diff --git a/depends/builders/darwin.mk b/depends/builders/darwin.mk
index 27f550ab03..8ed82b276d 100644
--- a/depends/builders/darwin.mk
+++ b/depends/builders/darwin.mk
@@ -1,17 +1,18 @@
-build_darwin_CC: = $(shell xcrun -f clang)
-build_darwin_CXX: = $(shell xcrun -f clang++)
-build_darwin_AR: = $(shell xcrun -f ar)
-build_darwin_RANLIB: = $(shell xcrun -f ranlib)
-build_darwin_STRIP: = $(shell xcrun -f strip)
-build_darwin_OTOOL: = $(shell xcrun -f otool)
-build_darwin_NM: = $(shell xcrun -f nm)
+build_darwin_CC:=$(shell xcrun -f clang) -isysroot$(shell xcrun --show-sdk-path)
+build_darwin_CXX:=$(shell xcrun -f clang++) -isysroot$(shell xcrun --show-sdk-path)
+build_darwin_AR:=$(shell xcrun -f ar)
+build_darwin_RANLIB:=$(shell xcrun -f ranlib)
+build_darwin_STRIP:=$(shell xcrun -f strip)
+build_darwin_OTOOL:=$(shell xcrun -f otool)
+build_darwin_NM:=$(shell xcrun -f nm)
 build_darwin_INSTALL_NAME_TOOL:=$(shell xcrun -f install_name_tool)
-build_darwin_SHA256SUM = shasum -a 256
-build_darwin_DOWNLOAD = curl --location --fail --connect-timeout $(DOWNLOAD_CONNECT_TIMEOUT) --retry $(DOWNLOAD_RETRIES) -o
+build_darwin_DSYMUTIL:=$(shell xcrun -f dsymutil)
+build_darwin_SHA256SUM=shasum -a 256
+build_darwin_DOWNLOAD=curl --location --fail --connect-timeout $(DOWNLOAD_CONNECT_TIMEOUT) --retry $(DOWNLOAD_RETRIES) -o
 
 #darwin host on darwin builder. overrides darwin host preferences.
-darwin_CC=$(shell xcrun -f clang) -mmacosx-version-min=$(OSX_MIN_VERSION)
-darwin_CXX:=$(shell xcrun -f clang++) -mmacosx-version-min=$(OSX_MIN_VERSION) -stdlib=libc++
+darwin_CC=$(shell xcrun -f clang) -mmacosx-version-min=$(OSX_MIN_VERSION) -isysroot$(shell xcrun --show-sdk-path)
+darwin_CXX:=$(shell xcrun -f clang++) -mmacosx-version-min=$(OSX_MIN_VERSION) -stdlib=libc++ -isysroot$(shell xcrun --show-sdk-path)
 darwin_AR:=$(shell xcrun -f ar)
 darwin_RANLIB:=$(shell xcrun -f ranlib)
 darwin_STRIP:=$(shell xcrun -f strip)
@@ -19,4 +20,11 @@ darwin_LIBTOOL:=$(shell xcrun -f libtool)
 darwin_OTOOL:=$(shell xcrun -f otool)
 darwin_NM:=$(shell xcrun -f nm)
 darwin_INSTALL_NAME_TOOL:=$(shell xcrun -f install_name_tool)
+darwin_DSYMUTIL:=$(shell xcrun -f dsymutil)
+darwin_native_binutils=
 darwin_native_toolchain=
+
+x86_64_darwin_CFLAGS += -arch x86_64
+x86_64_darwin_CXXFLAGS += -arch x86_64
+aarch64_darwin_CFLAGS += -arch arm64
+aarch64_darwin_CXXFLAGS += -arch arm64
diff --git a/depends/hosts/darwin.mk b/depends/hosts/darwin.mk
index 4e58bec74e..ecd45540cf 100644
--- a/depends/hosts/darwin.mk
+++ b/depends/hosts/darwin.mk
@@ -1,12 +1,102 @@
-OSX_MIN_VERSION=10.8
-OSX_SDK_VERSION=10.11
-OSX_SDK=$(SDK_PATH)/MacOSX$(OSX_SDK_VERSION).sdk
-LD64_VERSION=253.9
-darwin_CC=clang -target $(host) -mmacosx-version-min=$(OSX_MIN_VERSION) --sysroot $(OSX_SDK) -mlinker-version=$(LD64_VERSION)
-darwin_CXX=clang++ -target $(host) -mmacosx-version-min=$(OSX_MIN_VERSION) --sysroot $(OSX_SDK) -mlinker-version=$(LD64_VERSION) -stdlib=libc++
+OSX_MIN_VERSION=11.0
+OSX_SDK_VERSION=11.0
+XCODE_VERSION=12.2
+XCODE_BUILD_ID=12B45b
+LD64_VERSION=711
 
