Merge pull request #138 from TripSit/Issue52again

4mmc + MDMA
TripSit · Jun 13, 2024 · a5fcd3b · a5fcd3b
2 parents 5f0701b + 1e17b35
commit a5fcd3b
Show file tree

Hide file tree

Showing 2 changed files with 184 additions and 0 deletions.
diff --git a/combos.json b/combos.json
@@ -2583,6 +2583,52 @@
       "note": "MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAO-A inhibitors with MDMA will lead to hypertensive crises.",
       "status": "Dangerous"
     },
+    "mephedrone": {
+      "note": "Risk of serotonin syndrome as both drugs raise serotonin levels. Stimulants also increase the neurotoxic effects of MDMA, in addition to concerns of high blood pressure and unnecessary strain on the heart. As well as potentially causing anxiety and greater physical discomfort due to the combination.",
+      "sources": [
+        {
+          "author": "J Kehr,  F Ichinose,  S Yoshitake,  M Goiny,  T Sievertsson,  F Nyberg,  T Yoshitake",
+          "title": "Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats",
+          "url": "https://doi.org/10.1111/j.1476-5381.2011.01499.x"
+        },
+        {
+          "author": "Gregory C. Hadlock, Katy M. Webb, Lisa M. McFadden, Pei Wen Chu, Jonathan D. Ellis, Scott C. Allen, David M. Andrenyak, Paula L. Vieira-Brock, Christopher L. German, Kevin M. Conrad, Amanda J. Hoonakker, James W. Gibb, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein",
+          "title": "4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse",
+          "url": "https://doi.org/10.1124/jpet.111.184119 "
+        },
+        {
+          "author": "Gough B, Ali SF, Slikker W Jr, Holson RR. ",
+          "title": "Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate. (1991)",
+          "url": "https://doi.org/10.1016/0091-3057(91)90137-q"
+        },
+        {
+          "author": "Schmidt CJ, Levin JA, Lovenberg W. ",
+          "title": "In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain. (1987)",
+          "url": "https://doi.org/10.1016/0006-2952(87)90729-5"
+        },
+        {
+          "author": "Bankson MG, Cunningham KA.",
+          "title": "3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions. (2001)",
+          "url": "https://pubmed.ncbi.nlm.nih.gov/11356903/"
+        },
+        {
+          "author": "A.C. Parrott",
+          "title": "Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity (2002)",
+          "url": "https://doi.org/10.1016/S0091-3057(01)00711-0"
+        },
+        {
+          "author": "Lisa H. Gold & George F. Koob ",
+          "title": "MDMA produces stimulant-like conditioned locomotor activity. (1989)",
+          "url": "https://doi.org/10.1007/BF00445556"
+        },
+        {
+          "author": "Meng H, Cao J, Kang J, Ying X, Ji J, Reynolds W, Rampe D.",
+          "title": "Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat ",
+          "url": "https://doi.org/10.1016/j.toxlet.2011.10.010"
+        }
+      ],
+      "status": "Dangerous"
+    },
     "mescaline": {
       "status": "Low Risk & Synergy"
     },
@@ -2672,6 +2718,52 @@
         }
       ],
       "status": "Dangerous"
+    },
+    "mdma": {
+      "note": "Risk of serotonin syndrome as both drugs raise serotonin levels. Stimulants also increase the neurotoxic effects of MDMA, in addition to concerns of high blood pressure and unnecessary strain on the heart. As well as potentially causing anxiety and greater physical discomfort due to the combination.",
+      "sources": [
+        {
+          "author": "J Kehr,  F Ichinose,  S Yoshitake,  M Goiny,  T Sievertsson,  F Nyberg,  T Yoshitake",
+          "title": "Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats",
+          "url": "https://doi.org/10.1111/j.1476-5381.2011.01499.x"
+        },
+        {
+          "author": "Gregory C. Hadlock, Katy M. Webb, Lisa M. McFadden, Pei Wen Chu, Jonathan D. Ellis, Scott C. Allen, David M. Andrenyak, Paula L. Vieira-Brock, Christopher L. German, Kevin M. Conrad, Amanda J. Hoonakker, James W. Gibb, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein",
+          "title": "4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse",
+          "url": "https://doi.org/10.1124/jpet.111.184119 "
+        },
+        {
+          "author": "Gough B, Ali SF, Slikker W Jr, Holson RR. ",
+          "title": "Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate. (1991)",
+          "url": "https://doi.org/10.1016/0091-3057(91)90137-q"
+        },
+        {
+          "author": "Schmidt CJ, Levin JA, Lovenberg W. ",
+          "title": "In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain. (1987)",
+          "url": "https://doi.org/10.1016/0006-2952(87)90729-5"
+        },
+        {
+          "author": "Bankson MG, Cunningham KA.",
+          "title": "3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions. (2001)",
+          "url": "https://pubmed.ncbi.nlm.nih.gov/11356903/"
+        },
+        {
+          "author": "A.C. Parrott",
+          "title": "Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity (2002)",
+          "url": "https://doi.org/10.1016/S0091-3057(01)00711-0"
+        },
+        {
+          "author": "Lisa H. Gold & George F. Koob ",
+          "title": "MDMA produces stimulant-like conditioned locomotor activity. (1989)",
+          "url": "https://doi.org/10.1007/BF00445556"
+        },
+        {
+          "author": "Meng H, Cao J, Kang J, Ying X, Ji J, Reynolds W, Rampe D.",
+          "title": "Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat ",
+          "url": "https://doi.org/10.1016/j.toxlet.2011.10.010"
+        }
+      ],
+      "status": "Dangerous"
     }
   },
   "mescaline": {

