diff --git a/submission.yaml b/submission.yaml
index 8b1378917..f68c42e9b 100644
--- a/submission.yaml
+++ b/submission.yaml
@@ -1 +1,1578 @@
+- directed: true
+  graph:
+    _id: DB00994_MESH_D006501_1
+    disease: Hepatic encephalopathy
+    disease_mesh: MESH:D006501
+    drug: neomycin
+    drug_mesh: MESH:D009355
+    drugbank: DB:DB00994
+  links:
+    - key: decreases activity of
+      source: MESH:D009355
+      target: CHEBI:18111
+    - key: in taxon
+      source: CHEBI:18111
+      target: NCBITaxon:562
+    - key: regulates
+      source: NCBITaxon:562
+      target: GO:0097272
+    - key: prevents
+      source: GO:0097272
+      target: HP:0001987
+    - key: positively correlated with
+      source: HP:0001987
+      target: MESH:D006501
+  multigraph: true
+  nodes:
+    - id: MESH:D009355
+      label: Drug
+      name: neomycin
+    - id: CHEBI:18111
+      label: ChemicalSubstance
+      name: ribosomal RNA
+    - id: NCBITaxon:562
+      label: OrganismTaxon
+      name: Escherichia coli
+    - id: GO:0097272
+      label: BiologicalProcess
+      name: ammonium homeostasis
+    - id: HP:0001987
+      label: PhenotypicFeature
+      name: Hyperammonemia
+    - id: MESH:D006501
+      label: Disease
+      name: Hepatic encephalopathy
+  reference: https://go.drugbank.com/drugs/DB00994#mechanism-of-action
+- directed: true
+  graph:
+    _id: DB00994_MESH_D007634_1
+    disease: Keratitis
+    disease_mesh: MESH:D007634
+    drug: neomycin
+    drug_mesh: MESH:D009355
+    drugbank: DB:DB00994
+  links:
+    - key: decreases activity of
+      source: MESH:D009355
+      target: CHEBI:18111
+    - key: participates in
+      source: CHEBI:18111
+      target: GO:0006412
+    - key: in taxon
+      source: GO:0006412
+      target: NCBITaxon:1280
+    - key: causes
+      source: NCBITaxon:1280
+      target: MESH:D007634
+  multigraph: true
+  nodes:
+    - id: MESH:D009355
+      label: Drug
+      name: neomycin
+    - id: CHEBI:18111
+      label: ChemicalSubstance
+      name: ribosomal RNA
+    - id: GO:0006412
+      label: BiologicalProcess
+      name: Translation
+    - id: NCBITaxon:1280
+      label: OrganismTaxon
+      name: Staphylococcus aureus
+    - id: MESH:D007634
+      label: Disease
+      name: Keratitis
+  reference: https://go.drugbank.com/drugs/DB00994#mechanism-of-action
+- directed: true
+  graph:
+    _id: DB00994_MESH_D010032_1
+    disease: Otitis externa
+    disease_mesh: MESH:D010032
+    drug: neomycin
+    drug_mesh: MESH:D009355
+    drugbank: DB:DB00994
+  links:
+    - key: decreases activity of
+      source: MESH:D009355
+      target: CHEBI:18111
+    - key: participates in
+      source: CHEBI:18111
+      target: GO:0006412
+    - key: in taxon
+      source: GO:0006412
+      target: NCBITaxon:1280
+    - key: causes
+      source: NCBITaxon:1280
+      target: MESH:D010032
+  multigraph: true
+  nodes:
+    - id: MESH:D009355
+      label: Drug
+      name: neomycin
+    - id: CHEBI:18111
+      label: ChemicalSubstance
+      name: ribosomal RNA
+    - id: GO:0006412
+      label: BiologicalProcess
+      name: Translation
+    - id: NCBITaxon:1280
+      label: OrganismTaxon
+      name: Staphylococcus aureus
+    - id: MESH:D010032
+      label: Disease
+      name: Otitis externa
+  reference: https://go.drugbank.com/drugs/DB00994#mechanism-of-action
+- directed: true
+  graph:
+    _id: DB00994_MESH_D014552_1
+    disease: Urinary tract infectious disease
+    disease_mesh: MESH:D014552
+    drug: neomycin
+    drug_mesh: MESH:D009355
+    drugbank: DB:DB00994
+  links:
+    - key: decreases activity of
+      source: MESH:D009355
+      target: CHEBI:18111
+    - key: participates in
+      source: CHEBI:18111
+      target: GO:0006412
+    - key: in taxon
+      source: GO:0006412
+      target: NCBITaxon:562
+    - key: causes
+      source: NCBITaxon:562
+      target: MESH:D014552
+  multigraph: true
+  nodes:
+    - id: MESH:D009355
+      label: Drug
+      name: neomycin
+    - id: CHEBI:18111
+      label: ChemicalSubstance
+      name: ribosomal RNA
+    - id: GO:0006412
+      label: BiologicalProcess
+      name: Translation
+    - id: NCBITaxon:562
+      label: OrganismTaxon
+      name: Escherichia coli
+    - id: MESH:D014552
+      label: Disease
+      name: Urinary tract infectious disease
+  reference: https://go.drugbank.com/drugs/DB00994#mechanism-of-action
+- directed: true
+  graph:
+    _id: DB00994_MESH_D014605_1
+    disease: Uveitis
+    disease_mesh: MESH:D014605
+    drug: neomycin
+    drug_mesh: MESH:D009355
+    drugbank: DB:DB00994
+  links:
+    - key: decreases activity of
+      source: MESH:D009355
+      target: CHEBI:18111
+    - key: participates in
+      source: CHEBI:18111
+      target: GO:0006412
+    - key: in taxon
+      source: GO:0006412
+      target: NCBITaxon:562
+    - key: causes
+      source: NCBITaxon:562
+      target: MESH:D014605
+  multigraph: true
+  nodes:
+    - id: MESH:D009355
+      label: Drug
+      name: neomycin
+    - id: CHEBI:18111
+      label: ChemicalSubstance
+      name: ribosomal RNA
+    - id: GO:0006412
+      label: BiologicalProcess
+      name: Translation
+    - id: NCBITaxon:562
+      label: OrganismTaxon
+      name: Escherichia coli
+    - id: MESH:D014605
+      label: Disease
+      name: Uveitis
+  reference: https://go.drugbank.com/drugs/DB00994#mechanism-of-action
+- directed: true
+  graph:
+    _id: DB01049_MESH_D003704_1
+    disease: Dementia
+    disease_mesh: MESH:D003704
