diff --git a/.jupyter_cache/executed/094517cf9b662d4b071537ec5ac80b62/base.ipynb b/.jupyter_cache/executed/094517cf9b662d4b071537ec5ac80b62/base.ipynb
index e9406f42..5fe69373 100644
--- a/.jupyter_cache/executed/094517cf9b662d4b071537ec5ac80b62/base.ipynb
+++ b/.jupyter_cache/executed/094517cf9b662d4b071537ec5ac80b62/base.ipynb
@@ -135,7 +135,7 @@
        "</svg>\n"
       ],
       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7f99e32f8550>"
+       "<graphviz.graphs.Digraph at 0x7f6ca6712910>"
       ]
      },
      "execution_count": 2,
@@ -168,63 +168,63 @@
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : 2/2 inputs mapped to the graph\n"
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : 2/2 inputs mapped to the graph\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : 2/2 outputs mapped to the graph\n"
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : 2/2 outputs mapped to the graph\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : Pruning the graph with size: V x E = (6, 6)...\n"
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : Pruning the graph with size: V x E = (6, 6)...\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : Finished. Final size: V x E = (6, 6).\n"
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : Finished. Final size: V x E = (6, 6).\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : 2/2 inputs after pruning.\n"
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : 2/2 inputs after pruning.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : 2/2 outputs after pruning.\n"
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : 2/2 outputs after pruning.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : Converting into a flow graph...\n"
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : Converting into a flow graph...\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : Creating a network flow problem...\n"
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : Creating a network flow problem...\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : Preprocess completed.\n"
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : Preprocess completed.\n"
      ]
     },
     {
@@ -235,35 +235,35 @@
       "                                     CVXPY                                     \n",
       "                                     v1.4.3                                    \n",
       "===============================================================================\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Your problem has 86 variables, 20 constraints, and 0 parameters.\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Your problem has 86 variables, 20 constraints, and 0 parameters.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: It is compliant with the following grammars: DCP, DQCP\n"
+      "(CVXPY) Apr 25 10:48:19 AM: It is compliant with the following grammars: DCP, DQCP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
+      "(CVXPY) Apr 25 10:48:19 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:48:19 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: Your problem is compiled with the CPP canonicalization backend.\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Your problem is compiled with the CPP canonicalization backend.\n"
      ]
     },
     {
@@ -273,49 +273,49 @@
       "-------------------------------------------------------------------------------\n",
       "                                  Compilation                                  \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Compiling problem (target solver=SCIP).\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Compiling problem (target solver=SCIP).\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIP\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: Applying reduction Dcp2Cone\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Applying reduction Dcp2Cone\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: Applying reduction CvxAttr2Constr\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Applying reduction CvxAttr2Constr\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: Applying reduction ConeMatrixStuffing\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Applying reduction ConeMatrixStuffing\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: Applying reduction SCIP\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Applying reduction SCIP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: Finished problem compilation (took 2.805e-02 seconds).\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Finished problem compilation (took 3.197e-02 seconds).\n"
      ]
     },
     {
@@ -325,7 +325,7 @@
       "-------------------------------------------------------------------------------\n",
       "                                Numerical solver                               \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Invoking solver SCIP  to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Invoking solver SCIP  to obtain a solution.\n"
      ]
     },
     {
@@ -334,9 +334,7 @@
      "text": [
       "-------------------------------------------------------------------------------\n",
       "                                    Summary                                    \n",
-      "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Problem status: optimal\n",
-      "presolving:\n",
+      "-------------------------------------------------------------------------------presolving:\n",
       "(round 1, fast)       36 del vars, 95 del conss, 0 add conss, 48 chg bounds, 1 chg sides, 23 chg coeffs, 0 upgd conss, 0 impls, 28 clqs\n",
       "(round 2, fast)       54 del vars, 129 del conss, 0 add conss, 52 chg bounds, 9 chg sides, 31 chg coeffs, 0 upgd conss, 0 impls, 20 clqs\n",
       "(round 3, fast)       63 del vars, 145 del conss, 0 add conss, 52 chg bounds, 11 chg sides, 33 chg coeffs, 0 upgd conss, 0 impls, 18 clqs\n",
@@ -367,49 +365,50 @@
       "Presolving Time: 0.00\n",
       "\n",
       " time | node  | left  |LP iter|LP it/n|mem/heur|mdpt |vars |cons |rows |cuts |sepa|confs|strbr|  dualbound   | primalbound  |  gap   | compl. \n",
-      "p 0.0s|     1 |     0 |     1 |     - |  clique|   0 |  27 |  45 |  42 |   0 |  0 |   0 |   0 |-3.500000e+00 | 1.000000e-01 |    Inf | unknown\n",
-      "p 0.0s|     1 |     0 |     1 |     - |   locks|   0 |  27 |  45 |  42 |   0 |  0 |   0 |   0 |-3.500000e+00 |-6.000000e-01 | 483.33%| unknown\n",
-      "p 0.0s|     1 |     0 |     1 |     - | vbounds|   0 |  27 |  46 |  42 |   0 |  0 |   1 |   0 |-3.500000e+00 |-1.600000e+00 | 118.75%| unknown\n",
-      "p 0.0s|     1 |     0 |     1 |     - | vbounds|   0 |  27 |  48 |  42 |   0 |  0 |   3 |   0 |-3.500000e+00 |-3.200000e+00 |   9.37%| unknown\n",
-      "  0.0s|     1 |     0 |    16 |     - |  1789k |   0 |  27 |  29 |  42 |   0 |  0 |   9 |   0 |-3.300000e+00 |-3.200000e+00 |   3.13%| unknown\n",
-      "  0.0s|     1 |     0 |    21 |     - |  1810k |   0 |  27 |  29 |  45 |   3 |  1 |   9 |   0 |-3.300000e+00 |-3.200000e+00 |   3.13%| unknown\n",
-      "r 0.0s|     1 |     0 |    21 |     - |rounding|   0 |  27 |  29 |  45 |   3 |  1 |   9 |   0 |-3.300000e+00 |-3.300000e+00 |   0.00%| unknown\n",
-      "  0.0s|     1 |     0 |    21 |     - |  1810k |   0 |  27 |  29 |  45 |   3 |  1 |   9 |   0 |-3.300000e+00 |-3.300000e+00 |   0.00%| unknown\n",
+      "p 0.0s|     1 |     0 |     0 |     - |  clique|   0 |  27 |  45 |  42 |   0 |  0 |   0 |   0 |-3.500000e+00 | 1.000000e-01 |    Inf | unknown\n",
+      "p 0.0s|     1 |     0 |     0 |     - |   locks|   0 |  27 |  45 |  42 |   0 |  0 |   0 |   0 |-3.500000e+00 |-6.000000e-01 | 483.33%| unknown\n",
+      "p 0.0s|     1 |     0 |     0 |     - | vbounds|   0 |  27 |  45 |  42 |   0 |  0 |   0 |   0 |-3.500000e+00 |-1.600000e+00 | 118.75%| unknown\n",
+      "p 0.0s|     1 |     0 |     0 |     - | vbounds|   0 |  27 |  46 |  42 |   0 |  0 |   1 |   0 |-3.500000e+00 |-3.200000e+00 |   9.37%| unknown\n",
+      "  0.0s|     1 |     0 |    14 |     - |  1786k |   0 |  27 |  29 |  42 |   0 |  0 |   7 |   0 |-3.300000e+00 |-3.200000e+00 |   3.13%| unknown\n",
+      "r 0.0s|     1 |     0 |    14 |     - |rounding|   0 |  27 |  29 |  42 |   0 |  0 |   7 |   0 |-3.300000e+00 |-3.300000e+00 |   0.00%| unknown\n",
+      "  0.0s|     1 |     0 |    14 |     - |  1786k |   0 |  27 |  29 |  42 |   0 |  0 |   7 |   0 |-3.300000e+00 |-3.300000e+00 |   0.00%| unknown\n",
       "\n",
       "SCIP Status        : problem is solved [optimal solution found]\n",
       "Solving Time (sec) : 0.00\n",
       "Solving Nodes      : 1\n",
       "Primal Bound       : -3.30000000000000e+00 (5 solutions)\n",
       "Dual Bound         : -3.30000000000000e+00\n",
-      "Gap                : 0.00 %\n"
+      "Gap                : 0.00 %\n",
+      "\n",
+      "(CVXPY) Apr 25 10:48:19 AM: Problem status: optimal\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: Optimal value: 7.000e-01\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Optimal value: 7.000e-01\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: Compilation took 2.805e-02 seconds\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Compilation took 3.197e-02 seconds\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: Solver (including time spent in interface) took 1.459e-02 seconds\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Solver (including time spent in interface) took 1.419e-02 seconds\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : Finished in 0.07 s.\n"
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : Finished in 0.07 s.\n"
      ]
     }
    ],
@@ -551,7 +550,7 @@
        "</svg>\n"
       ],
       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7f99e2fedbd0>"
+       "<graphviz.graphs.Digraph at 0x7f6ca6799a10>"
       ]
      },
      "execution_count": 5,
@@ -601,32 +600,32 @@
        "  <tbody>\n",
        "    <tr>\n",
        "      <th>0</th>\n",
-       "      <td>I2</td>\n",
+       "      <td>M2</td>\n",
        "      <td>1.0</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>1</th>\n",
-       "      <td>M1</td>\n",
+       "      <td>I1</td>\n",
        "      <td>1.0</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>2</th>\n",
-       "      <td>N1</td>\n",
-       "      <td>0.0</td>\n",
+       "      <td>N2</td>\n",
+       "      <td>-1.0</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>3</th>\n",
-       "      <td>N2</td>\n",
-       "      <td>-1.0</td>\n",
+       "      <td>N1</td>\n",
+       "      <td>0.0</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>4</th>\n",
-       "      <td>I1</td>\n",
+       "      <td>M1</td>\n",
        "      <td>1.0</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>5</th>\n",
-       "      <td>M2</td>\n",
+       "      <td>I2</td>\n",
        "      <td>1.0</td>\n",
        "    </tr>\n",
        "    <tr>\n",
@@ -655,12 +654,12 @@
       ],
       "text/plain": [
        "          V  value\n",
-       "0        I2    1.0\n",
-       "1        M1    1.0\n",
-       "2        N1    0.0\n",
-       "3        N2   -1.0\n",
-       "4        I1    1.0\n",
-       "5        M2    1.0\n",
+       "0        M2    1.0\n",
+       "1        I1    1.0\n",
+       "2        N2   -1.0\n",
+       "3        N1    0.0\n",
+       "4        M1    1.0\n",
+       "5        I2    1.0\n",
        "6        _s    1.0\n",
        "7  _pert_c0    1.0\n",
        "8  _meas_c0    0.0\n",
@@ -955,7 +954,7 @@
        "</svg>\n"
       ],
       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7f99e0e2fbd0>"
+       "<graphviz.graphs.Digraph at 0x7f6ca46e3e50>"
       ]
      },
      "execution_count": 8,
diff --git a/.jupyter_cache/executed/25bf812442150df0e2133bc8edc87bd9/base.ipynb b/.jupyter_cache/executed/25bf812442150df0e2133bc8edc87bd9/base.ipynb
index 7fc1b7e1..cbd50efb 100644
--- a/.jupyter_cache/executed/25bf812442150df0e2133bc8edc87bd9/base.ipynb
+++ b/.jupyter_cache/executed/25bf812442150df0e2133bc8edc87bd9/base.ipynb
@@ -200,7 +200,7 @@
        "</svg>\n"
       ],
       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7f85e5fe5550>"
+       "<graphviz.graphs.Digraph at 0x7f91d8b83b10>"
       ]
      },
      "execution_count": 5,
diff --git a/.jupyter_cache/executed/43db6d99b10aae7002b43157110f8d59/base.ipynb b/.jupyter_cache/executed/43db6d99b10aae7002b43157110f8d59/base.ipynb
index f8b21b86..f59d419b 100644
--- a/.jupyter_cache/executed/43db6d99b10aae7002b43157110f8d59/base.ipynb
+++ b/.jupyter_cache/executed/43db6d99b10aae7002b43157110f8d59/base.ipynb
@@ -42,7 +42,7 @@
        "                <td><strong>Name</strong></td><td>Biomass Objective Function with GAM</td>\n",
        "            </tr><tr>\n",
        "                <td><strong>Memory address</strong></td>\n",
-       "                <td>0x7f4ff9f4e350</td>\n",
+       "                <td>0x7fefbc1edfd0</td>\n",
        "            </tr><tr>\n",
        "                <td><strong>Stoichiometry</strong></td>\n",
        "                <td>\n",
@@ -60,7 +60,7 @@
        "        "
       ],
       "text/plain": [
-       "<Reaction Biomass_Ecoli_core at 0x7f4ff9f4e350>"
+       "<Reaction Biomass_Ecoli_core at 0x7fefbc1edfd0>"
       ]
      },
      "execution_count": 2,
@@ -83,7 +83,7 @@
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "<Solution 0.874 at 0x7f4ffa0b3750>\n"
+      "<Solution 0.874 at 0x7fefbc0acf50>\n"
      ]
     }
    ],
@@ -210,35 +210,35 @@
      "output_type": "stream",
      "text": [
       "Warning: node 'acald_c', graph '%3' size too small for label\n",
-      "Warning: node 'nad_c', graph '%3' size too small for label\n",
       "Warning: node 'coa_c', graph '%3' size too small for label\n",
+      "Warning: node 'nad_c', graph '%3' size too small for label\n",
       "Warning: node 'accoa_c', graph '%3' size too small for label\n",
       "Warning: node 'nadh_c', graph '%3' size too small for label\n",
       "Warning: node 'acald_e', graph '%3' size too small for label\n",
       "Warning: node 'atp_c', graph '%3' size too small for label\n",
-      "Warning: node 'adp_c', graph '%3' size too small for label\n",
       "Warning: node 'actp_c', graph '%3' size too small for label\n",
+      "Warning: node 'adp_c', graph '%3' size too small for label\n",
       "Warning: node 'acon_C_c', graph '%3' size too small for label\n",
       "Warning: node 'h2o_c', graph '%3' size too small for label\n",
       "Warning: node 'icit_c', graph '%3' size too small for label\n",
       "Warning: node 'amp_c', graph '%3' size too small for label\n",
       "Warning: node 'akg_c', graph '%3' size too small for label\n",
-      "Warning: node 'succoa_c', graph '%3' size too small for label\n",
       "Warning: node 'co2_c', graph '%3' size too small for label\n",
+      "Warning: node 'succoa_c', graph '%3' size too small for label\n",
       "Warning: node 'akg_e', graph '%3' size too small for label\n",
       "Warning: node 'etoh_c', graph '%3' size too small for label\n",
-      "Warning: node 'r5p_c', graph '%3' size too small for label\n",
-      "Warning: node '3pg_c', graph '%3' size too small for label\n",
-      "Warning: node 'gln__L_c', graph '%3' size too small for label\n",
+      "Warning: node 'nadph_c', graph '%3' size too small for label\n",
+      "Warning: node 'g3p_c', graph '%3' size too small for label\n",
       "Warning: node 'glu__L_c', graph '%3' size too small for label\n",
-      "Warning: node 'f6p_c', graph '%3' size too small for label\n",
-      "Warning: node 'pyr_c', graph '%3' size too small for label\n",
       "Warning: node 'oaa_c', graph '%3' size too small for label\n",
-      "Warning: node 'pep_c', graph '%3' size too small for label\n",
-      "Warning: node 'nadph_c', graph '%3' size too small for label\n",
+      "Warning: node 'pyr_c', graph '%3' size too small for label\n",
       "Warning: node 'e4p_c', graph '%3' size too small for label\n",
-      "Warning: node 'g3p_c', graph '%3' size too small for label\n",
+      "Warning: node 'r5p_c', graph '%3' size too small for label\n",
+      "Warning: node 'gln__L_c', graph '%3' size too small for label\n",
       "Warning: node 'g6p_c', graph '%3' size too small for label\n",
+      "Warning: node 'pep_c', graph '%3' size too small for label\n",
+      "Warning: node 'f6p_c', graph '%3' size too small for label\n",
+      "Warning: node '3pg_c', graph '%3' size too small for label\n",
       "Warning: node 'nadp_c', graph '%3' size too small for label\n",
       "Warning: node 'co2_e', graph '%3' size too small for label\n",
       "Warning: node 'q8h2_c', graph '%3' size too small for label\n",
@@ -280,2805 +280,2805 @@
        "<!-- Generated by graphviz version 2.43.0 (0)\n",
        " -->\n",
        "<!-- Title: %3 Pages: 1 -->\n",
-       "<svg width=\"775pt\" height=\"706pt\"\n",
-       " viewBox=\"0.00 0.00 775.00 706.00\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">\n",
-       "<g id=\"graph0\" class=\"graph\" transform=\"scale(1 1) rotate(0) translate(4 702)\">\n",
+       "<svg width=\"2099pt\" height=\"2511pt\"\n",
+       " viewBox=\"0.00 0.00 2099.00 2511.00\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">\n",
+       "<g id=\"graph0\" class=\"graph\" transform=\"scale(1 1) rotate(0) translate(4 2507)\">\n",
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       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7f4fe8c09850>"
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diff --git a/.jupyter_cache/executed/4b6c60c42f20e0738189935b8e87f5a1/base.ipynb b/.jupyter_cache/executed/4b6c60c42f20e0738189935b8e87f5a1/base.ipynb
index 03bf4ad5..fe7943b3 100644
--- a/.jupyter_cache/executed/4b6c60c42f20e0738189935b8e87f5a1/base.ipynb
+++ b/.jupyter_cache/executed/4b6c60c42f20e0738189935b8e87f5a1/base.ipynb
@@ -51,35 +51,35 @@
       "                                     CVXPY                                     \n",
       "                                     v1.4.3                                    \n",
       "===============================================================================\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Your problem has 5 variables, 2 constraints, and 0 parameters.\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Your problem has 5 variables, 2 constraints, and 0 parameters.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: It is compliant with the following grammars: DCP, DQCP\n"
+      "(CVXPY) Apr 25 10:46:24 AM: It is compliant with the following grammars: DCP, DQCP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
+      "(CVXPY) Apr 25 10:46:24 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:46:24 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: Your problem is compiled with the CPP canonicalization backend.\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Your problem is compiled with the CPP canonicalization backend.\n"
      ]
     },
     {
@@ -89,49 +89,49 @@
       "-------------------------------------------------------------------------------\n",
       "                                  Compilation                                  \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Compiling problem (target solver=OSQP).\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Compiling problem (target solver=OSQP).\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: Reduction chain: CvxAttr2Constr -> Qp2SymbolicQp -> QpMatrixStuffing -> OSQP\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Reduction chain: CvxAttr2Constr -> Qp2SymbolicQp -> QpMatrixStuffing -> OSQP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: Applying reduction CvxAttr2Constr\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Applying reduction CvxAttr2Constr\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: Applying reduction Qp2SymbolicQp\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Applying reduction Qp2SymbolicQp\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: Applying reduction QpMatrixStuffing\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Applying reduction QpMatrixStuffing\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: Applying reduction OSQP\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Applying reduction OSQP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: Finished problem compilation (took 9.753e-03 seconds).\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Finished problem compilation (took 9.047e-03 seconds).\n"
      ]
     },
     {
@@ -141,7 +141,7 @@
       "-------------------------------------------------------------------------------\n",
       "                                Numerical solver                               \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Invoking solver OSQP  to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Invoking solver OSQP  to obtain a solution.\n"