diff --git a/drugs.json b/drugs.json
@@ -24844,6 +24844,52 @@
         "note": "MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAO-A inhibitors with MDMA will lead to hypertensive crises.",
         "status": "Dangerous"
       },
+      "mephedrone": {
+        "note": "Risk of serotonin syndrome as both drugs raise serotonin levels. Stimulants also increase the neurotoxic effects of MDMA, in addition to concerns of high blood pressure and unnecessary strain on the heart. As well as potentially causing anxiety and greater physical discomfort due to the combination.",
+        "sources": [
+          {
+            "author": "J Kehr,  F Ichinose,  S Yoshitake,  M Goiny,  T Sievertsson,  F Nyberg,  T Yoshitake",
+            "title": "Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats",
+            "url": "https://doi.org/10.1111/j.1476-5381.2011.01499.x"
+          },
+          {
+            "author": "Gregory C. Hadlock, Katy M. Webb, Lisa M. McFadden, Pei Wen Chu, Jonathan D. Ellis, Scott C. Allen, David M. Andrenyak, Paula L. Vieira-Brock, Christopher L. German, Kevin M. Conrad, Amanda J. Hoonakker, James W. Gibb, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein",
+            "title": "4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse",
+            "url": "https://doi.org/10.1124/jpet.111.184119 "
+          },
+          {
+            "author": "Gough B, Ali SF, Slikker W Jr, Holson RR. ",
+            "title": "Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate. (1991)",
+            "url": "https://doi.org/10.1016/0091-3057(91)90137-q"
+          },
+          {
+            "author": "Schmidt CJ, Levin JA, Lovenberg W. ",
+            "title": "In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain. (1987)",
+            "url": "https://doi.org/10.1016/0006-2952(87)90729-5"
+          },
+          {
+            "author": "Bankson MG, Cunningham KA.",
+            "title": "3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions. (2001)",
+            "url": "https://pubmed.ncbi.nlm.nih.gov/11356903/"
+          },
+          {
+            "author": "A.C. Parrott",
+            "title": "Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity (2002)",
+            "url": "https://doi.org/10.1016/S0091-3057(01)00711-0"
+          },
+          {
+            "author": "Lisa H. Gold & George F. Koob ",
+            "title": "MDMA produces stimulant-like conditioned locomotor activity. (1989)",
+            "url": "https://doi.org/10.1007/BF00445556"
+          },
+          {
+            "author": "Meng H, Cao J, Kang J, Ying X, Ji J, Reynolds W, Rampe D.",
+            "title": "Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat ",
+            "url": "https://doi.org/10.1016/j.toxlet.2011.10.010"
+          }
+        ],
+        "status": "Dangerous"
+      },
       "mescaline": {
         "status": "Low Risk & Synergy"
       },
@@ -25640,6 +25686,52 @@
           }
         ],
         "status": "Dangerous"
+      },
+      "mdma": {
+        "note": "Risk of serotonin syndrome as both drugs raise serotonin levels. Stimulants also increase the neurotoxic effects of MDMA, in addition to concerns of high blood pressure and unnecessary strain on the heart. As well as potentially causing anxiety and greater physical discomfort due to the combination.",
+        "sources": [
+          {
+            "author": "J Kehr,  F Ichinose,  S Yoshitake,  M Goiny,  T Sievertsson,  F Nyberg,  T Yoshitake",
+            "title": "Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats",
+            "url": "https://doi.org/10.1111/j.1476-5381.2011.01499.x"
+          },
+          {
+            "author": "Gregory C. Hadlock, Katy M. Webb, Lisa M. McFadden, Pei Wen Chu, Jonathan D. Ellis, Scott C. Allen, David M. Andrenyak, Paula L. Vieira-Brock, Christopher L. German, Kevin M. Conrad, Amanda J. Hoonakker, James W. Gibb, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein",
+            "title": "4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse",
+            "url": "https://doi.org/10.1124/jpet.111.184119 "
+          },
+          {
+            "author": "Gough B, Ali SF, Slikker W Jr, Holson RR. ",
+            "title": "Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate. (1991)",
+            "url": "https://doi.org/10.1016/0091-3057(91)90137-q"
+          },
+          {
+            "author": "Schmidt CJ, Levin JA, Lovenberg W. ",
+            "title": "In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain. (1987)",
+            "url": "https://doi.org/10.1016/0006-2952(87)90729-5"
+          },
+          {
+            "author": "Bankson MG, Cunningham KA.",
+            "title": "3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions. (2001)",
+            "url": "https://pubmed.ncbi.nlm.nih.gov/11356903/"
+          },
+          {
+            "author": "A.C. Parrott",
+            "title": "Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity (2002)",
+            "url": "https://doi.org/10.1016/S0091-3057(01)00711-0"
+          },
+          {
+            "author": "Lisa H. Gold & George F. Koob ",
+            "title": "MDMA produces stimulant-like conditioned locomotor activity. (1989)",
+            "url": "https://doi.org/10.1007/BF00445556"
+          },
+          {
+            "author": "Meng H, Cao J, Kang J, Ying X, Ji J, Reynolds W, Rampe D.",
+            "title": "Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat ",
+            "url": "https://doi.org/10.1016/j.toxlet.2011.10.010"
+          }
+        ],
+        "status": "Dangerous"
       }
     },
     "formatted_aftereffects": {