diff --git a/submission.yaml b/submission.yaml
index 633df10a3..e238c4357 100644
--- a/submission.yaml
+++ b/submission.yaml
@@ -20,7 +20,7 @@
         target: MESH:D006969
     -   key: contributes to
         source: MESH:D006969
-        target: MESH:D003233    
+        target: MESH:D003233
     multigraph: true
     nodes:
     -   id: MESH:C004649
@@ -40,8 +40,8 @@
         name: Hypersensitivity, Immediate
     -   id: MESH:D003233
         label: Disease
-        name: Conjunctivitis, Allergic    
-    reference: 
+        name: Conjunctivitis, Allergic
+    reference:
     -   https://go.drugbank.com/drugs/DB00748#mechanism-of-action
     -   https://www.uniprot.org/uniprot/P35367#function
 -   directed: true
@@ -66,7 +66,7 @@
         target: MESH:D006969
     -   key: contributes to
         source: MESH:D006969
-        target: MESH:D065631    
+        target: MESH:D065631
     multigraph: true
     nodes:
     -   id: MESH:C004649
@@ -86,8 +86,8 @@
         name: Hypersensitivity, Immediate
     -   id: MESH:D065631
         label: Disease
-        name: Rhinitis, Allergic    
-    reference: 
+        name: Rhinitis, Allergic
+    reference:
     -   https://go.drugbank.com/drugs/DB00748#mechanism-of-action
     -   https://www.uniprot.org/uniprot/P35367#function
 -   directed: true
@@ -112,10 +112,10 @@
         target: GO:0006954
     -   key: caused by
         source: GO:0006954
-        target: NCBITaxon:12058     
+        target: NCBITaxon:12058
     -   key: causes
-        source: NCBITaxon:12058 
-        target: MESH:D003139    
+        source: NCBITaxon:12058
+        target: MESH:D003139
     multigraph: true
     nodes:
     -   id: MESH:C004649
@@ -133,13 +133,13 @@
     -   id: GO:0006954
         label: BiologicalProcess
         name: inflammatory response
-    -   id: NCBITaxon:12058 
+    -   id: NCBITaxon:12058
         label: OrganismTaxon
-        name: Picornaviridae    
+        name: Picornaviridae
     -   id: MESH:D003139
         label: Disease
-        name: Common cold    
-    reference: 
+        name: Common cold
+    reference:
     -   https://go.drugbank.com/drugs/DB00748#mechanism-of-action
     -   https://www.uniprot.org/uniprot/P35367#function
 -   directed: true
@@ -179,7 +179,7 @@
     -   id: MESH:D011537
         label: Disease
         name: Pruritus
-    reference: 
+    reference:
     -   https://go.drugbank.com/drugs/DB00748#mechanism-of-action
     -   https://www.uniprot.org/uniprot/P35367#function
 -   directed: true
@@ -204,7 +204,7 @@
         target: MESH:D006969
     -   key: contributes to
         source: MESH:D006969
-        target: MESH:D006255    
+        target: MESH:D006255
     multigraph: true
     nodes:
     -   id: MESH:C004649
@@ -224,8 +224,8 @@
         name: Hypersensitivity, Immediate
     -   id: MESH:D006255
         label: Disease
-        name: Rhinitis, Allergic, Seasonal    
-    reference: 
+        name: Rhinitis, Allergic, Seasonal   
+    reference:
     -   https://go.drugbank.com/drugs/DB00748#mechanism-of-action
     -   https://www.uniprot.org/uniprot/P35367#function
 -   directed: true
@@ -265,7 +265,7 @@
     -   id: MESH:D014581
         label: Disease
         name: Urticaria
-    reference: 
+    reference:
     -   https://go.drugbank.com/drugs/DB00748#mechanism-of-action
     -   https://www.uniprot.org/uniprot/P35367#function
 -   directed: true
@@ -290,7 +290,7 @@
         target: GO:0006954
     -   key: contributes to
         source: GO:0006954
-        target: MESH:D012223    
+        target: MESH:D012223