      ]
     },
     {
@@ -165,42 +165,42 @@
       "          warm start: on, polish: on, time_limit: off\n",
       "\n",
       "iter   objective    pri res    dua res    rho        time\n",
-      "   1  -5.2220e+00   3.68e+00   1.70e+02   1.00e-01   4.35e-05s\n",
-      " 150   6.9994e-01   1.96e-05   7.82e-06   4.77e+00   9.17e-05s\n",
-      "plsh   7.0000e-01   1.95e-30   0.00e+00   --------   1.20e-04s\n",
+      "   1  -5.2220e+00   3.68e+00   1.70e+02   1.00e-01   4.43e-05s\n",
+      " 150   6.9994e-01   1.96e-05   7.82e-06   4.77e+00   9.01e-05s\n",
+      "plsh   7.0000e-01   1.95e-30   0.00e+00   --------   1.23e-04s\n",
       "\n",
       "status:               solved\n",
       "solution polish:      successful\n",
       "number of iterations: 150\n",
       "optimal objective:    0.7000\n",
-      "run time:             1.20e-04s\n",
+      "run time:             1.23e-04s\n",
       "optimal rho estimate: 9.81e+00\n",
       "\n",
       "-------------------------------------------------------------------------------\n",
       "                                    Summary                                    \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Problem status: optimal\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Problem status: optimal\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: Optimal value: -3.000e-01\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Optimal value: -3.000e-01\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: Compilation took 9.753e-03 seconds\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Compilation took 9.047e-03 seconds\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: Solver (including time spent in interface) took 2.524e-03 seconds\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Solver (including time spent in interface) took 1.582e-03 seconds\n"
      ]
     }
    ],
diff --git a/.jupyter_cache/executed/517c8075025ade78e95139e2b291eb2c/base.ipynb b/.jupyter_cache/executed/517c8075025ade78e95139e2b291eb2c/base.ipynb
index 7e6bb587..6cd7e148 100644
--- a/.jupyter_cache/executed/517c8075025ade78e95139e2b291eb2c/base.ipynb
+++ b/.jupyter_cache/executed/517c8075025ade78e95139e2b291eb2c/base.ipynb
@@ -135,7 +135,7 @@
        "</svg>\n"
       ],
       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7f7b11a05090>"
+       "<graphviz.graphs.Digraph at 0x7f7f761fc1d0>"
       ]
      },
      "execution_count": 2,
@@ -286,7 +286,7 @@
        "</svg>\n"
       ],
       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7f7b13fa3c90>"
+       "<graphviz.graphs.Digraph at 0x7f7f787e3d90>"
       ]
      },
      "execution_count": 3,
@@ -386,35 +386,35 @@
       "                                     CVXPY                                     \n",
       "                                     v1.4.3                                    \n",
       "===============================================================================\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Your problem has 20 variables, 5 constraints, and 0 parameters.\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Your problem has 20 variables, 5 constraints, and 0 parameters.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: It is compliant with the following grammars: DCP, DQCP\n"
+      "(CVXPY) Apr 25 10:46:33 AM: It is compliant with the following grammars: DCP, DQCP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
+      "(CVXPY) Apr 25 10:46:33 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:46:33 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: Your problem is compiled with the CPP canonicalization backend.\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Your problem is compiled with the CPP canonicalization backend.\n"
      ]
     },
     {
@@ -424,49 +424,49 @@
       "-------------------------------------------------------------------------------\n",
       "                                  Compilation                                  \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Compiling problem (target solver=SCIP).\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Compiling problem (target solver=SCIP).\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIP\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: Applying reduction Dcp2Cone\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Applying reduction Dcp2Cone\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: Applying reduction CvxAttr2Constr\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Applying reduction CvxAttr2Constr\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: Applying reduction ConeMatrixStuffing\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Applying reduction ConeMatrixStuffing\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: Applying reduction SCIP\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Applying reduction SCIP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: Finished problem compilation (took 1.412e-02 seconds).\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Finished problem compilation (took 1.440e-02 seconds).\n"
      ]
     },
     {
@@ -476,7 +476,7 @@
       "-------------------------------------------------------------------------------\n",
       "                                Numerical solver                               \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Invoking solver SCIP  to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Invoking solver SCIP  to obtain a solution.\n"
      ]
     },
     {
@@ -486,7 +486,13 @@
       "-------------------------------------------------------------------------------\n",
       "                                    Summary                                    \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Problem status: optimal\n",
+      "(CVXPY) Apr 25 10:46:33 AM: Problem status: optimal\n"
+     ]
+    },
+    {
+     "name": "stdout",
+     "output_type": "stream",
+     "text": [
       "presolving:\n",
       "   (0.0s) symmetry computation started: requiring (bin +, int +, cont +), (fixed: bin -, int -, cont -)\n",
       "   (0.0s) no symmetry present (symcode time: 0.00)\n",
@@ -506,28 +512,22 @@
       "Solving Nodes      : 1\n",
       "Primal Bound       : -1.90000000000000e+02 (1 solutions)\n",
       "Dual Bound         : -1.90000000000000e+02\n",
-      "Gap                : 0.00 %\n"
-     ]
-    },
-    {
-     "name": "stdout",
-     "output_type": "stream",
-     "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: Optimal value: -1.900e+02\n"
+      "Gap                : 0.00 %\n",
+      "(CVXPY) Apr 25 10:46:33 AM: Optimal value: -1.900e+02\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: Compilation took 1.412e-02 seconds\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Compilation took 1.440e-02 seconds\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: Solver (including time spent in interface) took 6.421e-03 seconds\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Solver (including time spent in interface) took 6.373e-03 seconds\n"
      ]
     },
     {
diff --git a/.jupyter_cache/executed/5d6f361d9e37c70dcbca3b8f4d6e510d/base.ipynb b/.jupyter_cache/executed/5d6f361d9e37c70dcbca3b8f4d6e510d/base.ipynb
index f353c42f..451a196b 100644
--- a/.jupyter_cache/executed/5d6f361d9e37c70dcbca3b8f4d6e510d/base.ipynb
+++ b/.jupyter_cache/executed/5d6f361d9e37c70dcbca3b8f4d6e510d/base.ipynb
@@ -93,7 +93,7 @@
       "Solver claims optimal solution for feasible problem.\n",
       "Applying the solution.\n",
       "Applied solution is primal feasible.\n",
-      "Search 1.4e-02s, solve 1.9e-02s, overhead 31%.\n",
+      "Search 1.4e-02s, solve 1.9e-02s, overhead 34%.\n",
       "=============[ PICOS ]=============\n"
      ]
     }
diff --git a/.jupyter_cache/executed/5e0662f0c002e3e51fbb7e377567e03e/base.ipynb b/.jupyter_cache/executed/5e0662f0c002e3e51fbb7e377567e03e/base.ipynb
index 19029588..75d2cc58 100644
--- a/.jupyter_cache/executed/5e0662f0c002e3e51fbb7e377567e03e/base.ipynb
+++ b/.jupyter_cache/executed/5e0662f0c002e3e51fbb7e377567e03e/base.ipynb
@@ -96,7 +96,7 @@
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@@ -190,7 +190,7 @@
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       ],
       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7fd7fcf00390>"
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@@ -286,7 +286,7 @@
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-       "<graphviz.graphs.Digraph at 0x7fd7fd1c9810>"
+       "<graphviz.graphs.Digraph at 0x7f50ecf4ddd0>"
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@@ -514,7 +514,7 @@
        "</svg>\n"
       ],
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-       "<graphviz.graphs.Digraph at 0x7fd7fcd5a390>"
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-       "<title>A&#45;&gt;e_0_center</title>\n",
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        "</g>\n",
-       "<!-- B -->\n",
+       "<!-- A -->\n",
        "<g id=\"node2\" class=\"node\">\n",
-       "<title>B</title>\n",
+       "<title>A</title>\n",
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-       "<text text-anchor=\"middle\" x=\"72\" y=\"-244.3\" font-family=\"Times,serif\" font-size=\"14.00\">B</text>\n",
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        "</g>\n",
-       "<!-- B&#45;&gt;e_0_center -->\n",
+       "<!-- A&#45;&gt;e_0_center -->\n",
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index a4040bae..8cce109c 100644
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index b2ed73d6..d95ad2dc 100644
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+++ b/.jupyter_cache/executed/9207a79194e6c46831386d8e051393f9/base.ipynb
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       "Warning: node 'coa_c', graph '%3' size too small for label\n",
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-      "Warning: node 'succoa_c', graph '%3' size too small for label\n",
       "Warning: node 'co2_c', graph '%3' size too small for label\n",
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-      "Warning: node 'glu__L_c', graph '%3' size too small for label\n",
-      "Warning: node 'pep_c', graph '%3' size too small for label\n",
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+      "Warning: node 'f6p_c', graph '%3' size too small for label\n",
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+      "Warning: node 'r5p_c', graph '%3' size too small for label\n",
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-      "Warning: node 'f6p_c', graph '%3' size too small for label\n",
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-      "Warning: node 'r5p_c', graph '%3' size too small for label\n",
-      "Warning: node 'gln__L_c', graph '%3' size too small for label\n",
+      "Warning: node 'glu__L_c', graph '%3' size too small for label\n",
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-       "<!-- g6p_c -->\n",
+       "<!-- r5p_c -->\n",
+       "<g id=\"node40\" class=\"node\">\n",
+       "<title>r5p_c</title>\n",
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+       "<!-- ru5p__D_c -->\n",
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+       "<!-- r5p_c&#45;&gt;ru5p__D_c -->\n",
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diff --git a/.jupyter_cache/executed/a6f4873eacabb963a97b021f7c0cbd92/base.ipynb b/.jupyter_cache/executed/a6f4873eacabb963a97b021f7c0cbd92/base.ipynb
index daa74c69..12d1f3df 100644
--- a/.jupyter_cache/executed/a6f4873eacabb963a97b021f7c0cbd92/base.ipynb
+++ b/.jupyter_cache/executed/a6f4873eacabb963a97b021f7c0cbd92/base.ipynb
@@ -45,7 +45,7 @@
     {
      "data": {
       "text/plain": [
-       "<corneto.backend._cvxpy_backend.CvxpyBackend at 0x7fcc1ca007d0>"
+       "<corneto.backend._cvxpy_backend.CvxpyBackend at 0x7f086c7f8e50>"
       ]
      },
      "execution_count": 2,
@@ -99,7 +99,7 @@
     {
      "data": {
       "text/plain": [
-       "<corneto.backend._base.ProblemDef at 0x7fcbeded6210>"
+       "<corneto.backend._base.ProblemDef at 0x7f087c7beed0>"
       ]
      },
      "execution_count": 4,
@@ -198,35 +198,35 @@
       "                                     CVXPY                                     \n",
       "                                     v1.4.3                                    \n",
       "===============================================================================\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Your problem has 50 variables, 1 constraints, and 0 parameters.\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Your problem has 50 variables, 1 constraints, and 0 parameters.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: It is compliant with the following grammars: DCP, DQCP\n"
+      "(CVXPY) Apr 25 10:46:32 AM: It is compliant with the following grammars: DCP, DQCP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
+      "(CVXPY) Apr 25 10:46:32 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:46:32 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Your problem is compiled with the CPP canonicalization backend.\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Your problem is compiled with the CPP canonicalization backend.\n"
      ]
     },
     {
@@ -236,56 +236,56 @@
       "-------------------------------------------------------------------------------\n",
       "                                  Compilation                                  \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Compiling problem (target solver=SCIP).\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Compiling problem (target solver=SCIP).\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Reduction chain: FlipObjective -> Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIP\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Reduction chain: FlipObjective -> Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Applying reduction FlipObjective\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Applying reduction FlipObjective\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Applying reduction Dcp2Cone\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Applying reduction Dcp2Cone\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Applying reduction CvxAttr2Constr\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Applying reduction CvxAttr2Constr\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Applying reduction ConeMatrixStuffing\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Applying reduction ConeMatrixStuffing\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Applying reduction SCIP\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Applying reduction SCIP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Finished problem compilation (took 8.441e-03 seconds).\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Finished problem compilation (took 8.368e-03 seconds).\n"
      ]
     },
     {
@@ -295,7 +295,7 @@
       "-------------------------------------------------------------------------------\n",
       "                                Numerical solver                               \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Invoking solver SCIP  to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Invoking solver SCIP  to obtain a solution.\n"
      ]
     },
     {
@@ -304,7 +304,9 @@
      "text": [
       "-------------------------------------------------------------------------------\n",
       "                                    Summary                                    \n",
-      "-------------------------------------------------------------------------------feasible solution found by trivial heuristic after 0.0 seconds, objective value -6.000000e+02\n",
+      "-------------------------------------------------------------------------------\n",
+      "(CVXPY) Apr 25 10:46:32 AM: Problem status: optimal\n",
+      "feasible solution found by trivial heuristic after 0.0 seconds, objective value -6.000000e+02\n",
       "presolving:\n",
       "(round 1, fast)       4 del vars, 0 del conss, 0 add conss, 0 chg bounds, 0 chg sides, 0 chg coeffs, 0 upgd conss, 0 impls, 0 clqs\n",
       "(round 2, exhaustive) 4 del vars, 0 del conss, 0 add conss, 0 chg bounds, 0 chg sides, 0 chg coeffs, 1 upgd conss, 0 impls, 0 clqs\n",
@@ -320,30 +322,28 @@
       "Solving Nodes      : 0\n",
       "Primal Bound       : -7.53400000000000e+03 (3 solutions)\n",
       "Dual Bound         : -7.53400000000000e+03\n",
-      "Gap                : 0.00 %\n",
-      "\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Problem status: optimal\n"
+      "Gap                : 0.00 %\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Optimal value: 7.534e+03\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Optimal value: 7.534e+03\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Compilation took 8.441e-03 seconds\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Compilation took 8.368e-03 seconds\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Solver (including time spent in interface) took 3.624e-03 seconds\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Solver (including time spent in interface) took 3.592e-03 seconds\n"
      ]
     },
     {
diff --git a/.jupyter_cache/executed/aa636f5a6eecef6aa2002893edcd864a/base.ipynb b/.jupyter_cache/executed/aa636f5a6eecef6aa2002893edcd864a/base.ipynb
index de69c079..69e10ee4 100644
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index 65cda87b..a1e1302f 100644
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index 4c35b012..49f02f39 100644
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-       "21.2781776291676"
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-      "Warning: node '3092', graph '%3' size too small for label\n",
-      "Warning: node '1748', graph '%3' size too small for label\n"
+      "Warning: node '3066', graph '%3' size too small for label\n",
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diff --git a/.jupyter_cache/executed/eacafec4a2dc14df477fd155cfe3cc73/base.ipynb b/.jupyter_cache/executed/eacafec4a2dc14df477fd155cfe3cc73/base.ipynb
index 12b41bfc..c9390f76 100644
--- a/.jupyter_cache/executed/eacafec4a2dc14df477fd155cfe3cc73/base.ipynb
+++ b/.jupyter_cache/executed/eacafec4a2dc14df477fd155cfe3cc73/base.ipynb
@@ -182,35 +182,35 @@
       "                                     CVXPY                                     \n",
       "                                     v1.4.3                                    \n",
       "===============================================================================\n",
-      "(CVXPY) Apr 25 10:40:58 AM: Your problem has 310 variables, 7 constraints, and 0 parameters.\n"
+      "(CVXPY) Apr 25 10:47:26 AM: Your problem has 310 variables, 7 constraints, and 0 parameters.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:58 AM: It is compliant with the following grammars: DCP, DQCP\n"
+      "(CVXPY) Apr 25 10:47:26 AM: It is compliant with the following grammars: DCP, DQCP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:58 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
+      "(CVXPY) Apr 25 10:47:26 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:58 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:47:26 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:58 AM: Your problem is compiled with the CPP canonicalization backend.\n"
+      "(CVXPY) Apr 25 10:47:26 AM: Your problem is compiled with the CPP canonicalization backend.\n"
      ]
     },
     {
@@ -220,49 +220,49 @@
       "-------------------------------------------------------------------------------\n",
       "                                  Compilation                                  \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:58 AM: Compiling problem (target solver=SCIPY).\n"
+      "(CVXPY) Apr 25 10:47:26 AM: Compiling problem (target solver=SCIPY).\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:58 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIPY\n"
+      "(CVXPY) Apr 25 10:47:26 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIPY\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:58 AM: Applying reduction Dcp2Cone\n"
+      "(CVXPY) Apr 25 10:47:26 AM: Applying reduction Dcp2Cone\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:58 AM: Applying reduction CvxAttr2Constr\n"
+      "(CVXPY) Apr 25 10:47:26 AM: Applying reduction CvxAttr2Constr\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:58 AM: Applying reduction ConeMatrixStuffing\n"
+      "(CVXPY) Apr 25 10:47:26 AM: Applying reduction ConeMatrixStuffing\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:58 AM: Applying reduction SCIPY\n"
