diff --git a/submission.yaml b/submission.yaml
index af8ba45b2..8b1378917 100644
--- a/submission.yaml
+++ b/submission.yaml
@@ -1,1255 +1 @@
--   directed: true
-    graph:
-        drug: Tenofovir disoproxil
-        drugbank: DB:DB00300
-        drug_mesh: NULL
-        disease: Human immunodeficiency virus infection
-        disease_mesh: MESH:D015658
-    links:
-    -   key: increases abundance of
-        source: DB:DB00300
-        target: MESH:D000068698
-    -   key: has metabolite
-        source: MESH:D000068698
-        target: MESH:C583447
-    -   key: decreases activity of
-        source: MESH:C583447
-        target: UniProt:Q72547
-    -   key: negatively regulates
-        source: UniProt:Q72547
-        target: GO:0006351
-    -   key: in taxon
-        source: GO:0006351
-        target: NCBITaxon:12721
-    -   key: causes
-        source: NCBITaxon:12721
-        target: MESH:D015658
-    multigraph: true
-    nodes:
-    -   id: DB:DB00300
-        label: Drug
-        name: Tenofovir disoproxil
-    -   id: MESH:D000068698
-        label: Drug
-        name: tenofovir
-    -   id: MESH:C583447
-        label: ChemicalSubstance
-        name: tenofovir diphosphate
-    -   id: UniProt:Q72547
-        label: Protein
-        name: HIV-1 reverse transcriptase
-    -   id: GO:0006351
-        label: BiologicalProcess
-        name: DNA transcription
-    -   id: NCBITaxon:12721
-        label: OrganismTaxon
-        name: Human immunodeficiency virus
-    -   id: MESH:D015658
-        label: Disease
-        name: Human immunodeficiency virus infection
-    reference: https://go.drugbank.com/drugs/DB00300#mechanismofaction https://pubchem.ncbi.nlm.nih.gov/compound/Tenofovir-disoproxil#section=MeSH-Pharmacological-Classification https://en.wikipedia.org/wiki/Tenofovir_disoproxil
--   directed: true
-    graph:
-        drug: Tenofovir disoproxil
-        drugbank: DB:DB00300
-        drug_mesh: NULL
-        disease: Chronic type B viral hepatitis
-        disease_mesh: MESH:D019694
-    links:
-    -   key: increases abundance of
-        source: DB:DB00300
-        target: MESH:D000068698
-    -   key: has metabolite
-        source: MESH:D000068698
-        target: MESH:C583447
-    -   key: decreases activity of
-        source: MESH:C583447
-        target: UniProt:P24024
-    -   key: negatively regulates
-        source: UniProt:P24024
-        target: GO:0006260
-    -   key: in taxon
-        source: GO:0006260
-        target: NCBITaxon:10407
-    -   key: causes
-        source: NCBITaxon:10407
-        target: MESH:D019694
-    multigraph: true
-    nodes:
-    -   id: DB:DB00300
-        label: Drug
-        name: Tenofovir disoproxil
-    -   id: MESH:D000068698
-        label: Drug
-        name: tenofovir
-    -   id: MESH:C583447
-        label: ChemicalSubstance
-        name: tenofovir diphosphate
-    -   id: UniProt:P24024
-        label: Protein
-        name: Hepatitis B polymerase
-    -   id: GO:0006260
-        label: BiologicalProcess
-        name: DNA replication
-    -   id: NCBITaxon:10407
-        label: OrganismTaxon
-        name: Hepatitis B virus
-    -   id: MESH:D019694
-        label: Disease
-        name: Chronic type B viral hepatitis
-    reference: https://go.drugbank.com/drugs/DB00300#mechanismofaction https://pubchem.ncbi.nlm.nih.gov/compound/Tenofovir-disoproxil#section=MeSH-Pharmacological-Classification https://en.wikipedia.org/wiki/Tenofovir_disoproxil
--   directed: true
-    graph:
-        drug: Sinecatechins
-        drugbank: DB:DB01266
-        drug_mesh: NULL
-        disease: Condyloma acuminatum
-        disease_mesh: MESH:D003218
-    links:
-    -   key: decreases activity of
-        source: DB:DB01266
-        target: UniProt:P19838
-    -   key: positively regulates
-        source: UniProt:P19838
-        target: GO:1900119
-    -   key: decreases activity of
-        source: DB:DB01266
-        target: InterPro:IPR001245
-    -   key: positively regulates
-        source: InterPro:IPR001245
-        target: GO:1900119
-    -   key: increases activity of
-        source: DB:DB01266
-        target: UniProt:P04637   
-    -   key: positively regulates
-        source: UniProt:P04637
-        target: GO:1900119   
-    -   key: increases activity of
-        source: DB:DB01266
-        target: UniProt:P06400
-    -   key: positively regulates
-        source: UniProt:P06400
-        target: GO:1900119   
-    -   key: decreases activity of
-        source: DB:DB01266
-        target: InterPro:IPR000837
-    -   key: positively regulates
-        source: InterPro:IPR000837
-        target: GO:1900119   
-    -   key: decreases activity of
-        source: DB:DB01266
-        target: InterPro:IPR003545 
-    -   key: positively regulates
-        source: InterPro:IPR003545
-        target: GO:1900119           
-    -   key: decreases activity of
-        source: DB:DB01266
-        target: UniProt:P03129
-    -   key: positively regulates
-        source: UniProt:P03129
-        target: GO:1900119  
-    -   key: in taxon
-        source: GO:1900119 
-        target: NCBITaxon:10566
-    -   key: causes
-        source: NCBITaxon:10566
-        target: MESH:D003218
-    multigraph: true
-    nodes:
-    -   id: DB:DB01266
-        label: Drug
-        name: Sinecatechins
-    -   id: UniProt:P19838
-        label: Protein
-        name: Transcription factor NF-κB
-    -   id: InterPro:IPR001245
-        label: GeneFamily
-        name: receptor tyrosine kinase
