From 71e73a841b088ed318f69545abe06277ed0de097 Mon Sep 17 00:00:00 2001 From: dede2021 <77809650+dede2021@users.noreply.github.com> Date: Fri, 21 May 2021 20:38:15 +0100 Subject: [PATCH 1/2] Group 99 curated - corrections + new fork --- submission.yaml | 809 +++++++++++++++++++++++++++++++++++++++++++++++- 1 file changed, 808 insertions(+), 1 deletion(-) diff --git a/submission.yaml b/submission.yaml index 8b1378917..4fd4064aa 100644 --- a/submission.yaml +++ b/submission.yaml @@ -1 +1,808 @@ - +- directed: true + graph: + disease: Rhinitis + disease_mesh: MESH:D012220 + drug: Beclomethasone dipropionate + drug_mesh: null + drugbank: DB:DB00394 + links: + - key: has metabolite + source: DB:DB00394 + target: CHEBI:3001 + - key: positively regulates + source: CHEBI:3001 + target: UniProt:P04150 + - key: negatively regulates + source: UniProt:P04150 + target: GO:0006954 + - key: positively correlated with + source: GO:0006954 + target: MESH:D012220 + multigraph: true + nodes: + - id: DB:DB00394 + label: Drug + name: Beclomethasone dipropionate + - id: CHEBI:3001 + label: ChemicalSubstance + name: beclomethasone + alt_names: + - Beclomethasone 17-monopropionate + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: GO:0006954 + label: BiologicalProcess + name: inflammatory response + - id: MESH:D012220 + label: Disease + name: Rhinitis + reference: + - https://go.drugbank.com/drugs/DB00394 + - https://en.wikipedia.org/wiki/Beclometasone#Pharmacology + comment: Beclomethasone dipropionate is a prodrug, which gives rise to Beclomethasone (MESH:D001507), also known as Beclomethasone 17-monopropionate (https://pubchem.ncbi.nlm.nih.gov/compound/17-BMP). +- directed: true + graph: + disease: Vasomotor rhinitis + disease_mesh: MESH:D012223 + drug: Beclomethasone dipropionate + drug_mesh: null + drugbank: DB:DB00394 + links: + - key: has metabolite + source: DB:DB00394 + target: CHEBI:3001 + - key: positively regulates + source: CHEBI:3001 + target: UniProt:P04150 + - key: negatively regulates + source: UniProt:P04150 + target: GO:0042311 + - key: positively correlated with + source: GO:0042311 + target: MESH:D012223 + multigraph: true + nodes: + - id: DB:DB00394 + label: Drug + name: Beclomethasone dipropionate + - id: CHEBI:3001 + label: ChemicalSubstance + name: beclomethasone + alt_names: + - Beclomethasone 17-monopropionate + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: GO:0042311 + label: BiologicalProcess + name: vasodilation + - id: MESH:D012223 + label: Disease + name: Vasomotor rhinitis + reference: + - https://go.drugbank.com/drugs/DB00394 + - https://en.wikipedia.org/wiki/Corticosteroid#Classes + comment: Beclomethasone dipropionate is a prodrug, giving rise to Beclomethasone (MESH:D001507), also known as Beclomethasone 17-monopropionate (https://pubchem.ncbi.nlm.nih.gov/compound/17-BMP). +- directed: true + graph: + disease: Nasal polyp + disease_mesh: MESH:D009298 + drug: Beclomethasone dipropionate + drug_mesh: null + drugbank: DB:DB00394 + links: + - key: has metabolite + source: DB:DB00394 + target: CHEBI:3001 + - key: positively regulates + source: CHEBI:3001 + target: UniProt:P04150 + - key: negatively regulates + source: UniProt:P04150 + target: GO:0006954 + - key: positively correlated with + source: GO:0006954 + target: MESH:D009298 + multigraph: true + nodes: + - id: DB:DB00394 + label: Drug + name: Beclomethasone dipropionate + - id: CHEBI:3001 + label: ChemicalSubstance + name: beclomethasone + alt_names: + - Beclomethasone 17-monopropionate + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: GO:0006954 + label: BiologicalProcess + name: inflammatory response + - id: MESH:D009298 + label: Disease + name: Nasal polyp + reference: + - https://go.drugbank.com/drugs/DB00394 + - https://en.wikipedia.org/wiki/Beclometasone#Pharmacology + - https://en.wikipedia.org/wiki/Nasal_polyp#Pathophysiology + comment: Beclomethasone dipropionate is a prodrug, giving rise to Beclomethasone (MESH:D001507), also known as Beclomethasone 17-monopropionate (https://pubchem.ncbi.nlm.nih.gov/compound/17-BMP). +- directed: true + graph: + disease: Asthma + disease_mesh: MESH:D001249 + drug: Beclomethasone dipropionate + drug_mesh: null + drugbank: DB:DB00394 + links: + - key: has metabolite + source: DB:DB00394 + target: CHEBI:3001 + - key: positively regulates + source: CHEBI:3001 + target: UniProt:P04150 + - key: negatively regulates + source: UniProt:P04150 + target: GO:0006954 + - key: positively correlated with + source: GO:0006954 + target: MESH:D001249 + multigraph: true + nodes: + - id: DB:DB00394 + label: Drug + name: Beclomethasone dipropionate + - id: CHEBI:3001 + label: ChemicalSubstance + name: beclomethasone + alt_names: + - Beclomethasone 17-monopropionate + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: GO:0006954 + label: BiologicalProcess + name: inflammatory response + - id: MESH:D001249 + label: Disease + name: Asthma + reference: + - https://go.drugbank.com/drugs/DB00394 + - https://en.wikipedia.org/wiki/Beclometasone#Pharmacology + comment: Beclomethasone dipropionate is a prodrug, giving rise to Beclomethasone (MESH:D001507), also known as Beclomethasone 17-monopropionate (https://pubchem.ncbi.nlm.nih.gov/compound/17-BMP). +- directed: true + graph: + disease: Allergic rhinitis + disease_mesh: MESH:D065631 + drug: Beclomethasone dipropionate + drug_mesh: null + drugbank: DB:DB00394 + links: + - key: has metabolite + source: DB:DB00394 + target: CHEBI:3001 + - key: positively regulates + source: CHEBI:3001 + target: UniProt:P04150 + - key: negatively regulates + source: UniProt:P04150 + target: GO:0006954 + - key: positively correlated with + source: GO:0006954 + target: MESH:D065631 + multigraph: true + nodes: + - id: DB:DB00394 + label: Drug + name: Beclomethasone dipropionate + - id: CHEBI:3001 + label: ChemicalSubstance + name: beclomethasone + alt_names: + - Beclomethasone 17-monopropionate + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: GO:0006954 + label: BiologicalProcess + name: inflammatory response + - id: MESH:D065631 + label: Disease + name: Allergic rhinitis + reference: + - https://go.drugbank.com/drugs/DB00394 + - https://en.wikipedia.org/wiki/Beclometasone#Pharmacology + comment: Beclomethasone dipropionate is a prodrug, giving rise to Beclomethasone (MESH:D001507), also known as Beclomethasone 17-monopropionate (https://pubchem.ncbi.nlm.nih.gov/compound/17-BMP). +- directed: true + graph: + disease: Herpes zoster + disease_mesh: MESH:D006562 + drug: famciclovir + drug_mesh: MESH:D000077595 + drugbank: DB:DB00426 + links: + - key: has metabolite + source: MESH:D000077595 + target: DB:DB00299 + - key: negatively regulates + source: DB:DB00299 + target: UniProt:P09252 + - key: positively regulates + source: UniProt:P09252 + target: GO:0039693 + - key: in taxon + source: GO:0039693 + target: NCBITaxon:10335 + - key: causes + source: NCBITaxon:10335 + target: MESH:D006562 + multigraph: true + nodes: + - id: MESH:D000077595 + label: Drug + name: famciclovir + - id: DB:DB00299 + label: Drug + name: Penciclovir + - id: UniProt:P09252 + label: Protein + name: DNA polymerase catalytic subunit + - id: GO:0039693 + label: BiologicalProcess + name: viral DNA genome replication + - id: NCBITaxon:10335 + label: OrganismTaxon + name: Human alphaherpesvirus 3 + - id: MESH:D006562 + label: Disease + name: Herpes zoster + reference: https://go.drugbank.com/drugs/DB00426 +- directed: true + graph: + disease: Tinea pedis + disease_mesh: MESH:D014008 + drug: sulconazole + drug_mesh: MESH:C033308 + drugbank: DB:DB06820 + links: + - key: negatively regulates + source: MESH:C033308 + target: UniProt:P10613 + - key: positively regulates + source: UniProt:P10613 + target: GO:0006696 + - key: in taxon + source: GO:0006696 + target: NCBITaxon:237561 + - key: causes + source: NCBITaxon:237561 + target: MESH:D014008 + multigraph: true + nodes: + - id: MESH:C033308 + label: Drug + name: sulconazole + - id: UniProt:P10613 + label: Protein + name: Lanosterol 14-alpha demethylase + - id: GO:0006696 + label: BiologicalProcess + name: ergosterol biosynthetic process + - id: NCBITaxon:237561 + label: OrganismTaxon + name: Candida albicans SC5314 + - id: MESH:D014008 + label: Disease + name: Tinea pedis + reference: https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1221/ +- directed: true + graph: + disease: Pityriasis versicolor + disease_mesh: MESH:D014010 + drug: sulconazole + drug_mesh: MESH:C033308 + drugbank: DB:DB06820 + links: + - key: negatively regulates + source: MESH:C033308 + target: UniProt:P10613 + - key: positively regulates + source: UniProt:P10613 + target: GO:0006696 + - key: in taxon + source: GO:0006696 + target: NCBITaxon:237561 + - key: causes + source: NCBITaxon:237561 + target: MESH:D014010 + multigraph: true + nodes: + - id: MESH:C033308 + label: Drug + name: sulconazole + - id: UniProt:P10613 + label: Protein + name: Lanosterol 14-alpha demethylase + - id: GO:0006696 + label: BiologicalProcess + name: ergosterol biosynthetic process + - id: NCBITaxon:237561 + label: OrganismTaxon + name: Candida albicans SC5314 + - id: MESH:D014010 + label: Disease + name: Pityriasis versicolor + reference: https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1221/ +- directed: true + graph: + disease: Thromboembolic disorder + disease_mesh: MESH:D013923 + drug: warfarin + drug_mesh: MESH:D014859 + drugbank: DB:DB00682 + links: + - key: negatively regulates + source: MESH:D014859 + target: UniProt:Q9BQB6 + - key: positively regulates + source: UniProt:Q9BQB6 + target: GO:0007596 + - key: correlated