+      "(CVXPY) Apr 25 10:47:26 AM: Applying reduction SCIPY\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:58 AM: Finished problem compilation (took 1.355e-02 seconds).\n"
+      "(CVXPY) Apr 25 10:47:26 AM: Finished problem compilation (took 1.438e-02 seconds).\n"
      ]
     },
     {
@@ -272,7 +272,7 @@
       "-------------------------------------------------------------------------------\n",
       "                                Numerical solver                               \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:58 AM: Invoking solver SCIPY  to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:47:26 AM: Invoking solver SCIPY  to obtain a solution.\n"
      ]
     },
     {
@@ -283,28 +283,28 @@
       "-------------------------------------------------------------------------------\n",
       "                                    Summary                                    \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Problem status: optimal\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Problem status: optimal\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: Optimal value: 4.100e+01\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Optimal value: 4.100e+01\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: Compilation took 1.355e-02 seconds\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Compilation took 1.438e-02 seconds\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: Solver (including time spent in interface) took 3.391e+01 seconds\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Solver (including time spent in interface) took 3.394e+01 seconds\n"
      ]
     },
     {
@@ -518,7 +518,7 @@
        "</svg>\n"
       ],
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-       "<graphviz.graphs.Digraph at 0x7f51a9ea9e10>"
+       "<graphviz.graphs.Digraph at 0x7fe7822d6090>"
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      "execution_count": 6,
@@ -567,35 +567,35 @@
       "                                     CVXPY                                     \n",
       "                                     v1.4.3                                    \n",
       "===============================================================================\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Your problem has 670 variables, 17 constraints, and 0 parameters.\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Your problem has 670 variables, 17 constraints, and 0 parameters.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: It is compliant with the following grammars: DCP, DQCP\n"
+      "(CVXPY) Apr 25 10:48:00 AM: It is compliant with the following grammars: DCP, DQCP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
+      "(CVXPY) Apr 25 10:48:00 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:48:00 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: Your problem is compiled with the CPP canonicalization backend.\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Your problem is compiled with the CPP canonicalization backend.\n"
      ]
     },
     {
@@ -605,49 +605,49 @@
       "-------------------------------------------------------------------------------\n",
       "                                  Compilation                                  \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Compiling problem (target solver=SCIPY).\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Compiling problem (target solver=SCIPY).\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIPY\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIPY\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: Applying reduction Dcp2Cone\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Applying reduction Dcp2Cone\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: Applying reduction CvxAttr2Constr\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Applying reduction CvxAttr2Constr\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: Applying reduction ConeMatrixStuffing\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Applying reduction ConeMatrixStuffing\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: Applying reduction SCIPY\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Applying reduction SCIPY\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: Finished problem compilation (took 2.558e-02 seconds).\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Finished problem compilation (took 2.385e-02 seconds).\n"
      ]
     },
     {
@@ -657,7 +657,7 @@
       "-------------------------------------------------------------------------------\n",
       "                                Numerical solver                               \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Invoking solver SCIPY  to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Invoking solver SCIPY  to obtain a solution.\n"
      ]
     },
     {
@@ -668,28 +668,28 @@
       "-------------------------------------------------------------------------------\n",
       "                                    Summary                                    \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:49 AM: Problem status: optimal\n"
+      "(CVXPY) Apr 25 10:48:17 AM: Problem status: optimal\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:49 AM: Optimal value: 4.100e+01\n"
+      "(CVXPY) Apr 25 10:48:17 AM: Optimal value: 4.100e+01\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:49 AM: Compilation took 2.558e-02 seconds\n"
+      "(CVXPY) Apr 25 10:48:17 AM: Compilation took 2.385e-02 seconds\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:49 AM: Solver (including time spent in interface) took 1.722e+01 seconds\n"
+      "(CVXPY) Apr 25 10:48:17 AM: Solver (including time spent in interface) took 1.726e+01 seconds\n"
      ]
     },
     {
@@ -888,7 +888,7 @@
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-       "<graphviz.graphs.Digraph at 0x7f51c813ac10>"
+       "<graphviz.graphs.Digraph at 0x7fe782117a90>"
       ]
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      "execution_count": 8,
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+</g>
+<!-- coa_c -->
+<g id="node2" class="node">
+<title>coa_c</title>
+<ellipse fill="none" stroke="black" cx="853.92" cy="-1209.28" rx="18" ry="18"/>
+<text text-anchor="middle" x="853.92" y="-1205.58" font-family="Times,serif" font-size="14.00">coa_c</text>
+</g>
+<!-- coa_c&#45;&gt;e_0_center -->
+<g id="edge2" class="edge">
+<title>coa_c&#45;&gt;e_0_center</title>
+<path fill="none" stroke="black" d="M870.88,-1216.47C896.39,-1227.22 946.2,-1247.96 989.06,-1264.25 1033.49,-1281.14 1088.21,-1299.66 1102.71,-1304.54"/>
+</g>
+<!-- e_7_center -->
+<g id="node28" class="node">
+<title>e_7_center</title>
+<polygon fill="none" stroke="black" points="1089.98,-1225.34 1082.98,-1225.34 1082.98,-1218.34 1089.98,-1218.34 1089.98,-1225.34"/>
+</g>
+<!-- coa_c&#45;&gt;e_7_center -->
+<g id="edge25" class="edge">
+<title>coa_c&#45;&gt;e_7_center</title>
+<path fill="none" stroke="black" d="M872.05,-1210.31C892.15,-1211.47 925.53,-1213.42 954.28,-1215.22 995.23,-1217.78 1005.4,-1219.65 1046.4,-1221.28 1059.75,-1221.81 1075.62,-1221.86 1082.72,-1221.85"/>
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+<!-- e_70_center -->
+<g id="node135" class="node">
+<title>e_70_center</title>
+<polygon fill="none" stroke="black" points="962.56,-1086.92 955.56,-1086.92 955.56,-1079.92 962.56,-1079.92 962.56,-1086.92"/>
+</g>
+<!-- coa_c&#45;&gt;e_70_center -->
+<g id="edge251" class="edge">
+<title>coa_c&#45;&gt;e_70_center</title>
+<path fill="none" stroke="black" d="M865.57,-1195.33C889.31,-1166.91 942.18,-1103.62 955.81,-1087.31"/>
+</g>
+<!-- e_72_center -->
+<g id="node137" class="node">
+<title>e_72_center</title>
+<polygon fill="none" stroke="black" points="618.84,-1227.66 611.84,-1227.66 611.84,-1220.66 618.84,-1220.66 618.84,-1227.66"/>
+</g>
+<!-- coa_c&#45;&gt;e_72_center -->
+<g id="edge262" class="edge">
+<title>coa_c&#45;&gt;e_72_center</title>
+<path fill="none" stroke="black" d="M835.97,-1211.33C802.79,-1215.02 729.6,-1222.62 667.67,-1225.28 649.33,-1226.07 627.35,-1224.92 618.9,-1224.4"/>
+</g>
+<!-- e_89_center -->
+<g id="node151" class="node">
+<title>e_89_center</title>
+<polygon fill="none" stroke="black" points="747.48,-1303.97 740.48,-1303.97 740.48,-1296.97 747.48,-1296.97 747.48,-1303.97"/>
+</g>
+<!-- coa_c&#45;&gt;e_89_center -->
+<g id="edge326" class="edge">
+<title>coa_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="black" d="M839.99,-1220.82C814.57,-1241.91 761.94,-1285.57 747.64,-1297.44"/>
+</g>
+<!-- nad_c -->
+<g id="node3" class="node">
+<title>nad_c</title>
+<ellipse fill="none" stroke="black" cx="1095.67" cy="-1181.36" rx="18" ry="18"/>
+<text text-anchor="middle" x="1095.67" y="-1177.66" font-family="Times,serif" font-size="14.00">nad_c</text>
+</g>
+<!-- nad_c&#45;&gt;e_0_center -->
+<g id="edge3" class="edge">
+<title>nad_c&#45;&gt;e_0_center</title>
+<path fill="none" stroke="black" d="M1097.23,-1199.45C1099.81,-1229.37 1104.8,-1287.35 1106.08,-1302.22"/>
+</g>
+<!-- nad_c&#45;&gt;e_7_center -->
+<g id="edge26" class="edge">
+<title>nad_c&#45;&gt;e_7_center</title>
+<path fill="none" stroke="black" d="M1091.61,-1199.23C1090,-1206.35 1088.29,-1213.86 1087.31,-1218.18"/>
+</g>
+<!-- e_9_center -->
+<g id="node32" class="node">
+<title>e_9_center</title>
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+</g>
+<!-- nad_c&#45;&gt;e_9_center -->
+<g id="edge36" class="edge">
+<title>nad_c&#45;&gt;e_9_center</title>
+<path fill="none" stroke="black" d="M1105.91,-1196.49C1132.36,-1235.59 1201.9,-1338.4 1215.75,-1358.88"/>
+</g>
+<!-- e_12_center -->
+<g id="node49" class="node">
+<title>e_12_center</title>
+<polygon fill="none" stroke="black" points="953.46,-947.32 946.46,-947.32 946.46,-940.32 953.46,-940.32 953.46,-947.32"/>
+</g>
+<!-- nad_c&#45;&gt;e_12_center -->
+<g id="edge66" class="edge">
+<title>nad_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M1086.01,-1165.84C1076.4,-1150.4 1061.25,-1126.01 1048.23,-1104.84 1009.45,-1041.8 962.55,-964.57 952.09,-947.34"/>
+</g>
+<!-- e_48_center -->
+<g id="node112" class="node">
+<title>e_48_center</title>
+<polygon fill="none" stroke="black" points="978.22,-955.8 971.22,-955.8 971.22,-948.8 978.22,-948.8 978.22,-955.8"/>
+</g>
+<!-- nad_c&#45;&gt;e_48_center -->
+<g id="edge151" class="edge">
+<title>nad_c&#45;&gt;e_48_center</title>
+<path fill="none" stroke="black" d="M1085.57,-1166.1C1075.63,-1150.85 1060.24,-1126.6 1048.23,-1104.84 1016.42,-1047.18 984,-973.64 976.39,-956.15"/>
+</g>
+<!-- e_60_center -->
+<g id="node127" class="node">
+<title>e_60_center</title>
+<polygon fill="none" stroke="black" points="999.26,-1261.05 992.26,-1261.05 992.26,-1254.05 999.26,-1254.05 999.26,-1261.05"/>
+</g>
+<!-- nad_c&#45;&gt;e_60_center -->
+<g id="edge210" class="edge">
+<title>nad_c&#45;&gt;e_60_center</title>
+<path fill="none" stroke="black" d="M1083.11,-1194.66C1076.58,-1201.27 1068.3,-1209.19 1060.28,-1215.58 1038.54,-1232.89 1009.53,-1249.78 999.42,-1255.5"/>
+</g>
+<!-- e_63_center -->
+<g id="node130" class="node">
+<title>e_63_center</title>
+<polygon fill="none" stroke="black" points="951.08,-1225.42 944.08,-1225.42 944.08,-1218.42 951.08,-1218.42 951.08,-1225.42"/>
+</g>
+<!-- nad_c&#45;&gt;e_63_center -->
+<g id="edge225" class="edge">
+<title>nad_c&#45;&gt;e_63_center</title>
+<path fill="none" stroke="black" d="M1077.29,-1180.04C1067.99,-1179.77 1056.56,-1180.06 1046.51,-1182.08 1007.3,-1189.98 963.83,-1212.91 951.2,-1219.88"/>
+</g>
+<!-- e_64_center -->
+<g id="node131" class="node">
+<title>e_64_center</title>
+<polygon fill="none" stroke="black" points="1000.43,-1109.55 993.43,-1109.55 993.43,-1102.55 1000.43,-1102.55 1000.43,-1109.55"/>
+</g>
+<!-- nad_c&#45;&gt;e_64_center -->
+<g id="edge230" class="edge">
+<title>nad_c&#45;&gt;e_64_center</title>
+<path fill="none" stroke="black" d="M1081.1,-1170.25C1057.93,-1152.57 1013.94,-1119.02 1000.76,-1108.97"/>
+</g>
+<!-- e_67_center -->
+<g id="node134" class="node">
+<title>e_67_center</title>
+<polygon fill="none" stroke="black" points="1281.96,-1138.68 1274.96,-1138.68 1274.96,-1131.68 1281.96,-1131.68 1281.96,-1138.68"/>
+</g>
+<!-- nad_c&#45;&gt;e_67_center -->
+<g id="edge246" class="edge">
+<title>nad_c&#45;&gt;e_67_center</title>
+<path fill="none" stroke="black" d="M1113.2,-1176.93C1154.12,-1166.59 1254.07,-1141.34 1274.7,-1136.13"/>
+</g>
+<!-- nad_c&#45;&gt;e_70_center -->
+<g id="edge253" class="edge">
+<title>nad_c&#45;&gt;e_70_center</title>
+<path fill="none" stroke="black" d="M1079.71,-1172.19C1058.52,-1159.75 1020.28,-1136.37 990.23,-1112.75 979.48,-1104.31 968.08,-1092.85 962.52,-1087.07"/>
+</g>
+<!-- accoa_c -->
+<g id="node4" class="node">
+<title>accoa_c</title>
+<ellipse fill="none" stroke="black" cx="810.37" cy="-1159.91" rx="18" ry="18"/>
+<text text-anchor="middle" x="810.37" y="-1156.21" font-family="Times,serif" font-size="14.00">accoa_c</text>
+</g>
+<!-- accoa_c&#45;&gt;e_12_center -->
+<g id="edge63" class="edge">
+<title>accoa_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M820.18,-1144.72C848.98,-1100.14 932.17,-971.36 947.51,-947.61"/>
+</g>
+<!-- e_14_center -->
+<g id="node51" class="node">
+<title>e_14_center</title>
+<polygon fill="none" stroke="black" points="664.47,-1222.08 657.47,-1222.08 657.47,-1215.08 664.47,-1215.08 664.47,-1222.08"/>
+</g>
+<!-- accoa_c&#45;&gt;e_14_center -->
+<g id="edge75" class="edge">
+<title>accoa_c&#45;&gt;e_14_center</title>
+<path fill="none" stroke="black" d="M793.52,-1166.53C759.03,-1180.07 682.13,-1210.27 664.59,-1217.16"/>
+</g>
+<!-- e_61_center -->
+<g id="node128" class="node">
+<title>e_61_center</title>
+<polygon fill="none" stroke="black" points="754.54,-1348.04 747.54,-1348.04 747.54,-1341.04 754.54,-1341.04 754.54,-1348.04"/>
+</g>
+<!-- accoa_c&#45;&gt;e_61_center -->
+<g id="edge214" class="edge">
+<title>accoa_c&#45;&gt;e_61_center</title>
+<path fill="none" stroke="black" d="M807.24,-1177.9C803.81,-1196.4 797.73,-1225.93 789.86,-1250.73 778.45,-1286.69 758.99,-1328.08 752.91,-1340.7"/>
+</g>
+<!-- e_81_center -->
+<g id="node144" class="node">
+<title>e_81_center</title>
+<polygon fill="none" stroke="black" points="595.3,-1133.39 588.3,-1133.39 588.3,-1126.39 595.3,-1126.39 595.3,-1133.39"/>
+</g>
+<!-- accoa_c&#45;&gt;e_81_center -->
+<g id="edge298" class="edge">
+<title>accoa_c&#45;&gt;e_81_center</title>
+<path fill="none" stroke="black" d="M792.1,-1158.48C775.18,-1157.08 749.32,-1154.72 726.96,-1151.83 674.62,-1145.05 611.41,-1133.53 595.55,-1130.59"/>
+</g>
+<!-- nadh_c -->
+<g id="node5" class="node">
+<title>nadh_c</title>
+<ellipse fill="none" stroke="black" cx="1046.46" cy="-1201.68" rx="18" ry="18"/>
+<text text-anchor="middle" x="1046.46" y="-1197.98" font-family="Times,serif" font-size="14.00">nadh_c</text>
+</g>
+<!-- e_66_center -->
+<g id="node133" class="node">
+<title>e_66_center</title>
+<polygon fill="none" stroke="black" points="969.17,-1479.02 962.17,-1479.02 962.17,-1472.02 969.17,-1472.02 969.17,-1479.02"/>
+</g>
+<!-- nadh_c&#45;&gt;e_66_center -->
+<g id="edge240" class="edge">
+<title>nadh_c&#45;&gt;e_66_center</title>
+<path fill="none" stroke="black" d="M1041.28,-1219.22C1024.91,-1274.71 974.88,-1444.3 966.78,-1471.75"/>
+</g>
+<!-- e_91_center -->
+<g id="node154" class="node">
+<title>e_91_center</title>
+<polygon fill="none" stroke="black" points="1119.77,-1275.95 1112.77,-1275.95 1112.77,-1268.95 1119.77,-1268.95 1119.77,-1275.95"/>
+</g>
+<!-- nadh_c&#45;&gt;e_91_center -->
+<g id="edge336" class="edge">
+<title>nadh_c&#45;&gt;e_91_center</title>
+<path fill="none" stroke="black" d="M1059.26,-1214.66C1075.64,-1231.26 1103.04,-1259.03 1112.73,-1268.87"/>
+</g>
+<!-- h_c -->
+<g id="node6" class="node">
+<title>h_c</title>
+<ellipse fill="none" stroke="black" cx="911.41" cy="-1310.11" rx="18" ry="18"/>
+<text text-anchor="middle" x="911.41" y="-1306.41" font-family="Times,serif" font-size="14.00">h_c</text>
+</g>
+<!-- e_15_center -->
+<g id="node55" class="node">
+<title>e_15_center</title>
+<polygon fill="none" stroke="black" points="740.69,-1560.2 733.69,-1560.2 733.69,-1553.2 740.69,-1553.2 740.69,-1560.2"/>
+</g>
+<!-- h_c&#45;&gt;e_15_center -->
+<g id="edge83" class="edge">
+<title>h_c&#45;&gt;e_15_center</title>
+<path fill="none" stroke="black" d="M899.89,-1324.51C878.68,-1351.19 832.36,-1410.34 796.42,-1462.44 772.72,-1496.8 746.85,-1540.28 739.34,-1553.03"/>
+</g>
+<!-- e_54_center -->
+<g id="node119" class="node">
+<title>e_54_center</title>
+<polygon fill="none" stroke="black" points="1093.53,-1117 1086.53,-1117 1086.53,-1110 1093.53,-1110 1093.53,-1117"/>
+</g>
+<!-- h_c&#45;&gt;e_54_center -->
+<g id="edge185" class="edge">
+<title>h_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" d="M923.69,-1296.6C960.1,-1256.52 1066.24,-1139.68 1086.62,-1117.25"/>
+</g>
+<!-- h_c&#45;&gt;e_66_center -->
+<g id="edge241" class="edge">
+<title>h_c&#45;&gt;e_66_center</title>
+<path fill="none" stroke="black" d="M913.63,-1328.02C915.97,-1344.85 920.22,-1370.64 926.62,-1392.38 928.5,-1398.77 929.61,-1400.16 932.32,-1406.25 943.63,-1431.61 958.58,-1461.49 963.78,-1471.8"/>
+</g>
+<!-- e_82_center -->
+<g id="node145" class="node">
+<title>e_82_center</title>
+<polygon fill="none" stroke="black" points="780.91,-1045.84 773.91,-1045.84 773.91,-1038.84 780.91,-1038.84 780.91,-1045.84"/>
+</g>
+<!-- h_c&#45;&gt;e_82_center -->
+<g id="edge303" class="edge">
+<title>h_c&#45;&gt;e_82_center</title>
+<path fill="none" stroke="black" d="M905.12,-1292.95C897.72,-1272.85 884.98,-1238.6 873.52,-1209.37 871.08,-1203.17 870.81,-1201.46 867.85,-1195.49 837.11,-1133.53 790.92,-1062.75 779.86,-1046.02"/>
+</g>
+<!-- e_0_center&#45;&gt;accoa_c -->
+<g id="edge4" class="edge">
+<title>e_0_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="black" d="M1102.89,-1303.69C1089.9,-1296.01 1043.15,-1268.84 1002.46,-1250.85 975.85,-1239.08 967.5,-1240.37 940.88,-1228.62 902.9,-1211.87 860.69,-1188.78 834.84,-1174.1"/>
+<polygon fill="black" stroke="black" points="836.51,-1171.03 826.09,-1169.1 833.03,-1177.1 836.51,-1171.03"/>
+</g>
+<!-- e_0_center&#45;&gt;nadh_c -->
+<g id="edge5" class="edge">
+<title>e_0_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" d="M1104.11,-1301.81C1097.06,-1289.58 1075.21,-1251.61 1060.52,-1226.1"/>
+<polygon fill="black" stroke="black" points="1063.5,-1224.26 1055.48,-1217.34 1057.43,-1227.75 1063.5,-1224.26"/>
+</g>
+<!-- e_0_center&#45;&gt;h_c -->
+<g id="edge6" class="edge">
+<title>e_0_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1102.67,-1305.85C1082.74,-1306.29 987.81,-1308.41 939.62,-1309.49"/>
+<polygon fill="black" stroke="black" points="939.46,-1305.99 929.54,-1309.71 939.62,-1312.99 939.46,-1305.99"/>
+</g>
+<!-- acald_e -->
+<g id="node8" class="node">
+<title>acald_e</title>
+<ellipse fill="none" stroke="black" cx="1845.44" cy="-1428.03" rx="18" ry="18"/>
+<text text-anchor="middle" x="1845.44" y="-1424.33" font-family="Times,serif" font-size="14.00">acald_e</text>
+</g>
+<!-- acald_e&#45;&gt;acald_c -->
+<g id="edge7" class="edge">
+<title>acald_e&#45;&gt;acald_c</title>
+<path fill="none" stroke="black" d="M1827.54,-1425.55C1766.43,-1417.06 1565.72,-1389.18 1491.58,-1378.88"/>
+<polygon fill="black" stroke="black" points="1491.98,-1375.41 1481.59,-1377.5 1491.01,-1382.34 1491.98,-1375.41"/>
+</g>
+<!-- e_20_target -->
+<g id="node64" class="node">
+<title>e_20_target</title>
+<ellipse fill="black" stroke="black" cx="2089.18" cy="-1466.88" rx="1.8" ry="1.8"/>
+</g>
+<!-- acald_e&#45;&gt;e_20_target -->
+<g id="edge99" class="edge">
+<title>acald_e&#45;&gt;e_20_target</title>
+<path fill="none" stroke="black" d="M1863.36,-1430.89C1910.67,-1438.43 2037.97,-1458.72 2077.38,-1465"/>
+<polygon fill="black" stroke="black" points="2076.84,-1468.45 2087.26,-1466.57 2077.94,-1461.54 2076.84,-1468.45"/>
+</g>
+<!-- atp_c -->
+<g id="node9" class="node">
+<title>atp_c</title>
+<ellipse fill="none" stroke="black" cx="722.32" cy="-1049.99" rx="18" ry="18"/>
+<text text-anchor="middle" x="722.32" y="-1046.29" font-family="Times,serif" font-size="14.00">atp_c</text>
+</g>
+<!-- e_2_center -->
+<g id="node13" class="node">
+<title>e_2_center</title>
+<polygon fill="none" stroke="black" points="489.88,-1132.95 482.88,-1132.95 482.88,-1125.95 489.88,-1125.95 489.88,-1132.95"/>
+</g>
+<!-- atp_c&#45;&gt;e_2_center -->
+<g id="edge8" class="edge">
+<title>atp_c&#45;&gt;e_2_center</title>
+<path fill="none" stroke="black" d="M704.97,-1055.83C655.37,-1072.53 514.98,-1119.81 490.15,-1128.18"/>
+</g>
+<!-- e_6_center -->
+<g id="node24" class="node">
+<title>e_6_center</title>
+<polygon fill="none" stroke="black" points="528.76,-914.56 521.76,-914.56 521.76,-907.56 528.76,-907.56 528.76,-914.56"/>
+</g>
+<!-- atp_c&#45;&gt;e_6_center -->
+<g id="edge22" class="edge">