-    -   id: UniProt:P04637
-        label: Protein
-        name: tumor suppressor gene p53
-    -   id: InterPro:IPR000837
-        label: GeneFamily
-        name: Transcription factor Activator protein-1
-    -   id: InterPro:IPR003545
-        label: GeneFamily
-        name: telomerase
-    -   id: UniProt:P06400
-        label: Protein
-        name: tumor suppressor gene pRb
-    -   id: GO:1900119
-        label: BiologicalProcess
-        name: apoptosis
-    -   id: UniProt:P03129
-        label: Protein
-        name: HPV-E7 gene expression
-    -   id: NCBITaxon:10566
-        label: OrganismTaxon
-        name: Human papillomavirus
-    -   id: MESH:D003218
-        label: Disease
-        name: Condyloma acuminatum
-    reference: https://go.drugbank.com/drugs/DB01266#mechanismofaction https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066610/ doi:10.4103/2589-0557.132415
--   directed: true
-    graph:
-        drug: Baricitinib
-        drugbank: DB:DB11817
-        drug_mesh: MESH:C000596027
-        disease: Rheumatoid arthritis
-        disease_mesh: MESH:D001172
-    links:
-    -   key: decreases activity of
-        source: MESH:C000596027
-        target: UniProt:P23458
-    -   key: decreases activity of
-        source: MESH:C000596027
-        target: UniProt:O60674
-    -   key: decreases activity of
-        source: MESH:C000596027
-        target: UniProt:P52333
-    -   key: decreases activity of
-        source: MESH:C000596027
-        target: UniProt:Q14289
-    -   key: positively regulates
-        source: UniProt:P23458
-        target: InterPro:IPR001217       
-    -   key: positively regulates
-        source: UniProt:O60674
-        target: InterPro:IPR001217   
-    -   key: positively regulates
-        source: UniProt:P52333
-        target: InterPro:IPR001217   
-    -   key: positively regulates
-        source: UniProt:Q14289
-        target: InterPro:IPR001217
-    -   key: decreases abundance of
-        source: InterPro:IPR001217
-        target: MESH:D016207
-    -   key: prevents
-        source: MESH:D016207
-        target: GO:0006954
-    -   key: contributes to
-        source: GO:0006954
-        target: MESH:D001172
-    multigraph: true
-    nodes:
-    -   id: MESH:C000596027
-        label: Drug
-        name: Baricitinib
-    -   id: UniProt:P23458
-        label: Protein
-        name: Janus kinase 1
-    -   id: UniProt:O60674
-        label: Protein
-        name: Janus kinase 2
-    -   id: UniProt:P52333
-        label: Protein
-        name: Janus kinase 3
-    -   id: UniProt:Q14289
-        label: Protein
-        name: Tyrosine Kinase 2
-    -   id: InterPro:IPR001217
-        label: GeneFamily
-        name: signal transducers and activators of transcription (STATs)
-    -   id: MESH:D016207
-        label: ChemicalSubstance
-        name: inflammatory cytokines
-    -   id: GO:0006954
-        label: BiologicalProcess
-        name: inflammatory response
-    -   id: MESH:D001172
-        label: Disease
-        name: Rheumatoid arthritis
-    reference: https://go.drugbank.com/drugs/DB11817#mechanismofaction
-
--   directed: true
-    graph:
-        drug: Fimasartan
-        drugbank: DB:DB09279
-        drug_mesh: MESH:C558933
-        disease: Hypertensive disorder
-        disease_mesh: MESH:D006973
-    links:
-    -   key: increases activity of
-        source: MESH:C558933
-        target: InterPro:IPR001004
-    -   key: positively regulates
-        source: InterPro:IPR001004
-        target: GO:0048243
-    -   key: decreases activity of
-        source: MESH:C558933
-        target: UniProt:P30556
-    -   key: positively regulates
-        source: UniProt:P30556
-        target: GO:0048243
-    -   key: decreases activity of
-        source: GO:0048243
-        target: GO:0042310
-    -   key: decreases secretion of
-        source: MESH:C558933
-        target: MESH:D000450
-    -   key: increases response to
-        source: MESH:D000450
-        target: GO:0035819
-    -   key: decreases activity of
-        source: GO:0035819
-        target: HP:0011104
-    -   key: negatively regulates
-        source: GO:0042310
-        target: HP:0011104
-    -   key: negatively regulates
-        source: HP:0011104
-        target: GO:0045776
-    -   key: correlated with
-        source: GO:0045776
-        target: MESH:D006973
-    multigraph: true
-    nodes:
-    -   id: MESH:C558933
-        label: Drug
-        name: Fimasartan
-    -   id: InterPro:IPR001004
-        label: GeneFamily
-        name: α1-adrenergic receptors
-    -   id: UniProt:P30556
-        label: Protein
-        name: Angiotensin II receptor type 1
-    -   id: GO:0048243
-        label: BiologicalProcess
-        name: noradrenaline release
-    -   id: GO:0042310
-        label: BiologicalProcess
-        name: vasoconstriction
-    -   id: MESH:D000450
-        label: ChemicalSubstance
-        name: aldosterone
-    -   id: GO:0035819
-        label: BiologicalProcess
-        name: natriuresis
-    -   id: HP:0011104
-        label: PhenotypicFeature
-        name: blood volume
-    -   id: GO:0045776
-        label: BiologicalProcess
-        name: blood pressure
-    -   id: MESH:D006973
-        label: Disease
-        name: Hypertensive disorder
-    reference: https://go.drugbank.com/drugs/DB09279#mechanismofaction https://en.wikipedia.org/wiki/Fimasartan#:~:text=Fimasartan%20is%20a%20non%2Dpeptide,of%20hypertension%20and%20heart%20failure.