+    drug: Ergoloid mesylates
+    drug_mesh: MESH:D004877
+    drugbank: DB:DB01049
+  links:
+    - key: positively regulates
+      source: MESH:D004877
+      target: InterPro:IPR000929
+    - key: positively regulates
+      source: MESH:D004877
+      target: InterPro:IPR002231
+    - key: negatively regulates
+      source: MESH:D004877
+      target: InterPro:IPR002233
+    - key: positively correlated with
+      source: InterPro:IPR000929
+      target: GO:0001963
+    - key: positively correlated with
+      source: InterPro:IPR002231
+      target: GO:0007271
+    - key: positively correlated with
+      source: InterPro:IPR002231
+      target: GO:0001963
+    - key: positively correlated with
+      source: InterPro:IPR002231
+      target: GO:0035249
+    - key: positively correlated with
+      source: InterPro:IPR002231
+      target: GO:0051932
+    - key: negatively correlated with
+      source: GO:0007271
+      target: HP:0001268
+    - key: negatively correlated with
+      source: GO:0035249
+      target: HP:0001268
+    - key: negatively correlated with
+      source: GO:0051932
+      target: HP:0001268
+    - key: positively correlated with
+      source: InterPro:IPR002233
+      target: GO:0042310
+    - key: positively correlated with
+      source: GO:0042310
+      target: HP:0002354
+    - key: manifestation of
+      source: HP:0002354
+      target: MESH:D003704
+    - key: negatively correlated with
+      source: GO:0001963
+      target: HP:0001268
+    - key: manifestation of
+      source: HP:0001268
+      target: MESH:D003704
+  multigraph: true
+  nodes:
+    - id: MESH:D004877
+      label: Drug
+      name: Ergoloid mesylates
+    - id: InterPro:IPR000929
+      label: GeneFamily
+      name: Dopamine receptor family
+    - id: InterPro:IPR002233
+      label: GeneFamily
+      name: Adrenoceptor family
+    - id: InterPro:IPR002231
+      label: GeneFamily
+      name: 5-hydroxytryptamine receptor family
 
+    - id: GO:0001963
+      label: BiologicalProcess
+      name: synaptic transmission, dopaminergic
+    - id: GO:0007271
+      label: BiologicalProcess
+      name: synaptic transmission, cholinergic
+    - id: GO:0035249
+      label: BiologicalProcess
+      name: synaptic transmission, glutamatergic
+    - id: GO:0051932
+      label: BiologicalProcess
+      name: synaptic transmission, GABAergic
+    - id: GO:0042310
+      label: BiologicalProcess
+      name: vasoconstriction
+    - id: HP:0002354
+      label: PhenotypicFeature
+      name: Memory impairment
+    - id: HP:0001268
+      label: PhenotypicFeature
+      name: Mental deterioration
+    - id: MESH:D003704
+      label: Disease
+      name: Dementia
+  reference:
+    - https://go.drugbank.com/drugs/DB01049#mechanism-of-action
+    - https://en.wikipedia.org/wiki/Ergoloid#Mechanism_of_action
+    - https://selfhacked.com/blog/hydergine/#Mechanism_of_Action
+    - https://en.wikipedia.org/wiki/5-HT_receptor
+  comment: This drug seems to have mixed effects in the dopamine, serotonin, and noradrenaline systems (https://pubmed.ncbi.nlm.nih.gov/2869188/), suggesting it can compensate for deficits in disease and in aging while preventing the pathological effects that result from excessive activity in these systems in normal individuals. This drug is contraindicated in patients who have psychosis, acute or chronic (https://en.wikipedia.org/wiki/Ergoloid#Contraindications).
+- directed: true
+  graph:
+    _id: DB09213_MESH_D001172_1
+    disease: Rheumatoid arthritis
+    disease_mesh: MESH:D001172
+    drug: dexibuprofen
+    drug_mesh: MESH:C539402
+    drugbank: DB:DB09213
+  links:
+    - key: decreases activity of
+      source: MESH:C539402
+      target: UniProt:P23219
+    - key: decreases activity of
+      source: MESH:C539402
+      target: UniProt:P35354
+    - key: participates in
+      source: UniProt:P23219
+      target: REACT:R-HSA-2162123
+    - key: participates in
+      source: UniProt:P35354
+      target: REACT:R-HSA-2162123
+    - key: increases abundance of
+      source: REACT:R-HSA-2162123
+      target: MESH:D011453
+    - key: positively correlated with
+      source: MESH:D011453
+      target: HP:0002829
+    - key: positively correlated with
+      source: MESH:D011453
+      target: HP:0001386
+    - key: positively correlated with
+      source: HP:0001386
+      target: MESH:D001172
+    - key: positively correlated with
+      source: HP:0002829
+      target: MESH:D001172
+  multigraph: true
+  nodes:
+    - id: MESH:C539402
+      label: Drug
+      name: dexibuprofen
+    - id: UniProt:P23219
+      label: Protein
+      name: Prostaglandin G/H synthase 1
+    - id: UniProt:P35354
+      label: Protein
+      name: Prostaglandin G/H synthase 2
+    - id: REACT:R-HSA-2162123
+      label: Pathway
+      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    - id: MESH:D011453
+      label: ChemicalSubstance
+      name: Prostaglandins
+    - id: HP:0002829
+      label: PhenotypicFeature
+      name: Joint pain
+    - id: HP:0001386
+      label: PhenotypicFeature
+      name: Joint swelling
+    - id: MESH:D001172
+      label: Disease
+      name: Rheumatoid arthritis
+  reference:
+    - https://go.drugbank.com/drugs/DB09213#BE0000262
+    - https://go.drugbank.com/drugs/DB09213#BE0000017
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL175/
+    - https://en.wikipedia.org/wiki/Ibuprofen#Pharmacology
+  comment: Dexibuprofen is an active enantiomer of ibuprofen.
