diff --git a/sqlx-mysql/src/connection/stream.rs b/sqlx-mysql/src/connection/stream.rs
index e42c15d9e5..c225256da2 100644
--- a/sqlx-mysql/src/connection/stream.rs
+++ b/sqlx-mysql/src/connection/stream.rs
@@ -1,7 +1,7 @@
 use std::collections::VecDeque;
 use std::ops::{Deref, DerefMut};
 
-use bytes::{Buf, Bytes};
+use bytes::{Buf, Bytes, BytesMut};
 
 use crate::collation::{CharSet, Collation};
 use crate::error::Error;
@@ -126,9 +126,7 @@ impl<S: Socket> MySqlStream<S> {
             .write_with(Packet(payload), (self.capabilities, &mut self.sequence_id));
     }
 
-    // receive the next packet from the database server
-    // may block (async) on more data from the server
-    pub(crate) async fn recv_packet(&mut self) -> Result<Packet<Bytes>, Error> {
+    async fn recv_packet_part(&mut self) -> Result<Bytes, Error> {
         // https://dev.mysql.com/doc/dev/mysql-server/8.0.12/page_protocol_basic_packets.html
         // https://mariadb.com/kb/en/library/0-packet/#standard-packet
 
@@ -142,10 +140,33 @@ impl<S: Socket> MySqlStream<S> {
         let payload: Bytes = self.socket.read(packet_size).await?;
 
         // TODO: packet compression
-        // TODO: packet joining
+
+        Ok(payload)
+    }
+
+    // receive the next packet from the database server
+    // may block (async) on more data from the server
+    pub(crate) async fn recv_packet(&mut self) -> Result<Packet<Bytes>, Error> {
+        let payload = self.recv_packet_part().await?;
+        let payload = if payload.len() < 0xFF_FF_FF {
+            payload
+        } else {
+            let mut final_payload = BytesMut::with_capacity(0xFF_FF_FF * 2);
+            final_payload.extend_from_slice(&payload);
+
+            drop(payload); // we don't need the allocation anymore
+
+            let mut last_read = 0xFF_FF_FF;
+            while last_read == 0xFF_FF_FF {
+                let part = self.recv_packet_part().await?;
+                last_read = part.len();
+                final_payload.extend_from_slice(&part);
+            }
+            final_payload.into()
+        };
 
         if payload
-            .get(0)
+            .first()
             .ok_or(err_protocol!("Packet empty"))?
             .eq(&0xff)
         {
diff --git a/sqlx-mysql/src/protocol/packet.rs b/sqlx-mysql/src/protocol/packet.rs
index 2d40ba8e77..9d0d46c35a 100644
--- a/sqlx-mysql/src/protocol/packet.rs
+++ b/sqlx-mysql/src/protocol/packet.rs
@@ -1,3 +1,4 @@
+use std::cmp::min;
 use std::ops::{Deref, DerefMut};
 
 use bytes::Bytes;
@@ -19,6 +20,14 @@ where
         buf: &mut Vec<u8>,
         (capabilities, sequence_id): (Capabilities, &'stream mut u8),
     ) {
+        let mut next_header = |len: u32| {
+            let mut buf = len.to_le_bytes();
+            buf[3] = *sequence_id;
+            *sequence_id = sequence_id.wrapping_add(1);
+
+            buf
+        };
+
         // reserve space to write the prefixed length
         let offset = buf.len();
         buf.extend(&[0_u8; 4]);
@@ -31,13 +40,25 @@ where
         let len = buf.len() - offset - 4;
         let header = &mut buf[offset..];
 
-        // FIXME: Support larger packets
-        assert!(len < 0xFF_FF_FF);
+        header[..4].copy_from_slice(&next_header(min(len, 0xFF_FF_FF) as u32));
 
-        header[..4].copy_from_slice(&(len as u32).to_le_bytes());
-        header[3] = *sequence_id;
+        // add more packets if we need to split the data
+        if len >= 0xFF_FF_FF {
+            let rest = buf.split_off(offset + 4 + 0xFF_FF_FF);
+            let mut chunks = rest.chunks_exact(0xFF_FF_FF);
 
-        *sequence_id = sequence_id.wrapping_add(1);
+            for chunk in chunks.by_ref() {
+                buf.reserve(chunk.len() + 4);
+                buf.extend(&next_header(chunk.len() as u32));
+                buf.extend(chunk);
+            }
+
+            // this will also handle adding a zero sized packet if the data size is a multiple of 0xFF_FF_FF
+            let remainder = chunks.remainder();
+            buf.reserve(remainder.len() + 4);
+            buf.extend(&next_header(remainder.len() as u32));
+            buf.extend(remainder);
+        }
     }
 }
 
diff --git a/tests/mysql/mysql.rs b/tests/mysql/mysql.rs
index ba57a01d8e..586cef2ed0 100644
--- a/tests/mysql/mysql.rs
+++ b/tests/mysql/mysql.rs
@@ -447,6 +447,39 @@ async fn it_can_work_with_transactions() -> anyhow::Result<()> {
     Ok(())
 }
 
+#[sqlx_macros::test]
+async fn it_can_handle_split_packets() -> anyhow::Result<()> {
+    // This will only take effect on new connections
+    new::<MySql>()
+        .await?
+        .execute("SET GLOBAL max_allowed_packet = 4294967297")
+        .await?;
+
+    let mut conn = new::<MySql>().await?;
+
+    conn.execute(
+        r#"
+CREATE TEMPORARY TABLE large_table (data LONGBLOB);
+        "#,
+    )
+    .await?;
+
+    let data = vec![0x41; 0xFF_FF_FF * 2];
+
+    sqlx::query("INSERT INTO large_table (data) VALUES (?)")
+        .bind(&data)
+        .execute(&mut conn)
+        .await?;
+
+    let ret: Vec<u8> = sqlx::query_scalar("SELECT * FROM large_table")
+        .fetch_one(&mut conn)
+        .await?;
+
+    assert_eq!(ret, data);
+
+    Ok(())
+}
+
 #[sqlx_macros::test]
 async fn test_shrink_buffers() -> anyhow::Result<()> {
     // We don't really have a good way to test that `.shrink_buffers()` functions as expected