--   directed: true
-    graph:
-        drug: Budesonide
-        drugbank: DB:DB01222
-        drug_mesh: MESH:D019819
-        disease: Crohn's disease
-        disease_mesh: MESH:D003424
-    links:
-    -   key: molecularly interacts with
-        source: MESH:D019819
-        target: UniProt:P04150
-    -   key: negatively regulates
-        source: UniProt:P04150
-        target: REACT:R-HSA-177662
-    -   key: prevents
-        source: REACT:R-HSA-177662
-        target: GO:0006954
-    -   key: correlated with
-        source: GO:0006954
-        target: MESH:D003424
-    multigraph: true
-    nodes:
-    -   id: MESH:D019819
-        label: Drug
-        name: Budesonide
-    -   id: UniProt:P04150
-        label: Protein
-        name: glucocorticoid receptor
-    -   id: REACT:R-HSA-177662
-        label: Pathway
-        name: NF-Kappa B pathway
-    -   id: GO:0006954
-        label: BiologicalProcess
-        name: inflammation
-    -   id: MESH:D003424
-        label: Disease
-        name: Crohn's disease
-    reference: https://go.drugbank.com/drugs/DB01222#mechanismofaction https://pubchem.ncbi.nlm.nih.gov/compound/Budesonide#section=Pharmacology doi:10.1165/rcmb.2016-0068OC
--   directed: true
-    graph:
-        drug: Budesonide
-        drugbank: DB:DB01222
-        drug_mesh: MESH:D019819
-        disease: Asthma
-        disease_mesh: MESH:D001249
-    links:
-    -   key: molecularly interacts with
-        source: MESH:D019819
-        target: UniProt:P04150
-    -   key: negatively regulates
-        source: UniProt:P04150
-        target: REACT:R-HSA-177662
-    -   key: prevents
-        source: REACT:R-HSA-177662
-        target: GO:0006954
-    -   key: correlated with
-        source: GO:0006954
-        target: MESH:D001249
-    multigraph: true
-    nodes:
-    -   id: MESH:D019819
-        label: Drug
-        name: Budesonide
-    -   id: UniProt:P04150
-        label: Protein
-        name: glucocorticoid receptor
-    -   id: REACT:R-HSA-177662
-        label: Pathway
-        name: NF-Kappa B pathway
-    -   id: GO:0006954
-        label: BiologicalProcess
-        name: inflammation
-    -   id: MESH:D001249
-        label: Disease
-        name: Asthma
-    reference: https://go.drugbank.com/drugs/DB01222#mechanismofaction https://pubchem.ncbi.nlm.nih.gov/compound/Budesonide#section=Pharmacology doi:10.1165/rcmb.2016-0068OC
--   directed: true
-    graph:
-        drug: Budesonide
-        drugbank: DB:DB01222
-        drug_mesh: MESH:D019819
-        disease: Allergic rhinitis
-        disease_mesh: MESH:D065631
-    links:
-    -   key: molecularly interacts with
-        source: MESH:D019819
-        target: UniProt:P04150
-    -   key: negatively regulates
-        source: UniProt:P04150
-        target: REACT:R-HSA-177662
-    -   key: prevents
-        source: REACT:R-HSA-177662
-        target: GO:0006954
-    -   key: correlated with
-        source: GO:0006954
-        target: MESH:D065631
-    multigraph: true
-    nodes:
-    -   id: MESH:D019819
-        label: Drug
-        name: Budesonide
-    -   id: UniProt:P04150
-        label: Protein
-        name: glucocorticoid receptor
-    -   id: REACT:R-HSA-177662
-        label: Pathway
-        name: NF-Kappa B pathway
-    -   id: GO:0006954
-        label: BiologicalProcess
-        name: inflammation
-    -   id: MESH:D065631
-        label: Disease
-        name: Allergic rhinitis
-    reference: https://go.drugbank.com/drugs/DB01222#mechanismofaction https://pubchem.ncbi.nlm.nih.gov/compound/Budesonide#section=Pharmacology doi:10.1165/rcmb.2016-0068OC
--   directed: true
-    graph:
-        drug: Budesonide
-        drugbank: DB:DB01222
-        drug_mesh: MESH:D019819
-        disease: Crohn's disease
-        disease_mesh: MESH:D003424
-    links:
-    -   key: molecularly interacts with
-        source: MESH:D019819
-        target: UniProt:P04150
-    -   key: increases abundance of
-        source: UniProt:P04150
-        target: UniProt:P04083
-    -   key: decreases activity of
-        source: UniProt:P04083
-        target: InterPro:IPR001211
-    -   key: increases abundance of
-        source: UniProt:P04150
-        target: UniProt:P22301
-    -   key: decreases activity of
-        source: UniProt:P22301
-        target: InterPro:IPR001211
-    -   key: prevents
-        source: InterPro:IPR001211
-        target: GO:0050482
-    -   key: negatively regulates
-        source: GO:0050482
-        target: GO:0019370
-    -   key: prevents
-        source: GO:0019370
-        target: GO:0006954
-    -   key: negatively regulates
-        source: GO:0050482
-        target: GO:0001516
-    -   key: prevents
-        source: GO:0001516
