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Statement.score clarification #223

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ahwagner opened this issue Nov 25, 2024 · 1 comment
Open

Statement.score clarification #223

ahwagner opened this issue Nov 25, 2024 · 1 comment

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@ahwagner
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the "score" may need to be better defined; the number is meaningless without further information, e.g. does this represent a log2-odds ratio? This was undoubtedly added in response to upcoming ACMG v4 guidelines, and would also support existing ClinGen/CGC/VICC guidelines for Oncogenicity. We need to provide guidance on how this score should be interpreted. It could be as simple as updating the description to indicate that the score must be interpreted in the context of the specifiedIn document.

@mbrush
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mbrush commented Nov 25, 2024

I added text to this effect as part of my PR reviewing/updating class and attribute descriptions. I also assume that profiles that use/extend the core score attribute can provide a more specific description for how to interpret its values in their profile specification.

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