with + source: GO:0007596 + target: GO:0072378 + - key: affects risk for + source: GO:0072378 + target: MESH:D013923 + multigraph: true + nodes: + - id: MESH:D014859 + label: Drug + name: warfarin + - id: UniProt:Q9BQB6 + label: Protein + name: Vitamin K epoxide reductase complex subunit 1 + - id: GO:0007596 + label: BiologicalProcess + name: blood coagulation + - id: GO:0072378 + label: BiologicalProcess + name: blood coagulation, fibrin clot formation + - id: MESH:D013923 + label: Disease + name: Thromboembolic disorder + reference: + - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1464/ + - https://go.drugbank.com/drugs/DB00682 +- directed: true + graph: + disease: Cerebral embolism + disease_mesh: MESH:D020766 + drug: warfarin + drug_mesh: MESH:D014859 + drugbank: DB:DB00682 + links: + - key: negatively regulates + source: MESH:D014859 + target: UniProt:Q9BQB6 + - key: positively regulates + source: UniProt:Q9BQB6 + target: GO:0007596 + - key: correlated with + source: GO:0007596 + target: GO:0072378 + - key: affects risk for + source: GO:0072378 + target: MESH:D020766 + multigraph: true + nodes: + - id: MESH:D014859 + label: Drug + name: warfarin + - id: UniProt:Q9BQB6 + label: Protein + name: Vitamin K epoxide reductase complex subunit 1 + - id: GO:0007596 + label: BiologicalProcess + name: blood coagulation + - id: GO:0072378 + label: BiologicalProcess + name: blood coagulation, fibrin clot formation + - id: MESH:D020766 + label: Disease + name: Cerebral embolism + reference: + - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1464/ + - https://go.drugbank.com/drugs/DB00682 +- directed: true + graph: + disease: Deep venous thrombosis + disease_mesh: MESH:D020246 + drug: warfarin + drug_mesh: MESH:D014859 + drugbank: DB:DB00682 + links: + - key: negatively regulates + source: MESH:D014859 + target: UniProt:Q9BQB6 + - key: positively regulates + source: UniProt:Q9BQB6 + target: GO:0007596 + - key: correlated with + source: GO:0007596 + target: GO:0072378 + - key: affects risk for + source: GO:0072378 + target: MESH:D020246 + multigraph: true + nodes: + - id: MESH:D014859 + label: Drug + name: warfarin + - id: UniProt:Q9BQB6 + label: Protein + name: Vitamin K epoxide reductase complex subunit 1 + - id: GO:0007596 + label: BiologicalProcess + name: blood coagulation + - id: GO:0072378 + label: BiologicalProcess + name: blood coagulation, fibrin clot formation + - id: MESH:D020246 + label: Disease + name: Deep venous thrombosis + reference: + - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1464/ + - https://go.drugbank.com/drugs/DB00682 +- directed: true + graph: + disease: Thrombosis + disease_mesh: MESH:D013927 + drug: warfarin + drug_mesh: MESH:D014859 + drugbank: DB:DB00682 + links: + - key: negatively regulates + source: MESH:D014859 + target: UniProt:Q9BQB6 + - key: positively regulates + source: UniProt:Q9BQB6 + target: GO:0007596 + - key: correlated with + source: GO:0007596 + target: GO:0072378 + - key: affects risk for + source: GO:0072378 + target: MESH:D013927 + multigraph: true + nodes: + - id: MESH:D014859 + label: Drug + name: warfarin + - id: UniProt:Q9BQB6 + label: Protein + name: Vitamin K epoxide reductase complex subunit 1 + - id: GO:0007596 + label: BiologicalProcess + name: blood coagulation + - id: GO:0072378 + label: BiologicalProcess + name: blood coagulation, fibrin clot formation + - id: MESH:D013927 + label: Disease + name: Thrombosis + reference: + - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1464/ + - https://go.drugbank.com/drugs/DB00682 +- directed: true + graph: + disease: Pulmonary thromboembolism + disease_mesh: MESH:D011655 + drug: warfarin + drug_mesh: MESH:D014859 + drugbank: DB:DB00682 + links: + - key: negatively regulates + source: MESH:D014859 + target: UniProt:Q9BQB6 + - key: positively regulates + source: UniProt:Q9BQB6 + target: GO:0007596 + - key: correlated with + source: GO:0007596 + target: GO:0072378 + - key: affects risk for + source: GO:0072378 + target: MESH:D011655 + multigraph: true + nodes: + - id: MESH:D014859 + label: Drug + name: warfarin + - id: UniProt:Q9BQB6 + label: Protein + name: Vitamin K epoxide reductase complex subunit 1 + - id: GO:0007596 + label: BiologicalProcess + name: blood coagulation + - id: GO:0072378 + label: BiologicalProcess + name: blood coagulation, fibrin clot formation + - id: MESH:D011655 + label: Disease + name: Pulmonary thromboembolism + reference: + - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1464/ + - https://go.drugbank.com/drugs/DB00682 +- directed: true + graph: + disease: Pulmonary thromboembolism + disease_mesh: MESH:D011655 + drug: urokinase + drug_mesh: MESH:D014568 + drugbank: DB:DB00013 + links: + - key: positively regulates + source: MESH:D014568 + target: UniProt:P00747 + - key: positively regulates + source: UniProt:P00747 + target: GO:0042730 + - key: negatively correlated with + source: GO:0042730 + target: MESH:D011655 + multigraph: true + nodes: + - id: MESH:D014568 + label: Drug + name: urokinase + - id: UniProt:P00747 + label: Protein + name: Plasminogen + - id: GO:0042730 + label: BiologicalProcess + name: fibrinolysis + - id: MESH:D011655 + label: Disease + name: Pulmonary thromboembolism + reference: + - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201420/ + - https://go.drugbank.com/drugs/DB00013 +- directed: true + graph: + disease: Spasm of cerebral arteries + disease_mesh: MESH:D020301 + drug: fasudil + drug_mesh: MESH:C049347 + drugbank: DB:DB08162 + links: + - key: has metabolite + source: MESH:C049347 + target: DB:DB04707 + - key: decreases activity of + source: DB:DB04707 + target: UniProt:Q13464 + - key: positively regulates + source: UniProt:Q13464 + target: GO:0014829 + - key: positively correlated with + source: GO:0014829 + target: MESH:D020301 + multigraph: true + nodes: + - id: MESH:C049347 + label: Drug + name: fasudil + - id: DB:DB04707 + label: ChemicalSubstance + name: Hydroxyfasudil + - id: UniProt:Q13464 + label: Protein + name: Rho-associated protein kinase 1 + - id: GO:0014829 + label: BiologicalProcess + name: vascular associated smooth muscle contraction + - id: MESH:D020301 + label: Disease + name: Spasm of cerebral arteries + reference: + - https://en.wikipedia.org/wiki/Fasudil + - https://en.wikipedia.org/wiki/Rho_kinase_inhibitor + - https://go.drugbank.com/drugs/DB04707#BE0001016 +- directed: true + graph: + disease: Malignant tumor of colon + disease_mesh: MESH:D003110 + drug: tipiracil + drug_mesh: MESH:C000613754 + drugbank: DB:DB09343 + links: + - key: decreases activity of + source: MESH:C000613754 + target: UniProt:P19971 + - key: positively regulates + source: UniProt:P19971 + target: GO:0001525 + - key: positively correlated with + source: GO:0001525 + target: MESH:D003110 + multigraph: true + nodes: + - id: MESH:C000613754 + label: Drug + name: tipiracil + - id: UniProt:P19971 + label: Protein + name: Thymidine phosphorylase + - id: GO:0001525 + label: BiologicalProcess + name: angiogenesis + - id: MESH:D003110 + label: Disease + name: Malignant tumor of colon + reference: https://go.drugbank.com/drugs/DB09343 + comment: Tipiracil may also play its anti-neoplastic role indirectly when admnistered in combination with Trifluridine (DB:DB00432). In this case, tipiracil will prevent trifluridine breakdown, thus increasing its bioavailability and boosting its systemiic presence (https://en.wikipedia.org/wiki/Trifluridine/tipiracil). +- directed: true + graph: + disease: Iron deficiency anemia + disease_mesh: MESH:D018798 + drug: ferrous gluconate + drug_mesh: MESH:C011819 + drugbank: DB:DB09517 + links: + - key: increases abundance of + source: MESH:C011819 + target: CHEBI:18248 + - key: correlated with + source: CHEBI:18248 + target: GO:0055072 + - key: negatively correlated with + source: GO:0055072 + target: MESH:D018798 + multigraph: true + nodes: + - id: MESH:C011819 + label: Drug + name: ferrous gluconate + - id: CHEBI:18248 + label: ChemicalSubstance + name: iron atom + - id: GO:0055072 + label: BiologicalProcess + name: iron ion homeostasis + - id: MESH:D018798 + label: Disease + name: Iron deficiency anemia + reference: https://en.wikipedia.org/wiki/Iron(II)_gluconate +- directed: true + graph: + disease: Parkinson's disease + disease_mesh: MESH:D010300 + drug: carbidopa + drug_mesh: MESH:D002230 + drugbank: DB:DB00190 + links: + - key: negatively regulates + source: MESH:D002230 + target: UniProt:P20711 + - key: positively regulates + source: UniProt:P20711 + target: GO:1903184 + - key: positively correlated with + source: GO:1903184 + target: HP:0002017 + - key: manifestation of + source: HP:0002017 + target: MESH:D010300 + multigraph: true + nodes: + - id: MESH:D002230 + label: Drug + name: carbidopa + - id: UniProt:P20711 + label: Protein + name: Aromatic-L-amino-acid decarboxylase + - id: GO:1903184 + label: BiologicalProcess + name: L-dopa metabolic process + - id: HP:0002017 + label: PhenotypicFeature + name: Nausea and vomiting + - id: MESH:D010300 + label: Disease + name: Parkinson's disease + reference: + - https://go.drugbank.com/drugs/DB00190 + - https://www.ebmconsult.com/articles/carbidopa-levodopa-parkinson-disease + - https://en.wikipedia.org/wiki/L-DOPA#Medical_use + - https://en.wikipedia.org/wiki/Aromatic_L-amino_acid_decarboxylase_inhibitor + - https://en.wikipedia.org/wiki/Carbidopa/levodopa#Mechanism_of_action + comment: The drug has no anti-parkinson activity per se. It is admnistered in combination with levodopa to prevent levodopa degradation to dopamine in extracerebral tissue, thereby decreasing the peripheral