + source: GO:1902850 + target: GO:0140014 + - key: positively regulates + source: GO:0140014 + target: GO:0008283 + - key: positively correlated with + source: GO:0008283 + target: MESH:C538636 + multigraph: true + nodes: + - id: MESH:D014747 + label: Drug + name: vinblastine + - id: UniProt:Q71U36 + label: Protein + name: Tubulin alpha-1A chain + - id: UniProt:P07437 + label: Protein + name: Tubulin beta chain + - id: UniProt:Q9UJT1 + label: Protein + name: Tubulin delta chain + - id: UniProt:P23258 + label: Protein + name: Tubulin gamma-1 chain + - id: UniProt:Q9UJT0 + label: Protein + name: Tubulin epsilon chain + - id: GO:1902850 + label: BiologicalProcess + name: Microtubule cytoskeleton organization involved in mitosis + - id: GO:0140014 + label: BiologicalProcess + name: Mitotic nuclear division + - id: GO:0008283 + label: BiologicalProcess + name: Cell population proliferation + - id: MESH:C538636 + label: Disease + name: Langerhans cell histiocytosis, disseminated + reference: + - https://go.drugbank.com/drugs/DB00570#BE0001340 + - https://en.wikipedia.org/wiki/Vinblastine +- directed: true + graph: + _id: DB00570_MESH_D006689_2 + disease: Hodgkin's disease + disease_mesh: MESH:D006689 + drug: vinblastine + drug_mesh: MESH:D014747 + drugbank: DB:DB00570 + links: + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q71U36 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:P07437 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q9UJT1 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:P23258 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q9UJT0 + - key: part of + source: UniProt:Q71U36 + target: GO:1902850 + - key: part of + source: UniProt:Q71U36 + target: GO:1902850 + - key: part of + source: UniProt:P07437 + target: GO:1902850 + - key: part of + source: UniProt:Q9UJT1 + target: GO:1902850 + - key: part of + source: UniProt:P23258 + target: GO:1902850 + - key: part of + source: UniProt:Q9UJT0 + target: GO:1902850 + - key: positively regulates + source: GO:1902850 + target: GO:0140014 + - key: positively regulates + source: GO:0140014 + target: GO:0008283 + - key: positively correlated with + source: GO:0008283 + target: MESH:D006689 + multigraph: true + nodes: + - id: MESH:D014747 + label: Drug + name: vinblastine + - id: UniProt:Q71U36 + label: Protein + name: Tubulin alpha-1A chain + - id: UniProt:P07437 + label: Protein + name: Tubulin beta chain + - id: UniProt:Q9UJT1 + label: Protein + name: Tubulin delta chain + - id: UniProt:P23258 + label: Protein + name: Tubulin gamma-1 chain + - id: UniProt:Q9UJT0 + label: Protein + name: Tubulin epsilon chain + - id: GO:1902850 + label: BiologicalProcess + name: Microtubule cytoskeleton organization involved in mitosis + - id: GO:0140014 + label: BiologicalProcess + name: Mitotic nuclear division + - id: GO:0008283 + label: BiologicalProcess + name: Cell population proliferation + - id: MESH:D006689 + label: Disease + name: Hodgkin's disease + reference: + - https://go.drugbank.com/drugs/DB00570#BE0001340 + - https://en.wikipedia.org/wiki/Vinblastine +- directed: true + graph: + _id: DB00570_MESH_D031901_2 + disease: Gestational trophoblastic neoplasia + disease_mesh: MESH:D031901 + drug: vinblastine + drug_mesh: MESH:D014747 + drugbank: DB:DB00570 + links: + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q71U36 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:P07437 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q9UJT1 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:P23258 + - key: decreases activity of + source: MESH:D014747 + target: UniProt:Q9UJT0 + - key: part of + source: UniProt:Q71U36 + target: GO:1902850 + - key: part of + source: UniProt:Q71U36 + target: GO:1902850 + - key: part of + source: UniProt:P07437 + target: GO:1902850 + - key: part of + source: UniProt:Q9UJT1 + target: GO:1902850 + - key: part of + source: UniProt:P23258 + target: GO:1902850 + - key: part of + source: UniProt:Q9UJT0 + target: GO:1902850 + - key: positively regulates + source: GO:1902850 + target: GO:0140014 + - key: positively regulates + source: GO:0140014 + target: GO:0008283 + - key: positively correlated with + source: GO:0008283 + target: MESH:D031901 + multigraph: true + nodes: + - id: MESH:D014747 + label: Drug + name: vinblastine + - id: UniProt:Q71U36 + label: Protein + name: Tubulin alpha-1A chain + - id: UniProt:P07437 + label: Protein + name: Tubulin beta chain + - id: UniProt:Q9UJT1 + label: Protein + name: Tubulin delta chain + - id: UniProt:P23258 + label: Protein + name: Tubulin gamma-1 chain + - id: UniProt:Q9UJT0 + label: Protein + name: Tubulin epsilon chain + - id: GO:1902850 + label: BiologicalProcess + name: Microtubule cytoskeleton organization involved in mitosis + - id: GO:0140014 + label: BiologicalProcess + name: Mitotic nuclear division + - id: GO:0008283 + label: BiologicalProcess + name: Cell population proliferation + - id: MESH:D031901 + label: Disease + name: Gestational trophoblastic neoplasia + reference: + - https://go.drugbank.com/drugs/DB00570#BE0001340 + - https://en.wikipedia.org/wiki/Vinblastine +- comment: Mechanism of action of penicillamine wrt to Rheumatoid arthritis is unknown + directed: true + graph: + _id: DB00859_MESH_D001172_2 + disease: Rheumatoid arthritis + disease_mesh: MESH:D001172 + drug: penicillamine + drug_mesh: MESH:D010396 + drugbank: DB:DB00859 + links: + - key: capable of + source: MESH:D010396 + target: GO:0046911 + - key: decreases activity of + source: GO:0046911 + target: CL:0000084 + - key: participates in + source: CL:0000084 + target: GO:0006955 + - key: positively correlated with + source: GO:0006955 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D001172 + multigraph: true + nodes: + - id: MESH:D010396 + label: Drug + name: penicillamine + - id: GO:0046911 + label: MolecularActivity + name: metal chelating activity + - id: CL:0000084 + label: Cell + name: T cell + - id: GO:0006955 + label: BiologicalProcess + name: Immune response + - id: GO:0006954 + label: BiologicalProcess + name: Inflammation + - id: MESH:D001172 + label: Disease + name: Rheumatoid arthritis + reference: + - https://go.drugbank.com/drugs/DB00859 + - https://www.sciencedirect.com/science/article/pii/B9780080280240500165 +- directed: true + graph: + _id: DB00859_MESH_D006527_2 + disease: Wilson's disease + disease_mesh: MESH:D006527 + drug: penicillamine + drug_mesh: MESH:D010396 + drugbank: DB:DB00859 + links: + - key: capable of + source: MESH:D010396 + target: GO:0046911 + - key: decreases abundance of + source: GO:0046911 + target: MESH:D003300 + - key: regulates + source: MESH:D003300 + target: GO:0055070 + - key: treats + source: GO:0055070 + target: MESH:D006527 + multigraph: true + nodes: + - id: MESH:D010396 + label: Drug + name: penicillamine + - id: GO:0046911 + label: MolecularActivity + name: metal chelating activity + - id: MESH:D003300 + label: ChemicalSubstance + name: Copper + - id: GO:0055070 + label: BiologicalProcess + name: Copper ion homeostasis + - id: MESH:D006527 + label: Disease + name: Wilson's disease + reference: + - https://go.drugbank.com/drugs/DB00859 + - https://pubmed.ncbi.nlm.nih.gov/22802922/ +- directed: true + graph: + _id: DB00859_MESH_D003555_2 + disease: Cystinuria + disease_mesh: MESH:D003555 + drug: penicillamine + drug_mesh: MESH:D010396 + drugbank: DB:DB00859 + links: + - key: capable of + source: MESH:D010396 + target: GO:0046911 + - key: decreases abundance of + source: GO:0046911 + target: CHEBI:17376 + - key: causes + source: CHEBI:17376 + target: HP:0003131 + - key: manifestation of + source: HP:0003131 + target: MESH:D003555 + multigraph: true + nodes: + - id: MESH:D010396 + label: Drug + name: penicillamine + - id: GO:0046911 + label: MolecularActivity + name: metal chelating activity + - id: CHEBI:17376 + label: ChemicalSubstance + name: cystine + - id: HP:0003131 + label: PhenotypicFeature + name: Cystinuria + - id: MESH:D003555 + label: Disease + name: Cystinuria + reference: + - https://go.drugbank.com/drugs/DB00859 +- directed: true + graph: + _id: DB01268_MESH_D046152_2 + disease: Gastrointestinal stromal tumor + disease_mesh: MESH:D046152 + drug: sunitinib + drug_mesh: MESH:C473478 + drugbank: DB:DB01268 + links: + - key: decreases activity of + source: MESH:C473478 + target: UniProt:P09619 + - key: decreases activity of + source: MESH:C473478 + target: UniProt:P17948 + - key: decreases activity of + source: MESH:C473478 + target: UniProt:P10721 + - key: decreases activity of + source: MESH:C473478 + target: UniProt:P35968 + - key: decreases activity of + source: MESH:C473478 + target: UniProt:P35916 + - key: decreases activity of + source: MESH:C473478 + target: UniProt:P36888 + - key: decreases activity of + source: MESH:C473478 + target: UniProt:P07333 + - key: decreases activity of + source: MESH:C473478 + target: UniProt:P16234 + - key: positively regulates + source: UniProt:P09619 + target: GO:0008284 + - key: positively regulates + source: UniProt:P17948 + target: GO:0008284 + - key: positively regulates + source: UniProt:P10721 + target: GO:0008284 + - key: positively regulates + source: UniProt:P35968 + target: GO:0008284 + - key: positively regulates + source: UniProt:P35916 + target: GO:0008284 + - key: positively regulates + source: UniProt:P36888 + target: GO:0008284 + - key: positively regulates + source: UniProt:P07333 + target: GO:0008284 + - key: positively regulates + source: UniProt:P16234 + target: GO:0008284 + - key: positively regulates + source: UniProt:P09619 + target: GO:0045766 + - key: positively regulates + source: UniProt:P17948 + target: GO:0045766 + - key: positively regulates + source: UniProt:P10721 + target: GO:0045766 + - key: positively regulates + source: UniProt:P35968 + target: GO:0045766 + - key: positively regulates + source: UniProt:P35916 + target: GO:0045766 + - key: positively regulates + source: UniProt:P36888 + target: GO:0045766 + - key: positively regulates + source: UniProt:P07333 + target: GO:0045766 + - key: positively regulates + source: UniProt:P16234 + target: GO:0045766 + - key: located in + source: GO:0045766 + target: CL:0001064 + - key: located in + source: GO:0008284 + target: CL:0001064 + - key: participates in + source: CL:0001064 + target: MESH:D046152 + multigraph: true + nodes: + - id: MESH:C473478 + label: Drug + name: sunitinib + - id: UniProt:P09619 + label: Protein + name: Platelet-derived growth factor receptor beta + - id: UniProt:P17948 + label: Protein + name: Vascular endothelial growth factor receptor 1 + - id: UniProt:P10721 + label: Protein + name: Mast/stem cell growth factor receptor Kit + - id: UniProt:P35968 + label: Protein + name: Vascular endothelial growth factor receptor 2 + - id: UniProt:P35916 + label: Protein + name: Vascular endothelial growth factor receptor 3 + - id: UniProt:P36888 + label: Protein + name: Receptor-type tyrosine-protein kinase FLT3 + - id: UniProt:P07333 + label: Protein + name: Macrophage colony-stimulating factor 1 receptor + - id: UniProt:P16234 + label: Protein + name: Platelet-derived growth factor receptor alpha + - id: GO:0008284 + label: BiologicalProcess + name: positive regulation of cell population proliferation + - id: GO:0045766 + label: BiologicalProcess + name: positive regulation of angiogenesis + - id: CL:0001064 + label: Cell + name: cancer cell + - id: MESH:D046152 + label: Disease + name: Gastrointestinal stromal tumor + reference: + - https://go.drugbank.com/drugs/DB01268 + - https://pubmed.ncbi.nlm.nih.gov/20110785/ +- directed: true + graph: + _id: DB01268_MESH_D002292_2 + disease: Renal cell carcinoma + disease_mesh: MESH:D002292 + drug: sunitinib + drug_mesh: MESH:C473478 + drugbank: DB:DB01268 + links: + - key: decreases activity of + source: MESH:C473478 + target: UniProt:P09619 + - key: decreases activity of + source: MESH:C473478 + target: UniProt:P17948 + - key: decreases activity of + source: MESH:C473478 + target: UniProt:P10721 + - key: decreases activity of + source: MESH:C473478 + target: UniProt:P35968 + - key: decreases activity of + source: MESH:C473478 + target: UniProt:P35916 + - key: decreases activity of + source: MESH:C473478 + target: UniProt:P36888 + - key: decreases activity of + source: MESH:C473478 + target: UniProt:P07333 + - key: decreases activity of + source: MESH:C473478 + target: UniProt:P16234 + - key: positively regulates + source: UniProt:P09619 + target: GO:0008284 + - key: positively regulates + source: UniProt:P17948 + target: GO:0008284 + - key: positively regulates + source: UniProt:P10721 + target: GO:0008284 + - key: positively regulates + source: UniProt:P35968 + target: GO:0008284 + - key: positively regulates + source: UniProt:P35916 + target: GO:0008284 + - key: positively regulates + source: UniProt:P36888 + target: GO:0008284 + - key: positively regulates + source: UniProt:P07333 + target: GO:0008284 + - key: positively regulates + source: UniProt:P16234 + target: GO:0008284 + - key: positively regulates + source: UniProt:P09619 + target: GO:0045766 + - key: positively regulates + source: UniProt:P17948 + target: GO:0045766 + - key: positively regulates + source: UniProt:P10721 + target: GO:0045766 + - key: positively regulates + source: UniProt:P35968 + target: GO:0045766 + - key: positively regulates + source: UniProt:P35916 + target: GO:0045766 + - key: positively regulates + source: UniProt:P36888 + target: GO:0045766 + - key: positively regulates + source: UniProt:P07333 + target: GO:0045766 + - key: positively regulates + source: UniProt:P16234 + target: GO:0045766 + - key: located in + source: GO:0045766 + target: CL:0001064 + - key: located in + source: GO:0008284 + target: CL:0001064 + - key: participates in + source: CL:0001064 + target: MESH:D002292 + multigraph: true + nodes: + - id: MESH:C473478 + label: Drug + name: sunitinib + - id: UniProt:P09619 + label: Protein + name: Platelet-derived growth factor receptor beta + - id: UniProt:P17948 + label: Protein + name: Vascular endothelial growth factor receptor 1 + - id: UniProt:P10721 + label: Protein + name: Mast/stem cell growth factor receptor Kit + - id: UniProt:P35968 + label: Protein + name: Vascular endothelial growth factor receptor 2 + - id: UniProt:P35916 + label: Protein + name: Vascular endothelial growth factor receptor 3 + - id: UniProt:P36888 + label: Protein + name: Receptor-type tyrosine-protein kinase FLT3 + - id: UniProt:P07333 + label: Protein + name: Macrophage colony-stimulating factor 1 receptor + - id: UniProt:P16234 + label: Protein + name: Platelet-derived growth factor receptor alpha + - id: GO:0008284 + label: BiologicalProcess + name: positive regulation of cell population proliferation + - id: GO:0045766 + label: BiologicalProcess + name: positive regulation of angiogenesis + - id: CL:0001064 + label: Cell + name: cancer cell + - id: MESH:D002292 + label: Disease + name: Renal cell carcinoma + reference: + - https://go.drugbank.com/drugs/DB01268 + - https://pubmed.ncbi.nlm.nih.gov/20110785/ +- directed: true + graph: + _id: DB01277_MESH_D046150_2 + disease: Laron-type isolated somatotropin defect + disease_mesh: MESH:D046150 + drug: mecasermin + drug_mesh: MESH:C000604197 + drugbank: DB:DB01277 + links: + - key: chemically similar to + source: MESH:C000604197 + target: UniProt:P05019 + - key: increases activity of + source: UniProt:P05019 + target: UniProt:P08069 + - key: participates in + source: UniProt:P08069 + target: GO:0035988 + - key: participates in + source: UniProt:P08069 + target: GO:0003423 + - key: participates in + source: UniProt:P08069 + target: GO:0046622 + - key: negatively correlated with + source: GO:0035988 + target: HP:0003510 + - key: negatively correlated with + source: GO:0003423 + target: HP:0003510 + - key: negatively correlated with + source: GO:0046622 + target: HP:0003510 + - key: correlated with + source: HP:0003510 + target: MESH:D046150 + multigraph: true + nodes: + - id: MESH:C000604197 + label: Drug + name: mecasermin + - id: UniProt:P05019 + label: Protein + name: Insulin-like growth factor I + - id: UniProt:P08069 + label: Protein + name: Insulin-like growth factor 1 receptor + - id: GO:0035988 + label: BiologicalProcess + name: chondrocyte proliferation + - id: GO:0003423 + label: BiologicalProcess + name: growth plate cartilage chondrocyte division + - id: GO:0046622 + label: BiologicalProcess + name: positive regulation of organ growth + - id: HP:0003510 + label: PhenotypicFeature + name: Severe short stature + - id: MESH:D046150 + label: Disease + name: Laron-type isolated somatotropin defect + reference: + - https://go.drugbank.com/drugs/DB01277 + - https://pubmed.ncbi.nlm.nih.gov/19198769/ diff --git a/submission.yaml b/submission.yaml index b3e65e3d0..8b1378917 100644 --- a/submission.yaml +++ b/submission.yaml @@ -1,1268 +1 @@ -- directed: true - graph: - disease: Mucopolysaccharidosis, MPS-I - disease_mesh: MESH:D008059 - drug: laronidase - drug_mesh: null - drugbank: DB:DB00090 - links: - - key: chemically similar to - source: DB:DB00090 - target: UniProt:P35475 - - key: increases degradation of - source: UniProt:P35475 - target: CHEBI:43394 - - key: decreases abundance of - source: CHEBI:43394 - target: MESH:D006025 - - key: manifestation of - source: MESH:D006025 - target: MESH:D008059 - multigraph: true - nodes: - - id: DB:DB00090 - label: Drug - name: laronidase - - id: UniProt:P35475 - label: Protein - name: Alpha-L-iduronidase - - id: CHEBI:43394 - label: ChemicalSubstance - name: α-L-iduronic acid - - id: MESH:D006025 - label: ChemicalSubstance - name: Glycosaminoglycan - - id: MESH:D008059 - label: Disease - name: Mucopolysaccharidosis, MPS-I - reference: - - https://go.drugbank.com/drugs/DB00090 -- comment: Mechanism of action unknown. The hypothesis for