+- directed: true
+  graph:
+    _id: DB09213_MESH_D001171_1
+    disease: Arthritis, Juvenile
+    disease_mesh: MESH:D001171
+    drug: dexibuprofen
+    drug_mesh: MESH:C539402
+    drugbank: DB:DB09213
+  links:
+    - key: decreases activity of
+      source: MESH:C539402
+      target: UniProt:P23219
+    - key: decreases activity of
+      source: MESH:C539402
+      target: UniProt:P35354
+    - key: participates in
+      source: UniProt:P23219
+      target: REACT:R-HSA-2162123
+    - key: participates in
+      source: UniProt:P35354
+      target: REACT:R-HSA-2162123
+    - key: increases abundance of
+      source: REACT:R-HSA-2162123
+      target: MESH:D011453
+    - key: positively correlated with
+      source: MESH:D011453
+      target: HP:0002829
+    - key: positively correlated with
+      source: MESH:D011453
+      target: HP:0001386
+    - key: positively correlated with
+      source: HP:0001386
+      target: MESH:D001171
+    - key: positively correlated with
+      source: HP:0002829
+      target: MESH:D001171
+  multigraph: true
+  nodes:
+    - id: MESH:C539402
+      label: Drug
+      name: dexibuprofen
+    - id: UniProt:P23219
+      label: Protein
+      name: Prostaglandin G/H synthase 1
+    - id: UniProt:P35354
+      label: Protein
+      name: Prostaglandin G/H synthase 2
+    - id: REACT:R-HSA-2162123
+      label: Pathway
+      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    - id: MESH:D011453
+      label: ChemicalSubstance
+      name: Prostaglandins
+    - id: HP:0002829
+      label: PhenotypicFeature
+      name: Joint pain
+    - id: HP:0001386
+      label: PhenotypicFeature
+      name: Joint swelling
+    - id: MESH:D001171
+      label: Disease
+      name: Arthritis, Juvenile
+  reference:
+    - https://go.drugbank.com/drugs/DB09213#BE0000262
+    - https://go.drugbank.com/drugs/DB09213#BE0000017
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL175/
+    - https://en.wikipedia.org/wiki/Ibuprofen#Pharmacology
+  comment: The disease is denoted as Juvenile rheumatoid arthritis as per DrugCentral. Dexibuprofen is an active enantiomer of ibuprofen.
+- directed: true
+  graph:
+    _id: DB09213_MESH_D010003_1
+    disease: Osteoarthritis
+    disease_mesh: MESH:D010003
+    drug: dexibuprofen
+    drug_mesh: MESH:C539402
+    drugbank: DB:DB09213
+  links:
+    - key: decreases activity of
+      source: MESH:C539402
+      target: UniProt:P23219
+    - key: decreases activity of
+      source: MESH:C539402
+      target: UniProt:P35354
+    - key: participates in
+      source: UniProt:P23219
+      target: REACT:R-HSA-2162123
+    - key: participates in
+      source: UniProt:P35354
+      target: REACT:R-HSA-2162123
+    - key: increases abundance of
+      source: REACT:R-HSA-2162123
+      target: MESH:D011453
+    - key: positively correlated with
+      source: MESH:D011453
+      target: HP:0002829
+    - key: positively correlated with
+      source: MESH:D011453
+      target: HP:0001386
+    - key: positively correlated with
+      source: HP:0001386
+      target: MESH:D010003
+    - key: positively correlated with
+      source: HP:0002829
+      target: MESH:D010003
+  multigraph: true
+  nodes:
+    - id: MESH:C539402
+      label: Drug
+      name: dexibuprofen
+    - id: UniProt:P23219
+      label: Protein
+      name: Prostaglandin G/H synthase 1
+    - id: UniProt:P35354
+      label: Protein
+      name: Prostaglandin G/H synthase 2
+    - id: REACT:R-HSA-2162123
+      label: Pathway
+      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    - id: MESH:D011453
+      label: ChemicalSubstance
+      name: Prostaglandins
+    - id: HP:0002829
+      label: PhenotypicFeature
+      name: Joint pain
+    - id: HP:0001386
+      label: PhenotypicFeature
+      name: Joint swelling
+    - id: MESH:D010003
+      label: Disease
+      name: Osteoarthritis
+  reference:
+    - https://go.drugbank.com/drugs/DB09213#BE0000262
+    - https://go.drugbank.com/drugs/DB09213#BE0000017
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL175/
+    - https://en.wikipedia.org/wiki/Ibuprofen#Pharmacology
+  comment: Dexibuprofen is an active enantiomer of ibuprofen.
+- directed: true
+  graph:
+    _id: DB09213_MESH_D005334_1
+    disease: Fever
+    disease_mesh: MESH:D005334
+    drug: dexibuprofen
+    drug_mesh: MESH:C539402
+    drugbank: DB:DB09213
+  links:
+    - key: decreases activity of
+      source: MESH:C539402
+      target: UniProt:P23219
+    - key: decreases activity of
+      source: MESH:C539402
+      target: UniProt:P35354
+    - key: participates in
+      source: UniProt:P23219
+      target: REACT:R-HSA-2162123
+    - key: participates in
+      source: UniProt:P35354
+      target: REACT:R-HSA-2162123
+    - key: increases abundance of
+      source: REACT:R-HSA-2162123
+      target: MESH:D011453
+    - key: positively correlated with
+      source: MESH:D011453
+      target: MESH:D005334
+  multigraph: true
+  nodes:
+    - id: MESH:C539402
+      label: Drug
+      name: dexibuprofen
+    - id: UniProt:P23219
+      label: Protein
+      name: Prostaglandin G/H synthase 1
+    - id: UniProt:P35354
+      label: Protein
+      name: Prostaglandin G/H synthase 2
+    - id: REACT:R-HSA-2162123
+      label: Pathway
+      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    - id: MESH:D011453
+      label: ChemicalSubstance
+      name: Prostaglandins
+    - id: MESH:D005334
+      label: Disease
+      name: Fever
+  reference:
+    - https://go.drugbank.com/drugs/DB09213#BE0000262
+    - https://go.drugbank.com/drugs/DB09213#BE0000017
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL175/
+    - https://en.wikipedia.org/wiki/Ibuprofen#Pharmacology
+    - https://en.wikipedia.org/wiki/Fever#PGE2_release
+  comment: Dexibuprofen is an active enantiomer of ibuprofen.
