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MHC / xMHC genomic coordinates for rat & mouse #8

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dhimmel opened this issue Oct 15, 2021 · 0 comments
Open

MHC / xMHC genomic coordinates for rat & mouse #8

dhimmel opened this issue Oct 15, 2021 · 0 comments

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@dhimmel
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dhimmel commented Oct 15, 2021

Following #4, we now support human, mouse, and rat exports. However, in the species configuration for mouse and rat, we set enable_mhc=False because we haven't yet put in accurate coordinates for the major histocompatibility complex region and extended MHC in these species.

See the code that needs updating for mouse

# FIXME: mhc coordinates (H2 complex)
# https://doi.org/10.1002/9780470015902.a0000921.pub4
enable_mhc=False,
mhc_chromosome="17",
mhc_lower=28_510_120,
mhc_upper=33_480_577,
xmhc_lower=25_726_063,
xmhc_upper=33_410_226,

And for rat

# FIXME: mhc coordinates
# https://github.com/related-sciences/ensembl-genes/pull/6#discussion_r729259953
enable_mhc=False,
mhc_chromosome="20",
mhc_lower=28_510_120,
mhc_upper=33_480_577,
xmhc_lower=25_726_063,
xmhc_upper=33_410_226,

If anyone stumbles on this issue and can help that would be much appreciated! We will want coordinates in the assembly specified for each species: currently GRCm39 for mouse and Rnor_6.0 for rat.

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