diff --git a/indication_paths.json b/indication_paths.json
index cc1d48c19..2e8b57779 100644
--- a/indication_paths.json
+++ b/indication_paths.json
@@ -67598,7 +67598,7 @@
       {
         "id": "HP:0005059",
         "label": "PhenotypicFeature",
-        "name": "Joint pain/Joint inflammation"
+        "name": "Arthralgia/arthritis"
       },
       {
         "id": "HP:0001386",
@@ -67646,16 +67646,11 @@
       {
         "key": "positively correlated with",
         "source": "GO:0030593",
-        "target": "MESH:D020556"
-      },
-      {
-        "key": "positively correlated with",
-        "source": "MESH:D020556",
         "target": "HP:0005059"
       },
       {
         "key": "positively correlated with",
-        "source": "MESH:D020556",
+        "source": "GO:0030593",
         "target": "HP:0001386"
       },
       {
@@ -67704,18 +67699,13 @@
       {
         "id": "HP:0005059",
         "label": "PhenotypicFeature",
-        "name": "Joint pain/Joint inflammation"
+        "name": "Arthralgia/arthritis"
       },
       {
         "id": "HP:0001386",
         "label": "PhenotypicFeature",
         "name": "Joint swelling"
       },
-      {
-        "id": "MESH:D020556",
-        "label": "BiologicalProcess",
-        "name": "Neutrophil Infiltration"
-      },
       {
         "id": "GO:0006954",
         "label": "BiologicalProcess",
@@ -67851,11 +67841,11 @@
       {
         "key": "positively regulates",
         "source": "MESH:D011453",
-        "target": "MESH:D014590"
+        "target": "GO:0070471"
       },
       {
         "key": "positively correlated with",
-        "source": "MESH:D014590",
+        "source": "GO:0070471",
         "target": "MESH:D004412"
       }
     ],
@@ -67887,9 +67877,9 @@
         "name": "Prostaglandins"
       },
       {
-        "id": "MESH:D014590",
-        "label": "PhenotypicFeature",
-        "name": "Uterine Contraction"
+        "id": "GO:0070471",
+        "label": "BiologicalProcess",
+        "name": "uterine smooth muscle contraction"
       },
       {
         "id": "MESH:D004412",
@@ -67903,7 +67893,7 @@
     ]
   },
   {
-    "comment": "In contrast to rheumatoid arthritis, in osteoarthritis the joints do not become hot or red (https://en.wikipedia.org/wiki/Osteoarthritis#cite_note-NIH2015-1).",
+    "comment": "In contrast to rheumatoid arthritis, in osteoarthritis the joints do not become hot or red.  (https://en.wikipedia.org/wiki/Osteoarthritis#cite_note-NIH2015-1)",
     "directed": true,
     "graph": {
       "_id": "DB01009_MESH_D010003_1",
@@ -67990,7 +67980,7 @@
       {
         "id": "HP:0002829",
         "label": "PhenotypicFeature",
-        "name": "Joint pain"
+        "name": "Arthralgia"
       },
       {
         "id": "HP:0001386",
@@ -95107,7 +95097,7 @@
       {
         "id": "HP:0002829",
         "label": "PhenotypicFeature",
-        "name": "Joint pain"
+        "name": "Arthralgia"
       },
       {
         "id": "HP:0001386",
@@ -95212,7 +95202,7 @@
       },
       {
         "id": "REACT:R-HSA-2162123",
-        "label": "BiologicalProcess",
+        "label": "Pathway",
         "name": "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"
       },
       {
@@ -95223,7 +95213,7 @@
       {
         "id": "HP:0002829",
         "label": "PhenotypicFeature",
-        "name": "Joint pain"
+        "name": "Arthralgia"
       },
       {
         "id": "HP:0001386",
@@ -123816,7 +123806,7 @@
     ]
   },
   {
-    "comments": "The disease, specially the acute form, is mainly caused by infection (https://en.wikipedia.org/wiki/Enterocolitis#Cause), leading to inflammation. So in addition to treating the symptoms (such as spams and GI secretions), antibiotics, anti-virals etc may be needed for treatment (https://en.wikipedia.org/wiki/Enterocolitis#Treatment).",
+    "comment": "The disease, specially the acute form, is mainly caused by infection (https://en.wikipedia.org/wiki/Enterocolitis#Cause), leading to inflammation. So in addition to treating the symptoms (such as spams and GI secretions), antibiotics, anti-virals etc may be needed for treatment (https://en.wikipedia.org/wiki/Enterocolitis#Treatment).",
     "directed": true,
     "graph": {
       "_id": "DB00771_MESH_D004760_1",
@@ -123840,21 +123830,21 @@
       {
         "key": "positively correlated with",
         "source": "GO:0006939",
-        "target": "MESH:D007419"
+        "target": "GO:0001696"
       },
       {
         "key": "positively correlated with",
         "source": "GO:0006939",
-        "target": "MESH:D013035"
+        "target": "HP:0003394"
       },
       {
-        "key": "manifestation of",
-        "source": "MESH:D007419",
+        "key": "correlated with",
+        "source": "GO:0001696",
         "target": "MESH:D004760"
       },
       {
-        "key": "manifestation of",
-        "source": "MESH:D013035",
+        "key": "correlated with",
+        "source": "HP:0003394",
         "target": "MESH:D004760"
       }
     ],
@@ -123876,14 +123866,14 @@
         "name": "smooth muscle contraction"
       },
       {
-        "id": "MESH:D007419",
+        "id": "GO:0001696",
         "label": "BiologicalProcess",
         "name": "Intestinal Secretions"
       },
       {
-        "id": "MESH:D013035",
-        "label": "BiologicalProcess",
-        "name": "Spasm"
+        "id": "HP:0003394",
+        "label": "PhenotypicFeature",
+        "name": "Muscle spasm"
       },
       {
         "id": "MESH:D004760",
@@ -123983,7 +123973,7 @@
     ]
   },
   {
-    "comments": "In Parkinson's disease, there is imbalance between levels of acetylcholine and dopamine, where increased levels of acetylcholine and degeneration of dopaminergic pathways are observed. Therefore, muscarinic antagonists block central cholinergic activity and balance out neurotransmitters in the brain (https://en.wikipedia.org/wiki/Muscarinic_antagonist#Effects). Anticholinergic drugs may also be prescribed to improve bladder dysfunction (https://pubmed.ncbi.nlm.nih.gov/20370804/).",
+    "comment": "In Parkinson's disease, there is imbalance between levels of acetylcholine and dopamine, where increased levels of acetylcholine and degeneration of dopaminergic pathways are observed. Therefore, muscarinic antagonists block central cholinergic activity and balance out neurotransmitters in the brain (https://en.wikipedia.org/wiki/Muscarinic_antagonist#Effects). Anticholinergic drugs may also be prescribed to improve bladder dysfunction (https://pubmed.ncbi.nlm.nih.gov/20370804/).",
     "directed": true,
     "graph": {
       "_id": "DB00942_MESH_D010300_1",
@@ -124049,7 +124039,7 @@
     ]
   },
   {
-    "comments": "The the antiseizure mechanism of action based on the voltage sodium channels is not a consensus (https://en.wikipedia.org/wiki/Eslicarbazepine_acetate#Mechanism_of_action). The drug could also bind to calcium channels (https://go.drugbank.com/drugs/DB09119#mechanism-of-action). Note that the protein target listed in DrugBank (https://go.drugbank.com/drugs/DB09119#BE0005793) does not seem to be involved in epilepsy, but rather in inflammation and pain.",
+    "comment": "The antiseizure mechanism of action based on the voltage sodium channels is not a consensus (https://en.wikipedia.org/wiki/Eslicarbazepine_acetate#Mechanism_of_action). The drug could also bind to calcium channels (https://go.drugbank.com/drugs/DB09119#mechanism-of-action). Note that the protein target listed in DrugBank (https://go.drugbank.com/drugs/DB09119#BE0005793) does not seem to be involved in epilepsy, but rather in inflammation and pain.",
     "directed": true,
     "graph": {
       "_id": "DB09119_MESH_D004828_1",
@@ -124061,18 +124051,18 @@
     },
     "links": [
       {
-        "key": "produces",
+        "key": "has metabolite",
         "source": "MESH:C416835",
         "target": "MESH:C571001"
       },
       {
         "key": "decreases activity of",
         "source": "MESH:C571001",
-        "target": "MESH:D061566"
+        "target": "InterPro:IPR001696"
       },
       {
         "key": "positively regulates",
-        "source": "MESH:D061566",
+        "source": "InterPro:IPR001696",
         "target": "GO:0035725"
       },
       {
@@ -124104,9 +124094,9 @@
         "name": "eslicarbazepine"
       },
       {
-        "id": "MESH:D061566",
+        "id": "InterPro:IPR001696",
         "label": "GeneFamily",
-        "name": "Voltage-Gated Sodium Channels"
+        "name": "Voltage gated sodium channel, alpha subunit"
       },
       {
         "id": "GO:0035725",
@@ -124135,7 +124125,7 @@
     ]
   },
   {
-    "comments": "This disease is denoted as Disorder of lung in the original file. Note this disease name is a very generic term, that could encompass any diseases of the lungs, including neoplasms, infectious diseases (e.g. tuberculosis) and rare diseases (e.g. cystic fibrosis) for which theophylline may not have any therapeutic benefit at all. Therefore, this annotation is done for all lung diseases that could be indications for this drug to encompass diseases that are similar to asthma, bronchitis, COPD and alike.",
+    "comment": "This disease is also known as Disorder of lung as per DrugCentral. Note this disease name is a very generic term, that could encompass any diseases of the lungs, including neoplasms, infectious diseases (e.g. tuberculosis) and rare diseases (e.g. cystic fibrosis) for which theophylline may not have any therapeutic benefit at all. Therefore, this annotation is done for all lung diseases that could be indications for this drug to encompass diseases that are similar to asthma, bronchitis, COPD and alike.",
     "directed": true,
     "graph": {
       "_id": "DB00277_MESH_D008171_1",
@@ -124164,41 +124154,36 @@
       {
         "key": "decreases activity of",
         "source": "MESH:D013806",
-        "target": "MESH:D015105"
-      },
-      {
-        "key": "decreases activity of",
-        "source": "MESH:D013806",
-        "target": "MESH:D015106"
+        "target": "InterPro:IPR023174"
       },
       {
         "key": "decreases activity of",
         "source": "MESH:D013806",
-        "target": "MESH:D018047"
+        "target": "InterPro:IPR001634"
       },
       {
         "key": "positively regulates",
-        "source": "MESH:D015105",
+        "source": "InterPro:IPR023174",
         "target": "GO:0006198"
       },
       {
         "key": "negatively regulates",
-        "source": "MESH:D015106",
+        "source": "InterPro:IPR023174",
         "target": "GO:0019933"
       },
       {
         "key": "positively regulates",
-        "source": "MESH:D018047",
-        "target": "MESH:D016084"
+        "source": "InterPro:IPR001634",
+        "target": "HP:4000007"
       },
       {
         "key": "positively correlated with",
-        "source": "MESH:D016084",
+        "source": "HP:4000007",
         "target": "MESH:D008171"
       },
       {
         "key": "positively regulates",
-        "source": "MESH:D018047",
+        "source": "InterPro:IPR001634",
         "target": "GO:0006954"
       },
       {
@@ -124244,19 +124229,14 @@
         "name": "theophylline"
       },
       {
-        "id": "MESH:D018047",
-        "label": "GeneFamily",
-        "name": "Receptors, Purinergic P1"
-      },
-      {
-        "id": "MESH:D015106",
+        "id": "InterPro:IPR001634",
         "label": "GeneFamily",
-        "name": "3',5'-Cyclic-GMP Phosphodiesterases"
+        "name": "Adenosine receptor"
       },
       {
-        "id": "MESH:D015105",
+        "id": "InterPro:IPR023174",
         "label": "GeneFamily",
-        "name": "3',5'-Cyclic-AMP Phosphodiesterases"
+        "name": "3'5'-cyclic nucleotide phosphodiesterase, conserved site"
       },
       {
         "id": "UniProt:Q92769",
@@ -124289,8 +124269,8 @@
         "name": "relaxation of smooth muscle"
       },
       {
-        "id": "MESH:D016084",
-        "label": "BiologicalProcess",
+        "id": "HP:4000007",
+        "label": "PhenotypicFeature",
         "name": "Bronchoconstriction"
       },
       {
@@ -124464,7 +124444,7 @@
     ]
   },
   {
-    "comments": "The disease is denoted Carcinoma of breast in the original file as per DrugCentral. The drug intercaltes with DNA and prevents DNA replication and downstream processes, some of them involving UniProt:P11388, which leads to cell/tumour death.",
+    "comment": "The disease is denoted Carcinoma of breast in the original file as per DrugCentral. The drug intercaltes with DNA and prevents DNA replication and downstream processes, some of them involving UniProt:P11388, which leads to cell/tumour death.",
     "directed": true,
     "graph": {
       "_id": "DB00445_MESH_D001943_1",
@@ -124513,11 +124493,11 @@
       {
         "key": "positively correlated with",
         "source": "MESH:D005609",
-        "target": "MESH:D004249"
+        "target": "GO:0090734"
       },
       {
         "key": "positively correlated with",
-        "source": "MESH:D004249",
+        "source": "GO:0090734",
         "target": "GO:0006915"
       },
       {
@@ -124569,9 +124549,9 @@
         "name": "Free Radicals"
       },
       {
-        "id": "MESH:D004249",
-        "label": "BiologicalProcess",
-        "name": "DNA Damage"
+        "id": "GO:0090734",
+        "label": "CellularComponent",
+        "name": "site of DNA damage"
       },
       {
         "id": "GO:0006260",
@@ -124605,7 +124585,7 @@
     ]
   },
   {
-    "comments": "The disease is denoted Deep venous thrombosis in the original file as per DrugCentral. Note that among the original MESH IDs for this drug one of them seems to have been deprecated (MESH:C438268) whereas the other (MESH:C049714) is for a compound where no evidence has been found to be related to fondaparinux.",
+    "comment": "The disease is also known as Deep venous thrombosis as per DrugCentral. Note that among the original MESH IDs for this drug one of them seems to have been deprecated (MESH:C438268) whereas the other (MESH:C049714) is for a compound where no evidence has been found to be related to fondaparinux.",
     "directed": true,
     "graph": {
       "_id": "DB00569_MESH_D020246_1",
@@ -124682,7 +124662,7 @@
     ]
   },
   {
-    "comments": "The disease is denoted Pulmonary thromboembolism in the original file as per DrugCentral. Note that among the original MESH IDs for this drug one of them seems to have been deprecated (MESH:C438268) whereas the other (MESH:C049714) is for a compound where no evidence has been found to be related to fondaparinux.",
+    "comment": "The disease is also known as Pulmonary thromboembolism as per DrugCentral. Note that among the original MESH IDs for this drug one of them seems to have been deprecated (MESH:C438268) whereas the other (MESH:C049714) is for a compound where no evidence has been found to be related to fondaparinux.",
     "directed": true,
     "graph": {
       "_id": "DB00569_MESH_D011655_1",
@@ -130116,7 +130096,7 @@
     ]
   },
   {
-    "comments": "Levomefolic acid can be found in contraceptive pills as a source of folic acid to help to prevent spinal cord birth defects in an unborn baby. We have not found any evidence that levomefolic acid on its own is an indication for acne vulgaris. When combined with hormones such as progestin and estrogen (birth pill) it can be used to treat moderate acne as well as premenstrual dysphoric disorder (https://www.webmd.com/drugs/2/drug-154717/beyaz-oral/details).",
+    "comment": "Levomefolic acid can be found in contraceptive pills as a source of folic acid to help to prevent spinal cord birth defects in an unborn baby. There has not been any evidence to support that levomefolic acid on its own is an indication for acne vulgaris. When combined with hormones such as progestin and estrogen (birth pill) it can be used to treat moderate acne as well as premenstrual dysphoric disorder (https://www.webmd.com/drugs/2/drug-154717/beyaz-oral/details), but not on its own.",