+- directed: true
+  graph:
+    _id: DB09213_MESH_D010146_1
+    disease: Pain
+    disease_mesh: MESH:D010146
+    drug: dexibuprofen
+    drug_mesh: MESH:C539402
+    drugbank: DB:DB09213
+  links:
+    - key: decreases activity of
+      source: MESH:C539402
+      target: UniProt:P23219
+    - key: decreases activity of
+      source: MESH:C539402
+      target: UniProt:P35354
+    - key: participates in
+      source: UniProt:P23219
+      target: REACT:R-HSA-2162123
+    - key: participates in
+      source: UniProt:P35354
+      target: REACT:R-HSA-2162123
+    - key: increases abundance of
+      source: REACT:R-HSA-2162123
+      target: MESH:D011453
+    - key: positively correlated with
+      source: MESH:D011453
+      target: MESH:D010146
+  multigraph: true
+  nodes:
+    - id: MESH:C539402
+      label: Drug
+      name: dexibuprofen
+    - id: UniProt:P23219
+      label: Protein
+      name: Prostaglandin G/H synthase 1
+    - id: UniProt:P35354
+      label: Protein
+      name: Prostaglandin G/H synthase 2
+    - id: REACT:R-HSA-2162123
+      label: Pathway
+      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    - id: MESH:D011453
+      label: ChemicalSubstance
+      name: Prostaglandins
+    - id: MESH:D010146
+      label: Disease
+      name: Pain
+  reference:
+    - https://go.drugbank.com/drugs/DB09213#BE0000262
+    - https://go.drugbank.com/drugs/DB09213#BE0000017
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL175/
+    - https://en.wikipedia.org/wiki/Ibuprofen#Pharmacology
+    - https://en.wikipedia.org/wiki/Fever#PGE2_release
+  comment: Dexibuprofen is an active enantiomer of ibuprofen.
+- directed: true
+  graph:
+    _id: DB09213_MESH_D006261_1
+    disease: Headache Disorders
+    disease_mesh: MESH:D006261
+    drug: dexibuprofen
+    drug_mesh: MESH:C539402
+    drugbank: DB:DB09213
+  links:
+    - key: decreases activity of
+      source: MESH:C539402
+      target: UniProt:P23219
+    - key: decreases activity of
+      source: MESH:C539402
+      target: UniProt:P35354
+    - key: participates in
+      source: UniProt:P23219
+      target: REACT:R-HSA-2162123
+    - key: participates in
+      source: UniProt:P35354
+      target: REACT:R-HSA-2162123
+    - key: increases abundance of
+      source: REACT:R-HSA-2162123
+      target: MESH:D011453
+    - key: positively correlated with
+      source: MESH:D011453
+      target: HP:0012531
+    - key: manifestation of
+      source: HP:0012531
+      target: MESH:D006261
+  multigraph: true
+  nodes:
+    - id: MESH:C539402
+      label: Drug
+      name: dexibuprofen
+    - id: UniProt:P23219
+      label: Protein
+      name: Prostaglandin G/H synthase 1
+    - id: UniProt:P35354
+      label: Protein
+      name: Prostaglandin G/H synthase 2
+    - id: REACT:R-HSA-2162123
+      label: Pathway
+      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    - id: MESH:D011453
+      label: ChemicalSubstance
+      name: Prostaglandins
+    - id: HP:0012531
+      label: PhenotypicFeature
+      name: Pain
+    - id: MESH:D006261
+      label: Disease
+      name: Headache Disorders
+  reference:
+    - https://go.drugbank.com/drugs/DB09213#BE0000262
+    - https://go.drugbank.com/drugs/DB09213#BE0000017
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL175/
+    - https://en.wikipedia.org/wiki/Ibuprofen#Pharmacology
+    - https://en.wikipedia.org/wiki/Fever#PGE2_release
+  comment: Dexibuprofen is an active enantiomer of ibuprofen.
+- directed: true
+  graph:
+    _id: DB09213_MESH_D004412_1
+    disease: Dysmenorrhea
+    disease_mesh: MESH:D004412
+    drug: dexibuprofen
+    drug_mesh: MESH:C539402
+    drugbank: DB:DB09213
+  links:
+    - key: decreases activity of
+      source: MESH:C539402
+      target: UniProt:P23219
+    - key: decreases activity of
+      source: MESH:C539402
+      target: UniProt:P35354
+    - key: participates in
+      source: UniProt:P23219
+      target: REACT:R-HSA-2162123
+    - key: participates in
+      source: UniProt:P35354
+      target: REACT:R-HSA-2162123
+    - key: increases abundance of
+      source: REACT:R-HSA-2162123
+      target: MESH:D011453
+    - key: positively correlated with
+      source: MESH:D011453
+      target: HP:0012531
+    - key: manifestation of
+      source: HP:0012531
+      target: MESH:D004412
+  multigraph: true
+  nodes:
+    - id: MESH:C539402
+      label: Drug
+      name: dexibuprofen
+    - id: UniProt:P23219
+      label: Protein
+      name: Prostaglandin G/H synthase 1
+    - id: UniProt:P35354
+      label: Protein
+      name: Prostaglandin G/H synthase 2
+    - id: REACT:R-HSA-2162123
+      label: Pathway
+      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    - id: MESH:D011453
+      label: ChemicalSubstance
+      name: Prostaglandins
+    - id: HP:0012531
+      label: PhenotypicFeature
+      name: Pain
+    - id: MESH:D004412
+      label: Disease
+      name: Dysmenorrhea
+  reference:
+    - https://go.drugbank.com/drugs/DB09213#BE0000262
+    - https://go.drugbank.com/drugs/DB09213#BE0000017
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL175/
+    - https://en.wikipedia.org/wiki/Ibuprofen#Pharmacology
+    - https://en.wikipedia.org/wiki/Fever#PGE2_release
+  comment: Dexibuprofen is an active enantiomer of ibuprofen.