-        target: GO:0006954
-    -   key: correlated with
-        source: GO:0006954
-        target: MESH:D003424
-    multigraph: true
-    nodes:
-    -   id: MESH:D019819
-        label: Drug
-        name: Budesonide
-    -   id: UniProt:P04150
-        label: Protein
-        name: glucocorticoid receptor
-    -   id: UniProt:P04083
-        label: Protein
-        name: Annexin A1
-    -   id: UniProt:P22301
-        label: Protein
-        name: Interleukin 10
-    -   id: GO:0019370
-        label: Protein
-        name: leukotriene synthesis
-    -   id: InterPro:IPR001211
-        label: GeneFamily
-        name: phospholipase A2
-    -   id: GO:0050482
-        label: BiologicalProcess
-        name: arachidonic acid release
-    -   id: GO:0001516
-        label: BiologicalProcess
-        name: prostaglandin synthesis
-    -   id: GO:0006954
-        label: BiologicalProcess
-        name: inflammation
-    -   id: MESH:D003424
-        label: Disease
-        name: Crohn's disease
-    reference: https://go.drugbank.com/drugs/DB01222#mechanismofaction https://pubchem.ncbi.nlm.nih.gov/compound/Budesonide#section=Pharmacology doi:10.1165/rcmb.2016-0068OC
--   directed: true
-    graph:
-        drug: Budesonide
-        drugbank: DB:DB01222
-        drug_mesh: MESH:D019819
-        disease: Asthma
-        disease_mesh: MESH:D001249
-    links:
-    -   key: molecularly interacts with
-        source: MESH:D019819
-        target: UniProt:P04150
-    -   key: increases abundance of
-        source: UniProt:P04150
-        target: UniProt:P04083
-    -   key: decreases activity of
-        source: UniProt:P04083
-        target: InterPro:IPR001211
-    -   key: increases abundance of
-        source: UniProt:P04150
-        target: UniProt:P22301
-    -   key: decreases activity of
-        source: UniProt:P22301
-        target: InterPro:IPR001211
-    -   key: prevents
-        source: InterPro:IPR001211
-        target: GO:0050482
-    -   key: negatively regulates
-        source: GO:0050482
-        target: GO:0019370
-    -   key: prevents
-        source: GO:0019370
-        target: GO:0006954
-    -   key: negatively regulates
-        source: GO:0050482
-        target: GO:0001516
-    -   key: prevents
-        source: GO:0001516
-        target: GO:0006954
-    -   key: correlated with
-        source: GO:0006954
-        target: MESH:D001249
-    multigraph: true
-    nodes:
-    -   id: MESH:D019819
-        label: Drug
-        name: Budesonide
-    -   id: UniProt:P04150
-        label: Protein
-        name: glucocorticoid receptor
-    -   id: UniProt:P04083
-        label: Protein
-        name: Annexin A1
-    -   id: UniProt:P22301
-        label: Protein
-        name: Interleukin 10
-    -   id: GO:0019370
-        label: Protein
-        name: leukotriene synthesis
-    -   id: InterPro:IPR001211
-        label: GeneFamily
-        name: phospholipase A2
-    -   id: GO:0050482
-        label: BiologicalProcess
-        name: arachidonic acid release
-    -   id: GO:0001516
-        label: BiologicalProcess
-        name: prostaglandin synthesis
-    -   id: GO:0006954
-        label: BiologicalProcess
-        name: inflammation
-    -   id: MESH:D001249
-        label: Disease
-        name: Asthma
-    reference: https://go.drugbank.com/drugs/DB01222#mechanismofaction https://pubchem.ncbi.nlm.nih.gov/compound/Budesonide#section=Pharmacology doi:10.1165/rcmb.2016-0068OC
--   directed: true
-    graph:
-        drug: Budesonide
-        drugbank: DB:DB01222
-        drug_mesh: MESH:D019819
-        disease: Allergic rhinitis
-        disease_mesh: MESH:D065631
-    links:
-    -   key: molecularly interacts with
-        source: MESH:D019819
-        target: UniProt:P04150
-    -   key: increases abundance of
-        source: UniProt:P04150
-        target: UniProt:P04083
-    -   key: decreases activity of
-        source: UniProt:P04083
-        target: InterPro:IPR001211
-    -   key: increases abundance of
-        source: UniProt:P04150
-        target: UniProt:P22301
-    -   key: decreases activity of
-        source: UniProt:P22301
-        target: InterPro:IPR001211
-    -   key: prevents
-        source: InterPro:IPR001211
-        target: GO:0050482
-    -   key: negatively regulates
-        source: GO:0050482
-        target: GO:0019370
-    -   key: prevents
-        source: GO:0019370
-        target: GO:0006954
-    -   key: negatively regulates
-        source: GO:0050482
-        target: GO:0001516
-    -   key: prevents
-        source: GO:0001516
-        target: GO:0006954
-    -   key: correlated with
-        source: GO:0006954
-        target: MESH:D065631
-    multigraph: true
-    nodes:
-    -   id: MESH:D019819
-        label: Drug
-        name: Budesonide
-    -   id: UniProt:P04150
-        label: Protein
-        name: glucocorticoid receptor
-    -   id: UniProt:P04083
-        label: Protein
-        name: Annexin A1
-    -   id: UniProt:P22301
-        label: Protein
-        name: Interleukin 10
-    -   id: GO:0019370
-        label: Protein
-        name: leukotriene synthesis
-    -   id: InterPro:IPR001211
-        label: GeneFamily
-        name: phospholipase A2
-    -   id: GO:0050482
-        label: BiologicalProcess
-        name: arachidonic acid release
-    -   id: GO:0001516
-        label: BiologicalProcess
-        name: prostaglandin synthesis
-    -   id: GO:0006954
-        label: BiologicalProcess
-        name: inflammation
-    -   id: MESH:D065631
-        label: Disease
-        name: Allergic rhinitis
-    reference: https://go.drugbank.com/drugs/DB01222#mechanismofaction https://pubchem.ncbi.nlm.nih.gov/compound/Budesonide#section=Pharmacology doi:10.1165/rcmb.2016-0068OC
--   directed: true
-    graph:
-        drug: Calcium carbonate
-        drugbank: DB:DB06724
-        drug_mesh: MESH:D002119
-        disease: Hypocalcemia
-        disease_mesh: MESH:D006996
-    links:
-    -   key: increases abundance of
-        source: MESH:D002119
-        target: MESH:D002118
-    -   key: contributes to
-        source: MESH:D002118
-        target: MESH:D006996
-    multigraph: true
-    nodes:
-    -   id: MESH:D002119
-        label: Drug
-        name: Calcium carbonate
-    -   id: MESH:D002118
-        label: ChemicalSubstance
-        name: Calcium
-    -   id: MESH:D006996
-        label: Disease
-        name: Hypocalcemia
-    reference: https://go.drugbank.com/drugs/DB06724#mechanismofaction
--   directed: true
-    graph:
-        drug: Calcium carbonate
-        drugbank: DB:DB06724
-        drug_mesh: MESH:D002119
-        disease: Indigestion
-        disease_mesh: MESH:D004415
-    links:
-    -   key: decreases activity of
-        source: MESH:D002119
-        target: InterPro:IPR034162
-    -   key: prevents
-        source: InterPro:IPR034162
-        target: GO:0046717
-    -   key: decreases activity of
-        source: MESH:D002119
-        target: GO:0009268
-    -   key: prevents
-        source: GO:0009268
-        target: GO:0046717
-    -   key: decreases activity of
-        source: MESH:D002119
-        target: GO:0032310
-    -   key: prevents
-        source: GO:0032310
-        target: GO:0046717
-    -   key: decreases activity of
-        source: MESH:D002119
-        target: InterPro:IPR034162
-    -   key: prevents
-        source: InterPro:IPR034162
-        target: GO:0046717
-    -   key: causes
-        source: GO:0046717
-        target: MESH:D004415
-    multigraph: true
-    nodes:
-    -   id: MESH:D002119
-        label: Drug
-        name: Calcium carbonate
-    -   id: InterPro:IPR034162
-        label: GeneFamily
-        name: Pepsin
-    -   id: GO:0009268
-        label: BiologicalProcess
-        name: Response to pH
-    -   id: GO:0032310
-        label: BiologicalProcess
-        name: Prostaglandin secretion
-    -   id: GO:0046717
-        label: BiologicalProcess
-        name: Acid secretion
-    -   id: MESH:D004415
-        label: Disease
-        name: Indigestion
-    reference: https://go.drugbank.com/drugs/DB06724#mechanismofaction
--   directed: true
-    graph:
-        drug: Cefprozil
-        drugbank: DB:DB01150
-        drug_mesh: MESH:C052018
-        disease: Bronchitis
-        disease_mesh: MESH:D001991
-    links:
-    -   key: increases activity of
-        source: MESH:C052018
-        target: UniProt:Q04707
-    -   key: negatively regulates
-        source: UniProt:Q04707
-        target: GO:0042546
-    -   key: increases activity of
-        source: MESH:C052018
-        target: InterPro:IPR033907
-    -   key: contributes to
-        source: InterPro:IPR033907
-        target: GO:0008219
-    -   key: negatively regulates
-        source: MESH:C052018
-        target: GO:0018104
-    -   key: contributes to
-        source: GO:0018104
-        target: GO:0008219
-    -   key: in taxon
-        source: GO:0042546
-        target: NCBITaxon:1313
-    -   key: in taxon
-        source: GO:0008219
-        target: NCBITaxon:1313
-    -   key: causes
-        source: NCBITaxon:1313
-        target: MESH:D001991
-    multigraph: true
-    nodes:
-    -   id: MESH:C052018
-        label: Drug
-        name: Cefprozil
-    -   id: UniProt:Q04707
-        label: Protein
-        name: penicillin-binding proteins
-    -   id: InterPro:IPR033907
-        label: GeneFamily
-        name: Autolysins
-    -   id: GO:0018104
-        label: BiologicalProcess