side effects of levodopa. +- directed: true + graph: + disease: Parkinsonism + disease_mesh: MESH:D020734 + drug: carbidopa + drug_mesh: MESH:D002230 + drugbank: DB:DB00190 + links: + - key: negatively regulates + source: MESH:D002230 + target: UniProt:P20711 + - key: positively regulates + source: UniProt:P20711 + target: GO:1903184 + - key: correlated with + source: GO:1903184 + target: HP:0002017 + - key: manifestation of + source: HP:0002017 + target: MESH:D020734 + multigraph: true + nodes: + - id: MESH:D002230 + label: Drug + name: carbidopa + - id: UniProt:P20711 + label: Protein + name: Aromatic-L-amino-acid decarboxylase + - id: GO:1903184 + label: BiologicalProcess + name: L-dopa metabolic process + - id: HP:0002017 + label: PhenotypicFeature + name: Nausea and vomiting + - id: MESH:D020734 + label: Disease + name: Parkinsonism + reference: + - https://go.drugbank.com/drugs/DB00190 + - https://www.ebmconsult.com/articles/carbidopa-levodopa-parkinson-disease + - https://en.wikipedia.org/wiki/L-DOPA#Medical_use + - https://en.wikipedia.org/wiki/Aromatic_L-amino_acid_decarboxylase_inhibitor + - https://en.wikipedia.org/wiki/Carbidopa/levodopa#Mechanism_of_action + comment: The drug has no anti-parkinson activity per se. It is admnistered in combination with levodopa to prevent levodopa degradation to dopamine in extracerebral tissue, thereby decreasing the peripheral side effects of levodopa. +- directed: true + graph: + disease: Postencephalitic parkinsonism + disease_mesh: MESH:D010301 + drug: carbidopa + drug_mesh: MESH:D002230 + drugbank: DB:DB00190 + links: + - key: negatively regulates + source: MESH:D002230 + target: UniProt:P20711 + - key: positively regulates + source: UniProt:P20711 + target: GO:1903184 + - key: correlated with + source: GO:1903184 + target: HP:0002017 + - key: manifestation of + source: HP:0002017 + target: MESH:D010301 + multigraph: true + nodes: + - id: MESH:D002230 + label: Drug + name: carbidopa + - id: UniProt:P20711 + label: Protein + name: Aromatic-L-amino-acid decarboxylase + - id: GO:1903184 + label: BiologicalProcess + name: L-dopa metabolic process + - id: HP:0002017 + label: PhenotypicFeature + name: Nausea and vomiting + - id: MESH:D010301 + label: Disease + name: Postencephalitic parkinsonism + reference: + - https://go.drugbank.com/drugs/DB00190 + - https://www.ebmconsult.com/articles/carbidopa-levodopa-parkinson-disease + - https://en.wikipedia.org/wiki/L-DOPA#Medical_use + - https://en.wikipedia.org/wiki/Aromatic_L-amino_acid_decarboxylase_inhibitor + - https://en.wikipedia.org/wiki/Carbidopa/levodopa#Mechanism_of_action + comment: The drug has no anti-parkinson activity per se. It is admnistered in combination with levodopa to prevent levodopa degradation to dopamine in extracerebral tissue, thereby decreasing the peripheral side effects of levodopa. From 3d2d401ad130d3059758f08ff64c297e61bbaeb0 Mon Sep 17 00:00:00 2001 From: TanskaAnnna Date: Mon, 24 May 2021 08:28:29 +0000 Subject: [PATCH 2/2] Commit from GitHub Actions (Update Indications on Merge) --- indication_paths.json | 1310 +++++++++++++++++++++++++++++++++++++++++ indication_paths.yaml | 847 ++++++++++++++++++++++++++ submission.yaml | 809 +------------------------ 3 files changed, 2158 insertions(+), 808 deletions(-) diff --git a/indication_paths.json b/indication_paths.json index 4e8cef0cf..c6e9caf50 100644 --- a/indication_paths.json +++ b/indication_paths.json @@ -197598,5 +197598,1315 @@ "https://go.drugbank.com/drugs/DB01277", "https://pubmed.ncbi.nlm.nih.gov/19198769/" ] + }, + { + "comment": "Beclomethasone dipropionate is a prodrug, which gives rise to Beclomethasone (MESH:D001507), also known as Beclomethasone 17-monopropionate (https://pubchem.ncbi.nlm.nih.gov/compound/17-BMP).", + "directed": true, + "graph": { + "_id": "DB00394_MESH_D012220_1", + "disease": "Rhinitis", + "disease_mesh": "MESH:D012220", + "drug": "Beclomethasone dipropionate", + "drug_mesh": null, + "drugbank": "DB:DB00394" + }, + "links": [ + { + "key": "has metabolite", + "source": "DB:DB00394", + "target": "CHEBI:3001" + }, + { + "key": "positively regulates", + "source": "CHEBI:3001", + "target": "UniProt:P04150" + }, + { + "key": "negatively regulates", + "source": "UniProt:P04150", + "target": "GO:0006954" + }, + { + "key": "positively correlated with", + "source": "GO:0006954", + "target": "MESH:D012220" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "DB:DB00394", + "label": "Drug", + "name": "Beclomethasone dipropionate" + }, + { + "alt_names": [ + "Beclomethasone 17-monopropionate" + ], + "id": "CHEBI:3001", + "label": "ChemicalSubstance", + "name": "beclomethasone" + }, + { + "id": "UniProt:P04150", + "label": "Protein", + "name": "Glucocorticoid receptor" + }, + { + "id": "GO:0006954", + "label": "BiologicalProcess", + "name": "inflammatory response" + 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+ { + "key": "decreases activity of", + "source": "DB:DB04707", + "target": "UniProt:Q13464" + }, + { + "key": "positively regulates", + "source": "UniProt:Q13464", + "target": "GO:0014829" + }, + { + "key": "positively correlated with", + "source": "GO:0014829", + "target": "MESH:D020301" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:C049347", + "label": "Drug", + "name": "fasudil" + }, + { + "id": "DB:DB04707", + "label": "ChemicalSubstance", + "name": "Hydroxyfasudil" + }, + { + "id": "UniProt:Q13464", + "label": "Protein", + "name": "Rho-associated protein kinase 1" + }, + { + "id": "GO:0014829", + "label": "BiologicalProcess", + "name": "vascular associated smooth muscle contraction" + }, + { + "id": "MESH:D020301", + "label": "Disease", + "name": "Spasm of cerebral arteries" + } + ], + "reference": [ + "https://en.wikipedia.org/wiki/Fasudil", + "https://en.wikipedia.org/wiki/Rho_kinase_inhibitor", + "https://go.drugbank.com/drugs/DB04707#BE0001016" + ] + }, + { + "comment": "Tipiracil may also play its anti-neoplastic role indirectly when admnistered in combination with Trifluridine (DB:DB00432). In this case, tipiracil will prevent trifluridine breakdown, thus increasing its bioavailability and boosting its systemiic presence (https://en.wikipedia.org/wiki/Trifluridine/tipiracil).", + "directed": true, + "graph": { + "_id": "DB09343_MESH_D003110_1", + "disease": "Malignant tumor of colon", + "disease_mesh": "MESH:D003110", + "drug": "tipiracil", + "drug_mesh": "MESH:C000613754", + "drugbank": "DB:DB09343" + }, + "links": [ + { + "key": "decreases activity of", + "source": "MESH:C000613754", + "target": "UniProt:P19971" + }, + { + "key": "positively regulates", + "source": "UniProt:P19971", + "target": "GO:0001525" + }, + { + "key": "positively correlated with", + "source": "GO:0001525", + "target": "MESH:D003110" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:C000613754", + "label": "Drug", + "name": "tipiracil" + }, + { + "id": "UniProt:P19971", + "label": "Protein", + "name": "Thymidine phosphorylase" + }, + { + "id": "GO:0001525", + "label": "BiologicalProcess", + "name": "angiogenesis" + }, + { + "id": "MESH:D003110", + "label": "Disease", + "name": "Malignant tumor of colon" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB09343" + ] + }, + { + "directed": true, + "graph": { + "_id": "DB09517_MESH_D018798_1", + "disease": "Iron deficiency anemia", + "disease_mesh": "MESH:D018798", + "drug": "ferrous gluconate", + "drug_mesh": "MESH:C011819", + "drugbank": "DB:DB09517" + }, + "links": [ + { + "key": "increases abundance of", + "source": "MESH:C011819", + "target": "CHEBI:18248" + }, + { + "key": "correlated with", + "source": "CHEBI:18248", + "target": "GO:0055072" + }, + { + "key": "negatively correlated with", + "source": "GO:0055072", + "target": "MESH:D018798" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:C011819", + "label": "Drug", + "name": "ferrous gluconate" + }, + { + "id": "CHEBI:18248", + "label": "ChemicalSubstance", + "name": "iron atom" + }, + { + "id": "GO:0055072", + "label": "BiologicalProcess", + "name": "iron ion homeostasis" + }, + { + "id": "MESH:D018798", + "label": "Disease", + "name": "Iron deficiency anemia" + } + ], + "reference": [ + "https://en.wikipedia.org/wiki/Iron(II)_gluconate" + ] + }, + { + "comment": "The drug has no anti-parkinson activity per se. It is admnistered in combination with levodopa to prevent levodopa degradation to dopamine in extracerebral tissue, thereby decreasing the peripheral side effects of levodopa.", + "directed": true, + "graph": { + "_id": "DB00190_MESH_D010300_1", + "disease": "Parkinson's disease", + "disease_mesh": "MESH:D010300", + "drug": "carbidopa", + "drug_mesh": "MESH:D002230", + "drugbank": "DB:DB00190" + }, + "links": [ + { + "key": "negatively regulates", + "source": "MESH:D002230", + "target": "UniProt:P20711" + }, + { + "key": "positively regulates", + "source": "UniProt:P20711", + "target": "GO:1903184" + }, + { + "key": "positively correlated with", + "source": "GO:1903184", + "target": "HP:0002017" + }, + { + "key": "manifestation of", + "source": "HP:0002017", + "target": "MESH:D010300" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:D002230", + "label": "Drug", + "name": "carbidopa" + }, + { + "id": "UniProt:P20711", + "label": "Protein", + "name": "Aromatic-L-amino-acid decarboxylase" + }, + { + "id": "GO:1903184", + "label": "BiologicalProcess", + "name": "L-dopa metabolic process" + }, + { + "id": "HP:0002017", + "label": "PhenotypicFeature", + "name": "Nausea and vomiting" + }, + { + "id": "MESH:D010300", + "label": "Disease", + "name": "Parkinson's