+- directed: true
+  graph:
+    _id: DB01009_MESH_D001172_1
+    disease: Rheumatoid arthritis
+    disease_mesh: MESH:D001172
+    drug: ketoprofen
+    drug_mesh: MESH:D007660
+    drugbank: DB:DB01009
+  links:
+    - key: negatively regulates
+      source: MESH:D007660
+      target: UniProt:P23219
+    - key: negatively regulates
+      source: MESH:D007660
+      target: UniProt:P35354
+    - key: participates in
+      source: UniProt:P23219
+      target: REACT:R-HSA-2162123
+    - key: participates in
+      source: UniProt:P35354
+      target: REACT:R-HSA-2162123
+    - key: increases abundance of
+      source: REACT:R-HSA-2162123
+      target: MESH:D011453
+    - key: positively correlated with
+      source: MESH:D011453
+      target: HP:0005059
+    - key: positively correlated with
+      source: MESH:D011453
+      target: HP:0001386
+    - key: positively correlated with
+      source: HP:0001386
+      target: MESH:D001172
+    - key: positively correlated with
+      source: HP:0005059
+      target: MESH:D001172
+  multigraph: true
+  nodes:
+    - id: MESH:D007660
+      label: Drug
+      name: ketoprofen
+    - id: UniProt:P23219
+      label: Protein
+      name: Prostaglandin G/H synthase 1
+    - id: UniProt:P35354
+      label: Protein
+      name: Prostaglandin G/H synthase 2
+    - id: REACT:R-HSA-2162123
+      label: Pathway
+      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    - id: MESH:D011453
+      label: ChemicalSubstance
+      name: Prostaglandins
+    - id: HP:0005059
+      label: PhenotypicFeature
+      name: Joint pain/Joint inflammation
+    - id: HP:0001386
+      label: PhenotypicFeature
+      name: Joint swelling
+    - id: MESH:D001172
+      label: Disease
+      name: Rheumatoid arthritis
+  reference:
+    - https://go.drugbank.com/drugs/DB01009#mechanism-of-action
+    - https://en.wikipedia.org/wiki/Ketoprofen#Mechanism
+    - https://en.wikipedia.org/wiki/Rheumatoid_arthritis#Anti-inflammatory_and_analgesic_agents
+- directed: true
+  graph:
+    _id: DB01009_MESH_D010146_1
+    disease: Pain
+    disease_mesh: MESH:D010146
+    drug: ketoprofen
+    drug_mesh: MESH:D007660
+    drugbank: DB:DB01009
+  links:
+    - key: negatively regulates
+      source: MESH:D007660
+      target: UniProt:P23219
+    - key: negatively regulates
+      source: MESH:D007660
+      target: UniProt:P35354
+    - key: participates in
+      source: UniProt:P23219
+      target: REACT:R-HSA-2162123
+    - key: participates in
+      source: UniProt:P35354
+      target: REACT:R-HSA-2162123
+    - key: increases abundance of
+      source: REACT:R-HSA-2162123
+      target: MESH:D011453
+    - key: positively correlated with
+      source: MESH:D011453
+      target: MESH:D010146
+  multigraph: true
+  nodes:
+    - id: MESH:D007660
+      label: Drug
+      name: ketoprofen
+    - id: UniProt:P23219
+      label: Protein
+      name: Prostaglandin G/H synthase 1
+    - id: UniProt:P35354
+      label: Protein
+      name: Prostaglandin G/H synthase 2
+    - id: REACT:R-HSA-2162123
+      label: Pathway
+      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    - id: MESH:D011453
+      label: ChemicalSubstance
+      name: Prostaglandins
+    - id: MESH:D010146
+      label: Disease
+      name: Pain
+  reference:
+    - https://go.drugbank.com/drugs/DB01009
+    - https://en.wikipedia.org/wiki/Analgesic#COX-2_inhibitors
+- directed: true
+  graph:
+    _id: DB01009_MESH_D004412_1
+    disease: Dysmenorrhea
+    disease_mesh: MESH:D004412
+    drug: ketoprofen
+    drug_mesh: MESH:D007660
+    drugbank: DB:DB01009
+  links:
+    - key: negatively regulates
+      source: MESH:D007660
+      target: UniProt:P23219
+    - key: negatively regulates
+      source: MESH:D007660
+      target: UniProt:P35354
+    - key: participates in
+      source: UniProt:P23219
+      target: REACT:R-HSA-2162123
+    - key: participates in
+      source: UniProt:P35354
+      target: REACT:R-HSA-2162123
+    - key: increases abundance of
+      source: REACT:R-HSA-2162123
+      target: MESH:D011453
+    - key: positively regulates
+      source: MESH:D011453
+      target: MESH:D014590
+    - key: positively correlated with
+      source: MESH:D014590
+      target: MESH:D004412
+  multigraph: true
+  nodes:
+    - id: MESH:D007660
+      label: Drug
+      name: ketoprofen
+    - id: UniProt:P23219
+      label: Protein
+      name: Prostaglandin G/H synthase 1
+    - id: UniProt:P35354
+      label: Protein
+      name: Prostaglandin G/H synthase 2
+    - id: REACT:R-HSA-2162123
+      label: Pathway
+      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    - id: MESH:D011453
+      label: ChemicalSubstance
+      name: Prostaglandins
+    - id: MESH:D014590
+      label: PhenotypicFeature
+      name: Uterine Contraction
+    - id: MESH:D004412
+      label: Disease
+      name: Dysmenorrhea
+  reference:
+    - https://go.drugbank.com/drugs/DB01009
+    - https://www.aafp.org/afp/1999/0801/p489.html
+- directed: true
+  graph:
+    _id: DB00461_MESH_D010003_1
+    disease: Osteoarthritis
+    disease_mesh: MESH:D010003
+    drug: Nabumetone
+    drug_mesh: MESH:D007660
+    drugbank: DB:DB00461
+  links:
+    - key: produces
+      source: MESH:D007660
+      target: CHEBI:35628
+    - key: decreases activity of
+      source: CHEBI:35628
+      target: UniProt:P23219
+    - key: decreases activity of
+      source: CHEBI:35628
+      target: UniProt:P35354
+    - key: participates in
+      source: UniProt:P23219
+      target: REACT:R-HSA-2162123
+    - key: participates in
+      source: UniProt:P35354
+      target: REACT:R-HSA-2162123
+    - key: increases abundance of
+      source: REACT:R-HSA-2162123
+      target: MESH:D011453
+    - key: positively correlated with
+      source: MESH:D011453
+      target: HP:0002829
+    - key: positively correlated with
+      source: MESH:D011453
+      target: HP:0001386
+    - key: positively correlated with
+      source: HP:0001386
+      target: MESH:D010003
+    - key: positively correlated with
+      source: HP:0002829
+      target: MESH:D010003
+  multigraph: true
+  nodes:
+    - id: MESH:D007660
+      label: Drug
+      name: Nabumetone
+    - id: CHEBI:35628
+      label: Drug
+      name: (6-methoxy-2-naphthyl)acetic acid
+    - id: UniProt:P23219
+      label: Protein
+      name: Prostaglandin G/H synthase 1
+    - id: UniProt:P35354
+      label: Protein
+      name: Prostaglandin G/H synthase 2
+    - id: REACT:R-HSA-2162123
+      label: Pathway
+      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    - id: MESH:D011453
+      label: ChemicalSubstance
+      name: Prostaglandins
+    - id: HP:0002829
+      label: PhenotypicFeature
+      name: Joint pain
+    - id: HP:0001386
+      label: PhenotypicFeature
+      name: Joint swelling
+    - id: MESH:D010003
+      label: Disease
+      name: Osteoarthritis
+  reference:
+    - https://go.drugbank.com/drugs/DB00461#mechanism-of-action
+    - https://en.wikipedia.org/wiki/Nabumetone
+  comment: Nabumetone is a prodrug, which is metabolised into the pharmacologically active drug (CHEBI:35628, 6-methoxy-2-naphthyl acetic acid). Note that the drug preferentially blocks COX-2 activity.