+<title>atp_c&#45;&gt;e_6_center</title>
+<path fill="none" stroke="black" d="M707.5,-1039.54C666.15,-1010.39 551.04,-929.23 528.96,-913.66"/>
+</g>
+<!-- e_10_center -->
+<g id="node34" class="node">
+<title>e_10_center</title>
+<polygon fill="none" stroke="black" points="711.89,-1184.23 704.89,-1184.23 704.89,-1177.23 711.89,-1177.23 711.89,-1184.23"/>
+</g>
+<!-- atp_c&#45;&gt;e_10_center -->
+<g id="edge40" class="edge">
+<title>atp_c&#45;&gt;e_10_center</title>
+<path fill="none" stroke="black" d="M718.08,-1067.5C714.32,-1084.05 709.17,-1109.65 707.37,-1132.21 706.04,-1149.01 707.41,-1169.18 708.08,-1177.2"/>
+</g>
+<!-- atp_c&#45;&gt;e_12_center -->
+<g id="edge62" class="edge">
+<title>atp_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M739.54,-1044.64C770.58,-1034.68 837.55,-1011.79 890.07,-983.87 912.6,-971.89 937.25,-953.57 946.34,-946.62"/>
+</g>
+<!-- e_50_center -->
+<g id="node115" class="node">
+<title>e_50_center</title>
+<polygon fill="none" stroke="black" points="962.14,-1043.72 955.14,-1043.72 955.14,-1036.72 962.14,-1036.72 962.14,-1043.72"/>
+</g>
+<!-- atp_c&#45;&gt;e_50_center -->
+<g id="edge160" class="edge">
+<title>atp_c&#45;&gt;e_50_center</title>
+<path fill="none" stroke="black" d="M740.46,-1050.25C752.78,-1050.3 769.45,-1050.1 784.11,-1049.04 804.61,-1047.56 809.48,-1044.65 829.97,-1043.1 879.43,-1039.35 939.87,-1039.94 955.05,-1040.16"/>
+</g>
+<!-- e_51_center -->
+<g id="node116" class="node">
+<title>e_51_center</title>
+<polygon fill="none" stroke="black" points="627.63,-1045.2 620.63,-1045.2 620.63,-1038.2 627.63,-1038.2 627.63,-1045.2"/>
+</g>
+<!-- atp_c&#45;&gt;e_51_center -->
+<g id="edge167" class="edge">
+<title>atp_c&#45;&gt;e_51_center</title>
+<path fill="none" stroke="black" d="M704.31,-1048.47C680.39,-1046.45 639.75,-1043.02 627.64,-1042"/>
+</g>
+<!-- e_71_center -->
+<g id="node136" class="node">
+<title>e_71_center</title>
+<polygon fill="none" stroke="black" points="842.37,-904.95 835.37,-904.95 835.37,-897.95 842.37,-897.95 842.37,-904.95"/>
+</g>
+<!-- atp_c&#45;&gt;e_71_center -->
+<g id="edge257" class="edge">
+<title>atp_c&#45;&gt;e_71_center</title>
+<path fill="none" stroke="black" d="M731.83,-1034.33C742.73,-1016.77 761.49,-987.7 780.02,-964.44 799.22,-940.32 825.63,-914.23 835.21,-904.96"/>
+</g>
+<!-- e_74_center -->
+<g id="node138" class="node">
+<title>e_74_center</title>
+<polygon fill="none" stroke="black" points="668.33,-810.83 661.33,-810.83 661.33,-803.83 668.33,-803.83 668.33,-810.83"/>
+</g>
+<!-- atp_c&#45;&gt;e_74_center -->
+<g id="edge268" class="edge">
+<title>atp_c&#45;&gt;e_74_center</title>
+<path fill="none" stroke="black" d="M711.7,-1035.26C706.39,-1027.04 700.48,-1016.37 697.5,-1005.89 675.67,-928.93 666.75,-830.77 665.11,-810.93"/>
+</g>
+<!-- e_79_center -->
+<g id="node142" class="node">
+<title>e_79_center</title>
+<polygon fill="none" stroke="black" points="875.97,-895.95 868.97,-895.95 868.97,-888.95 875.97,-888.95 875.97,-895.95"/>
+</g>
+<!-- atp_c&#45;&gt;e_79_center -->
+<g id="edge286" class="edge">
+<title>atp_c&#45;&gt;e_79_center</title>
+<path fill="none" stroke="black" d="M730.98,-1034.08C741.26,-1016.05 759.6,-986.3 780.02,-964.44 810.29,-932.03 856.05,-902.61 868.96,-894.6"/>
+</g>
+<!-- e_80_center -->
+<g id="node143" class="node">
+<title>e_80_center</title>
+<polygon fill="none" stroke="black" points="668.01,-1026.38 661.01,-1026.38 661.01,-1019.38 668.01,-1019.38 668.01,-1026.38"/>
+</g>
+<!-- atp_c&#45;&gt;e_80_center -->
+<g id="edge291" class="edge">
+<title>atp_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="black" d="M705.91,-1042.29C692.82,-1036.16 675.51,-1028.04 668.11,-1024.57"/>
+</g>
+<!-- atp_c&#45;&gt;e_89_center -->
+<g id="edge325" class="edge">
+<title>atp_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="black" d="M728.97,-1066.98C735,-1083.39 743.41,-1109.08 746.57,-1132.24 755.5,-1197.65 746.65,-1278.68 744.45,-1296.77"/>
+</g>
+<!-- ac_c -->
+<g id="node10" class="node">
+<title>ac_c</title>
+<ellipse fill="none" stroke="black" cx="421.51" cy="-1397.64" rx="18" ry="18"/>
+<text text-anchor="middle" x="421.51" y="-1393.94" font-family="Times,serif" font-size="14.00">ac_c</text>
+</g>
+<!-- ac_c&#45;&gt;e_2_center -->
+<g id="edge9" class="edge">
+<title>ac_c&#45;&gt;e_2_center</title>
+<path fill="none" stroke="black" d="M425.77,-1380.05C439.02,-1325.27 479.02,-1159.89 485.49,-1133.12"/>
+</g>
+<!-- actp_c -->
+<g id="node11" class="node">
+<title>actp_c</title>
+<ellipse fill="none" stroke="black" cx="325.97" cy="-1083.54" rx="18" ry="18"/>
+<text text-anchor="middle" x="325.97" y="-1079.84" font-family="Times,serif" font-size="14.00">actp_c</text>
+</g>
+<!-- adp_c -->
+<g id="node12" class="node">
+<title>adp_c</title>
+<ellipse fill="none" stroke="black" cx="717.1" cy="-1005.95" rx="18" ry="18"/>
+<text text-anchor="middle" x="717.1" y="-1002.25" font-family="Times,serif" font-size="14.00">adp_c</text>
+</g>
+<!-- e_11_center -->
+<g id="node35" class="node">
+<title>e_11_center</title>
+<polygon fill="none" stroke="black" points="786.66,-1247.53 779.66,-1247.53 779.66,-1240.53 786.66,-1240.53 786.66,-1247.53"/>
+</g>
+<!-- adp_c&#45;&gt;e_11_center -->
+<g id="edge47" class="edge">
+<title>adp_c&#45;&gt;e_11_center</title>
+<path fill="none" stroke="black" d="M727.54,-1020.75C732.79,-1029 738.71,-1039.69 741.92,-1050.11 747.83,-1069.36 777.39,-1215.44 782.43,-1240.41"/>
+</g>
+<!-- adp_c&#45;&gt;e_82_center -->
+<g id="edge304" class="edge">
+<title>adp_c&#45;&gt;e_82_center</title>
+<path fill="none" stroke="black" d="M732.63,-1015.32C746.32,-1023.58 765.3,-1035.03 773.44,-1039.95"/>
+</g>
+<!-- e_2_center&#45;&gt;actp_c -->
+<g id="edge10" class="edge">
+<title>e_2_center&#45;&gt;actp_c</title>
+<path fill="none" stroke="black" d="M482.73,-1128.4C465.69,-1123.53 393.2,-1102.78 353.04,-1091.29"/>
+<polygon fill="black" stroke="black" points="353.92,-1087.9 343.34,-1088.52 351.99,-1094.63 353.92,-1087.9"/>
+</g>
+<!-- e_2_center&#45;&gt;adp_c -->
+<g id="edge11" class="edge">
+<title>e_2_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" d="M490,-1127.51C512.88,-1115.26 638.04,-1048.27 692.16,-1019.3"/>
+<polygon fill="black" stroke="black" points="693.94,-1022.32 701.1,-1014.51 690.63,-1016.15 693.94,-1022.32"/>
+</g>
+<!-- cit_c -->
+<g id="node14" class="node">
+<title>cit_c</title>
+<ellipse fill="none" stroke="black" cx="368.41" cy="-1238.7" rx="18" ry="18"/>
+<text text-anchor="middle" x="368.41" y="-1235" font-family="Times,serif" font-size="14.00">cit_c</text>
+</g>
+<!-- e_3_center -->
+<g id="node17" class="node">
+<title>e_3_center</title>
+<polygon fill="none" stroke="black" points="393.82,-1145.99 386.82,-1145.99 386.82,-1138.99 393.82,-1138.99 393.82,-1145.99"/>
+</g>
+<!-- cit_c&#45;&gt;e_3_center -->
+<g id="edge12" class="edge">
+<title>cit_c&#45;&gt;e_3_center</title>
+<path fill="none" stroke="black" d="M372.43,-1221.05C377.72,-1197.83 386.67,-1158.53 389.46,-1146.26"/>
+</g>
+<!-- acon_C_c -->
+<g id="node15" class="node">
+<title>acon_C_c</title>
+<ellipse fill="none" stroke="black" cx="208.35" cy="-1202.14" rx="18" ry="18"/>
+<text text-anchor="middle" x="208.35" y="-1198.44" font-family="Times,serif" font-size="14.00">acon_C_c</text>
+</g>
+<!-- e_4_center -->
+<g id="node19" class="node">
+<title>e_4_center</title>
+<polygon fill="none" stroke="black" points="453.87,-1244.9 446.87,-1244.9 446.87,-1237.9 453.87,-1237.9 453.87,-1244.9"/>
+</g>
+<!-- acon_C_c&#45;&gt;e_4_center -->
+<g id="edge15" class="edge">
+<title>acon_C_c&#45;&gt;e_4_center</title>
+<path fill="none" stroke="black" d="M226.74,-1203.12C256.67,-1204.94 317.69,-1209.54 368.53,-1219.1 399.21,-1224.87 435.2,-1236.38 446.67,-1240.16"/>
+</g>
+<!-- h2o_c -->
+<g id="node16" class="node">
+<title>h2o_c</title>
+<ellipse fill="none" stroke="black" cx="726.97" cy="-1132.23" rx="18" ry="18"/>
+<text text-anchor="middle" x="726.97" y="-1128.53" font-family="Times,serif" font-size="14.00">h2o_c</text>
+</g>
+<!-- h2o_c&#45;&gt;e_4_center -->
+<g id="edge16" class="edge">
+<title>h2o_c&#45;&gt;e_4_center</title>
+<path fill="none" stroke="black" d="M710.08,-1138.89C654.96,-1160.65 482.19,-1228.84 454.21,-1239.89"/>
+</g>
+<!-- h2o_c&#45;&gt;e_10_center -->
+<g id="edge41" class="edge">
+<title>h2o_c&#45;&gt;e_10_center</title>
+<path fill="none" stroke="black" d="M720.47,-1149.19C716.62,-1159.25 712.07,-1171.14 709.81,-1177.04"/>
+</g>
+<!-- h2o_c&#45;&gt;e_12_center -->
+<g id="edge58" class="edge">
+<title>h2o_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M737.77,-1117.34C744.05,-1109.12 752.35,-1098.95 760.71,-1090.78 828.84,-1024.2 926.52,-959.14 946.36,-946.16"/>
+</g>
+<!-- h2o_c&#45;&gt;e_14_center -->
+<g id="edge76" class="edge">
+<title>h2o_c&#45;&gt;e_14_center</title>
+<path fill="none" stroke="black" d="M715.78,-1146.87C700.18,-1167.28 672.83,-1203.06 663.89,-1214.76"/>
+</g>
+<!-- e_40_center -->
+<g id="node99" class="node">
+<title>e_40_center</title>
+<polygon fill="none" stroke="black" points="793.71,-837.53 786.71,-837.53 786.71,-830.53 793.71,-830.53 793.71,-837.53"/>
+</g>
+<!-- h2o_c&#45;&gt;e_40_center -->
+<g id="edge121" class="edge">
+<title>h2o_c&#45;&gt;e_40_center</title>
+<path fill="none" stroke="black" d="M730.74,-1114.46C743.29,-1055.28 783.24,-866.89 789.41,-837.81"/>
+</g>
+<!-- e_45_center -->
+<g id="node107" class="node">
+<title>e_45_center</title>
+<polygon fill="none" stroke="black" points="806.62,-1472.64 799.62,-1472.64 799.62,-1465.64 806.62,-1465.64 806.62,-1472.64"/>
+</g>
+<!-- h2o_c&#45;&gt;e_45_center -->
+<g id="edge138" class="edge">
+<title>h2o_c&#45;&gt;e_45_center</title>
+<path fill="none" stroke="black" d="M730.96,-1149.86C745.53,-1214.31 795.38,-1434.88 802.32,-1465.58"/>
+</g>
+<!-- h2o_c&#45;&gt;e_51_center -->
+<g id="edge169" class="edge">
+<title>h2o_c&#45;&gt;e_51_center</title>
+<path fill="none" stroke="black" d="M713.1,-1120.02C689.2,-1098.98 641.48,-1056.98 627.85,-1044.98"/>
+</g>
+<!-- e_52_center -->
+<g id="node117" class="node">
+<title>e_52_center</title>
+<polygon fill="none" stroke="black" points="1058.43,-1101.64 1051.43,-1101.64 1051.43,-1094.64 1058.43,-1094.64 1058.43,-1101.64"/>
+</g>
+<!-- h2o_c&#45;&gt;e_52_center -->
+<g id="edge175" class="edge">
+<title>h2o_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="black" d="M744.78,-1129.34C787.17,-1122.63 897.43,-1106 990.23,-1099.35 1013.54,-1097.68 1041.68,-1097.92 1051.42,-1098.07"/>
+</g>
+<!-- e_53_center -->
+<g id="node118" class="node">
+<title>e_53_center</title>
+<polygon fill="none" stroke="black" points="1025.69,-977.67 1018.69,-977.67 1018.69,-970.67 1025.69,-970.67 1025.69,-977.67"/>
+</g>
+<!-- h2o_c&#45;&gt;e_53_center -->
+<g id="edge181" class="edge">
+<title>h2o_c&#45;&gt;e_53_center</title>
+<path fill="none" stroke="black" d="M745.25,-1130.14C754.18,-1128.88 765.03,-1126.97 774.53,-1124.26 780.94,-1122.42 782.46,-1121.57 788.39,-1118.53 886.1,-1068.62 996.96,-991.87 1018.47,-976.79"/>
+</g>
+<!-- h2o_c&#45;&gt;e_61_center -->
+<g id="edge215" class="edge">
+<title>h2o_c&#45;&gt;e_61_center</title>
+<path fill="none" stroke="black" d="M730.42,-1150.06C735.97,-1179.74 746.66,-1241.2 750.68,-1293.77 752.03,-1311.35 751.49,-1332.45 751.19,-1340.84"/>
+</g>
+<!-- e_75_center -->
+<g id="node139" class="node">
+<title>e_75_center</title>
+<polygon fill="none" stroke="black" points="1082.37,-1040.83 1075.37,-1040.83 1075.37,-1033.83 1082.37,-1033.83 1082.37,-1040.83"/>
+</g>
+<!-- h2o_c&#45;&gt;e_75_center -->
+<g id="edge272" class="edge">
+<title>h2o_c&#45;&gt;e_75_center</title>
+<path fill="none" stroke="black" d="M745.13,-1129.67C754.03,-1128.3 764.89,-1126.43 774.53,-1124.26 838.04,-1109.91 1044.8,-1047.62 1075.14,-1038.45"/>
+</g>
+<!-- e_78_center -->
+<g id="node141" class="node">
+<title>e_78_center</title>
+<polygon fill="none" stroke="black" points="885.39,-1033.68 878.39,-1033.68 878.39,-1026.68 885.39,-1026.68 885.39,-1033.68"/>
+</g>
+<!-- h2o_c&#45;&gt;e_78_center -->
+<g id="edge282" class="edge">
+<title>h2o_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="black" d="M737.73,-1117.3C744,-1109.07 752.31,-1098.91 760.71,-1090.78 782.92,-1069.31 789.23,-1064.03 816.08,-1048.74 837.74,-1036.41 868.15,-1031.82 878.38,-1030.57"/>
+</g>
+<!-- h2o_c&#45;&gt;e_80_center -->
+<g id="edge293" class="edge">
+<title>h2o_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="black" d="M718.02,-1116.56C703.32,-1090.81 674.85,-1040.99 666.73,-1026.76"/>
+</g>
+<!-- e_3_center&#45;&gt;acon_C_c -->
+<g id="edge13" class="edge">
+<title>e_3_center&#45;&gt;acon_C_c</title>
+<path fill="none" stroke="black" d="M386.52,-1143.73C367.34,-1150.02 280.36,-1178.53 235.42,-1193.26"/>
+<polygon fill="black" stroke="black" points="234.14,-1190 225.73,-1196.44 236.32,-1196.65 234.14,-1190"/>
+</g>
+<!-- e_3_center&#45;&gt;h2o_c -->
+<g id="edge14" class="edge">
+<title>e_3_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="black" d="M394.02,-1142.39C414.46,-1141.86 515.74,-1139.17 598.5,-1136.59 632.85,-1135.52 672.36,-1134.16 698.4,-1133.24"/>
+<polygon fill="black" stroke="black" points="698.81,-1136.73 708.68,-1132.88 698.56,-1129.74 698.81,-1136.73"/>
+</g>
+<!-- icit_c -->
+<g id="node18" class="node">
+<title>icit_c</title>
+<ellipse fill="none" stroke="black" cx="668.2" cy="-1365.43" rx="18" ry="18"/>
+<text text-anchor="middle" x="668.2" y="-1361.73" font-family="Times,serif" font-size="14.00">icit_c</text>
+</g>
+<!-- e_58_center -->
+<g id="node124" class="node">
+<title>e_58_center</title>
+<polygon fill="none" stroke="black" points="1001.97,-1169.74 994.97,-1169.74 994.97,-1162.74 1001.97,-1162.74 1001.97,-1169.74"/>
+</g>
+<!-- icit_c&#45;&gt;e_58_center -->
+<g id="edge202" class="edge">
+<title>icit_c&#45;&gt;e_58_center</title>
+<path fill="none" stroke="black" d="M683.69,-1356.09C744.39,-1319.48 964.29,-1186.85 994.92,-1168.38"/>
+</g>
+<!-- e_59_center -->
+<g id="node126" class="node">
+<title>e_59_center</title>
+<polygon fill="none" stroke="black" points="543.05,-1617.62 536.05,-1617.62 536.05,-1610.62 543.05,-1610.62 543.05,-1617.62"/>
+</g>
+<!-- icit_c&#45;&gt;e_59_center -->
+<g id="edge206" class="edge">
+<title>icit_c&#45;&gt;e_59_center</title>
+<path fill="none" stroke="black" d="M659.76,-1381.75C633.6,-1432.32 554.83,-1584.59 541.48,-1610.38"/>
+</g>
+<!-- e_4_center&#45;&gt;icit_c -->
+<g id="edge17" class="edge">
+<title>e_4_center&#45;&gt;icit_c</title>
+<path fill="none" stroke="black" d="M454.15,-1243.56C476.49,-1256.27 591.98,-1322.03 643.43,-1351.33"/>
+<polygon fill="black" stroke="black" points="641.83,-1354.44 652.25,-1356.35 645.29,-1348.36 641.83,-1354.44"/>
+</g>
+<!-- ac_e -->
+<g id="node20" class="node">
+<title>ac_e</title>
+<ellipse fill="none" stroke="black" cx="406.26" cy="-1866.13" rx="18" ry="18"/>
+<text text-anchor="middle" x="406.26" y="-1862.43" font-family="Times,serif" font-size="14.00">ac_e</text>
+</g>
+<!-- e_5_center -->
+<g id="node22" class="node">
+<title>e_5_center</title>
+<polygon fill="none" stroke="black" points="641.65,-1579.97 634.65,-1579.97 634.65,-1572.97 641.65,-1572.97 641.65,-1579.97"/>
+</g>
+<!-- ac_e&#45;&gt;e_5_center -->
+<g id="edge18" class="edge">
+<title>ac_e&#45;&gt;e_5_center</title>
+<path fill="none" stroke="black" d="M417.76,-1851.77C460.9,-1797.89 611.8,-1609.39 635.11,-1580.26"/>
+</g>
+<!-- e_19_target -->
+<g id="node63" class="node">
+<title>e_19_target</title>
+<ellipse fill="black" stroke="black" cx="236.03" cy="-2074.13" rx="1.8" ry="1.8"/>
+</g>
+<!-- ac_e&#45;&gt;e_19_target -->
+<g id="edge98" class="edge">
+<title>ac_e&#45;&gt;e_19_target</title>
+<path fill="none" stroke="black" d="M394.83,-1880.1C362.54,-1919.55 271.24,-2031.11 243.88,-2064.55"/>
+<polygon fill="black" stroke="black" points="241.02,-2062.51 237.4,-2072.47 246.44,-2066.95 241.02,-2062.51"/>
+</g>
+<!-- h_e -->
+<g id="node21" class="node">
+<title>h_e</title>
+<ellipse fill="none" stroke="black" cx="917.98" cy="-1515.32" rx="18" ry="18"/>
+<text text-anchor="middle" x="917.98" y="-1511.62" font-family="Times,serif" font-size="14.00">h_e</text>
+</g>
+<!-- h_e&#45;&gt;e_5_center -->
+<g id="edge19" class="edge">
+<title>h_e&#45;&gt;e_5_center</title>
+<path fill="none" stroke="black" d="M900.03,-1518.05C866.5,-1523.28 792.2,-1535.48 730.49,-1550 695.75,-1558.17 654.56,-1571.18 641.98,-1575.23"/>
+</g>
+<!-- e_8_center -->
+<g id="node30" class="node">
+<title>e_8_center</title>
+<polygon fill="none" stroke="black" points="1208.84,-1472.44 1201.84,-1472.44 1201.84,-1465.44 1208.84,-1465.44 1208.84,-1472.44"/>
+</g>
+<!-- h_e&#45;&gt;e_8_center -->
+<g id="edge32" class="edge">
+<title>h_e&#45;&gt;e_8_center</title>
+<path fill="none" stroke="black" d="M935.45,-1510.95C974.15,-1501.5 1070.18,-1479.27 1152.03,-1470.37 1170.62,-1468.35 1193.06,-1468.63 1201.7,-1468.84"/>
+</g>
+<!-- h_e&#45;&gt;e_11_center -->
+<g id="edge46" class="edge">
+<title>h_e&#45;&gt;e_11_center</title>
+<path fill="none" stroke="black" d="M909.95,-1499.17C883.31,-1445.55 798.73,-1275.38 785.04,-1247.82"/>
+</g>
+<!-- e_16_center -->
+<g id="node58" class="node">
+<title>e_16_center</title>
+<polygon fill="none" stroke="black" points="1128.72,-1639.08 1121.72,-1639.08 1121.72,-1632.08 1128.72,-1632.08 1128.72,-1639.08"/>
+</g>
+<!-- h_e&#45;&gt;e_16_center -->
+<g id="edge88" class="edge">
+<title>h_e&#45;&gt;e_16_center</title>
+<path fill="none" stroke="black" d="M933.56,-1524.36C977.24,-1549.71 1099.16,-1620.46 1121.63,-1633.5"/>
+</g>
+<!-- e_18_center -->
+<g id="node62" class="node">
+<title>e_18_center</title>
+<polygon fill="none" stroke="black" points="1079.89,-1678.71 1072.89,-1678.71 1072.89,-1671.71 1079.89,-1671.71 1079.89,-1678.71"/>
+</g>
+<!-- h_e&#45;&gt;e_18_center -->
+<g id="edge94" class="edge">
+<title>h_e&#45;&gt;e_18_center</title>
+<path fill="none" stroke="black" d="M930.68,-1528.14C964.16,-1561.93 1053.58,-1652.19 1072.74,-1671.53"/>
+</g>
+<!-- e_30_target -->
+<g id="node80" class="node">
+<title>e_30_target</title>
+<ellipse fill="black" stroke="black" cx="998.28" cy="-1791.02" rx="1.8" ry="1.8"/>
+</g>
+<!-- h_e&#45;&gt;e_30_target -->
+<g id="edge109" class="edge">
+<title>h_e&#45;&gt;e_30_target</title>
+<path fill="none" stroke="black" d="M923.13,-1532.99C938.22,-1584.8 982.1,-1735.44 994.8,-1779.06"/>
+<polygon fill="black" stroke="black" points="991.48,-1780.17 997.64,-1788.79 998.2,-1778.21 991.48,-1780.17"/>
+</g>
+<!-- e_41_center -->
+<g id="node101" class="node">
+<title>e_41_center</title>
+<polygon fill="none" stroke="black" points="623.85,-1525.03 616.85,-1525.03 616.85,-1518.03 623.85,-1518.03 623.85,-1525.03"/>
+</g>
+<!-- h_e&#45;&gt;e_41_center -->
+<g id="edge126" class="edge">
+<title>h_e&#45;&gt;e_41_center</title>
+<path fill="none" stroke="black" d="M899.81,-1515.7C840.24,-1516.95 653,-1520.85 624.11,-1521.45"/>
+</g>
+<!-- e_46_center -->
+<g id="node108" class="node">
+<title>e_46_center</title>
+<polygon fill="none" stroke="black" points="1009.41,-1702.36 1002.41,-1702.36 1002.41,-1695.36 1009.41,-1695.36 1009.41,-1702.36"/>
+</g>
+<!-- h_e&#45;&gt;e_46_center -->
+<g id="edge141" class="edge">
+<title>h_e&#45;&gt;e_46_center</title>
+<path fill="none" stroke="black" d="M925.79,-1531.61C945.12,-1571.97 994.39,-1674.81 1004.2,-1695.29"/>
+</g>
+<!-- e_55_center -->
+<g id="node120" class="node">
+<title>e_55_center</title>
+<polygon fill="none" stroke="black" points="1216.28,-1409.79 1209.28,-1409.79 1209.28,-1402.79 1216.28,-1402.79 1216.28,-1409.79"/>
+</g>
+<!-- h_e&#45;&gt;e_55_center -->
+<g id="edge191" class="edge">
+<title>h_e&#45;&gt;e_55_center</title>
+<path fill="none" stroke="black" d="M935.11,-1508.99C993.11,-1487.54 1180.15,-1418.36 1209.02,-1407.68"/>
+</g>
+<!-- e_62_center -->
+<g id="node129" class="node">
+<title>e_62_center</title>
+<polygon fill="none" stroke="black" points="1122.92,-1561.31 1115.92,-1561.31 1115.92,-1554.31 1122.92,-1554.31 1122.92,-1561.31"/>
+</g>
+<!-- h_e&#45;&gt;e_62_center -->
+<g id="edge220" class="edge">
+<title>h_e&#45;&gt;e_62_center</title>
+<path fill="none" stroke="black" d="M935.86,-1519.09C980.34,-1528.48 1094.01,-1552.45 1115.78,-1557.04"/>
+</g>
+<!-- e_77_center -->
+<g id="node140" class="node">
+<title>e_77_center</title>
+<polygon fill="none" stroke="black" points="684.54,-1447.11 677.54,-1447.11 677.54,-1440.11 684.54,-1440.11 684.54,-1447.11"/>
+</g>
+<!-- h_e&#45;&gt;e_77_center -->
+<g id="edge276" class="edge">
+<title>h_e&#45;&gt;e_77_center</title>
+<path fill="none" stroke="black" d="M900.56,-1510.05C850.76,-1494.98 709.76,-1452.31 684.83,-1444.76"/>
+</g>
+<!-- e_83_center -->
+<g id="node146" class="node">
+<title>e_83_center</title>
+<polygon fill="none" stroke="black" points="647.66,-1323.57 640.66,-1323.57 640.66,-1316.57 647.66,-1316.57 647.66,-1323.57"/>
+</g>
+<!-- h_e&#45;&gt;e_83_center -->
+<g id="edge308" class="edge">
+<title>h_e&#45;&gt;e_83_center</title>
