From 94b81e51dabd4b9041f81d609fc4f8dca7216759 Mon Sep 17 00:00:00 2001 From: AnnaTanska <65995337+TanskaAnnna@users.noreply.github.com> Date: Wed, 23 Jun 2021 14:38:06 +0200 Subject: [PATCH 1/2] Group 123 --- submission.yaml | 1588 ++++++++++++++++++++++++++++++++++++++++++++++- 1 file changed, 1587 insertions(+), 1 deletion(-) diff --git a/submission.yaml b/submission.yaml index 8b1378917..fa28f9b9d 100644 --- a/submission.yaml +++ b/submission.yaml @@ -1 +1,1587 @@ - +- directed: true + graph: + disease: Acute myeloid leukemia, disease + disease_mesh: MESH:D015470 + drug: aldesleukin + drug_mesh: MESH:C082598 + drugbank: DB:DB00041 + links: + - key: increases activity of + source: MESH:C082598 + target: UniProt:P14784 + - key: positively regulates + source: UniProt:P14784 + target: GO:0038110 + - key: increases activity of + source: MESH:C082598 + target: UniProt:P01589 + - key: positively regulates + source: UniProt:P01589 + target: GO:0038110 + - key: positively regulates + source: GO:0038110 + target: GO:0045065 + - key: positively regulates + source: GO:0038110 + target: GO:0030101 + - key: treats + source: GO:0045065 + target: MESH:D015470 + - key: treats + source: GO:0030101 + target: MESH:D015470 + multigraph: true + nodes: + - id: MESH:C082598 + label: Drug + name: Aldesleukin + - id: UniProt:P14784 + label: Protein + name: Interleukin-2 receptor subunit beta + - id: UniProt:P01589 + label: Protein + name: Interleukin-2 receptor subunit alpha + - id: GO:0038110 + label: BiologicalProcess + name: Interleukin-2-mediated signaling pathway + - id: GO:0045065 + label: BiologicalProcess + name: Cytotoxic T cell differentiation + - id: GO:0030101 + label: BiologicalProcess + name: Natural killer cell activation + - id: MESH:D015470 + label: Disease + name: Acute myeloid leukemia, disease + reference: + - https://go.drugbank.com/drugs/DB00041 +- directed: true + graph: + disease: Benign prostatic hyperplasia + disease_mesh: MESH:D011470 + drug: alfuzosin + drug_mesh: MESH:C047638 + drugbank: DB:DB00346 + links: + - key: decreases activity of + source: MESH:C047638 + target: UniProt:P35348 + - key: decreases activity of + source: MESH:C047638 + target: UniProt:P35368 + - key: decreases activity of + source: MESH:C047638 + target: UniProt:P25100 + - key: positively regulates + source: UniProt:P35348 + target: GO:0014832 + - key: positively regulates + source: UniProt:P35368 + target: GO:0014832 + - key: positively regulates + source: UniProt:P25100 + target: GO:0014832 + - key: positively correlated with + source: GO:0014832 + target: HP:0100515 + - key: manifestation of + source: HP:0100515 + target: MESH:D011470 + multigraph: true + nodes: + - id: MESH:C047638 + label: Drug + name: Alfuzosin + - id: UniProt:P35348 + label: Protein + name: Alpha-1A adrenergic receptor + - id: UniProt:P35368 + label: Protein + name: Alpha-1B adrenergic receptor + - id: UniProt:P25100 + label: Protein + name: Alpha-1D adrenergic receptor + - id: GO:0014832 + label: BiologicalProcess + name: Urinary bladder smooth muscle contraction + - id: HP:0100515 + label: PhenotypicFeature + name: Pollakisuria + - id: MESH:D011470 + label: Disease + name: Benign prostatic hyperplasia + reference: + - https://go.drugbank.com/drugs/DB00346 +- directed: true + graph: + disease: Sneezing + disease_mesh: MESH:D012912 + drug: astemizole + drug_mesh: MESH:D016589 + drugbank: DB:DB00637 + links: + - key: decreases activity of + source: MESH:D016589 + target: UniProt:P35367 + - key: participates in + source: UniProt:P35367 + target: GO:0051381 + - key: positively regulates + source: GO:0051381 + target: GO:0023041 + - key: located in + source: GO:0023041 + target: UBERON:0000004 + - key: affected by + source: UBERON:0000004 + target: UBERON:0001645 + - key: contributes to + source: UBERON:0001645 + target: MESH:D012912 + multigraph: true + nodes: + - id: MESH:D016589 + label: Drug + name: Astemizole + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: GO:0051381 + label: MolecularActivity + name: Histamine binding + - id: GO:0023041 + label: BiologicalProcess + name: Neuronal signal transduction + - id: UBERON:0000004 + label: GrossAnatomicalStructure + name: Nose + - id: UBERON:0001645 + label: GrossAnatomicalStructure + name: Trigeminal nerve + - id: MESH:D012912 + label: Disease + name: Sneezing + reference: + - https://go.drugbank.com/drugs/DB00637 + - https://en.wikipedia.org/wiki/Sneeze +- directed: true + graph: + disease: Allergic conjunctivitis + disease_mesh: MESH:D003233 + drug: astemizole + drug_mesh: MESH:D016589 + drugbank: DB:DB00637 + links: + - key: negatively regulates + source: MESH:D016589 + target: UniProt:P35367 + - key: positively regulates + source: UniProt:P35367 + target: GO:0004969 + - key: participates in + source: GO:0004969 + target: GO:0071420 + - key: positively correlated with + source: GO:0071420 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D003233 + multigraph: true + nodes: + - id: MESH:D016589 + label: Drug + name: Astemizole + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: GO:0004969 + label: MolecularActivity + name: Histamine receptor activity + - id: GO:0071420 + label: BiologicalProcess + name: Cellular response to histamine + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D003233 + label: Disease + name: Allergic conjunctivitis + reference: + - https://go.drugbank.com/drugs/DB00637 +- directed: true + graph: + disease: Chronic idiopathic urticaria + disease_mesh: MESH:D000080223 + drug: Astemizole + drug_mesh: MESH:D016589 + drugbank: DB:DB00637 + links: + - key: decreases activity of + source: MESH:D016589 + target: UniProt:P35367 + - key: positively regulates + source: UniProt:P35367 + target: GO:0004969 + - key: participates in + source: GO:0004969 + target: GO:0071420 + - key: positively correlated with + source: GO:0071420 + target: GO:0006954 + - key: positively correlated with + source: GO:0071420 + target: GO:0043117 + - key: positively correlated with + source: GO:0071420 + target: HP:0000969 + - key: manifestation of + source: HP:0000969 + target: MESH:D000080223 + - key: manifestation of + source: GO:0043117 + target: MESH:D000080223 + - key: causes + source: GO:0006954 + target: MESH:D000080223 + multigraph: true + nodes: + - id: MESH:D016589 + label: Drug + name: Astemizole + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: GO:0004969 + label: MolecularActivity + name: Histamine receptor activity + - id: GO:0071420 + label: BiologicalProcess + name: Cellular response to histamine + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: GO:0043117 + label: BiologicalProcess + name: Positive regulation of vascular permeability + - id: HP:0000969 + label: PhenotypicFeature + name: Edema + - id: MESH:D000080223 + label: Disease + name: Chronic idiopathic urticaria + reference: + - https://go.drugbank.com/drugs/DB00637 +- directed: true + graph: + disease: Allergic rhinitis + disease_mesh: MESH:D065631 + drug: Astemizole + drug_mesh: MESH:D016589 + drugbank: DB:DB00637 + links: + - key: decreases activity of + source: MESH:D016589 + target: UniProt:P35367 + - key: positively regulates + source: UniProt:P35367 + target: GO:0004969 + - key: participates in + source: GO:0004969 + target: GO:0071420 + - key: positively correlated with + source: GO:0071420 + target: GO:0006954 + - key: has phenotype + source: GO:0006954 + target: HP:0031417 + - key: manifestation of + source: HP:0031417 + target: MESH:D065631 + multigraph: true + nodes: + - id: MESH:D016589 + label: Drug + name: Astemizole + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: GO:0004969 + label: MolecularActivity + name: Histamine receptor activity + - id: GO:0071420 + label: BiologicalProcess + name: Cellular response to histamine + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: HP:0031417 + label: PhenotypicFeature + name: Rhinorrhea + - id: MESH:D065631 + label: Disease + name: Allergic rhinitis + reference: + - https://go.drugbank.com/drugs/DB00637 +- directed: true + graph: + disease: Primary cutaneous T-cell lymphoma + disease_mesh: MESH:D016410 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB01047 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: has phenotype + source: GO:0006954 + target: HP:0000989 + - key: has phenotype + source: GO:0006954 + target: HP:0000988 + - key: manifestation of + source: HP:0000989 + target: MESH:D016410 + - key: manifestation of + source: HP:0000988 + target: MESH:D016410 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: HP:0000989 + label: PhenotypicFeature + name: Pruritus + - id: HP:0000988 + label: PhenotypicFeature + name: Skin rash + - id: MESH:D016410 + label: Disease + name: Primary cutaneous T-cell lymphoma + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + disease: Discoid lupus erythematosus + disease_mesh: MESH:D008179 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB01047 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: positively correlated with + source: GO:0006954 + target: MESH:D008179 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D008179 + label: Disease + name: Discoid lupus erythematosus + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + disease: Pruritus ani + disease_mesh: MESH:D011538 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB01047 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: has phenotype + source: GO:0006954 + target: HP:0000989 + - key: manifestation of + source: HP:0000989 + target: MESH:D011538 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: HP:0000989 + label: PhenotypicFeature + name: Pruritus + - id: MESH:D011538 + label: Disease + name: Pruritus ani + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + disease: Granuloma annulare + disease_mesh: MESH:D016460 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB01047 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: positively correlated with + source: GO:0006954 + target: MESH:D016460 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D016460 + label: Disease + name: Granuloma annulare + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + disease: Eruption of skin + disease_mesh: MESH:D005076 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB01047 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: positively correlated with + source: GO:0006954 + target: MESH:D005076 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D005076 + label: Disease + name: Eruption of skin + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + disease: Contact dermatitis + disease_mesh: MESH:D003877 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB01047 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: positively correlated with + source: GO:0006954 + target: MESH:D003877 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D003877 + label: Disease + name: Contact dermatitis + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + disease: Seborrheic dermatitis + disease_mesh: MESH:D012628 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB010473 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: has phenotype + source: GO:0006954 + target: HP:0000989 + - key: manifestation of + source: HP:0000989 + target: MESH:D012628 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: HP:0000989 + label: PhenotypicFeature + name: Pruritus + - id: MESH:D012628 + label: Disease + name: Seborrheic dermatitis + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + disease: Lichen simplex chronicus + disease_mesh: MESH:D009450 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB010473 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: has phenotype + source: GO:0006954 + target: HP:0000989 + - key: manifestation of + source: HP:0000989 + target: MESH:D009450 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: HP:0000989 + label: PhenotypicFeature + name: Pruritus + - id: MESH:D009450 + label: Disease + name: Lichen simplex chronicus + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + disease: Atopic dermatitis + disease_mesh: MESH:D003876 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB010473 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: has phenotype + source: GO:0006954 + target: HP:0000989 + - key: has phenotype + source: GO:0006954 + target: HP:0000969 + - key: manifestation of + source: HP:0000989 + target: MESH:D003876 + - key: manifestation of + source: HP:0000969 + target: MESH:D003876 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: HP:0000989 + label: PhenotypicFeature + name: Pruritus + - id: HP:0000969 + label: PhenotypicFeature + name: Edema + - id: MESH:D003876 + label: Disease + name: Atopic dermatitis + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + disease: Bipolar disorder + disease_mesh: MESH:D001714 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: MESH:D001714 + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P4984 + - key: positively correlated with + source: UniProt:P4984 + target: HP:0000713 + - key: occurs in + source: HP:0000713 + target: MESH:D001714 + - key: positively regulates + source: MESH:D016651 + target: GO:0061534 + - key: negatively correlated with + source: GO:0061534 + target: MESH:D001714 + - key: negatively regulates + source: MESH:D016651 + target: GO:0061527 + - key: positively correlated with + source: GO:0061527 + target: MESH:D001714 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: MESH:D001714 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: UniProt:P4984 + label: Protein + name: Glycogen synthase kinase-3 beta + - id: HP:0000713 + label: PhenotypicFeature + name: Agitation + - id: GO:0061534 + label: BiologicalProcess + name: Gamma-aminobutyric acid secretion, neurotransmission + - id: GO:0061527 + label: BiologicalProcess + name: Dopamine secretion, neurotransmission + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: MESH:D001714 + label: Disease + name: Bipolar disorder + reference: + - https://pubmed.ncbi.nlm.nih.gov/23371914/ + - https://go.drugbank.com/drugs/DB14509 + - https://en.wikipedia.org/wiki/Lithium_(medication)#Bipolar_disorder +- directed: true + graph: + disease: Headache disorder + disease_mesh: MESH:D020773 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: GO:0019233 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: GO:0061535 + - key: positively correlated with + source: GO:0061535 + target: GO:0019233 + - key: positively correlated with + source: GO:0019233 + target: MESH:D020773 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: GO:0019233 + label: BiologicalProcess + name: Sensory perception of pain + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: GO:0061535 + label: BiologicalProcess + name: Glutamate secretion, neurotransmission + - id: MESH:D020773 + label: Disease + name: Headache disorder + reference: + - https://go.drugbank.com/drugs/DB14509 +- directed: true + graph: + disease: Pain + disease_mesh: MESH:D010146 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: GO:0019233 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: GO:0061535 + - key: positively correlated with + source: GO:0061535 + target: GO:0019233 + - key: positively correlated with + source: GO:0019233 + target: MESH:D010146 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: GO:0019233 + label: BiologicalProcess + name: Sensory perception of pain + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: GO:0061535 + label: BiologicalProcess + name: Glutamate secretion, neurotransmission + - id: MESH:D010146 + label: Disease + name: Pain + reference: + - https://go.drugbank.com/drugs/DB14509 +- comment: Lithium can cause side effects such as fever. + directed: true + graph: + disease: Fever + disease_mesh: MESH:D005334 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: causes + source: MESH:D016651 + target: MESH:D005334 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: MESH:D005334 + label: Disease + name: Fever + reference: + - https://en.wikipedia.org/wiki/Lithium_toxicity + - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164879/ +- directed: true + graph: + disease: Osteoarthritis + disease_mesh: MESH:D010003 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: GO:0019233 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: GO:0061535 + - key: positively correlated with + source: GO:0061535 + target: GO:0019233 + - key: positively correlated with + source: GO:0019233 + target: MESH:D010003 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: GO:0019233 + label: BiologicalProcess + name: Sensory perception of pain + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: GO:0061535 + label: BiologicalProcess + name: Glutamate secretion, neurotransmission + - id: MESH:D010003 + label: Disease + name: Osteoarthritis + reference: + - https://go.drugbank.com/drugs/DB14509 +- directed: true + graph: + disease: Juvenile rheumatoid arthritis + disease_mesh: MESH:D001171 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: GO:0019233 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: GO:0061535 + - key: positively correlated with + source: GO:0061535 + target: GO:0019233 + - key: positively correlated with + source: GO:0019233 + target: MESH:D001171 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: GO:0019233 + label: BiologicalProcess + name: Sensory perception of pain + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: GO:0061535 + label: BiologicalProcess + name: Glutamate secretion, neurotransmission + - id: MESH:D001171 + label: Disease + name: Juvenile rheumatoid arthritis + reference: + - https://go.drugbank.com/drugs/DB14509 +- directed: true + graph: + disease: Rheumatoid arthritis + disease_mesh: MESH:D001172 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: GO:0019233 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: GO:0061535 + - key: positively correlated with + source: GO:0061535 + target: GO:0019233 + - key: positively correlated with + source: GO:0019233 + target: MESH:D001172 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: GO:0019233 + label: BiologicalProcess + name: Sensory perception of pain + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: GO:0061535 + label: BiologicalProcess + name: Glutamate secretion, neurotransmission + - id: MESH:D001172 + label: Disease + name: Rheumatoid arthritis + reference: + - https://go.drugbank.com/drugs/DB14509 +- directed: true + graph: + disease: Dysmenorrhea + disease_mesh: MESH:D004412 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: GO:0019233 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: GO:0061535 + - key: positively correlated with + source: GO:0061535 + target: GO:0019233 + - key: positively correlated with + source: GO:0019233 + target: MESH:D004412 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: GO:0019233 + label: BiologicalProcess + name: Sensory perception of pain + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: GO:0061535 + label: BiologicalProcess + name: Glutamate secretion, neurotransmission + - id: MESH:D004412 + label: Disease + name: Dysmenorrhea + reference: + - https://go.drugbank.com/drugs/DB14509 +- directed: true + graph: + disease: Tear film insufficiency + disease_mesh: MESH:D015352 + drug: lifitegrast + drug_mesh: MESH:C575157 + drugbank: DB:DB11611 + links: + - key: decreases activity of + source: MESH:C575157 + target: UniProt:P20701 + - key: positively correlated with + source: UniProt:P20701 + target: GO:0042110 + - key: positively correlated with + source: UniProt:P20701 + target: GO:0042098 + - key: positively correlated with + source: GO:0042110 + target: GO:0006954 + - key: positively correlated with + source: GO:0042098 + target: GO:0006954 + - key: occurs in + source: GO:0006954 + target: MESH:D015352 + multigraph: true + nodes: + - id: MESH:C575157 + label: Drug + name: Lifitegrast + - id: UniProt:P20701 + label: Protein + name: Integrin alpha-L + - id: GO:0042098 + label: BiologicalProcess + name: T cell proliferation + - id: GO:0042110 + label: BiologicalProcess + name: T cell activation + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D015352 + label: Disease + name: Tear film insufficiency + reference: + - https://go.drugbank.com/drugs/DB11611 + - https://en.wikipedia.org/wiki/Lifitegrast +- directed: true + graph: + disease: Hemorrhagic disease of the newborn due to vitamin K deficiency + disease_mesh: MESH:D006475 + drug: menatetrenone + drug_mesh: MESH:C030814 + drugbank: DB:DB12148 + links: + - key: increases activity of + source: MESH:C030814 + target: UniProt:P38435 + - key: positively regulates + source: UniProt:P38435 + target: GO:0007596 + - key: negatively correlated with + source: GO:0007596 + target: MESH:D006475 + multigraph: true + nodes: + - id: MESH:C030814 + label: Drug + name: Menatetrenone + - id: UniProt:P38435 + label: Protein + name: Vitamin K-dependent gamma-carboxylase + - id: GO:0007596 + label: BiologicalProcess + name: Blood coagulation + - id: MESH:D006475 + label: Disease + name: Hemorrhagic disease of the newborn due to vitamin K deficiency + reference: + - https://en.wikipedia.org/wiki/Vitamin_K2#Mechanism_of_action From c4a5e98036a84879790d677637c35db53f86640c Mon Sep 17 00:00:00 2001 From: TanskaAnnna Date: Wed, 23 Jun 2021 12:43:37 +0000 Subject: [PATCH 2/2] Commit from GitHub Actions (Update Indications on Merge) --- indication_paths.json | 2616 +++++++++++++++++++++++++++++++++++++++++ indication_paths.yaml | 1612 +++++++++++++++++++++++++ submission.yaml | 1588 +------------------------ 3 files changed, 4229 insertions(+), 1587 deletions(-) diff --git a/indication_paths.json b/indication_paths.json index 2f5a5a40d..ba8bd8c7b 100644 --- a/indication_paths.json +++ b/indication_paths.json @@ -237172,5 +237172,2621 @@ "reference": [ "https://go.drugbank.com/drugs/DB13783" ] + }, + { + "directed": true, + "graph": { + "_id": "DB00041_MESH_D015470_1", + "disease": "Acute myeloid leukemia, disease", + "disease_mesh": "MESH:D015470", + "drug": "aldesleukin", + "drug_mesh": "MESH:C082598", + "drugbank": "DB:DB00041" + }, + "links": [ + { + "key": "increases activity of", + "source": "MESH:C082598", + "target": "UniProt:P14784" + }, + { + "key": "positively regulates", + "source": "UniProt:P14784", + "target": "GO:0038110" + }, + { + "key": "increases activity of", + "source": "MESH:C082598", + "target": "UniProt:P01589" + }, + { + "key": "positively regulates", + "source": "UniProt:P01589", + "target": "GO:0038110" + }, + { + "key": "positively regulates", + "source": "GO:0038110", + "target": "GO:0045065" + }, + { + "key": "positively regulates", + "source": "GO:0038110", + "target": "GO:0030101" + }, + { + "key": "treats", + "source": "GO:0045065", + "target": "MESH:D015470" + }, + { + "key": "treats", + "source": "GO:0030101", + "target": "MESH:D015470" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:C082598", + "label": "Drug", + "name": "Aldesleukin" + }, + { + "id": "UniProt:P14784", + "label": "Protein", + "name": "Interleukin-2 receptor subunit beta" + }, + { + "id": "UniProt:P01589", + "label": "Protein", + "name": "Interleukin-2 receptor subunit alpha" + }, + { + "id": "GO:0038110", + "label": "BiologicalProcess", + "name": "Interleukin-2-mediated signaling pathway" + }, + { + "id": "GO:0045065", + "label": "BiologicalProcess", + "name": "Cytotoxic T cell differentiation" + }, + { + "id": "GO:0030101", + "label": "BiologicalProcess", + "name": "Natural killer cell activation" + }, + { + "id": "MESH:D015470", + "label": "Disease", + "name": "Acute myeloid leukemia, disease" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB00041" + ] + }, + { + "directed": true, + "graph": { + "_id": "DB00346_MESH_D011470_1", + "disease": "Benign prostatic