     "directed": true,
     "graph": {
       "_id": "DB11256_MESH_D000152_1",
@@ -130151,7 +130131,7 @@
     ]
   },
   {
-    "comments": "Levomefolic acid can be found in contraceptive pills as a source of folic acid to help to prevent spinal cord birth defects in an unborn baby. We have not found any evidence that levomefolic acid on its own is an indication for Premenstrual dysphoric disorder. When combined with hormones such as progestin and estrogen (birth pill) it can be used to treat premenstrual dysphoric disorder as well as acne (https://www.webmd.com/drugs/2/drug-154717/beyaz-oral/details).",
+    "comment": "Levomefolic acid can be found in contraceptive pills as a source of folic acid to help to prevent spinal cord birth defects in an unborn baby. There has not been any evidence to support that levomefolic acid on its own is an indication for acne vulgaris. When combined with hormones such as progestin and estrogen (birth pill) it can be used to treat moderate acne as well as premenstrual dysphoric disorder (https://www.webmd.com/drugs/2/drug-154717/beyaz-oral/details), but not on its own.",
     "directed": true,
     "graph": {
       "_id": "DB11256_MESH_D065446_1",
@@ -130186,7 +130166,7 @@
     ]
   },
   {
-    "comments": "The drug stimulates the expression of several genes (e.g. HSP, SOD, etc) but it's not clear if the drug binds to these or other targets to modulate the known actions namely oxygen radical scavenging, anti-oxidation, anti-inflammation, and acceleration of gastrointestinal wound healing.",
+    "comment": "The drug stimulates the expression of several genes (e.g. HSP, SOD, etc) but it's not clear if the drug binds to these or other targets to modulate the known actions namely oxygen radical scavenging, anti-oxidation, anti-inflammation, and acceleration of gastrointestinal wound healing.",
     "directed": true,
     "graph": {
       "_id": "DB09221_MESH_D010437_1",
@@ -130198,9 +130178,9 @@
     },
     "links": [
       {
-        "key": "subclass of",
+        "key": "decreases abundance of",
         "source": "MESH:C061957",
-        "target": "MESH:D016166"
+        "target": "CHEBI:26523"
       },
       {
         "key": "positively correlated with",
@@ -130223,9 +130203,9 @@
         "target": "MESH:D010437"
       },
       {
-        "key": "capable of",
+        "key": "positively correlated with",
         "source": "MESH:C061957",
-        "target": "MESH:D014945"
+        "target": "GO:0042060"
       },
       {
         "key": "negatively correlated with",
@@ -130233,23 +130213,18 @@
         "target": "NCBITaxon:210"
       },
       {
-        "key": "positively correlated with",
+        "key": "causes",
         "source": "NCBITaxon:210",
         "target": "MESH:D010437"
       },
       {
-        "key": "located in",
-        "source": "MESH:D014945",
-        "target": "UBERON:0001199"
-      },
-      {
-        "key": "located in",
-        "source": "MESH:D016166",
-        "target": "UBERON:0001199"
+        "key": "negatively correlated with",
+        "source": "GO:0042060",
+        "target": "MESH:D010437"
       },
       {
-        "key": "location of",
-        "source": "UBERON:0001199",
+        "key": "positively correlated with",
+        "source": "CHEBI:26523",
         "target": "MESH:D010437"
       }
     ],
@@ -130261,9 +130236,9 @@
         "name": "polaprezinc"
       },
       {
-        "id": "MESH:D016166",
+        "id": "CHEBI:26523",
         "label": "ChemicalSubstance",
-        "name": "Free Radical Scavengers"
+        "name": "reactive oxygen species"
       },
       {
         "id": "NCBITaxon:210",
@@ -130271,7 +130246,7 @@
         "name": "Helicobacter pylori"
       },
       {
-        "id": "MESH:D014945",
+        "id": "GO:0042060",
         "label": "BiologicalProcess",
         "name": "Wound Healing"
       },
@@ -130285,11 +130260,6 @@
         "label": "BiologicalProcess",
         "name": "mucus secretion"
       },
-      {
-        "id": "UBERON:0001199",
-        "label": "GrossAnatomicalStructure",
-        "name": "mucosa of stomach"
-      },
       {
         "id": "MESH:D010437",
         "label": "Disease",
@@ -130388,7 +130358,7 @@
       {
         "id": "HP:0002829",
         "label": "PhenotypicFeature",
-        "name": "Joint pain"
+        "name": "Arthralgia"
       },
       {
         "id": "HP:0001386",
@@ -130409,7 +130379,7 @@
     ]
   },
   {
-    "comment": "The disease is denoted as Juvenile rheumatoid arthritis as per DrugCentral. Dexibuprofen is an active enantiomer of ibuprofen.",
+    "comment": "The disease is also known as Juvenile rheumatoid arthritis as per DrugCentral. Dexibuprofen is an active enantiomer of ibuprofen.",
     "directed": true,
     "graph": {
       "_id": "DB09213_MESH_D001171_1",
@@ -130496,7 +130466,7 @@
       {
         "id": "HP:0002829",
         "label": "PhenotypicFeature",
-        "name": "Joint pain"
+        "name": "Arthralgia"
       },
       {
         "id": "HP:0001386",
@@ -130604,7 +130574,7 @@
       {
         "id": "HP:0002829",
         "label": "PhenotypicFeature",
-        "name": "Joint pain"
+        "name": "Arthralgia"
       },
       {
         "id": "HP:0001386",
@@ -131420,7 +131390,7 @@
     ]
   },
   {
-    "comments": "The drug enables ribosomes to bypass premature stop codons caused by nonsense mutations in the dystrophin gene. This restores the full-length and functional capability of dystrophin. Without the drug, the premature stop codon means that a truncated protein will be produced, which will be unabled to play its role in muscle strenght and proper function leading to the disease. The disease is denoted Duchenne muscular dystrophy in the original file as per DrugCentral.",
+    "comment": "The drug enables ribosomes to bypass premature stop codons caused by nonsense mutations in the dystrophin gene. This restores the full-length and functional capability of dystrophin. Without the drug, the premature stop codon means that a truncated protein will be produced, which will be unabled to play its role in muscle strenght and proper function leading to the disease. The disease is denoted Duchenne muscular dystrophy in the original file as per DrugCentral.",
     "directed": true,
     "graph": {
       "_id": "DB05016_MESH_D020388_1",
@@ -131437,7 +131407,7 @@
         "target": "UniProt:P11532"
       },
       {
-        "key": "affected by",
+        "key": "disrupted by",
         "source": "UniProt:P11532",
         "target": "MESH:D018389"
       },
@@ -131496,7 +131466,7 @@
     ]
   },
   {
-    "comments": "MESH:C061212 is not an alternative MESH ID for this drug (https://meshb.nlm.nih.gov/record/ui?ui=C061212).",
+    "comment": "MESH:C061212 is not an alternative MESH ID for this drug (https://meshb.nlm.nih.gov/record/ui?ui=C061212).",
     "directed": true,
     "graph": {
       "_id": "DB01057_MESH_D004948_1",
@@ -131597,7 +131567,7 @@
     ]
   },
   {
-    "comments": "The drug allows for the trabecular meshwork in the eye (UBERON:0005969) to open, increasing the outflow of the aqueous humor and having a positive impact on reducing intraocular pressure. Note that MESH:C061212 is not an alternative MESH ID for this drug (https://meshb.nlm.nih.gov/record/ui?ui=C061212). The disease is denoted as Open-angle glaucoma in the original file as per in DrugCentral.",
+    "comment": "The drug allows for the trabecular meshwork in the eye (UBERON:0005969) to open, increasing the outflow of the aqueous humor and having a positive impact on reducing intraocular pressure. Note that MESH:C061212 is not an alternative MESH ID for this drug (https://meshb.nlm.nih.gov/record/ui?ui=C061212). The disease is also known as Open-angle glaucoma as per in DrugCentral.",
     "directed": true,
     "graph": {
       "_id": "DB01057_MESH_D005902_1",
@@ -131718,7 +131688,7 @@
     ]
   },
   {
-    "comments": "The drug allows for the trabecular meshwork in the eye (UBERON:0005969) to open, increasing the outflow of the aqueous humor and having a positive impact on reducing intraocular pressure. Note that MESH:C061212 is not an alternative MESH ID for this drug (https://meshb.nlm.nih.gov/record/ui?ui=C061212).",
+    "comment": "The drug allows for the trabecular meshwork in the eye (UBERON:0005969) to open, increasing the outflow of the aqueous humor and having a positive impact on reducing intraocular pressure. Note that MESH:C061212 is not an alternative MESH ID for this drug (https://meshb.nlm.nih.gov/record/ui?ui=C061212).",
     "directed": true,
     "graph": {
       "_id": "DB01057_MESH_D005901_1",
@@ -131839,7 +131809,7 @@
     ]
   },
   {
-    "comments": "MESH:C061212 is not an alternative MESH ID for this drug (https://meshb.nlm.nih.gov/record/ui?ui=C061212).",
+    "comment": "MESH:C061212 is not an alternative MESH ID for this drug (https://meshb.nlm.nih.gov/record/ui?ui=C061212).",
     "directed": true,
     "graph": {
       "_id": "DB01057_MESH_D000080362_1",
@@ -170920,7 +170890,7 @@
       {
         "id": "HP:0002829",
         "label": "PhenotypicFeature",
-        "name": "Joint pain"
+        "name": "Arthralgia"
       },
       {
         "id": "HP:0001386",
@@ -171025,7 +170995,7 @@
       {
         "id": "HP:0002829",
         "label": "PhenotypicFeature",
-        "name": "Joint pain"
+        "name": "Arthralgia"
       },
       {
         "id": "HP:0001386",
@@ -171039,7 +171009,7 @@
       }
     ],
     "reference": [
-      "https:// go.drugbank.com/drugs/DB00712",
+      "https://go.drugbank.com/drugs/DB00712",
       "https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL563/"
     ]
   },
@@ -205676,7 +205646,7 @@
       },
       {
         "id": "REACT:R-HSA-2162123",
-        "label": "BiologicalProcess",
+        "label": "Pathway",
         "name": "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"
       },
       {
@@ -205687,7 +205657,7 @@
       {
         "id": "HP:0002829",
         "label": "PhenotypicFeature",
-        "name": "Joint pain"
+        "name": "Arthralgia"
       },
       {
         "id": "HP:0001386",
@@ -205791,7 +205761,7 @@
       },
       {
         "id": "REACT:R-HSA-2162123",
-        "label": "BiologicalProcess",
+        "label": "Pathway",
         "name": "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"
       },
       {
@@ -205807,7 +205777,7 @@
       {
         "id": "HP:0002829",
         "label": "PhenotypicFeature",
-        "name": "Joint pain"
+        "name": "Arthralgia"
       },
       {
         "id": "HP:0001386",
@@ -205902,7 +205872,7 @@
       },
       {
         "id": "REACT:R-HSA-2162123",
-        "label": "BiologicalProcess",
+        "label": "Pathway",
         "name": "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"
       },
       {
@@ -205913,7 +205883,7 @@
       {
         "id": "HP:0002829",
         "label": "PhenotypicFeature",
-        "name": "Joint pain"
+        "name": "Arthralgia"
       },
       {
         "id": "HP:0001386",
@@ -206002,7 +205972,7 @@
       },
       {
         "id": "REACT:R-HSA-2162123",
-        "label": "BiologicalProcess",
+        "label": "Pathway",
         "name": "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"
       },
       {
@@ -206612,7 +206582,7 @@
       },
       {
         "id": "REACT:R-HSA-2162123",
-        "label": "BiologicalProcess",
+        "label": "Pathway",
         "name": "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"
       },
       {
@@ -206623,7 +206593,7 @@
       {
         "id": "HP:0002829",
         "label": "PhenotypicFeature",
-        "name": "Joint pain"
+        "name": "Arthralgia"
       },
       {
         "id": "HP:0001386",
@@ -206712,7 +206682,7 @@
       },
       {
         "id": "REACT:R-HSA-2162123",
-        "label": "BiologicalProcess",
+        "label": "Pathway",
         "name": "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"
       },
       {
@@ -206728,7 +206698,7 @@
       {
         "id": "HP:0002829",
         "label": "PhenotypicFeature",
-        "name": "Joint pain"
+        "name": "Arthralgia"
       },
       {
         "id": "HP:0001386",
@@ -206806,7 +206776,7 @@
       },
       {
         "id": "REACT:R-HSA-2162123",
-        "label": "BiologicalProcess",
+        "label": "Pathway",
         "name": "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"
       },
       {
@@ -206817,7 +206787,7 @@
       {
         "id": "HP:0002829",
         "label": "PhenotypicFeature",
-        "name": "Joint pain"
+        "name": "Arthralgia"
       },
       {
         "id": "HP:0001386",
@@ -206969,7 +206939,7 @@
       },
       {
         "id": "REACT:R-HSA-2162123",
-        "label": "BiologicalProcess",
+        "label": "Pathway",
         "name": "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"
       },
       {
@@ -206980,7 +206950,7 @@
       {
         "id": "HP:0002829",
         "label": "PhenotypicFeature",
-        "name": "Joint pain"
+        "name": "Arthralgia"
       },
       {
         "id": "HP:0001386",
@@ -212483,7 +212453,7 @@
       {
         "id": "HP:0002829",
         "label": "PhenotypicFeature",
-        "name": "Joint pain"
+        "name": "Arthralgia"
       },
       {
         "id": "HP:0001386",
diff --git a/indication_paths.yaml b/indication_paths.yaml
index 773d55d0e..0431eee96 100644
--- a/indication_paths.yaml
+++ b/indication_paths.yaml
@@ -42308,7 +42308,7 @@
         name: Prostaglandins
     -   id: HP:0005059
         label: PhenotypicFeature
-        name: Joint pain/Joint inflammation
+        name: Arthralgia/arthritis
     -   id: HP:0001386
         label: PhenotypicFeature
         name: Joint swelling
@@ -42339,12 +42339,9 @@
         target: GO:0002407
     -   key: positively correlated with
         source: GO:0030593
-        target: MESH:D020556
-    -   key: positively correlated with
-        source: MESH:D020556
         target: HP:0005059
     -   key: positively correlated with
-        source: MESH:D020556
+        source: GO:0030593
         target: HP:0001386
     -   key: positively correlated with
         source: GO:0002407
@@ -42374,13 +42371,10 @@
         name: dendritic cell chemotaxis
     -   id: HP:0005059
         label: PhenotypicFeature
-        name: Joint pain/Joint inflammation
+        name: Arthralgia/arthritis
     -   id: HP:0001386
         label: PhenotypicFeature
         name: Joint swelling
-    -   id: MESH:D020556
-        label: BiologicalProcess
-        name: Neutrophil Infiltration
     -   id: GO:0006954
         label: BiologicalProcess
         name: inflammatory response
@@ -42466,9 +42460,9 @@
         target: MESH:D011453
     -   key: positively regulates
         source: MESH:D011453
-        target: MESH:D014590
+        target: GO:0070471
     -   key: positively correlated with
-        source: MESH:D014590
+        source: GO:0070471
         target: MESH:D004412
     multigraph: true
     nodes:
@@ -42487,9 +42481,9 @@
     -   id: MESH:D011453
         label: ChemicalSubstance
         name: Prostaglandins
-    -   id: MESH:D014590
-        label: PhenotypicFeature
-        name: Uterine Contraction
+    -   id: GO:0070471
+        label: BiologicalProcess
+        name: uterine smooth muscle contraction
     -   id: MESH:D004412
         label: Disease
         name: Dysmenorrhea
@@ -42497,7 +42491,7 @@
     - https://go.drugbank.com/drugs/DB01009
     - https://www.aafp.org/afp/1999/0801/p489.html
 -   comment: In contrast to rheumatoid arthritis, in osteoarthritis the joints do
-        not become hot or red (https://en.wikipedia.org/wiki/Osteoarthritis#cite_note-NIH2015-1).
