MyChem drugcentral bioactivity: what to do when action_type is missing

[colleenXu]

MyChem's drugcentral.bioactivity info is a resource for detailed chem-gene relationship information. We currently use the field action_type to help map the data to biolink predicate/qualifier info (ex: the value "AGONIST" -> affects / causes increased activity using agonism). The action_type field seems to correspond to the "Action" column in the DrugCentral webpages (ex: compare the drugcentral.bioactivity data for bupropion in MyChem vs DrugCentral's webpage).

However, as you can see in the bupropion links, there's a LOT of data that doesn't have an action_type value: the field is missing in the MyChem API data and is blank on the DrugCentral webpage. I'm not sure how to quantify it in MyChem, but I know there's 763 / 3225 chemicals in MyChem's drugcentral bioactivity data that are MISSING action_type for ALL of their gene relationships.

In order to make this data available to Translator, there's two things we'd need to figure out:

• we're not sure how to model it with biolink-model: what predicate to use? Affects?
• we're not sure how to query for it in the BioThings API. It's complicated when chemicals have a mix of data with the action_type and without it. -> Trying to ask Chunlei and co.