     multigraph: true
     nodes:
     -   id: MESH:C004649
@@ -310,8 +310,8 @@
         name: inflammatory response
     -   id: MESH:D012223
         label: Disease
-        name: Rhinitis, Vasomotor    
-    reference: 
+        name: Rhinitis, Vasomotor
+    reference:
     -   https://go.drugbank.com/drugs/DB00748#mechanism-of-action
     -   https://www.uniprot.org/uniprot/P35367#function
 -   directed: true
@@ -342,7 +342,7 @@
         target: MESH:D003924
     -   key: positively correlated with
         source: GO:0070091
-        target: MESH:D003924        
+        target: MESH:D003924
     multigraph: true
     nodes:
     -   id: MESH:C534891
@@ -362,12 +362,12 @@
         name: insulin secretion
     -   id: GO:0070091
         label: BiologicalProcess
-        name: glucagon secretion    
+        name: glucagon secretion
     -   id: MESH:D003924
         label: Disease
         name: Diabetes Mellitus, Type 2
-    reference: 
-    -   https://go.drugbank.com/drugs/DB12412#mechanism-of-action 
+    reference:
+    -   https://go.drugbank.com/drugs/DB12412#mechanism-of-action
     -   https://drugs.ncats.io/drug/5DHU18M5D6#general
     -   https://www.uniprot.org/uniprot/P27487#function
 -   directed: true
@@ -392,7 +392,7 @@
         target: MESH:D059268
     -   key: contributes to
         source: MESH:D059268
-        target: MESH:D004414    
+        target: MESH:D004414
     multigraph: true
     nodes:
     -   id: MESH:C119141
@@ -412,8 +412,8 @@
         name: Atrophic Vaginitis
     -   id: MESH:D004414
         label: Disease
-        name: Dyspareunia    
-    reference: 
+        name: Dyspareunia
+    reference:
     -   https://go.drugbank.com/drugs/DB04938#mechanism-of-action
     -   https://www.uniprot.org/uniprot/P03372#function
     -   https://en.wikipedia.org/wiki/Dyspareunia
@@ -434,12 +434,12 @@
     -   key: negatively correlated with
         source: GO:0038003
         target: GO:0019233
-    -   key: increases abundance of
+    -   key: positively regulates
         source: GO:0019233
         target: MESH:D009619
     -   key: positively correlated with
         source: MESH:D009619
-        target: MESH:D059350    
+        target: MESH:D059350
     multigraph: true
     nodes:
     -   id: MESH:D010111
@@ -459,8 +459,8 @@
         name: Nociceptors
     -   id: MESH:D059350
         label: Disease
-        name: Chronic Pain    
-    reference: 
+        name: Chronic Pain
+    reference:
     -   https://go.drugbank.com/drugs/DB01192#mechanism-of-action
     -   https://www.uniprot.org/uniprot/P35372#function
     -   https://en.wikipedia.org/wiki/Chronic_pain
@@ -481,12 +481,12 @@
     -   key: negatively correlated with
         source: GO:0038003
         target: GO:0019233
-    -   key: increases abundance of
+    -   key: positively regulates
         source: GO:0019233
         target: MESH:D009619
     -   key: positively correlated with
         source: MESH:D009619
-        target: MESH:D048949    
+        target: MESH:D048949
     multigraph: true
     nodes:
     -   id: MESH:D010111
@@ -506,8 +506,8 @@
         name: Nociceptors
     -   id: MESH:D048949
         label: Disease
-        name: Labor Pain    
-    reference: 
+        name: Labor Pain
+    reference:
     -   https://go.drugbank.com/drugs/DB01192#mechanism-of-action
     -   https://www.uniprot.org/uniprot/P35372#function
     -   https://en.wikipedia.org/wiki/Childbirth
@@ -528,12 +528,12 @@
     -   key: negatively correlated with
         source: GO:0038003
         target: GO:0019233
-    -   key: increases abundance of