-darwin_CFLAGS=-pipe
-darwin_CXXFLAGS=$(darwin_CFLAGS)
+OSX_SDK=$(SDK_PATH)/Xcode-$(XCODE_VERSION)-$(XCODE_BUILD_ID)-extracted-SDK-with-libcxx-headers
+
+darwin_native_binutils=native_cctools
+
+ifeq ($(strip $(FORCE_USE_SYSTEM_CLANG)),)
+# FORCE_USE_SYSTEM_CLANG is empty, so we use our depends-managed, pinned clang
+# from llvm.org
+
+# Clang is a dependency of native_cctools when FORCE_USE_SYSTEM_CLANG is empty
+darwin_native_toolchain=native_cctools
+
+clang_prog=$(build_prefix)/bin/clang
+clangxx_prog=$(clang_prog)++
+llvm_config_prog=$(build_prefix)/bin/llvm-config
+
+else
+# FORCE_USE_SYSTEM_CLANG is non-empty, so we use the clang from the user's
+# system
+
+darwin_native_toolchain=
+
+# We can't just use $(shell command -v clang) because GNU Make handles builtins
+# in a special way and doesn't know that `command` is a POSIX-standard builtin
+# prior to 1af314465e5dfe3e8baa839a32a72e83c04f26ef, first released in v4.2.90.
+# At the time of writing, GNU Make v4.2.1 is still being used in supported
+# distro releases.
+#
+# Source: https://lists.gnu.org/archive/html/bug-make/2017-11/msg00017.html
+clang_prog=$(shell $(SHELL) $(.SHELLFLAGS) "command -v clang")
+clangxx_prog=$(shell $(SHELL) $(.SHELLFLAGS) "command -v clang++")
+llvm_config_prog=$(shell $(SHELL) $(.SHELLFLAGS) "command -v llvm-config")
+
+llvm_lib_dir=$(shell $(llvm_config_prog) --libdir)
+endif
+
+cctools_TOOLS=AR RANLIB STRIP NM LIBTOOL OTOOL INSTALL_NAME_TOOL DSYMUTIL
+
+# Make-only lowercase function
+lc = $(subst A,a,$(subst B,b,$(subst C,c,$(subst D,d,$(subst E,e,$(subst F,f,$(subst G,g,$(subst H,h,$(subst I,i,$(subst J,j,$(subst K,k,$(subst L,l,$(subst M,m,$(subst N,n,$(subst O,o,$(subst P,p,$(subst Q,q,$(subst R,r,$(subst S,s,$(subst T,t,$(subst U,u,$(subst V,v,$(subst W,w,$(subst X,x,$(subst Y,y,$(subst Z,z,$1))))))))))))))))))))))))))
+
+# For well-known tools provided by cctools, make sure that their well-known
+# variable is set to the full path of the tool, just like how AC_PATH_{TOO,PROG}
+# would.
+$(foreach TOOL,$(cctools_TOOLS),$(eval darwin_$(TOOL) = $$(build_prefix)/bin/$$(host)-$(call lc,$(TOOL))))
+
+# Flag explanations:
+#
+#     -mlinker-version
+#
+#         Ensures that modern linker features are enabled. See here for more
+#         details: https://github.com/bitcoin/bitcoin/pull/19407.
+#
+#     -B$(build_prefix)/bin
+#
+#         Explicitly point to our binaries (e.g. cctools) so that they are
+#         ensured to be found and preferred over other possibilities.
+#
+#     -isysroot$(OSX_SDK) -nostdlibinc
+#
+#         Disable default include paths built into the compiler as well as
+#         those normally included for libc and libc++. The only path that
+#         remains implicitly is the clang resource dir.
+#
+#     -iwithsysroot / -iframeworkwithsysroot
+#
+#         Adds the desired paths from the SDK
+#
+
+darwin_CC=env -u C_INCLUDE_PATH -u CPLUS_INCLUDE_PATH \
+              -u OBJC_INCLUDE_PATH -u OBJCPLUS_INCLUDE_PATH -u CPATH \
+              -u LIBRARY_PATH \
+            $(clang_prog) --target=$(host) -mmacosx-version-min=$(OSX_MIN_VERSION) \
+              -B$(build_prefix)/bin -mlinker-version=$(LD64_VERSION) \
+              -isysroot$(OSX_SDK) -nostdlibinc \
+              -iwithsysroot/usr/include -iframeworkwithsysroot/System/Library/Frameworks
+
+darwin_CXX=env -u C_INCLUDE_PATH -u CPLUS_INCLUDE_PATH \
+               -u OBJC_INCLUDE_PATH -u OBJCPLUS_INCLUDE_PATH -u CPATH \
+               -u LIBRARY_PATH \
+             $(clangxx_prog) --target=$(host) -mmacosx-version-min=$(OSX_MIN_VERSION) \
+               -B$(build_prefix)/bin -mlinker-version=$(LD64_VERSION) \
+               -isysroot$(OSX_SDK) -nostdlibinc \
+               -iwithsysroot/usr/include/c++/v1 \
+               -iwithsysroot/usr/include -iframeworkwithsysroot/System/Library/Frameworks
+
+darwin_CFLAGS=-pipe -std=$(C_STANDARD)
+darwin_CXXFLAGS=-pipe -std=$(CXX_STANDARD)
+
+ifneq ($(LTO),)
+darwin_CFLAGS += -flto
+darwin_CXXFLAGS += -flto
+darwin_LDFLAGS += -flto
+endif
 
 darwin_release_CFLAGS=-O2
 darwin_release_CXXFLAGS=$(darwin_release_CFLAGS)
@@ -14,4 +104,4 @@ darwin_release_CXXFLAGS=$(darwin_release_CFLAGS)
 darwin_debug_CFLAGS=-O1
 darwin_debug_CXXFLAGS=$(darwin_debug_CFLAGS)
 
-darwin_native_toolchain=native_cctools
+darwin_cmake_system=Darwin