+- directed: true
+  graph:
+    _id: DB00712_MESH_D010003_1
+    disease: Osteoarthritis
+    disease_mesh: MESH:D010003
+    drug: flurbiprofen
+    drug_mesh: MESH:D005480
+    drugbank: DB:DB00712
+  links:
+    - key: decreases activity of
+      source: MESH:D005480
+      target: UniProt:P23219
+    - key: decreases activity of
+      source: MESH:D005480
+      target: UniProt:P35354
+    - key: participates in
+      source: UniProt:P23219
+      target: REACT:R-HSA-2162123
+    - key: participates in
+      source: UniProt:P35354
+      target: REACT:R-HSA-2162123
+    - key: increases abundance of
+      source: REACT:R-HSA-2162123
+      target: MESH:D011453
+    - key: positively correlated with
+      source: MESH:D011453
+      target: HP:0002829
+    - key: positively correlated with
+      source: MESH:D011453
+      target: HP:0001386
+    - key: positively correlated with
+      source: HP:0001386
+      target: MESH:D010003
+    - key: positively correlated with
+      source: HP:0002829
+      target: MESH:D010003
+  multigraph: true
+  nodes:
+    - id: MESH:D005480
+      label: Drug
+      name: flurbiprofen
+    - id: UniProt:P23219
+      label: Protein
+      name: Prostaglandin G/H synthase 1
+    - id: UniProt:P35354
+      label: Protein
+      name: Prostaglandin G/H synthase 2
+    - id: REACT:R-HSA-2162123
+      label: Pathway
+      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    - id: MESH:D011453
+      label: ChemicalSubstance
+      name: Prostaglandins
+    - id: HP:0002829
+      label: PhenotypicFeature
+      name: Joint pain
+    - id: HP:0001386
+      label: PhenotypicFeature
+      name: Joint swelling
+    - id: MESH:D010003
+      label: Disease
+      name: Osteoarthritis
+  reference:
+    - https://go.drugbank.com/drugs/DB00712
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL563/
+- directed: true
+  graph:
+    _id: DB00712_MESH_D001172_1
+    disease: Rheumatoid arthritis
+    disease_mesh: MESH:D001172
+    drug: flurbiprofen
+    drug_mesh: MESH:D005480
+    drugbank: DB:DB00712
+  links:
+    - key: decreases activity of
+      source: MESH:D005480
+      target: UniProt:P23219
+    - key: decreases activity of
+      source: MESH:D005480
+      target: UniProt:P35354
+    - key: participates in
+      source: UniProt:P23219
+      target: REACT:R-HSA-2162123
+    - key: participates in
+      source: UniProt:P35354
+      target: REACT:R-HSA-2162123
+    - key: increases abundance of
+      source: REACT:R-HSA-2162123
+      target: MESH:D011453
+    - key: positively correlated with
+      source: MESH:D011453
+      target: HP:0002829
+    - key: positively correlated with
+      source: MESH:D011453
+      target: HP:0001386
+    - key: positively correlated with
+      source: HP:0001386
+      target: MESH:D001172
+    - key: positively correlated with
+      source: HP:0002829
+      target: MESH:D001172
+  multigraph: true
+  nodes:
+    - id: MESH:D005480
+      label: Drug
+      name: flurbiprofen
+    - id: UniProt:P23219
+      label: Protein
+      name: Prostaglandin G/H synthase 1
+    - id: UniProt:P35354
+      label: Protein
+      name: Prostaglandin G/H synthase 2
+    - id: REACT:R-HSA-2162123
+      label: Pathway
+      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    - id: MESH:D011453
+      label: ChemicalSubstance
+      name: Prostaglandins
+    - id: HP:0002829
+      label: PhenotypicFeature
+      name: Joint pain
+    - id: HP:0001386
+      label: PhenotypicFeature
+      name: Joint swelling
+    - id: MESH:D001172
+      label: Disease
+      name: Rheumatoid arthritis
+  reference:
+    - https:// go.drugbank.com/drugs/DB00712
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL563/
+- directed: true
+  graph:
+    _id: DB05219_MESH_D003876_1
+    disease: Atopic dermatitis
+    disease_mesh: MESH:D003876
+    drug: crisaborole
+    drug_mesh: MESH:C543085
+    drugbank: DB:DB05219
+  links:
+    - key: negatively regulates
+      source: MESH:C543085
+      target: UniProt:P27815
+    - key: negatively regulates
+      source: MESH:C543085
+      target: UniProt:Q07343
+    - key: negatively regulates
+      source: MESH:C543085
+      target: UniProt:Q08493
+    - key: negatively regulates
+      source: MESH:C543085
+      target: UniProt:Q08499
+    - key: positively correlated with
+      source: UniProt:P27815
+      target: GO:0006198
+    - key: positively correlated with
+      source: UniProt:Q07343
+      target: GO:0006198
+    - key: positively correlated with
+      source: UniProt:Q08493
+      target: GO:0006198
+    - key: positively correlated with
+      source: UniProt:Q08499
+      target: GO:0006198
+    - key: positively correlated with
+      source: GO:0006198
+      target: GO:0032680
+    - key: positively correlated with
+      source: GO:0006198
+      target: GO:0032674
+    - key: positively correlated with
+      source: GO:0006198
+      target: GO:0032663
+    - key: positively correlated with
+      source: GO:0006198
+      target: GO:0032673
+    - key: positively correlated with
+      source: GO:0006198
+      target: GO:0032649
+    - key: positively correlated with
+      source: GO:0032680
+      target: GO:0006955
+    - key: positively correlated with
+      source: GO:0032674
+      target: GO:0006955
+    - key: positively correlated with
+      source: GO:0032663
+      target: GO:0006955
+    - key: positively correlated with
+      source: GO:0032649
+      target: GO:0006955
+    - key: positively correlated with
+      source: GO:0032673
+      target: GO:0006955
+    - key: positively correlated with
+      source: GO:0032673
+      target: GO:0006954
+    - key: positively correlated with