+        not become hot or red.  (https://en.wikipedia.org/wiki/Osteoarthritis#cite_note-NIH2015-1)
     directed: true
     graph:
         _id: DB01009_MESH_D010003_1
@@ -42553,7 +42547,7 @@
         name: Prostaglandins
     -   id: HP:0002829
         label: PhenotypicFeature
-        name: Joint pain
+        name: Arthralgia
     -   id: HP:0001386
         label: PhenotypicFeature
         name: Joint swelling
@@ -59712,7 +59706,7 @@
         name: Prostaglandins
     -   id: HP:0002829
         label: PhenotypicFeature
-        name: Joint pain
+        name: Arthralgia
     -   id: HP:0001386
         label: PhenotypicFeature
         name: Joint swelling
@@ -59779,14 +59773,14 @@
         label: Protein
         name: Prostaglandin G/H synthase 2
     -   id: REACT:R-HSA-2162123
-        label: BiologicalProcess
+        label: Pathway
         name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
     -   id: MESH:D011453
         label: ChemicalSubstance
         name: Prostaglandins
     -   id: HP:0002829
         label: PhenotypicFeature
-        name: Joint pain
+        name: Arthralgia
     -   id: HP:0001386
         label: PhenotypicFeature
         name: Joint swelling
@@ -77865,7 +77859,7 @@
     - https://en.wikipedia.org/wiki/Dofetilide#Mechanism_of_action
     - https://www.cvpharmacology.com/antiarrhy/potassium-blockers
     - https://pubmed.ncbi.nlm.nih.gov/10907968/
--   comments: The disease, specially the acute form, is mainly caused by infection
+-   comment: The disease, specially the acute form, is mainly caused by infection
         (https://en.wikipedia.org/wiki/Enterocolitis#Cause), leading to inflammation.
         So in addition to treating the symptoms (such as spams and GI secretions),
         antibiotics, anti-virals etc may be needed for treatment (https://en.wikipedia.org/wiki/Enterocolitis#Treatment).
@@ -77886,15 +77880,15 @@
         target: GO:0006939
     -   key: positively correlated with
         source: GO:0006939
-        target: MESH:D007419
+        target: GO:0001696
     -   key: positively correlated with
         source: GO:0006939
-        target: MESH:D013035
-    -   key: manifestation of
-        source: MESH:D007419
+        target: HP:0003394
+    -   key: correlated with
+        source: GO:0001696
         target: MESH:D004760
-    -   key: manifestation of
-        source: MESH:D013035
+    -   key: correlated with
+        source: HP:0003394
         target: MESH:D004760
     multigraph: true
     nodes:
@@ -77907,12 +77901,12 @@
     -   id: GO:0006939
         label: BiologicalProcess
         name: smooth muscle contraction
-    -   id: MESH:D007419
+    -   id: GO:0001696
         label: BiologicalProcess
         name: Intestinal Secretions
-    -   id: MESH:D013035
-        label: BiologicalProcess
-        name: Spasm
+    -   id: HP:0003394
+        label: PhenotypicFeature
+        name: Muscle spasm
     -   id: MESH:D004760
         label: Disease
         name: Enterocolitis
@@ -77973,7 +77967,7 @@
     - https://go.drugbank.com/drugs/DB00771#mechanism-of-action
     - https://en.wikipedia.org/wiki/Clidinium_bromide#Mechanism_of_action
     - https://en.wikipedia.org/wiki/Irritable_bowel_syndrome#Medication
--   comments: In Parkinson's disease, there is imbalance between levels of acetylcholine
+-   comment: In Parkinson's disease, there is imbalance between levels of acetylcholine
         and dopamine, where increased levels of acetylcholine and degeneration of
         dopaminergic pathways are observed. Therefore, muscarinic antagonists block
         central cholinergic activity and balance out neurotransmitters in the brain
@@ -78020,8 +78014,8 @@
     reference:
     - https://go.drugbank.com/drugs/DB00942#mechanism-of-action
     - https://pubchem.ncbi.nlm.nih.gov/compound/2911#section=Pharmacology-and-Biochemistry
--   comments: The the antiseizure mechanism of action based on the voltage sodium
-        channels is not a consensus (https://en.wikipedia.org/wiki/Eslicarbazepine_acetate#Mechanism_of_action).
+-   comment: The antiseizure mechanism of action based on the voltage sodium channels
+        is not a consensus (https://en.wikipedia.org/wiki/Eslicarbazepine_acetate#Mechanism_of_action).
         The drug could also bind to calcium channels (https://go.drugbank.com/drugs/DB09119#mechanism-of-action).
         Note that the protein target listed in DrugBank (https://go.drugbank.com/drugs/DB09119#BE0005793)
         does not seem to be involved in epilepsy, but rather in inflammation and pain.
@@ -78034,14 +78028,14 @@
         drug_mesh: MESH:C416835
         drugbank: DB:DB09119
     links:
-    -   key: produces
+    -   key: has metabolite
         source: MESH:C416835
         target: MESH:C571001
     -   key: decreases activity of
         source: MESH:C571001
-        target: MESH:D061566
+        target: InterPro:IPR001696
     -   key: positively regulates
-        source: MESH:D061566
+        source: InterPro:IPR001696
         target: GO:0035725
     -   key: regulates
         source: GO:0035725
@@ -78060,9 +78054,9 @@
     -   id: MESH:C571001
         label: Drug
         name: eslicarbazepine
-    -   id: MESH:D061566
+    -   id: InterPro:IPR001696
         label: GeneFamily
-        name: Voltage-Gated Sodium Channels
+        name: Voltage gated sodium channel, alpha subunit
     -   id: GO:0035725
         label: BiologicalProcess
         name: sodium ion transmembrane transport
@@ -78078,7 +78072,7 @@
     reference:
     - https://pubchem.ncbi.nlm.nih.gov/compound/179344#section=Pharmacology-and-Biochemistry
     - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL87992/
--   comments: This disease is denoted as Disorder of lung in the original file. Note
+-   comment: This disease is also known as Disorder of lung as per DrugCentral. Note
         this disease name is a very generic term, that could encompass any diseases
         of the lungs, including neoplasms, infectious diseases (e.g. tuberculosis)
         and rare diseases (e.g. cystic fibrosis) for which theophylline may not have
@@ -78105,27 +78099,24 @@
         target: GO:0006954
     -   key: decreases activity of
         source: MESH:D013806
-        target: MESH:D015105
-    -   key: decreases activity of
-        source: MESH:D013806
-        target: MESH:D015106
+        target: InterPro:IPR023174
     -   key: decreases activity of
         source: MESH:D013806
-        target: MESH:D018047
+        target: InterPro:IPR001634
     -   key: positively regulates
-        source: MESH:D015105
+        source: InterPro:IPR023174
         target: GO:0006198
     -   key: negatively regulates
-        source: MESH:D015106
+        source: InterPro:IPR023174
         target: GO:0019933
     -   key: positively regulates
-        source: MESH:D018047
-        target: MESH:D016084
+        source: InterPro:IPR001634
+        target: HP:4000007
     -   key: positively correlated with
-        source: MESH:D016084
+        source: HP:4000007
         target: MESH:D008171
     -   key: positively regulates
-        source: MESH:D018047
+        source: InterPro:IPR001634
         target: GO:0006954
     -   key: decreases abundance of
         source: GO:0006198
@@ -78153,15 +78144,12 @@
         id: MESH:D013806
         label: Drug
         name: theophylline
-    -   id: MESH:D018047
-        label: GeneFamily
-        name: Receptors, Purinergic P1
-    -   id: MESH:D015106
+    -   id: InterPro:IPR001634
         label: GeneFamily
-        name: 3',5'-Cyclic-GMP Phosphodiesterases
-    -   id: MESH:D015105
+        name: Adenosine receptor
+    -   id: InterPro:IPR023174
         label: GeneFamily
-        name: 3',5'-Cyclic-AMP Phosphodiesterases
+        name: 3'5'-cyclic nucleotide phosphodiesterase, conserved site
     -   id: UniProt:Q92769
         label: Protein
         name: Histone deacetylase 2
@@ -78180,8 +78168,8 @@
     -   id: GO:0044557
         label: BiologicalProcess
         name: relaxation of smooth muscle
-    -   id: MESH:D016084
-        label: BiologicalProcess
+    -   id: HP:4000007
+        label: PhenotypicFeature
         name: Bronchoconstriction
     -   id: CHEBI:17489
         label: ChemicalSubstance
@@ -78290,7 +78278,7 @@
     reference:
     - https://go.drugbank.com/drugs/DB00046#mechanism-of-action
     - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201538/
--   comments: The disease is denoted Carcinoma of breast in the original file as per
+-   comment: The disease is denoted Carcinoma of breast in the original file as per
         DrugCentral. The drug intercaltes with DNA and prevents DNA replication and
         downstream processes, some of them involving UniProt:P11388, which leads to
         cell/tumour death.
@@ -78326,9 +78314,9 @@
         target: MESH:D005609
     -   key: positively correlated with
         source: MESH:D005609
-        target: MESH:D004249
+        target: GO:0090734
     -   key: positively correlated with
-        source: MESH:D004249
+        source: GO:0090734
         target: GO:0006915
     -   key: negatively correlated with
         source: GO:0006915
@@ -78359,9 +78347,9 @@
     -   id: MESH:D005609
         label: ChemicalSubstance
         name: Free Radicals
-    -   id: MESH:D004249
-        label: BiologicalProcess
-        name: DNA Damage
+    -   id: GO:0090734
+        label: CellularComponent
+        name: site of DNA damage
     -   id: GO:0006260
         label: BiologicalProcess
         name: DNA replication
@@ -78380,10 +78368,10 @@
     reference:
     - https://go.drugbank.com/drugs/DB00445#mechanism-of-action
     - https://en.wikipedia.org/wiki/Epirubicin
--   comments: The disease is denoted Deep venous thrombosis in the original file as
-        per DrugCentral. Note that among the original MESH IDs for this drug one of
-        them seems to have been deprecated (MESH:C438268) whereas the other (MESH:C049714)
-        is for a compound where no evidence has been found to be related to fondaparinux.
+-   comment: The disease is also known as Deep venous thrombosis as per DrugCentral.
+        Note that among the original MESH IDs for this drug one of them seems to have
+        been deprecated (MESH:C438268) whereas the other (MESH:C049714) is for a compound
+        where no evidence has been found to be related to fondaparinux.
     directed: true
     graph:
         _id: DB00569_MESH_D020246_1
@@ -78432,10 +78420,10 @@
     - https://go.drugbank.com/drugs/DB00569#BE0000280
     - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201202/
     - https://en.wikipedia.org/wiki/Fondaparinux#Mechanism_of_action
--   comments: The disease is denoted Pulmonary thromboembolism in the original file
-        as per DrugCentral. Note that among the original MESH IDs for this drug one
-        of them seems to have been deprecated (MESH:C438268) whereas the other (MESH:C049714)
-        is for a compound where no evidence has been found to be related to fondaparinux.
+-   comment: The disease is also known as Pulmonary thromboembolism as per DrugCentral.
+        Note that among the original MESH IDs for this drug one of them seems to have
+        been deprecated (MESH:C438268) whereas the other (MESH:C049714) is for a compound
+        where no evidence has been found to be related to fondaparinux.
     directed: true
     graph:
         _id: DB00569_MESH_D011655_1
@@ -81829,12 +81817,13 @@
     reference:
     - https://en.wikipedia.org/wiki/Piribedil
     - https://en.wikipedia.org/wiki/Parkinsonism
--   comments: Levomefolic acid can be found in contraceptive pills as a source of
-        folic acid to help to prevent spinal cord birth defects in an unborn baby.
-        We have not found any evidence that levomefolic acid on its own is an indication
-        for acne vulgaris. When combined with hormones such as progestin and estrogen
-        (birth pill) it can be used to treat moderate acne as well as premenstrual
-        dysphoric disorder (https://www.webmd.com/drugs/2/drug-154717/beyaz-oral/details).
+-   comment: Levomefolic acid can be found in contraceptive pills as a source of folic
+        acid to help to prevent spinal cord birth defects in an unborn baby. There
+        has not been any evidence to support that levomefolic acid on its own is an
+        indication for acne vulgaris. When combined with hormones such as progestin
+        and estrogen (birth pill) it can be used to treat moderate acne as well as
+        premenstrual dysphoric disorder (https://www.webmd.com/drugs/2/drug-154717/beyaz-oral/details),
+        but not on its own.
     directed: true
     graph:
         _id: DB11256_MESH_D000152_1
@@ -81857,12 +81846,13 @@
         name: Acne vulgaris
     reference:
     - https://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/022532Orig1s000CrossR.pdf
--   comments: Levomefolic acid can be found in contraceptive pills as a source of
-        folic acid to help to prevent spinal cord birth defects in an unborn baby.