+    -   key: positively regulates
         source: GO:0019233
         target: MESH:D009619
     -   key: positively correlated with
         source: MESH:D009619
-        target: MESH:D010146    
+        target: MESH:D010146
     multigraph: true
     nodes:
     -   id: MESH:D010111
@@ -553,8 +553,8 @@
         name: Nociceptors
     -   id: MESH:D010146
         label: Disease
-        name: Pain    
-    reference: 
+        name: Pain
+    reference:
     -   https://go.drugbank.com/drugs/DB01192#mechanism-of-action
     -   https://www.uniprot.org/uniprot/P35372#function
     -   https://en.wikipedia.org/wiki/Pain
@@ -583,7 +583,7 @@
         target: UBERON:0002114
     -   key: location of
         source: UBERON:0002114
-        target: MESH:D004381        
+        target: MESH:D004381
     multigraph: true
     nodes:
     -   id: MESH:D011899
@@ -601,13 +601,13 @@
     -   id: MESH:D010437
         label: Disease
         name: Peptic Ulcer
-    -   id: UBERON:0002114 
+    -   id: UBERON:0002114
         label: GrossAnatomicalStructure
-        name: duodenum        
+        name: duodenum
     -   id: MESH:D004381
         label: Disease
         name: Duodenal Ulcer
-    reference: 
+    reference:
     -   https://go.drugbank.com/drugs/DB00863#mechanism-of-action
     -   https://www.uniprot.org/uniprot/P25021#function
 -   directed: true
@@ -635,7 +635,7 @@
         target: UBERON:0000945
     -   key: location of
         source: UBERON:0000945
-        target: MESH:D013276        
+        target: MESH:D013276
     multigraph: true
     nodes:
     -   id: MESH:D011899
@@ -653,13 +653,13 @@
     -   id: MESH:D010437
         label: Disease
         name: Peptic Ulcer
-    -   id: UBERON:0000945 
+    -   id: UBERON:0000945
         label: GrossAnatomicalStructure
-        name: stomach        
+        name: stomach
     -   id: MESH:D013276
         label: Disease
         name: Stomach Ulcer
-    reference: 
+    reference:
     -   https://go.drugbank.com/drugs/DB00863#mechanism-of-action
     -   https://www.uniprot.org/uniprot/P25021#function
 -   directed: true
@@ -678,7 +678,7 @@
         target: GO:0001696
     -   key: increases abundance of
         source: GO:0001696
-        target: MESH:D005744    
+        target: MESH:D005744
     -   key: contributes to
         source: MESH:D005744
         target: MESH:D005764
@@ -695,11 +695,11 @@
         name: gastric acid secretion
     -   id: MESH:D005744
         label: ChemicalSubstance
-        name: Gastric Acid    
+        name: Gastric Acid
     -   id: MESH:D005764
         label: Disease
         name: Gastroesophageal Reflux
-    reference: 
+    reference:
     -   https://go.drugbank.com/drugs/DB00863#mechanism-of-action
     -   https://www.uniprot.org/uniprot/P25021#function
     -   https://en.wikipedia.org/wiki/Gastroesophageal_reflux_disease
@@ -719,7 +719,7 @@
         target: GO:0001696
     -   key: increases abundance of
         source: GO:0001696
-        target: MESH:D005744    
+        target: MESH:D005744
     -   key: contributes to
         source: MESH:D005744
         target: MESH:D006356
@@ -736,11 +736,11 @@
         name: gastric acid secretion
     -   id: MESH:D005744
         label: ChemicalSubstance
-        name: Gastric Acid    
+        name: Gastric Acid
     -   id: MESH:D006356
         label: Disease
         name: Heartburn
-    reference: 
+    reference:
     -   https://go.drugbank.com/drugs/DB00863#mechanism-of-action
     -   https://www.uniprot.org/uniprot/P25021#function
