diff --git a/src/qibo/backends/__init__.py b/src/qibo/backends/__init__.py
index 75fd502479..eb743a50d6 100644
--- a/src/qibo/backends/__init__.py
+++ b/src/qibo/backends/__init__.py
@@ -111,6 +111,7 @@ def _create_backend(cls):
     @classmethod
     def set_backend(cls, backend, **kwargs):
         cls._backend = construct_backend(backend, **kwargs)
+        cls._transpiler = None
         log.info(f"Using {cls._backend} backend on {cls._backend.device}")
 
     @classmethod