diff --git a/ci/build_wheel.sh b/ci/build_wheel.sh
index c72dd946..e467a698 100755
--- a/ci/build_wheel.sh
+++ b/ci/build_wheel.sh
@@ -56,4 +56,6 @@ mkdir -p final_dist
 python -m auditwheel repair -w final_dist dist/*
 ls -1 final_dist | grep -vqz 'none'
 
+../../ci/validate_wheel.sh final_dist
+
 RAPIDS_PY_WHEEL_NAME="${package_name}_${RAPIDS_PY_CUDA_SUFFIX}" rapids-upload-wheels-to-s3 final_dist
diff --git a/ci/validate_wheel.sh b/ci/validate_wheel.sh
new file mode 100755
index 00000000..60a80fce
--- /dev/null
+++ b/ci/validate_wheel.sh
@@ -0,0 +1,18 @@
+#!/bin/bash
+# Copyright (c) 2024, NVIDIA CORPORATION.
+
+set -euo pipefail
+
+wheel_dir_relative_path=$1
+
+rapids-logger "validate packages with 'pydistcheck'"
+
+pydistcheck \
+    --inspect \
+    "$(echo ${wheel_dir_relative_path}/*.whl)"
+
+rapids-logger "validate packages with 'twine'"
+
+twine check \
+    --strict \
+    "$(echo ${wheel_dir_relative_path}/*.whl)"
diff --git a/python/cucim/pyproject.toml b/python/cucim/pyproject.toml
index 25248b3b..8b54160a 100644
--- a/python/cucim/pyproject.toml
+++ b/python/cucim/pyproject.toml
@@ -115,6 +115,14 @@ where = ["src"]
 [tool.setuptools.package-data]
 mypkg = ["*.pyi", "*.h", "*.cu", "VERSION"]
 
+[tool.pydistcheck]
+select = [
+    "distro-too-large-compressed",
+]
+
+# PyPI limit is 100 MiB, fail CI before we get too close to that
+max_allowed_size_compressed = '75M'
+
 [tool.pytest.ini_options]
 # If a pytest section is found in one of the possible config files
 # (pytest.ini, tox.ini or setup.cfg), then pytest will not look for any others,