disease" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB00190", + "https://www.ebmconsult.com/articles/carbidopa-levodopa-parkinson-disease", + "https://en.wikipedia.org/wiki/L-DOPA#Medical_use", + "https://en.wikipedia.org/wiki/Aromatic_L-amino_acid_decarboxylase_inhibitor", + "https://en.wikipedia.org/wiki/Carbidopa/levodopa#Mechanism_of_action" + ] + }, + { + "comment": "The drug has no anti-parkinson activity per se. It is admnistered in combination with levodopa to prevent levodopa degradation to dopamine in extracerebral tissue, thereby decreasing the peripheral side effects of levodopa.", + "directed": true, + "graph": { + "_id": "DB00190_MESH_D020734_1", + "disease": "Parkinsonism", + "disease_mesh": "MESH:D020734", + "drug": "carbidopa", + "drug_mesh": "MESH:D002230", + "drugbank": "DB:DB00190" + }, + "links": [ + { + "key": "negatively regulates", + "source": "MESH:D002230", + "target": "UniProt:P20711" + }, + { + "key": "positively regulates", + "source": "UniProt:P20711", + "target": "GO:1903184" + }, + { + "key": "correlated with", + "source": "GO:1903184", + "target": "HP:0002017" + }, + { + "key": "manifestation of", + "source": "HP:0002017", + "target": "MESH:D020734" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:D002230", + "label": "Drug", + "name": "carbidopa" + }, + { + "id": "UniProt:P20711", + "label": "Protein", + "name": "Aromatic-L-amino-acid decarboxylase" + }, + { + "id": "GO:1903184", + "label": "BiologicalProcess", + "name": "L-dopa metabolic process" + }, + { + "id": "HP:0002017", + "label": "PhenotypicFeature", + "name": "Nausea and vomiting" + }, + { + "id": "MESH:D020734", + "label": "Disease", + "name": "Parkinsonism" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB00190", + "https://www.ebmconsult.com/articles/carbidopa-levodopa-parkinson-disease", + "https://en.wikipedia.org/wiki/L-DOPA#Medical_use", + "https://en.wikipedia.org/wiki/Aromatic_L-amino_acid_decarboxylase_inhibitor", + "https://en.wikipedia.org/wiki/Carbidopa/levodopa#Mechanism_of_action" + ] + }, + { + "comment": "The drug has no anti-parkinson activity per se. It is admnistered in combination with levodopa to prevent levodopa degradation to dopamine in extracerebral tissue, thereby decreasing the peripheral side effects of levodopa.", + "directed": true, + "graph": { + "_id": "DB00190_MESH_D010301_1", + "disease": "Postencephalitic parkinsonism", + "disease_mesh": "MESH:D010301", + "drug": "carbidopa", + "drug_mesh": "MESH:D002230", + "drugbank": "DB:DB00190" + }, + "links": [ + { + "key": "negatively regulates", + "source": "MESH:D002230", + "target": "UniProt:P20711" + }, + { + "key": "positively regulates", + "source": "UniProt:P20711", + "target": "GO:1903184" + }, + { + "key": "correlated with", + "source": "GO:1903184", + "target": "HP:0002017" + }, + { + "key": "manifestation of", + "source": "HP:0002017", + "target": "MESH:D010301" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:D002230", + "label": "Drug", + "name": "carbidopa" + }, + { + "id": "UniProt:P20711", + "label": "Protein", + "name": "Aromatic-L-amino-acid decarboxylase" + }, + { + "id": "GO:1903184", + "label": "BiologicalProcess", + "name": "L-dopa metabolic process" + }, + { + "id": "HP:0002017", + "label": "PhenotypicFeature", + "name": "Nausea and vomiting" + }, + { + "id": "MESH:D010301", + "label": "Disease", + "name": "Postencephalitic parkinsonism" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB00190", + "https://www.ebmconsult.com/articles/carbidopa-levodopa-parkinson-disease", + "https://en.wikipedia.org/wiki/L-DOPA#Medical_use", + "https://en.wikipedia.org/wiki/Aromatic_L-amino_acid_decarboxylase_inhibitor", + "https://en.wikipedia.org/wiki/Carbidopa/levodopa#Mechanism_of_action" + ] } ] \ No newline at end of file diff --git a/indication_paths.yaml b/indication_paths.yaml index 0461cd144..539e436e0 100644 --- a/indication_paths.yaml +++ b/indication_paths.yaml @@ -124198,3 +124198,850 @@ reference: - https://go.drugbank.com/drugs/DB01277 - https://pubmed.ncbi.nlm.nih.gov/19198769/ +- comment: Beclomethasone dipropionate is a prodrug, which gives rise to Beclomethasone + (MESH:D001507), also known as Beclomethasone 17-monopropionate (https://pubchem.ncbi.nlm.nih.gov/compound/17-BMP). + directed: true + graph: + _id: DB00394_MESH_D012220_1 + disease: Rhinitis + disease_mesh: MESH:D012220 + drug: Beclomethasone dipropionate + drug_mesh: null + drugbank: DB:DB00394 + links: + - key: has metabolite + source: DB:DB00394 + target: CHEBI:3001 + - key: positively regulates + source: CHEBI:3001 + target: UniProt:P04150 + - key: negatively regulates + source: UniProt:P04150 + target: GO:0006954 + - key: positively correlated with + source: GO:0006954 + target: MESH:D012220 + multigraph: true + nodes: + - id: DB:DB00394 + label: Drug + name: Beclomethasone dipropionate + - alt_names: + - Beclomethasone 17-monopropionate + id: CHEBI:3001 + label: ChemicalSubstance + name: beclomethasone + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: GO:0006954 + label: BiologicalProcess + name: inflammatory response + - id: MESH:D012220 + label: Disease + name: Rhinitis + reference: + - https://go.drugbank.com/drugs/DB00394 + - https://en.wikipedia.org/wiki/Beclometasone#Pharmacology +- comment: Beclomethasone dipropionate is a prodrug, giving rise to Beclomethasone + (MESH:D001507), also known as Beclomethasone 17-monopropionate (https://pubchem.ncbi.nlm.nih.gov/compound/17-BMP). + directed: true + graph: + _id: DB00394_MESH_D012223_1 + disease: Vasomotor rhinitis + disease_mesh: MESH:D012223 + drug: Beclomethasone dipropionate + drug_mesh: null + drugbank: DB:DB00394 + links: + - key: has metabolite + source: DB:DB00394 + target: CHEBI:3001 + - key: positively regulates + source: CHEBI:3001 + target: UniProt:P04150 + - key: negatively regulates + source: UniProt:P04150 + target: GO:0042311 + - key: positively correlated with + source: GO:0042311 + target: MESH:D012223 + multigraph: true + nodes: + - id: DB:DB00394 + label: Drug + name: Beclomethasone dipropionate + - alt_names: + - Beclomethasone 17-monopropionate + id: CHEBI:3001 + label: ChemicalSubstance + name: beclomethasone + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: GO:0042311 + label: BiologicalProcess + name: vasodilation + - id: MESH:D012223 + label: Disease + name: Vasomotor rhinitis + reference: + - https://go.drugbank.com/drugs/DB00394 + - https://en.wikipedia.org/wiki/Corticosteroid#Classes +- comment: Beclomethasone dipropionate is a prodrug, giving rise to Beclomethasone + (MESH:D001507), also known as Beclomethasone 17-monopropionate (https://pubchem.ncbi.nlm.nih.gov/compound/17-BMP). + directed: true + graph: + _id: DB00394_MESH_D009298_1 + disease: Nasal polyp + disease_mesh: MESH:D009298 + drug: Beclomethasone dipropionate + drug_mesh: null + drugbank: DB:DB00394 + links: + - key: has metabolite + source: DB:DB00394 + target: CHEBI:3001 + - key: positively regulates + source: CHEBI:3001 + target: UniProt:P04150 + - key: negatively regulates + source: UniProt:P04150 + target: GO:0006954 + - key: positively correlated with + source: GO:0006954 + target: MESH:D009298 + multigraph: true + nodes: + - id: DB:DB00394 + label: Drug + name: Beclomethasone dipropionate + - alt_names: + - Beclomethasone 17-monopropionate + id: CHEBI:3001 + label: ChemicalSubstance + name: beclomethasone + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: GO:0006954 + label: BiologicalProcess + name: inflammatory response + - id: MESH:D009298 + label: Disease + name: Nasal polyp + reference: + - https://go.drugbank.com/drugs/DB00394 + - https://en.wikipedia.org/wiki/Beclometasone#Pharmacology + - https://en.wikipedia.org/wiki/Nasal_polyp#Pathophysiology +- comment: Beclomethasone dipropionate is a prodrug, giving rise to Beclomethasone + (MESH:D001507), also known as Beclomethasone 17-monopropionate (https://pubchem.ncbi.nlm.nih.gov/compound/17-BMP). + directed: true + graph: + _id: DB00394_MESH_D001249_1 + disease: Asthma + disease_mesh: MESH:D001249 + drug: Beclomethasone dipropionate + drug_mesh: null + drugbank: DB:DB00394 + links: + - key: has metabolite + source: DB:DB00394 + target: CHEBI:3001 + - key: positively regulates + source: CHEBI:3001 + target: UniProt:P04150 + - key: negatively regulates + source: UniProt:P04150 + target: GO:0006954 + - key: positively correlated with + source: GO:0006954 + target: MESH:D001249 + multigraph: true + nodes: + - id: DB:DB00394 + label: Drug + name: Beclomethasone dipropionate + - alt_names: + - Beclomethasone 17-monopropionate + id: CHEBI:3001 + label: ChemicalSubstance + name: beclomethasone + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: GO:0006954 + label: BiologicalProcess + name: inflammatory response + - id: MESH:D001249 + label: Disease + name: Asthma + reference: + - https://go.drugbank.com/drugs/DB00394 + - https://en.wikipedia.org/wiki/Beclometasone#Pharmacology +- comment: Beclomethasone dipropionate is a prodrug, giving rise to Beclomethasone + (MESH:D001507), also known as Beclomethasone 17-monopropionate (https://pubchem.ncbi.nlm.nih.gov/compound/17-BMP). + directed: true + graph: + _id: DB00394_MESH_D065631_1 + disease: Allergic rhinitis + disease_mesh: MESH:D065631 + drug: Beclomethasone dipropionate + drug_mesh: null + drugbank: DB:DB00394 + links: + - key: has metabolite + source: DB:DB00394 + target: CHEBI:3001 + - key: positively regulates + source: CHEBI:3001 + target: UniProt:P04150 + - key: negatively regulates + source: UniProt:P04150 + target: GO:0006954 + - key: positively correlated with + source: GO:0006954 + target: MESH:D065631 + multigraph: true + nodes: + - id: DB:DB00394 + label: Drug + name: Beclomethasone dipropionate + - alt_names: + - Beclomethasone 17-monopropionate + id: CHEBI:3001 + label: ChemicalSubstance + name: beclomethasone + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: GO:0006954 + label: BiologicalProcess + name: inflammatory response + - id: MESH:D065631 + label: Disease + name: Allergic rhinitis + reference: + - https://go.drugbank.com/drugs/DB00394 + - https://en.wikipedia.org/wiki/Beclometasone#Pharmacology +- directed: true + graph: + _id: DB00426_MESH_D006562_1 + disease: Herpes zoster + disease_mesh: MESH:D006562 + drug: famciclovir + drug_mesh: MESH:D000077595 + drugbank: DB:DB00426 + links: + - key: has metabolite + source: MESH:D000077595 + target: DB:DB00299 + - key: negatively regulates + source: DB:DB00299 + target: UniProt:P09252 + - key: positively regulates + source: UniProt:P09252 + target: GO:0039693 + - key: in taxon + source: GO:0039693 + target: NCBITaxon:10335 + - key: causes + source: NCBITaxon:10335 + target: MESH:D006562 + multigraph: true + nodes: + - id: MESH:D000077595 + label: Drug + name: famciclovir + - id: DB:DB00299 + label: Drug + name: Penciclovir + - id: UniProt:P09252 + label: Protein + name: DNA polymerase catalytic subunit + - id: GO:0039693 + label: BiologicalProcess + name: viral DNA genome replication + - id: NCBITaxon:10335 + label: OrganismTaxon + name: Human alphaherpesvirus 3 + - id: MESH:D006562 + label: Disease + name: Herpes zoster + reference: + - https://go.drugbank.com/drugs/DB00426 +- directed: true + graph: + _id: DB06820_MESH_D014008_1 + disease: Tinea pedis + disease_mesh: MESH:D014008 + drug: sulconazole + drug_mesh: MESH:C033308 + drugbank: DB:DB06820 + links: + - key: negatively regulates + source: MESH:C033308 + target: UniProt:P10613 + - key: positively regulates + source: UniProt:P10613 + target: GO:0006696 + - key: in taxon + source: GO:0006696 + target: NCBITaxon:237561 + - key: causes + source: NCBITaxon:237561 + target: MESH:D014008 + multigraph: true + nodes: + - id: MESH:C033308 + label: Drug + name: sulconazole + - id: UniProt:P10613 + label: Protein + name: Lanosterol 14-alpha demethylase + - id: GO:0006696 + label: BiologicalProcess + name: ergosterol biosynthetic process + - id: NCBITaxon:237561 + label: OrganismTaxon + name: Candida albicans SC5314 + - id: MESH:D014008 + label: Disease + name: Tinea pedis + reference: + - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1221/ +- directed: true + graph: + _id: DB06820_MESH_D014010_1 + disease: Pityriasis versicolor + disease_mesh: MESH:D014010 + drug: sulconazole + drug_mesh: MESH:C033308 + drugbank: DB:DB06820 + links: + - key: negatively regulates + source: MESH:C033308 + target: UniProt:P10613 + - key: positively regulates + source: UniProt:P10613 + target: GO:0006696 + - key: in taxon + source: GO:0006696 + target: NCBITaxon:237561 + - key: causes + source: NCBITaxon:237561 + target: MESH:D014010 + multigraph: true + nodes: + - id: MESH:C033308 + label: Drug + name: sulconazole + - id: UniProt:P10613 + label: Protein + name: Lanosterol 14-alpha demethylase + - id: GO:0006696 + label: BiologicalProcess + name: ergosterol biosynthetic process + - id: NCBITaxon:237561 + label: OrganismTaxon + name: Candida albicans SC5314 + - id: MESH:D014010 + label: Disease + name: Pityriasis versicolor + reference: + - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1221/ +- directed: true + graph: + _id: DB00682_MESH_D013923_1 + disease: Thromboembolic disorder + disease_mesh: MESH:D013923 + drug: warfarin + drug_mesh: MESH:D014859 + drugbank: DB:DB00682 + links: + - key: negatively regulates + source: MESH:D014859 + target: UniProt:Q9BQB6 + - key: positively regulates + source: UniProt:Q9BQB6 + target: GO:0007596 + - key: correlated with + source: GO:0007596 + target: GO:0072378 + - key: affects risk for + source: GO:0072378 + target: MESH:D013923 + multigraph: true + nodes: + - id: MESH:D014859 + label: Drug + name: warfarin + - id: UniProt:Q9BQB6 + label: Protein + name: Vitamin K epoxide reductase complex subunit 1 + - id: GO:0007596 + label: BiologicalProcess + name: blood coagulation + - id: GO:0072378 + label: BiologicalProcess + name: blood coagulation, fibrin clot formation + - id: MESH:D013923 + label: Disease + name: Thromboembolic disorder + reference: + - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1464/ + - https://go.drugbank.com/drugs/DB00682 +- directed: true + graph: + _id: DB00682_MESH_D020766_1 + disease: Cerebral embolism + disease_mesh: MESH:D020766 + drug: warfarin + drug_mesh: MESH:D014859 + drugbank: DB:DB00682 + links: + - key: negatively regulates + source: MESH:D014859 + target: UniProt:Q9BQB6 + - key: positively regulates + source: UniProt:Q9BQB6 + target: GO:0007596 + - key: correlated with + source: GO:0007596 + target: GO:0072378 + - key: affects risk for + source: GO:0072378 + target: MESH:D020766 + multigraph: true + nodes: + - id: MESH:D014859 + label: Drug + name: warfarin + - id: UniProt:Q9BQB6 + label: Protein + name: Vitamin K epoxide reductase complex subunit 1 + - id: GO:0007596 + label: BiologicalProcess + name: blood coagulation + - id: GO:0072378 + label: BiologicalProcess + name: blood coagulation, fibrin clot formation + - id: MESH:D020766 + label: Disease + name: Cerebral embolism + reference: + - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1464/ + - https://go.drugbank.com/drugs/DB00682 +- directed: true + graph: + _id: DB00682_MESH_D020246_1 + disease: Deep venous thrombosis + disease_mesh: MESH:D020246 + drug: warfarin + drug_mesh: MESH:D014859 + drugbank: DB:DB00682 + links: + - key: negatively regulates + source: MESH:D014859 + target: UniProt:Q9BQB6 + - key: positively regulates + source: UniProt:Q9BQB6 + target: GO:0007596 + - key: correlated with + source: GO:0007596 + target: GO:0072378 + - key: affects risk for + source: GO:0072378 + target: MESH:D020246 + multigraph: true + nodes: + - id: MESH:D014859 + label: Drug + name: warfarin + - id: UniProt:Q9BQB6 + label: Protein + name: Vitamin K epoxide reductase complex subunit 1 + - id: GO:0007596 + label: BiologicalProcess + name: blood coagulation + - id: GO:0072378 + label: BiologicalProcess + name: blood coagulation, fibrin clot formation + - id: MESH:D020246 + label: Disease + name: Deep venous thrombosis + reference: + - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1464/ + - https://go.drugbank.com/drugs/DB00682 +- directed: true + graph: + _id: DB00682_MESH_D013927_1 + disease: Thrombosis + disease_mesh: MESH:D013927 + drug: warfarin + drug_mesh: MESH:D014859 + drugbank: DB:DB00682 + links: + - key: negatively regulates + source: MESH:D014859 + target: UniProt:Q9BQB6 + - key: positively regulates + source: UniProt:Q9BQB6 + target: GO:0007596 + - key: correlated with + source: GO:0007596 + target: GO:0072378 + - key: affects risk for + source: GO:0072378 + target: MESH:D013927 + multigraph: true + nodes: + - id: MESH:D014859 + label: Drug + name: warfarin + - id: UniProt:Q9BQB6 + label: Protein + name: Vitamin K epoxide reductase complex subunit 1 + - id: GO:0007596 + label: BiologicalProcess + name: blood coagulation + - id: GO:0072378 + label: BiologicalProcess + name: blood coagulation, fibrin clot formation + - id: MESH:D013927 + label: Disease + name: Thrombosis + reference: + - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1464/ + - https://go.drugbank.com/drugs/DB00682 +- directed: true + graph: + _id: DB00682_MESH_D011655_2 + disease: Pulmonary thromboembolism + disease_mesh: MESH:D011655 + drug: warfarin + drug_mesh: MESH:D014859 + drugbank: DB:DB00682 + links: + - key: negatively regulates + source: MESH:D014859 + target: UniProt:Q9BQB6 + - key: positively regulates + source: UniProt:Q9BQB6 + target: GO:0007596 + - key: correlated with + source: GO:0007596 + target: GO:0072378 + - key: affects risk for + source: GO:0072378 + target: MESH:D011655 + multigraph: true + nodes: + - id: MESH:D014859 + label: Drug + name: warfarin + - id: UniProt:Q9BQB6 + label: Protein + name: Vitamin K epoxide reductase complex subunit 1 + - id: GO:0007596 + label: BiologicalProcess + name: blood coagulation + - id: GO:0072378 + label: BiologicalProcess + name: blood coagulation, fibrin clot formation + - id: MESH:D011655 + label: Disease + name: Pulmonary thromboembolism + reference: + - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1464/ + - https://go.drugbank.com/drugs/DB00682 +- directed: true + graph: + _id: DB00013_MESH_D011655_1 + disease: Pulmonary thromboembolism + disease_mesh: MESH:D011655 + drug: urokinase + drug_mesh: MESH:D014568 + drugbank: DB:DB00013 + links: + - key: positively regulates + source: MESH:D014568 + target: UniProt:P00747 + - key: positively regulates + source: UniProt:P00747 + target: GO:0042730 + - key: negatively correlated with + source: GO:0042730 + target: MESH:D011655 + multigraph: true + nodes: + - id: MESH:D014568 + label: Drug + name: urokinase + - id: UniProt:P00747 + label: Protein + name: Plasminogen + - id: GO:0042730 + label: BiologicalProcess + name: fibrinolysis + - id: MESH:D011655 + label: Disease + name: Pulmonary thromboembolism + reference: + - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201420/ + - https://go.drugbank.com/drugs/DB00013 +- directed: true + graph: + _id: DB08162_MESH_D020301_1 + disease: Spasm of cerebral arteries + disease_mesh: MESH:D020301 + drug: fasudil + drug_mesh: MESH:C049347 + drugbank: DB:DB08162 + links: + - key: has metabolite + source: MESH:C049347 + target: DB:DB04707 + - key: decreases activity of + source: DB:DB04707 + target: UniProt:Q13464 + - key: positively regulates + source: UniProt:Q13464 + target: GO:0014829 + - key: positively correlated with + source: GO:0014829 + target: MESH:D020301 + multigraph: true + nodes: + - id: MESH:C049347 + label: Drug + name: fasudil + - id: DB:DB04707 + label: ChemicalSubstance + name: Hydroxyfasudil + - id: UniProt:Q13464 + label: Protein + name: Rho-associated protein kinase 1 + - id: GO:0014829 + label: BiologicalProcess + name: vascular associated smooth muscle contraction + - id: MESH:D020301 + label: Disease + name: Spasm of cerebral arteries + reference: + - https://en.wikipedia.org/wiki/Fasudil + - https://en.wikipedia.org/wiki/Rho_kinase_inhibitor + - https://go.drugbank.com/drugs/DB04707#BE0001016 +- comment: Tipiracil may also play its anti-neoplastic role indirectly when admnistered + in combination with Trifluridine (DB:DB00432). In this case, tipiracil will + prevent trifluridine breakdown, thus increasing its bioavailability and boosting + its systemiic presence (https://en.wikipedia.org/wiki/Trifluridine/tipiracil). + directed: true + graph: + _id: DB09343_MESH_D003110_1 + disease: Malignant tumor of colon + disease_mesh: MESH:D003110 + drug: tipiracil + drug_mesh: MESH:C000613754 + drugbank: DB:DB09343 + links: + - key: decreases activity of + source: MESH:C000613754 + target: UniProt:P19971 + - key: positively regulates + source: UniProt:P19971 + target: GO:0001525 + - key: positively correlated with + source: GO:0001525 + target: MESH:D003110 + multigraph: true + nodes: + - id: MESH:C000613754 + label: Drug + name: tipiracil + - id: UniProt:P19971 + label: Protein + name: Thymidine phosphorylase + - id: GO:0001525 + label: BiologicalProcess + name: angiogenesis + - id: MESH:D003110 + label: Disease + name: Malignant tumor of colon + reference: + - https://go.drugbank.com/drugs/DB09343 +- directed: true + graph: + _id: DB09517_MESH_D018798_1 + disease: Iron deficiency anemia + disease_mesh: MESH:D018798 + drug: ferrous gluconate + drug_mesh: MESH:C011819 + drugbank: DB:DB09517 + links: + - key: increases abundance of + source: MESH:C011819 + target: CHEBI:18248 + - key: correlated with + source: CHEBI:18248 + target: GO:0055072 + - key: negatively correlated with + source: GO:0055072 + target: MESH:D018798 + multigraph: true + nodes: + - id: MESH:C011819 + label: Drug + name: ferrous gluconate + - id: CHEBI:18248 + label: ChemicalSubstance + name: iron atom + - id: GO:0055072 + label: BiologicalProcess + name: iron ion homeostasis + - id: MESH:D018798 + label: Disease + name: Iron deficiency anemia + reference: + - https://en.wikipedia.org/wiki/Iron(II)_gluconate +- comment: The drug has no anti-parkinson activity per se. It is admnistered in + combination with levodopa to prevent levodopa degradation to dopamine in extracerebral + tissue, thereby decreasing the peripheral side effects of levodopa. + directed: true + graph: + _id: DB00190_MESH_D010300_1 + disease: Parkinson's disease + disease_mesh: MESH:D010300 + drug: carbidopa + drug_mesh: MESH:D002230 + drugbank: DB:DB00190 + links: + - key: negatively regulates + source: MESH:D002230 + target: UniProt:P20711 + - key: positively regulates + source: UniProt:P20711 + target: GO:1903184 + - key: positively correlated with + source: GO:1903184 + target: HP:0002017 + - key: manifestation of + source: HP:0002017 + target: MESH:D010300 + multigraph: true + nodes: + - id: MESH:D002230 + label: Drug + name: carbidopa + - id: UniProt:P20711 + label: Protein + name: Aromatic-L-amino-acid decarboxylase + - id: GO:1903184 + label: BiologicalProcess + name: L-dopa metabolic process + - id: HP:0002017 + label: PhenotypicFeature + name: Nausea and vomiting + - id: MESH:D010300 + label: Disease + name: Parkinson's disease + reference: + - https://go.drugbank.com/drugs/DB00190 + - https://www.ebmconsult.com/articles/carbidopa-levodopa-parkinson-disease + - https://en.wikipedia.org/wiki/L-DOPA#Medical_use + - https://en.wikipedia.org/wiki/Aromatic_L-amino_acid_decarboxylase_inhibitor + - https://en.wikipedia.org/wiki/Carbidopa/levodopa#Mechanism_of_action +- comment: The drug has no anti-parkinson activity per se. It is admnistered in + combination with levodopa to prevent levodopa degradation to dopamine in extracerebral + tissue, thereby decreasing the peripheral side effects of levodopa. + directed: true + graph: + _id: DB00190_MESH_D020734_1 + disease: Parkinsonism + disease_mesh: MESH:D020734 + drug: carbidopa + drug_mesh: MESH:D002230 + drugbank: DB:DB00190 + links: + - key: negatively regulates + source: MESH:D002230 + target: UniProt:P20711 + - key: positively regulates + source: UniProt:P20711 + target: GO:1903184 + - key: correlated with + source: GO:1903184 + target: HP:0002017 + - key: manifestation of + source: HP:0002017 + target: MESH:D020734 + multigraph: true + nodes: + - id: MESH:D002230 + label: Drug + name: carbidopa + - id: UniProt:P20711 + label: Protein + name: Aromatic-L-amino-acid decarboxylase + - id: GO:1903184 + label: BiologicalProcess + name: L-dopa metabolic process + - id: HP:0002017 + label: PhenotypicFeature + name: Nausea and vomiting + - id: MESH:D020734 + label: Disease + name: Parkinsonism + reference: + - https://go.drugbank.com/drugs/DB00190 + - https://www.ebmconsult.com/articles/carbidopa-levodopa-parkinson-disease + - https://en.wikipedia.org/wiki/L-DOPA#Medical_use + - https://en.wikipedia.org/wiki/Aromatic_L-amino_acid_decarboxylase_inhibitor + - https://en.wikipedia.org/wiki/Carbidopa/levodopa#Mechanism_of_action +- comment: The drug has no anti-parkinson activity per se. It is admnistered in + combination with levodopa to prevent levodopa degradation to dopamine in extracerebral + tissue, thereby decreasing the peripheral side effects of levodopa. + directed: true + graph: + _id: DB00190_MESH_D010301_1 + disease: Postencephalitic parkinsonism + disease_mesh: MESH:D010301 + drug: carbidopa + drug_mesh: MESH:D002230 + drugbank: DB:DB00190 + links: + - key: negatively regulates + source: MESH:D002230 + target: UniProt:P20711 + - key: positively regulates + source: UniProt:P20711 + target: GO:1903184 + - key: correlated with + source: GO:1903184 + target: HP:0002017 + - key: manifestation of + source: HP:0002017 + target: MESH:D010301 + multigraph: true + nodes: + - id: MESH:D002230 + label: Drug + name: carbidopa + - id: UniProt:P20711 + label: Protein + name: Aromatic-L-amino-acid decarboxylase + - id: GO:1903184 + label: BiologicalProcess + name: L-dopa metabolic process + - id: HP:0002017 + label: PhenotypicFeature + name: Nausea and vomiting + - id: MESH:D010301 + label: Disease + name: Postencephalitic parkinsonism + reference: + - https://go.drugbank.com/drugs/DB00190 + - https://www.ebmconsult.com/articles/carbidopa-levodopa-parkinson-disease + - https://en.wikipedia.org/wiki/L-DOPA#Medical_use + - https://en.wikipedia.org/wiki/Aromatic_L-amino_acid_decarboxylase_inhibitor + - https://en.wikipedia.org/wiki/Carbidopa/levodopa#Mechanism_of_action diff --git a/submission.yaml b/submission.yaml index 4fd4064aa..8b1378917 100644 --- a/submission.yaml +++ b/submission.yaml @@ -1,808 +1 @@ -- directed: true - graph: - disease: Rhinitis - disease_mesh: MESH:D012220 - drug: Beclomethasone dipropionate - drug_mesh: null - drugbank: DB:DB00394 - links: - - key: has metabolite - source: DB:DB00394 - target: CHEBI:3001 - - key: positively regulates - source: CHEBI:3001 - target: UniProt:P04150 - - key: negatively regulates - source: UniProt:P04150 - target: GO:0006954 - - key: positively correlated with - source: GO:0006954 - target: MESH:D012220 - multigraph: true - nodes: - - id: DB:DB00394 - label: Drug - name: Beclomethasone dipropionate - - id: CHEBI:3001 - label: ChemicalSubstance - name: beclomethasone - alt_names: - - Beclomethasone 17-monopropionate - - id: UniProt:P04150 - label: Protein - name: Glucocorticoid receptor - - id: GO:0006954 - label: BiologicalProcess - name: inflammatory response - - id: MESH:D012220 - label: Disease - name: Rhinitis - reference: - - https://go.drugbank.com/drugs/DB00394 - - https://en.wikipedia.org/wiki/Beclometasone#Pharmacology - comment: Beclomethasone dipropionate is a prodrug, which gives rise to Beclomethasone (MESH:D001507), also known as Beclomethasone 17-monopropionate (https://pubchem.ncbi.nlm.nih.gov/compound/17-BMP). -- directed: true - graph: - disease: Vasomotor rhinitis - disease_mesh: MESH:D012223 - drug: Beclomethasone dipropionate - drug_mesh: null - drugbank: DB:DB00394 - links: - - key: has metabolite - source: DB:DB00394 - target: CHEBI:3001 - - key: positively regulates - source: CHEBI:3001 - target: UniProt:P04150 - - key: negatively regulates - source: UniProt:P04150 - target: GO:0042311 - - key: positively correlated with - source: GO:0042311 - target: MESH:D012223 - multigraph: true - nodes: - - id: DB:DB00394 - label: Drug - name: Beclomethasone dipropionate - - id: CHEBI:3001 - label: ChemicalSubstance - name: beclomethasone - alt_names: - - Beclomethasone 17-monopropionate - - id: UniProt:P04150 - label: Protein - name: Glucocorticoid receptor - - id: GO:0042311 - label: BiologicalProcess - name: vasodilation - - id: MESH:D012223 - label: Disease - name: Vasomotor rhinitis - reference: - - https://go.drugbank.com/drugs/DB00394 - - https://en.wikipedia.org/wiki/Corticosteroid#Classes - comment: Beclomethasone dipropionate is a prodrug, giving rise to Beclomethasone (MESH:D001507), also known as Beclomethasone 17-monopropionate (https://pubchem.ncbi.nlm.nih.gov/compound/17-BMP). -- directed: true - graph: - disease: Nasal polyp - disease_mesh: MESH:D009298 - drug: Beclomethasone dipropionate - drug_mesh: null - drugbank: DB:DB00394 - links: - - key: has metabolite - source: DB:DB00394 - target: CHEBI:3001 - - key: positively regulates - source: CHEBI:3001 - target: UniProt:P04150 - - key: negatively regulates - source: UniProt:P04150 - target: GO:0006954 - - key: positively correlated with - source: GO:0006954 - target: MESH:D009298 - multigraph: true - nodes: - - id: DB:DB00394 - label: Drug - name: Beclomethasone dipropionate - - id: CHEBI:3001 - label: ChemicalSubstance - name: beclomethasone - alt_names: - - Beclomethasone 17-monopropionate - - id: UniProt:P04150 - label: Protein - name: Glucocorticoid receptor - - id: GO:0006954 - label: BiologicalProcess - name: inflammatory response - - id: MESH:D009298 - label: Disease - name: Nasal polyp - reference: - - https://go.drugbank.com/drugs/DB00394 - - https://en.wikipedia.org/wiki/Beclometasone#Pharmacology - - https://en.wikipedia.org/wiki/Nasal_polyp#Pathophysiology - comment: Beclomethasone dipropionate is a prodrug, giving rise to Beclomethasone (MESH:D001507), also known as Beclomethasone 17-monopropionate (https://pubchem.ncbi.nlm.nih.gov/compound/17-BMP). -- directed: true - graph: - disease: Asthma - disease_mesh: MESH:D001249 - drug: Beclomethasone dipropionate - drug_mesh: null - drugbank: DB:DB00394 - links: - - key: has metabolite - source: DB:DB00394 - target: CHEBI:3001 - - key: positively regulates - source: CHEBI:3001 - target: UniProt:P04150 - - key: negatively regulates - source: UniProt:P04150 - target: GO:0006954 - - key: positively correlated with - source: GO:0006954 - target: MESH:D001249 - multigraph: true - nodes: - - id: DB:DB00394 - label: Drug - name: Beclomethasone dipropionate - - id: CHEBI:3001 - label: ChemicalSubstance - name: beclomethasone - alt_names: - - Beclomethasone 17-monopropionate - - id: UniProt:P04150 - label: Protein - name: Glucocorticoid receptor - - id: GO:0006954 - label: BiologicalProcess - name: inflammatory response - - id: MESH:D001249 - label: Disease - name: Asthma - reference: - - https://go.drugbank.com/drugs/DB00394 - - https://en.wikipedia.org/wiki/Beclometasone#Pharmacology - comment: Beclomethasone dipropionate is a prodrug, giving rise to Beclomethasone (MESH:D001507), also known as Beclomethasone 17-monopropionate (https://pubchem.ncbi.nlm.nih.gov/compound/17-BMP). -- directed: true - graph: - disease: Allergic rhinitis - disease_mesh: MESH:D065631 - drug: Beclomethasone dipropionate - drug_mesh: null - drugbank: DB:DB00394 - links: - - key: has metabolite - source: DB:DB00394 - target: CHEBI:3001 - - key: positively regulates - source: CHEBI:3001 - target: UniProt:P04150 - - key: negatively regulates - source: UniProt:P04150 - target: GO:0006954 - - key: positively correlated with - source: GO:0006954 - target: MESH:D065631 - multigraph: true - nodes: - - id: DB:DB00394 - label: Drug - name: Beclomethasone dipropionate - - id: CHEBI:3001 - label: ChemicalSubstance - name: beclomethasone - alt_names: - - Beclomethasone 17-monopropionate - - id: UniProt:P04150 - label: Protein - name: Glucocorticoid receptor - - id: GO:0006954 - label: BiologicalProcess - name: inflammatory response - - id: MESH:D065631 - label: Disease - name: Allergic rhinitis - reference: - - https://go.drugbank.com/drugs/DB00394 - - https://en.wikipedia.org/wiki/Beclometasone#Pharmacology - comment: Beclomethasone dipropionate is a prodrug, giving rise to Beclomethasone (MESH:D001507), also known as Beclomethasone 17-monopropionate (https://pubchem.ncbi.nlm.nih.gov/compound/17-BMP). -- directed: true - graph: - disease: Herpes zoster - disease_mesh: MESH:D006562 - drug: famciclovir - drug_mesh: MESH:D000077595 - drugbank: DB:DB00426 - links: - - key: has metabolite - source: MESH:D000077595 - target: DB:DB00299 - - key: negatively regulates - source: DB:DB00299 - target: UniProt:P09252 - - key: positively regulates - source: UniProt:P09252 - target: GO:0039693 - - key: in taxon - source: GO:0039693 - target: NCBITaxon:10335 - - key: causes - source: NCBITaxon:10335 - target: MESH:D006562 - multigraph: true - nodes: - - id: MESH:D000077595 - label: Drug - name: famciclovir - - id: DB:DB00299 - label: Drug - name: Penciclovir - - id: UniProt:P09252 - label: Protein - name: DNA polymerase catalytic subunit - - id: GO:0039693 - label: BiologicalProcess - name: viral DNA genome replication - - id: NCBITaxon:10335 - label: OrganismTaxon - name: Human alphaherpesvirus 3 - - id: MESH:D006562 - label: Disease - name: Herpes zoster - reference: https://go.drugbank.com/drugs/DB00426 -- directed: true - graph: - disease: Tinea pedis - disease_mesh: MESH:D014008 - drug: sulconazole - drug_mesh: MESH:C033308 - drugbank: DB:DB06820 - links: - - key: negatively regulates - source: MESH:C033308 - target: UniProt:P10613 - - key: positively regulates - source: UniProt:P10613 - target: GO:0006696 - - key: in taxon - source: GO:0006696 - target: NCBITaxon:237561 - - key: causes - source: NCBITaxon:237561 - target: MESH:D014008 - multigraph: true - nodes: - - id: MESH:C033308 - label: Drug - name: sulconazole - - id: UniProt:P10613 - label: Protein - name: Lanosterol 14-alpha demethylase - - id: GO:0006696 - label: BiologicalProcess - name: ergosterol biosynthetic process - - id: NCBITaxon:237561 - label: OrganismTaxon - name: Candida albicans SC5314 - - id: MESH:D014008 - label: Disease - name: Tinea pedis - reference: https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1221/ -- directed: true - graph: - disease: Pityriasis versicolor - disease_mesh: MESH:D014010 - drug: sulconazole - drug_mesh: MESH:C033308 - drugbank: DB:DB06820 - links: - - key: negatively regulates - source: MESH:C033308 - target: UniProt:P10613 - - key: positively regulates - source: UniProt:P10613 - target: GO:0006696 - - key: in taxon - source: GO:0006696 - target: NCBITaxon:237561 - - key: causes - source: NCBITaxon:237561 - target: MESH:D014010 - multigraph: true - nodes: - - id: MESH:C033308 - label: Drug - name: sulconazole - - id: UniProt:P10613 - label: Protein - name: Lanosterol 14-alpha demethylase - - id: GO:0006696 - label: BiologicalProcess - name: ergosterol biosynthetic process - - id: NCBITaxon:237561 - label: OrganismTaxon - name: Candida albicans SC5314 - - id: MESH:D014010 - label: Disease - name: Pityriasis versicolor - reference: https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1221/ -- directed: true - graph: - disease: Thromboembolic disorder - disease_mesh: MESH:D013923 - drug: warfarin - drug_mesh: MESH:D014859 - drugbank: DB:DB00682 - links: - - key: negatively regulates - source: MESH:D014859 - target: UniProt:Q9BQB6 - - key: positively regulates - source: UniProt:Q9BQB6 - target: GO:0007596 - - key: correlated with - source: GO:0007596 - target: GO:0072378 - - key: affects risk for - source: GO:0072378 - target: MESH:D013923 - multigraph: true - nodes: - - id: MESH:D014859 - label: Drug - name: warfarin - - id: UniProt:Q9BQB6 - label: Protein - name: Vitamin K epoxide reductase complex subunit 1 - - id: GO:0007596 - label: BiologicalProcess - name: blood coagulation - - id: GO:0072378 - label: BiologicalProcess - name: blood coagulation, fibrin clot formation - - id: MESH:D013923 - label: Disease - name: Thromboembolic disorder - reference: - - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1464/ - - https://go.drugbank.com/drugs/DB00682 -- directed: true - graph: - disease: Cerebral embolism - disease_mesh: MESH:D020766 - drug: warfarin - drug_mesh: MESH:D014859 - drugbank: DB:DB00682 - links: - - key: negatively regulates - source: MESH:D014859 - target: UniProt:Q9BQB6 - - key: positively regulates - source: UniProt:Q9BQB6 - target: GO:0007596 - - key: correlated with - source: GO:0007596 - target: GO:0072378 - - key: affects risk for - source: GO:0072378 - target: MESH:D020766 - multigraph: true - nodes: - - id: MESH:D014859 - label: Drug - name: warfarin - - id: UniProt:Q9BQB6 - label: Protein - name: Vitamin K epoxide reductase complex subunit 1 - - id: GO:0007596 - label: BiologicalProcess - name: blood coagulation - - id: GO:0072378 - label: BiologicalProcess - name: blood coagulation, fibrin clot formation - - id: MESH:D020766 - label: Disease - name: Cerebral embolism - reference: - - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1464/ - - https://go.drugbank.com/drugs/DB00682 -- directed: true - graph: - disease: Deep venous thrombosis - disease_mesh: MESH:D020246 - drug: warfarin - drug_mesh: MESH:D014859 - drugbank: DB:DB00682 - links: - - key: negatively regulates - source: MESH:D014859 - target: UniProt:Q9BQB6 - - key: positively regulates - source: UniProt:Q9BQB6 - target: GO:0007596 - - key: correlated with - source: GO:0007596 - target: GO:0072378 - - key: affects risk for - source: GO:0072378 - target: MESH:D020246 - multigraph: true - nodes: - - id: MESH:D014859 - label: Drug - name: warfarin - - id: UniProt:Q9BQB6 - label: Protein - name: Vitamin K epoxide reductase complex subunit 1 - - id: GO:0007596 - label: BiologicalProcess - name: blood coagulation - - id: GO:0072378 - label: BiologicalProcess - name: blood coagulation, fibrin clot formation - - id: MESH:D020246 - label: Disease - name: Deep venous thrombosis - reference: - - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1464/ - - https://go.drugbank.com/drugs/DB00682 -- directed: true - graph: - disease: Thrombosis - disease_mesh: MESH:D013927 - drug: warfarin - drug_mesh: MESH:D014859 - drugbank: DB:DB00682 - links: - - key: negatively regulates - source: MESH:D014859 - target: UniProt:Q9BQB6 - - key: positively