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Colocalization of two proteins #29

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dariushghasemi opened this issue Dec 3, 2024 · 1 comment
Open

Colocalization of two proteins #29

dariushghasemi opened this issue Dec 3, 2024 · 1 comment
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documentation Improvements or additions to documentation

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@dariushghasemi
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Here we perform colocalization analysis using the coloc v5.2.3 (2023-09-22).
We follow some steps here:

  • we cross tabulate credible set SNPs for two independent SNPs for two different proteins,
  • once there is s common SNP between the two credible sets, we store corresponding conditional data of the two independent SNPs.
  • repeat this analysis for all combinations of independent signals from one proteins against all other proteins to attain all possible combinations of the traits we need to perform coloc,
  • conduct main colocalization analysis of two traits using the input created in previous steps.
@dariushghasemi dariushghasemi self-assigned this Dec 3, 2024
@dariushghasemi dariushghasemi added the documentation Improvements or additions to documentation label Dec 3, 2024
dariushghasemi added a commit that referenced this issue Dec 5, 2024
fix definition of input and output files
@dariushghasemi
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The coloc analysis with previous version of the Nicola's pipe has been run successfully. Here we try to update the function computing l-ABF to the latest version removing NULL from the conditional dataset.

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