diff --git a/ports/mimxrt/mphalport.h b/ports/mimxrt/mphalport.h
index c69ebf58106b..a0e457502442 100644
--- a/ports/mimxrt/mphalport.h
+++ b/ports/mimxrt/mphalport.h
@@ -109,6 +109,10 @@ __attribute__((always_inline)) static inline uint32_t disable_irq(void) {
 
 void mp_hal_set_interrupt_char(int c);
 
+static inline void mp_hal_wake_main_task_from_isr(void) {
+    // Defined for tinyusb support, nothing needs to be done here.
+}
+
 static inline mp_uint_t mp_hal_ticks_ms(void) {
     return ticks_ms32();
 }
diff --git a/ports/nrf/mphalport.h b/ports/nrf/mphalport.h
index 50c61aefcdd5..a0bca58a625b 100644
--- a/ports/nrf/mphalport.h
+++ b/ports/nrf/mphalport.h
@@ -53,6 +53,10 @@ void mp_hal_set_interrupt_char(int c); // -1 to disable
 int mp_hal_stdin_rx_chr(void);
 void mp_hal_stdout_tx_str(const char *str);
 
+static inline void mp_hal_wake_main_task_from_isr(void) {
+    // Defined for tinyusb support, nothing needs to be done here.
+}
+
 void mp_hal_delay_ms(mp_uint_t ms);
 void mp_hal_delay_us(mp_uint_t us);
 
diff --git a/ports/renesas-ra/mphalport.h b/ports/renesas-ra/mphalport.h
index 14e6ee0c3eea..0819abeaf617 100644
--- a/ports/renesas-ra/mphalport.h
+++ b/ports/renesas-ra/mphalport.h
@@ -52,6 +52,10 @@ static inline int mp_hal_status_to_neg_errno(HAL_StatusTypeDef status) {
 NORETURN void mp_hal_raise(HAL_StatusTypeDef status);
 void mp_hal_set_interrupt_char(int c); // -1 to disable
 
+static inline void mp_hal_wake_main_task_from_isr(void) {
+    // Defined for tinyusb support, nothing needs to be done here.
+}
+
 // timing functions
 
 #include "irq.h"
diff --git a/ports/rp2/mphalport.h b/ports/rp2/mphalport.h
index 16ac4259a6fe..09ad54dd1eb7 100644
--- a/ports/rp2/mphalport.h
+++ b/ports/rp2/mphalport.h
@@ -77,6 +77,10 @@ void mp_thread_end_atomic_section(uint32_t);
 void mp_hal_set_interrupt_char(int c);
 void mp_hal_time_ns_set_from_rtc(void);
 
+static inline void mp_hal_wake_main_task_from_isr(void) {
+    // Defined for tinyusb support, nothing needs to be done here.
+}
+
 static inline void mp_hal_delay_us_fast(mp_uint_t us) {
     busy_wait_us(us);
 }
diff --git a/ports/samd/mphalport.h b/ports/samd/mphalport.h
index ee1ebf7aea2b..6c9e525bb916 100644
--- a/ports/samd/mphalport.h
+++ b/ports/samd/mphalport.h
@@ -50,6 +50,10 @@ uint64_t mp_hal_ticks_us_64(void);
 
 void mp_hal_set_interrupt_char(int c);
 
+static inline void mp_hal_wake_main_task_from_isr(void) {
+    // Defined for tinyusb support, nothing needs to be done here.
+}
+
 __attribute__((always_inline)) static inline void enable_irq(uint32_t state) {
     __set_PRIMASK(state);
 }
diff --git a/shared/tinyusb/mp_usbd.c b/shared/tinyusb/mp_usbd.c
index 436314dcde5c..7ccfa7018d4b 100644
--- a/shared/tinyusb/mp_usbd.c
+++ b/shared/tinyusb/mp_usbd.c
@@ -24,7 +24,7 @@
  * THE SOFTWARE.
  */
 
-#include "py/mpconfig.h"
+#include "py/mphal.h"
 
 #if MICROPY_HW_ENABLE_USBDEV
 
@@ -55,6 +55,7 @@ extern void __real_dcd_event_handler(dcd_event_t const *event, bool in_isr);
 TU_ATTR_FAST_FUNC void __wrap_dcd_event_handler(dcd_event_t const *event, bool in_isr) {
     __real_dcd_event_handler(event, in_isr);
     mp_usbd_schedule_task();
+    mp_hal_wake_main_task_from_isr();
 }
 
 TU_ATTR_FAST_FUNC void mp_usbd_schedule_task(void) {