-        name: Peptidoglycan-protein cross-linking
-    -   id: GO:0042546
-        label: BiologicalProcess
-        name: Cell wall biogenesis
-    -   id: GO:0008219
-        label: BiologicalProcess
-        name: Cell death
-    -   id: NCBITaxon:1313
-        label: OrganismTaxon
-        name: Streptococcus pneumoniae
-    -   id: MESH:D001991
-        label: Disease
-        name: Bronchitis
-    reference: https://go.drugbank.com/drugs/DB01150#mechanismofaction http://www.antimicrobe.org/drugpopup/Cefprozil.htm
--   directed: true
-    graph:
-        drug: Cefprozil
-        drugbank: DB:DB01150
-        drug_mesh: MESH:C052018
-        disease: Upper respiratory infection
-        disease_mesh: MESH:D012141
-    links:
-    -   key: increases activity of
-        source: MESH:C052018
-        target: UniProt:P45299
-    -   key: negatively regulates
-        source: UniProt:P45299
-        target: GO:0042546
-    -   key: increases activity of
-        source: MESH:C052018
-        target: InterPro:IPR033907
-    -   key: contributes to
-        source: InterPro:IPR033907
-        target: GO:0008219
-    -   key: negatively regulates
-        source: MESH:C052018
-        target: GO:0018104
-    -   key: contributes to
-        source: GO:0018104
-        target: GO:0008219
-    -   key: in taxon
-        source: GO:0042546
-        target: NCBITaxon:727
-    -   key: in taxon
-        source: GO:0008219
-        target: NCBITaxon:727
-    -   key: causes
-        source: NCBITaxon:727
-        target: MESH:D012141
-    multigraph: true
-    nodes:
-    -   id: MESH:C052018
-        label: Drug
-        name: Cefprozil
-    -   id: UniProt:P45299
-        label: Protein
-        name: penicillin-binding proteins
-    -   id: InterPro:IPR033907
-        label: GeneFamily
-        name: Autolysins
-    -   id: GO:0018104
-        label: BiologicalProcess
-        name: Peptidoglycan-protein cross-linking
-    -   id: GO:0042546
-        label: BiologicalProcess
-        name: Cell wall biogenesis
-    -   id: GO:0008219
-        label: BiologicalProcess
-        name: Cell death
-    -   id: NCBITaxon:727
-        label: OrganismTaxon
-        name: Haemophilus influenzae
-    -   id: MESH:D012141
-        label: Disease
-        name: Upper respiratory infection
-    reference: https://go.drugbank.com/drugs/DB01150#mechanismofaction http://www.antimicrobe.org/drugpopup/Cefprozil.htm
--   directed: true
-    graph:
-        drug: Cefprozil
-        drugbank: DB:DB01150
-        drug_mesh: MESH:C052018
-        disease: Streptococcus pyogenes infection
-        disease_mesh: MESH:D013290
-    links:
-    -   key: increases activity of
-        source: MESH:C052018
-        target: InterPro:IPR001460
-    -   key: negatively regulates
-        source: InterPro:IPR001460
-        target: GO:0042546
-    -   key: increases activity of
-        source: MESH:C052018
-        target: InterPro:IPR033907
-    -   key: contributes to
-        source: InterPro:IPR033907
-        target: GO:0008219
-    -   key: negatively regulates
-        source: MESH:C052018
-        target: GO:0018104
-    -   key: contributes to
-        source: GO:0018104
-        target: GO:0008219
-    -   key: in taxon
-        source: GO:0042546
-        target: NCBITaxon:1314
-    -   key: in taxon
-        source: GO:0008219
-        target: NCBITaxon:1314
-    -   key: causes
-        source: NCBITaxon:1314
-        target: MESH:D013290
-    multigraph: true
-    nodes:
-    -   id: MESH:C052018
-        label: Drug
-        name: Cefprozil
-    -   id: InterPro:IPR001460
-        label: GeneFamily
-        name: penicillin-binding proteins
-    -   id: InterPro:IPR033907
-        label: GeneFamily
-        name: Autolysins
-    -   id: GO:0018104
-        label: BiologicalProcess
-        name: Peptidoglycan-protein cross-linking
-    -   id: GO:0042546
-        label: BiologicalProcess
-        name: Cell wall biogenesis
-    -   id: GO:0008219
-        label: BiologicalProcess
-        name: Cell death
-    -   id: NCBITaxon:1314
-        label: OrganismTaxon
-        name: Streptococcus pyogenes
-    -   id: MESH:D013290
-        label: Disease
-        name: Streptococcus pyogenes infection
-    reference: https://go.drugbank.com/drugs/DB01150#mechanismofaction http://www.antimicrobe.org/drugpopup/Cefprozil.htm
--   directed: true
-    graph:
-        drug: Cefprozil
-        drugbank: DB:DB01150
-        drug_mesh: MESH:C052018
-        disease: Tonsillitis
-        disease_mesh: MESH:D014069
-    links:
-    -   key: increases activity of
-        source: MESH:C052018
-        target: InterPro:IPR001460
-    -   key: negatively regulates