+<path fill="none" stroke="black" d="M903.26,-1504.83C850.83,-1467.44 674.87,-1341.97 647.69,-1322.59"/>
+</g>
+<!-- e_86_center -->
+<g id="node148" class="node">
+<title>e_86_center</title>
+<polygon fill="none" stroke="black" points="869.69,-1649.3 862.69,-1649.3 862.69,-1642.3 869.69,-1642.3 869.69,-1649.3"/>
+</g>
+<!-- h_e&#45;&gt;e_86_center -->
+<g id="edge314" class="edge">
+<title>h_e&#45;&gt;e_86_center</title>
+<path fill="none" stroke="black" d="M911.32,-1532.11C899.19,-1562.67 874.16,-1625.73 867.73,-1641.94"/>
+</g>
+<!-- e_87_center -->
+<g id="node149" class="node">
+<title>e_87_center</title>
+<polygon fill="none" stroke="black" points="900.54,-1654.28 893.54,-1654.28 893.54,-1647.28 900.54,-1647.28 900.54,-1654.28"/>
+</g>
+<!-- h_e&#45;&gt;e_87_center -->
+<g id="edge317" class="edge">
+<title>h_e&#45;&gt;e_87_center</title>
+<path fill="none" stroke="black" d="M915.2,-1533.31C910.22,-1565.55 900.05,-1631.31 897.58,-1647.24"/>
+</g>
+<!-- h_e&#45;&gt;e_91_center -->
+<g id="edge337" class="edge">
+<title>h_e&#45;&gt;e_91_center</title>
+<path fill="none" stroke="black" d="M929.5,-1501.22C968.18,-1453.84 1092.2,-1301.94 1113.22,-1276.18"/>
+</g>
+<!-- e_5_center&#45;&gt;h_c -->
+<g id="edge21" class="edge">
+<title>e_5_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M642.01,-1572.71C669.21,-1546.19 832.53,-1387.01 890.78,-1330.22"/>
+<polygon fill="black" stroke="black" points="893.56,-1332.4 898.28,-1322.91 888.68,-1327.39 893.56,-1332.4"/>
+</g>
+<!-- e_5_center&#45;&gt;ac_c -->
+<g id="edge20" class="edge">
+<title>e_5_center&#45;&gt;ac_c</title>
+<path fill="none" stroke="black" d="M634.39,-1573.37C611.76,-1554.69 493.04,-1456.68 443.38,-1415.69"/>
+<polygon fill="black" stroke="black" points="445.43,-1412.85 435.49,-1409.18 440.97,-1418.24 445.43,-1412.85"/>
+</g>
+<!-- amp_c -->
+<g id="node23" class="node">
+<title>amp_c</title>
+<ellipse fill="none" stroke="black" cx="426.43" cy="-860.23" rx="18" ry="18"/>
+<text text-anchor="middle" x="426.43" y="-856.53" font-family="Times,serif" font-size="14.00">amp_c</text>
+</g>
+<!-- amp_c&#45;&gt;e_6_center -->
+<g id="edge23" class="edge">
+<title>amp_c&#45;&gt;e_6_center</title>
+<path fill="none" stroke="black" d="M442.75,-868.63C466.44,-880.81 508.9,-902.64 521.59,-909.17"/>
+</g>
+<!-- e_6_center&#45;&gt;adp_c -->
+<g id="edge24" class="edge">
+<title>e_6_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" d="M528.93,-912.87C548.85,-922.72 645.04,-970.3 691.66,-993.37"/>
+<polygon fill="black" stroke="black" points="690.3,-996.6 700.81,-997.89 693.4,-990.32 690.3,-996.6"/>
+</g>
+<!-- akg_c -->
+<g id="node25" class="node">
+<title>akg_c</title>
+<ellipse fill="none" stroke="black" cx="1166.85" cy="-1189.81" rx="18" ry="18"/>
+<text text-anchor="middle" x="1166.85" y="-1186.11" font-family="Times,serif" font-size="14.00">akg_c</text>
+</g>
+<!-- akg_c&#45;&gt;e_7_center -->
+<g id="edge27" class="edge">
+<title>akg_c&#45;&gt;e_7_center</title>
+<path fill="none" stroke="black" d="M1149.81,-1196.6C1130.45,-1204.31 1100.24,-1216.35 1090,-1220.43"/>
+</g>
+<!-- akg_c&#45;&gt;e_54_center -->
+<g id="edge188" class="edge">
+<title>akg_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" d="M1153.82,-1176.86C1135.84,-1159 1104.43,-1127.8 1093.73,-1117.17"/>
+</g>
+<!-- co2_c -->
+<g id="node26" class="node">
+<title>co2_c</title>
+<ellipse fill="none" stroke="black" cx="1132.22" cy="-954.15" rx="18" ry="18"/>
+<text text-anchor="middle" x="1132.22" y="-950.45" font-family="Times,serif" font-size="14.00">co2_c</text>
+</g>
+<!-- co2_c&#45;&gt;e_78_center -->
+<g id="edge280" class="edge">
+<title>co2_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="black" d="M1115.28,-960.42C1104.12,-964.48 1089.17,-969.79 1075.82,-974.08 999.73,-998.5 905.35,-1023.92 885.61,-1029.19"/>
+</g>
+<!-- succoa_c -->
+<g id="node27" class="node">
+<title>succoa_c</title>
+<ellipse fill="none" stroke="black" cx="946.22" cy="-1392.43" rx="18" ry="18"/>
+<text text-anchor="middle" x="946.22" y="-1388.73" font-family="Times,serif" font-size="14.00">succoa_c</text>
+</g>
+<!-- e_7_center&#45;&gt;nadh_c -->
+<g id="edge29" class="edge">
+<title>e_7_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" d="M1082.78,-1219.98C1080.07,-1218.61 1076.12,-1216.62 1071.82,-1214.45"/>
+<polygon fill="black" stroke="black" points="1073.27,-1211.26 1062.76,-1209.89 1070.12,-1217.52 1073.27,-1211.26"/>
+</g>
+<!-- e_7_center&#45;&gt;co2_c -->
+<g id="edge28" class="edge">
+<title>e_7_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" d="M1084.75,-1218.11C1081.66,-1211.05 1075.55,-1195.19 1076.08,-1181.22 1077.16,-1152.61 1089.14,-1147.8 1096.73,-1120.2 1109.92,-1072.24 1121.14,-1015.36 1127.26,-982.16"/>
+<polygon fill="black" stroke="black" points="1130.71,-982.71 1129.06,-972.25 1123.82,-981.46 1130.71,-982.71"/>
+</g>
+<!-- e_7_center&#45;&gt;succoa_c -->
+<g id="edge30" class="edge">
+<title>e_7_center&#45;&gt;succoa_c</title>
+<path fill="none" stroke="black" d="M1084.1,-1225.65C1073.99,-1241.74 1033.17,-1305.38 991.77,-1351.28 984.64,-1359.18 976.14,-1367.18 968.42,-1374"/>
+<polygon fill="black" stroke="black" points="965.74,-1371.69 960.46,-1380.87 970.32,-1376.99 965.74,-1371.69"/>
+</g>
+<!-- akg_e -->
+<g id="node29" class="node">
+<title>akg_e</title>
+<ellipse fill="none" stroke="black" cx="1509.21" cy="-1660.96" rx="18" ry="18"/>
+<text text-anchor="middle" x="1509.21" y="-1657.26" font-family="Times,serif" font-size="14.00">akg_e</text>
+</g>
+<!-- akg_e&#45;&gt;e_8_center -->
+<g id="edge31" class="edge">
+<title>akg_e&#45;&gt;e_8_center</title>
+<path fill="none" stroke="black" d="M1493.72,-1651.17C1436.39,-1614.95 1238.05,-1489.61 1208.92,-1471.21"/>
+</g>
+<!-- e_21_target -->
+<g id="node65" class="node">
+<title>e_21_target</title>
+<ellipse fill="black" stroke="black" cx="1735.18" cy="-1802.02" rx="1.8" ry="1.8"/>
+</g>
+<!-- akg_e&#45;&gt;e_21_target -->
+<g id="edge100" class="edge">
+<title>akg_e&#45;&gt;e_21_target</title>
+<path fill="none" stroke="black" d="M1524.74,-1670.66C1567.93,-1697.62 1688.64,-1772.97 1724.81,-1795.55"/>
+<polygon fill="black" stroke="black" points="1723.04,-1798.57 1733.38,-1800.89 1726.75,-1792.63 1723.04,-1798.57"/>
+</g>
+<!-- e_8_center&#45;&gt;h_c -->
+<g id="edge33" class="edge">
+<title>e_8_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1201.79,-1467.54C1179.41,-1458.65 1055.75,-1408.52 964.05,-1351.22 953.36,-1344.54 942.25,-1336.12 933.02,-1328.64"/>
+<polygon fill="black" stroke="black" points="935.06,-1325.79 925.12,-1322.12 930.6,-1331.19 935.06,-1325.79"/>
+</g>
+<!-- e_8_center&#45;&gt;akg_c -->
+<g id="edge34" class="edge">
+<title>e_8_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="black" d="M1204.85,-1465.41C1201.33,-1439.89 1179.66,-1282.69 1170.71,-1217.79"/>
+<polygon fill="black" stroke="black" points="1174.17,-1217.28 1169.34,-1207.85 1167.24,-1218.23 1174.17,-1217.28"/>
+</g>
+<!-- etoh_c -->
+<g id="node31" class="node">
+<title>etoh_c</title>
+<ellipse fill="none" stroke="black" cx="1289.88" cy="-1612.42" rx="18" ry="18"/>
+<text text-anchor="middle" x="1289.88" y="-1608.72" font-family="Times,serif" font-size="14.00">etoh_c</text>
+</g>
+<!-- etoh_c&#45;&gt;e_9_center -->
+<g id="edge35" class="edge">
+<title>etoh_c&#45;&gt;e_9_center</title>
+<path fill="none" stroke="black" d="M1284.84,-1594.84C1269.92,-1542.83 1226.58,-1391.74 1219.24,-1366.16"/>
+</g>
+<!-- e_9_center&#45;&gt;acald_c -->
+<g id="edge38" class="edge">
+<title>e_9_center&#45;&gt;acald_c</title>
+<path fill="none" stroke="black" d="M1222.03,-1362.65C1246.16,-1363.89 1377.16,-1370.59 1435.58,-1373.58"/>
+<polygon fill="black" stroke="black" points="1435.44,-1377.07 1445.6,-1374.09 1435.8,-1370.08 1435.44,-1377.07"/>
+</g>
+<!-- e_9_center&#45;&gt;nadh_c -->
+<g id="edge37" class="edge">
+<title>e_9_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" d="M1214.67,-1358.64C1202.43,-1345.38 1160.37,-1300.26 1122.97,-1265.75 1113.15,-1256.69 1087.41,-1235.3 1068.48,-1219.72"/>
+<polygon fill="black" stroke="black" points="1070.55,-1216.89 1060.6,-1213.25 1066.1,-1222.3 1070.55,-1216.89"/>
+</g>
+<!-- e_9_center&#45;&gt;h_c -->
+<g id="edge39" class="edge">
+<title>e_9_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1214.52,-1361.68C1192.47,-1357.01 1074.87,-1332.37 977.98,-1317.79 965.47,-1315.91 951.58,-1314.24 939.74,-1312.95"/>
+<polygon fill="black" stroke="black" points="939.85,-1309.44 929.54,-1311.86 939.11,-1316.4 939.85,-1309.44"/>
+</g>
+<!-- pi_c -->
+<g id="node33" class="node">
+<title>pi_c</title>
+<ellipse fill="none" stroke="black" cx="774.55" cy="-1104.66" rx="18" ry="18"/>
+<text text-anchor="middle" x="774.55" y="-1100.96" font-family="Times,serif" font-size="14.00">pi_c</text>
+</g>
+<!-- pi_c&#45;&gt;e_11_center -->
+<g id="edge45" class="edge">
+<title>pi_c&#45;&gt;e_11_center</title>
+<path fill="none" stroke="black" d="M775.68,-1122.88C777.72,-1155.94 781.91,-1223.9 782.93,-1240.38"/>
+</g>
+<!-- pi_c&#45;&gt;e_48_center -->
+<g id="edge150" class="edge">
+<title>pi_c&#45;&gt;e_48_center</title>
+<path fill="none" stroke="black" d="M792.07,-1099.39C806.52,-1094.63 827.22,-1086.81 843.61,-1076.65 903.33,-1039.62 958.93,-972.19 971.89,-955.91"/>
+</g>
+<!-- pi_c&#45;&gt;e_81_center -->
+<g id="edge299" class="edge">
+<title>pi_c&#45;&gt;e_81_center</title>
+<path fill="none" stroke="black" d="M756.7,-1107.12C715.56,-1112.8 616.07,-1126.54 595.54,-1129.38"/>
+</g>
+<!-- e_10_center&#45;&gt;h_c -->
+<g id="edge43" class="edge">
+<title>e_10_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M711.92,-1182.98C732.59,-1196.16 838.91,-1263.91 887.33,-1294.77"/>
+<polygon fill="black" stroke="black" points="885.62,-1297.83 895.94,-1300.25 889.38,-1291.93 885.62,-1297.83"/>
+</g>
+<!-- e_10_center&#45;&gt;adp_c -->
+<g id="edge44" class="edge">
+<title>e_10_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" d="M707.75,-1177.07C705.16,-1161.57 695.84,-1099.88 702.72,-1049.86 703.51,-1044.1 705.01,-1038.08 706.75,-1032.41"/>
+<polygon fill="black" stroke="black" points="710.14,-1033.31 710.04,-1022.71 703.51,-1031.05 710.14,-1033.31"/>
+</g>
+<!-- e_10_center&#45;&gt;pi_c -->
+<g id="edge42" class="edge">
+<title>e_10_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" d="M711.88,-1177.17C717.92,-1170.97 730.63,-1157.76 740.82,-1146.09 746.11,-1140.04 751.68,-1133.34 756.73,-1127.12"/>
+<polygon fill="black" stroke="black" points="759.69,-1129.03 763.24,-1119.05 754.24,-1124.64 759.69,-1129.03"/>
+</g>
+<!-- e_11_center&#45;&gt;h_c -->
+<g id="edge50" class="edge">
+<title>e_11_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M786.86,-1245.94C801.22,-1253.34 854.1,-1280.59 886.16,-1297.1"/>
+<polygon fill="black" stroke="black" points="884.88,-1300.38 895.38,-1301.85 888.09,-1294.16 884.88,-1300.38"/>
+</g>
+<!-- e_11_center&#45;&gt;atp_c -->
+<g id="edge48" class="edge">
+<title>e_11_center&#45;&gt;atp_c</title>
+<path fill="none" stroke="black" d="M781.99,-1240.33C775.74,-1220.36 745.74,-1124.69 730.8,-1077.06"/>
+<polygon fill="black" stroke="black" points="734.11,-1075.89 727.77,-1067.39 727.43,-1077.98 734.11,-1075.89"/>
+</g>
+<!-- e_11_center&#45;&gt;h2o_c -->
+<g id="edge49" class="edge">
+<title>e_11_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="black" d="M781.29,-1240.31C774.92,-1227.64 753.68,-1185.38 739.73,-1157.61"/>
+<polygon fill="black" stroke="black" points="742.75,-1155.82 735.13,-1148.46 736.49,-1158.97 742.75,-1155.82"/>
+</g>
+<!-- nadph_c -->
+<g id="node36" class="node">
+<title>nadph_c</title>
+<ellipse fill="none" stroke="black" cx="1159.98" cy="-1014.03" rx="18" ry="18"/>
+<text text-anchor="middle" x="1159.98" y="-1010.33" font-family="Times,serif" font-size="14.00">nadph_c</text>
+</g>
+<!-- nadph_c&#45;&gt;e_12_center -->
+<g id="edge51" class="edge">
+<title>nadph_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M1143.23,-1007.27C1102.04,-990.7 998.02,-949.16 981.42,-945.6 971.58,-943.49 959.63,-943.49 953.69,-943.66"/>
+</g>
+<!-- nadph_c&#45;&gt;e_54_center -->
+<g id="edge186" class="edge">
+<title>nadph_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" d="M1149.36,-1029.14C1132.85,-1052.62 1101.96,-1096.53 1092.71,-1109.68"/>
+</g>
+<!-- nadph_c&#45;&gt;e_67_center -->
+<g id="edge245" class="edge">
+<title>nadph_c&#45;&gt;e_67_center</title>
+<path fill="none" stroke="black" d="M1175.22,-1024.3C1184.89,-1031.13 1197.42,-1040.58 1207.46,-1050.17 1237.21,-1078.6 1266.83,-1118.9 1275.75,-1131.36"/>
+</g>
+<!-- g3p_c -->
+<g id="node37" class="node">
+<title>g3p_c</title>
+<ellipse fill="none" stroke="black" cx="1021.46" cy="-580.96" rx="18" ry="18"/>
+<text text-anchor="middle" x="1021.46" y="-577.26" font-family="Times,serif" font-size="14.00">g3p_c</text>
+</g>
+<!-- g3p_c&#45;&gt;e_12_center -->
+<g id="edge52" class="edge">
+<title>g3p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M1017.92,-598.95C1004.5,-667.02 957.29,-906.6 950.72,-939.95"/>
+</g>
+<!-- g3p_c&#45;&gt;e_48_center -->
+<g id="edge152" class="edge">
+<title>g3p_c&#45;&gt;e_48_center</title>
+<path fill="none" stroke="black" d="M1019.21,-598.87C1010.49,-668.12 979.28,-916.12 975.17,-948.75"/>
+</g>
+<!-- e_90_center -->
+<g id="node153" class="node">
+<title>e_90_center</title>
+<polygon fill="none" stroke="black" points="1065.65,-407.95 1058.65,-407.95 1058.65,-400.95 1065.65,-400.95 1065.65,-407.95"/>
+</g>
+<!-- g3p_c&#45;&gt;e_90_center -->
+<g id="edge332" class="edge">
+<title>g3p_c&#45;&gt;e_90_center</title>
+<path fill="none" stroke="black" d="M1025.51,-563.39C1034.72,-523.45 1056.77,-427.78 1061.32,-408.05"/>
+</g>
+<!-- glu__L_c -->
+<g id="node38" class="node">
+<title>glu__L_c</title>
+<ellipse fill="none" stroke="black" cx="1150.94" cy="-1115.12" rx="18" ry="18"/>
+<text text-anchor="middle" x="1150.94" y="-1111.42" font-family="Times,serif" font-size="14.00">glu__L_c</text>
+</g>
+<!-- glu__L_c&#45;&gt;e_12_center -->
+<g id="edge53" class="edge">
+<title>glu__L_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M1137.12,-1103.35C1095.97,-1068.27 975.69,-965.75 953.5,-946.84"/>
+</g>
+<!-- glu__L_c&#45;&gt;e_50_center -->
+<g id="edge161" class="edge">
+<title>glu__L_c&#45;&gt;e_50_center</title>
+<path fill="none" stroke="black" d="M1133.87,-1108.47C1091.59,-1092 983.84,-1050.04 962.39,-1041.68"/>
+</g>
+<!-- glu__L_c&#45;&gt;e_52_center -->
+<g id="edge176" class="edge">
+<title>glu__L_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="black" d="M1132.88,-1111.93C1109.63,-1107.81 1070.78,-1100.94 1058.66,-1098.8"/>
+</g>
+<!-- oaa_c -->
+<g id="node39" class="node">
+<title>oaa_c</title>
+<ellipse fill="none" stroke="black" cx="829.84" cy="-1062.7" rx="18" ry="18"/>
+<text text-anchor="middle" x="829.84" y="-1059" font-family="Times,serif" font-size="14.00">oaa_c</text>
+</g>
+<!-- oaa_c&#45;&gt;e_12_center -->
+<g id="edge54" class="edge">
+<title>oaa_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M842.7,-1049.97C869.57,-1023.38 930.5,-963.08 946.21,-947.53"/>
+</g>
+<!-- oaa_c&#45;&gt;e_14_center -->
+<g id="edge77" class="edge">
+<title>oaa_c&#45;&gt;e_14_center</title>
+<path fill="none" stroke="black" d="M819.62,-1077.95C811.62,-1089.51 799.95,-1105.55 788.39,-1118.53 758.66,-1151.93 751,-1160.79 715.09,-1187.43 697.33,-1200.61 673.51,-1212.57 664.57,-1216.88"/>
+</g>
+<!-- oaa_c&#45;&gt;e_79_center -->
+<g id="edge287" class="edge">
+<title>oaa_c&#45;&gt;e_79_center</title>
+<path fill="none" stroke="black" d="M834.24,-1045.12C843.94,-1006.38 866.69,-915.55 871.55,-896.14"/>
+</g>
+<!-- pyr_c -->
+<g id="node40" class="node">
+<title>pyr_c</title>
+<ellipse fill="none" stroke="black" cx="793.8" cy="-978.37" rx="18" ry="18"/>
+<text text-anchor="middle" x="793.8" y="-974.67" font-family="Times,serif" font-size="14.00">pyr_c</text>
+</g>
+<!-- pyr_c&#45;&gt;e_12_center -->
+<g id="edge55" class="edge">
+<title>pyr_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M810.55,-971.36C827,-964.8 852.97,-955.28 876.37,-950.34 902.73,-944.78 935.36,-943.96 946.24,-943.84"/>
+</g>
+<!-- pyr_c&#45;&gt;e_70_center -->
+<g id="edge252" class="edge">
+<title>pyr_c&#45;&gt;e_70_center</title>
+<path fill="none" stroke="black" d="M808.15,-989.47C824.14,-1001.65 850.94,-1021.51 875.19,-1036.88 905.29,-1055.96 943.67,-1075.66 955.46,-1081.61"/>
+</g>
+<!-- pyr_c&#45;&gt;e_72_center -->
+<g id="edge263" class="edge">
+<title>pyr_c&#45;&gt;e_72_center</title>
+<path fill="none" stroke="black" d="M783.82,-993.68C772.5,-1010.93 753.36,-1039.72 736.09,-1063.93 690.78,-1127.45 632.31,-1202.49 618.41,-1220.26"/>
+</g>
+<!-- pyr_c&#45;&gt;e_80_center -->
+<g id="edge292" class="edge">
+<title>pyr_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="black" d="M775.49,-977.28C756.21,-976.97 725.63,-978.93 703.28,-992.05 689.34,-1000.23 674.97,-1013.03 668.31,-1019.24"/>
+</g>
+<!-- e4p_c -->
+<g id="node41" class="node">
+<title>e4p_c</title>
+<ellipse fill="none" stroke="black" cx="1070.84" cy="-611.61" rx="18" ry="18"/>
+<text text-anchor="middle" x="1070.84" y="-607.91" font-family="Times,serif" font-size="14.00">e4p_c</text>
+</g>
+<!-- e4p_c&#45;&gt;e_12_center -->
+<g id="edge56" class="edge">
+<title>e4p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M1064.68,-628.54C1041.78,-691.48 962.3,-909.89 951.24,-940.3"/>
+</g>
+<!-- e_93_center -->
+<g id="node156" class="node">
+<title>e_93_center</title>
+<polygon fill="none" stroke="black" points="1126.15,-449.18 1119.15,-449.18 1119.15,-442.18 1126.15,-442.18 1126.15,-449.18"/>
+</g>
+<!-- e4p_c&#45;&gt;e_93_center -->
+<g id="edge345" class="edge">
+<title>e4p_c&#45;&gt;e_93_center</title>
+<path fill="none" stroke="black" d="M1076.29,-594.16C1088.13,-556.22 1115.65,-468.08 1121.53,-449.26"/>
+</g>
+<!-- r5p_c -->
+<g id="node42" class="node">
+<title>r5p_c</title>
+<ellipse fill="none" stroke="black" cx="1154.37" cy="-628.38" rx="18" ry="18"/>
+<text text-anchor="middle" x="1154.37" y="-624.68" font-family="Times,serif" font-size="14.00">r5p_c</text>
+</g>
+<!-- r5p_c&#45;&gt;e_12_center -->
+<g id="edge57" class="edge">
+<title>r5p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M1144.51,-643.59C1106.71,-701.92 972.15,-909.57 952.39,-940.07"/>
+</g>
+<!-- ru5p__D_c -->
+<g id="node122" class="node">
+<title>ru5p__D_c</title>
+<ellipse fill="none" stroke="black" cx="1362.9" cy="-542.19" rx="18" ry="18"/>
+<text text-anchor="middle" x="1362.9" y="-538.49" font-family="Times,serif" font-size="14.00">ru5p__D_c</text>
+</g>
+<!-- r5p_c&#45;&gt;ru5p__D_c -->
+<g id="edge312" class="edge">
+<title>r5p_c&#45;&gt;ru5p__D_c</title>
+<path fill="none" stroke="black" d="M1171.08,-621.47C1207.3,-606.5 1293.29,-570.96 1336.76,-552.99"/>
+<polygon fill="black" stroke="black" points="1338.2,-556.18 1346.11,-549.13 1335.53,-549.71 1338.2,-556.18"/>
+</g>
+<!-- e_92_center -->
+<g id="node155" class="node">
+<title>e_92_center</title>
+<polygon fill="none" stroke="black" points="1189.53,-381.22 1182.53,-381.22 1182.53,-374.22 1189.53,-374.22 1189.53,-381.22"/>
+</g>
+<!-- r5p_c&#45;&gt;e_92_center -->
+<g id="edge341" class="edge">
+<title>r5p_c&#45;&gt;e_92_center</title>
+<path fill="none" stroke="black" d="M1156.64,-610.35C1163.28,-557.81 1182.34,-406.95 1185.56,-381.41"/>
+</g>
+<!-- gln__L_c -->
+<g id="node43" class="node">
+<title>gln__L_c</title>
+<ellipse fill="none" stroke="black" cx="876.28" cy="-969.94" rx="18" ry="18"/>
+<text text-anchor="middle" x="876.28" y="-966.24" font-family="Times,serif" font-size="14.00">gln__L_c</text>
+</g>
+<!-- gln__L_c&#45;&gt;e_12_center -->
+<g id="edge59" class="edge">
+<title>gln__L_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M893.37,-963.88C910.88,-957.67 936.85,-948.47 946.33,-945.11"/>
+</g>
+<!-- gln__L_c&#45;&gt;e_53_center -->
+<g id="edge182" class="edge">
+<title>gln__L_c&#45;&gt;e_53_center</title>
+<path fill="none" stroke="black" d="M894.46,-970.47C928.69,-971.46 1000.81,-973.55 1018.3,-974.06"/>
+</g>
+<!-- gln__L_c&#45;&gt;e_54_center -->
+<g id="edge187" class="edge">
+<title>gln__L_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" d="M891.94,-979.61C924.22,-999.67 1000.27,-1047.6 1061.63,-1091.44 1070.78,-1097.97 1081.1,-1106.22 1086.43,-1110.54"/>
+</g>
+<!-- g6p_c -->
+<g id="node44" class="node">
+<title>g6p_c</title>
+<ellipse fill="none" stroke="black" cx="920.29" cy="-740.82" rx="18" ry="18"/>
+<text text-anchor="middle" x="920.29" y="-737.12" font-family="Times,serif" font-size="14.00">g6p_c</text>
+</g>
+<!-- f6p_c -->
+<g id="node46" class="node">
+<title>f6p_c</title>
+<ellipse fill="none" stroke="black" cx="934.92" cy="-649.11" rx="18" ry="18"/>
+<text text-anchor="middle" x="934.92" y="-645.41" font-family="Times,serif" font-size="14.00">f6p_c</text>
+</g>
+<!-- g6p_c&#45;&gt;f6p_c -->
+<g id="edge266" class="edge">
+<title>g6p_c&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" d="M923.18,-722.7C925.24,-709.76 928.06,-692.1 930.42,-677.33"/>
