2024-01-23-abousamra24a.md

title	abstract	layout	series	publisher	issn	id	month	tex_title	firstpage	lastpage	page	order	cycles	bibtex_author	author	date	address	container-title	volume	genre	issued	pdf	extras
Unsupervised Stain Decomposition via Inversion Regulation for Multiplex Immunohistochemistry Images	Multiplex Immunohistochemistry (mIHC) is a cost-effective and accessible method for in situ labeling of multiple protein biomarkers in a tissue sample. By assigning a different stain to each biomarker, it allows the visualization of different types of cells within the tumor vicinity for downstream analysis. However, to detect different types of stains in a given mIHC image is a challenging problem, especially when the number of stains is high. Previous deep-learning-based methods mostly assume full supervision; yet the annotation can be costly. In this paper, we propose a novel unsupervised stain decomposition method to detect different stains simultaneously. Our method does not require any supervision, except for color samples of different stains. A main technical challenge is that the problem is underdetermined and can have multiple solutions. To conquer this issue, we propose a novel inversion regulation technique, which eliminates most undesirable solutions. On a 7-plexed IHC image dataset, the proposed method achieves high quality stain decomposition results without human annotation.	inproceedings	Proceedings of Machine Learning Research	PMLR	2640-3498	abousamra24a	0	Unsupervised Stain Decomposition via Inversion Regulation for Multiplex Immunohistochemistry Images	74	94	74-94	74	false	Abousamra, Shahira and Fassler, Danielle and Yao, Jiachen and Gupta, Rajarsi R. and Kurc, Tahsin and Escobar-Hoyos, Luisa and Samaras, Dimitris and Shroyer, Kenneth and Saltz, Joel and Chen, Chao	given family Shahira Abousamra given family Danielle Fassler given family Jiachen Yao given family Rajarsi R. Gupta given family Tahsin Kurc given family Luisa Escobar-Hoyos given family Dimitris Samaras given family Kenneth Shroyer given family Joel Saltz given family Chao Chen	2024-01-23		Medical Imaging with Deep Learning	227	inproceedings	date-parts 2024 1 23	https://proceedings.mlr.press/v227/abousamra24a/abousamra24a.pdf