-        source: InterPro:IPR001460
-        target: GO:0042546
-    -   key: increases activity of
-        source: MESH:C052018
-        target: InterPro:IPR033907
-    -   key: contributes to
-        source: InterPro:IPR033907
-        target: GO:0008219
-    -   key: negatively regulates
-        source: MESH:C052018
-        target: GO:0018104
-    -   key: contributes to
-        source: GO:0018104
-        target: GO:0008219
-    -   key: in taxon
-        source: GO:0042546
-        target: NCBITaxon:1314
-    -   key: in taxon
-        source: GO:0008219
-        target: NCBITaxon:1314
-    -   key: causes
-        source: NCBITaxon:1314
-        target: MESH:D014069
-    multigraph: true
-    nodes:
-    -   id: MESH:C052018
-        label: Drug
-        name: Cefprozil
-    -   id: InterPro:IPR001460
-        label: GeneFamily
-        name: penicillin-binding proteins
-    -   id: InterPro:IPR033907
-        label: GeneFamily
-        name: Autolysins
-    -   id: GO:0018104
-        label: BiologicalProcess
-        name: Peptidoglycan-protein cross-linking
-    -   id: GO:0042546
-        label: BiologicalProcess
-        name: Cell wall biogenesis
-    -   id: GO:0008219
-        label: BiologicalProcess
-        name: Cell death
-    -   id: NCBITaxon:1314
-        label: OrganismTaxon
-        name: Streptococcus pyogenes
-    -   id: MESH:D014069
-        label: Disease
-        name: Tonsillitis
-    reference: https://go.drugbank.com/drugs/DB01150#mechanismofaction http://www.antimicrobe.org/drugpopup/Cefprozil.htm
--   directed: true
-    graph:
-        drug: Cefprozil
-        drugbank: DB:DB01150
-        drug_mesh: MESH:C052018
-        disease: Infection due to Staphylococcus aureus
-        disease_mesh: MESH:D013203
-    links:
-    -   key: increases activity of
-        source: MESH:C052018
-        target: UniProt:Q53613
-    -   key: negatively regulates
-        source: UniProt:Q53613
-        target: GO:0042546
-    -   key: increases activity of
-        source: MESH:C052018
-        target: InterPro:IPR033907
-    -   key: contributes to
-        source: InterPro:IPR033907
-        target: GO:0008219
-    -   key: negatively regulates
-        source: MESH:C052018
-        target: GO:0018104
-    -   key: contributes to
-        source: GO:0018104
-        target: GO:0008219
-    -   key: in taxon
-        source: GO:0042546
-        target: NCBITaxon:1280
-    -   key: in taxon
-        source: GO:0008219
-        target: NCBITaxon:1280
-    -   key: causes
-        source: NCBITaxon:1280
-        target: MESH:D013203
-    multigraph: true
-    nodes:
-    -   id: MESH:C052018
-        label: Drug
-        name: Cefprozil
-    -   id: UniProt:Q53613
-        label: Protein
-        name: penicillin-binding proteins
-    -   id: InterPro:IPR033907
-        label: GeneFamily
-        name: Autolysins
-    -   id: GO:0018104
-        label: BiologicalProcess
-        name: Peptidoglycan-protein cross-linking
-    -   id: GO:0042546
-        label: BiologicalProcess
-        name: Cell wall biogenesis
-    -   id: GO:0008219
-        label: BiologicalProcess
-        name: Cell death
-    -   id: NCBITaxon:1280
-        label: OrganismTaxon
-        name: Staphylococcus aureus
-    -   id: MESH:D013203
-        label: Disease
-        name: Infection due to Staphylococcus aureus
-    reference: https://go.drugbank.com/drugs/DB01150#mechanismofaction http://www.antimicrobe.org/drugpopup/Cefprozil.htm
--   directed: true
-    graph:
-        drug: Citalopram
-        drugbank: DB:DB00215
-        drug_mesh: MESH:D015283
-        disease: Depressive disorder
-        disease_mesh: MESH:D003866
-    links:
-    -   key: decreases activity of
-        source: MESH:D015283
-        target: UniProt:P31645
-    -   key: negatively regulates
-        source: UniProt:P31645
-        target: GO:0051610
-    -   key: located in
-        source: GO:0051610
-        target: GO:0043083
-    -   key: correlated with
-        source: GO:0043083
-        target: MESH:D003866
-    multigraph: true
-    nodes:
-    -   id: MESH:D015283
-        label: Drug
-        name: Citalopram
-    -   id: UniProt:P31645
-        label: Protein
-        name: Solute carrier family 6 member 4, SLC6A4
-    -   id: GO:0051610
-        label: BiologicalProcess
-        name: Serotonin uptake
-    -   id: GO:0043083
-        label: CellularComponent
-        name: Synaptic cleft
-    -   id: MESH:D003866
-        label: Disease
-        name: Depressive disorder
-    reference: https://go.drugbank.com/drugs/DB00215#mechanismofaction https://pubchem.ncbi.nlm.nih.gov/compound/Citalopram#section=Pharmacology-and-Biochemistry
--   directed: true
-    graph:
-        drug: Citalopram
