diff --git a/flask_s3.py b/flask_s3.py
index ff2f220..39eedce 100644
--- a/flask_s3.py
+++ b/flask_s3.py
@@ -39,6 +39,15 @@
 
 __version__ = (0, 2, 10)
 
+
+def _get_statics_prefix(app):
+    """
+    Get the complete prefix that should be used by static files.
+    """
+    upload_prefix = app.config.get('FLASKS3_PREFIX', '')
+    return '/%s' % upload_prefix.lstrip('/').rstrip('/')
+
+
 def split_metadata_params(headers):
     """
     Given a dict of headers for s3, seperates those that are boto3
@@ -122,6 +131,10 @@ def url_for(endpoint, **values):
 
         if app.config['FLASKS3_CDN_DOMAIN']:
             bucket_path = '%s' % app.config['FLASKS3_CDN_DOMAIN']
+
+        # Both S3 and CDN urls should use the prefix if it exists
+        bucket_path += _get_statics_prefix(app).rstrip('/')
+
         urls = app.url_map.bind(bucket_path, url_scheme=scheme)
         return urls.build(endpoint, values=values, force_external=True)
     return flask_url_for(endpoint, **values)
@@ -271,9 +284,11 @@ def _write_files(s3, app, static_url_loc, static_folder, files, bucket,
 
 def _upload_files(s3, app, files_, bucket, hashes=None):
     new_hashes = []
+    prefix = _get_statics_prefix(app)
     for (static_folder, static_url), names in six.iteritems(files_):
-        new_hashes.extend(_write_files(s3, app, static_url, static_folder, names,
-                                       bucket, hashes=hashes))
+        static_upload_url = '%s/%s' % (prefix.rstrip('/'), static_url.lstrip('/'))
+        new_hashes.extend(_write_files(s3, app, static_upload_url, static_folder,
+                                       names, bucket, hashes=hashes))
     return new_hashes
 
 
@@ -473,7 +488,9 @@ def init_app(self, app):
                     ('FLASKS3_URL_STYLE', 'host'),
                     ('FLASKS3_GZIP', False),
                     ('FLASKS3_GZIP_ONLY_EXTS', []),
-                    ('FLASKS3_FORCE_MIMETYPE', False)]
+                    ('FLASKS3_FORCE_MIMETYPE', False),
+                    ('FLASKS3_PREFIX', '')]
+
 
         for k, v in defaults:
             app.config.setdefault(k, v)
diff --git a/test_flask_static.py b/test_flask_static.py
index 598523e..0ab1eff 100644
--- a/test_flask_static.py
+++ b/test_flask_static.py
@@ -182,6 +182,7 @@ def setUp(self):
         self.app.config['FLASKS3_BUCKET_NAME'] = 'foo'
         self.app.config['FLASKS3_USE_CACHE_CONTROL'] = True
         self.app.config['FLASKS3_CACHE_CONTROL'] = 'cache instruction'
+        self.app.config['S3_CACHE_CONTROL'] = '3600'
         self.app.config['FLASKS3_HEADERS'] = {
             'Expires': 'Thu, 31 Dec 2037 23:59:59 GMT',
             'Content-Encoding': 'gzip',
@@ -394,6 +395,44 @@ def test_static_folder_path(self):
         for i, e in zip(inputs, expected):
             self.assertEquals(e, flask_s3._static_folder_path(*i))
 
+    @patch('flask_s3._write_files')
+    def test__upload_uses_prefix(self, mock_write_files):
+        s3_mock = Mock()
+        local_path = '/local_path/static'
+        file_paths = ['/local_path/static/file1', '/local_path/static/file2']
+        files = {(local_path, '/static'): file_paths}
+
+        flask_s3._upload_files(s3_mock, self.app, files, 's3_bucket')
+        expected_call = call(
+            s3_mock, self.app, '/static', local_path, file_paths, 's3_bucket', hashes=None)
+        self.assertEquals(mock_write_files.call_args_list, [expected_call])
+
+        for supported_prefix in ['foo', '/foo', 'foo/', '/foo/']:
+            mock_write_files.reset_mock()
+            self.app.config['FLASKS3_PREFIX'] = supported_prefix
+            flask_s3._upload_files(s3_mock, self.app, files, 's3_bucket')
+            expected_call = call(s3_mock, self.app, '/foo/static',
+                                 local_path, file_paths, 's3_bucket', hashes=None)
+            self.assertEquals(mock_write_files.call_args_list, [expected_call])
+
+    @patch('flask_s3.current_app')
+    def test__url_for_uses_prefix(self, mock_current_app):
+        bucket_path = 'foo.s3.amazonaws.com'
+        flask_s3.FlaskS3(self.app)
+        mock_current_app.config = self.app.config
+        mock_bind = mock_current_app.url_map.bind
+
+        flask_s3.url_for('static', **{'filename': 'test_file.txt'})
+        self.assertEqual(mock_bind.call_args_list, [call(bucket_path, url_scheme='https')])
+
+        for supported_prefix in ['bar', '/bar', 'bar/', '/bar/']:
+            mock_bind.reset_mock()
+            self.app.config['FLASKS3_PREFIX'] = supported_prefix
+            flask_s3.url_for('static', **{'filename': 'test_file.txt'})
+            expected_path = '%s/%s' % (bucket_path, 'bar')
+            self.assertEqual(mock_bind.call_args_list,
+                             [call(expected_path, url_scheme='https')])
+
 
 if __name__ == '__main__':
     unittest.main()