the natural concentration is that lutein helps protect from oxidative stress - directed: true - graph: - disease: Age related macular degeneration - disease_mesh: MESH:D008268 - drug: lutein - drug_mesh: MESH:D014975 - drugbank: DB:DB00137 - links: - - key: chemically similar to - source: MESH:D014975 - target: CHEBI:23044 - - key: located in - source: CHEBI:23044 - target: UBERON:0000054 - - key: participates in - source: UBERON:0000054 - target: GO:0016209 - - key: prevents - source: GO:0016209 - target: MESH:D008268 - multigraph: true - nodes: - - id: MESH:D014975 - label: Drug - name: lutein - - id: CHEBI:23044 - label: ChemicalSubstance - name: carotenoid - - id: UBERON:0000054 - label: GrossAnatomicalStructure - name: Macula - - id: GO:0016209 - label: MolecularActivity - name: antioxidant activity - - id: MESH:D008268 - label: Disease - name: Age related macular degeneration - reference: - - https://go.drugbank.com/drugs/DB00137 - - https://pubmed.ncbi.nlm.nih.gov/28425969/ -- comment: Mechanism of action unknown. The hypothesis for the natural concentration is that lutein helps protect from oxidative stress - directed: true - graph: - disease: Tear film insufficiency - disease_mesh: MESH:D015352 - drug: lutein - drug_mesh: MESH:D014975 - drugbank: DB:DB00137 - links: - - key: chemically similar to - source: MESH:D014975 - target: CHEBI:23044 - - key: located in - source: CHEBI:23044 - target: UBERON:0000054 - - key: participates in - source: UBERON:0000054 - target: GO:0016209 - - key: prevents - source: GO:0016209 - target: MESH:D015352 - multigraph: true - nodes: - - id: MESH:D014975 - label: Drug - name: lutein - - id: CHEBI:23044 - label: ChemicalSubstance - name: carotenoid - - id: UBERON:0000054 - label: GrossAnatomicalStructure - name: Macula - - id: GO:0016209 - label: MolecularActivity - name: antioxidant activity - - id: MESH:D015352 - label: Disease - name: Tear film insufficiency - reference: - - https://go.drugbank.com/drugs/DB00137 - - https://pubmed.ncbi.nlm.nih.gov/28425969/ -- comment: Mechanism of action unknown. The hypothesis for the natural concentration is that lutein helps protect from oxidative stress - directed: true - graph: - disease: Meibomian gland dysfunction - disease_mesh: MESH:D000080343 - drug: lutein - drug_mesh: MESH:D014975 - drugbank: DB:DB00137 - links: - - key: chemically similar to - source: MESH:D014975 - target: CHEBI:23044 - - key: located in - source: CHEBI:23044 - target: UBERON:0000054 - - key: participates in - source: UBERON:0000054 - target: GO:0016209 - - key: prevents - source: GO:0016209 - target: MESH:D000080343 - multigraph: true - nodes: - - id: MESH:D014975 - label: Drug - name: lutein - - id: CHEBI:23044 - label: ChemicalSubstance - name: carotenoid - - id: UBERON:0000054 - label: GrossAnatomicalStructure - name: Macula - - id: GO:0016209 - label: MolecularActivity - name: antioxidant activity - - id: MESH:D000080343 - label: Disease - name: Meibomian gland dysfunction - reference: - - https://go.drugbank.com/drugs/DB00137 - - https://pubmed.ncbi.nlm.nih.gov/28425969/ -- directed: true - graph: - disease: Urge incontinence of urine - disease_mesh: MESH:D053202 - drug: trospium - drug_mesh: MESH:C003330 - drugbank: DB:DB00209 - links: - - key: decreases activity of - source: MESH:C003330 - target: UniProt:P20309 - - key: participates in - source: UniProt:P20309 - target: GO:1905144 - - key: positively regulates - source: GO:1905144 - target: GO:0014832 - - key: located in - source: GO:0014832 - target: UBERON:0001255 - - key: correlated with - source: UBERON:0001255 - target: GO:0060073 - - key: correlated with - source: GO:0060073 - target: MESH:D053202 - multigraph: true - nodes: - - id: MESH:C003330 - label: Drug - name: trospium - - id: UniProt:P20309 - label: Protein - name: Muscarinic acetylcholine receptor M3 - - id: GO:1905144 - label: BiologicalProcess - name: response to acetylcholine - - id: GO:0014832 - label: BiologicalProcess - name: Urinary bladder smooth muscle contraction - - id: UBERON:0001255 - label: GrossAnatomicalStructure - name: urinary bladder - - id: GO:0014832 - label: BiologicalProcess - name: Urinary bladder smooth muscle contraction - - id: GO:0060073 - label: BiologicalProcess - name: micturition - - id: MESH:D053202 - label: Disease - name: Urge incontinence of urine - reference: - - https://go.drugbank.com/drugs/DB00209#BE0000045 - - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906583/ -- directed: true - graph: - disease: Kaposi's sarcoma - disease_mesh: MESH:D012514 - drug: vinblastine - drug_mesh: MESH:D014747 - drugbank: DB:DB00570 - links: - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q71U36 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:P07437 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q9UJT1 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:P23258 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q9UJT0 - - key: part of - source: UniProt:Q71U36 - target: GO:1902850 - - key: part of - source: UniProt:Q71U36 - target: GO:1902850 - - key: part of - source: UniProt:P07437 - target: GO:1902850 - - key: part of - source: UniProt:Q9UJT1 - target: GO:1902850 - - key: part of - source: UniProt:P23258 - target: GO:1902850 - - key: part of - source: UniProt:Q9UJT0 - target: GO:1902850 - - key: positively regulates - source: GO:1902850 - target: GO:0140014 - - key: positively regulates - source: GO:0140014 - target: GO:0008283 - - key: positively correlated with - source: GO:0008283 - target: MESH:D012514 - multigraph: true - nodes: - - id: MESH:D014747 - label: Drug - name: vinblastine - - id: UniProt:Q71U36 - label: Protein - name: Tubulin alpha-1A chain - - id: UniProt:P07437 - label: Protein - name: Tubulin beta chain - - id: UniProt:Q9UJT1 - label: Protein - name: Tubulin delta chain - - id: UniProt:P23258 - label: Protein - name: Tubulin gamma-1 chain - - id: UniProt:Q9UJT0 - label: Protein - name: Tubulin epsilon chain - - id: GO:1902850 - label: BiologicalProcess - name: Microtubule cytoskeleton organization involved in mitosis - - id: GO:0140014 - label: BiologicalProcess - name: Mitotic nuclear division - - id: GO:0008283 - label: BiologicalProcess - name: Cell population proliferation - - id: MESH:D012514 - label: Disease - name: Kaposi's sarcoma - reference: - - https://go.drugbank.com/drugs/DB00570#BE0001340 - - https://en.wikipedia.org/wiki/Vinblastine -- directed: true - graph: - disease: Mycosis fungoides - disease_mesh: MESH:D009182 - drug: vinblastine - drug_mesh: MESH:D014747 - drugbank: DB:DB00570 - links: - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q71U36 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:P07437 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q9UJT1 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:P23258 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q9UJT0 - - key: part of - source: UniProt:Q71U36 - target: GO:1902850 - - key: part of - source: UniProt:Q71U36 - target: GO:1902850 - - key: part of - source: UniProt:P07437 - target: GO:1902850 - - key: part of - source: UniProt:Q9UJT1 - target: GO:1902850 - - key: part of - source: UniProt:P23258 - target: GO:1902850 - - key: part of - source: UniProt:Q9UJT0 - target: GO:1902850 - - key: positively regulates - source: GO:1902850 - target: GO:0140014 - - key: positively regulates - source: GO:0140014 - target: GO:0008283 - - key: positively correlated with - source: GO:0008283 - target: MESH:D009182 - multigraph: true - nodes: - - id: MESH:D014747 - label: Drug - name: vinblastine - - id: UniProt:Q71U36 - label: Protein - name: Tubulin alpha-1A chain - - id: UniProt:P07437 - label: Protein - name: Tubulin beta chain - - id: UniProt:Q9UJT1 - label: Protein - name: Tubulin delta chain - - id: UniProt:P23258 - label: Protein - name: Tubulin gamma-1 chain - - id: UniProt:Q9UJT0 - label: Protein - name: Tubulin epsilon chain - - id: GO:1902850 - label: BiologicalProcess - name: Microtubule cytoskeleton organization involved in mitosis - - id: GO:0140014 - label: BiologicalProcess - name: Mitotic nuclear division - - id: GO:0008283 - label: BiologicalProcess - name: Cell population proliferation - - id: MESH:D009182 - label: Disease - name: Mycosis fungoides - reference: - - https://go.drugbank.com/drugs/DB00570#BE0001340 - - https://en.wikipedia.org/wiki/Vinblastine -- directed: true - graph: - disease: Non-Hodgkin's lymphoma - disease_mesh: MESH:D008228 - drug: vinblastine - drug_mesh: MESH:D014747 - drugbank: DB:DB00570 - links: - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q71U36 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:P07437 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q9UJT1 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:P23258 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q9UJT0 - - key: part of - source: UniProt:Q71U36 - target: GO:1902850 - - key: part of - source: UniProt:Q71U36 - target: GO:1902850 - - key: part of - source: UniProt:P07437 - target: GO:1902850 - - key: part of - source: UniProt:Q9UJT1 - target: GO:1902850 - - key: part of - source: UniProt:P23258 - target: GO:1902850 - - key: part of - source: UniProt:Q9UJT0 - target: GO:1902850 - - key: positively regulates - source: GO:1902850 - target: GO:0140014 - - key: positively regulates - source: GO:0140014 - target: GO:0008283 - - key: positively correlated with - source: GO:0008283 - target: MESH:D008228 - multigraph: true - nodes: - - id: MESH:D014747 - label: Drug - name: vinblastine - - id: UniProt:Q71U36 - label: Protein - name: Tubulin alpha-1A chain - - id: UniProt:P07437 - label: Protein - name: Tubulin beta chain - - id: UniProt:Q9UJT1 - label: Protein - name: Tubulin delta chain - - id: UniProt:P23258 - label: Protein - name: Tubulin gamma-1 chain - - id: UniProt:Q9UJT0 - label: Protein - name: Tubulin epsilon chain - - id: GO:1902850 - label: BiologicalProcess - name: Microtubule cytoskeleton organization involved in mitosis - - id: GO:0140014 - label: BiologicalProcess - name: Mitotic nuclear division - - id: GO:0008283 - label: BiologicalProcess - name: Cell population proliferation - - id: MESH:D008228 - label: Disease - name: Non-Hodgkin's lymphoma - reference: - - https://go.drugbank.com/drugs/DB00570#BE0001340 - - https://en.wikipedia.org/wiki/Vinblastine -- directed: true - graph: - disease: Malignant tumor of testis - disease_mesh: MESH:D013736 - drug: vinblastine - drug_mesh: MESH:D014747 - drugbank: DB:DB00570 - links: - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q71U36 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:P07437 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q9UJT1 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:P23258 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q9UJT0 - - key: part of - source: UniProt:Q71U36 - target: GO:1902850 - - key: part of - source: UniProt:Q71U36 - target: GO:1902850 - - key: part of - source: UniProt:P07437 - target: GO:1902850 - - key: part of - source: UniProt:Q9UJT1 - target: GO:1902850 - - key: part of - source: UniProt:P23258 - target: GO:1902850 - - key: part of - source: UniProt:Q9UJT0 - target: GO:1902850 - - key: positively regulates - source: GO:1902850 - target: GO:0140014 - - key: positively regulates - source: GO:0140014 - target: GO:0008283 - - key: positively correlated with - source: GO:0008283 - target: MESH:D013736 - multigraph: true - nodes: - - id: MESH:D014747 - label: Drug - name: vinblastine - - id: UniProt:Q71U36 - label: Protein - name: Tubulin alpha-1A chain - - id: UniProt:P07437 - label: Protein - name: Tubulin beta chain - - id: UniProt:Q9UJT1 - label: Protein - name: Tubulin delta chain - - id: UniProt:P23258 - label: Protein - name: Tubulin gamma-1 chain - - id: UniProt:Q9UJT0 - label: Protein - name: Tubulin epsilon chain - - id: GO:1902850 - label: BiologicalProcess - name: Microtubule cytoskeleton organization involved in mitosis - - id: GO:0140014 - label: BiologicalProcess - name: Mitotic nuclear division - - id: GO:0008283 - label: BiologicalProcess - name: Cell population proliferation - - id: MESH:D013736 - label: Disease - name: Malignant tumor of testis - reference: - - https://go.drugbank.com/drugs/DB00570#BE0001340 - - https://en.wikipedia.org/wiki/Vinblastine -- directed: true - graph: - disease: Langerhans cell histiocytosis, disseminated - disease_mesh: MESH:C538636 - drug: vinblastine - drug_mesh: MESH:D014747 - drugbank: DB:DB00570 - links: - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q71U36 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:P07437 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q9UJT1 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:P23258 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q9UJT0 - - key: part of - source: UniProt:Q71U36 - target: GO:1902850 - - key: part of - source: UniProt:Q71U36 - target: GO:1902850 - - key: part of - source: UniProt:P07437 - target: GO:1902850 - - key: part of - source: UniProt:Q9UJT1 - target: GO:1902850 - - key: part of - source: UniProt:P23258 - target: GO:1902850 - - key: part of - source: UniProt:Q9UJT0 - target: GO:1902850 - - key: positively regulates - source: GO:1902850 - target: GO:0140014 - - key: positively regulates - source: GO:0140014 - target: GO:0008283 - - key: positively correlated with - source: GO:0008283 - target: MESH:C538636 - multigraph: true - nodes: - - id: MESH:D014747 - label: Drug - name: vinblastine - - id: UniProt:Q71U36 - label: Protein - name: Tubulin alpha-1A chain - - id: UniProt:P07437 - label: Protein - name: Tubulin beta chain - - id: UniProt:Q9UJT1 - label: Protein - name: Tubulin delta chain - - id: UniProt:P23258 - label: Protein - name: Tubulin gamma-1 chain - - id: UniProt:Q9UJT0 - label: Protein - name: Tubulin epsilon chain - - id: GO:1902850 - label: BiologicalProcess - name: Microtubule cytoskeleton organization involved in mitosis - - id: GO:0140014 - label: BiologicalProcess - name: Mitotic nuclear division - - id: GO:0008283 - label: BiologicalProcess - name: Cell population proliferation - - id: MESH:C538636 - label: Disease - name: Langerhans cell histiocytosis, disseminated - reference: - - https://go.drugbank.com/drugs/DB00570#BE0001340 - - https://en.wikipedia.org/wiki/Vinblastine -- directed: true - graph: - disease: Hodgkin's disease - disease_mesh: MESH:D006689 - drug: vinblastine - drug_mesh: MESH:D014747 - drugbank: DB:DB00570 - links: - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q71U36 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:P07437 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q9UJT1 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:P23258 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q9UJT0 - - key: part of - source: UniProt:Q71U36 - target: GO:1902850 - - key: part of - source: UniProt:Q71U36 - target: GO:1902850 - - key: part of - source: UniProt:P07437 - target: GO:1902850 - - key: part of - source: UniProt:Q9UJT1 - target: GO:1902850 - - key: part of - source: UniProt:P23258 - target: GO:1902850 - - key: part of - source: UniProt:Q9UJT0 - target: GO:1902850 - - key: positively regulates - source: GO:1902850 - target: GO:0140014 - - key: positively regulates - source: GO:0140014 - target: GO:0008283 - - key: positively correlated with - source: GO:0008283 - target: MESH:D006689 - multigraph: true - nodes: - - id: MESH:D014747 - label: Drug - name: vinblastine - - id: UniProt:Q71U36 - label: Protein - name: Tubulin alpha-1A chain - - id: UniProt:P07437 - label: Protein - name: Tubulin beta chain - - id: UniProt:Q9UJT1 - label: Protein - name: Tubulin delta chain - - id: UniProt:P23258 - label: Protein - name: Tubulin gamma-1 chain - - id: UniProt:Q9UJT0 - label: Protein - name: Tubulin epsilon chain - - id: GO:1902850 - label: BiologicalProcess - name: Microtubule cytoskeleton organization involved in mitosis - - id: GO:0140014 - label: BiologicalProcess - name: Mitotic nuclear division - - id: GO:0008283 - label: BiologicalProcess - name: Cell population proliferation - - id: MESH:D006689 - label: Disease - name: Hodgkin's disease - reference: - - https://go.drugbank.com/drugs/DB00570#BE0001340 - - https://en.wikipedia.org/wiki/Vinblastine -- directed: true - graph: - disease: Gestational trophoblastic neoplasia - disease_mesh: MESH:D031901 - drug: vinblastine - drug_mesh: MESH:D014747 - drugbank: DB:DB00570 - links: - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q71U36 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:P07437 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q9UJT1 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:P23258 - - key: decreases activity of - source: MESH:D014747 - target: UniProt:Q9UJT0 - - key: part of - source: UniProt:Q71U36 - target: GO:1902850 - - key: part of - source: UniProt:Q71U36 - target: GO:1902850 - - key: part of - source: UniProt:P07437 - target: GO:1902850 - - key: part of - source: UniProt:Q9UJT1 - target: GO:1902850 - - key: part of - source: UniProt:P23258 - target: GO:1902850 - - key: part of - source: UniProt:Q9UJT0 - target: GO:1902850 - - key: positively regulates - source: GO:1902850 - target: GO:0140014 - - key: positively regulates - source: GO:0140014 - target: GO:0008283 - - key: positively correlated with - source: GO:0008283 - target: MESH:D031901 - multigraph: true - nodes: - - id: MESH:D014747 - label: Drug - name: vinblastine - - id: UniProt:Q71U36 - label: Protein - name: Tubulin alpha-1A chain - - id: UniProt:P07437 - label: Protein - name: Tubulin beta chain - - id: UniProt:Q9UJT1 - label: Protein - name: Tubulin delta chain - - id: UniProt:P23258 - label: Protein - name: Tubulin gamma-1 chain - - id: UniProt:Q9UJT0 - label: Protein - name: Tubulin epsilon chain - - id: GO:1902850 - label: BiologicalProcess - name: Microtubule cytoskeleton organization involved in mitosis - - id: GO:0140014 - label: BiologicalProcess - name: Mitotic nuclear division - - id: GO:0008283 - label: BiologicalProcess - name: Cell population proliferation - - id: MESH:D031901 - label: Disease - name: Gestational trophoblastic neoplasia - reference: - - https://go.drugbank.com/drugs/DB00570#BE0001340 - - https://en.wikipedia.org/wiki/Vinblastine -- comment: Mechanism of action of penicillamine wrt to Rheumatoid arthritis is unknown - directed: true - graph: - disease: Rheumatoid arthritis - disease_mesh: MESH:D001172 - drug: penicillamine - drug_mesh: MESH:D010396 - drugbank: DB:DB00859 - links: - - key: capable of - source: MESH:D010396 - target: GO:0046911 - - key: decreases activity of - source: GO:0046911 - target: CL:0000084 - - key: participates in - source: CL:0000084 - target: GO:0006955 - - key: positively correlated with - source: GO:0006955 - target: GO:0006954 - - key: causes - source: GO:0006954 - target: MESH:D001172 - multigraph: true - nodes: - - id: MESH:D010396 - label: Drug - name: penicillamine - - id: GO:0046911 - label: MolecularActivity - name: metal chelating activity - - id: CL:0000084 - label: Cell - name: T cell - - id: GO:0006955 - label: BiologicalProcess - name: Immune response - - id: GO:0006954 - label: BiologicalProcess - name: Inflammation - - id: MESH:D001172 - label: Disease - name: Rheumatoid arthritis - reference: - - https://go.drugbank.com/drugs/DB00859 - - https://www.sciencedirect.com/science/article/pii/B9780080280240500165 -- directed: true - graph: - disease: Wilson's disease - disease_mesh: MESH:D006527 - drug: penicillamine - drug_mesh: MESH:D010396 - drugbank: DB:DB00859 - links: - - key: capable of - source: MESH:D010396 - target: GO:0046911 - - key: decreases abundance of - source: GO:0046911 - target: MESH:D003300 - - key: regulates - source: MESH:D003300 - target: GO:0055070 - - key: treats - source: GO:0055070 - target: MESH:D006527 - multigraph: true - nodes: - - id: MESH:D010396 - label: Drug - name: penicillamine - - id: GO:0046911 - label: MolecularActivity - name: metal chelating activity - - id: MESH:D003300 - label: ChemicalSubstance - name: Copper - - id: GO:0055070 - label: BiologicalProcess - name: Copper ion homeostasis - - id: MESH:D006527 - label: Disease - name: Wilson's disease - reference: - - https://go.drugbank.com/drugs/DB00859 - - https://pubmed.ncbi.nlm.nih.gov/22802922/ -- directed: true - graph: - disease: Cystinuria - disease_mesh: MESH:D003555 - drug: penicillamine - drug_mesh: MESH:D010396 - drugbank: DB:DB00859 - links: - - key: capable of - source: MESH:D010396 - target: GO:0046911 - - key: decreases abundance of - source: GO:0046911 - target: CHEBI:17376 - - key: causes - source: CHEBI:17376 - target: HP:0003131 - - key: manifestation of - source: HP:0003131 - target: MESH:D003555 - multigraph: true - nodes: - - id: MESH:D010396 - label: Drug - name: penicillamine - - id: GO:0046911 - label: MolecularActivity - name: metal chelating activity - - id: CHEBI:17376 - label: ChemicalSubstance - name: cystine - - id: HP:0003131 - label: PhenotypicFeature - name: Cystinuria - - id: MESH:D003555 - label: Disease - name: Cystinuria - reference: - - https://go.drugbank.com/drugs/DB00859 -- directed: true - graph: - disease: Gastrointestinal stromal tumor - disease_mesh: MESH:D046152 - drug: sunitinib - drug_mesh: MESH:C473478 - drugbank: DB:DB01268 - links: - - key: decreases activity of - source: MESH:C473478 - target: UniProt:P09619 - - key: decreases activity of - source: MESH:C473478 - target: UniProt:P17948 - - key: decreases activity of - source: MESH:C473478 - target: UniProt:P10721 - - key: decreases activity of - source: MESH:C473478 - target: UniProt:P35968 - - key: decreases activity of - source: MESH:C473478 - target: UniProt:P35916 - - key: decreases activity of - source: MESH:C473478 - target: UniProt:P36888 - - key: decreases activity of - source: MESH:C473478 - target: UniProt:P07333 - - key: decreases activity of - source: MESH:C473478 - target: UniProt:P16234 - - key: positively regulates - source: UniProt:P09619 - target: GO:0008284 - - key: positively regulates - source: UniProt:P17948 - target: GO:0008284 - - key: positively regulates - source: UniProt:P10721 - target: GO:0008284 - - key: positively regulates - source: UniProt:P35968 - target: GO:0008284 - - key: positively regulates - source: UniProt:P35916 - target: GO:0008284 - - key: positively regulates - source: UniProt:P36888 - target: GO:0008284 - - key: positively regulates - source: UniProt:P07333 - target: GO:0008284 - - key: positively regulates - source: UniProt:P16234 - target: GO:0008284 - - key: positively regulates - source: UniProt:P09619 - target: GO:0045766 - - key: positively regulates - source: UniProt:P17948 - target: GO:0045766 - - key: positively regulates - source: UniProt:P10721 - target: GO:0045766 - - key: positively regulates - source: UniProt:P35968 - target: GO:0045766 - - key: positively regulates - source: UniProt:P35916 - target: GO:0045766 - - key: positively regulates - source: UniProt:P36888 - target: GO:0045766 - - key: positively regulates - source: UniProt:P07333 - target: GO:0045766 - - key: positively regulates - source: UniProt:P16234 - target: GO:0045766 - - key: located in - source: GO:0045766 - target: CL:0001064 - - key: located in - source: GO:0008284 - target: CL:0001064 - - key: participates in - source: CL:0001064 - target: MESH:D046152 - multigraph: true - nodes: - - id: MESH:C473478 - label: Drug - name: sunitinib - - id: UniProt:P09619 - label: Protein - name: Platelet-derived growth factor receptor beta - - id: UniProt:P17948 - label: Protein - name: Vascular endothelial growth factor receptor 1 - - id: UniProt:P10721 - label: Protein - name: Mast/stem cell growth factor receptor Kit - - id: UniProt:P35968 - label: Protein - name: Vascular