-        We have not found any evidence that levomefolic acid on its own is an indication
-        for Premenstrual dysphoric disorder. When combined with hormones such as progestin
-        and estrogen (birth pill) it can be used to treat premenstrual dysphoric disorder
-        as well as acne (https://www.webmd.com/drugs/2/drug-154717/beyaz-oral/details).
+-   comment: Levomefolic acid can be found in contraceptive pills as a source of folic
+        acid to help to prevent spinal cord birth defects in an unborn baby. There
+        has not been any evidence to support that levomefolic acid on its own is an
+        indication for acne vulgaris. When combined with hormones such as progestin
+        and estrogen (birth pill) it can be used to treat moderate acne as well as
+        premenstrual dysphoric disorder (https://www.webmd.com/drugs/2/drug-154717/beyaz-oral/details),
+        but not on its own.
     directed: true
     graph:
         _id: DB11256_MESH_D065446_1
@@ -81885,8 +81875,8 @@
         name: Premenstrual dysphoric disorder
     reference:
     - https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=58cd12d3-39b1-4375-b7e0-09ba2378a52b
--   comments: The drug stimulates the expression of several genes (e.g. HSP, SOD,
-        etc) but it's not clear if the drug binds to these or other targets to modulate
+-   comment: The drug stimulates the expression of several genes (e.g. HSP, SOD, etc)
+        but it's not clear if the drug binds to these or other targets to modulate
         the known actions namely oxygen radical scavenging, anti-oxidation, anti-inflammation,
         and acceleration of gastrointestinal wound healing.
     directed: true
@@ -81898,9 +81888,9 @@
         drug_mesh: MESH:C061957
         drugbank: DB:DB09221
     links:
-    -   key: subclass of
+    -   key: decreases abundance of
         source: MESH:C061957
-        target: MESH:D016166
+        target: CHEBI:26523
     -   key: positively correlated with
         source: MESH:C061957
         target: GO:0070254
@@ -81913,36 +81903,33 @@
     -   key: negatively correlated with
         source: GO:0070254
         target: MESH:D010437
-    -   key: capable of
+    -   key: positively correlated with
         source: MESH:C061957
-        target: MESH:D014945
+        target: GO:0042060
     -   key: negatively correlated with
         source: MESH:C061957
         target: NCBITaxon:210
-    -   key: positively correlated with
+    -   key: causes
         source: NCBITaxon:210
         target: MESH:D010437
-    -   key: located in
-        source: MESH:D014945
-        target: UBERON:0001199
-    -   key: located in
-        source: MESH:D016166
-        target: UBERON:0001199
-    -   key: location of
-        source: UBERON:0001199
+    -   key: negatively correlated with
+        source: GO:0042060
+        target: MESH:D010437
+    -   key: positively correlated with
+        source: CHEBI:26523
         target: MESH:D010437
     multigraph: true
     nodes:
     -   id: MESH:C061957
         label: Drug
         name: polaprezinc
-    -   id: MESH:D016166
+    -   id: CHEBI:26523
         label: ChemicalSubstance
-        name: Free Radical Scavengers
+        name: reactive oxygen species
     -   id: NCBITaxon:210
         label: OrganismTaxon
         name: Helicobacter pylori
-    -   id: MESH:D014945
+    -   id: GO:0042060
         label: BiologicalProcess
         name: Wound Healing
     -   id: GO:0006954
@@ -81951,9 +81938,6 @@
     -   id: GO:0070254
         label: BiologicalProcess
         name: mucus secretion
-    -   id: UBERON:0001199
-        label: GrossAnatomicalStructure
-        name: mucosa of stomach
     -   id: MESH:D010437
         label: Disease
         name: Peptic ulcer
@@ -82015,7 +81999,7 @@
         name: Prostaglandins
     -   id: HP:0002829
         label: PhenotypicFeature
-        name: Joint pain
+        name: Arthralgia
     -   id: HP:0001386
         label: PhenotypicFeature
         name: Joint swelling
@@ -82027,7 +82011,7 @@
     - https://go.drugbank.com/drugs/DB09213#BE0000017
     - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL175/
     - https://en.wikipedia.org/wiki/Ibuprofen#Pharmacology
--   comment: The disease is denoted as Juvenile rheumatoid arthritis as per DrugCentral.
+-   comment: The disease is also known as Juvenile rheumatoid arthritis as per DrugCentral.
         Dexibuprofen is an active enantiomer of ibuprofen.
     directed: true
     graph:
@@ -82084,7 +82068,7 @@
         name: Prostaglandins
     -   id: HP:0002829
         label: PhenotypicFeature
-        name: Joint pain
+        name: Arthralgia
     -   id: HP:0001386
         label: PhenotypicFeature
         name: Joint swelling
@@ -82152,7 +82136,7 @@
         name: Prostaglandins
     -   id: HP:0002829
         label: PhenotypicFeature
-        name: Joint pain
+        name: Arthralgia
     -   id: HP:0001386
         label: PhenotypicFeature
         name: Joint swelling
@@ -82667,7 +82651,7 @@
     - https://go.drugbank.com/drugs/DB06401#mechanism-of-action
     - https://en.wikipedia.org/wiki/Bazedoxifene#Pharmacology
     - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL46740/
--   comments: The drug enables ribosomes to bypass premature stop codons caused by
+-   comment: The drug enables ribosomes to bypass premature stop codons caused by
         nonsense mutations in the dystrophin gene. This restores the full-length and
         functional capability of dystrophin. Without the drug, the premature stop
         codon means that a truncated protein will be produced, which will be unabled
@@ -82686,7 +82670,7 @@
     -   key: positively correlated with
         source: MESH:C515878
         target: UniProt:P11532
-    -   key: affected by
+    -   key: disrupted by
         source: UniProt:P11532
         target: MESH:D018389
     -   key: predisposes
@@ -82721,7 +82705,7 @@
     reference:
     - https://go.drugbank.com/drugs/DB05016#mechanism-of-action
     - https://en.wikipedia.org/wiki/Ataluren#Pharmacology
--   comments: MESH:C061212 is not an alternative MESH ID for this drug (https://meshb.nlm.nih.gov/record/ui?ui=C061212).
+-   comment: MESH:C061212 is not an alternative MESH ID for this drug (https://meshb.nlm.nih.gov/record/ui?ui=C061212).
     directed: true
     graph:
         _id: DB01057_MESH_D004948_1
@@ -82784,12 +82768,11 @@
     reference:
     - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201341/
     - https://go.drugbank.com/drugs/DB01057#BE0002180
--   comments: The drug allows for the trabecular meshwork in the eye (UBERON:0005969)
+-   comment: The drug allows for the trabecular meshwork in the eye (UBERON:0005969)
         to open, increasing the outflow of the aqueous humor and having a positive
         impact on reducing intraocular pressure. Note that MESH:C061212 is not an
         alternative MESH ID for this drug (https://meshb.nlm.nih.gov/record/ui?ui=C061212).
-        The disease is denoted as Open-angle glaucoma in the original file as per
-        in DrugCentral.
+        The disease is also known as Open-angle glaucoma as per in DrugCentral.
     directed: true
     graph:
         _id: DB01057_MESH_D005902_1
@@ -82864,7 +82847,7 @@
     reference:
     - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201341/
     - https://go.drugbank.com/drugs/DB01057#BE0002180
--   comments: The drug allows for the trabecular meshwork in the eye (UBERON:0005969)
+-   comment: The drug allows for the trabecular meshwork in the eye (UBERON:0005969)
         to open, increasing the outflow of the aqueous humor and having a positive
         impact on reducing intraocular pressure. Note that MESH:C061212 is not an
         alternative MESH ID for this drug (https://meshb.nlm.nih.gov/record/ui?ui=C061212).
@@ -82942,7 +82925,7 @@
     reference:
     - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201341/
     - https://go.drugbank.com/drugs/DB01057#BE0002180
--   comments: MESH:C061212 is not an alternative MESH ID for this drug (https://meshb.nlm.nih.gov/record/ui?ui=C061212).
+-   comment: MESH:C061212 is not an alternative MESH ID for this drug (https://meshb.nlm.nih.gov/record/ui?ui=C061212).
     directed: true
     graph:
         _id: DB01057_MESH_D000080362_1
@@ -107446,7 +107429,7 @@
         name: Prostaglandins
     -   id: HP:0002829
         label: PhenotypicFeature
-        name: Joint pain
+        name: Arthralgia
     -   id: HP:0001386
         label: PhenotypicFeature
         name: Joint swelling
@@ -107511,7 +107494,7 @@
         name: Prostaglandins
     -   id: HP:0002829
         label: PhenotypicFeature
-        name: Joint pain
+        name: Arthralgia
     -   id: HP:0001386
         label: PhenotypicFeature
         name: Joint swelling
@@ -107519,7 +107502,7 @@
         label: Disease
         name: Rheumatoid arthritis
     reference:
-    - https:// go.drugbank.com/drugs/DB00712
+    - https://go.drugbank.com/drugs/DB00712
     - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL563/
 -   directed: true
     graph:
@@ -129312,14 +129295,14 @@
         label: Protein
         name: Prostaglandin G/H synthase 2
     -   id: REACT:R-HSA-2162123
-        label: BiologicalProcess
+        label: Pathway
         name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
     -   id: MESH:D011453
         label: ChemicalSubstance
         name: Prostaglandins
     -   id: HP:0002829
         label: PhenotypicFeature
-        name: Joint pain
+        name: Arthralgia
     -   id: HP:0001386
         label: PhenotypicFeature
         name: Joint swelling
@@ -129383,7 +129366,7 @@
         label: Protein
         name: Prostaglandin G/H synthase 2
     -   id: REACT:R-HSA-2162123
-        label: BiologicalProcess
+        label: Pathway
         name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
     -   id: MESH:D011453
         label: ChemicalSubstance
@@ -129393,7 +129376,7 @@
         name: Arthritis
     -   id: HP:0002829
         label: PhenotypicFeature
-        name: Joint pain
+        name: Arthralgia
     -   id: HP:0001386
         label: PhenotypicFeature
         name: Joint swelling
@@ -129452,14 +129435,14 @@
         label: Protein
         name: Prostaglandin G/H synthase 2
     -   id: REACT:R-HSA-2162123
-        label: BiologicalProcess
+        label: Pathway
         name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
     -   id: MESH:D011453
         label: ChemicalSubstance
         name: Prostaglandins
     -   id: HP:0002829
         label: PhenotypicFeature
-        name: Joint pain
+        name: Arthralgia
     -   id: HP:0001386
         label: PhenotypicFeature
         name: Joint swelling
@@ -129514,7 +129497,7 @@
         label: Protein
         name: Prostaglandin G/H synthase 2
     -   id: REACT:R-HSA-2162123
-        label: BiologicalProcess
+        label: Pathway
         name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
     -   id: MESH:D011453
         label: ChemicalSubstance
@@ -129901,14 +129884,14 @@
         label: Protein
         name: Prostaglandin G/H synthase 2
     -   id: REACT:R-HSA-2162123
-        label: BiologicalProcess
+        label: Pathway
         name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
     -   id: MESH:D011453
         label: ChemicalSubstance
         name: Prostaglandins
     -   id: HP:0002829
         label: PhenotypicFeature
-        name: Joint pain
+        name: Arthralgia
     -   id: HP:0001386
         label: PhenotypicFeature
         name: Joint swelling
@@ -129963,7 +129946,7 @@
         label: Protein
         name: Prostaglandin G/H synthase 2
     -   id: REACT:R-HSA-2162123
-        label: BiologicalProcess
+        label: Pathway
         name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
     -   id: MESH:D011453
         label: ChemicalSubstance
@@ -129973,7 +129956,7 @@
         name: Arthritis
     -   id: HP:0002829
         label: PhenotypicFeature
-        name: Joint pain
+        name: Arthralgia
     -   id: HP:0001386
         label: PhenotypicFeature
         name: Joint swelling
@@ -130021,14 +130004,14 @@
         label: Protein
         name: Prostaglandin G/H synthase 2
     -   id: REACT:R-HSA-2162123
-        label: BiologicalProcess
+        label: Pathway
         name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
     -   id: MESH:D011453
         label: ChemicalSubstance
         name: Prostaglandins
     -   id: HP:0002829
         label: PhenotypicFeature
-        name: Joint pain
+        name: Arthralgia
     -   id: HP:0001386
         label: PhenotypicFeature
         name: Joint swelling
@@ -130122,14 +130105,14 @@
         label: Protein
         name: Prostaglandin G/H synthase 2
     -   id: REACT:R-HSA-2162123
-        label: BiologicalProcess
+        label: Pathway
         name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
     -   id: MESH:D011453
         label: ChemicalSubstance
         name: Prostaglandins
     -   id: HP:0002829
         label: PhenotypicFeature
-        name: Joint pain
+        name: Arthralgia
     -   id: HP:0001386
         label: PhenotypicFeature
         name: Joint swelling
@@ -133587,7 +133570,7 @@
         name: Prostaglandins
     -   id: HP:0002829
         label: PhenotypicFeature
-        name: Joint pain
+        name: Arthralgia
     -   id: HP:0001386
         label: PhenotypicFeature
         name: Joint swelling
diff --git a/submission.yaml b/submission.yaml
index 0c293280e..8b1378917 100644
--- a/submission.yaml
+++ b/submission.yaml
@@ -1,2381 +1 @@
-- directed: true
-  graph:
-    _id: DB00712_MESH_D010003_1
-    disease: Osteoarthritis
-    disease_mesh: MESH:D010003
-    drug: flurbiprofen
-    drug_mesh: MESH:D005480
-    drugbank: DB:DB00712
-  links:
-    - key: decreases activity of
-      source: MESH:D005480
-      target: UniProt:P23219
-    - key: decreases activity of
-      source: MESH:D005480
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0002829
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0001386
-    - key: positively correlated with
-      source: HP:0001386
-      target: MESH:D010003
-    - key: positively correlated with
-      source: HP:0002829
-      target: MESH:D010003
-  multigraph: true
-  nodes:
-    - id: MESH:D005480
-      label: Drug
-      name: flurbiprofen
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: HP:0002829
-      label: PhenotypicFeature
-      name: Arthralgia
-    - id: HP:0001386
-      label: PhenotypicFeature
-      name: Joint swelling
-    - id: MESH:D010003
-      label: Disease
-      name: Osteoarthritis
-  reference:
-    - https://go.drugbank.com/drugs/DB00712
-    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL563/
-- directed: true
-  graph:
-    _id: DB00712_MESH_D001172_1
-    disease: Rheumatoid arthritis
-    disease_mesh: MESH:D001172
-    drug: flurbiprofen
-    drug_mesh: MESH:D005480
-    drugbank: DB:DB00712
-  links:
-    - key: decreases activity of
-      source: MESH:D005480
-      target: UniProt:P23219
-    - key: decreases activity of
-      source: MESH:D005480
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0002829
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0001386
-    - key: positively correlated with
