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"_id": "DB11611_MESH_D015352_1", + "disease": "Tear film insufficiency", + "disease_mesh": "MESH:D015352", + "drug": "lifitegrast", + "drug_mesh": "MESH:C575157", + "drugbank": "DB:DB11611" + }, + "links": [ + { + "key": "decreases activity of", + "source": "MESH:C575157", + "target": "UniProt:P20701" + }, + { + "key": "positively correlated with", + "source": "UniProt:P20701", + "target": "GO:0042110" + }, + { + "key": "positively correlated with", + "source": "UniProt:P20701", + "target": "GO:0042098" + }, + { + "key": "positively correlated with", + "source": "GO:0042110", + "target": "GO:0006954" + }, + { + "key": "positively correlated with", + "source": "GO:0042098", + "target": "GO:0006954" + }, + { + "key": "occurs in", + "source": "GO:0006954", + "target": "MESH:D015352" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:C575157", + "label": "Drug", + "name": "Lifitegrast" + }, + { + "id": "UniProt:P20701", + "label": "Protein", + "name": "Integrin alpha-L" + }, + { + "id": "GO:0042098", + "label": "BiologicalProcess", + "name": "T cell proliferation" + }, + { + "id": "GO:0042110", + "label": "BiologicalProcess", + "name": "T cell activation" + }, + { + "id": "GO:0006954", + "label": "BiologicalProcess", + "name": "Inflammatory response" + }, + { + "id": "MESH:D015352", + "label": "Disease", + "name": "Tear film insufficiency" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB11611", + "https://en.wikipedia.org/wiki/Lifitegrast" + ] + }, + { + "directed": true, + "graph": { + "_id": "DB12148_MESH_D006475_1", + "disease": "Hemorrhagic disease of the newborn due to vitamin K deficiency", + "disease_mesh": "MESH:D006475", + "drug": "menatetrenone", + "drug_mesh": "MESH:C030814", + "drugbank": "DB:DB12148" + }, + "links": [ + { + "key": "increases activity of", + "source": "MESH:C030814", + "target": "UniProt:P38435" + }, + { + "key": "positively regulates", + "source": "UniProt:P38435", + "target": "GO:0007596" + }, + { + "key": "negatively correlated with", + "source": "GO:0007596", + "target": "MESH:D006475" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:C030814", + "label": "Drug", + "name": "Menatetrenone" + }, + { + "id": "UniProt:P38435", + "label": "Protein", + "name": "Vitamin K-dependent gamma-carboxylase" + }, + { + "id": "GO:0007596", + "label": "BiologicalProcess", + "name": "Blood coagulation" + }, + { + "id": "MESH:D006475", + "label": "Disease", + "name": "Hemorrhagic disease of the newborn due to vitamin K deficiency" + } + ], + "reference": [ + "https://en.wikipedia.org/wiki/Vitamin_K2#Mechanism_of_action" + ] } ] \ No newline at end of file diff --git a/indication_paths.yaml b/indication_paths.yaml index 0cbdcb1c1..c5d21cc74 100644 --- a/indication_paths.yaml +++ b/indication_paths.yaml @@ -149093,3 +149093,1615 @@ name: Rheumatism reference: - https://go.drugbank.com/drugs/DB13783 +- directed: true + graph: + _id: DB00041_MESH_D015470_1 + disease: Acute myeloid leukemia, disease + disease_mesh: MESH:D015470 + drug: aldesleukin + drug_mesh: MESH:C082598 + drugbank: DB:DB00041 + links: + - key: increases activity of + source: MESH:C082598 + target: UniProt:P14784 + - key: positively regulates + source: UniProt:P14784 + target: GO:0038110 + - key: increases activity of + source: MESH:C082598 + target: UniProt:P01589 + - key: positively regulates + source: UniProt:P01589 + target: GO:0038110 + - key: positively regulates + source: GO:0038110 + target: GO:0045065 + - key: positively regulates + source: GO:0038110 + target: GO:0030101 + - key: treats + source: GO:0045065 + target: MESH:D015470 + - key: treats + source: GO:0030101 + target: MESH:D015470 + multigraph: true + nodes: + - id: MESH:C082598 + label: Drug + name: Aldesleukin + - id: UniProt:P14784 + label: Protein + name: Interleukin-2 receptor subunit beta + - id: UniProt:P01589 + label: Protein + name: Interleukin-2 receptor subunit alpha + - id: GO:0038110 + label: BiologicalProcess + name: Interleukin-2-mediated signaling pathway + - id: GO:0045065 + label: BiologicalProcess + name: Cytotoxic T cell differentiation + - id: GO:0030101 + label: BiologicalProcess + name: Natural killer cell activation + - id: MESH:D015470 + label: Disease + name: Acute myeloid leukemia, disease + reference: + - https://go.drugbank.com/drugs/DB00041 +- directed: true + graph: + _id: DB00346_MESH_D011470_1 + disease: Benign prostatic hyperplasia + disease_mesh: MESH:D011470 + drug: alfuzosin + drug_mesh: MESH:C047638 + drugbank: DB:DB00346 + links: + - key: decreases activity of + source: MESH:C047638 + target: UniProt:P35348 + - key: decreases activity of + source: MESH:C047638 + target: UniProt:P35368 + - key: decreases activity of + source: MESH:C047638 + target: UniProt:P25100 + - key: positively regulates + source: UniProt:P35348 + target: GO:0014832 + - key: positively regulates + source: UniProt:P35368 + target: GO:0014832 + - key: positively regulates + source: UniProt:P25100 + target: GO:0014832 + - key: positively correlated with + source: GO:0014832 + target: HP:0100515 + - key: manifestation of + source: HP:0100515 + target: MESH:D011470 + multigraph: true + nodes: + - id: MESH:C047638 + label: Drug + name: Alfuzosin + - id: UniProt:P35348 + label: Protein + name: Alpha-1A adrenergic receptor + - id: UniProt:P35368 + label: Protein + name: Alpha-1B adrenergic receptor + - id: UniProt:P25100 + label: Protein + name: Alpha-1D adrenergic receptor + - id: GO:0014832 + label: BiologicalProcess + name: Urinary bladder smooth muscle contraction + - id: HP:0100515 + label: PhenotypicFeature + name: Pollakisuria + - id: MESH:D011470 + label: Disease + name: Benign prostatic hyperplasia + reference: + - https://go.drugbank.com/drugs/DB00346 +- directed: true + graph: + _id: DB00637_MESH_D012912_1 + disease: Sneezing + disease_mesh: MESH:D012912 + drug: astemizole + drug_mesh: MESH:D016589 + drugbank: DB:DB00637 + links: + - key: decreases activity of + source: MESH:D016589 + target: UniProt:P35367 + - key: participates in + source: UniProt:P35367 + target: GO:0051381 + - key: positively regulates + source: GO:0051381 + target: GO:0023041 + - key: located in + source: GO:0023041 + target: UBERON:0000004 + - key: affected by + source: UBERON:0000004 + target: UBERON:0001645 + - key: contributes to + source: UBERON:0001645 + target: MESH:D012912 + multigraph: true + nodes: + - id: MESH:D016589 + label: Drug + name: Astemizole + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: GO:0051381 + label: MolecularActivity + name: Histamine binding + - id: GO:0023041 + label: BiologicalProcess + name: Neuronal signal transduction + - id: UBERON:0000004 + label: GrossAnatomicalStructure + name: Nose + - id: UBERON:0001645 + label: GrossAnatomicalStructure + name: Trigeminal nerve + - id: MESH:D012912 + label: Disease + name: Sneezing + reference: + - https://go.drugbank.com/drugs/DB00637 + - https://en.wikipedia.org/wiki/Sneeze +- directed: true + graph: + _id: DB00637_MESH_D003233_1 + disease: Allergic conjunctivitis + disease_mesh: MESH:D003233 + drug: astemizole + drug_mesh: MESH:D016589 + drugbank: DB:DB00637 + links: + - key: negatively regulates + source: MESH:D016589 + target: UniProt:P35367 + - key: positively regulates + source: UniProt:P35367 + target: GO:0004969 + - key: participates in + source: GO:0004969 + target: GO:0071420 + - key: positively correlated with + source: GO:0071420 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D003233 + multigraph: true + nodes: + - id: MESH:D016589 + label: Drug + name: Astemizole + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: GO:0004969 + label: MolecularActivity + name: Histamine receptor activity + - id: GO:0071420 + label: BiologicalProcess + name: Cellular response to histamine + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D003233 + label: Disease + name: Allergic conjunctivitis + reference: + - https://go.drugbank.com/drugs/DB00637 +- directed: true + graph: + _id: DB00637_MESH_D000080223_1 + disease: Chronic idiopathic urticaria + disease_mesh: MESH:D000080223 + drug: Astemizole + drug_mesh: MESH:D016589 + drugbank: DB:DB00637 + links: + - key: decreases activity of + source: MESH:D016589 + target: UniProt:P35367 + - key: positively regulates + source: UniProt:P35367 + target: GO:0004969 + - key: participates in + source: GO:0004969 + target: GO:0071420 + - key: positively correlated with + source: GO:0071420 + target: GO:0006954 + - key: positively correlated with + source: GO:0071420 + target: GO:0043117 + - key: positively correlated with + source: GO:0071420 + target: HP:0000969 + - key: manifestation of + source: HP:0000969 + target: MESH:D000080223 + - key: manifestation of + source: GO:0043117 + target: MESH:D000080223 + - key: causes + source: GO:0006954 + target: MESH:D000080223 + multigraph: true + nodes: + - id: MESH:D016589 + label: Drug + name: Astemizole + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: GO:0004969 + label: MolecularActivity + name: Histamine receptor activity + - id: GO:0071420 + label: BiologicalProcess + name: Cellular response to histamine + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: GO:0043117 + label: BiologicalProcess + name: Positive regulation of vascular permeability + - id: HP:0000969 + label: PhenotypicFeature + name: Edema + - id: MESH:D000080223 + label: Disease + name: Chronic idiopathic urticaria + reference: + - https://go.drugbank.com/drugs/DB00637 +- directed: true + graph: + _id: DB00637_MESH_D065631_1 + disease: Allergic rhinitis + disease_mesh: MESH:D065631 + drug: Astemizole + drug_mesh: MESH:D016589 + drugbank: DB:DB00637 + links: + - key: decreases activity of + source: MESH:D016589 + target: UniProt:P35367 + - key: positively regulates + source: UniProt:P35367 + target: GO:0004969 + - key: participates in + source: GO:0004969 + target: GO:0071420 + - key: positively correlated with + source: GO:0071420 + target: GO:0006954 + - key: has phenotype + source: GO:0006954 + target: HP:0031417 + - key: manifestation of + source: HP:0031417 + target: MESH:D065631 + multigraph: true + nodes: + - id: MESH:D016589 + label: Drug + name: Astemizole + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: GO:0004969 + label: MolecularActivity + name: Histamine receptor activity + - id: GO:0071420 + label: BiologicalProcess + name: Cellular response to histamine + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: HP:0031417 + label: PhenotypicFeature + name: Rhinorrhea + - id: MESH:D065631 + label: Disease + name: Allergic rhinitis + reference: + - https://go.drugbank.com/drugs/DB00637 +- directed: true + graph: + _id: DB01047_MESH_D016410_1 + disease: Primary cutaneous T-cell lymphoma + disease_mesh: MESH:D016410 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB01047 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: has phenotype + source: GO:0006954 + target: HP:0000989 + - key: has phenotype + source: GO:0006954 + target: HP:0000988 + - key: manifestation of + source: HP:0000989 + target: MESH:D016410 + - key: manifestation of + source: HP:0000988 + target: MESH:D016410 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: HP:0000989 + label: PhenotypicFeature + name: Pruritus + - id: HP:0000988 + label: PhenotypicFeature + name: Skin rash + - id: MESH:D016410 + label: Disease + name: Primary cutaneous T-cell lymphoma + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + _id: DB01047_MESH_D008179_1 + disease: Discoid lupus erythematosus + disease_mesh: MESH:D008179 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB01047 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: positively correlated with + source: GO:0006954 + target: MESH:D008179 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D008179 + label: Disease + name: Discoid lupus erythematosus + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + _id: DB01047_MESH_D011538_1 + disease: Pruritus ani + disease_mesh: MESH:D011538 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB01047 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: has phenotype + source: GO:0006954 + target: HP:0000989 + - key: manifestation of + source: HP:0000989 + target: MESH:D011538 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: HP:0000989 + label: PhenotypicFeature + name: Pruritus + - id: MESH:D011538 + label: Disease + name: Pruritus ani + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + _id: DB01047_MESH_D016460_1 + disease: Granuloma annulare + disease_mesh: MESH:D016460 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB01047 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: positively correlated with + source: GO:0006954 + target: MESH:D016460 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D016460 + label: Disease + name: Granuloma annulare + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + _id: DB01047_MESH_D005076_1 + disease: Eruption of skin + disease_mesh: MESH:D005076 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB01047 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: positively correlated with + source: GO:0006954 + target: MESH:D005076 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D005076 + label: Disease + name: Eruption of skin + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + _id: DB01047_MESH_D003877_1 + disease: Contact dermatitis + disease_mesh: MESH:D003877 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB01047 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: positively correlated with + source: GO:0006954 + target: MESH:D003877 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D003877 + label: Disease + name: Contact dermatitis + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + _id: DB010473_MESH_D012628_1 + disease: Seborrheic dermatitis + disease_mesh: MESH:D012628 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB010473 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: has phenotype + source: GO:0006954 + target: HP:0000989 + - key: manifestation of + source: HP:0000989 + target: MESH:D012628 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: HP:0000989 + label: PhenotypicFeature + name: Pruritus + - id: MESH:D012628 + label: Disease + name: Seborrheic dermatitis + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + _id: DB010473_MESH_D009450_1 + disease: Lichen simplex chronicus + disease_mesh: MESH:D009450 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB010473 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: has phenotype + source: GO:0006954 + target: HP:0000989 + - key: manifestation of + source: HP:0000989 + target: MESH:D009450 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: HP:0000989 + label: PhenotypicFeature + name: Pruritus + - id: MESH:D009450 + label: Disease + name: Lichen simplex chronicus + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + _id: DB010473_MESH_D003876_1 + disease: Atopic dermatitis + disease_mesh: MESH:D003876 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB010473 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: has phenotype + source: GO:0006954 + target: HP:0000989 + - key: has phenotype + source: GO:0006954 + target: HP:0000969 + - key: manifestation of + source: HP:0000989 + target: MESH:D003876 + - key: manifestation of + source: HP:0000969 + target: MESH:D003876 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: HP:0000989 + label: PhenotypicFeature + name: Pruritus + - id: HP:0000969 + label: PhenotypicFeature + name: Edema + - id: MESH:D003876 + label: Disease + name: Atopic dermatitis + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + _id: DB01356_MESH_D001714_1 + disease: Bipolar disorder + disease_mesh: MESH:D001714 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: MESH:D001714 + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P4984 + - key: positively correlated with + source: UniProt:P4984 + target: HP:0000713 + - key: occurs in + source: HP:0000713 + target: MESH:D001714 + - key: positively regulates + source: MESH:D016651 + target: GO:0061534 + - key: negatively correlated with + source: GO:0061534 + target: MESH:D001714 + - key: negatively regulates + source: MESH:D016651 + target: GO:0061527 + - key: positively correlated with + source: GO:0061527 + target: MESH:D001714 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: MESH:D001714 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: UniProt:P4984 + label: Protein + name: Glycogen synthase kinase-3 beta + - id: HP:0000713 + label: PhenotypicFeature + name: Agitation + - id: GO:0061534 + label: BiologicalProcess + name: Gamma-aminobutyric acid secretion, neurotransmission + - id: GO:0061527 + label: BiologicalProcess + name: Dopamine secretion, neurotransmission + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: MESH:D001714 + label: Disease + name: Bipolar disorder + reference: + - https://pubmed.ncbi.nlm.nih.gov/23371914/ + - https://go.drugbank.com/drugs/DB14509 + - https://en.wikipedia.org/wiki/Lithium_(medication)#Bipolar_disorder +- directed: true + graph: + _id: DB01356_MESH_D020773_1 + disease: Headache disorder + disease_mesh: MESH:D020773 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: GO:0019233 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: GO:0061535 + - key: positively correlated with + source: GO:0061535 + target: GO:0019233 + - key: positively correlated with + source: GO:0019233 + target: MESH:D020773 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: GO:0019233 + label: BiologicalProcess + name: Sensory perception of pain + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: GO:0061535 + label: BiologicalProcess + name: Glutamate secretion, neurotransmission + - id: MESH:D020773 + label: Disease + name: Headache disorder + reference: + - https://go.drugbank.com/drugs/DB14509 +- directed: true + graph: + _id: DB01356_MESH_D010146_1 + disease: Pain + disease_mesh: MESH:D010146 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: GO:0019233 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: GO:0061535 + - key: positively correlated with + source: GO:0061535 + target: GO:0019233 + - key: positively correlated with + source: GO:0019233 + target: MESH:D010146 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: GO:0019233 + label: BiologicalProcess + name: Sensory perception of pain + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: GO:0061535 + label: BiologicalProcess + name: Glutamate secretion, neurotransmission + - id: MESH:D010146 + label: Disease + name: Pain + reference: + - https://go.drugbank.com/drugs/DB14509 +- comment: Lithium can cause side effects such as fever. + directed: true + graph: + _id: DB01356_MESH_D005334_1 + disease: Fever + disease_mesh: MESH:D005334 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: causes + source: MESH:D016651 + target: MESH:D005334 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: MESH:D005334 + label: Disease + name: Fever + reference: + - https://en.wikipedia.org/wiki/Lithium_toxicity + - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164879/ +- directed: true + graph: + _id: DB01356_MESH_D010003_1 + disease: Osteoarthritis + disease_mesh: MESH:D010003 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: GO:0019233 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: GO:0061535 + - key: positively correlated with + source: GO:0061535 + target: GO:0019233 + - key: positively correlated with + source: GO:0019233 + target: MESH:D010003 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: GO:0019233 + label: BiologicalProcess + name: Sensory perception of pain + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: GO:0061535 + label: BiologicalProcess + name: Glutamate secretion, neurotransmission + - id: MESH:D010003 + label: Disease + name: Osteoarthritis + reference: + - https://go.drugbank.com/drugs/DB14509 +- directed: true + graph: + _id: DB01356_MESH_D001171_1 + disease: Juvenile rheumatoid arthritis + disease_mesh: MESH:D001171 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: GO:0019233 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: GO:0061535 + - key: positively correlated with + source: GO:0061535 + target: GO:0019233 + - key: positively correlated with + source: GO:0019233 + target: MESH:D001171 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: GO:0019233 + label: BiologicalProcess + name: Sensory perception of pain + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: GO:0061535 + label: BiologicalProcess + name: Glutamate secretion, neurotransmission + - id: MESH:D001171 + label: Disease + name: Juvenile rheumatoid arthritis + reference: + - https://go.drugbank.com/drugs/DB14509 +- directed: true + graph: + _id: DB01356_MESH_D001172_1 + disease: Rheumatoid arthritis + disease_mesh: MESH:D001172 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: GO:0019233 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: GO:0061535 + - key: positively correlated with + source: GO:0061535 + target: GO:0019233 + - key: positively correlated with + source: GO:0019233 + target: MESH:D001172 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: GO:0019233 + label: BiologicalProcess + name: Sensory perception of pain + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: GO:0061535 + label: BiologicalProcess + name: Glutamate secretion, neurotransmission + - id: MESH:D001172 + label: Disease + name: Rheumatoid arthritis + reference: + - https://go.drugbank.com/drugs/DB14509 +- directed: true + graph: + _id: DB01356_MESH_D004412_1 + disease: Dysmenorrhea + disease_mesh: MESH:D004412 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: GO:0019233 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: GO:0061535 + - key: positively correlated with + source: GO:0061535 + target: GO:0019233 + - key: positively correlated with + source: GO:0019233 + target: MESH:D004412 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: GO:0019233 + label: BiologicalProcess + name: Sensory perception of pain + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: GO:0061535 + label: BiologicalProcess + name: Glutamate secretion, neurotransmission + - id: MESH:D004412 + label: Disease + name: Dysmenorrhea + reference: + - https://go.drugbank.com/drugs/DB14509 +- directed: true + graph: + _id: DB11611_MESH_D015352_1 + disease: Tear film insufficiency + disease_mesh: MESH:D015352 + drug: lifitegrast + drug_mesh: MESH:C575157 + drugbank: DB:DB11611 + links: + - key: decreases activity of + source: MESH:C575157 + target: UniProt:P20701 + - key: positively correlated with + source: UniProt:P20701 + target: GO:0042110 + - key: positively correlated with + source: UniProt:P20701 + target: GO:0042098 + - key: positively correlated with + source: GO:0042110 + target: GO:0006954 + - key: positively correlated with + source: GO:0042098 + target: GO:0006954 + - key: occurs in + source: GO:0006954 + target: MESH:D015352 + multigraph: true + nodes: + - id: MESH:C575157 + label: Drug + name: Lifitegrast + - id: UniProt:P20701 + label: Protein + name: Integrin alpha-L + - id: GO:0042098 + label: BiologicalProcess + name: T cell proliferation + - id: GO:0042110 + label: BiologicalProcess + name: T cell activation + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D015352 + label: Disease + name: Tear film insufficiency + reference: + - https://go.drugbank.com/drugs/DB11611 + - https://en.wikipedia.org/wiki/Lifitegrast +- directed: true + graph: + _id: DB12148_MESH_D006475_1 + disease: Hemorrhagic disease of the newborn due to vitamin K deficiency + disease_mesh: MESH:D006475 + drug: menatetrenone + drug_mesh: MESH:C030814 + drugbank: DB:DB12148 + links: + - key: increases activity of + source: MESH:C030814 + target: UniProt:P38435 + - key: positively regulates + source: UniProt:P38435 + target: GO:0007596 + - key: negatively correlated with + source: GO:0007596 + target: MESH:D006475 + multigraph: true + nodes: + - id: MESH:C030814 + label: Drug + name: Menatetrenone + - id: UniProt:P38435 + label: Protein + name: Vitamin K-dependent gamma-carboxylase + - id: GO:0007596 + label: BiologicalProcess + name: Blood coagulation + - id: MESH:D006475 + label: Disease + name: Hemorrhagic disease of the newborn due to vitamin K deficiency + reference: + - https://en.wikipedia.org/wiki/Vitamin_K2#Mechanism_of_action