+<polygon fill="black" stroke="black" points="933.92,-677.61 932.04,-667.19 927,-676.51 933.92,-677.61"/>
+</g>
+<!-- g6p_c&#45;&gt;e_12_center -->
+<g id="edge60" class="edge">
+<title>g6p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M922.92,-758.83C929.48,-803.66 946.22,-918.21 949.42,-940.15"/>
+</g>
+<!-- e_47_center -->
+<g id="node110" class="node">
+<title>e_47_center</title>
+<polygon fill="none" stroke="black" points="1072.62,-970.88 1065.62,-970.88 1065.62,-963.88 1072.62,-963.88 1072.62,-970.88"/>
+</g>
+<!-- g6p_c&#45;&gt;e_47_center -->
+<g id="edge146" class="edge">
+<title>g6p_c&#45;&gt;e_47_center</title>
+<path fill="none" stroke="black" d="M930.29,-756.03C960.66,-802.27 1050.75,-939.41 1066.7,-963.68"/>
+</g>
+<!-- pep_c -->
+<g id="node45" class="node">
+<title>pep_c</title>
+<ellipse fill="none" stroke="black" cx="744.99" cy="-829.05" rx="18" ry="18"/>
+<text text-anchor="middle" x="744.99" y="-825.35" font-family="Times,serif" font-size="14.00">pep_c</text>
+</g>
+<!-- pep_c&#45;&gt;e_12_center -->
+<g id="edge61" class="edge">
+<title>pep_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M760.51,-838.32C783.4,-851.92 827.61,-877.97 865.77,-899.15 896.73,-916.34 934.76,-936 946.4,-941.99"/>
+</g>
+<!-- e_44_center -->
+<g id="node105" class="node">
+<title>e_44_center</title>
+<polygon fill="none" stroke="black" points="738.79,-600 731.79,-600 731.79,-593 738.79,-593 738.79,-600"/>
+</g>
+<!-- pep_c&#45;&gt;e_44_center -->
+<g id="edge135" class="edge">
+<title>pep_c&#45;&gt;e_44_center</title>
+<path fill="none" stroke="black" d="M744.82,-810.86C744.54,-786.55 743.85,-742.15 742.21,-704.27 740.45,-663.44 736.67,-614 735.59,-600.22"/>
+</g>
+<!-- e_49_center -->
+<g id="node113" class="node">
+<title>e_49_center</title>
+<polygon fill="none" stroke="black" points="684.17,-637.74 677.17,-637.74 677.17,-630.74 684.17,-630.74 684.17,-637.74"/>
+</g>
+<!-- pep_c&#45;&gt;e_49_center -->
+<g id="edge157" class="edge">
+<title>pep_c&#45;&gt;e_49_center</title>
+<path fill="none" stroke="black" d="M739.06,-811.71C730.86,-787.63 715.62,-742.68 703.01,-704.22 694.67,-678.77 684.98,-647.99 681.76,-637.74"/>
+</g>
+<!-- pep_c&#45;&gt;e_78_center -->
+<g id="edge281" class="edge">
+<title>pep_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="black" d="M755.28,-844.17C784,-886.38 863.98,-1003.87 879.32,-1026.41"/>
+</g>
+<!-- pep_c&#45;&gt;e_82_center -->
+<g id="edge302" class="edge">
+<title>pep_c&#45;&gt;e_82_center</title>
+<path fill="none" stroke="black" d="M747.69,-846.87C754.76,-893.33 773.43,-1016.12 776.86,-1038.74"/>
+</g>
+<!-- f6p_c&#45;&gt;e_12_center -->
+<g id="edge64" class="edge">
+<title>f6p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M935.93,-667.39C936.96,-685.91 938.57,-715.38 939.89,-740.88 944.08,-821.55 948.83,-920.29 949.79,-940.22"/>
+</g>
+<!-- f6p_c&#45;&gt;e_71_center -->
+<g id="edge258" class="edge">
+<title>f6p_c&#45;&gt;e_71_center</title>
+<path fill="none" stroke="black" d="M928.47,-666.05C908.78,-717.77 850.23,-871.62 840.31,-897.68"/>
+</g>
+<!-- 3pg_c -->
+<g id="node47" class="node">
+<title>3pg_c</title>
+<ellipse fill="none" stroke="black" cx="722.61" cy="-704.24" rx="18" ry="18"/>
+<text text-anchor="middle" x="722.61" y="-700.54" font-family="Times,serif" font-size="14.00">3pg_c</text>
+</g>
+<!-- 3pg_c&#45;&gt;e_12_center -->
+<g id="edge65" class="edge">
+<title>3pg_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M735.16,-717.47C778.72,-763.37 922.11,-914.48 946.44,-940.11"/>
+</g>
+<!-- 3pg_c&#45;&gt;e_74_center -->
+<g id="edge267" class="edge">
+<title>3pg_c&#45;&gt;e_74_center</title>
+<path fill="none" stroke="black" d="M713.58,-720.35C699.74,-745.04 674.12,-790.76 666.81,-803.79"/>
+</g>
+<!-- nadp_c -->
+<g id="node48" class="node">
+<title>nadp_c</title>
+<ellipse fill="none" stroke="black" cx="1193.56" cy="-1063.99" rx="18" ry="18"/>
+<text text-anchor="middle" x="1193.56" y="-1060.29" font-family="Times,serif" font-size="14.00">nadp_c</text>
+</g>
+<!-- nadp_c&#45;&gt;e_47_center -->
+<g id="edge145" class="edge">
+<title>nadp_c&#45;&gt;e_47_center</title>
+<path fill="none" stroke="black" d="M1178.96,-1052.96C1169.54,-1045.83 1157.04,-1036.31 1146.05,-1027.82 1117.57,-1005.79 1083.5,-978.79 1072.64,-970.17"/>
+</g>
+<!-- nadp_c&#45;&gt;e_52_center -->
+<g id="edge174" class="edge">
+<title>nadp_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="black" d="M1176,-1068.31C1143.36,-1076.35 1075.15,-1093.16 1058.6,-1097.23"/>
+</g>
+<!-- e_56_center -->
+<g id="node123" class="node">
+<title>e_56_center</title>
+<polygon fill="none" stroke="black" points="1306.83,-829.22 1299.83,-829.22 1299.83,-822.22 1306.83,-822.22 1306.83,-829.22"/>
+</g>
+<!-- nadp_c&#45;&gt;e_56_center -->
+<g id="edge195" class="edge">
+<title>nadp_c&#45;&gt;e_56_center</title>
+<path fill="none" stroke="black" d="M1197.91,-1046.12C1205.36,-1017.18 1222.12,-958.74 1246.08,-913.5 1264.3,-879.09 1292.07,-840.87 1300.69,-829.25"/>
+</g>
+<!-- nadp_c&#45;&gt;e_58_center -->
+<g id="edge201" class="edge">
+<title>nadp_c&#45;&gt;e_58_center</title>
+<path fill="none" stroke="black" d="M1178.03,-1073.57C1159.1,-1085.12 1126.01,-1104.88 1096.73,-1120.2 1060.67,-1139.06 1015.51,-1158.87 1002.27,-1164.6"/>
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+<!-- e_65_center -->
+<g id="node132" class="node">
+<title>e_65_center</title>
+<polygon fill="none" stroke="black" points="1040.46,-1064.75 1033.46,-1064.75 1033.46,-1057.75 1040.46,-1057.75 1040.46,-1064.75"/>
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+<!-- nadp_c&#45;&gt;e_65_center -->
+<g id="edge235" class="edge">
+<title>nadp_c&#45;&gt;e_65_center</title>
+<path fill="none" stroke="black" d="M1175.29,-1063.67C1138.82,-1063.03 1058.93,-1061.64 1040.71,-1061.32"/>
+</g>
+<!-- nadp_c&#45;&gt;e_91_center -->
+<g id="edge335" class="edge">
+<title>nadp_c&#45;&gt;e_91_center</title>
+<path fill="none" stroke="black" d="M1187.23,-1081.05C1170.51,-1126.17 1125.81,-1246.7 1117.58,-1268.91"/>
+</g>
+<!-- e_12_center&#45;&gt;coa_c -->
+<g id="edge72" class="edge">
+<title>e_12_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" d="M948.6,-947.57C939.4,-973.01 885.86,-1121 863.61,-1182.49"/>
+<polygon fill="black" stroke="black" points="860.19,-1181.66 860.07,-1192.26 866.77,-1184.04 860.19,-1181.66"/>
+</g>
+<!-- e_12_center&#45;&gt;nadh_c -->
+<g id="edge68" class="edge">
+<title>e_12_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" d="M951.32,-947.46C960.55,-972.12 1014.12,-1115.25 1036.56,-1175.24"/>
+<polygon fill="black" stroke="black" points="1033.35,-1176.64 1040.13,-1184.78 1039.91,-1174.19 1033.35,-1176.64"/>
+</g>
+<!-- e_12_center&#45;&gt;h_c -->
+<g id="edge70" class="edge">
+<title>e_12_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M949.58,-947.44C946.3,-978.6 922.8,-1201.94 914.39,-1281.81"/>
+<polygon fill="black" stroke="black" points="910.88,-1281.78 913.31,-1292.09 917.84,-1282.51 910.88,-1281.78"/>
+</g>
+<!-- e_12_center&#45;&gt;adp_c -->
+<g id="edge73" class="edge">
+<title>e_12_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" d="M946.22,-943.76C935.3,-943.67 902.55,-943.99 876.37,-950.34 835.16,-960.34 834.83,-987.66 793.7,-997.97 778.09,-1001.88 760.24,-1003.88 745.69,-1004.9"/>
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+<!-- e_12_center&#45;&gt;akg_c -->
+<g id="edge71" class="edge">
+<title>e_12_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="black" d="M953.2,-947.34C969.09,-964.58 1040.16,-1041.95 1096.73,-1106.8 1114.58,-1127.26 1134.52,-1150.95 1148.56,-1167.77"/>
+<polygon fill="black" stroke="black" points="1146.23,-1170.45 1155.32,-1175.89 1151.61,-1165.97 1146.23,-1170.45"/>
+</g>
+<!-- e_12_center&#45;&gt;pi_c -->
+<g id="edge69" class="edge">
+<title>e_12_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" d="M946.37,-946.11C930.12,-956.57 862.24,-1001.37 816.08,-1048.74 806.68,-1058.39 797.6,-1070.23 790.34,-1080.52"/>
+<polygon fill="black" stroke="black" points="787.24,-1078.85 784.46,-1089.08 793.01,-1082.81 787.24,-1078.85"/>
+</g>
+<!-- e_12_center&#45;&gt;nadp_c -->
+<g id="edge67" class="edge">
+<title>e_12_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="black" d="M953.61,-947.39C957.11,-950.68 962.63,-955.57 968.02,-959 1035.47,-1001.97 1123.33,-1037.7 1166.8,-1054.19"/>
+<polygon fill="black" stroke="black" points="1165.77,-1057.54 1176.36,-1057.78 1168.23,-1050.99 1165.77,-1057.54"/>
+</g>
+<!-- co2_e -->
+<g id="node50" class="node">
+<title>co2_e</title>
+<ellipse fill="none" stroke="black" cx="1465.37" cy="-728.13" rx="18" ry="18"/>
+<text text-anchor="middle" x="1465.37" y="-724.43" font-family="Times,serif" font-size="14.00">co2_e</text>
+</g>
+<!-- co2_e&#45;&gt;co2_c -->
+<g id="edge74" class="edge">
+<title>co2_e&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" d="M1450.19,-738.43C1397.18,-774.39 1220.07,-894.55 1155.78,-938.16"/>
+<polygon fill="black" stroke="black" points="1153.8,-935.28 1147.49,-943.79 1157.73,-941.07 1153.8,-935.28"/>
+</g>
+<!-- e_22_target -->
+<g id="node66" class="node">
+<title>e_22_target</title>
+<ellipse fill="black" stroke="black" cx="1684.99" cy="-570.23" rx="1.8" ry="1.8"/>
+</g>
+<!-- co2_e&#45;&gt;e_22_target -->
+<g id="edge101" class="edge">
+<title>co2_e&#45;&gt;e_22_target</title>
+<path fill="none" stroke="black" d="M1480.12,-717.53C1521.78,-687.58 1639.56,-602.89 1674.87,-577.51"/>
+<polygon fill="black" stroke="black" points="1677.15,-580.18 1683.23,-571.5 1673.07,-574.49 1677.15,-580.18"/>
+</g>
+<!-- e_14_center&#45;&gt;coa_c -->
+<g id="edge79" class="edge">
+<title>e_14_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" d="M664.65,-1218.4C684.32,-1217.45 777.85,-1212.94 825.65,-1210.64"/>
+<polygon fill="black" stroke="black" points="825.84,-1214.13 835.66,-1210.16 825.5,-1207.14 825.84,-1214.13"/>
+</g>
+<!-- e_14_center&#45;&gt;h_c -->
+<g id="edge80" class="edge">
+<title>e_14_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M664.51,-1219.87C688.29,-1228.57 825.6,-1278.75 884.55,-1300.29"/>
+<polygon fill="black" stroke="black" points="883.68,-1303.7 894.27,-1303.85 886.08,-1297.13 883.68,-1303.7"/>
+</g>
+<!-- e_14_center&#45;&gt;cit_c -->
+<g id="edge78" class="edge">
+<title>e_14_center&#45;&gt;cit_c</title>
+<path fill="none" stroke="black" d="M657.42,-1218.34C648.96,-1217.82 626.98,-1216.66 608.64,-1217.46 531.74,-1220.86 441.4,-1230.33 396.58,-1235.4"/>
+<polygon fill="black" stroke="black" points="396,-1231.94 386.46,-1236.56 396.79,-1238.9 396,-1231.94"/>
+</g>
+<!-- o2_c -->
+<g id="node52" class="node">
+<title>o2_c</title>
+<ellipse fill="none" stroke="black" cx="558.29" cy="-1940.84" rx="18" ry="18"/>
+<text text-anchor="middle" x="558.29" y="-1937.14" font-family="Times,serif" font-size="14.00">o2_c</text>
+</g>
+<!-- o2_c&#45;&gt;e_15_center -->
+<g id="edge81" class="edge">
+<title>o2_c&#45;&gt;e_15_center</title>
+<path fill="none" stroke="black" d="M565.98,-1924.34C597.95,-1855.69 719.45,-1594.79 735.45,-1560.44"/>
+</g>
+<!-- q8h2_c -->
+<g id="node53" class="node">
+<title>q8h2_c</title>
+<ellipse fill="none" stroke="black" cx="795.16" cy="-1726.84" rx="18" ry="18"/>
+<text text-anchor="middle" x="795.16" y="-1723.14" font-family="Times,serif" font-size="14.00">q8h2_c</text>
+</g>
+<!-- q8h2_c&#45;&gt;e_15_center -->
+<g id="edge82" class="edge">
+<title>q8h2_c&#45;&gt;e_15_center</title>
+<path fill="none" stroke="black" d="M789.29,-1709.59C776.16,-1671.06 745.09,-1579.89 738.45,-1560.4"/>
+</g>
+<!-- e_43_center -->
+<g id="node104" class="node">
+<title>e_43_center</title>
+<polygon fill="none" stroke="black" points="720.64,-1865.62 713.64,-1865.62 713.64,-1858.62 720.64,-1858.62 720.64,-1865.62"/>
+</g>
+<!-- q8h2_c&#45;&gt;e_43_center -->
+<g id="edge130" class="edge">
+<title>q8h2_c&#45;&gt;e_43_center</title>
+<path fill="none" stroke="black" d="M786.06,-1742.62C768.05,-1773.85 728.79,-1841.92 719.26,-1858.45"/>
+</g>
+<!-- q8_c -->
+<g id="node54" class="node">
+<title>q8_c</title>
+<ellipse fill="none" stroke="black" cx="845.94" cy="-1731.79" rx="18" ry="18"/>
+<text text-anchor="middle" x="845.94" y="-1728.09" font-family="Times,serif" font-size="14.00">q8_c</text>
+</g>
+<!-- q8_c&#45;&gt;e_66_center -->
+<g id="edge239" class="edge">
+<title>q8_c&#45;&gt;e_66_center</title>
+<path fill="none" stroke="black" d="M853.61,-1715.37C877.87,-1663.45 952.02,-1504.74 964.02,-1479.05"/>
+</g>
+<!-- e_88_center -->
+<g id="node150" class="node">
+<title>e_88_center</title>
+<polygon fill="none" stroke="black" points="763.01,-1882.78 756.01,-1882.78 756.01,-1875.78 763.01,-1875.78 763.01,-1882.78"/>
+</g>
+<!-- q8_c&#45;&gt;e_88_center -->
+<g id="edge321" class="edge">
+<title>q8_c&#45;&gt;e_88_center</title>
+<path fill="none" stroke="black" d="M831.85,-1743.51C825.45,-1749.33 818.12,-1756.74 812.72,-1764.4 784.85,-1803.92 765.58,-1860.36 760.72,-1875.45"/>
+</g>
+<!-- e_15_center&#45;&gt;h2o_c -->
+<g id="edge86" class="edge">
+<title>e_15_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="black" d="M737.1,-1553.03C736.27,-1518.45 729.79,-1249.23 727.65,-1160.49"/>
+<polygon fill="black" stroke="black" points="731.15,-1160.27 727.41,-1150.36 724.15,-1160.44 731.15,-1160.27"/>
+</g>
+<!-- e_15_center&#45;&gt;h_e -->
+<g id="edge85" class="edge">
+<title>e_15_center&#45;&gt;h_e</title>
+<path fill="none" stroke="black" d="M740.97,-1555.83C759.93,-1551.49 845.65,-1531.88 890.47,-1521.62"/>
+<polygon fill="black" stroke="black" points="891.44,-1524.99 900.41,-1519.35 889.88,-1518.16 891.44,-1524.99"/>
+</g>
+<!-- e_15_center&#45;&gt;q8_c -->
+<g id="edge84" class="edge">
+<title>e_15_center&#45;&gt;q8_c</title>
+<path fill="none" stroke="black" d="M739.46,-1560.36C751.11,-1579.11 804.64,-1665.3 831.08,-1707.87"/>
+<polygon fill="black" stroke="black" points="828.19,-1709.84 836.44,-1716.49 834.13,-1706.15 828.19,-1709.84"/>
+</g>
+<!-- lac__D_e -->
+<g id="node56" class="node">
+<title>lac__D_e</title>
+<ellipse fill="none" stroke="black" cx="1328.12" cy="-1933.24" rx="18" ry="18"/>
+<text text-anchor="middle" x="1328.12" y="-1929.54" font-family="Times,serif" font-size="14.00">lac__D_e</text>
+</g>
+<!-- lac__D_e&#45;&gt;e_16_center -->
+<g id="edge87" class="edge">
+<title>lac__D_e&#45;&gt;e_16_center</title>
+<path fill="none" stroke="black" d="M1317.78,-1918.07C1279.5,-1861.92 1147.06,-1667.62 1127.61,-1639.09"/>
+</g>
+<!-- e_32_target -->
+<g id="node83" class="node">
+<title>e_32_target</title>
+<ellipse fill="black" stroke="black" cx="1480.69" cy="-2153.52" rx="1.8" ry="1.8"/>
+</g>
+<!-- lac__D_e&#45;&gt;e_32_target -->
+<g id="edge111" class="edge">
+<title>lac__D_e&#45;&gt;e_32_target</title>
+<path fill="none" stroke="black" d="M1338.61,-1948.38C1367.77,-1990.49 1449.27,-2108.16 1473.69,-2143.42"/>
+<polygon fill="black" stroke="black" points="1470.9,-2145.54 1479.47,-2151.77 1476.65,-2141.55 1470.9,-2145.54"/>
+</g>
+<!-- lac__D_c -->
+<g id="node57" class="node">
+<title>lac__D_c</title>
+<ellipse fill="none" stroke="black" cx="1151.88" cy="-1489.97" rx="18" ry="18"/>
+<text text-anchor="middle" x="1151.88" y="-1486.27" font-family="Times,serif" font-size="14.00">lac__D_c</text>
+</g>
+<!-- lac__D_c&#45;&gt;e_60_center -->
+<g id="edge209" class="edge">
+<title>lac__D_c&#45;&gt;e_60_center</title>
+<path fill="none" stroke="black" d="M1141.63,-1474.72C1110.02,-1427.66 1015.11,-1286.36 998.32,-1261.35"/>
+</g>
+<!-- e_16_center&#45;&gt;h_c -->
+<g id="edge90" class="edge">
+<title>e_16_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1122.95,-1631.92C1108.63,-1608.77 1029.03,-1480.52 960.11,-1378.6 949.75,-1363.28 937.71,-1346.34 928.2,-1333.15"/>
+<polygon fill="black" stroke="black" points="930.76,-1330.72 922.06,-1324.67 925.09,-1334.82 930.76,-1330.72"/>
+</g>
+<!-- e_16_center&#45;&gt;lac__D_c -->
+<g id="edge89" class="edge">
+<title>e_16_center&#45;&gt;lac__D_c</title>
+<path fill="none" stroke="black" d="M1125.88,-1631.98C1128.71,-1616.52 1140,-1554.83 1146.74,-1518.03"/>
+<polygon fill="black" stroke="black" points="1150.23,-1518.4 1148.59,-1507.94 1143.34,-1517.14 1150.23,-1518.4"/>
+</g>
+<!-- 2pg_c -->
+<g id="node59" class="node">
+<title>2pg_c</title>
+<ellipse fill="none" stroke="black" cx="497.28" cy="-600.44" rx="18" ry="18"/>
+<text text-anchor="middle" x="497.28" y="-596.74" font-family="Times,serif" font-size="14.00">2pg_c</text>
+</g>
+<!-- 2pg_c&#45;&gt;3pg_c -->
+<g id="edge275" class="edge">
+<title>2pg_c&#45;&gt;3pg_c</title>
+<path fill="none" stroke="black" d="M513.85,-608.07C552.75,-625.99 650.17,-670.87 696.86,-692.38"/>
+<polygon fill="black" stroke="black" points="695.47,-695.59 706.02,-696.6 698.4,-689.24 695.47,-695.59"/>
+</g>
+<!-- e_17_center -->
+<g id="node60" class="node">
+<title>e_17_center</title>
+<polygon fill="none" stroke="black" points="571.44,-825.54 564.44,-825.54 564.44,-818.54 571.44,-818.54 571.44,-825.54"/>
+</g>
+<!-- 2pg_c&#45;&gt;e_17_center -->
+<g id="edge91" class="edge">
+<title>2pg_c&#45;&gt;e_17_center</title>
+<path fill="none" stroke="black" d="M502.82,-617.83C517.92,-665.17 559.14,-794.42 566.73,-818.24"/>
+</g>
+<!-- e_17_center&#45;&gt;h2o_c -->
+<g id="edge93" class="edge">
+<title>e_17_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="black" d="M569.97,-825.72C580.7,-845.2 631.92,-938.52 671.21,-1016.18 686.75,-1046.9 703.77,-1082.65 714.87,-1106.27"/>
+<polygon fill="black" stroke="black" points="711.83,-1108.02 719.24,-1115.59 718.17,-1105.05 711.83,-1108.02"/>
+</g>
+<!-- e_17_center&#45;&gt;pep_c -->
+<g id="edge92" class="edge">
+<title>e_17_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="black" d="M571.64,-822.19C590.04,-822.92 672.56,-826.18 716.78,-827.93"/>
+<polygon fill="black" stroke="black" points="716.75,-831.44 726.88,-828.33 717.03,-824.44 716.75,-831.44"/>
+</g>
+<!-- etoh_e -->
+<g id="node61" class="node">
+<title>etoh_e</title>
+<ellipse fill="none" stroke="black" cx="1127.45" cy="-2036.97" rx="18" ry="18"/>
+<text text-anchor="middle" x="1127.45" y="-2033.27" font-family="Times,serif" font-size="14.00">etoh_e</text>
+</g>
+<!-- etoh_e&#45;&gt;e_18_center -->
+<g id="edge95" class="edge">
+<title>etoh_e&#45;&gt;e_18_center</title>
+<path fill="none" stroke="black" d="M1124.92,-2019.03C1115.34,-1951.17 1081.63,-1712.31 1076.93,-1679.06"/>
+</g>
+<!-- e_23_target -->
+<g id="node67" class="node">
+<title>e_23_target</title>
+<ellipse fill="black" stroke="black" cx="1179.89" cy="-2295.78" rx="1.8" ry="1.8"/>
+</g>
+<!-- etoh_e&#45;&gt;e_23_target -->
+<g id="edge102" class="edge">
+<title>etoh_e&#45;&gt;e_23_target</title>
+<path fill="none" stroke="black" d="M1131.06,-2054.76C1141.08,-2104.22 1169.09,-2242.48 1177.48,-2283.9"/>
+<polygon fill="black" stroke="black" points="1174.05,-2284.61 1179.47,-2293.71 1180.92,-2283.22 1174.05,-2284.61"/>
+</g>
+<!-- e_18_center&#45;&gt;h_c -->
+<g id="edge97" class="edge">
+<title>e_18_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1075.35,-1671.52C1068.01,-1645.9 1022.63,-1491.92 960.11,-1378.6 951.09,-1362.25 938.92,-1345.14 929,-1332.1"/>
+<polygon fill="black" stroke="black" points="931.76,-1329.94 922.87,-1324.18 926.22,-1334.23 931.76,-1329.94"/>
+</g>
+<!-- e_18_center&#45;&gt;etoh_c -->
+<g id="edge96" class="edge">
+<title>e_18_center&#45;&gt;etoh_c</title>
+<path fill="none" stroke="black" d="M1080.1,-1674.12C1101.54,-1667.81 1210.59,-1635.74 1262.44,-1620.49"/>
+<polygon fill="black" stroke="black" points="1263.68,-1623.77 1272.29,-1617.59 1261.71,-1617.06 1263.68,-1623.77"/>
+</g>
+<!-- e_24_target -->
+<g id="node68" class="node">
+<title>e_24_target</title>
+<ellipse fill="black" stroke="black" cx="66.67" cy="-1786.44" rx="1.8" ry="1.8"/>
+</g>
+<!-- for_e -->
+<g id="node69" class="node">
+<title>for_e</title>
+<ellipse fill="none" stroke="black" cx="300.68" cy="-1655.94" rx="18" ry="18"/>
+<text text-anchor="middle" x="300.68" y="-1652.24" font-family="Times,serif" font-size="14.00">for_e</text>
+</g>
+<!-- for_e&#45;&gt;e_24_target -->
+<g id="edge103" class="edge">
+<title>for_e&#45;&gt;e_24_target</title>
+<path fill="none" stroke="black" d="M284.6,-1664.91C239.87,-1689.85 114.86,-1759.57 77.4,-1780.46"/>
+<polygon fill="black" stroke="black" points="75.56,-1777.48 68.53,-1785.4 78.97,-1783.59 75.56,-1777.48"/>
+</g>
+<!-- for_e&#45;&gt;e_41_center -->
+<g id="edge125" class="edge">
+<title>for_e&#45;&gt;e_41_center</title>
+<path fill="none" stroke="black" d="M317.42,-1648.91C378.31,-1623.3 586.09,-1535.94 616.6,-1523.11"/>
+</g>
+<!-- e_25_target -->
+<g id="node70" class="node">
+<title>e_25_target</title>
+<ellipse fill="black" stroke="black" cx="573.51" cy="-1.74" rx="1.8" ry="1.8"/>
+</g>
+<!-- fru_e -->
+<g id="node71" class="node">
+<title>fru_e</title>
+<ellipse fill="none" stroke="black" cx="639.15" cy="-248.46" rx="18" ry="18"/>
+<text text-anchor="middle" x="639.15" y="-244.76" font-family="Times,serif" font-size="14.00">fru_e</text>
+</g>
+<!-- fru_e&#45;&gt;e_25_target -->