+      source: GO:0032649
+      target: GO:0006954
+    - key: positively correlated with
+      source: GO:0032663
+      target: GO:0006954
+    - key: positively correlated with
+      source: GO:0032674
+      target: GO:0006954
+    - key: positively correlated with
+      source: GO:0032680
+      target: GO:0006954
+    - key: positively correlated with
+      source: GO:0006955
+      target: MESH:D003876
+    - key: positively correlated with
+      source: GO:0006954
+      target: MESH:D003876
+  multigraph: true
+  nodes:
+    - id: MESH:C543085
+      label: Drug
+      name: crisaborole
+    - id: UniProt:P27815
+      label: Protein
+      name: cAMP-specific 3',5'-cyclic phosphodiesterase 4A
+    - id: UniProt:Q07343
+      label: Protein
+      name: cAMP-specific 3',5'-cyclic phosphodiesterase 4B
+    - id: UniProt:Q08493
+      label: Protein
+      name: cAMP-specific 3',5'-cyclic phosphodiesterase 4C
+    - id: UniProt:Q08499
+      label: Protein
+      name: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
+    - id: GO:0006198
+      label: BiologicalProcess
+      name: cAMP catabolic process
+    - id: GO:0032680
+      label: BiologicalProcess
+      name: regulation of tumor necrosis factor production
+    - id: GO:0032674
+      label: BiologicalProcess
+      name: regulation of interleukin-5 production
+    - id: GO:0032663
+      label: BiologicalProcess
+      name: regulation of interleukin-2 production
+    - id: GO:0032673
+      label: BiologicalProcess
+      name: regulation of interleukin-4 production
+    - id: GO:0032649
+      label: BiologicalProcess
+      name: regulation of interferon-gamma production
+    - id: GO:0006955
+      label: BiologicalProcess
+      name: immune response
+    - id: GO:0006954
+      label: BiologicalProcess
+      name: inflammatory response
+    - id: MESH:D003876
+      label: Disease
+      name: Atopic dermatitis
+  reference:
+    - https://go.drugbank.com/drugs/DB05219#mechanism-of-action
+    - https://en.wikipedia.org/wiki/Crisaborole#Pharmacology
+- directed: true
+  graph:
+    _id: DB00668_MESH_D007022_1
+    disease: Low blood pressure
+    disease_mesh: MESH:D007022
+    drug: epinephrine
+    drug_mesh: MESH:D004837
+    drugbank: DB:DB00668
+  links:
+    - key: increases activity of
+      source: MESH:D004837
+      target: UniProt:P08588
+    - key: participates in
+      source: UniProt:P08588
+      target: REACT:R-HSA-418555
+    - key: positively regulates
+      source: REACT:R-HSA-418555
+      target: GO:0060047
+    - key: positively correlated with
+      source: GO:0060047
+      target: HP:0033533
+    - key: negatively correlated with
+      source: HP:0033533
+      target: MESH:D007022
+  multigraph: true
+  nodes:
+    - id: MESH:D004837
+      label: Drug
+      name: epinephrine
+    - id: UniProt:P08588
+      label: Protein
+      name: Beta-1 adrenergic receptor
+    - id: REACT:R-HSA-418555
+      label: Pathway
+      name: G alpha (s) signalling events
+    - id: GO:0060047
+      label: BiologicalProcess
+      name: heart contraction
+    - id: HP:0033533
+      label: PhenotypicFeature
+      name: Increased cardiac output
+    - id: MESH:D007022
+      label: Disease
+      name: Low blood pressure
+  reference:
+    - https://go.drugbank.com/drugs/DB00668#mechanism-of-action
+    - http://pathwaymedicine.org/Epinephrine
+    - https://en.wikipedia.org/wiki/Beta-1_adrenergic_receptor
+    - https://en.wikipedia.org/wiki/Adrenergic_receptor#History
+- directed: true
+  graph:
+    _id: DB00668_MESH_D004417_1
+    disease: Dyspnea
+    disease_mesh: MESH:D004417
+    drug: epinephrine
+    drug_mesh: MESH:D004837
+    drugbank: DB:DB00668
+  links:
+  - key: positively regulates
+    source: MESH:D004837
+    target: UniProt:P07550
+  - key: negatively regulates
+    source: MESH:D004837
+    target: UniProt:P25100
+  - key: positively regulates
+    source: MESH:D004837
+    target: UniProt:P08588
+  - key: positively regulates
+    source: MESH:D004837
+    target: UniProt:P35368
+  - key: positively regulates
+    source: MESH:D004837
+    target: UniProt:P35348
+  - key: positively regulates
+    source: MESH:D004837
+    target: UniProt:P08913
+  - key: positively regulates
+    source: MESH:D004837
+    target: UniProt:P18089
+  - key: negatively regulates
+    source: UniProt:P07550
+    target: GO:0042310
+  - key: positively regulates
+    source: UniProt:P25100
+    target: GO:0042310
+  - key: negatively regulates
+    source: UniProt:P08588
+    target: GO:0042310
+  - key: negatively regulates
+    source: UniProt:P35368
+    target: GO:0042310
+  - key: negatively regulates
+    source: UniProt:P35348
+    target: GO:0042310
+  - key: negatively regulates
+    source: UniProt:P08913
+    target: GO:0042310
+  - key: negatively regulates
+    source: UniProt:P18089
+    target: GO:0042310
+  - key: located in
+    source: GO:0042310
+    target: UBERON:0000065
+  - key: location of
+    source: UBERON:0000065
+    target: MESH:D004417
+  multigraph: true
+  nodes:
+  - id: MESH:D004837
+    label: Drug
+    name: epinephrine
+  - id: UniProt:P07550
+    label: Protein
+    name: Beta-2 adrenergic receptor
+  - id: UniProt:P35368
+    label: Protein
+    name: Alpha-1B adrenergic receptor
+  - id: UniProt:P35348
+    label: Protein
+    name: Alpha-1A adrenergic receptor
+  - id: UniProt:P08913
+    label: Protein
+    name: Beta-2 adrenergic receptor
+  - id: UniProt:P18089
+    label: Protein
+    name: Alpha-2A adrenergic receptor
+  - id: UniProt:P08588
+    label: Protein
+    name: Beta-1 adrenergic receptor
+  - id: UniProt:P25100
+    label: Protein
+    name: Alpha-1D adrenergic receptor
+  - id: GO:0042310