hyperplasia", + "disease_mesh": "MESH:D011470", + "drug": "alfuzosin", + "drug_mesh": "MESH:C047638", + "drugbank": "DB:DB00346" + }, + "links": [ + { + "key": "decreases activity of", + "source": "MESH:C047638", + "target": "UniProt:P35348" + }, + { + "key": "decreases activity of", + "source": "MESH:C047638", + "target": "UniProt:P35368" + }, + { + "key": "decreases activity of", + "source": "MESH:C047638", + "target": "UniProt:P25100" + }, + { + "key": "positively regulates", + "source": "UniProt:P35348", + "target": "GO:0014832" + }, + { + "key": "positively regulates", + "source": "UniProt:P35368", + "target": "GO:0014832" + }, + { + "key": "positively regulates", + "source": "UniProt:P25100", + "target": "GO:0014832" + }, + { + "key": "positively correlated with", + "source": "GO:0014832", + "target": "HP:0100515" + }, + { + "key": "manifestation of", + "source": "HP:0100515", + "target": "MESH:D011470" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:C047638", + "label": "Drug", + "name": "Alfuzosin" + }, + { + "id": "UniProt:P35348", + "label": "Protein", + "name": "Alpha-1A adrenergic receptor" + }, + { + "id": "UniProt:P35368", + "label": "Protein", + "name": "Alpha-1B adrenergic receptor" + }, + { + "id": "UniProt:P25100", + "label": "Protein", + "name": "Alpha-1D adrenergic receptor" + }, + { + "id": "GO:0014832", + "label": "BiologicalProcess", + "name": "Urinary bladder smooth muscle contraction" + }, + { + "id": "HP:0100515", + "label": "PhenotypicFeature", + "name": "Pollakisuria" + }, + { + "id": "MESH:D011470", + "label": "Disease", + "name": "Benign prostatic hyperplasia" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB00346" + ] + }, + { + "directed": true, + "graph": { + "_id": "DB00637_MESH_D012912_1", + "disease": "Sneezing", + "disease_mesh": "MESH:D012912", + "drug": "astemizole", + "drug_mesh": "MESH:D016589", + "drugbank": "DB:DB00637" + }, + "links": [ + { + "key": "decreases activity of", + "source": "MESH:D016589", + "target": "UniProt:P35367" + }, + { + "key": "participates in", + "source": "UniProt:P35367", + "target": "GO:0051381" + }, + { + "key": "positively regulates", + "source": "GO:0051381", + "target": "GO:0023041" + }, + { + "key": "located in", + "source": "GO:0023041", + "target": "UBERON:0000004" + }, + { + "key": "affected by", + "source": "UBERON:0000004", + "target": "UBERON:0001645" + }, + { + "key": "contributes to", + "source": "UBERON:0001645", + "target": "MESH:D012912" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:D016589", + "label": "Drug", + "name": "Astemizole" + }, + { + "id": "UniProt:P35367", + "label": "Protein", + "name": "Histamine H1 receptor" + }, + { + "id": "GO:0051381", + "label": "MolecularActivity", + "name": "Histamine binding" + }, + { + "id": "GO:0023041", + "label": "BiologicalProcess", + "name": "Neuronal signal transduction" + }, + { + "id": "UBERON:0000004", + "label": "GrossAnatomicalStructure", + "name": "Nose" + }, + { + "id": "UBERON:0001645", + "label": "GrossAnatomicalStructure", + "name": "Trigeminal nerve" + }, + { + "id": "MESH:D012912", + "label": "Disease", + "name": "Sneezing" + } + ], + "reference": [ + 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"MESH:D016651", + "label": "Drug", + "name": "Lithium carbonate" + }, + { + "id": "UniProt:P29218", + "label": "Protein", + "name": "Inositol monophosphatase 1" + }, + { + "id": "GO:0046855", + "label": "BiologicalProcess", + "name": "Inositol phosphate dephosphorylation" + }, + { + "id": "MESH:D007294", + "label": "BiologicalProcess", + "name": "Inositol" + }, + { + "id": "GO:0043647", + "label": "BiologicalProcess", + "name": "Inositol phosphate metabolic process" + }, + { + "id": "GO:0014047", + "label": "BiologicalProcess", + "name": "Glutamate secretion" + }, + { + "id": "GO:0019233", + "label": "BiologicalProcess", + "name": "Sensory perception of pain" + }, + { + "id": "GO:0004972", + "label": "MolecularActivity", + "name": "NMDA glutamate receptor activity" + }, + { + "id": "MESH:D018698", + "label": "ChemicalSubstance", + "name": "Glutamic Acid" + }, + { + "id": "GO:0061535", + "label": "BiologicalProcess", + "name": "Glutamate secretion, neurotransmission" + }, + { + "id": "MESH:D001172", + "label": "Disease", + "name": "Rheumatoid arthritis" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB14509" + ] + }, + { + "directed": true, + "graph": { + "_id": "DB01356_MESH_D004412_1", + "disease": "Dysmenorrhea", + "disease_mesh": "MESH:D004412", + "drug": "lithium carbonate", + "drug_mesh": "MESH:D016651", + "drugbank": "DB:DB01356" + }, + "links": [ + { + "key": "decreases activity of", + "source": "MESH:D016651", + "target": "UniProt:P29218" + }, + { + "key": "positively regulates", + "source": "UniProt:P29218", + "target": "GO:0046855" + }, + { + "key": "increases abundance of", + "source": "GO:0046855", + "target": "MESH:D007294" + }, + { + "key": "positively regulates", + "source": "MESH:D007294", + "target": "GO:0043647" + }, + { + "key": "positively regulates", + "source": "GO:0043647", + "target": "GO:0014047" + }, + { + "key": "positively correlated with", + "source": "GO:0014047", + "target": "GO:0019233" + }, + { + "key": "negatively regulates", + "source": "MESH:D016651", + "target": "GO:0004972" + }, + { + "key": "positively correlated with", + "source": "GO:0004972", + "target": "MESH:D018698" + }, + { + "key": "positively correlated with", + "source": "MESH:D018698", + "target": "GO:0061535" + }, + { + "key": "positively correlated with", + "source": "GO:0061535", + "target": "GO:0019233" + }, + { + "key": "positively correlated with", + "source": "GO:0019233", + "target": "MESH:D004412" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:D016651", + "label": "Drug", + "name": "Lithium carbonate" + }, + { + "id": "UniProt:P29218", + "label": "Protein", + "name": "Inositol monophosphatase 1" + }, + { + "id": "GO:0046855", + "label": "BiologicalProcess", + "name": "Inositol phosphate dephosphorylation" + }, + { + "id": "MESH:D007294", + "label": "BiologicalProcess", + "name": "Inositol" + }, + { + "id": "GO:0043647", + "label": "BiologicalProcess", + "name": "Inositol phosphate metabolic process" + }, + { + "id": "GO:0014047", + "label": "BiologicalProcess", + "name": "Glutamate secretion" + }, + { + "id": "GO:0019233", + "label": "BiologicalProcess", + "name": "Sensory perception of pain" + }, + { + "id": "GO:0004972", + "label": "MolecularActivity", + "name": "NMDA glutamate receptor activity" + }, + { + "id": "MESH:D018698", + "label": "ChemicalSubstance", + "name": "Glutamic Acid" + }, + { + "id": "GO:0061535", + "label": "BiologicalProcess", + "name": "Glutamate secretion, neurotransmission" + }, + { + "id": "MESH:D004412", + "label": "Disease", + "name": "Dysmenorrhea" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB14509" + ] + }, + { + "directed": true, + "graph": { + "_id": "DB11611_MESH_D015352_1", + "disease": "Tear film insufficiency", + "disease_mesh": "MESH:D015352", + "drug": "lifitegrast", + "drug_mesh": "MESH:C575157", + "drugbank": "DB:DB11611" + }, + "links": [ + { + "key": "decreases activity of", + "source": "MESH:C575157", + "target": "UniProt:P20701" + }, + { + "key": "positively correlated with", + "source": "UniProt:P20701", + "target": "GO:0042110" + }, + { + "key": "positively correlated with", + "source": "UniProt:P20701", + "target": "GO:0042098" + }, + { + "key": "positively correlated with", + "source": "GO:0042110", + "target": "GO:0006954" + }, + { + "key": "positively correlated with", + "source": "GO:0042098", + "target": "GO:0006954" + }, + { + "key": "occurs in", + "source": "GO:0006954", + "target": "MESH:D015352" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:C575157", + "label": "Drug", + "name": "Lifitegrast" + }, + { + "id": "UniProt:P20701", + "label": "Protein", + "name": "Integrin alpha-L" + }, + { + "id": "GO:0042098", + "label": "BiologicalProcess", + "name": "T cell proliferation" + }, + { + "id": "GO:0042110", + "label": "BiologicalProcess", + "name": "T cell activation" + }, + { + "id": "GO:0006954", + "label": "BiologicalProcess", + "name": "Inflammatory response" + }, + { + "id": "MESH:D015352", + "label": "Disease", + "name": "Tear film insufficiency" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB11611", + "https://en.wikipedia.org/wiki/Lifitegrast" + ] + }, + { + "directed": true, + "graph": { + "_id": "DB12148_MESH_D006475_1", + "disease": "Hemorrhagic disease of the newborn due to vitamin K deficiency", + "disease_mesh": "MESH:D006475", + "drug": "menatetrenone", + "drug_mesh": "MESH:C030814", + "drugbank": "DB:DB12148" + }, + "links": [ + { + "key": "increases activity of", + "source": "MESH:C030814", + "target": "UniProt:P38435" + }, + { + "key": "positively regulates", + "source": "UniProt:P38435", + "target": "GO:0007596" + }, + { + "key": "negatively correlated with", + "source": "GO:0007596", + "target": "MESH:D006475" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:C030814", + "label": "Drug", + "name": "Menatetrenone" + }, + { + "id": "UniProt:P38435", + "label": "Protein", + "name": "Vitamin K-dependent gamma-carboxylase" + }, + { + "id": "GO:0007596", + "label": "BiologicalProcess", + "name": "Blood coagulation" + }, + { + "id": "MESH:D006475", + "label": "Disease", + "name": "Hemorrhagic disease of the newborn due to vitamin K deficiency" + } + ], + "reference": [ + "https://en.wikipedia.org/wiki/Vitamin_K2#Mechanism_of_action" + ] } ] \ No newline at end of file diff --git a/indication_paths.yaml b/indication_paths.yaml index 0cbdcb1c1..c5d21cc74 100644 --- a/indication_paths.yaml +++ b/indication_paths.yaml @@ -149093,3 +149093,1615 @@ name: Rheumatism reference: - https://go.drugbank.com/drugs/DB13783 +- directed: true + graph: + _id: DB00041_MESH_D015470_1 + disease: Acute myeloid leukemia, disease + disease_mesh: MESH:D015470 + drug: aldesleukin + drug_mesh: MESH:C082598 + drugbank: DB:DB00041 + links: + - key: increases activity of + source: MESH:C082598 + target: UniProt:P14784 + - key: positively regulates + source: UniProt:P14784 + target: GO:0038110 + - key: increases activity of + source: MESH:C082598 + target: UniProt:P01589 + - key: positively regulates + source: UniProt:P01589 + target: GO:0038110 + - key: positively regulates + source: GO:0038110 + target: GO:0045065 + - key: positively regulates + source: GO:0038110 + target: GO:0030101 + - key: treats + source: GO:0045065 + target: MESH:D015470 + - key: treats + source: GO:0030101 + target: MESH:D015470 + multigraph: true + nodes: + - id: MESH:C082598 + label: Drug + name: Aldesleukin + - id: UniProt:P14784 + label: Protein + name: Interleukin-2 receptor subunit beta + - id: UniProt:P01589 + label: Protein + name: Interleukin-2 receptor subunit alpha + - id: GO:0038110 + label: BiologicalProcess + name: Interleukin-2-mediated signaling pathway + - id: GO:0045065 + label: BiologicalProcess + name: Cytotoxic T cell differentiation + - id: GO:0030101 + label: BiologicalProcess + name: Natural killer cell activation + - id: MESH:D015470 + label: Disease + name: Acute myeloid leukemia, disease + reference: + - https://go.drugbank.com/drugs/DB00041 +- directed: true + graph: + _id: DB00346_MESH_D011470_1 + disease: Benign prostatic hyperplasia + disease_mesh: MESH:D011470 + drug: alfuzosin + drug_mesh: MESH:C047638 + drugbank: DB:DB00346 + links: + - key: decreases activity of + source: MESH:C047638 + target: UniProt:P35348 + - key: decreases activity of + source: MESH:C047638 + target: UniProt:P35368 + - key: decreases activity of + source: MESH:C047638 + target: UniProt:P25100 + - key: positively regulates + source: UniProt:P35348 + target: GO:0014832 + - key: positively regulates + source: UniProt:P35368 + target: GO:0014832 + - key: positively regulates + source: UniProt:P25100 + target: GO:0014832 + - key: positively correlated with + source: GO:0014832 + target: HP:0100515 + - key: manifestation of + source: HP:0100515 + target: MESH:D011470 + multigraph: true + nodes: + - id: MESH:C047638 + label: Drug + name: Alfuzosin + - id: UniProt:P35348 + label: Protein + name: Alpha-1A adrenergic receptor + - id: UniProt:P35368 + label: Protein + name: Alpha-1B adrenergic receptor + - id: UniProt:P25100 + label: Protein + name: Alpha-1D adrenergic receptor + - id: GO:0014832 + label: BiologicalProcess + name: Urinary bladder smooth muscle contraction + - id: HP:0100515 + label: PhenotypicFeature + name: Pollakisuria + - id: MESH:D011470 + label: Disease + name: Benign prostatic hyperplasia + reference: + - https://go.drugbank.com/drugs/DB00346 +- directed: true + graph: + _id: DB00637_MESH_D012912_1 + disease: Sneezing + disease_mesh: MESH:D012912 + drug: astemizole + drug_mesh: MESH:D016589 + drugbank: DB:DB00637 + links: + - key: decreases activity of + source: MESH:D016589 + target: UniProt:P35367 + - key: participates in + source: UniProt:P35367 + target: GO:0051381 + - key: positively regulates + source: GO:0051381 + target: GO:0023041 + - key: located in + source: GO:0023041 + target: UBERON:0000004 + - key: affected by + source: UBERON:0000004 + target: UBERON:0001645 + - key: contributes to + source: UBERON:0001645 + target: MESH:D012912 + multigraph: true + nodes: + - id: MESH:D016589 + label: Drug + name: Astemizole + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: GO:0051381 + label: MolecularActivity + name: Histamine binding + - id: GO:0023041 + label: BiologicalProcess + name: Neuronal signal transduction + - id: UBERON:0000004 + label: GrossAnatomicalStructure + name: Nose + - id: UBERON:0001645 + label: GrossAnatomicalStructure + name: Trigeminal nerve + - id: MESH:D012912 + label: Disease + name: Sneezing + reference: + - https://go.drugbank.com/drugs/DB00637 + - https://en.wikipedia.org/wiki/Sneeze +- directed: true + graph: + _id: DB00637_MESH_D003233_1 + disease: Allergic conjunctivitis + disease_mesh: MESH:D003233 + drug: astemizole + drug_mesh: MESH:D016589 + drugbank: DB:DB00637 + links: + - key: negatively regulates + source: MESH:D016589 + target: UniProt:P35367 + - key: positively regulates + source: UniProt:P35367 + target: GO:0004969 + - key: participates in + source: GO:0004969 + target: GO:0071420 + - key: positively correlated with + source: GO:0071420 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D003233 + multigraph: true + nodes: + - id: MESH:D016589 + label: Drug + name: Astemizole + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: GO:0004969 + label: MolecularActivity + name: Histamine receptor activity + - id: GO:0071420 + label: BiologicalProcess + name: Cellular response to histamine + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D003233 + label: Disease + name: Allergic conjunctivitis + reference: + - https://go.drugbank.com/drugs/DB00637 +- directed: true + graph: + _id: DB00637_MESH_D000080223_1 + disease: Chronic idiopathic urticaria + disease_mesh: MESH:D000080223 + drug: Astemizole + drug_mesh: MESH:D016589 + drugbank: DB:DB00637 + links: + - key: decreases activity of + source: MESH:D016589 + target: UniProt:P35367 + - key: positively regulates + source: UniProt:P35367 + target: GO:0004969 + - key: participates in + source: GO:0004969 + target: GO:0071420 + - key: positively correlated with + source: GO:0071420 + target: GO:0006954 + - key: positively correlated with + source: GO:0071420 + target: GO:0043117 + - key: positively correlated with + source: GO:0071420 + target: HP:0000969 + - key: manifestation of + source: HP:0000969 + target: MESH:D000080223 + - key: manifestation of + source: GO:0043117 + target: MESH:D000080223 + - key: causes + source: GO:0006954 + target: MESH:D000080223 + multigraph: true + nodes: + - id: MESH:D016589 + label: Drug + name: Astemizole + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: GO:0004969 + label: MolecularActivity + name: Histamine receptor activity + - id: GO:0071420 + label: BiologicalProcess + name: Cellular response to histamine + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: GO:0043117 + label: BiologicalProcess + name: Positive regulation of vascular permeability + - id: HP:0000969 + label: PhenotypicFeature + name: Edema + - id: MESH:D000080223 + label: Disease + name: Chronic idiopathic urticaria + reference: + - https://go.drugbank.com/drugs/DB00637 +- directed: true + graph: + _id: DB00637_MESH_D065631_1 + disease: Allergic rhinitis + disease_mesh: MESH:D065631 + drug: Astemizole + drug_mesh: MESH:D016589 + drugbank: DB:DB00637 + links: + - key: decreases activity of + source: MESH:D016589 + target: UniProt:P35367 + - key: positively regulates + source: UniProt:P35367 + target: GO:0004969 + - key: participates in + source: GO:0004969 + target: GO:0071420 + - key: positively correlated with + source: GO:0071420 + target: GO:0006954 + - key: has phenotype + source: GO:0006954 + target: HP:0031417 + - key: manifestation of + source: HP:0031417 + target: MESH:D065631 + multigraph: true + nodes: + - id: MESH:D016589 + label: Drug + name: Astemizole + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: GO:0004969 + label: MolecularActivity + name: Histamine receptor activity + - id: GO:0071420 + label: BiologicalProcess + name: Cellular response to histamine + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: HP:0031417 + label: PhenotypicFeature + name: Rhinorrhea + - id: MESH:D065631 + label: Disease + name: Allergic rhinitis + reference: + - https://go.drugbank.com/drugs/DB00637 +- directed: true + graph: + _id: DB01047_MESH_D016410_1 + disease: Primary cutaneous T-cell lymphoma + disease_mesh: MESH:D016410 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB01047 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: has phenotype + source: GO:0006954 + target: HP:0000989 + - key: has phenotype + source: GO:0006954 + target: HP:0000988 + - key: manifestation of + source: HP:0000989 + target: MESH:D016410 + - key: manifestation of + source: HP:0000988 + target: MESH:D016410 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: HP:0000989 + label: PhenotypicFeature + name: Pruritus + - id: HP:0000988 + label: PhenotypicFeature + name: Skin rash + - id: MESH:D016410 + label: Disease + name: Primary cutaneous T-cell lymphoma + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + _id: DB01047_MESH_D008179_1 + disease: Discoid lupus erythematosus + disease_mesh: MESH:D008179 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB01047 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: positively correlated with + source: GO:0006954 + target: MESH:D008179 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D008179 + label: Disease + name: Discoid lupus erythematosus + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + _id: DB01047_MESH_D011538_1 + disease: Pruritus ani + disease_mesh: MESH:D011538 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB01047 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: has phenotype + source: GO:0006954 + target: HP:0000989 + - key: manifestation of + source: HP:0000989 + target: MESH:D011538 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: HP:0000989 + label: PhenotypicFeature + name: Pruritus + - id: MESH:D011538 + label: Disease + name: Pruritus ani + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + _id: DB01047_MESH_D016460_1 + disease: Granuloma annulare + disease_mesh: MESH:D016460 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB01047 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: positively correlated with + source: GO:0006954 + target: MESH:D016460 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D016460 + label: Disease + name: Granuloma annulare + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + _id: DB01047_MESH_D005076_1 + disease: Eruption of skin + disease_mesh: MESH:D005076 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB01047 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: positively correlated with + source: GO:0006954 + target: MESH:D005076 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D005076 + label: Disease + name: Eruption of skin + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + _id: DB01047_MESH_D003877_1 + disease: Contact dermatitis + disease_mesh: MESH:D003877 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB01047 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: positively correlated with + source: GO:0006954 + target: MESH:D003877 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D003877 + label: Disease + name: Contact dermatitis + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + _id: DB010473_MESH_D012628_1 + disease: Seborrheic dermatitis + disease_mesh: MESH:D012628 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB010473 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: has phenotype + source: GO:0006954 + target: HP:0000989 + - key: manifestation of + source: HP:0000989 + target: MESH:D012628 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: HP:0000989 + label: PhenotypicFeature + name: Pruritus + - id: MESH:D012628 + label: Disease + name: Seborrheic dermatitis + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + _id: DB010473_MESH_D009450_1 + disease: Lichen simplex chronicus + disease_mesh: MESH:D009450 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB010473 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: has phenotype + source: GO:0006954 + target: HP:0000989 + - key: manifestation of + source: HP:0000989 + target: MESH:D009450 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: HP:0000989 + label: PhenotypicFeature + name: Pruritus + - id: MESH:D009450 + label: Disease + name: Lichen simplex chronicus + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + _id: DB010473_MESH_D003876_1 + disease: Atopic dermatitis + disease_mesh: MESH:D003876 + drug: fluocinonide + drug_mesh: MESH:D005447 + drugbank: DB:DB010473 + links: + - key: increases activity of + source: MESH:D005447 + target: UniProt:P04150 + - key: increases activity of + source: UniProt:P04150 + target: UniProt:P04083 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P47712 + - key: decreases activity of + source: UniProt:P04083 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P47712 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: has phenotype + source: GO:0006954 + target: HP:0000989 + - key: has phenotype + source: GO:0006954 + target: HP:0000969 + - key: manifestation of + source: HP:0000989 + target: MESH:D003876 + - key: manifestation of + source: HP:0000969 + target: MESH:D003876 + multigraph: true + nodes: + - id: MESH:D005447 + label: Drug + name: Fluocinonide + - id: UniProt:P04150 + label: Protein + name: Glucocorticoid receptor + - id: UniProt:P04083 + label: Protein + name: Annexin A1 + - id: UniProt:P47712 + label: Protein + name: Cytosolic phospholipase A2 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: HP:0000989 + label: PhenotypicFeature + name: Pruritus + - id: HP:0000969 + label: PhenotypicFeature + name: Edema + - id: MESH:D003876 + label: Disease + name: Atopic dermatitis + reference: + - https://go.drugbank.com/drugs/DB01047 +- directed: true + graph: + _id: DB01356_MESH_D001714_1 + disease: Bipolar disorder + disease_mesh: MESH:D001714 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: MESH:D001714 + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P4984 + - key: positively correlated with + source: UniProt:P4984 + target: HP:0000713 + - key: occurs in + source: HP:0000713 + target: MESH:D001714 + - key: positively regulates + source: MESH:D016651 + target: GO:0061534 + - key: negatively correlated with + source: GO:0061534 + target: MESH:D001714 + - key: negatively regulates + source: MESH:D016651 + target: GO:0061527 + - key: positively correlated with + source: GO:0061527 + target: MESH:D001714 