-      source: HP:0001386
-      target: MESH:D001172
-    - key: positively correlated with
-      source: HP:0002829
-      target: MESH:D001172
-  multigraph: true
-  nodes:
-    - id: MESH:D005480
-      label: Drug
-      name: flurbiprofen
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: HP:0002829
-      label: PhenotypicFeature
-      name: Arthralgia
-    - id: HP:0001386
-      label: PhenotypicFeature
-      name: Joint swelling
-    - id: MESH:D001172
-      label: Disease
-      name: Rheumatoid arthritis
-  reference: https://go.drugbank.com/drugs/DB00712 https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL563/
-- directed: true
-  graph:
-    _id: DB01009_MESH_D001172_1
-    disease: Rheumatoid arthritis
-    disease_mesh: MESH:D001172
-    drug: ketoprofen
-    drug_mesh: MESH:D007660
-    drugbank: DB:DB01009
-  links:
-    - key: negatively regulates
-      source: MESH:D007660
-      target: UniProt:P23219
-    - key: negatively regulates
-      source: MESH:D007660
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0005059
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0001386
-    - key: positively correlated with
-      source: HP:0001386
-      target: MESH:D001172
-    - key: positively correlated with
-      source: HP:0005059
-      target: MESH:D001172
-  multigraph: true
-  nodes:
-    - id: MESH:D007660
-      label: Drug
-      name: ketoprofen
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: HP:0005059
-      label: PhenotypicFeature
-      name: Arthralgia/arthritis
-    - id: HP:0001386
-      label: PhenotypicFeature
-      name: Joint swelling
-    - id: MESH:D001172
-      label: Disease
-      name: Rheumatoid arthritis
-  reference:
-    - https://go.drugbank.com/drugs/DB01009#mechanism-of-action
-    - https://en.wikipedia.org/wiki/Ketoprofen#Mechanism
-    - https://en.wikipedia.org/wiki/Rheumatoid_arthritis#Anti-inflammatory_and_analgesic_agents
-- directed: true
-  graph:
-    _id: DB01009_MESH_D001172_2
-    disease: Rheumatoid arthritis
-    disease_mesh: MESH:D001172
-    drug: ketoprofen
-    drug_mesh: MESH:D007660
-    drugbank: DB:DB01009
-  links:
-    - key: negatively regulates
-      source: MESH:D007660
-      target: UniProt:P25024
-    - key: positively regulates
-      source: UniProt:P25024
-      target: GO:0030593
-    - key: positively regulates
-      source: UniProt:P25024
-      target: GO:0002407
-    - key: positively correlated with
-      source: GO:0030593
-      target: HP:0005059
-    - key: positively correlated with
-      source: GO:0030593
-      target: HP:0001386
-    - key: positively correlated with
-      source: GO:0002407
-      target: GO:0006954
-    - key: positively correlated with
-      source: GO:0006954
-      target: MESH:D001172
-    - key: positively correlated with
-      source: HP:0005059
-      target: MESH:D001172
-    - key: positively correlated with
-      source: HP:0001386
-      target: MESH:D001172
-  multigraph: true
-  nodes:
-    - id: MESH:D007660
-      label: Drug
-      name: ketoprofen
-    - id: UniProt:P25024
-      label: Protein
-      name: C-X-C chemokine receptor type 1
-    - id: GO:0030593
-      label: BiologicalProcess
-      name: neutrophil chemotaxis
-    - id: GO:0002407
-      label: BiologicalProcess
-      name: dendritic cell chemotaxis
-    - id: HP:0005059
-      label: PhenotypicFeature
-      name: Arthralgia/arthritis
-    - id: HP:0001386
-      label: PhenotypicFeature
-      name: Joint swelling
-    - id: GO:0006954
-      label: BiologicalProcess
-      name: inflammatory response
-    - id: MESH:D001172
-      label: Disease
-      name: Rheumatoid arthritis
-  reference:
-    - https://go.drugbank.com/drugs/DB01009#BE0003552
-    - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943798/
-- directed: true
-  graph:
-    _id: DB01009_MESH_D004412_1
-    disease: Dysmenorrhea
-    disease_mesh: MESH:D004412
-    drug: ketoprofen
-    drug_mesh: MESH:D007660
-    drugbank: DB:DB01009
-  links:
-    - key: negatively regulates
-      source: MESH:D007660
-      target: UniProt:P23219
-    - key: negatively regulates
-      source: MESH:D007660
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively regulates
-      source: MESH:D011453
-      target: GO:0070471
-    - key: positively correlated with
-      source: GO:0070471
-      target: MESH:D004412
-  multigraph: true
-  nodes:
-    - id: MESH:D007660
-      label: Drug
-      name: ketoprofen
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: GO:0070471
-      label: BiologicalProcess
-      name: uterine smooth muscle contraction
-    - id: MESH:D004412
-      label: Disease
-      name: Dysmenorrhea
-  reference:
-    - https://go.drugbank.com/drugs/DB01009
-    - https://www.aafp.org/afp/1999/0801/p489.html
-- directed: true
-  graph:
-    _id: DB01009_MESH_D010003_1
-    disease: Osteoarthritis
-    disease_mesh: MESH:D010003
-    drug: ketoprofen
-    drug_mesh: MESH:D007660
-    drugbank: DB:DB01009
-  links:
-    - key: negatively regulates
-      source: MESH:D007660
-      target: UniProt:P23219
-    - key: negatively regulates
-      source: MESH:D007660
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0002829
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0001386
-    - key: positively correlated with
-      source: HP:0001386
-      target: MESH:D010003
-    - key: positively correlated with
-      source: HP:0002829
-      target: MESH:D010003
-  multigraph: true
-  nodes:
-    - id: MESH:D007660
-      label: Drug
-      name: ketoprofen
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: HP:0002829
-      label: PhenotypicFeature
-      name: Arthralgia
-    - id: HP:0001386
-      label: PhenotypicFeature
-      name: Joint swelling
-    - id: MESH:D010003
-      label: Disease
-      name: Osteoarthritis
-  reference: https://go.drugbank.com/drugs/DB01009
-  comment: In contrast to rheumatoid arthritis, in osteoarthritis the joints do not become hot or red.  (https://en.wikipedia.org/wiki/Osteoarthritis#cite_note-NIH2015-1)
-- directed: true
-  graph:
-    _id: DB00461_MESH_D010003_1
-    disease: Osteoarthritis
-    disease_mesh: MESH:D010003
-    drug: Nabumetone
-    drug_mesh: MESH:D007660
-    drugbank: DB:DB00461
-  links:
-    - key: produces
-      source: MESH:D007660
-      target: CHEBI:35628
-    - key: decreases activity of
-      source: CHEBI:35628
-      target: UniProt:P23219
-    - key: decreases activity of
-      source: CHEBI:35628
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0002829
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0001386
-    - key: positively correlated with
-      source: HP:0001386
-      target: MESH:D010003
-    - key: positively correlated with
-      source: HP:0002829
-      target: MESH:D010003
-  multigraph: true
-  nodes:
-    - id: MESH:D007660
-      label: Drug
-      name: Nabumetone
-    - id: CHEBI:35628
-      label: Drug
-      name: (6-methoxy-2-naphthyl)acetic acid
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: HP:0002829
-      label: PhenotypicFeature
-      name: Arthralgia
-    - id: HP:0001386
-      label: PhenotypicFeature
-      name: Joint swelling
-    - id: MESH:D010003
-      label: Disease
-      name: Osteoarthritis
-  reference:
-    - https://go.drugbank.com/drugs/DB00461#mechanism-of-action
-    - https://en.wikipedia.org/wiki/Nabumetone
-  comment: Nabumetone is a prodrug, which is metabolised into the pharmacologically active drug (CHEBI:35628, 6-methoxy-2-naphthyl acetic acid). Note that the drug preferentially blocks COX-2 activity.
-- directed: true
-  graph:
-    _id: DB00461_MESH_D001172_1
-    disease: Rheumatoid arthritis
-    disease_mesh: MESH:D001172
-    drug: Nabumetone
-    drug_mesh: MESH:D007660
-    drugbank: DB:DB00461
-  links:
-    - key: produces
-      source: MESH:D007660
-      target: CHEBI:35628
-    - key: decreases activity of
-      source: CHEBI:35628
-      target: UniProt:P23219
-    - key: decreases activity of
-      source: CHEBI:35628
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0002829
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0001386
-    - key: positively correlated with
-      source: HP:0001386
-      target: MESH:D001172
-    - key: positively correlated with
-      source: HP:0002829
-      target: MESH:D001172
-  multigraph: true
-  nodes:
-    - id: MESH:D007660
-      label: Drug
-      name: Nabumetone
-    - id: CHEBI:35628
-      label: Drug
-      name: (6-methoxy-2-naphthyl)acetic acid
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: HP:0002829
-      label: PhenotypicFeature
-      name: Arthralgia
-    - id: HP:0001386
-      label: PhenotypicFeature
-      name: Joint swelling
-    - id: MESH:D001172
-      label: Disease
-      name: Rheumatoid arthritis
-  reference:
-    - https://go.drugbank.com/drugs/DB00461#mechanism-of-action
-    - https://en.wikipedia.org/wiki/Nabumetone
-  comment: Nabumetone is a prodrug, which is metabolised into the pharmacologically active drug (CHEBI:35628, 6-methoxy-2-naphthyl acetic acid). Note that the drug preferentially blocks COX-2 activity.
-- directed: true
-  graph:
-    _id: DB09213_MESH_D001172_1
-    disease: Rheumatoid arthritis
-    disease_mesh: MESH:D001172
-    drug: dexibuprofen
-    drug_mesh: MESH:C539402
-    drugbank: DB:DB09213
-  links:
-    - key: decreases activity of
-      source: MESH:C539402
-      target: UniProt:P23219
-    - key: decreases activity of
-      source: MESH:C539402
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0002829
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0001386
-    - key: positively correlated with
-      source: HP:0001386
-      target: MESH:D001172
-    - key: positively correlated with
-      source: HP:0002829
-      target: MESH:D001172
-  multigraph: true
-  nodes:
-    - id: MESH:C539402
-      label: Drug
-      name: dexibuprofen
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: HP:0002829
-      label: PhenotypicFeature
-      name: Arthralgia
-    - id: HP:0001386
-      label: PhenotypicFeature
-      name: Joint swelling
-    - id: MESH:D001172
-      label: Disease
-      name: Rheumatoid arthritis
-  reference:
-    - https://go.drugbank.com/drugs/DB09213#BE0000262
-    - https://go.drugbank.com/drugs/DB09213#BE0000017
-    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL175/
-    - https://en.wikipedia.org/wiki/Ibuprofen#Pharmacology
-  comment: Dexibuprofen is an active enantiomer of ibuprofen.
-- directed: true
-  graph:
-    _id: DB09213_MESH_D001171_1
-    disease: Arthritis, Juvenile
-    disease_mesh: MESH:D001171
-    drug: dexibuprofen
-    drug_mesh: MESH:C539402
-    drugbank: DB:DB09213
-  links:
-    - key: decreases activity of
-      source: MESH:C539402
-      target: UniProt:P23219
-    - key: decreases activity of
-      source: MESH:C539402
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0002829
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0001386
-    - key: positively correlated with
-      source: HP:0001386
-      target: MESH:D001171
-    - key: positively correlated with
-      source: HP:0002829
-      target: MESH:D001171
-  multigraph: true
-  nodes:
-    - id: MESH:C539402
-      label: Drug
-      name: dexibuprofen
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: HP:0002829
-      label: PhenotypicFeature
-      name: Arthralgia
-    - id: HP:0001386
-      label: PhenotypicFeature
-      name: Joint swelling
-    - id: MESH:D001171
-      label: Disease
-      name: Arthritis, Juvenile
-  reference:
-    - https://go.drugbank.com/drugs/DB09213#BE0000262
-    - https://go.drugbank.com/drugs/DB09213#BE0000017
-    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL175/
-    - https://en.wikipedia.org/wiki/Ibuprofen#Pharmacology
-  comment: The disease is also known as Juvenile rheumatoid arthritis as per DrugCentral. Dexibuprofen is an active enantiomer of ibuprofen.
-- directed: true
-  graph:
-    _id: DB09213_MESH_D010003_1
-    disease: Osteoarthritis
-    disease_mesh: MESH:D010003
-    drug: dexibuprofen
-    drug_mesh: MESH:C539402
-    drugbank: DB:DB09213
-  links:
-    - key: decreases activity of
-      source: MESH:C539402
-      target: UniProt:P23219
-    - key: decreases activity of
-      source: MESH:C539402
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0002829
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0001386
-    - key: positively correlated with
-      source: HP:0001386
-      target: MESH:D010003
-    - key: positively correlated with
-      source: HP:0002829
-      target: MESH:D010003
-  multigraph: true
-  nodes:
-    - id: MESH:C539402
-      label: Drug
-      name: dexibuprofen
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: HP:0002829
-      label: PhenotypicFeature
-      name: Arthralgia
-    - id: HP:0001386
-      label: PhenotypicFeature
-      name: Joint swelling
-    - id: MESH:D010003
-      label: Disease
-      name: Osteoarthritis
-  reference:
-    - https://go.drugbank.com/drugs/DB09213#BE0000262
-    - https://go.drugbank.com/drugs/DB09213#BE0000017
-    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL175/
-    - https://en.wikipedia.org/wiki/Ibuprofen#Pharmacology
-  comment: Dexibuprofen is an active enantiomer of ibuprofen.
-- directed: true
-  graph:
-    _id: DB09213_MESH_D005334_1
-    disease: Fever
-    disease_mesh: MESH:D005334
-    drug: dexibuprofen
-    drug_mesh: MESH:C539402
-    drugbank: DB:DB09213
-  links:
-    - key: decreases activity of
-      source: MESH:C539402
-      target: UniProt:P23219
-    - key: decreases activity of
-      source: MESH:C539402
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: MESH:D005334
-  multigraph: true
-  nodes:
-    - id: MESH:C539402
-      label: Drug
-      name: dexibuprofen
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: MESH:D005334
-      label: Disease
-      name: Fever
-  reference:
-    - https://go.drugbank.com/drugs/DB09213#BE0000262
-    - https://go.drugbank.com/drugs/DB09213#BE0000017
-    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL175/
-    - https://en.wikipedia.org/wiki/Ibuprofen#Pharmacology
-    - https://en.wikipedia.org/wiki/Fever#PGE2_release
-  comment: Dexibuprofen is an active enantiomer of ibuprofen.
-- directed: true
-  graph:
-    _id: DB09213_MESH_D010146_1
-    disease: Pain
-    disease_mesh: MESH:D010146
-    drug: dexibuprofen
-    drug_mesh: MESH:C539402
-    drugbank: DB:DB09213
-  links:
-    - key: decreases activity of
-      source: MESH:C539402
-      target: UniProt:P23219
-    - key: decreases activity of
-      source: MESH:C539402
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: MESH:D010146
-  multigraph: true
-  nodes:
-    - id: MESH:C539402
-      label: Drug
-      name: dexibuprofen
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: MESH:D010146
-      label: Disease
-      name: Pain
-  reference:
-    - https://go.drugbank.com/drugs/DB09213#BE0000262
-    - https://go.drugbank.com/drugs/DB09213#BE0000017
-    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL175/
-    - https://en.wikipedia.org/wiki/Ibuprofen#Pharmacology
-    - https://en.wikipedia.org/wiki/Fever#PGE2_release
-  comment: Dexibuprofen is an active enantiomer of ibuprofen.