+<g id="edge104" class="edge">
+<title>fru_e&#45;&gt;e_25_target</title>
+<path fill="none" stroke="black" d="M634.43,-230.71C621.75,-183.07 587.21,-53.24 576.63,-13.47"/>
+<polygon fill="black" stroke="black" points="579.98,-12.45 574.03,-3.69 573.21,-14.25 579.98,-12.45"/>
+</g>
+<!-- fru_e&#45;&gt;e_44_center -->
+<g id="edge134" class="edge">
+<title>fru_e&#45;&gt;e_44_center</title>
+<path fill="none" stroke="black" d="M644.05,-266.2C662.27,-332.13 725.48,-560.96 734.27,-592.81"/>
+</g>
+<!-- e_26_target -->
+<g id="node72" class="node">
+<title>e_26_target</title>
+<ellipse fill="black" stroke="black" cx="1276.35" cy="-2268.64" rx="1.8" ry="1.8"/>
+</g>
+<!-- fum_e -->
+<g id="node73" class="node">
+<title>fum_e</title>
+<ellipse fill="none" stroke="black" cx="1172.91" cy="-2025.98" rx="18" ry="18"/>
+<text text-anchor="middle" x="1172.91" y="-2022.28" font-family="Times,serif" font-size="14.00">fum_e</text>
+</g>
+<!-- fum_e&#45;&gt;e_26_target -->
+<g id="edge105" class="edge">
+<title>fum_e&#45;&gt;e_26_target</title>
+<path fill="none" stroke="black" d="M1180.02,-2042.66C1199.79,-2089.04 1255.05,-2218.67 1271.6,-2257.51"/>
+<polygon fill="black" stroke="black" points="1268.38,-2258.88 1275.52,-2266.71 1274.82,-2256.14 1268.38,-2258.88"/>
+</g>
+<!-- fum_e&#45;&gt;e_46_center -->
+<g id="edge142" class="edge">
+<title>fum_e&#45;&gt;e_46_center</title>
+<path fill="none" stroke="black" d="M1164.63,-2009.76C1133.43,-1948.65 1023.97,-1734.23 1007.89,-1702.74"/>
+</g>
+<!-- e_27_target -->
+<g id="node74" class="node">
+<title>e_27_target</title>
+<ellipse fill="black" stroke="black" cx="368.59" cy="-97.54" rx="1.8" ry="1.8"/>
+</g>
+<!-- glc__D_e -->
+<g id="node75" class="node">
+<title>glc__D_e</title>
+<ellipse fill="none" stroke="black" cx="497.17" cy="-318.79" rx="18" ry="18"/>
+<text text-anchor="middle" x="497.17" y="-315.09" font-family="Times,serif" font-size="14.00">glc__D_e</text>
+</g>
+<!-- glc__D_e&#45;&gt;e_27_target -->
+<g id="edge106" class="edge">
+<title>glc__D_e&#45;&gt;e_27_target</title>
+<path fill="none" stroke="black" d="M487.92,-302.88C463.09,-260.15 395.43,-143.73 374.7,-108.07"/>
+<polygon fill="black" stroke="black" points="377.66,-106.18 369.61,-99.29 371.6,-109.7 377.66,-106.18"/>
+</g>
+<!-- glc__D_e&#45;&gt;e_49_center -->
+<g id="edge156" class="edge">
+<title>glc__D_e&#45;&gt;e_49_center</title>
+<path fill="none" stroke="black" d="M506.27,-334.43C540.55,-393.36 660.83,-600.14 678.49,-630.51"/>
+</g>
+<!-- e_28_target -->
+<g id="node76" class="node">
+<title>e_28_target</title>
+<ellipse fill="black" stroke="black" cx="50.77" cy="-721.47" rx="1.8" ry="1.8"/>
+</g>
+<!-- gln__L_e -->
+<g id="node77" class="node">
+<title>gln__L_e</title>
+<ellipse fill="none" stroke="black" cx="285.16" cy="-852.78" rx="18" ry="18"/>
+<text text-anchor="middle" x="285.16" y="-849.08" font-family="Times,serif" font-size="14.00">gln__L_e</text>
+</g>
+<!-- gln__L_e&#45;&gt;e_28_target -->
+<g id="edge107" class="edge">
+<title>gln__L_e&#45;&gt;e_28_target</title>
+<path fill="none" stroke="black" d="M269.42,-843.96C224.96,-819.06 99.25,-748.63 61.57,-727.52"/>
+<polygon fill="black" stroke="black" points="63.08,-724.36 52.65,-722.53 59.66,-730.47 63.08,-724.36"/>
+</g>
+<!-- gln__L_e&#45;&gt;e_51_center -->
+<g id="edge168" class="edge">
+<title>gln__L_e&#45;&gt;e_51_center</title>
+<path fill="none" stroke="black" d="M301.05,-861.64C363.36,-896.36 589.05,-1022.16 620.49,-1039.67"/>
+</g>
+<!-- e_29_target -->
+<g id="node78" class="node">
+<title>e_29_target</title>
+<ellipse fill="black" stroke="black" cx="1800.55" cy="-1618.66" rx="1.8" ry="1.8"/>
+</g>
+<!-- glu__L_e -->
+<g id="node79" class="node">
+<title>glu__L_e</title>
+<ellipse fill="none" stroke="black" cx="1551.02" cy="-1527.4" rx="18" ry="18"/>
+<text text-anchor="middle" x="1551.02" y="-1523.7" font-family="Times,serif" font-size="14.00">glu__L_e</text>
+</g>
+<!-- glu__L_e&#45;&gt;e_29_target -->
+<g id="edge108" class="edge">
+<title>glu__L_e&#45;&gt;e_29_target</title>
+<path fill="none" stroke="black" d="M1568.17,-1533.67C1615.86,-1551.12 1749.16,-1599.87 1789.1,-1614.48"/>
+<polygon fill="black" stroke="black" points="1787.97,-1617.79 1798.56,-1617.94 1790.37,-1611.21 1787.97,-1617.79"/>
+</g>
+<!-- glu__L_e&#45;&gt;e_55_center -->
+<g id="edge192" class="edge">
+<title>glu__L_e&#45;&gt;e_55_center</title>
+<path fill="none" stroke="black" d="M1533.78,-1521.23C1469.7,-1498.28 1247.32,-1418.66 1216.37,-1407.57"/>
+</g>
+<!-- e_31_target -->
+<g id="node81" class="node">
+<title>e_31_target</title>
+<ellipse fill="black" stroke="black" cx="44.62" cy="-934.97" rx="1.8" ry="1.8"/>
+</g>
+<!-- h2o_e -->
+<g id="node82" class="node">
+<title>h2o_e</title>
+<ellipse fill="none" stroke="black" cx="313.99" cy="-1001.71" rx="18" ry="18"/>
+<text text-anchor="middle" x="313.99" y="-998.01" font-family="Times,serif" font-size="14.00">h2o_e</text>
+</g>
+<!-- h2o_e&#45;&gt;h2o_c -->
+<g id="edge200" class="edge">
+<title>h2o_e&#45;&gt;h2o_c</title>
+<path fill="none" stroke="black" d="M331.21,-1007.15C395.49,-1027.47 621.74,-1098.97 700.05,-1123.72"/>
+<polygon fill="black" stroke="black" points="699.09,-1127.08 709.68,-1126.76 701.2,-1120.41 699.09,-1127.08"/>
+</g>
+<!-- h2o_e&#45;&gt;e_31_target -->
+<g id="edge110" class="edge">
+<title>h2o_e&#45;&gt;e_31_target</title>
+<path fill="none" stroke="black" d="M296.32,-997.33C245.4,-984.72 99.32,-948.52 56.53,-937.92"/>
+<polygon fill="black" stroke="black" points="57.34,-934.52 46.79,-935.51 55.65,-941.31 57.34,-934.52"/>
+</g>
+<!-- e_33_target -->
+<g id="node84" class="node">
+<title>e_33_target</title>
+<ellipse fill="black" stroke="black" cx="1568.27" cy="-1997.95" rx="1.8" ry="1.8"/>
+</g>
+<!-- mal__L_e -->
+<g id="node85" class="node">
+<title>mal__L_e</title>
+<ellipse fill="none" stroke="black" cx="1379.92" cy="-1814.92" rx="18" ry="18"/>
+<text text-anchor="middle" x="1379.92" y="-1811.22" font-family="Times,serif" font-size="14.00">mal__L_e</text>
+</g>
+<!-- mal__L_e&#45;&gt;e_33_target -->
+<g id="edge112" class="edge">
+<title>mal__L_e&#45;&gt;e_33_target</title>
+<path fill="none" stroke="black" d="M1392.86,-1827.5C1428.71,-1862.33 1528.61,-1959.41 1559.23,-1989.17"/>
+<polygon fill="black" stroke="black" points="1557.16,-1992.03 1566.77,-1996.49 1562.04,-1987.01 1557.16,-1992.03"/>
+</g>
+<!-- mal__L_e&#45;&gt;e_62_center -->
+<g id="edge221" class="edge">
+<title>mal__L_e&#45;&gt;e_62_center</title>
+<path fill="none" stroke="black" d="M1367,-1802.17C1318.75,-1754.54 1150.46,-1588.44 1123.17,-1561.51"/>
+</g>
+<!-- e_34_target -->
+<g id="node86" class="node">
+<title>e_34_target</title>
+<ellipse fill="black" stroke="black" cx="1865.81" cy="-666.02" rx="1.8" ry="1.8"/>
+</g>
+<!-- nh4_e -->
+<g id="node87" class="node">
+<title>nh4_e</title>
+<ellipse fill="none" stroke="black" cx="1628.87" cy="-770.95" rx="18" ry="18"/>
+<text text-anchor="middle" x="1628.87" y="-767.25" font-family="Times,serif" font-size="14.00">nh4_e</text>
+</g>
+<!-- nh4_e&#45;&gt;e_34_target -->
+<g id="edge113" class="edge">
+<title>nh4_e&#45;&gt;e_34_target</title>
+<path fill="none" stroke="black" d="M1645.53,-763.57C1690.96,-743.45 1816.13,-688.02 1854.49,-671.03"/>
+<polygon fill="black" stroke="black" points="1856.2,-674.1 1863.93,-666.85 1853.37,-667.7 1856.2,-674.1"/>
+</g>
+<!-- nh4_c -->
+<g id="node114" class="node">
+<title>nh4_c</title>
+<ellipse fill="none" stroke="black" cx="1259.89" cy="-927.4" rx="18" ry="18"/>
+<text text-anchor="middle" x="1259.89" y="-923.7" font-family="Times,serif" font-size="14.00">nh4_c</text>
+</g>
+<!-- nh4_e&#45;&gt;nh4_c -->
+<g id="edge249" class="edge">
+<title>nh4_e&#45;&gt;nh4_c</title>
+<path fill="none" stroke="black" d="M1612.06,-778.08C1553.47,-802.92 1357.99,-885.81 1286.43,-916.15"/>
+<polygon fill="black" stroke="black" points="1284.64,-913.11 1276.8,-920.23 1287.37,-919.55 1284.64,-913.11"/>
+</g>
+<!-- e_35_target -->
+<g id="node88" class="node">
+<title>e_35_target</title>
+<ellipse fill="black" stroke="black" cx="299.66" cy="-2500.92" rx="1.8" ry="1.8"/>
+</g>
+<!-- o2_e -->
+<g id="node89" class="node">
+<title>o2_e</title>
+<ellipse fill="none" stroke="black" cx="405.25" cy="-2275.53" rx="18" ry="18"/>
+<text text-anchor="middle" x="405.25" y="-2271.83" font-family="Times,serif" font-size="14.00">o2_e</text>
+</g>
+<!-- o2_e&#45;&gt;o2_c -->
+<g id="edge250" class="edge">
+<title>o2_e&#45;&gt;o2_c</title>
+<path fill="none" stroke="black" d="M412.84,-2258.94C437.62,-2204.74 516.31,-2032.65 546.42,-1966.81"/>
+<polygon fill="black" stroke="black" points="549.68,-1968.09 550.66,-1957.54 543.32,-1965.18 549.68,-1968.09"/>
+</g>
+<!-- o2_e&#45;&gt;e_35_target -->
+<g id="edge114" class="edge">
+<title>o2_e&#45;&gt;e_35_target</title>
+<path fill="none" stroke="black" d="M397.49,-2292.11C377.04,-2335.76 322.09,-2453.05 304.89,-2489.77"/>
+<polygon fill="black" stroke="black" points="301.57,-2488.61 300.49,-2499.15 307.91,-2491.58 301.57,-2488.61"/>
+</g>
+<!-- e_36_target -->
+<g id="node90" class="node">
+<title>e_36_target</title>
+<ellipse fill="black" stroke="black" cx="191.03" cy="-1872.16" rx="1.8" ry="1.8"/>
+</g>
+<!-- pi_e -->
+<g id="node91" class="node">
+<title>pi_e</title>
+<ellipse fill="none" stroke="black" cx="399.26" cy="-1694.73" rx="18" ry="18"/>
+<text text-anchor="middle" x="399.26" y="-1691.03" font-family="Times,serif" font-size="14.00">pi_e</text>
+</g>
+<!-- pi_e&#45;&gt;e_36_target -->
+<g id="edge115" class="edge">
+<title>pi_e&#45;&gt;e_36_target</title>
+<path fill="none" stroke="black" d="M385.27,-1706.65C345.78,-1740.3 234.1,-1835.46 200.62,-1863.98"/>
+<polygon fill="black" stroke="black" points="198.04,-1861.59 192.69,-1870.74 202.58,-1866.92 198.04,-1861.59"/>
+</g>
+<!-- pi_e&#45;&gt;e_77_center -->
+<g id="edge277" class="edge">
+<title>pi_e&#45;&gt;e_77_center</title>
+<path fill="none" stroke="black" d="M412.85,-1682.62C464.74,-1636.37 648.88,-1472.27 677.33,-1446.92"/>
+</g>
+<!-- e_37_target -->
+<g id="node92" class="node">
+<title>e_37_target</title>
+<ellipse fill="black" stroke="black" cx="1.92" cy="-1481.45" rx="1.8" ry="1.8"/>
+</g>
+<!-- pyr_e -->
+<g id="node93" class="node">
+<title>pyr_e</title>
+<ellipse fill="none" stroke="black" cx="271.08" cy="-1416.72" rx="18" ry="18"/>
+<text text-anchor="middle" x="271.08" y="-1413.02" font-family="Times,serif" font-size="14.00">pyr_e</text>
+</g>
+<!-- pyr_e&#45;&gt;e_37_target -->
+<g id="edge116" class="edge">
+<title>pyr_e&#45;&gt;e_37_target</title>
+<path fill="none" stroke="black" d="M253.42,-1420.96C202.54,-1433.2 56.57,-1468.31 13.82,-1478.59"/>
+<polygon fill="black" stroke="black" points="12.99,-1475.19 4.08,-1480.93 14.63,-1481.99 12.99,-1475.19"/>
+</g>
+<!-- pyr_e&#45;&gt;e_83_center -->
+<g id="edge307" class="edge">
+<title>pyr_e&#45;&gt;e_83_center</title>
+<path fill="none" stroke="black" d="M288.58,-1412.19C357.44,-1394.35 607.64,-1329.53 640.57,-1321"/>
+</g>
+<!-- e_38_target -->
+<g id="node94" class="node">
+<title>e_38_target</title>
+<ellipse fill="black" stroke="black" cx="867.98" cy="-2203.58" rx="1.8" ry="1.8"/>
+</g>
+<!-- succ_e -->
+<g id="node95" class="node">
+<title>succ_e</title>
+<ellipse fill="none" stroke="black" cx="880.7" cy="-1935.02" rx="18" ry="18"/>
+<text text-anchor="middle" x="880.7" y="-1931.32" font-family="Times,serif" font-size="14.00">succ_e</text>
+</g>
+<!-- succ_e&#45;&gt;e_38_target -->
+<g id="edge117" class="edge">
+<title>succ_e&#45;&gt;e_38_target</title>
+<path fill="none" stroke="black" d="M879.84,-1953.05C877.43,-2003.99 870.61,-2148.03 868.56,-2191.2"/>
+<polygon fill="black" stroke="black" points="865.06,-2191.27 868.08,-2201.43 872.05,-2191.6 865.06,-2191.27"/>
+</g>
+<!-- succ_e&#45;&gt;e_86_center -->
+<g id="edge313" class="edge">
+<title>succ_e&#45;&gt;e_86_center</title>
+<path fill="none" stroke="black" d="M879.79,-1916.92C876.86,-1858.56 867.78,-1677.39 866.37,-1649.44"/>
+</g>
+<!-- fdp_c -->
+<g id="node96" class="node">
+<title>fdp_c</title>
+<ellipse fill="none" stroke="black" cx="837.15" cy="-608.74" rx="18" ry="18"/>
+<text text-anchor="middle" x="837.15" y="-605.04" font-family="Times,serif" font-size="14.00">fdp_c</text>
+</g>
+<!-- e_39_center -->
+<g id="node98" class="node">
+<title>e_39_center</title>
+<polygon fill="none" stroke="black" points="934.69,-385.26 927.69,-385.26 927.69,-378.26 934.69,-378.26 934.69,-385.26"/>
+</g>
+<!-- fdp_c&#45;&gt;e_39_center -->
+<g id="edge118" class="edge">
+<title>fdp_c&#45;&gt;e_39_center</title>
+<path fill="none" stroke="black" d="M844.07,-592.05C863.83,-544.34 919.79,-409.28 929.69,-385.39"/>
+</g>
+<!-- fdp_c&#45;&gt;e_40_center -->
+<g id="edge122" class="edge">
+<title>fdp_c&#45;&gt;e_40_center</title>
+<path fill="none" stroke="black" d="M833.1,-626.48C828.2,-648.05 819.77,-685.58 813.03,-717.87 803.8,-762.13 793.58,-816.1 790.89,-830.41"/>
+</g>
+<!-- dhap_c -->
+<g id="node97" class="node">
+<title>dhap_c</title>
+<ellipse fill="none" stroke="black" cx="1017.71" cy="-277.36" rx="18" ry="18"/>
+<text text-anchor="middle" x="1017.71" y="-273.66" font-family="Times,serif" font-size="14.00">dhap_c</text>
+</g>
+<!-- dhap_c&#45;&gt;g3p_c -->
+<g id="edge349" class="edge">
+<title>dhap_c&#45;&gt;g3p_c</title>
+<path fill="none" stroke="black" d="M1017.94,-295.45C1018.56,-346.26 1020.35,-490.66 1021.11,-552.4"/>
+<polygon fill="black" stroke="black" points="1017.61,-552.63 1021.24,-562.59 1024.61,-552.54 1017.61,-552.63"/>
+</g>
+<!-- e_39_center&#45;&gt;g3p_c -->
+<g id="edge120" class="edge">
+<title>e_39_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="black" d="M932.92,-385.56C942.33,-406.35 987.96,-507.04 1009.79,-555.2"/>
+<polygon fill="black" stroke="black" points="1006.62,-556.69 1013.94,-564.36 1013,-553.8 1006.62,-556.69"/>
+</g>
+<!-- e_39_center&#45;&gt;dhap_c -->
+<g id="edge119" class="edge">
+<title>e_39_center&#45;&gt;dhap_c</title>
+<path fill="none" stroke="black" d="M934.48,-377.8C945.01,-365.09 978.45,-324.74 999.6,-299.22"/>
+<polygon fill="black" stroke="black" points="1002.31,-301.44 1005.99,-291.51 996.92,-296.97 1002.31,-301.44"/>
+</g>
+<!-- e_40_center&#45;&gt;pi_c -->
+<g id="edge124" class="edge">
+<title>e_40_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" d="M789.55,-837.56C785.85,-857.98 767.74,-962.88 770.71,-1049.04 771.02,-1057.98 771.61,-1067.72 772.23,-1076.5"/>
+<polygon fill="black" stroke="black" points="768.75,-1076.93 772.99,-1086.64 775.73,-1076.41 768.75,-1076.93"/>
+</g>
+<!-- e_40_center&#45;&gt;f6p_c -->
+<g id="edge123" class="edge">
+<title>e_40_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" d="M792.97,-830.5C808.25,-810.98 882.95,-715.51 917.43,-671.46"/>
+<polygon fill="black" stroke="black" points="920.35,-673.41 923.76,-663.37 914.84,-669.09 920.35,-673.41"/>
+</g>
+<!-- for_c -->
+<g id="node100" class="node">
+<title>for_c</title>
+<ellipse fill="none" stroke="black" cx="426.89" cy="-1463.4" rx="18" ry="18"/>
+<text text-anchor="middle" x="426.89" y="-1459.7" font-family="Times,serif" font-size="14.00">for_c</text>
+</g>
+<!-- for_c&#45;&gt;for_e -->
+<g id="edge129" class="edge">
+<title>for_c&#45;&gt;for_e</title>
+<path fill="none" stroke="black" d="M416.99,-1478.51C395.11,-1511.89 342.51,-1592.13 316.21,-1632.26"/>
+<polygon fill="black" stroke="black" points="313.27,-1630.36 310.72,-1640.64 319.13,-1634.19 313.27,-1630.36"/>
+</g>
+<!-- e_41_center&#45;&gt;h_c -->
+<g id="edge128" class="edge">
+<title>e_41_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M624.03,-1518.86C651.49,-1498.91 825.15,-1372.77 888.41,-1326.83"/>
+<polygon fill="black" stroke="black" points="890.54,-1329.6 896.57,-1320.9 886.42,-1323.94 890.54,-1329.6"/>
+</g>
+<!-- e_41_center&#45;&gt;for_c -->
+<g id="edge127" class="edge">
+<title>e_41_center&#45;&gt;for_c</title>
+<path fill="none" stroke="black" d="M616.66,-1520.42C596.75,-1514.44 501.37,-1485.78 453.88,-1471.51"/>
+<polygon fill="black" stroke="black" points="454.83,-1468.14 444.25,-1468.61 452.82,-1474.84 454.83,-1468.14"/>
+</g>
+<!-- fum_c -->
+<g id="node102" class="node">
+<title>fum_c</title>
+<ellipse fill="none" stroke="black" cx="826.44" cy="-1778.39" rx="18" ry="18"/>
+<text text-anchor="middle" x="826.44" y="-1774.69" font-family="Times,serif" font-size="14.00">fum_c</text>
+</g>
+<!-- fum_c&#45;&gt;e_43_center -->
+<g id="edge131" class="edge">
+<title>fum_c&#45;&gt;e_43_center</title>
+<path fill="none" stroke="black" d="M812.15,-1789.34C786.69,-1808.84 734.82,-1848.57 720.74,-1859.36"/>
+</g>
+<!-- fum_c&#45;&gt;e_45_center -->
+<g id="edge139" class="edge">
+<title>fum_c&#45;&gt;e_45_center</title>
+<path fill="none" stroke="black" d="M825.09,-1760.43C820.48,-1699.33 805.58,-1501.7 803.39,-1472.7"/>
+</g>
+<!-- succ_c -->
+<g id="node103" class="node">
+<title>succ_c</title>
+<ellipse fill="none" stroke="black" cx="717.27" cy="-1656.99" rx="18" ry="18"/>
+<text text-anchor="middle" x="717.27" y="-1653.29" font-family="Times,serif" font-size="14.00">succ_c</text>
+</g>
+<!-- succ_c&#45;&gt;e_87_center -->
+<g id="edge318" class="edge">
+<title>succ_c&#45;&gt;e_87_center</title>
+<path fill="none" stroke="black" d="M735.49,-1656.71C764.56,-1656.22 823.22,-1654.99 872.89,-1652.5 880.11,-1652.14 888.53,-1651.49 893.28,-1651.1"/>
+</g>
+<!-- succ_c&#45;&gt;e_88_center -->
+<g id="edge322" class="edge">
+<title>succ_c&#45;&gt;e_88_center</title>
+<path fill="none" stroke="black" d="M720.66,-1674.8C729.74,-1722.61 754.27,-1851.7 758.79,-1875.49"/>
+</g>
+<!-- succ_c&#45;&gt;e_89_center -->
+<g id="edge327" class="edge">
+<title>succ_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="black" d="M718.63,-1638.82C723.69,-1571.27 741.26,-1336.88 743.7,-1304.25"/>
+</g>
+<!-- e_43_center&#45;&gt;q8_c -->
+<g id="edge132" class="edge">
+<title>e_43_center&#45;&gt;q8_c</title>
+<path fill="none" stroke="black" d="M720.76,-1858.36C733.36,-1845.3 776.5,-1800.68 812.72,-1764.4 816.86,-1760.25 821.32,-1755.84 825.58,-1751.64"/>
+<polygon fill="black" stroke="black" points="828.25,-1753.93 832.94,-1744.43 823.35,-1748.93 828.25,-1753.93"/>
+</g>
+<!-- e_43_center&#45;&gt;succ_c -->
+<g id="edge133" class="edge">
+<title>e_43_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" d="M717.14,-1858.56C717.15,-1838.24 717.22,-1736.05 717.25,-1685.45"/>
+<polygon fill="black" stroke="black" points="720.75,-1685.21 717.26,-1675.2 713.75,-1685.2 720.75,-1685.21"/>
+</g>
+<!-- e_44_center&#45;&gt;pyr_c -->
+<g id="edge137" class="edge">
+<title>e_44_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" d="M735.87,-600.28C740.88,-632.97 777,-868.68 789.53,-950.49"/>
+<polygon fill="black" stroke="black" points="786.1,-951.19 791.07,-960.55 793.02,-950.13 786.1,-951.19"/>
+</g>
+<!-- e_44_center&#45;&gt;f6p_c -->
+<g id="edge136" class="edge">
+<title>e_44_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" d="M739.14,-597.85C752.53,-602.5 798.42,-618.2 837.12,-628.34 860.61,-634.49 887.62,-640.12 907.3,-643.96"/>
+<polygon fill="black" stroke="black" points="906.65,-647.4 917.14,-645.85 907.98,-640.53 906.65,-647.4"/>
+</g>
+<!-- mal__L_c -->
+<g id="node106" class="node">
+<title>mal__L_c</title>
+<ellipse fill="none" stroke="black" cx="977.94" cy="-1337.39" rx="18" ry="18"/>
+<text text-anchor="middle" x="977.94" y="-1333.69" font-family="Times,serif" font-size="14.00">mal__L_c</text>
+</g>
+<!-- mal__L_c&#45;&gt;e_63_center -->
+<g id="edge224" class="edge">
+<title>mal__L_c&#45;&gt;e_63_center</title>
+<path fill="none" stroke="black" d="M973.32,-1319.85C966.03,-1292.09 952.26,-1239.72 948.53,-1225.54"/>
+</g>
+<!-- mal__L_c&#45;&gt;e_64_center -->
+<g id="edge229" class="edge">
+<title>mal__L_c&#45;&gt;e_64_center</title>
+<path fill="none" stroke="black" d="M979.24,-1319.2C981.57,-1287 986.68,-1217.85 991.77,-1159.54 993.4,-1140.77 995.67,-1118.32 996.56,-1109.68"/>
+</g>
+<!-- mal__L_c&#45;&gt;e_65_center -->
+<g id="edge234" class="edge">
+<title>mal__L_c&#45;&gt;e_65_center</title>
+<path fill="none" stroke="black" d="M979.62,-1319.39C981.4,-1301.82 984.59,-1274.36 989.06,-1250.85 1003.5,-1174.8 1030.21,-1083.82 1035.88,-1064.83"/>
+</g>
+<!-- e_45_center&#45;&gt;mal__L_c -->
+<g id="edge140" class="edge">
+<title>e_45_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" d="M806.78,-1466.39C825.68,-1452.14 913.18,-1386.19 955.24,-1354.5"/>
+<polygon fill="black" stroke="black" points="957.6,-1357.1 963.48,-1348.28 953.39,-1351.51 957.6,-1357.1"/>
+</g>
+<!-- e_46_center&#45;&gt;h_c -->
+<g id="edge143" class="edge">
+<title>e_46_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1004.87,-1695.25C997.65,-1670.03 954.43,-1517.94 926.62,-1392.38 922.66,-1374.52 918.92,-1354.32 916.14,-1338.41"/>
+<polygon fill="black" stroke="black" points="919.52,-1337.42 914.37,-1328.16 912.62,-1338.61 919.52,-1337.42"/>
+</g>
+<!-- e_46_center&#45;&gt;fum_c -->
+<g id="edge144" class="edge">
+<title>e_46_center&#45;&gt;fum_c</title>
