diff --git a/.bumpversion.cfg b/.bumpversion.cfg
deleted file mode 100644
index a1c533f6..00000000
--- a/.bumpversion.cfg
+++ /dev/null
@@ -1,20 +0,0 @@
-[bumpversion]
-current_version = 0.8.4.dev0
-commit = True
-tag = True
-sign_tags = True
-parse = (?P<major>\d+)\.(?P<minor>\d+)\.(?P<patch>\d+)(\.(?P<release>[a-z]+)(?P<build>\d+))?
-serialize = 
-	{major}.{minor}.{patch}.{release}{build}
-	{major}.{minor}.{patch}
-
-[bumpversion:part:release]
-optional_value = prod
-first_value = dev
-values = 
-	dev
-	prod
-
-[bumpversion:part:build]
-
-[bumpversion:file:setup.py]
diff --git a/.github/workflows/publish_pypi.yml b/.github/workflows/publish_pypi.yml
index 436eafbf..b58f5720 100644
--- a/.github/workflows/publish_pypi.yml
+++ b/.github/workflows/publish_pypi.yml
@@ -11,8 +11,8 @@ jobs:
       - uses: actions/setup-python@v4
       - name: Build a binary wheel and a source tarball
         run: |
-          python -mpip install wheel
-          python setup.py sdist bdist_wheel
+          python -mpip install wheel build
+          python -m build
       - name: Publish distribution to PyPI
         if: startsWith(github.ref, 'refs/tags')
         uses: pypa/gh-action-pypi-publish@v1.3.0
diff --git a/.isort.cfg b/.isort.cfg
index fec62009..0f1f7e33 100644
--- a/.isort.cfg
+++ b/.isort.cfg
@@ -1,5 +1,5 @@
 [settings]
-known_third_party = dask,numcodecs,numpy,pytest,scipy,setuptools,skimage,zarr
+known_third_party = dask,numcodecs,numpy,pytest,scipy,skimage,zarr
 multi_line_output = 3
 include_trailing_comma = True
 force_grid_wrap = 0
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 00000000..c43cd5a5
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,61 @@
+[build-system]
+requires = [
+    "setuptools>=60",
+    "setuptools-scm>=8.0",
+]
+
+[tools.setuptools.dynamic]
+version = {attr = "ome_zarr.__version__"}
+
+[project]
+name = "ome-zarr"
+readme = "README.rst"
+dynamic = ["version"]
+description="Implementation of images in Zarr files."
+
+requires-python = ">3.8"
+
+dependencies = [
+    "tifffile",
+    "numpy",
+    "dask",
+    "distributed",
+    "zarr>=2.8.1",
+    "fsspec[s3]>=0.8,!=2021.07.0",
+    # See https://github.com/fsspec/filesystem_spec/issues/819
+    "aiohttp<4",
+    "requests",
+    "scikit-image",
+    "toolz",
+]
+classifiers = [
+    "Development Status :: 4 - Beta",
+    "Intended Audience :: Developers",
+    "Intended Audience :: Science/Research",
+    "Topic :: Software Development :: Libraries :: Python Modules",
+    "Programming Language :: Python",
+    "Programming Language :: Python :: 3",
+    "Operating System :: OS Independent",
+    "License :: OSI Approved :: BSD License",
+]
+
+authors = [
+    {name = "The Open Microscopy Team"},
+]
+
+[project.entry-points."console_scripts"]
+ome_zarr = "ome_zarr.cli:main"
+
+[project.optional-dependencies]
+tests = [
+    "pytest",
+]
+
+[project.urls]
+Documentation = "https://ome-zarr.readthedocs.io"
+Repository = "https://github.com/ome/ome-zarr-py"
+Changelog = "https://github.com/ome/ome-zarr-py/blob/master/CHANGELOG.md"
+
+[tool.setuptools]
+packages = ["ome_zarr"]
+py-modules = ["ome_zarr"]
diff --git a/setup.py b/setup.py
deleted file mode 100644
index 56c0145f..00000000
--- a/setup.py
+++ /dev/null
@@ -1,55 +0,0 @@
-#!/usr/bin/env python
-
-import codecs
-import os
-from typing import List
-
-from setuptools import setup
-
-
-def read(fname):
-    file_path = os.path.join(os.path.dirname(__file__), fname)
-    return codecs.open(file_path, encoding="utf-8").read()
-
-
-install_requires: List[List[str]] = []
-install_requires += (["dataclasses;python_version<'3.7'"],)
-install_requires += (["tifffile<2020.09.22;python_version<'3.7'"],)
-install_requires += (["numpy"],)
-install_requires += (["dask"],)
-install_requires += (["distributed"],)
-install_requires += (["zarr>=2.8.1"],)
-install_requires += (["fsspec[s3]>=0.8,!=2021.07.0"],)
-# See https://github.com/fsspec/filesystem_spec/issues/819
-install_requires += (["aiohttp<4"],)
-install_requires += (["requests"],)
-install_requires += (["scikit-image"],)
-install_requires += (["toolz"],)
-
-
-setup(
-    name="ome-zarr",
-    version="0.8.4.dev0",
-    author="The Open Microscopy Team",
-    url="https://github.com/ome/ome-zarr-py",
-    description="Implementation of images in Zarr files.",
-    long_description=read("README.rst"),
-    packages=["ome_zarr"],
-    py_modules=["ome_zarr"],
-    python_requires=">=3.6",
-    install_requires=install_requires,
-    classifiers=[
-        "Development Status :: 4 - Beta",
-        "Intended Audience :: Developers",
-        "Intended Audience :: Science/Research",
-        "Topic :: Software Development :: Libraries :: Python Modules",
-        "Programming Language :: Python",
-        "Programming Language :: Python :: 3",
-        "Operating System :: OS Independent",
-        "License :: OSI Approved :: BSD License",
-    ],
-    entry_points={
-        "console_scripts": ["ome_zarr = ome_zarr.cli:main"],
-    },
-    tests_require=["pytest"],
-)