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: MESH:D001714 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: UniProt:P4984 + label: Protein + name: Glycogen synthase kinase-3 beta + - id: HP:0000713 + label: PhenotypicFeature + name: Agitation + - id: GO:0061534 + label: BiologicalProcess + name: Gamma-aminobutyric acid secretion, neurotransmission + - id: GO:0061527 + label: BiologicalProcess + name: Dopamine secretion, neurotransmission + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: MESH:D001714 + label: Disease + name: Bipolar disorder + reference: + - https://pubmed.ncbi.nlm.nih.gov/23371914/ + - https://go.drugbank.com/drugs/DB14509 + - https://en.wikipedia.org/wiki/Lithium_(medication)#Bipolar_disorder +- directed: true + graph: + _id: DB01356_MESH_D020773_1 + disease: Headache disorder + disease_mesh: MESH:D020773 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: GO:0019233 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: GO:0061535 + - key: positively correlated with + source: GO:0061535 + target: GO:0019233 + - key: positively correlated with + source: GO:0019233 + target: MESH:D020773 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: GO:0019233 + label: BiologicalProcess + name: Sensory perception of pain + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: GO:0061535 + label: BiologicalProcess + name: Glutamate secretion, neurotransmission + - id: MESH:D020773 + label: Disease + name: Headache disorder + reference: + - https://go.drugbank.com/drugs/DB14509 +- directed: true + graph: + _id: DB01356_MESH_D010146_1 + disease: Pain + disease_mesh: MESH:D010146 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: GO:0019233 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: GO:0061535 + - key: positively correlated with + source: GO:0061535 + target: GO:0019233 + - key: positively correlated with + source: GO:0019233 + target: MESH:D010146 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: GO:0019233 + label: BiologicalProcess + name: Sensory perception of pain + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: GO:0061535 + label: BiologicalProcess + name: Glutamate secretion, neurotransmission + - id: MESH:D010146 + label: Disease + name: Pain + reference: + - https://go.drugbank.com/drugs/DB14509 +- comment: Lithium can cause side effects such as fever. + directed: true + graph: + _id: DB01356_MESH_D005334_1 + disease: Fever + disease_mesh: MESH:D005334 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: causes + source: MESH:D016651 + target: MESH:D005334 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: MESH:D005334 + label: Disease + name: Fever + reference: + - https://en.wikipedia.org/wiki/Lithium_toxicity + - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164879/ +- directed: true + graph: + _id: DB01356_MESH_D010003_1 + disease: Osteoarthritis + disease_mesh: MESH:D010003 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: GO:0019233 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: GO:0061535 + - key: positively correlated with + source: GO:0061535 + target: GO:0019233 + - key: positively correlated with + source: GO:0019233 + target: MESH:D010003 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: GO:0019233 + label: BiologicalProcess + name: Sensory perception of pain + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: GO:0061535 + label: BiologicalProcess + name: Glutamate secretion, neurotransmission + - id: MESH:D010003 + label: Disease + name: Osteoarthritis + reference: + - https://go.drugbank.com/drugs/DB14509 +- directed: true + graph: + _id: DB01356_MESH_D001171_1 + disease: Juvenile rheumatoid arthritis + disease_mesh: MESH:D001171 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: GO:0019233 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: GO:0061535 + - key: positively correlated with + source: GO:0061535 + target: GO:0019233 + - key: positively correlated with + source: GO:0019233 + target: MESH:D001171 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: GO:0019233 + label: BiologicalProcess + name: Sensory perception of pain + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: GO:0061535 + label: BiologicalProcess + name: Glutamate secretion, neurotransmission + - id: MESH:D001171 + label: Disease + name: Juvenile rheumatoid arthritis + reference: + - https://go.drugbank.com/drugs/DB14509 +- directed: true + graph: + _id: DB01356_MESH_D001172_1 + disease: Rheumatoid arthritis + disease_mesh: MESH:D001172 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: GO:0019233 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: GO:0061535 + - key: positively correlated with + source: GO:0061535 + target: GO:0019233 + - key: positively correlated with + source: GO:0019233 + target: MESH:D001172 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: GO:0019233 + label: BiologicalProcess + name: Sensory perception of pain + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: GO:0061535 + label: BiologicalProcess + name: Glutamate secretion, neurotransmission + - id: MESH:D001172 + label: Disease + name: Rheumatoid arthritis + reference: + - https://go.drugbank.com/drugs/DB14509 +- directed: true + graph: + _id: DB01356_MESH_D004412_1 + disease: Dysmenorrhea + disease_mesh: MESH:D004412 + drug: lithium carbonate + drug_mesh: MESH:D016651 + drugbank: DB:DB01356 + links: + - key: decreases activity of + source: MESH:D016651 + target: UniProt:P29218 + - key: positively regulates + source: UniProt:P29218 + target: GO:0046855 + - key: increases abundance of + source: GO:0046855 + target: MESH:D007294 + - key: positively regulates + source: MESH:D007294 + target: GO:0043647 + - key: positively regulates + source: GO:0043647 + target: GO:0014047 + - key: positively correlated with + source: GO:0014047 + target: GO:0019233 + - key: negatively regulates + source: MESH:D016651 + target: GO:0004972 + - key: positively correlated with + source: GO:0004972 + target: MESH:D018698 + - key: positively correlated with + source: MESH:D018698 + target: GO:0061535 + - key: positively correlated with + source: GO:0061535 + target: GO:0019233 + - key: positively correlated with + source: GO:0019233 + target: MESH:D004412 + multigraph: true + nodes: + - id: MESH:D016651 + label: Drug + name: Lithium carbonate + - id: UniProt:P29218 + label: Protein + name: Inositol monophosphatase 1 + - id: GO:0046855 + label: BiologicalProcess + name: Inositol phosphate dephosphorylation + - id: MESH:D007294 + label: BiologicalProcess + name: Inositol + - id: GO:0043647 + label: BiologicalProcess + name: Inositol phosphate metabolic process + - id: GO:0014047 + label: BiologicalProcess + name: Glutamate secretion + - id: GO:0019233 + label: BiologicalProcess + name: Sensory perception of pain + - id: GO:0004972 + label: MolecularActivity + name: NMDA glutamate receptor activity + - id: MESH:D018698 + label: ChemicalSubstance + name: Glutamic Acid + - id: GO:0061535 + label: BiologicalProcess + name: Glutamate secretion, neurotransmission + - id: MESH:D004412 + label: Disease + name: Dysmenorrhea + reference: + - https://go.drugbank.com/drugs/DB14509 +- directed: true + graph: + _id: DB11611_MESH_D015352_1 + disease: Tear film insufficiency + disease_mesh: MESH:D015352 + drug: lifitegrast + drug_mesh: MESH:C575157 + drugbank: DB:DB11611 + links: + - key: decreases activity of + source: MESH:C575157 + target: UniProt:P20701 + - key: positively correlated with + source: UniProt:P20701 + target: GO:0042110 + - key: positively correlated with + source: UniProt:P20701 + target: GO:0042098 + - key: positively correlated with + source: GO:0042110 + target: GO:0006954 + - key: positively correlated with + source: GO:0042098 + target: GO:0006954 + - key: occurs in + source: GO:0006954 + target: MESH:D015352 + multigraph: true + nodes: + - id: MESH:C575157 + label: Drug + name: Lifitegrast + - id: UniProt:P20701 + label: Protein + name: Integrin alpha-L + - id: GO:0042098 + label: BiologicalProcess + name: T cell proliferation + - id: GO:0042110 + label: BiologicalProcess + name: T cell activation + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D015352 + label: Disease + name: Tear film insufficiency + reference: + - https://go.drugbank.com/drugs/DB11611 + - https://en.wikipedia.org/wiki/Lifitegrast +- directed: true + graph: + _id: DB12148_MESH_D006475_1 + disease: Hemorrhagic disease of the newborn due to vitamin K deficiency + disease_mesh: MESH:D006475 + drug: menatetrenone + drug_mesh: MESH:C030814 + drugbank: DB:DB12148 + links: + - key: increases activity of + source: MESH:C030814 + target: UniProt:P38435 + - key: positively regulates + source: UniProt:P38435 + target: GO:0007596 + - key: negatively correlated with + source: GO:0007596 + target: MESH:D006475 + multigraph: true + nodes: + - id: MESH:C030814 + label: Drug + name: Menatetrenone + - id: UniProt:P38435 + label: Protein + name: Vitamin K-dependent gamma-carboxylase + - id: GO:0007596 + label: BiologicalProcess + name: Blood coagulation + - id: MESH:D006475 + label: Disease + name: Hemorrhagic disease of the newborn due to vitamin K deficiency + reference: + - https://en.wikipedia.org/wiki/Vitamin_K2#Mechanism_of_action diff --git a/submission.yaml b/submission.yaml index fa28f9b9d..8b1378917 100644 --- a/submission.yaml +++ b/submission.yaml @@ -1,1587 +1 @@ -- directed: true - graph: - disease: Acute myeloid leukemia, disease - disease_mesh: MESH:D015470 - drug: aldesleukin - drug_mesh: MESH:C082598 - drugbank: DB:DB00041 - links: - - key: increases activity of - source: MESH:C082598 - target: UniProt:P14784 - - key: positively regulates - source: UniProt:P14784 - target: GO:0038110 - - key: increases activity of - source: MESH:C082598 - target: UniProt:P01589 - - key: positively regulates - source: UniProt:P01589 - target: GO:0038110 - - key: positively regulates - source: GO:0038110 - target: GO:0045065 - - key: positively regulates - source: GO:0038110 - target: GO:0030101 - - key: treats - source: GO:0045065 - target: MESH:D015470 - - key: treats - source: GO:0030101 - target: MESH:D015470 - multigraph: true - nodes: - - id: MESH:C082598 - label: Drug - name: Aldesleukin - - id: UniProt:P14784 - label: Protein - name: Interleukin-2 receptor subunit beta - - id: UniProt:P01589 - label: Protein - name: Interleukin-2 receptor subunit alpha - - id: GO:0038110 - label: BiologicalProcess - name: Interleukin-2-mediated signaling pathway - - id: GO:0045065 - label: BiologicalProcess - name: Cytotoxic T cell differentiation - - id: GO:0030101 - label: BiologicalProcess - name: Natural killer cell activation - - id: MESH:D015470 - label: Disease - name: Acute myeloid leukemia, disease - reference: - - https://go.drugbank.com/drugs/DB00041 -- directed: true - graph: - disease: Benign prostatic hyperplasia - disease_mesh: MESH:D011470 - drug: alfuzosin - drug_mesh: MESH:C047638 - drugbank: DB:DB00346 - links: - - key: decreases activity of - source: MESH:C047638 - target: UniProt:P35348 - - key: decreases activity of - source: MESH:C047638 - target: UniProt:P35368 - - key: decreases activity of - source: MESH:C047638 - target: UniProt:P25100 - - key: positively regulates - source: UniProt:P35348 - target: GO:0014832 - - key: positively regulates - source: UniProt:P35368 - target: GO:0014832 - - key: positively regulates - source: UniProt:P25100 - target: GO:0014832 - - key: positively correlated with - source: GO:0014832 - target: HP:0100515 - - key: manifestation of - source: HP:0100515 - target: MESH:D011470 - multigraph: true - nodes: - - id: MESH:C047638 - label: Drug - name: Alfuzosin - - id: UniProt:P35348 - label: Protein - name: Alpha-1A adrenergic receptor - - id: UniProt:P35368 - label: Protein - name: Alpha-1B adrenergic receptor - - id: UniProt:P25100 - label: Protein - name: Alpha-1D adrenergic receptor - - id: GO:0014832 - label: BiologicalProcess - name: Urinary bladder smooth muscle contraction - - id: HP:0100515 - label: PhenotypicFeature - name: Pollakisuria - - id: MESH:D011470 - label: Disease - name: Benign prostatic hyperplasia - reference: - - https://go.drugbank.com/drugs/DB00346 -- directed: true - graph: - disease: Sneezing - disease_mesh: MESH:D012912 - drug: astemizole - drug_mesh: MESH:D016589 - drugbank: DB:DB00637 - links: - - key: decreases activity of - source: MESH:D016589 - target: UniProt:P35367 - - key: participates in - source: UniProt:P35367 - target: GO:0051381 - - key: positively regulates - source: GO:0051381 - target: GO:0023041 - - key: located in - source: GO:0023041 - target: UBERON:0000004 - - key: affected by - source: UBERON:0000004 - target: UBERON:0001645 - - key: contributes to - source: UBERON:0001645 - target: MESH:D012912 - multigraph: true - nodes: - - id: MESH:D016589 - label: Drug - name: Astemizole - - id: UniProt:P35367 - label: Protein - name: Histamine H1 receptor - - id: GO:0051381 - label: MolecularActivity - name: Histamine binding - - id: GO:0023041 - label: BiologicalProcess - name: Neuronal signal transduction - - id: UBERON:0000004 - label: GrossAnatomicalStructure - name: Nose - - id: UBERON:0001645 - label: GrossAnatomicalStructure - name: Trigeminal nerve - - id: MESH:D012912 - label: Disease - name: Sneezing - reference: - - https://go.drugbank.com/drugs/DB00637 - - https://en.wikipedia.org/wiki/Sneeze -- directed: true - graph: - disease: Allergic conjunctivitis - disease_mesh: MESH:D003233 - drug: astemizole - drug_mesh: MESH:D016589 - drugbank: DB:DB00637 - links: - - key: negatively regulates - source: MESH:D016589 - target: UniProt:P35367 - - key: positively regulates - source: UniProt:P35367 - target: GO:0004969 - - key: participates in - source: GO:0004969 - target: GO:0071420 - - key: positively correlated with - source: GO:0071420 - target: GO:0006954 - - key: causes - source: GO:0006954 - target: MESH:D003233 - multigraph: true - nodes: - - id: MESH:D016589 - label: Drug - name: Astemizole - - id: UniProt:P35367 - label: Protein - name: Histamine H1 receptor - - id: GO:0004969 - label: MolecularActivity - name: Histamine receptor activity - - id: GO:0071420 - label: BiologicalProcess - name: Cellular response to histamine - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: MESH:D003233 - label: Disease - name: Allergic conjunctivitis - reference: - - https://go.drugbank.com/drugs/DB00637 -- directed: true - graph: - disease: Chronic idiopathic urticaria - disease_mesh: MESH:D000080223 - drug: Astemizole - drug_mesh: MESH:D016589 - drugbank: DB:DB00637 - links: - - key: decreases activity of - source: MESH:D016589 - target: UniProt:P35367 - - key: positively regulates - source: UniProt:P35367 - target: GO:0004969 - - key: participates in - source: GO:0004969 - target: GO:0071420 - - key: positively correlated with - source: GO:0071420 - target: GO:0006954 - - key: positively correlated with - source: GO:0071420 - target: GO:0043117 - - key: positively correlated with - source: GO:0071420 - target: HP:0000969 - - key: manifestation of - source: HP:0000969 - target: MESH:D000080223 - - key: manifestation of - source: GO:0043117 - target: MESH:D000080223 - - key: causes - source: GO:0006954 - target: MESH:D000080223 - multigraph: true - nodes: - - id: MESH:D016589 - label: Drug - name: Astemizole - - id: UniProt:P35367 - label: Protein - name: Histamine H1 receptor - - id: GO:0004969 - label: MolecularActivity - name: Histamine receptor activity - - id: GO:0071420 - label: BiologicalProcess - name: Cellular response to histamine - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: GO:0043117 - label: BiologicalProcess - name: Positive regulation of vascular permeability - - id: HP:0000969 - label: PhenotypicFeature - name: Edema - - id: MESH:D000080223 - label: Disease - name: Chronic idiopathic urticaria - reference: - - https://go.drugbank.com/drugs/DB00637 -- directed: true - graph: - disease: Allergic rhinitis - disease_mesh: MESH:D065631 - drug: Astemizole - drug_mesh: MESH:D016589 - drugbank: DB:DB00637 - links: - - key: decreases activity of - source: MESH:D016589 - target: UniProt:P35367 - - key: positively regulates - source: UniProt:P35367 - target: GO:0004969 - - key: participates in - source: GO:0004969 - target: GO:0071420 - - key: positively correlated with - source: GO:0071420 - target: GO:0006954 - - key: has phenotype - source: GO:0006954 - target: HP:0031417 - - key: manifestation of - source: HP:0031417 - target: MESH:D065631 - multigraph: true - nodes: - - id: MESH:D016589 - label: Drug - name: Astemizole - - id: UniProt:P35367 - label: Protein - name: Histamine H1 receptor - - id: GO:0004969 - label: MolecularActivity - name: Histamine receptor activity - - id: GO:0071420 - label: BiologicalProcess - name: Cellular response to histamine - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: HP:0031417 - label: PhenotypicFeature - name: Rhinorrhea - - id: MESH:D065631 - label: Disease - name: Allergic rhinitis - reference: - - https://go.drugbank.com/drugs/DB00637 -- directed: true - graph: - disease: Primary cutaneous T-cell lymphoma - disease_mesh: MESH:D016410 - drug: fluocinonide - drug_mesh: MESH:D005447 - drugbank: DB:DB01047 - links: - - key: increases activity of - source: MESH:D005447 - target: UniProt:P04150 - - key: increases activity of - source: UniProt:P04150 - target: UniProt:P04083 - - key: decreases activity of - source: UniProt:P04083 - target: UniProt:P47712 - - key: decreases activity of - source: UniProt:P04083 - target: UniProt:P35354 - - key: increases abundance of - source: UniProt:P47712 - target: MESH:D011453 - - key: increases abundance of - source: UniProt:P35354 - target: MESH:D011453 - - key: positively regulates - source: MESH:D011453 - target: GO:0006954 - - key: has phenotype - source: GO:0006954 - target: HP:0000989 - - key: has phenotype - source: GO:0006954 - target: HP:0000988 - - key: manifestation of - source: HP:0000989 - target: MESH:D016410 - - key: manifestation of - source: HP:0000988 - target: MESH:D016410 - multigraph: true - nodes: - - id: MESH:D005447 - label: Drug - name: Fluocinonide - - id: UniProt:P04150 - label: Protein - name: Glucocorticoid receptor - - id: UniProt:P04083 - label: Protein - name: Annexin A1 - - id: UniProt:P47712 - label: Protein - name: Cytosolic phospholipase A2 - - id: UniProt:P35354 - label: Protein - name: Prostaglandin G/H synthase 2 - - id: MESH:D011453 - label: ChemicalSubstance - name: Prostaglandins - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: HP:0000989 - label: PhenotypicFeature - name: Pruritus - - id: HP:0000988 - label: PhenotypicFeature - name: Skin rash - - id: MESH:D016410 - label: Disease - name: Primary cutaneous T-cell lymphoma - reference: - - https://go.drugbank.com/drugs/DB01047 -- directed: true - graph: - disease: Discoid lupus erythematosus - disease_mesh: MESH:D008179 - drug: fluocinonide - drug_mesh: MESH:D005447 - drugbank: DB:DB01047 - links: - - key: increases activity of - source: MESH:D005447 - target: UniProt:P04150 - - key: increases activity of - source: UniProt:P04150 - target: UniProt:P04083 - - key: decreases activity of - source: UniProt:P04083 - target: UniProt:P47712 - - key: decreases activity of - source: UniProt:P04083 - target: UniProt:P35354 - - key: increases abundance of - source: UniProt:P47712 - target: MESH:D011453 - - key: increases abundance of - source: UniProt:P35354 - target: MESH:D011453 - - key: positively regulates - source: MESH:D011453 - target: GO:0006954 - - key: positively correlated with - source: GO:0006954 - target: MESH:D008179 - multigraph: true - nodes: - - id: MESH:D005447 - label: Drug - name: Fluocinonide - - id: UniProt:P04150 - label: Protein - name: Glucocorticoid receptor - - id: UniProt:P04083 - label: Protein - name: Annexin A1 - - id: UniProt:P47712 - label: Protein - name: Cytosolic phospholipase A2 - - id: UniProt:P35354 - label: Protein - name: Prostaglandin G/H synthase 2 - - id: MESH:D011453 - label: ChemicalSubstance - name: Prostaglandins - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: MESH:D008179 - label: Disease - name: Discoid lupus erythematosus - reference: - - https://go.drugbank.com/drugs/DB01047 -- directed: true - graph: - disease: Pruritus ani - disease_mesh: MESH:D011538 - drug: fluocinonide - drug_mesh: MESH:D005447 - drugbank: DB:DB01047 - links: - - key: increases activity of - source: MESH:D005447 - target: UniProt:P04150 - - key: increases activity of - source: UniProt:P04150 - target: UniProt:P04083 - - key: decreases activity of - source: UniProt:P04083 - target: UniProt:P47712 - - key: decreases activity of - source: UniProt:P04083 - target: UniProt:P35354 - - key: increases abundance of - source: UniProt:P47712 - target: MESH:D011453 - - key: increases abundance of - source: UniProt:P35354 - target: MESH:D011453 - - key: positively regulates - source: MESH:D011453 - target: GO:0006954 - - key: has phenotype - source: GO:0006954 - target: HP:0000989 - - key: manifestation of - source: HP:0000989 - target: MESH:D011538 - multigraph: true - nodes: - - id: MESH:D005447 - label: Drug - name: Fluocinonide - - id: UniProt:P04150 - label: Protein - name: Glucocorticoid receptor - - id: UniProt:P04083 - label: Protein - name: Annexin A1 - - id: UniProt:P47712 - label: Protein - name: Cytosolic phospholipase A2 - - id: UniProt:P35354 - label: Protein - name: Prostaglandin G/H synthase 2 - - id: MESH:D011453 - label: ChemicalSubstance - name: Prostaglandins - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: HP:0000989 - label: PhenotypicFeature - name: Pruritus - - id: MESH:D011538 - label: Disease - name: Pruritus ani - reference: - - https://go.drugbank.com/drugs/DB01047 -- directed: true - graph: - disease: Granuloma annulare - disease_mesh: MESH:D016460 - drug: fluocinonide - drug_mesh: MESH:D005447 - drugbank: DB:DB01047 - links: - - key: increases activity of - source: MESH:D005447 - target: UniProt:P04150 - - key: increases activity of - source: UniProt:P04150 - target: UniProt:P04083 - - key: decreases activity of - source: UniProt:P04083 - target: UniProt:P47712 - - key: decreases activity of - source: UniProt:P04083 - target: UniProt:P35354 - - key: increases abundance of - source: UniProt:P47712 - target: MESH:D011453 - - key: increases abundance of - source: UniProt:P35354 - target: MESH:D011453 - - key: positively regulates - source: MESH:D011453 - target: GO:0006954 - - key: positively correlated with - source: GO:0006954 - target: MESH:D016460 - multigraph: true - nodes: - - id: MESH:D005447 - label: Drug - name: Fluocinonide - - id: UniProt:P04150 - label: Protein - name: Glucocorticoid receptor - - id: UniProt:P04083 - label: Protein - name: Annexin A1 - - id: UniProt:P47712 - label: Protein - name: Cytosolic phospholipase A2 - - id: UniProt:P35354 - label: Protein - name: Prostaglandin G/H synthase 2 - - id: MESH:D011453 - label: ChemicalSubstance - name: Prostaglandins - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: MESH:D016460 - label: Disease - name: Granuloma annulare - reference: - - https://go.drugbank.com/drugs/DB01047 -- directed: true - graph: - disease: Eruption of skin - disease_mesh: MESH:D005076 - drug: fluocinonide - drug_mesh: MESH:D005447 - drugbank: DB:DB01047 - links: - - key: increases activity of - source: MESH:D005447 - target: UniProt:P04150 - - key: increases activity of - source: UniProt:P04150 - target: UniProt:P04083 - - key: decreases activity of - source: UniProt:P04083 - target: UniProt:P47712 - - key: decreases activity of - source: UniProt:P04083 - target: UniProt:P35354 - - key: increases abundance of - source: UniProt:P47712 - target: MESH:D011453 - - key: increases abundance of - source: UniProt:P35354 - target: MESH:D011453 - - key: positively regulates - source: MESH:D011453 - target: GO:0006954 - - key: positively correlated with - source: GO:0006954 - target: MESH:D005076 - multigraph: true - nodes: - - id: MESH:D005447 - label: Drug - name: Fluocinonide - - id: UniProt:P04150 - label: Protein - name: Glucocorticoid receptor - - id: UniProt:P04083 - label: Protein - name: Annexin A1 - - id: UniProt:P47712 - label: Protein - name: Cytosolic phospholipase A2 - - id: UniProt:P35354 - label: Protein - name: Prostaglandin G/H synthase 2 - - id: MESH:D011453 - label: ChemicalSubstance - name: Prostaglandins - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: MESH:D005076 - label: Disease - name: Eruption of skin - reference: - - https://go.drugbank.com/drugs/DB01047 -- directed: true - graph: - disease: Contact dermatitis - disease_mesh: MESH:D003877 - drug: fluocinonide - drug_mesh: MESH:D005447 - drugbank: DB:DB01047 - links: - - key: increases activity of - source: MESH:D005447 - target: UniProt:P04150 - - key: increases activity of - source: UniProt:P04150 - target: UniProt:P04083 - - key: decreases activity of - source: UniProt:P04083 - target: UniProt:P47712 - - key: decreases activity of - source: UniProt:P04083 - target: UniProt:P35354 - - key: increases abundance of - source: UniProt:P47712 - target: MESH:D011453 - - key: increases abundance of - source: UniProt:P35354 - target: MESH:D011453 - - key: positively regulates - source: MESH:D011453 - target: GO:0006954 - - key: positively correlated with - source: GO:0006954 - target: MESH:D003877 - multigraph: true - nodes: - - id: MESH:D005447 - label: Drug - name: Fluocinonide - - id: UniProt:P04150 - label: Protein - name: Glucocorticoid receptor - - id: UniProt:P04083 - label: Protein - name: Annexin A1 - - id: UniProt:P47712 - label: Protein - name: Cytosolic phospholipase A2 - - id: UniProt:P35354 - label: Protein - name: Prostaglandin G/H synthase 2 - - id: MESH:D011453 - label: ChemicalSubstance - name: Prostaglandins - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: MESH:D003877 - label: Disease - name: Contact dermatitis - reference: - - https://go.drugbank.com/drugs/DB01047 -- directed: true - graph: - disease: Seborrheic dermatitis - disease_mesh: MESH:D012628 - drug: fluocinonide - drug_mesh: MESH:D005447 - drugbank: DB:DB010473 - links: - - key: increases activity of - source: MESH:D005447 - target: UniProt:P04150 - - key: increases activity of - source: UniProt:P04150 - target: UniProt:P04083 - - key: decreases activity of - source: UniProt:P04083 - target: UniProt:P47712 - - key: decreases activity of - source: UniProt:P04083 - target: UniProt:P35354 - - key: increases abundance of - source: UniProt:P47712 - target: MESH:D011453 - - key: increases abundance of - source: UniProt:P35354 - target: MESH:D011453 - - key: positively regulates - source: MESH:D011453 - target: GO:0006954 - - key: has phenotype - source: GO:0006954 - target: HP:0000989 - - key: manifestation of - source: HP:0000989 - target: MESH:D012628 - multigraph: true - nodes: - - id: MESH:D005447 - label: Drug - name: Fluocinonide - - id: UniProt:P04150 - label: Protein - name: Glucocorticoid receptor - - id: UniProt:P04083 - label: Protein - name: Annexin A1 - - id: UniProt:P47712 - label: Protein - name: Cytosolic phospholipase A2 - - id: UniProt:P35354 - label: Protein - name: Prostaglandin G/H synthase 2 - - id: MESH:D011453 - label: ChemicalSubstance - name: Prostaglandins - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: HP:0000989 - label: PhenotypicFeature - name: Pruritus - - id: MESH:D012628 - label: Disease - name: Seborrheic dermatitis - reference: - - https://go.drugbank.com/drugs/DB01047 -- directed: true - graph: - disease: Lichen simplex chronicus - disease_mesh: MESH:D009450 - drug: fluocinonide - drug_mesh: MESH:D005447 - drugbank: DB:DB010473 - links: - - key: increases activity of - source: MESH:D005447 - target: UniProt:P04150 - - key: increases activity of - source: UniProt:P04150 - target: UniProt:P04083 - - key: decreases activity of - source: UniProt:P04083 - target: UniProt:P47712 - - key: decreases activity of - source: UniProt:P04083 - target: UniProt:P35354 - - key: increases abundance of - source: UniProt:P47712 - target: MESH:D011453 - - key: increases abundance of - source: UniProt:P35354 - target: MESH:D011453 - - key: positively regulates - source: MESH:D011453 - target: GO:0006954 - - key: has phenotype - source: GO:0006954 - target: HP:0000989 - - key: manifestation of - source: HP:0000989 - target: MESH:D009450 - multigraph: true - nodes: - - id: MESH:D005447 - label: Drug - name: Fluocinonide - - id: UniProt:P04150 - label: Protein - name: Glucocorticoid receptor - - id: UniProt:P04083 - label: Protein - name: Annexin A1 - - id: UniProt:P47712 - label: Protein - name: Cytosolic phospholipase A2 - - id: UniProt:P35354 - label: Protein - name: Prostaglandin G/H synthase 2 - - id: MESH:D011453 - label: ChemicalSubstance - name: Prostaglandins - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: HP:0000989 - label: PhenotypicFeature - name: Pruritus - - id: MESH:D009450 - label: Disease - name: Lichen simplex chronicus - reference: - - https://go.drugbank.com/drugs/DB01047 -- directed: true - graph: - disease: Atopic dermatitis - disease_mesh: MESH:D003876 - drug: fluocinonide - drug_mesh: MESH:D005447 - drugbank: DB:DB010473 - links: - - key: increases activity of - source: MESH:D005447 - target: UniProt:P04150 - - key: increases activity of - source: UniProt:P04150 - target: UniProt:P04083 - - key: decreases activity of - source: UniProt:P04083 - target: UniProt:P47712 - - key: decreases activity of - source: UniProt:P04083 - target: UniProt:P35354 - - key: increases abundance of - source: UniProt:P47712 - target: MESH:D011453 - - key: increases abundance of - source: UniProt:P35354 - target: MESH:D011453 - - key: positively regulates - source: MESH:D011453 - target: GO:0006954 - - key: has phenotype - source: GO:0006954 - target: HP:0000989 - - key: has phenotype - source: GO:0006954 - target: HP:0000969 - - key: manifestation of - source: HP:0000989 - target: MESH:D003876 - - key: manifestation of - source: HP:0000969 - target: MESH:D003876 - multigraph: true - nodes: - - id: MESH:D005447 - label: Drug - name: Fluocinonide - - id: UniProt:P04150 - label: Protein - name: Glucocorticoid receptor - - id: UniProt:P04083 - label: Protein - name: Annexin A1 - - id: UniProt:P47712 - label: Protein - name: Cytosolic phospholipase A2 - - id: UniProt:P35354 - label: Protein - name: Prostaglandin G/H synthase 2 - - id: MESH:D011453 - label: ChemicalSubstance - name: Prostaglandins - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: HP:0000989 - label: PhenotypicFeature - name: Pruritus - - id: HP:0000969 - label: PhenotypicFeature - name: Edema - - id: MESH:D003876 - label: Disease - name: Atopic dermatitis - reference: - - https://go.drugbank.com/drugs/DB01047 -- directed: true - graph: - disease: Bipolar disorder - disease_mesh: MESH:D001714 - drug: lithium carbonate - drug_mesh: MESH:D016651 - drugbank: DB:DB01356 - links: - - key: decreases activity of - source: MESH:D016651 - target: UniProt:P29218 - - key: positively regulates - source: UniProt:P29218 - target: GO:0046855 - - key: increases abundance of - source: GO:0046855 - target: MESH:D007294 - - key: positively regulates - source: MESH:D007294 - target: GO:0043647 - - key: positively regulates - source: GO:0043647 - target: GO:0014047 - - key: positively correlated with - source: GO:0014047 - target: MESH:D001714 - - key: decreases activity of - source: MESH:D016651 - target: UniProt:P4984 - - key: positively correlated with - source: UniProt:P4984 - target: HP:0000713 - - key: occurs in - source: HP:0000713 - target: MESH:D001714 - - key: positively regulates - source: MESH:D016651 - target: GO:0061534 - - key: negatively correlated with - source: GO:0061534 - target: MESH:D001714 - - key: negatively regulates - source: MESH:D016651 - target: GO:0061527 - - key: positively correlated with - source: GO:0061527 - target: MESH:D001714 - - key: negatively regulates - source: MESH:D016651 - target: GO:0004972 - - key: positively correlated with - source: GO:0004972 - target: MESH:D018698 - - key: positively correlated with - source: MESH:D018698 - target: MESH:D001714 - multigraph: true - nodes: - - id: MESH:D016651 - label: Drug - name: Lithium carbonate - - id: UniProt:P29218 - label: Protein - name: Inositol monophosphatase 1 - - id: GO:0046855 - label: BiologicalProcess - name: Inositol phosphate dephosphorylation - - id: MESH:D007294 - label: BiologicalProcess - name: Inositol - - id: GO:0043647 - label: BiologicalProcess - name: Inositol phosphate metabolic process - - id: GO:0014047 - label: BiologicalProcess - name: Glutamate secretion - - id: UniProt:P4984 - label: Protein - name: Glycogen synthase kinase-3 beta - - id: HP:0000713 - label: PhenotypicFeature - name: Agitation - - id: GO:0061534 - label: BiologicalProcess - name: Gamma-aminobutyric acid secretion, neurotransmission - - id: GO:0061527 - label: BiologicalProcess - name: Dopamine secretion, neurotransmission - - id: GO:0004972 - label: MolecularActivity - name: NMDA glutamate receptor activity - - id: MESH:D018698 - label: ChemicalSubstance - name: Glutamic Acid - - id: MESH:D001714 - label: Disease - name: Bipolar disorder - reference: - - https://pubmed.ncbi.nlm.nih.gov/23371914/ - - https://go.drugbank.com/drugs/DB14509 - - https://en.wikipedia.org/wiki/Lithium_(medication)#Bipolar_disorder -- directed: true - graph: - disease: Headache disorder - disease_mesh: MESH:D020773 - drug: lithium carbonate - drug_mesh: MESH:D016651 - drugbank: DB:DB01356 - links: - - key: decreases activity of - source: MESH:D016651 - target: UniProt:P29218 - - key: positively regulates - source: UniProt:P29218 - target: GO:0046855 - - key: increases abundance of - source: GO:0046855 - target: MESH:D007294 - - key: positively regulates - source: MESH:D007294 - target: GO:0043647 - - key: positively regulates - source: GO:0043647 - target: GO:0014047 - - key: positively correlated with - source: GO:0014047 - target: GO:0019233 - - key: negatively regulates - source: MESH:D016651 - target: GO:0004972 - - key: positively correlated with - source: GO:0004972 - target: MESH:D018698 - - key: positively correlated with - source: MESH:D018698 - target: GO:0061535 - - key: positively correlated with - source: GO:0061535 - target: GO:0019233 - - key: positively correlated with - source: GO:0019233 - target: MESH:D020773 - multigraph: true - nodes: - - id: MESH:D016651 - label: Drug - name: Lithium carbonate - - id: UniProt:P29218 - label: Protein - name: Inositol monophosphatase 1 - - id: GO:0046855 - label: BiologicalProcess - name: Inositol phosphate dephosphorylation - - id: MESH:D007294 - label: BiologicalProcess - name: Inositol - - id: GO:0043647 - label: BiologicalProcess - name: Inositol phosphate metabolic process - - id: GO:0014047 - label: BiologicalProcess - name: Glutamate secretion - - id: GO:0019233 - label: BiologicalProcess - name: Sensory perception of pain - - id: GO:0004972 - label: MolecularActivity - name: NMDA glutamate receptor activity - - id: MESH:D018698 - label: ChemicalSubstance - name: Glutamic Acid - - id: GO:0061535 - label: BiologicalProcess - name: Glutamate secretion, neurotransmission - - id: MESH:D020773 - label: Disease - name: Headache disorder - reference: - - https://go.drugbank.com/drugs/DB14509 -- directed: true - graph: - disease: Pain - disease_mesh: MESH:D010146 - drug: lithium carbonate - drug_mesh: MESH:D016651 - drugbank: DB:DB01356 - links: - - key: decreases activity of - source: MESH:D016651 - target: UniProt:P29218 - - key: positively regulates - source: UniProt:P29218 - target: GO:0046855 - - key: increases abundance of - source: GO:0046855 - target: MESH:D007294 - - key: positively