     -   https://en.wikipedia.org/wiki/Heartburn
@@ -763,7 +763,7 @@
         target: MESH:D005744
     -   key: contributes to
         source: MESH:D005744
-        target: MESH:D006356    
+        target: MESH:D006356
     -   key: manifestation of
         source: MESH:D006356
         target: MESH:D004415
@@ -783,11 +783,11 @@
         name: Gastric Acid
     -   id: MESH:D006356
         label: Disease
-        name: Heartburn    
+        name: Heartburn
     -   id: MESH:D004415
         label: Disease
         name: Dyspepsia
-    reference: 
+    reference:
     -   https://go.drugbank.com/drugs/DB00863#mechanism-of-action
     -   https://www.uniprot.org/uniprot/P25021#function
     -   https://en.wikipedia.org/wiki/Indigestion
@@ -810,7 +810,7 @@
         target: MESH:D005744
     -   key: contributes to
         source: MESH:D005744
-        target: MESH:D010437    
+        target: MESH:D010437
     -   key: manifestation of
         source: MESH:D010437
         target: MESH:D015043
@@ -830,11 +830,11 @@
         name: Gastric Acid
     -   id: MESH:D010437
         label: Disease
-        name: Peptic Ulcer    
+        name: Peptic Ulcer
     -   id: MESH:D015043
         label: Disease
         name: Zollinger-Ellison Syndrome
-    reference: 
+    reference:
     -   https://go.drugbank.com/drugs/DB00863#mechanism-of-action
     -   https://www.uniprot.org/uniprot/P25021#function
     -   https://en.wikipedia.org/wiki/Zollinger%E2%80%93Ellison_syndrome
@@ -851,13 +851,13 @@
         target: UniProt:P22303
     -   key: decreases activity of
         source: MESH:D000068836
-        target: MESH:D002091    
+        target: MESH:D002091
     -   key: participates in
         source: UniProt:P22303
         target: GO:0001507
     -   key: participates in
         source: MESH:D002091
-        target: GO:0001507    
+        target: GO:0001507
     -   key: decreases abundance of
         source: GO:0001507
         target: MESH:D000109
@@ -883,8 +883,8 @@
         name: Acetylcholine
     -   id: MESH:D000544
         label: Disease
-        name: Alzheimer Disease    
-    reference: 
+        name: Alzheimer Disease
+    reference:
     -   https://go.drugbank.com/drugs/DB00989#mechanism-of-action
     -   https://www.uniprot.org/uniprot/P22303#function
     -   https://en.wikipedia.org/wiki/Alzheimer%27s_disease
@@ -901,7 +901,7 @@
         target: UniProt:P31645
     -   key: decreases activity of
         source: MESH:D014196
-        target: InterPro:IPR002231 
+        target: InterPro:IPR002231
     -   key: participates in
         source: UniProt:P31645
         target: GO:0051610
@@ -916,7 +916,7 @@
         target: GO:0060096
     -   key: negatively regulates
         source: GO:0060096
-        target: MESH:D003865    
+        target: MESH:D003865
     multigraph: true
     nodes:
     -   id: MESH:D014196
@@ -936,12 +936,12 @@
         name: Serotonin
     -   id: GO:0060096
         label: BiologicalProcess
-        name: serotonin secretion, neurotransmission    
+        name: serotonin secretion, neurotransmission  
     -   id: MESH:D003865
         label: Disease
         name: Depressive Disorder, Major
-    reference: 
+    reference:
     -   https://go.drugbank.com/drugs/DB00656#mechanism-of-action
     -   https://www.ebi.ac.uk/interpro/entry/InterPro/IPR002231/
     -   https://www.uniprot.org/uniprot/P31645#function
-    -   https://en.wikipedia.org/wiki/Major_depressive_disorder                                                
+    -   https://en.wikipedia.org/wiki/Major_depressive_disorder