-- directed: true
-  graph:
-    _id: DB09213_MESH_D006261_1
-    disease: Headache Disorders
-    disease_mesh: MESH:D006261
-    drug: dexibuprofen
-    drug_mesh: MESH:C539402
-    drugbank: DB:DB09213
-  links:
-    - key: decreases activity of
-      source: MESH:C539402
-      target: UniProt:P23219
-    - key: decreases activity of
-      source: MESH:C539402
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0012531
-    - key: manifestation of
-      source: HP:0012531
-      target: MESH:D006261
-  multigraph: true
-  nodes:
-    - id: MESH:C539402
-      label: Drug
-      name: dexibuprofen
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: HP:0012531
-      label: PhenotypicFeature
-      name: Pain
-    - id: MESH:D006261
-      label: Disease
-      name: Headache Disorders
-  reference:
-    - https://go.drugbank.com/drugs/DB09213#BE0000262
-    - https://go.drugbank.com/drugs/DB09213#BE0000017
-    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL175/
-    - https://en.wikipedia.org/wiki/Ibuprofen#Pharmacology
-    - https://en.wikipedia.org/wiki/Fever#PGE2_release
-  comment: Dexibuprofen is an active enantiomer of ibuprofen.
-- directed: true
-  graph:
-    _id: DB09213_MESH_D004412_1
-    disease: Dysmenorrhea
-    disease_mesh: MESH:D004412
-    drug: dexibuprofen
-    drug_mesh: MESH:C539402
-    drugbank: DB:DB09213
-  links:
-    - key: decreases activity of
-      source: MESH:C539402
-      target: UniProt:P23219
-    - key: decreases activity of
-      source: MESH:C539402
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0012531
-    - key: manifestation of
-      source: HP:0012531
-      target: MESH:D004412
-  multigraph: true
-  nodes:
-    - id: MESH:C539402
-      label: Drug
-      name: dexibuprofen
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: HP:0012531
-      label: PhenotypicFeature
-      name: Pain
-    - id: MESH:D004412
-      label: Disease
-      name: Dysmenorrhea
-  reference:
-    - https://go.drugbank.com/drugs/DB09213#BE0000262
-    - https://go.drugbank.com/drugs/DB09213#BE0000017
-    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL175/
-    - https://en.wikipedia.org/wiki/Ibuprofen#Pharmacology
-    - https://en.wikipedia.org/wiki/Fever#PGE2_release
-  comment: Dexibuprofen is an active enantiomer of ibuprofen.
-- directed: true
-  graph:
-    _id: DB05016_MESH_D020388_1
-    disease: Muscular Dystrophy, Duchenne
-    disease_mesh: MESH:D020388
-    drug: ataluren
-    drug_mesh: MESH:C515878
-    drugbank: DB:DB05016
-  links:
-    - key: positively correlated with
-      source: MESH:C515878
-      target: UniProt:P11532
-    - key: disrupted by
-      source: UniProt:P11532
-      target: MESH:D018389
-    - key: predisposes
-      source: MESH:D018389
-      target: MESH:D059365
-    - key: positively correlated with
-      source: MESH:D059365
-      target: HP:0003323
-    - key: manifestation of
-      source: HP:0003323
-      target: MESH:D020388
-  multigraph: true
-  nodes:
-    - id: MESH:C515878
-      label: Drug
-      name: ataluren
-    - id: UniProt:P11532
-      label: Protein
-      name: Dystrophin
-    - id: MESH:D018389
-      label: ChemicalSubstance
-      name: Codon, Nonsense
-    - id: MESH:D059365
-      label: BiologicalProcess
-      name: Nonsense Mediated mRNA Decay
-    - id: HP:0003323
-      label: PhenotypicFeature
-      name: Progressive muscle weakness
-    - id: MESH:D020388
-      label: Disease
-      name: Muscular Dystrophy, Duchenne
-  reference:
-    - https://go.drugbank.com/drugs/DB05016#mechanism-of-action
-    - https://en.wikipedia.org/wiki/Ataluren#Pharmacology
-  comment: The drug enables ribosomes to bypass premature stop codons caused by nonsense mutations in the dystrophin gene. This restores the full-length and functional capability of dystrophin. Without the drug, the premature stop codon means that a truncated protein will be produced, which will be unabled to play its role in muscle strenght and proper function leading to the disease. The disease is denoted Duchenne muscular dystrophy in the original file as per DrugCentral.
-- directed: true
-  graph:
-    _id: DB01057_MESH_D004948_1
-    disease: Esotropia
-    disease_mesh: MESH:D004948
-    drug: Echothiophate Iodide
-    drug_mesh: MESH:D004456
-    drugbank: DB:DB01057
-  links:
-    - key: decreases activity of
-      source: MESH:D004456
-      target: UniProt:P22303
-    - key: decreases activity of
-      source: MESH:D004456
-      target: UniProt:P06276
-    - key: positively regulates
-      source: UniProt:P06276
-      target: GO:0003990
-    - key: decreases abundance of
-      source: GO:0003990
-      target: MESH:D000109
-    - key: positively regulates
-      source: UniProt:P22303
-      target: GO:0006581
-    - key: decreases abundance of
-      source: GO:0006581
-      target: MESH:D000109
-    - key: negatively correlated with
-      source: MESH:D000109
-      target: HP:0000549
-    - key: manifestation of
-      source: HP:0000549
-      target: MESH:D004948
-  multigraph: true
-  nodes:
-    - id: MESH:D004456
-      label: Drug
-      name: Echothiophate Iodide
-    - id: UniProt:P22303
-      label: Protein
-      name: Acetylcholinesterase
-    - id: UniProt:P06276
-      label: Protein
-      name: Cholinesterase
-    - id: GO:0003990
-      label: MolecularActivity
-      name: acetylcholinesterase activity
-    - id: GO:0006581
-      label: BiologicalProcess
-      name: acetylcholine catabolic process
-    - id: MESH:D000109
-      label: ChemicalSubstance
-      name: Acetylcholine
-    - id: HP:0000549
-      label: PhenotypicFeature
-      name: Abnormal conjugate eye movement
-    - id: MESH:D004948
-      label: Disease
-      name: Esotropia
-  reference:
-    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201341/
-    - https://go.drugbank.com/drugs/DB01057#BE0002180
-  comment: MESH:C061212 is not an alternative MESH ID for this drug (https://meshb.nlm.nih.gov/record/ui?ui=C061212).
-- directed: true
-  graph:
-    _id: DB01057_MESH_D005902_1
-    disease: Glaucoma, Open-Angle
-    disease_mesh: MESH:D005902
-    drug: Echothiophate Iodide
-    drug_mesh: MESH:D004456
-    drugbank: DB:DB01057
-  links:
-    - key: decreases activity of
-      source: MESH:D004456
-      target: UniProt:P22303
-    - key: decreases activity of
-      source: MESH:D004456
-      target: UniProt:P06276
-    - key: positively regulates
-      source: UniProt:P06276
-      target: GO:0003990
-    - key: decreases abundance of
-      source: GO:0003990
-      target: MESH:D000109
-    - key: positively regulates
-      source: UniProt:P22303
-      target: GO:0006581
-    - key: decreases abundance of
-      source: GO:0006581
-      target: MESH:D000109
-    - key: positively correlated with
-      source: MESH:D000109
-      target: HP:0000616
-    - key: negatively correlated with
-      source: HP:0000616
-      target: UBERON:0001796
-    - key: positively correlated with
-      source: UBERON:0001796
-      target: HP:0007906
-    - key: manifestation of
-      source: HP:0007906
-      target: MESH:D005902
-  multigraph: true
-  nodes:
-    - id: MESH:D004456
-      label: Drug
-      name: Echothiophate Iodide
-    - id: UniProt:P22303
-      label: Protein
-      name: Acetylcholinesterase
-    - id: UniProt:P06276
-      label: Protein
-      name: Cholinesterase
-    - id: GO:0003990
-      label: MolecularActivity
-      name: acetylcholinesterase activity
-    - id: GO:0006581
-      label: BiologicalProcess
-      name: acetylcholine catabolic process
-    - id: MESH:D000109
-      label: ChemicalSubstance
-      name: Acetylcholine
-    - id: HP:0000616
-      label: PhenotypicFeature
-      name: Miosis
-    - id: UBERON:0001796
-      label: GrossAnatomicalStructure
-      name: aqueous humor of eyeball
-    - id: HP:0007906
-      label: PhenotypicFeature
-      name: Ocular hypertension
-    - id: MESH:D005902
-      label: Disease
-      name: Glaucoma, Open-Angle
-  reference:
-    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201341/
-    - https://go.drugbank.com/drugs/DB01057#BE0002180
-  comment: The drug allows for the trabecular meshwork in the eye (UBERON:0005969) to open, increasing the outflow of the aqueous humor and having a positive impact on reducing intraocular pressure. Note that MESH:C061212 is not an alternative MESH ID for this drug (https://meshb.nlm.nih.gov/record/ui?ui=C061212). The disease is also known as Open-angle glaucoma as per in DrugCentral.
-- directed: true
-  graph:
-    _id: DB01057_MESH_D005901_1
-    disease: Glaucoma
-    disease_mesh: MESH:D005901
-    drug: Echothiophate Iodide
-    drug_mesh: MESH:D004456
-    drugbank: DB:DB01057
-  links:
-    - key: decreases activity of
-      source: MESH:D004456
-      target: UniProt:P22303
-    - key: decreases activity of
-      source: MESH:D004456
-      target: UniProt:P06276
-    - key: positively regulates
-      source: UniProt:P06276
-      target: GO:0003990
-    - key: decreases abundance of
-      source: GO:0003990
-      target: MESH:D000109
-    - key: positively regulates
-      source: UniProt:P22303
-      target: GO:0006581
-    - key: decreases abundance of
-      source: GO:0006581
-      target: MESH:D000109
-    - key: positively correlated with
-      source: MESH:D000109
-      target: HP:0000616
-    - key: negatively correlated with
-      source: HP:0000616
-      target: UBERON:0001796
-    - key: positively correlated with
-      source: UBERON:0001796
-      target: HP:0007906
-    - key: manifestation of
-      source: HP:0007906
-      target: MESH:D005901
-  multigraph: true
-  nodes:
-    - id: MESH:D004456
-      label: Drug
-      name: Echothiophate Iodide
-    - id: UniProt:P22303
-      label: Protein
-      name: Acetylcholinesterase
-    - id: UniProt:P06276
-      label: Protein
-      name: Cholinesterase
-    - id: GO:0003990
-      label: MolecularActivity
-      name: acetylcholinesterase activity
-    - id: GO:0006581
-      label: BiologicalProcess
-      name: acetylcholine catabolic process
-    - id: MESH:D000109
-      label: ChemicalSubstance
-      name: Acetylcholine
-    - id: HP:0000616
-      label: PhenotypicFeature
-      name: Miosis
-    - id: UBERON:0001796
-      label: GrossAnatomicalStructure
-      name: aqueous humor of eyeball
-    - id: HP:0007906
-      label: PhenotypicFeature
-      name: Ocular hypertension
-    - id: MESH:D005901
-      label: Disease
-      name: Glaucoma
-  reference:
-    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201341/
-    - https://go.drugbank.com/drugs/DB01057#BE0002180
-  comment: The drug allows for the trabecular meshwork in the eye (UBERON:0005969) to open, increasing the outflow of the aqueous humor and having a positive impact on reducing intraocular pressure. Note that MESH:C061212 is not an alternative MESH ID for this drug (https://meshb.nlm.nih.gov/record/ui?ui=C061212).
-- directed: true
-  graph:
-    _id: DB01057_MESH_D000080362_1
-    disease: Stargardt's disease
-    disease_mesh: MESH:D000080362
-    drug: Echothiophate Iodide
-    drug_mesh: MESH:D004456
-    drugbank: DB:DB01057
-  links:
-    - key: decreases activity of
-      source: MESH:D004456
-      target: UniProt:P22303
-    - key: decreases activity of
-      source: MESH:D004456
-      target: UniProt:P06276
-    - key: positively regulates
-      source: UniProt:P06276
-      target: GO:0003990
-    - key: decreases abundance of
-      source: GO:0003990
-      target: MESH:D000109
-    - key: positively regulates
-      source: UniProt:P22303
-      target: GO:0006581
-    - key: decreases abundance of
-      source: GO:0006581
-      target: MESH:D000109
-    - key: positively correlated with
-      source: MESH:D000109
-      target: HP:0000616
-    - key: negatively correlated with
-      source: HP:0000616
-      target: HP:0007663
-    - key: manifestation of
-      source: HP:0007663
-      target: MESH:D000080362
-  multigraph: true
-  nodes:
-    - id: MESH:D004456
-      label: Drug
-      name: Echothiophate Iodide
-    - id: UniProt:P22303
-      label: Protein
-      name: Acetylcholinesterase
-    - id: UniProt:P06276
-      label: Protein
-      name: Cholinesterase
-    - id: GO:0003990
-      label: MolecularActivity
-      name: acetylcholinesterase activity
-    - id: GO:0006581
-      label: BiologicalProcess
-      name: acetylcholine catabolic process
-    - id: MESH:D000109
-      label: ChemicalSubstance
-      name: Acetylcholine
-    - id: HP:0000616
-      label: PhenotypicFeature
-      name: Miosis
-    - id: HP:0007663
-      label: PhenotypicFeature
-      name: Reduced visual acuity
-    - id: MESH:D000080362
-      label: Disease
-      name: Stargardt's disease
-  reference:
-    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201341/
-    - https://go.drugbank.com/drugs/DB01057#BE0002180
-    - https://patents.google.com/patent/US7915312B2/en
-  comment: MESH:C061212 is not an alternative MESH ID for this drug (https://meshb.nlm.nih.gov/record/ui?ui=C061212).
-- directed: true
-  graph:
-    _id: DB11256_MESH_D000152_1
-    disease: Acne vulgaris
-    disease_mesh: MESH:D000152
-    drug: levomefolic acid
-    drug_mesh: MESH:C569381
-    drugbank: DB:DB11256
-  links:
-    - key: treats
-      source: MESH:C569381
-      target: MESH:D000152
-  multigraph: true
-  nodes:
-    - id: MESH:C569381
-      label: Drug
-      name: levomefolic acid
-    - id: MESH:D000152
-      label: Disease
-      name: Acne vulgaris
-  reference: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/022532Orig1s000CrossR.pdf
-  comment: Levomefolic acid can be found in contraceptive pills as a source of folic acid to help to prevent spinal cord birth defects in an unborn baby. There has not been any evidence to support that levomefolic acid on its own is an indication for acne vulgaris. When combined with hormones such as progestin and estrogen (birth pill) it can be used to treat moderate acne as well as premenstrual dysphoric disorder (https://www.webmd.com/drugs/2/drug-154717/beyaz-oral/details), but not on its own.