endothelial growth factor receptor 2 - - id: UniProt:P35916 - label: Protein - name: Vascular endothelial growth factor receptor 3 - - id: UniProt:P36888 - label: Protein - name: Receptor-type tyrosine-protein kinase FLT3 - - id: UniProt:P07333 - label: Protein - name: Macrophage colony-stimulating factor 1 receptor - - id: UniProt:P16234 - label: Protein - name: Platelet-derived growth factor receptor alpha - - id: GO:0008284 - label: BiologicalProcess - name: positive regulation of cell population proliferation - - id: GO:0045766 - label: BiologicalProcess - name: positive regulation of angiogenesis - - id: CL:0001064 - label: Cell - name: cancer cell - - id: MESH:D046152 - label: Disease - name: Gastrointestinal stromal tumor - reference: - - https://go.drugbank.com/drugs/DB01268 - - https://pubmed.ncbi.nlm.nih.gov/20110785/ -- directed: true - graph: - disease: Renal cell carcinoma - disease_mesh: MESH:D002292 - drug: sunitinib - drug_mesh: MESH:C473478 - drugbank: DB:DB01268 - links: - - key: decreases activity of - source: MESH:C473478 - target: UniProt:P09619 - - key: decreases activity of - source: MESH:C473478 - target: UniProt:P17948 - - key: decreases activity of - source: MESH:C473478 - target: UniProt:P10721 - - key: decreases activity of - source: MESH:C473478 - target: UniProt:P35968 - - key: decreases activity of - source: MESH:C473478 - target: UniProt:P35916 - - key: decreases activity of - source: MESH:C473478 - target: UniProt:P36888 - - key: decreases activity of - source: MESH:C473478 - target: UniProt:P07333 - - key: decreases activity of - source: MESH:C473478 - target: UniProt:P16234 - - key: positively regulates - source: UniProt:P09619 - target: GO:0008284 - - key: positively regulates - source: UniProt:P17948 - target: GO:0008284 - - key: positively regulates - source: UniProt:P10721 - target: GO:0008284 - - key: positively regulates - source: UniProt:P35968 - target: GO:0008284 - - key: positively regulates - source: UniProt:P35916 - target: GO:0008284 - - key: positively regulates - source: UniProt:P36888 - target: GO:0008284 - - key: positively regulates - source: UniProt:P07333 - target: GO:0008284 - - key: positively regulates - source: UniProt:P16234 - target: GO:0008284 - - key: positively regulates - source: UniProt:P09619 - target: GO:0045766 - - key: positively regulates - source: UniProt:P17948 - target: GO:0045766 - - key: positively regulates - source: UniProt:P10721 - target: GO:0045766 - - key: positively regulates - source: UniProt:P35968 - target: GO:0045766 - - key: positively regulates - source: UniProt:P35916 - target: GO:0045766 - - key: positively regulates - source: UniProt:P36888 - target: GO:0045766 - - key: positively regulates - source: UniProt:P07333 - target: GO:0045766 - - key: positively regulates - source: UniProt:P16234 - target: GO:0045766 - - key: located in - source: GO:0045766 - target: CL:0001064 - - key: located in - source: GO:0008284 - target: CL:0001064 - - key: participates in - source: CL:0001064 - target: MESH:D002292 - multigraph: true - nodes: - - id: MESH:C473478 - label: Drug - name: sunitinib - - id: UniProt:P09619 - label: Protein - name: Platelet-derived growth factor receptor beta - - id: UniProt:P17948 - label: Protein - name: Vascular endothelial growth factor receptor 1 - - id: UniProt:P10721 - label: Protein - name: Mast/stem cell growth factor receptor Kit - - id: UniProt:P35968 - label: Protein - name: Vascular endothelial growth factor receptor 2 - - id: UniProt:P35916 - label: Protein - name: Vascular endothelial growth factor receptor 3 - - id: UniProt:P36888 - label: Protein - name: Receptor-type tyrosine-protein kinase FLT3 - - id: UniProt:P07333 - label: Protein - name: Macrophage colony-stimulating factor 1 receptor - - id: UniProt:P16234 - label: Protein - name: Platelet-derived growth factor receptor alpha - - id: GO:0008284 - label: BiologicalProcess - name: positive regulation of cell population proliferation - - id: GO:0045766 - label: BiologicalProcess - name: positive regulation of angiogenesis - - id: CL:0001064 - label: Cell - name: cancer cell - - id: MESH:D002292 - label: Disease - name: Renal cell carcinoma - reference: - - https://go.drugbank.com/drugs/DB01268 - - https://pubmed.ncbi.nlm.nih.gov/20110785/ -- directed: true - graph: - disease: Laron-type isolated somatotropin defect - disease_mesh: MESH:D046150 - drug: mecasermin - drug_mesh: MESH:C000604197 - drugbank: DB:DB01277 - links: - - key: chemically similar to - source: MESH:C000604197 - target: UniProt:P05019 - - key: increases activity of - source: UniProt:P05019 - target: UniProt:P08069 - - key: participates in - source: UniProt:P08069 - target: GO:0035988 - - key: participates in - source: UniProt:P08069 - target: GO:0003423 - - key: participates in - source: UniProt:P08069 - target: GO:0046622 - - key: negatively correlated with - source: GO:0035988 - target: HP:0003510 - - key: negatively correlated with - source: GO:0003423 - target: HP:0003510 - - key: negatively correlated with - source: GO:0046622 - target: HP:0003510 - - key: correlated with - source: HP:0003510 - target: MESH:D046150 - multigraph: true - nodes: - - id: MESH:C000604197 - label: Drug - name: mecasermin - - id: UniProt:P05019 - label: Protein - name: Insulin-like growth factor I - - id: UniProt:P08069 - label: Protein - name: Insulin-like growth factor 1 receptor - - id: GO:0035988 - label: BiologicalProcess - name: chondrocyte proliferation - - id: GO:0003423 - label: BiologicalProcess - name: growth plate cartilage chondrocyte division - - id: GO:0046622 - label: BiologicalProcess - name: positive regulation of organ growth - - id: HP:0003510 - label: PhenotypicFeature - name: Severe short stature - - id: MESH:D046150 - label: Disease - name: Laron-type isolated somatotropin defect - reference: - - https://go.drugbank.com/drugs/DB01277 - - https://pubmed.ncbi.nlm.nih.gov/19198769/ +