+    label: BiologicalProcess
+    name: vasoconstriction
+  - id: UBERON:0000065
+    label: GrossAnatomicalStructure
+    name: respiratory tract
+  - id: MESH:D004417
+    label: Disease
+    name: Dyspnea
+  reference:
+    - https://go.drugbank.com/drugs/DB00668#BE0000694
+    - https://en.wikipedia.org/wiki/Shortness_of_breath#Chronic_obstructive_pulmonary_disease
+    - https://en.wikipedia.org/wiki/Beta2-adrenergic_agonist#Mechanism_of_action
+- directed: true
+  graph:
+    _id: DB00668_MESH_D001991_1
+    disease: Bronchitis
+    disease_mesh: MESH:D001991
+    drug: epinephrine
+    drug_mesh: MESH:D004837
+    drugbank: DB:DB00668
+  links:
+  - key: positively regulates
+    source: MESH:D004837
+    target: UniProt:P07550
+  - key: negatively regulates
+    source: MESH:D004837
+    target: UniProt:P25100
+  - key: positively regulates
+    source: MESH:D004837
+    target: UniProt:P08588
+  - key: positively regulates
+    source: MESH:D004837
+    target: UniProt:P35368
+  - key: positively regulates
+    source: MESH:D004837
+    target: UniProt:P35348
+  - key: positively regulates
+    source: MESH:D004837
+    target: UniProt:P08913
+  - key: positively regulates
+    source: MESH:D004837
+    target: UniProt:P18089
+  - key: negatively regulates
+    source: UniProt:P07550
+    target: GO:0042310
+  - key: positively regulates
+    source: UniProt:P25100
+    target: GO:0042310
+  - key: negatively regulates
+    source: UniProt:P08588
+    target: GO:0042310
+  - key: negatively regulates
+    source: UniProt:P35368
+    target: GO:0042310
+  - key: negatively regulates
+    source: UniProt:P35348
+    target: GO:0042310
+  - key: negatively regulates
+    source: UniProt:P08913
+    target: GO:0042310
+  - key: negatively regulates
+    source: UniProt:P18089
+    target: GO:0042310
+  - key: located in
+    source: GO:0042310
+    target: UBERON:0002185
+  - key: location of
+    source: UBERON:0002185
+    target: MESH:D001991
+  multigraph: true
+  nodes:
+  - id: MESH:D004837
+    label: Drug
+    name: epinephrine
+  - id: UniProt:P07550
+    label: Protein
+    name: Beta-2 adrenergic receptor
+  - id: UniProt:P35368
+    label: Protein
+    name: Alpha-1B adrenergic receptor
+  - id: UniProt:P35348
+    label: Protein
+    name: Alpha-1A adrenergic receptor
+  - id: UniProt:P08913
+    label: Protein
+    name: Beta-2 adrenergic receptor
+  - id: UniProt:P18089
+    label: Protein
+    name: Alpha-2A adrenergic receptor
+  - id: UniProt:P08588
+    label: Protein
+    name: Beta-1 adrenergic receptor
+  - id: UniProt:P25100
+    label: Protein
+    name: Alpha-1D adrenergic receptor
+  - id: GO:0042310
+    label: BiologicalProcess
+    name: vasoconstriction
+  - id: UBERON:0002185
+    label: GrossAnatomicalStructure
+    name: bronchus
+  - id: MESH:D001991
+    label: Disease
+    name: Bronchitis
+  reference:
+    - https://go.drugbank.com/drugs/DB00668
+    - https://en.wikipedia.org/wiki/Bronchodilator#Common_bronchodilators
+    - https://en.wikipedia.org/wiki/Bronchitis
+- directed: true
+  graph:
+    _id: DB00668_MESH_D001987_1
+    disease: Bronchiectasis
+    disease_mesh: MESH:D001987
+    drug: epinephrine
+    drug_mesh: MESH:D004837
+    drugbank: DB:DB00668
+  links:
+  - key: positively regulates
+    source: MESH:D004837
+    target: UniProt:P07550
+  - key: negatively regulates
+    source: MESH:D004837
+    target: UniProt:P25100
+  - key: positively regulates
+    source: MESH:D004837
+    target: UniProt:P08588
+  - key: positively regulates
+    source: MESH:D004837
+    target: UniProt:P35368
+  - key: positively regulates
+    source: MESH:D004837
+    target: UniProt:P35348
+  - key: positively regulates
+    source: MESH:D004837
+    target: UniProt:P08913
+  - key: positively regulates
+    source: MESH:D004837
+    target: UniProt:P18089
+  - key: negatively regulates
+    source: UniProt:P07550
+    target: GO:0042310
+  - key: positively regulates
+    source: UniProt:P25100
+    target: GO:0042310
+  - key: negatively regulates
+    source: UniProt:P08588
+    target: GO:0042310
+  - key: negatively regulates
+    source: UniProt:P35368
+    target: GO:0042310
+  - key: negatively regulates
+    source: UniProt:P35348
+    target: GO:0042310
+  - key: negatively regulates
+    source: UniProt:P08913
+    target: GO:0042310
+  - key: negatively regulates
+    source: UniProt:P18089
+    target: GO:0042310
+  - key: located in
+    source: GO:0042310
+    target: UBERON:0001005
+  - key: location of
+    source: UBERON:0001005
+    target: MESH:D001987
+  multigraph: true
+  nodes:
+  - id: MESH:D004837
+    label: Drug
+    name: epinephrine
+  - id: UniProt:P07550
+    label: Protein
+    name: Beta-2 adrenergic receptor
+  - id: UniProt:P35368
+    label: Protein
+    name: Alpha-1B adrenergic receptor
+  - id: UniProt:P35348
+    label: Protein
+    name: Alpha-1A adrenergic receptor
+  - id: UniProt:P08913
+    label: Protein
+    name: Beta-2 adrenergic receptor
+  - id: UniProt:P18089
+    label: Protein
+    name: Alpha-2A adrenergic receptor
+  - id: UniProt:P08588
+    label: Protein
+    name: Beta-1 adrenergic receptor
+  - id: UniProt:P25100
+    label: Protein
+    name: Alpha-1D adrenergic receptor
+  - id: GO:0042310
+    label: BiologicalProcess
+    name: vasoconstriction
+  - id: UBERON:0001005
+    label: GrossAnatomicalStructure
+    name: respiratory airway
+  - id: MESH:D001987
+    label: Disease
+    name: Bronchiectasis
+  reference:
+    - https://go.drugbank.com/drugs/DB00668
+    - https://en.wikipedia.org/wiki/Bronchodilator#Common_bronchodilators
+    - https://en.wikipedia.org/wiki/Adrenaline#Mechanism_of_action
+    - https://en.wikipedia.org/wiki/Bronchiectasis