-- directed: true
-  graph:
-    _id: DB11256_MESH_D065446_1
-    disease: Premenstrual dysphoric disorder
-    disease_mesh: MESH:D065446
-    drug: levomefolic acid
-    drug_mesh: MESH:C569381
-    drugbank: DB:DB11256
-  links:
-    - key: treats
-      source: MESH:C569381
-      target: MESH:D065446
-  multigraph: true
-  nodes:
-    - id: MESH:C569381
-      label: Drug
-      name: levomefolic acid
-    - id: MESH:D065446
-      label: Disease
-      name: Premenstrual dysphoric disorder
-  reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=58cd12d3-39b1-4375-b7e0-09ba2378a52b
-  comment: Levomefolic acid can be found in contraceptive pills as a source of folic acid to help to prevent spinal cord birth defects in an unborn baby. There has not been any evidence to support that levomefolic acid on its own is an indication for acne vulgaris. When combined with hormones such as progestin and estrogen (birth pill) it can be used to treat moderate acne as well as premenstrual dysphoric disorder (https://www.webmd.com/drugs/2/drug-154717/beyaz-oral/details), but not on its own.
-- directed: true
-  graph:
-    _id: DB09221_MESH_D010437_1
-    disease: Peptic ulcer
-    disease_mesh: MESH:D010437
-    drug: polaprezinc
-    drug_mesh: MESH:C061957
-    drugbank: DB:DB09221
-  links:
-    - key: decreases abundance of
-      source: MESH:C061957
-      target: CHEBI:26523
-    - key: positively correlated with
-      source: MESH:C061957
-      target: GO:0070254
-    - key: negatively correlated with
-      source: MESH:C061957
-      target: GO:0006954
-    - key: positively correlated with
-      source: GO:0006954
-      target: MESH:D010437
-    - key: negatively correlated with
-      source: GO:0070254
-      target: MESH:D010437
-    - key: positively correlated with
-      source: MESH:C061957
-      target: GO:0042060
-    - key: negatively correlated with
-      source: MESH:C061957
-      target: NCBITaxon:210
-    - key: causes
-      source: NCBITaxon:210
-      target: MESH:D010437
-    - key: negatively correlated with
-      source: GO:0042060
-      target: MESH:D010437
-    - key: positively correlated with
-      source: CHEBI:26523
-      target: MESH:D010437
-  multigraph: true
-  nodes:
-    - id: MESH:C061957
-      label: Drug
-      name: polaprezinc
-    - id: CHEBI:26523
-      label: ChemicalSubstance
-      name: reactive oxygen species
-    - id: NCBITaxon:210
-      label: OrganismTaxon
-      name: Helicobacter pylori
-    - id: GO:0042060
-      label: BiologicalProcess
-      name: Wound Healing
-    - id: GO:0006954
-      label: BiologicalProcess
-      name: inflammatory response
-    - id: GO:0070254
-      label: BiologicalProcess
-      name: mucus secretion
-    - id: MESH:D010437
-      label: Disease
-      name: Peptic ulcer
-  reference: https://en.wikipedia.org/wiki/Zinc_L-carnosine#Mechanisms_of_action
-  comment: The drug stimulates the expression of several genes (e.g. HSP, SOD, etc) but it's not clear if the drug binds to these or other targets to modulate the known actions namely oxygen radical scavenging, anti-oxidation, anti-inflammation, and acceleration of gastrointestinal wound healing.
-- directed: true
-  graph:
-    _id: DB00482_MESH_D010003_1
-    disease: Osteoarthritis
-    disease_mesh: MESH:D010003
-    drug: celecoxib
-    drug_mesh: MESH:D000068579
-    drugbank: DB:DB00482
-  links:
-    - key: decreases activity of
-      source: MESH:D000068579
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0002829
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0001386
-    - key: manifestation of
-      source: HP:0001386
-      target: MESH:D010003
-    - key: manifestation of
-      source: HP:0002829
-      target: MESH:D010003
-  multigraph: true
-  nodes:
-    - id: MESH:D000068579
-      label: Drug
-      name: celecoxib
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: HP:0002829
-      label: PhenotypicFeature
-      name: Arthralgia
-    - id: HP:0001386
-      label: PhenotypicFeature
-      name: Joint swelling
-    - id: MESH:D010003
-      label: Disease
-      name: Osteoarthritis
-  reference:
-    - https://go.drugbank.com/drugs/DB00482
-    - https://en.wikipedia.org/wiki/Celecoxib#Anti-inflammatory
-- directed: true
-  graph:
-    _id: DB00482_MESH_D013167_1
-    disease: Ankylosing spondylitis
-    disease_mesh: MESH:D013167
-    drug: celecoxib
-    drug_mesh: MESH:D000068579
-    drugbank: DB:DB00482
-  links:
-    - key: decreases activity of
-      source: MESH:D000068579
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0002829
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0001386
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0001369
-    - key: manifestation of
-      source: HP:0001369
-      target: MESH:D013167
-    - key: manifestation of
-      source: HP:0001386
-      target: MESH:D013167
-    - key: manifestation of
-      source: HP:0002829
-      target: MESH:D013167
-  multigraph: true
-  nodes:
-    - id: MESH:D000068579
-      label: Drug
-      name: celecoxib
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: HP:0001369
-      label: PhenotypicFeature
-      name: Arthritis
-    - id: HP:0002829
-      label: PhenotypicFeature
-      name: Arthralgia
-    - id: HP:0001386
-      label: PhenotypicFeature
-      name: Joint swelling
-    - id: MESH:D013167
-      label: Disease
-      name: Ankylosing spondylitis
-  reference: https://go.drugbank.com/drugs/DB00482
-- directed: true
-  graph:
-    _id: DB00482_MESH_D001172_1
-    disease: Rheumatoid arthritis
-    disease_mesh: MESH:D001172
-    drug: celecoxib
-    drug_mesh: MESH:D000068579
-    drugbank: DB:DB00482
-  links:
-    - key: decreases activity of
-      source: MESH:D000068579
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0002829
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0001386
-    - key: manifestation of
-      source: HP:0001386
-      target: MESH:D001172
-    - key: manifestation of
-      source: HP:0002829
-      target: MESH:D001172
-  multigraph: true
-  nodes:
-    - id: MESH:D000068579
-      label: Drug
-      name: celecoxib
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: HP:0002829
-      label: PhenotypicFeature
-      name: Arthralgia
-    - id: HP:0001386
-      label: PhenotypicFeature
-      name: Joint swelling
-    - id: MESH:D001172
-      label: Disease
-      name: Rheumatoid arthritis
-  reference: https://go.drugbank.com/drugs/DB00482
-- directed: true
-  graph:
-    _id: DB00482_MESH_D001171_1
-    disease: Juvenile rheumatoid arthritis
-    disease_mesh: MESH:D001171
-    drug: celecoxib
-    drug_mesh: MESH:D000068579
-    drugbank: DB:DB00482
-  links:
-    - key: decreases activity of
-      source: MESH:D000068579
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0002829
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0001386
-    - key: manifestation of
-      source: HP:0001386
-      target: MESH:D001171
-    - key: manifestation of
-      source: HP:0002829
-      target: MESH:D001171
-  multigraph: true
-  nodes:
-    - id: MESH:D000068579
-      label: Drug
-      name: celecoxib
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: HP:0002829
-      label: PhenotypicFeature
-      name: Arthralgia
-    - id: HP:0001386
-      label: PhenotypicFeature
-      name: Joint swelling
-    - id: MESH:D001171
-      label: Disease
-      name: Juvenile rheumatoid arthritis
-  reference: https://go.drugbank.com/drugs/DB00482
-- directed: true
-  graph:
-    _id: DB06736_MESH_D001172_1
-    disease: Rheumatoid arthritis
-    disease_mesh: MESH:D001172
-    drug: aceclofenac
-    drug_mesh: MESH:C056498
-    drugbank: DB:DB06736
-  links:
-    - key: decreases activity of
-      source: MESH:C056498
-      target: UniProt:P23219
-    - key: decreases activity of
-      source: MESH:C056498
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0002829
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0001386
-    - key: manifestation of
-      source: HP:0001386
-      target: MESH:D001172
-    - key: manifestation of
-      source: HP:0002829
-      target: MESH:D001172
-  multigraph: true
-  nodes:
-    - id: MESH:C056498
-      label: Drug
-      name: aceclofenac
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: HP:0002829
-      label: PhenotypicFeature
-      name: Arthralgia
-    - id: HP:0001386
-      label: PhenotypicFeature
-      name: Joint swelling
-    - id: MESH:D001172
-      label: Disease
-      name: Rheumatoid arthritis
-  reference:
-    - https://go.drugbank.com/drugs/DB06736
-    - https://en.wikipedia.org/wiki/Aceclofenac#Chemistry
-- directed: true
-  graph:
-    _id: DB06736_MESH_D013167_1
-    disease: Ankylosing spondylitis
-    disease_mesh: MESH:D013167
-    drug: aceclofenac
-    drug_mesh: MESH:C056498
-    drugbank: DB:DB06736
-  links:
-    - key: decreases activity of
-      source: MESH:C056498
-      target: UniProt:P23219
-    - key: decreases activity of
-      source: MESH:C056498
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0002829
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0001386
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0001369
-    - key: manifestation of
-      source: HP:0001369
-      target: MESH:D013167
-    - key: manifestation of
-      source: HP:0001386
-      target: MESH:D013167
-    - key: manifestation of
-      source: HP:0002829
-      target: MESH:D013167
-  multigraph: true
-  nodes:
-    - id: MESH:C056498
-      label: Drug
-      name: aceclofenac
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: HP:0001369
-      label: PhenotypicFeature
-      name: Arthritis
-    - id: HP:0002829
-      label: PhenotypicFeature
-      name: Arthralgia
-    - id: HP:0001386
-      label: PhenotypicFeature
-      name: Joint swelling
-    - id: MESH:D013167
-      label: Disease
-      name: Ankylosing spondylitis
-  reference:
-    - https://go.drugbank.com/drugs/DB06736
-    - https://en.wikipedia.org/wiki/Aceclofenac#Chemistry
-    - https://en.wikipedia.org/wiki/Ankylosing_spondylitis#Medication
-- directed: true
-  graph:
-    _id: DB06736_MESH_D010003_1
-    disease: Osteoarthritis
-    disease_mesh: MESH:D010003
-    drug: aceclofenac
-    drug_mesh: MESH:C056498
-    drugbank: DB:DB06736
-  links:
-    - key: decreases activity of
-      source: MESH:C056498
-      target: UniProt:P23219
-    - key: decreases activity of
-      source: MESH:C056498
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0002829
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0001386
-    - key: manifestation of
-      source: HP:0001386
-      target: MESH:D010003
-    - key: manifestation of
-      source: HP:0002829
-      target: MESH:D010003
-  multigraph: true
-  nodes:
-    - id: MESH:C056498
-      label: Drug
-      name: aceclofenac
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: HP:0002829
-      label: PhenotypicFeature
-      name: Arthralgia
-    - id: HP:0001386
-      label: PhenotypicFeature
-      name: Joint swelling
-    - id: MESH:D010003
-      label: Disease
-      name: Osteoarthritis
-  reference:
-    - https://go.drugbank.com/drugs/DB06736
-    - https://en.wikipedia.org/wiki/Aceclofenac#Chemistry
-- directed: true
-  graph:
-    _id: DB06736_MESH_D001416_1
-    disease: Backache
-    disease_mesh: MESH:D001416
-    drug: aceclofenac
-    drug_mesh: MESH:C056498
-    drugbank: DB:DB06736
-  links:
-    - key: decreases activity of
-      source: MESH:C056498
-      target: UniProt:P23219
-    - key: decreases activity of
-      source: MESH:C056498
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0003326
-    - key: located in
-      source: HP:0003326
-      target: UBERON:0004479
-    - key: location of
-      source: UBERON:0004479
-      target: MESH:D001416
-  multigraph: true
-  nodes:
-    - id: MESH:C056498
-      label: Drug
-      name: aceclofenac
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: HP:0003326
-      label: PhenotypicFeature
-      name: Myalgia
-    - id: UBERON:0004479
-      label: GrossAnatomicalStructure
-      name: musculature of trunk
-    - id: MESH:D001416
-      label: Disease
-      name: Backache
-  reference:
-    - https://go.drugbank.com/drugs/DB06736
-    - https://en.wikipedia.org/wiki/Aceclofenac#Chemistry
-- directed: true
-  graph:
-    _id: DB01283_MESH_D010003_1
-    disease: Osteoarthritis
-    disease_mesh: MESH:D010003
-    drug: lumiracoxib
-    drug_mesh: MESH:C473384
-    drugbank: DB:DB01283
-  links:
-    - key: decreases activity of
-      source: MESH:C473384
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: MESH:D011453
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0002829
-    - key: positively correlated with
-      source: MESH:D011453
-      target: HP:0001386
-    - key: manifestation of
-      source: HP:0001386
-      target: MESH:D010003
-    - key: manifestation of
-      source: HP:0002829
-      target: MESH:D010003
-  multigraph: true
-  nodes:
-    - id: MESH:C473384
-      label: Drug
-      name: lumiracoxib
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: MESH:D011453
-      label: ChemicalSubstance
-      name: Prostaglandins
-    - id: HP:0002829
-      label: PhenotypicFeature
-      name: Arthralgia
-    - id: HP:0001386
-      label: PhenotypicFeature
-      name: Joint swelling
-    - id: MESH:D010003
-      label: Disease
-      name: Osteoarthritis
-  reference:
-    - https://go.drugbank.com/drugs/DB01283
-    - https://en.wikipedia.org/wiki/Lumiracoxib
-  comment: Withdrawn from the market in several countries. It has never been approved in the US.
-- directed: true
-  graph:
-    _id: DB00771_MESH_D004760_1
-    disease: Enterocolitis
-    disease_mesh: MESH:D004760
-    drug: clidinium
-    drug_mesh: MESH:C054940
-    drugbank: DB:DB00771
-  links:
-    - key: negatively regulates
-      source: MESH:C054940
-      target: UniProt:P11229
-    - key: positively regulates
-      source: UniProt:P11229
-      target: GO:0006939
-    - key: positively correlated with
-      source: GO:0006939
-      target: GO:0001696
-    - key: positively correlated with
-      source: GO:0006939
-      target: HP:0003394
-    - key: correlated with
-      source: GO:0001696
-      target: MESH:D004760
-    - key: correlated with
-      source: HP:0003394
-      target: MESH:D004760
-  multigraph: true
-  nodes:
-    - id: MESH:C054940
-      label: Drug
-      name: clidinium
-    - id: UniProt:P11229
-      label: Protein
-      name: Muscarinic acetylcholine receptor M1
-    - id: GO:0006939
-      label: BiologicalProcess
-      name: smooth muscle contraction
-    - id: GO:0001696
-      label: BiologicalProcess
-      name: Intestinal Secretions
-    - id: HP:0003394
-      label: PhenotypicFeature
-      name: Muscle spasm
-    - id: MESH:D004760
-      label: Disease
-      name: Enterocolitis
-  reference:
-    - https://go.drugbank.com/drugs/DB00771#mechanism-of-action
-    - https://en.wikipedia.org/wiki/Clidinium_bromide#Mechanism_of_action
-  comment: The disease, specially the acute form, is mainly caused by infection (https://en.wikipedia.org/wiki/Enterocolitis#Cause), leading to inflammation. So in addition to treating the symptoms (such as spams and GI secretions), antibiotics, anti-virals etc may be needed for treatment (https://en.wikipedia.org/wiki/Enterocolitis#Treatment).