regulates - source: MESH:D007294 - target: GO:0043647 - - key: positively regulates - source: GO:0043647 - target: GO:0014047 - - key: positively correlated with - source: GO:0014047 - target: GO:0019233 - - key: negatively regulates - source: MESH:D016651 - target: GO:0004972 - - key: positively correlated with - source: GO:0004972 - target: MESH:D018698 - - key: positively correlated with - source: MESH:D018698 - target: GO:0061535 - - key: positively correlated with - source: GO:0061535 - target: GO:0019233 - - key: positively correlated with - source: GO:0019233 - target: MESH:D010146 - multigraph: true - nodes: - - id: MESH:D016651 - label: Drug - name: Lithium carbonate - - id: UniProt:P29218 - label: Protein - name: Inositol monophosphatase 1 - - id: GO:0046855 - label: BiologicalProcess - name: Inositol phosphate dephosphorylation - - id: MESH:D007294 - label: BiologicalProcess - name: Inositol - - id: GO:0043647 - label: BiologicalProcess - name: Inositol phosphate metabolic process - - id: GO:0014047 - label: BiologicalProcess - name: Glutamate secretion - - id: GO:0019233 - label: BiologicalProcess - name: Sensory perception of pain - - id: GO:0004972 - label: MolecularActivity - name: NMDA glutamate receptor activity - - id: MESH:D018698 - label: ChemicalSubstance - name: Glutamic Acid - - id: GO:0061535 - label: BiologicalProcess - name: Glutamate secretion, neurotransmission - - id: MESH:D010146 - label: Disease - name: Pain - reference: - - https://go.drugbank.com/drugs/DB14509 -- comment: Lithium can cause side effects such as fever. - directed: true - graph: - disease: Fever - disease_mesh: MESH:D005334 - drug: lithium carbonate - drug_mesh: MESH:D016651 - drugbank: DB:DB01356 - links: - - key: causes - source: MESH:D016651 - target: MESH:D005334 - multigraph: true - nodes: - - id: MESH:D016651 - label: Drug - name: Lithium carbonate - - id: MESH:D005334 - label: Disease - name: Fever - reference: - - https://en.wikipedia.org/wiki/Lithium_toxicity - - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164879/ -- directed: true - graph: - disease: Osteoarthritis - disease_mesh: MESH:D010003 - drug: lithium carbonate - drug_mesh: MESH:D016651 - drugbank: DB:DB01356 - links: - - key: decreases activity of - source: MESH:D016651 - target: UniProt:P29218 - - key: positively regulates - source: UniProt:P29218 - target: GO:0046855 - - key: increases abundance of - source: GO:0046855 - target: MESH:D007294 - - key: positively regulates - source: MESH:D007294 - target: GO:0043647 - - key: positively regulates - source: GO:0043647 - target: GO:0014047 - - key: positively correlated with - source: GO:0014047 - target: GO:0019233 - - key: negatively regulates - source: MESH:D016651 - target: GO:0004972 - - key: positively correlated with - source: GO:0004972 - target: MESH:D018698 - - key: positively correlated with - source: MESH:D018698 - target: GO:0061535 - - key: positively correlated with - source: GO:0061535 - target: GO:0019233 - - key: positively correlated with - source: GO:0019233 - target: MESH:D010003 - multigraph: true - nodes: - - id: MESH:D016651 - label: Drug - name: Lithium carbonate - - id: UniProt:P29218 - label: Protein - name: Inositol monophosphatase 1 - - id: GO:0046855 - label: BiologicalProcess - name: Inositol phosphate dephosphorylation - - id: MESH:D007294 - label: BiologicalProcess - name: Inositol - - id: GO:0043647 - label: BiologicalProcess - name: Inositol phosphate metabolic process - - id: GO:0014047 - label: BiologicalProcess - name: Glutamate secretion - - id: GO:0019233 - label: BiologicalProcess - name: Sensory perception of pain - - id: GO:0004972 - label: MolecularActivity - name: NMDA glutamate receptor activity - - id: MESH:D018698 - label: ChemicalSubstance - name: Glutamic Acid - - id: GO:0061535 - label: BiologicalProcess - name: Glutamate secretion, neurotransmission - - id: MESH:D010003 - label: Disease - name: Osteoarthritis - reference: - - https://go.drugbank.com/drugs/DB14509 -- directed: true - graph: - disease: Juvenile rheumatoid arthritis - disease_mesh: MESH:D001171 - drug: lithium carbonate - drug_mesh: MESH:D016651 - drugbank: DB:DB01356 - links: - - key: decreases activity of - source: MESH:D016651 - target: UniProt:P29218 - - key: positively regulates - source: UniProt:P29218 - target: GO:0046855 - - key: increases abundance of - source: GO:0046855 - target: MESH:D007294 - - key: positively regulates - source: MESH:D007294 - target: GO:0043647 - - key: positively regulates - source: GO:0043647 - target: GO:0014047 - - key: positively correlated with - source: GO:0014047 - target: GO:0019233 - - key: negatively regulates - source: MESH:D016651 - target: GO:0004972 - - key: positively correlated with - source: GO:0004972 - target: MESH:D018698 - - key: positively correlated with - source: MESH:D018698 - target: GO:0061535 - - key: positively correlated with - source: GO:0061535 - target: GO:0019233 - - key: positively correlated with - source: GO:0019233 - target: MESH:D001171 - multigraph: true - nodes: - - id: MESH:D016651 - label: Drug - name: Lithium carbonate - - id: UniProt:P29218 - label: Protein - name: Inositol monophosphatase 1 - - id: GO:0046855 - label: BiologicalProcess - name: Inositol phosphate dephosphorylation - - id: MESH:D007294 - label: BiologicalProcess - name: Inositol - - id: GO:0043647 - label: BiologicalProcess - name: Inositol phosphate metabolic process - - id: GO:0014047 - label: BiologicalProcess - name: Glutamate secretion - - id: GO:0019233 - label: BiologicalProcess - name: Sensory perception of pain - - id: GO:0004972 - label: MolecularActivity - name: NMDA glutamate receptor activity - - id: MESH:D018698 - label: ChemicalSubstance - name: Glutamic Acid - - id: GO:0061535 - label: BiologicalProcess - name: Glutamate secretion, neurotransmission - - id: MESH:D001171 - label: Disease - name: Juvenile rheumatoid arthritis - reference: - - https://go.drugbank.com/drugs/DB14509 -- directed: true - graph: - disease: Rheumatoid arthritis - disease_mesh: MESH:D001172 - drug: lithium carbonate - drug_mesh: MESH:D016651 - drugbank: DB:DB01356 - links: - - key: decreases activity of - source: MESH:D016651 - target: UniProt:P29218 - - key: positively regulates - source: UniProt:P29218 - target: GO:0046855 - - key: increases abundance of - source: GO:0046855 - target: MESH:D007294 - - key: positively regulates - source: MESH:D007294 - target: GO:0043647 - - key: positively regulates - source: GO:0043647 - target: GO:0014047 - - key: positively correlated with - source: GO:0014047 - target: GO:0019233 - - key: negatively regulates - source: MESH:D016651 - target: GO:0004972 - - key: positively correlated with - source: GO:0004972 - target: MESH:D018698 - - key: positively correlated with - source: MESH:D018698 - target: GO:0061535 - - key: positively correlated with - source: GO:0061535 - target: GO:0019233 - - key: positively correlated with - source: GO:0019233 - target: MESH:D001172 - multigraph: true - nodes: - - id: MESH:D016651 - label: Drug - name: Lithium carbonate - - id: UniProt:P29218 - label: Protein - name: Inositol monophosphatase 1 - - id: GO:0046855 - label: BiologicalProcess - name: Inositol phosphate dephosphorylation - - id: MESH:D007294 - label: BiologicalProcess - name: Inositol - - id: GO:0043647 - label: BiologicalProcess - name: Inositol phosphate metabolic process - - id: GO:0014047 - label: BiologicalProcess - name: Glutamate secretion - - id: GO:0019233 - label: BiologicalProcess - name: Sensory perception of pain - - id: GO:0004972 - label: MolecularActivity - name: NMDA glutamate receptor activity - - id: MESH:D018698 - label: ChemicalSubstance - name: Glutamic Acid - - id: GO:0061535 - label: BiologicalProcess - name: Glutamate secretion, neurotransmission - - id: MESH:D001172 - label: Disease - name: Rheumatoid arthritis - reference: - - https://go.drugbank.com/drugs/DB14509 -- directed: true - graph: - disease: Dysmenorrhea - disease_mesh: MESH:D004412 - drug: lithium carbonate - drug_mesh: MESH:D016651 - drugbank: DB:DB01356 - links: - - key: decreases activity of - source: MESH:D016651 - target: UniProt:P29218 - - key: positively regulates - source: UniProt:P29218 - target: GO:0046855 - - key: increases abundance of - source: GO:0046855 - target: MESH:D007294 - - key: positively regulates - source: MESH:D007294 - target: GO:0043647 - - key: positively regulates - source: GO:0043647 - target: GO:0014047 - - key: positively correlated with - source: GO:0014047 - target: GO:0019233 - - key: negatively regulates - source: MESH:D016651 - target: GO:0004972 - - key: positively correlated with - source: GO:0004972 - target: MESH:D018698 - - key: positively correlated with - source: MESH:D018698 - target: GO:0061535 - - key: positively correlated with - source: GO:0061535 - target: GO:0019233 - - key: positively correlated with - source: GO:0019233 - target: MESH:D004412 - multigraph: true - nodes: - - id: MESH:D016651 - label: Drug - name: Lithium carbonate - - id: UniProt:P29218 - label: Protein - name: Inositol monophosphatase 1 - - id: GO:0046855 - label: BiologicalProcess - name: Inositol phosphate dephosphorylation - - id: MESH:D007294 - label: BiologicalProcess - name: Inositol - - id: GO:0043647 - label: BiologicalProcess - name: Inositol phosphate metabolic process - - id: GO:0014047 - label: BiologicalProcess - name: Glutamate secretion - - id: GO:0019233 - label: BiologicalProcess - name: Sensory perception of pain - - id: GO:0004972 - label: MolecularActivity - name: NMDA glutamate receptor activity - - id: MESH:D018698 - label: ChemicalSubstance - name: Glutamic Acid - - id: GO:0061535 - label: BiologicalProcess - name: Glutamate secretion, neurotransmission - - id: MESH:D004412 - label: Disease - name: Dysmenorrhea - reference: - - https://go.drugbank.com/drugs/DB14509 -- directed: true - graph: - disease: Tear film insufficiency - disease_mesh: MESH:D015352 - drug: lifitegrast - drug_mesh: MESH:C575157 - drugbank: DB:DB11611 - links: - - key: decreases activity of - source: MESH:C575157 - target: UniProt:P20701 - - key: positively correlated with - source: UniProt:P20701 - target: GO:0042110 - - key: positively correlated with - source: UniProt:P20701 - target: GO:0042098 - - key: positively correlated with - source: GO:0042110 - target: GO:0006954 - - key: positively correlated with - source: GO:0042098 - target: GO:0006954 - - key: occurs in - source: GO:0006954 - target: MESH:D015352 - multigraph: true - nodes: - - id: MESH:C575157 - label: Drug - name: Lifitegrast - - id: UniProt:P20701 - label: Protein - name: Integrin alpha-L - - id: GO:0042098 - label: BiologicalProcess - name: T cell proliferation - - id: GO:0042110 - label: BiologicalProcess - name: T cell activation - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: MESH:D015352 - label: Disease - name: Tear film insufficiency - reference: - - https://go.drugbank.com/drugs/DB11611 - - https://en.wikipedia.org/wiki/Lifitegrast -- directed: true - graph: - disease: Hemorrhagic disease of the newborn due to vitamin K deficiency - disease_mesh: MESH:D006475 - drug: menatetrenone - drug_mesh: MESH:C030814 - drugbank: DB:DB12148 - links: - - key: increases activity of - source: MESH:C030814 - target: UniProt:P38435 - - key: positively regulates - source: UniProt:P38435 - target: GO:0007596 - - key: negatively correlated with - source: GO:0007596 - target: MESH:D006475 - multigraph: true - nodes: - - id: MESH:C030814 - label: Drug - name: Menatetrenone - - id: UniProt:P38435 - label: Protein - name: Vitamin K-dependent gamma-carboxylase - - id: GO:0007596 - label: BiologicalProcess - name: Blood coagulation - - id: MESH:D006475 - label: Disease - name: Hemorrhagic disease of the newborn due to vitamin K deficiency - reference: - - https://en.wikipedia.org/wiki/Vitamin_K2#Mechanism_of_action +