-        drugbank: DB:DB00215
-        drug_mesh: MESH:D015283
-        disease: Major depressive disorder
-        disease_mesh: MESH:D003865
-    links:
-    -   key: decreases activity of
-        source: MESH:D015283
-        target: UniProt:P31645
-    -   key: negatively regulates
-        source: UniProt:P31645
-        target: GO:0051610
-    -   key: located in
-        source: GO:0051610
-        target: GO:0043083
-    -   key: correlated with
-        source: GO:0043083
-        target: MESH:D003865
-    multigraph: true
-    nodes:
-    -   id: MESH:D015283
-        label: Drug
-        name: Citalopram
-    -   id: UniProt:P31645
-        label: Protein
-        name: Solute carrier family 6 member 4, SLC6A4
-    -   id: GO:0051610
-        label: BiologicalProcess
-        name: Serotonin uptake
-    -   id: GO:0043083
-        label: CellularComponent
-        name: Synaptic cleft
-    -   id: MESH:D003865
-        label: Disease
-        name: Major depressive disorder
-    reference: https://go.drugbank.com/drugs/DB00215#mechanismofaction https://pubchem.ncbi.nlm.nih.gov/compound/Citalopram#section=Pharmacology-and-Biochemistry
-
--   directed: true
-    graph:
-        drug: Nisoldipine
-        drugbank: DB:DB00401
-        drug_mesh: MESH:D015737
-        disease: Hypertensive disorder
-        disease_mesh: MESH:D006973
-    links:
-    -   key: decreases activity of
-        source: MESH:D015737
-        target: InterPro:IPR031649
-    -   key: decreases abundance of
-        source: InterPro:IPR031649
-        target: MESH:D002118
-    -   key: negatively regulates
-        source: MESH:D002118
-        target: GO:0006939
-    -   key: causes
-        source: GO:0006939
-        target: GO:0042311
-    -   key: prevents
-        source: GO:0042311
-        target: MESH:D006973
-    multigraph: true
-    nodes:
-    -   id: MESH:D015737
-        label: Drug
-        name: Nisoldipine
-    -   id: InterPro:IPR031649
-        label: GeneFamily
-        name: L-type calcium channels
-    -   id: MESH:D002118
-        label: ChemicalSubstance
-        name: Calcium
-    -   id: GO:0006939
-        label: BiologicalProcess
-        name: Smooth muscle contraction
-    -   id: GO:0042311
-        label: BiologicalProcess
-        name: Vasodilation
-    -   id: MESH:D006973
-        label: Disease
-        name: Hypertensive disorder
-    reference: https://go.drugbank.com/drugs/DB00401#mechanismofaction https://pubchem.ncbi.nlm.nih.gov/compound/Nisoldipine#section=Pharmacology-and-Biochemistry
--   directed: true
-    graph:
-        drug: Paliperidone
-        drugbank: DB:DB01267
-        drug_mesh: NULL
-        disease: Schizoaffective disorder
-        disease_mesh: MESH:D011618
-    links:
-    -   key: decreases activity of
-        source: DB:DB01267
-        target: UniProt:P35348
-    -   key: positively regulates
-        source: UniProt:P35348
-        target: REACT:R-HSA-162582
-    -   key: decreases activity of
-        source: DB:DB01267
-        target: UniProt:P08913
-    -   key: positively regulates
-        source: UniProt:P08913
-        target: REACT:R-HSA-162582
-    -   key: decreases activity of
-        source: DB:DB01267
-        target: UniProt:P35367
-    -   key: positively regulates
-        source: UniProt:P35367
-        target: REACT:R-HSA-162582
-    -   key: decreases activity of
-        source: DB:DB01267
-        target: UniProt:P28223
-    -   key: positively regulates
-        source: UniProt:P28223
-        target: REACT:R-HSA-162582
-    -   key: decreases activity of
-        source: DB:DB01267
-        target: UniProt:P14416
-    -   key: positively regulates
-        source: UniProt:P14416
-        target: REACT:R-HSA-162582
-    -   key: correlated with
-        source: REACT:R-HSA-162582
-        target: MESH:D011618
-    multigraph: true
-    nodes:
-    -   id: DB:DB01267
-        label: Drug
-        name: Paliperidone
-    -   id: UniProt:P35348
-        label: Protein
-        name: Alpha 1 adrenergic receptor
-    -   id: UniProt:P08913
-        label: Protein
-        name: Alpha 2 adrenergic receptor
-    -   id: UniProt:P35367
-        label: Protein
-        name: Histamine H1 receptor
-    -   id: UniProt:P28223
-        label: Protein
-        name: 5-hydroxytryptamine receptor 2A
-    -   id: UniProt:P14416
-        label: Protein
-        name: D(2) dopamine receptor
-    -   id: REACT:R-HSA-162582
-        label: Pathway
-        name: Signal transduction
-    -   id: MESH:D011618
-        label: Disease
-        name: Schizoaffective disorder
-    reference: https://go.drugbank.com/drugs/DB01267#mechanismofaction https://pubchem.ncbi.nlm.nih.gov/compound/Paliperidone
+