From 3b1a5e0fce2ea20fa432f95bef961e885c5f9f37 Mon Sep 17 00:00:00 2001 From: AlexT322 Date: Sat, 4 Dec 2021 20:44:30 +0000 Subject: [PATCH] Commit from GitHub Actions (Update Indications on Merge) --- indication_paths.json | 76 +++++++++++++++++++++++++++++++++++++++++++ indication_paths.yaml | 48 +++++++++++++++++++++++++++ submission.yaml | 48 +-------------------------- 3 files changed, 125 insertions(+), 47 deletions(-) diff --git a/indication_paths.json b/indication_paths.json index 9621af018..75f950e60 100644 --- a/indication_paths.json +++ b/indication_paths.json @@ -289429,5 +289429,81 @@ "reference": [ "https://go.drugbank.com/drugs/DB09462" ] + }, + { + "directed": true, + "graph": { + "_id": "DB00715_MESH_D013313_1", + "disease": "Posttraumatic stress disorder", + "disease_mesh": "MESH:D013313", + "drug": "paroxetine", + "drug_mesh": "MESH:D017374", + "drugbank": "DB:DB00715" + }, + "links": [ + { + "key": "decreases activity of", + "source": "MESH:D017374", + "target": "UniProt:P31645" + }, + { + "key": "positively regulates", + "source": "UniProt:P31645", + "target": "GO:0051610" + }, + { + "key": "decreases abundance of", + "source": "GO:0051610", + "target": "MESH:D012701" + }, + { + "key": "positively correlated with", + "source": "MESH:D012701", + "target": "GO:0060096" + }, + { + "key": "negatively correlated with", + "source": "GO:0060096", + "target": "MESH:D013313" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:D017374", + "label": "Drug", + "name": "Paroxetine" + }, + { + "id": "UniProt:P31645", + "label": "Protein", + "name": "Sodium-dependent serotonin transporter" + }, + { + "id": "GO:0051610", + "label": "BiologicalProcess", + "name": "Serotonin uptake" + }, + { + "id": "MESH:D012701", + "label": "ChemicalSubstance", + "name": "Serotonin" + }, + { + "id": "GO:0060096", + "label": "BiologicalProcess", + "name": "Serotonin secretion, neurotransmission" + }, + { + "id": "MESH:D013313", + "label": "Disease", + "name": "Posttraumatic stress disorder" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB00715#BE0000749", + "https://drugs.ncats.io/drug/41VRH5220H", + "https://en.wikipedia.org/wiki/Post-traumatic_stress_disorder" + ] } ] \ No newline at end of file diff --git a/indication_paths.yaml b/indication_paths.yaml index ea7fb5284..cb3b41599 100644 --- a/indication_paths.yaml +++ b/indication_paths.yaml @@ -181937,3 +181937,51 @@ name: Constipation reference: - https://go.drugbank.com/drugs/DB09462 +- directed: true + graph: + _id: DB00715_MESH_D013313_1 + disease: Posttraumatic stress disorder + disease_mesh: MESH:D013313 + drug: paroxetine + drug_mesh: MESH:D017374 + drugbank: DB:DB00715 + links: + - key: decreases activity of + source: MESH:D017374 + target: UniProt:P31645 + - key: positively regulates + source: UniProt:P31645 + target: GO:0051610 + - key: decreases abundance of + source: GO:0051610 + target: MESH:D012701 + - key: positively correlated with + source: MESH:D012701 + target: GO:0060096 + - key: negatively correlated with + source: GO:0060096 + target: MESH:D013313 + multigraph: true + nodes: + - id: MESH:D017374 + label: Drug + name: Paroxetine + - id: UniProt:P31645 + label: Protein + name: Sodium-dependent serotonin transporter + - id: GO:0051610 + label: BiologicalProcess + name: Serotonin uptake + - id: MESH:D012701 + label: ChemicalSubstance + name: Serotonin + - id: GO:0060096 + label: BiologicalProcess + name: Serotonin secretion, neurotransmission + - id: MESH:D013313 + label: Disease + name: Posttraumatic stress disorder + reference: + - https://go.drugbank.com/drugs/DB00715#BE0000749 + - https://drugs.ncats.io/drug/41VRH5220H + - https://en.wikipedia.org/wiki/Post-traumatic_stress_disorder diff --git a/submission.yaml b/submission.yaml index e78e8e344..8b1378917 100644 --- a/submission.yaml +++ b/submission.yaml @@ -1,47 +1 @@ -- directed: true - graph: - disease: Posttraumatic stress disorder - disease_mesh: MESH:D013313 - drug: paroxetine - drug_mesh: MESH:D017374 - drugbank: DB:DB00715 - links: - - key: decreases activity of - source: MESH:D017374 - target: UniProt:P31645 - - key: positively regulates - source: UniProt:P31645 - target: GO:0051610 - - key: decreases abundance of - source: GO:0051610 - target: MESH:D012701 - - key: positively correlated with - source: MESH:D012701 - target: GO:0060096 - - key: negatively correlated with - source: GO:0060096 - target: MESH:D013313 - multigraph: true - nodes: - - id: MESH:D017374 - label: Drug - name: Paroxetine - - id: UniProt:P31645 - label: Protein - name: Sodium-dependent serotonin transporter - - id: GO:0051610 - label: BiologicalProcess - name: Serotonin uptake - - id: MESH:D012701 - label: ChemicalSubstance - name: Serotonin - - id: GO:0060096 - label: BiologicalProcess - name: Serotonin secretion, neurotransmission - - id: MESH:D013313 - label: Disease - name: Posttraumatic stress disorder - reference: - - https://go.drugbank.com/drugs/DB00715#BE0000749 - - https://drugs.ncats.io/drug/41VRH5220H - - https://en.wikipedia.org/wiki/Post-traumatic_stress_disorder +