regulates - source: UniProt:Q9BQB6 - target: GO:0007596 - - key: correlated with - source: GO:0007596 - target: GO:0072378 - - key: affects risk for - source: GO:0072378 - target: MESH:D013927 - multigraph: true - nodes: - - id: MESH:D014859 - label: Drug - name: warfarin - - id: UniProt:Q9BQB6 - label: Protein - name: Vitamin K epoxide reductase complex subunit 1 - - id: GO:0007596 - label: BiologicalProcess - name: blood coagulation - - id: GO:0072378 - label: BiologicalProcess - name: blood coagulation, fibrin clot formation - - id: MESH:D013927 - label: Disease - name: Thrombosis - reference: - - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1464/ - - https://go.drugbank.com/drugs/DB00682 -- directed: true - graph: - disease: Pulmonary thromboembolism - disease_mesh: MESH:D011655 - drug: warfarin - drug_mesh: MESH:D014859 - drugbank: DB:DB00682 - links: - - key: negatively regulates - source: MESH:D014859 - target: UniProt:Q9BQB6 - - key: positively regulates - source: UniProt:Q9BQB6 - target: GO:0007596 - - key: correlated with - source: GO:0007596 - target: GO:0072378 - - key: affects risk for - source: GO:0072378 - target: MESH:D011655 - multigraph: true - nodes: - - id: MESH:D014859 - label: Drug - name: warfarin - - id: UniProt:Q9BQB6 - label: Protein - name: Vitamin K epoxide reductase complex subunit 1 - - id: GO:0007596 - label: BiologicalProcess - name: blood coagulation - - id: GO:0072378 - label: BiologicalProcess - name: blood coagulation, fibrin clot formation - - id: MESH:D011655 - label: Disease - name: Pulmonary thromboembolism - reference: - - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1464/ - - https://go.drugbank.com/drugs/DB00682 -- directed: true - graph: - disease: Pulmonary thromboembolism - disease_mesh: MESH:D011655 - drug: urokinase - drug_mesh: MESH:D014568 - drugbank: DB:DB00013 - links: - - key: positively regulates - source: MESH:D014568 - target: UniProt:P00747 - - key: positively regulates - source: UniProt:P00747 - target: GO:0042730 - - key: negatively correlated with - source: GO:0042730 - target: MESH:D011655 - multigraph: true - nodes: - - id: MESH:D014568 - label: Drug - name: urokinase - - id: UniProt:P00747 - label: Protein - name: Plasminogen - - id: GO:0042730 - label: BiologicalProcess - name: fibrinolysis - - id: MESH:D011655 - label: Disease - name: Pulmonary thromboembolism - reference: - - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201420/ - - https://go.drugbank.com/drugs/DB00013 -- directed: true - graph: - disease: Spasm of cerebral arteries - disease_mesh: MESH:D020301 - drug: fasudil - drug_mesh: MESH:C049347 - drugbank: DB:DB08162 - links: - - key: has metabolite - source: MESH:C049347 - target: DB:DB04707 - - key: decreases activity of - source: DB:DB04707 - target: UniProt:Q13464 - - key: positively regulates - source: UniProt:Q13464 - target: GO:0014829 - - key: positively correlated with - source: GO:0014829 - target: MESH:D020301 - multigraph: true - nodes: - - id: MESH:C049347 - label: Drug - name: fasudil - - id: DB:DB04707 - label: ChemicalSubstance - name: Hydroxyfasudil - - id: UniProt:Q13464 - label: Protein - name: Rho-associated protein kinase 1 - - id: GO:0014829 - label: BiologicalProcess - name: vascular associated smooth muscle contraction - - id: MESH:D020301 - label: Disease - name: Spasm of cerebral arteries - reference: - - https://en.wikipedia.org/wiki/Fasudil - - https://en.wikipedia.org/wiki/Rho_kinase_inhibitor - - https://go.drugbank.com/drugs/DB04707#BE0001016 -- directed: true - graph: - disease: Malignant tumor of colon - disease_mesh: MESH:D003110 - drug: tipiracil - drug_mesh: MESH:C000613754 - drugbank: DB:DB09343 - links: - - key: decreases activity of - source: MESH:C000613754 - target: UniProt:P19971 - - key: positively regulates - source: UniProt:P19971 - target: GO:0001525 - - key: positively correlated with - source: GO:0001525 - target: MESH:D003110 - multigraph: true - nodes: - - id: MESH:C000613754 - label: Drug - name: tipiracil - - id: UniProt:P19971 - label: Protein - name: Thymidine phosphorylase - - id: GO:0001525 - label: BiologicalProcess - name: angiogenesis - - id: MESH:D003110 - label: Disease - name: Malignant tumor of colon - reference: https://go.drugbank.com/drugs/DB09343 - comment: Tipiracil may also play its anti-neoplastic role indirectly when admnistered in combination with Trifluridine (DB:DB00432). In this case, tipiracil will prevent trifluridine breakdown, thus increasing its bioavailability and boosting its systemiic presence (https://en.wikipedia.org/wiki/Trifluridine/tipiracil). -- directed: true - graph: - disease: Iron deficiency anemia - disease_mesh: MESH:D018798 - drug: ferrous gluconate - drug_mesh: MESH:C011819 - drugbank: DB:DB09517 - links: - - key: increases abundance of - source: MESH:C011819 - target: CHEBI:18248 - - key: correlated with - source: CHEBI:18248 - target: GO:0055072 - - key: negatively correlated with - source: GO:0055072 - target: MESH:D018798 - multigraph: true - nodes: - - id: MESH:C011819 - label: Drug - name: ferrous gluconate - - id: CHEBI:18248 - label: ChemicalSubstance - name: iron atom - - id: GO:0055072 - label: BiologicalProcess - name: iron ion homeostasis - - id: MESH:D018798 - label: Disease - name: Iron deficiency anemia - reference: https://en.wikipedia.org/wiki/Iron(II)_gluconate -- directed: true - graph: - disease: Parkinson's disease - disease_mesh: MESH:D010300 - drug: carbidopa - drug_mesh: MESH:D002230 - drugbank: DB:DB00190 - links: - - key: negatively regulates - source: MESH:D002230 - target: UniProt:P20711 - - key: positively regulates - source: UniProt:P20711 - target: GO:1903184 - - key: positively correlated with - source: GO:1903184 - target: HP:0002017 - - key: manifestation of - source: HP:0002017 - target: MESH:D010300 - multigraph: true - nodes: - - id: MESH:D002230 - label: Drug - name: carbidopa - - id: UniProt:P20711 - label: Protein - name: Aromatic-L-amino-acid decarboxylase - - id: GO:1903184 - label: BiologicalProcess - name: L-dopa metabolic process - - id: HP:0002017 - label: PhenotypicFeature - name: Nausea and vomiting - - id: MESH:D010300 - label: Disease - name: Parkinson's disease - reference: - - https://go.drugbank.com/drugs/DB00190 - - https://www.ebmconsult.com/articles/carbidopa-levodopa-parkinson-disease - - https://en.wikipedia.org/wiki/L-DOPA#Medical_use - - https://en.wikipedia.org/wiki/Aromatic_L-amino_acid_decarboxylase_inhibitor - - https://en.wikipedia.org/wiki/Carbidopa/levodopa#Mechanism_of_action - comment: The drug has no anti-parkinson activity per se. It is admnistered in combination with levodopa to prevent levodopa degradation to dopamine in extracerebral tissue, thereby decreasing the peripheral side effects of levodopa. -- directed: true - graph: - disease: Parkinsonism - disease_mesh: MESH:D020734 - drug: carbidopa - drug_mesh: MESH:D002230 - drugbank: DB:DB00190 - links: - - key: negatively regulates - source: MESH:D002230 - target: UniProt:P20711 - - key: positively regulates - source: UniProt:P20711 - target: GO:1903184 - - key: correlated with - source: GO:1903184 - target: HP:0002017 - - key: manifestation of - source: HP:0002017 - target: MESH:D020734 - multigraph: true - nodes: - - id: MESH:D002230 - label: Drug - name: carbidopa - - id: UniProt:P20711 - label: Protein - name: Aromatic-L-amino-acid decarboxylase - - id: GO:1903184 - label: BiologicalProcess - name: L-dopa metabolic process - - id: HP:0002017 - label: PhenotypicFeature - name: Nausea and vomiting - - id: MESH:D020734 - label: Disease - name: Parkinsonism - reference: - - https://go.drugbank.com/drugs/DB00190 - - https://www.ebmconsult.com/articles/carbidopa-levodopa-parkinson-disease - - https://en.wikipedia.org/wiki/L-DOPA#Medical_use - - https://en.wikipedia.org/wiki/Aromatic_L-amino_acid_decarboxylase_inhibitor - - https://en.wikipedia.org/wiki/Carbidopa/levodopa#Mechanism_of_action - comment: The drug has no anti-parkinson activity per se. It is admnistered in combination with levodopa to prevent levodopa degradation to dopamine in extracerebral tissue, thereby decreasing the peripheral side effects of levodopa. -- directed: true - graph: - disease: Postencephalitic parkinsonism - disease_mesh: MESH:D010301 - drug: carbidopa - drug_mesh: MESH:D002230 - drugbank: DB:DB00190 - links: - - key: negatively regulates - source: MESH:D002230 - target: UniProt:P20711 - - key: positively regulates - source: UniProt:P20711 - target: GO:1903184 - - key: correlated with - source: GO:1903184 - target: HP:0002017 - - key: manifestation of - source: HP:0002017 - target: MESH:D010301 - multigraph: true - nodes: - - id: MESH:D002230 - label: Drug - name: carbidopa - - id: UniProt:P20711 - label: Protein - name: Aromatic-L-amino-acid decarboxylase - - id: GO:1903184 - label: BiologicalProcess - name: L-dopa metabolic process - - id: HP:0002017 - label: PhenotypicFeature - name: Nausea and vomiting - - id: MESH:D010301 - label: Disease - name: Postencephalitic parkinsonism - reference: - - https://go.drugbank.com/drugs/DB00190 - - https://www.ebmconsult.com/articles/carbidopa-levodopa-parkinson-disease - - https://en.wikipedia.org/wiki/L-DOPA#Medical_use - - https://en.wikipedia.org/wiki/Aromatic_L-amino_acid_decarboxylase_inhibitor - - https://en.wikipedia.org/wiki/Carbidopa/levodopa#Mechanism_of_action - comment: The drug has no anti-parkinson activity per se. It is admnistered in combination with levodopa to prevent levodopa degradation to dopamine in extracerebral tissue, thereby decreasing the peripheral side effects of levodopa. +