-- directed: true
-  graph:
-    _id: DB00942_MESH_D010300_1
-    disease: Parkinson's disease
-    disease_mesh: MESH:D010300
-    drug: cycrimine
-    drug_mesh: MESH:C012262
-    drugbank: DB:DB00942
-  links:
-    - key: negatively regulates
-      source: MESH:C012262
-      target: UniProt:P11229
-    - key: positively regulates
-      source: UniProt:P11229
-      target: GO:0007271
-    - key: increases activity of
-      source: GO:0007271
-      target: GO:0014055
-    - key: positively correlated with
-      source: GO:0014055
-      target: MESH:D010300
-  multigraph: true
-  nodes:
-    - id: MESH:C012262
-      label: Drug
-      name: cycrimine
-    - id: UniProt:P11229
-      label: Protein
-      name: Muscarinic acetylcholine receptor M1
-    - id: GO:0007271
-      label: BiologicalProcess
-      name: synaptic transmission, cholinergic
-    - id: GO:0014055
-      label: BiologicalProcess
-      name: acetylcholine secretion, neurotransmission
-    - id: MESH:D010300
-      label: Disease
-      name: Parkinson's disease
-  reference: https://go.drugbank.com/drugs/DB00942#mechanism-of-action https://pubchem.ncbi.nlm.nih.gov/compound/2911#section=Pharmacology-and-Biochemistry
-  comment: In Parkinson's disease, there is imbalance between levels of acetylcholine and dopamine, where increased levels of acetylcholine and degeneration of dopaminergic pathways are observed. Therefore, muscarinic antagonists block central cholinergic activity and balance out neurotransmitters in the brain (https://en.wikipedia.org/wiki/Muscarinic_antagonist#Effects). Anticholinergic drugs may also be prescribed to improve bladder dysfunction (https://pubmed.ncbi.nlm.nih.gov/20370804/).
-- directed: true
-  graph:
-    _id: DB09119_MESH_D004828_1
-    disease: Epilepsies, Partial
-    disease_mesh: MESH:D004828
-    drug: eslicarbazepine acetate
-    drug_mesh: MESH:C416835
-    drugbank: DB:DB09119
-  links:
-    - key: has metabolite
-      source: MESH:C416835
-      target: MESH:C571001
-    - key: decreases activity of
-      source: MESH:C571001
-      target: InterPro:IPR001696
-    - key: positively regulates
-      source: InterPro:IPR001696
-      target: GO:0035725
-    - key: regulates
-      source: GO:0035725
-      target: GO:0019228
-    - key: contributes to
-      source: GO:0019228
-      target: HP:0011097
-    - key: positively correlated with
-      source: HP:0011097
-      target: MESH:D004828
-  multigraph: true
-  nodes:
-    - id: MESH:C416835
-      label: Drug
-      name: eslicarbazepine acetate
-    - id: MESH:C571001
-      label: Drug
-      name: eslicarbazepine
-    - id: InterPro:IPR001696
-      label: GeneFamily
-      name: Voltage gated sodium channel, alpha subunit
-    - id: GO:0035725
-      label: BiologicalProcess
-      name: sodium ion transmembrane transport
-    - id: GO:0019228
-      label: BiologicalProcess
-      name: neuronal action potential
-    - id: HP:0011097
-      label: PhenotypicFeature
-      name: Epileptic spasm
-    - id: MESH:D004828
-      label: Disease
-      name: Epilepsies, Partial
-  reference:
-    - https://pubchem.ncbi.nlm.nih.gov/compound/179344#section=Pharmacology-and-Biochemistry
-    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL87992/
-  comment: The antiseizure mechanism of action based on the voltage sodium channels is not a consensus (https://en.wikipedia.org/wiki/Eslicarbazepine_acetate#Mechanism_of_action). The drug could also bind to calcium channels (https://go.drugbank.com/drugs/DB09119#mechanism-of-action). Note that the protein target listed in DrugBank (https://go.drugbank.com/drugs/DB09119#BE0005793) does not seem to be involved in epilepsy, but rather in inflammation and pain.
-- directed: true
-  graph:
-    _id: DB00277_MESH_D008171_1
-    disease: Lung Diseases
-    disease_mesh: MESH:D008171
-    drug: theophylline
-    drug_mesh: MESH:D013806
-    drugbank: DB:DB00277
-  links:
-    - key: increases activity of
-      source: MESH:D013806
-      target: UniProt:Q92769
-    - key: positively regulates
-      source: UniProt:Q92769
-      target: GO:0016575
-    - key: negatively correlated with
-      source: GO:0016575
-      target: GO:0006954
-    - key: decreases activity of
-      source: MESH:D013806
-      target: InterPro:IPR023174
-    - key: decreases activity of
-      source: MESH:D013806
-      target: InterPro:IPR001634
-    - key: positively regulates
-      source: InterPro:IPR023174
-      target: GO:0006198
-    - key: negatively regulates
-      source: InterPro:IPR023174
-      target: GO:0019933
-    - key: positively regulates
-      source: InterPro:IPR001634
-      target: HP:4000007
-    - key: positively correlated with
-      source: HP:4000007
-      target: MESH:D008171
-    - key: positively regulates
-      source: InterPro:IPR001634
-      target: GO:0006954
-    - key: decreases abundance of
-      source: GO:0006198
-      target: CHEBI:17489
-    - key: increases abundance of
-      source: GO:0019933
-      target: CHEBI:17489
-    - key: positively correlated with
-      source: CHEBI:17489
-      target: GO:0044557
-    - key: negatively correlated with
-      source: CHEBI:17489
-      target: GO:0006954
-    - key: positively correlated with
-      source: GO:0006954
-      target: MESH:D008171
-    - key: negatively correlated with
-      source: GO:0044557
-      target: MESH:D008171
-  multigraph: true
-  nodes:
-    - id: MESH:D013806
-      label: Drug
-      name: theophylline
-      alt_ids:
-        - MESH:D000628
-        - MESH:D031210
-    - id: InterPro:IPR001634
-      label: GeneFamily
-      name: Adenosine receptor
-    - id: InterPro:IPR023174
-      label: GeneFamily
-      name: 3'5'-cyclic nucleotide phosphodiesterase, conserved site
-    - id: UniProt:Q92769
-      label: Protein
-      name: Histone deacetylase 2
-    - id: GO:0016575
-      label: BiologicalProcess
-      name: histone deacetylation
-    - id: GO:0006198
-      label: BiologicalProcess
-      name: cAMP catabolic process
-    - id: GO:0019933
-      label: BiologicalProcess
-      name: cAMP-mediated signaling
-    - id: GO:0006954
-      label: BiologicalProcess
-      name: inflammatory response
-    - id: GO:0044557
-      label: BiologicalProcess
-      name: relaxation of smooth muscle
-    - id: HP:4000007
-      label: PhenotypicFeature
-      name: Bronchoconstriction
-    - id: CHEBI:17489
-      label: ChemicalSubstance
-      name: 3',5'-cyclic AMP
-    - id: MESH:D008171
-      label: Disease
-      name: Lung Diseases
-  reference:
-    - https://go.drugbank.com/drugs/DB00277#mechanism-of-action
-    - https://en.wikipedia.org/wiki/Theophylline#Pharmacodynamics
-    - https://pubmed.ncbi.nlm.nih.gov/18660825/
-    - https://pubmed.ncbi.nlm.nih.gov/12212985/
-    - https://pubmed.ncbi.nlm.nih.gov/15980878/
-    - https://pubmed.ncbi.nlm.nih.gov/19762093/
-  comment: This disease is also known as Disorder of lung as per DrugCentral. Note this disease name is a very generic term, that could encompass any diseases of the lungs, including neoplasms, infectious diseases (e.g. tuberculosis) and rare diseases (e.g. cystic fibrosis) for which theophylline may not have any therapeutic benefit at all. Therefore, this annotation is done for all lung diseases that could be indications for this drug to encompass diseases that are similar to asthma, bronchitis, COPD and alike.
-- directed: true
-  graph:
-    _id: DB00445_MESH_D001943_1
-    disease: Breast Neoplasms
-    disease_mesh: MESH:D001943
-    drug: epirubicin
-    drug_mesh: MESH:D015251
-    drugbank: DB:DB00445
-  links:
-    - key: negatively regulates
-      source: MESH:D015251
-      target: GO:0140014
-    - key: positively correlated with
-      source: GO:0140014
-      target: HP:0031377
-    - key: positively correlated with
-      source: HP:0031377
-      target: MESH:D001943
-    - key: decreases abundance of
-      source: MESH:D015251
-      target: GO:0032993
-    - key: has participant
-      source: GO:0032993
-      target: UniProt:P11388
-    - key: positively correlated with
-      source: UniProt:P11388
-      target: GO:0006260
-    - key: increases abundance of
-      source: MESH:D015251
-      target: MESH:D005609
-    - key: positively correlated with
-      source: MESH:D005609
-      target: GO:0090734
-    - key: positively correlated with
-      source: GO:0090734
-      target: GO:0006915
-    - key: negatively correlated with
-      source: GO:0006915
-      target: MESH:D001943
-    - key: positively correlated with
-      source: GO:0006260
-      target: HP:0031377
-    - key: positively correlated with
-      source: GO:0006260
-      target: GO:0140014
-    - key: positively correlated with
-      source: GO:0140014
-      target: HP:0031377
-    - key: manifestation of
-      source: HP:0031377
-      target: MESH:D001943
-  multigraph: true
-  nodes:
-    - id: MESH:D015251
-      label: Drug
-      name: epirubicin
-    - id: UniProt:P11388
-      label: Protein
-      name: DNA topoisomerase 2-alpha
-    - id: GO:0032993
-      label: CellularComponent
-      name: protein-DNA complex
-    - id: MESH:D005609
-      label: ChemicalSubstance
-      name: Free Radicals
-    - id: GO:0090734
-      label: CellularComponent
-      name: site of DNA damage
-    - id: GO:0006260
-      label: BiologicalProcess
-      name: DNA replication
-    - id: HP:0031377
-      label: PhenotypicFeature
-      name: Abnormal cell proliferation
-    - id: GO:0006915
-      label: BiologicalProcess
-      name: apoptotic process
-    - id: GO:0140014
-      label: BiologicalProcess
-      name: mitotic nuclear division
-    - id: MESH:D001943
-      label: Disease
-      name: Breast Neoplasm
-  reference:
-    - https://go.drugbank.com/drugs/DB00445#mechanism-of-action
-    - https://en.wikipedia.org/wiki/Epirubicin
-  comment: The disease is denoted Carcinoma of breast in the original file as per DrugCentral. The drug intercaltes with DNA and prevents DNA replication and downstream processes, some of them involving UniProt:P11388, which leads to cell/tumour death.
-- directed: true
-  graph:
-    _id: DB00569_MESH_D020246_1
-    disease: Venous Thrombosis
-    disease_mesh: MESH:D020246
-    drug: fondaparinux
-    drug_mesh: MESH:D000077425
-    drugbank: DB:DB00569
-  links:
-    - key: positively regulates
-      source: MESH:D000077425
-      target: UniProt:P01008
-    - key: decreases activity of
-      source: UniProt:P01008
-      target: UniProt:P00742
-    - key: positively correlated with
-      source: UniProt:P00742
-      target: GO:0007596
-    - key: located in
-      source: GO:0007596
-      target: UBERON:0035552
-    - key: location of
-      source: UBERON:0035552
-      target: MESH:D020246
-  multigraph: true
-  nodes:
-    - id: MESH:D000077425
-      label: Drug
-      name: fondaparinux
-    - id: UniProt:P01008
-      label: Protein
-      name: Antithrombin-III
-    - id: UniProt:P00742
-      label: Protein
-      name: Coagulation factor X
-    - id: GO:0007596
-      label: BiologicalProcess
-      name: blood coagulation
-    - id: UBERON:0035552
-      label: GrossAnatomicalStructure
-      name: deep vein
-    - id: MESH:D020246
-      label: Disease
-      name: Venous Thrombosis
-  reference:
-    - https://go.drugbank.com/drugs/DB00569#BE0000280
-    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201202/
-    - https://en.wikipedia.org/wiki/Fondaparinux#Mechanism_of_action
-  comment: The disease is also known as Deep venous thrombosis as per DrugCentral. Note that among the original MESH IDs for this drug one of them seems to have been deprecated (MESH:C438268) whereas the other (MESH:C049714) is for a compound where no evidence has been found to be related to fondaparinux.
-- directed: true
-  graph:
-    _id: DB00569_MESH_D011655_1
-    disease: Pulmonary Embolism
-    disease_mesh: MESH:D011655
-    drug: fondaparinux
-    drug_mesh: MESH:D000077425
-    drugbank: DB:DB00569
-  links:
-    - key: positively regulates
-      source: MESH:D000077425
-      target: UniProt:P01008
-    - key: decreases activity of
-      source: UniProt:P01008
-      target: UniProt:P00742
-    - key: positively correlated with
-      source: UniProt:P00742
-      target: GO:0007596
-    - key: positively correlated with
-      source: GO:0007596
-      target: HP:0001907
-    - key: positively correlated with
-      source: HP:0001907
-      target: MESH:D011655
-  multigraph: true
-  nodes:
-    - id: MESH:D000077425
-      label: Drug
-      name: fondaparinux
-    - id: UniProt:P01008
-      label: Protein
-      name: Antithrombin-III
-    - id: UniProt:P00742
-      label: Protein
-      name: Coagulation factor X
-    - id: GO:0007596
-      label: BiologicalProcess
-      name: blood coagulation
-    - id: HP:0001907
-      label: PhenotypicFeature
-      name: Thromboembolism
-    - id: MESH:D011655
-      label: Disease
-      name: Pulmonary Embolism
-  reference:
-    - https://go.drugbank.com/drugs/DB00569#BE0000280
-    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201202/
-    - https://en.wikipedia.org/wiki/Fondaparinux#Mechanism_of_action
-  comment: The disease is also known as Pulmonary thromboembolism as per DrugCentral. Note that among the original MESH IDs for this drug one of them seems to have been deprecated (MESH:C438268) whereas the other (MESH:C049714) is for a compound where no evidence has been found to be related to fondaparinux.
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