+<path fill="none" stroke="black" d="M1002.17,-1700.53C983.12,-1708.97 896.25,-1747.46 852.21,-1766.98"/>
+<polygon fill="black" stroke="black" points="850.72,-1763.81 843,-1771.06 853.56,-1770.21 850.72,-1763.81"/>
+</g>
+<!-- 6pgl_c -->
+<g id="node109" class="node">
+<title>6pgl_c</title>
+<ellipse fill="none" stroke="black" cx="1228.21" cy="-853.67" rx="18" ry="18"/>
+<text text-anchor="middle" x="1228.21" y="-849.97" font-family="Times,serif" font-size="14.00">6pgl_c</text>
+</g>
+<!-- 6pgl_c&#45;&gt;e_75_center -->
+<g id="edge271" class="edge">
+<title>6pgl_c&#45;&gt;e_75_center</title>
+<path fill="none" stroke="black" d="M1218.24,-869.01C1203.41,-891.47 1174.23,-934.32 1145.99,-968.09 1123.44,-995.06 1092.72,-1024.37 1082.41,-1034.04"/>
+</g>
+<!-- e_47_center&#45;&gt;h_c -->
+<g id="edge148" class="edge">
+<title>e_47_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1067.48,-971.03C1062.11,-982.99 1044.57,-1022.11 1030.26,-1054.55 996.19,-1131.78 990.83,-1152.53 954.28,-1228.62 945.05,-1247.83 933.8,-1269.14 925.15,-1285.14"/>
+<polygon fill="black" stroke="black" points="921.84,-1283.9 920.14,-1294.36 927.99,-1287.25 921.84,-1283.9"/>
+</g>
+<!-- e_47_center&#45;&gt;nadph_c -->
+<g id="edge149" class="edge">
+<title>e_47_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" d="M1073.03,-969.38C1083.5,-974.76 1112.9,-989.86 1134.63,-1001.01"/>
+<polygon fill="black" stroke="black" points="1133.19,-1004.21 1143.69,-1005.67 1136.39,-997.98 1133.19,-1004.21"/>
+</g>
+<!-- e_47_center&#45;&gt;6pgl_c -->
+<g id="edge147" class="edge">
+<title>e_47_center&#45;&gt;6pgl_c</title>
+<path fill="none" stroke="black" d="M1072.74,-964.79C1090.13,-952.36 1165.77,-898.3 1204.77,-870.43"/>
+<polygon fill="black" stroke="black" points="1207.29,-872.93 1213.39,-864.26 1203.22,-867.23 1207.29,-872.93"/>
+</g>
+<!-- 13dpg_c -->
+<g id="node111" class="node">
+<title>13dpg_c</title>
+<ellipse fill="none" stroke="black" cx="832.63" cy="-717.99" rx="18" ry="18"/>
+<text text-anchor="middle" x="832.63" y="-714.29" font-family="Times,serif" font-size="14.00">13dpg_c</text>
+</g>
+<!-- e_48_center&#45;&gt;nadh_c -->
+<g id="edge154" class="edge">
+<title>e_48_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" d="M975.74,-955.83C982.53,-979.45 1021.69,-1115.59 1038.64,-1174.51"/>
+<polygon fill="black" stroke="black" points="1035.32,-1175.6 1041.44,-1184.24 1042.04,-1173.67 1035.32,-1175.6"/>
+</g>
+<!-- e_48_center&#45;&gt;h_c -->
+<g id="edge155" class="edge">
+<title>e_48_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M973.51,-955.98C969.78,-967.38 958.4,-1003.15 951.94,-1033.52 932.8,-1123.52 919.78,-1231.92 914.32,-1282.1"/>
+<polygon fill="black" stroke="black" points="910.82,-1281.86 913.24,-1292.18 917.78,-1282.61 910.82,-1281.86"/>
+</g>
+<!-- e_48_center&#45;&gt;13dpg_c -->
+<g id="edge153" class="edge">
+<title>e_48_center&#45;&gt;13dpg_c</title>
+<path fill="none" stroke="black" d="M972.49,-948.62C958.31,-925.23 880.27,-796.54 847.32,-742.21"/>
+<polygon fill="black" stroke="black" points="850.25,-740.29 842.08,-733.56 844.27,-743.92 850.25,-740.29"/>
+</g>
+<!-- e_49_center&#45;&gt;pyr_c -->
+<g id="edge159" class="edge">
+<title>e_49_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" d="M681.06,-637.83C683.45,-658.49 696.92,-764.21 731.02,-842.8 747.76,-881.37 768.47,-925.45 781.41,-952.6"/>
+<polygon fill="black" stroke="black" points="778.34,-954.28 785.81,-961.79 784.65,-951.26 778.34,-954.28"/>
+</g>
+<!-- e_49_center&#45;&gt;g6p_c -->
+<g id="edge158" class="edge">
+<title>e_49_center&#45;&gt;g6p_c</title>
+<path fill="none" stroke="black" d="M684.32,-635.69C702.22,-642.78 782.36,-674.76 846.58,-704.21 862.83,-711.67 880.8,-720.58 894.93,-727.74"/>
+<polygon fill="black" stroke="black" points="893.54,-730.96 904.04,-732.38 896.72,-724.72 893.54,-730.96"/>
+</g>
+<!-- nh4_c&#45;&gt;e_50_center -->
+<g id="edge162" class="edge">
+<title>nh4_c&#45;&gt;e_50_center</title>
+<path fill="none" stroke="black" d="M1242.83,-933.79C1184.08,-955.79 992.13,-1027.68 962.5,-1038.78"/>
+</g>
+<!-- e_50_center&#45;&gt;h_c -->
+<g id="edge163" class="edge">
+<title>e_50_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M957.97,-1044.04C953.47,-1069.78 927.36,-1218.95 916.33,-1282"/>
+<polygon fill="black" stroke="black" points="912.85,-1281.58 914.58,-1292.04 919.75,-1282.79 912.85,-1281.58"/>
+</g>
+<!-- e_50_center&#45;&gt;adp_c -->
+<g id="edge166" class="edge">
+<title>e_50_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" d="M954.88,-1039.14C944.45,-1036.17 914.23,-1027.84 888.59,-1023.48 838.54,-1014.98 779.52,-1010.05 745.39,-1007.69"/>
+<polygon fill="black" stroke="black" points="745.44,-1004.18 735.23,-1007.01 744.98,-1011.17 745.44,-1004.18"/>
+</g>
+<!-- e_50_center&#45;&gt;pi_c -->
+<g id="edge164" class="edge">
+<title>e_50_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" d="M955.13,-1041.45C936.32,-1048.03 846.69,-1079.41 801.18,-1095.34"/>
+<polygon fill="black" stroke="black" points="799.95,-1092.06 791.67,-1098.67 802.26,-1098.67 799.95,-1092.06"/>
+</g>
+<!-- e_50_center&#45;&gt;gln__L_c -->
+<g id="edge165" class="edge">
+<title>e_50_center&#45;&gt;gln__L_c</title>
+<path fill="none" stroke="black" d="M955.1,-1037.2C945.36,-1028.89 917.55,-1005.16 897.73,-988.25"/>
+<polygon fill="black" stroke="black" points="899.94,-985.53 890.06,-981.7 895.4,-990.86 899.94,-985.53"/>
+</g>
+<!-- e_51_center&#45;&gt;h_c -->
+<g id="edge170" class="edge">
+<title>e_51_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M626.98,-1045.51C637.61,-1059.57 676.13,-1109.64 713.1,-1146.07 772.33,-1204.43 850.23,-1264.62 888.37,-1293.15"/>
+<polygon fill="black" stroke="black" points="886.63,-1296.22 896.74,-1299.38 890.81,-1290.6 886.63,-1296.22"/>
+</g>
+<!-- e_51_center&#45;&gt;adp_c -->
+<g id="edge173" class="edge">
+<title>e_51_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" d="M627.64,-1041.08C635.57,-1039.61 655.44,-1035.59 671.21,-1029.58 678.19,-1026.93 685.49,-1023.5 692.15,-1020.08"/>
+<polygon fill="black" stroke="black" points="694.19,-1022.96 701.37,-1015.17 690.89,-1016.78 694.19,-1022.96"/>
+</g>
+<!-- e_51_center&#45;&gt;pi_c -->
+<g id="edge171" class="edge">
+<title>e_51_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" d="M627.85,-1043.26C644.25,-1050.13 711,-1078.06 748.56,-1093.78"/>
+<polygon fill="black" stroke="black" points="747.29,-1097.04 757.87,-1097.68 750,-1090.59 747.29,-1097.04"/>
+</g>
+<!-- e_51_center&#45;&gt;gln__L_c -->
+<g id="edge172" class="edge">
+<title>e_51_center&#45;&gt;gln__L_c</title>
+<path fill="none" stroke="black" d="M627.72,-1041.3C640.2,-1039.83 682.81,-1034.44 717.05,-1025.55 764.87,-1013.13 818.83,-992.92 850.06,-980.59"/>
+<polygon fill="black" stroke="black" points="851.37,-983.84 859.36,-976.88 848.78,-977.33 851.37,-983.84"/>
+</g>
+<!-- e_52_center&#45;&gt;h_c -->
+<g id="edge179" class="edge">
+<title>e_52_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1052.46,-1101.88C1045.24,-1112.84 1023.48,-1145.78 1005.17,-1172.94 978.22,-1212.9 946.5,-1259.15 927.73,-1286.44"/>
+<polygon fill="black" stroke="black" points="924.67,-1284.71 921.88,-1294.93 930.43,-1288.68 924.67,-1284.71"/>
+</g>
+<!-- e_52_center&#45;&gt;akg_c -->
+<g id="edge180" class="edge">
+<title>e_52_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="black" d="M1058.66,-1101.19C1071.86,-1112 1117.1,-1149.05 1144.73,-1171.68"/>
+<polygon fill="black" stroke="black" points="1142.73,-1174.57 1152.68,-1178.2 1147.16,-1169.16 1142.73,-1174.57"/>
+</g>
+<!-- e_52_center&#45;&gt;nadph_c -->
+<g id="edge178" class="edge">
+<title>e_52_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" d="M1058.92,-1094.94C1071.65,-1084.75 1111.96,-1052.48 1137.66,-1031.91"/>
+<polygon fill="black" stroke="black" points="1140.13,-1034.41 1145.75,-1025.43 1135.76,-1028.95 1140.13,-1034.41"/>
+</g>
+<!-- e_52_center&#45;&gt;nh4_c -->
+<g id="edge177" class="edge">
+<title>e_52_center&#45;&gt;nh4_c</title>
+<path fill="none" stroke="black" d="M1057.79,-1094.44C1068.46,-1080.83 1107.27,-1032.56 1146.2,-1000.1 1174.63,-976.39 1211.28,-954.25 1235.17,-940.78"/>
+<polygon fill="black" stroke="black" points="1236.92,-943.81 1243.96,-935.89 1233.52,-937.69 1236.92,-943.81"/>
+</g>
+<!-- e_53_center&#45;&gt;glu__L_c -->
+<g id="edge184" class="edge">
+<title>e_53_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" d="M1025.83,-977.02C1035.89,-984.95 1064.66,-1008.22 1085.57,-1030.63 1103.67,-1050.03 1121.96,-1074.13 1134.57,-1091.62"/>
+<polygon fill="black" stroke="black" points="1131.96,-1093.99 1140.61,-1100.11 1137.66,-1089.93 1131.96,-1093.99"/>
+</g>
+<!-- e_53_center&#45;&gt;nh4_c -->
+<g id="edge183" class="edge">
+<title>e_53_center&#45;&gt;nh4_c</title>
+<path fill="none" stroke="black" d="M1025.88,-972.39C1039.57,-965.9 1088.92,-943.38 1132.34,-934.55 1165.81,-927.74 1205.17,-926.54 1231.22,-926.66"/>
+<polygon fill="black" stroke="black" points="1231.47,-930.16 1241.51,-926.78 1231.55,-923.16 1231.47,-930.16"/>
+</g>
+<!-- e_54_center&#45;&gt;glu__L_c -->
+<g id="edge190" class="edge">
+<title>e_54_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" d="M1093.66,-1113.59C1099.42,-1113.75 1111.19,-1114.06 1122.57,-1114.36"/>
+<polygon fill="black" stroke="black" points="1122.63,-1117.87 1132.72,-1114.63 1122.82,-1110.87 1122.63,-1117.87"/>
+</g>
+<!-- e_54_center&#45;&gt;nadp_c -->
+<g id="edge189" class="edge">
+<title>e_54_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="black" d="M1093.96,-1111.62C1105.95,-1105.88 1142.76,-1088.28 1168.1,-1076.16"/>
+<polygon fill="black" stroke="black" points="1169.67,-1079.29 1177.18,-1071.82 1166.65,-1072.98 1169.67,-1079.29"/>
+</g>
+<!-- e_55_center&#45;&gt;h_c -->
+<g id="edge193" class="edge">
+<title>e_55_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1209.02,-1404.47C1187.29,-1394.02 1075.36,-1341.38 977.98,-1317.79 965.6,-1314.79 951.63,-1312.96 939.7,-1311.83"/>
+<polygon fill="black" stroke="black" points="939.67,-1308.32 929.42,-1310.99 939.1,-1315.3 939.67,-1308.32"/>
+</g>
+<!-- e_55_center&#45;&gt;glu__L_c -->
+<g id="edge194" class="edge">
+<title>e_55_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" d="M1212.7,-1402.65C1212.14,-1381.69 1208.27,-1274.19 1186.45,-1189.95 1184.78,-1183.49 1183.53,-1182.13 1180.81,-1176.05 1175.49,-1164.15 1169.19,-1151.17 1163.75,-1140.25"/>
+<polygon fill="black" stroke="black" points="1166.85,-1138.63 1159.24,-1131.27 1160.6,-1141.77 1166.85,-1138.63"/>
+</g>
+<!-- 6pgc_c -->
+<g id="node121" class="node">
+<title>6pgc_c</title>
+<ellipse fill="none" stroke="black" cx="1357.1" cy="-922.35" rx="18" ry="18"/>
+<text text-anchor="middle" x="1357.1" y="-918.65" font-family="Times,serif" font-size="14.00">6pgc_c</text>
+</g>
+<!-- 6pgc_c&#45;&gt;e_56_center -->
+<g id="edge196" class="edge">
+<title>6pgc_c&#45;&gt;e_56_center</title>
+<path fill="none" stroke="black" d="M1348.22,-906.39C1335.34,-883.24 1312.24,-841.72 1305.33,-829.31"/>
+</g>
+<!-- xu5p__D_c -->
+<g id="node147" class="node">
+<title>xu5p__D_c</title>
+<ellipse fill="none" stroke="black" cx="1309.8" cy="-319.98" rx="18" ry="18"/>
+<text text-anchor="middle" x="1309.8" y="-316.28" font-family="Times,serif" font-size="14.00">xu5p__D_c</text>
+</g>
+<!-- ru5p__D_c&#45;&gt;xu5p__D_c -->
+<g id="edge311" class="edge">
+<title>ru5p__D_c&#45;&gt;xu5p__D_c</title>
+<path fill="none" stroke="black" d="M1358.64,-524.38C1349.4,-485.68 1327.42,-393.7 1316.38,-347.48"/>
+<polygon fill="black" stroke="black" points="1319.73,-346.47 1314,-337.56 1312.92,-348.1 1319.73,-346.47"/>
+</g>
+<!-- e_56_center&#45;&gt;co2_c -->
+<g id="edge198" class="edge">
+<title>e_56_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" d="M1299.76,-828.4C1281.3,-842.25 1196.02,-906.26 1154.73,-937.25"/>
+<polygon fill="black" stroke="black" points="1152.53,-934.53 1146.63,-943.33 1156.73,-940.13 1152.53,-934.53"/>
+</g>
+<!-- e_56_center&#45;&gt;nadph_c -->
+<g id="edge199" class="edge">
+<title>e_56_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" d="M1300.6,-829.31C1285.47,-849.19 1211.46,-946.41 1177.31,-991.27"/>
+<polygon fill="black" stroke="black" points="1174.31,-989.43 1171.04,-999.5 1179.88,-993.67 1174.31,-989.43"/>
+</g>
+<!-- e_56_center&#45;&gt;ru5p__D_c -->
+<g id="edge197" class="edge">
+<title>e_56_center&#45;&gt;ru5p__D_c</title>
+<path fill="none" stroke="black" d="M1304.09,-822.13C1309.55,-796.14 1343.24,-635.78 1357.03,-570.14"/>
+<polygon fill="black" stroke="black" points="1360.5,-570.61 1359.14,-560.1 1353.65,-569.17 1360.5,-570.61"/>
+</g>
+<!-- e_58_center&#45;&gt;akg_c -->
+<g id="edge205" class="edge">
+<title>e_58_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="black" d="M1002.21,-1165.5C1015.25,-1163.07 1059.76,-1155.75 1095.81,-1161.76 1111.55,-1164.38 1128.19,-1170.73 1141.4,-1176.73"/>
+<polygon fill="black" stroke="black" points="1140.24,-1180.05 1150.77,-1181.18 1143.24,-1173.73 1140.24,-1180.05"/>
+</g>
+<!-- e_58_center&#45;&gt;co2_c -->
+<g id="edge203" class="edge">
+<title>e_58_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" d="M1000.85,-1162.43C1007.84,-1151.3 1029.01,-1117.96 1048.23,-1091.44 1063.97,-1069.72 1071.03,-1066.56 1085.57,-1044.03 1098.98,-1023.24 1111.74,-998.15 1120.51,-979.77"/>
+<polygon fill="black" stroke="black" points="1123.75,-981.11 1124.84,-970.57 1117.42,-978.13 1123.75,-981.11"/>
+</g>
+<!-- e_58_center&#45;&gt;nadph_c -->
+<g id="edge204" class="edge">
+<title>e_58_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" d="M1002.14,-1162.77C1020.21,-1145.75 1100.21,-1070.36 1138.9,-1033.91"/>
+<polygon fill="black" stroke="black" points="1141.61,-1036.16 1146.49,-1026.75 1136.81,-1031.06 1141.61,-1036.16"/>
+</g>
+<!-- glx_c -->
+<g id="node125" class="node">
+<title>glx_c</title>
+<ellipse fill="none" stroke="black" cx="518.83" cy="-1516.48" rx="18" ry="18"/>
+<text text-anchor="middle" x="518.83" y="-1512.78" font-family="Times,serif" font-size="14.00">glx_c</text>
+</g>
+<!-- glx_c&#45;&gt;e_61_center -->
+<g id="edge216" class="edge">
+<title>glx_c&#45;&gt;e_61_center</title>
+<path fill="none" stroke="black" d="M533.35,-1505.72C579.82,-1471.32 723.22,-1365.14 747.52,-1347.15"/>
+</g>
+<!-- e_59_center&#45;&gt;succ_c -->
+<g id="edge208" class="edge">
+<title>e_59_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" d="M543.26,-1615.01C561.86,-1619.5 645.75,-1639.73 689.9,-1650.39"/>
+<polygon fill="black" stroke="black" points="689.16,-1653.81 699.7,-1652.75 690.8,-1647 689.16,-1653.81"/>
+</g>
+<!-- e_59_center&#45;&gt;glx_c -->
+<g id="edge207" class="edge">
+<title>e_59_center&#45;&gt;glx_c</title>
+<path fill="none" stroke="black" d="M538.76,-1610.41C536.48,-1599.67 529.72,-1567.79 524.7,-1544.14"/>
+<polygon fill="black" stroke="black" points="528.1,-1543.33 522.6,-1534.27 521.26,-1544.78 528.1,-1543.33"/>
+</g>
+<!-- e_60_center&#45;&gt;nadh_c -->
+<g id="edge211" class="edge">
+<title>e_60_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" d="M999.09,-1253.88C1004.74,-1247.65 1016.64,-1234.54 1027.09,-1223.02"/>
+<polygon fill="black" stroke="black" points="1029.88,-1225.16 1034.01,-1215.4 1024.7,-1220.45 1029.88,-1225.16"/>
+</g>
+<!-- e_60_center&#45;&gt;h_c -->
+<g id="edge213" class="edge">
+<title>e_60_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M992.14,-1259.81C982.51,-1265.81 955.67,-1282.53 935.56,-1295.07"/>
+<polygon fill="black" stroke="black" points="933.52,-1292.21 926.88,-1300.47 937.22,-1298.16 933.52,-1292.21"/>
+</g>
+<!-- e_60_center&#45;&gt;pyr_c -->
+<g id="edge212" class="edge">
+<title>e_60_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" d="M993.21,-1254.02C974.23,-1227.79 854.7,-1062.55 810.34,-1001.23"/>
+<polygon fill="black" stroke="black" points="813.06,-999.02 804.36,-992.97 807.39,-1003.12 813.06,-999.02"/>
+</g>
+<!-- e_61_center&#45;&gt;coa_c -->
+<g id="edge218" class="edge">
+<title>e_61_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" d="M753.79,-1340.92C765.4,-1325.65 811,-1265.7 836.47,-1232.22"/>
+<polygon fill="black" stroke="black" points="839.51,-1234 842.78,-1223.92 833.94,-1229.76 839.51,-1234"/>
+</g>
+<!-- e_61_center&#45;&gt;h_c -->
+<g id="edge219" class="edge">
+<title>e_61_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M754.69,-1343.76C771.64,-1340.12 843.52,-1324.69 883.79,-1316.04"/>
+<polygon fill="black" stroke="black" points="884.73,-1319.42 893.77,-1313.9 883.26,-1312.58 884.73,-1319.42"/>
+</g>
+<!-- e_61_center&#45;&gt;mal__L_c -->
+<g id="edge217" class="edge">
+<title>e_61_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" d="M754.6,-1344.43C776.59,-1343.74 894.66,-1340.02 949.68,-1338.28"/>
+<polygon fill="black" stroke="black" points="949.91,-1341.78 959.8,-1337.96 949.69,-1334.78 949.91,-1341.78"/>
+</g>
+<!-- e_62_center&#45;&gt;h_c -->
+<g id="edge223" class="edge">
+<title>e_62_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1116.48,-1554.31C1096.14,-1530.09 975.83,-1386.82 929.55,-1331.71"/>
+<polygon fill="black" stroke="black" points="932.14,-1329.35 923.03,-1323.94 926.78,-1333.85 932.14,-1329.35"/>
+</g>
+<!-- e_62_center&#45;&gt;mal__L_c -->
+<g id="edge222" class="edge">
+<title>e_62_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" d="M1116.97,-1553.98C1102.32,-1531.17 1026.05,-1412.35 993.11,-1361.04"/>
+<polygon fill="black" stroke="black" points="996.02,-1359.08 987.67,-1352.56 990.13,-1362.86 996.02,-1359.08"/>
+</g>
+<!-- e_63_center&#45;&gt;nadh_c -->
+<g id="edge226" class="edge">
+<title>e_63_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" d="M951.33,-1221.15C962.21,-1218.92 994.49,-1212.32 1018.45,-1207.41"/>
+<polygon fill="black" stroke="black" points="1019.35,-1210.8 1028.44,-1205.37 1017.94,-1203.94 1019.35,-1210.8"/>
+</g>
+<!-- e_63_center&#45;&gt;h_c -->
+<g id="edge227" class="edge">
+<title>e_63_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M946.02,-1225.71C941.96,-1235.62 930.75,-1262.96 922.18,-1283.86"/>
+<polygon fill="black" stroke="black" points="918.9,-1282.63 918.34,-1293.21 925.38,-1285.29 918.9,-1282.63"/>
+</g>
+<!-- e_63_center&#45;&gt;oaa_c -->
+<g id="edge228" class="edge">
+<title>e_63_center&#45;&gt;oaa_c</title>
+<path fill="none" stroke="black" d="M944.9,-1218.3C931.95,-1200.78 875.3,-1124.17 846.61,-1085.38"/>
+<polygon fill="black" stroke="black" points="849.38,-1083.23 840.62,-1077.27 843.75,-1087.39 849.38,-1083.23"/>
+</g>
+<!-- e_64_center&#45;&gt;nadh_c -->
+<g id="edge232" class="edge">
+<title>e_64_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" d="M998.81,-1109.69C1004.4,-1120.48 1021.28,-1153.07 1033.36,-1176.39"/>
+<polygon fill="black" stroke="black" points="1030.33,-1178.15 1038.04,-1185.42 1036.54,-1174.93 1030.33,-1178.15"/>
+</g>
+<!-- e_64_center&#45;&gt;co2_c -->
+<g id="edge231" class="edge">
+<title>e_64_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" d="M998.94,-1102.37C1003.78,-1093.65 1016.67,-1071.23 1030.26,-1054.55 1055.45,-1023.64 1089.13,-992.03 1110.75,-972.74"/>
+<polygon fill="black" stroke="black" points="1113.23,-975.22 1118.4,-965.98 1108.59,-969.97 1113.23,-975.22"/>
+</g>
+<!-- e_64_center&#45;&gt;pyr_c -->
+<g id="edge233" class="edge">
+<title>e_64_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" d="M993.1,-1105.05C985.21,-1102.9 966.69,-1097.46 952.36,-1090.12 899.99,-1063.27 845.23,-1021.01 815.75,-996.88"/>
+<polygon fill="black" stroke="black" points="817.73,-993.97 807.79,-990.3 813.27,-999.37 817.73,-993.97"/>
+</g>
+<!-- e_65_center&#45;&gt;co2_c -->
+<g id="edge236" class="edge">
+<title>e_65_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" d="M1040.13,-1057.69C1051.36,-1045.06 1089.87,-1001.76 1113.38,-975.32"/>
+<polygon fill="black" stroke="black" points="1116.12,-977.51 1120.15,-967.71 1110.89,-972.86 1116.12,-977.51"/>
+</g>
+<!-- e_65_center&#45;&gt;nadph_c -->
+<g id="edge238" class="edge">
+<title>e_65_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" d="M1040.52,-1060.05C1048.57,-1057.31 1068.82,-1050.37 1085.57,-1044.03 1101.61,-1037.96 1119.43,-1030.79 1133.61,-1024.98"/>
+<polygon fill="black" stroke="black" points="1135.3,-1028.07 1143.22,-1021.03 1132.64,-1021.6 1135.3,-1028.07"/>
+</g>
+<!-- e_65_center&#45;&gt;pyr_c -->
+<g id="edge237" class="edge">
+<title>e_65_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" d="M1033.41,-1059.79C1023.02,-1055.54 991.73,-1042.87 965.34,-1033.52 914.83,-1015.64 855.12,-997 821.13,-986.62"/>
+<polygon fill="black" stroke="black" points="822.04,-983.23 811.45,-983.67 820,-989.93 822.04,-983.23"/>
+</g>
+<!-- e_66_center&#45;&gt;nad_c -->
+<g id="edge244" class="edge">
+<title>e_66_center&#45;&gt;nad_c</title>
+<path fill="none" stroke="black" d="M967.24,-1471.83C977.18,-1448.53 1032.41,-1319.38 1079.78,-1215.14 1080.98,-1212.48 1082.26,-1209.71 1083.54,-1206.96"/>
+<polygon fill="black" stroke="black" points="1086.75,-1208.35 1087.82,-1197.81 1080.41,-1205.38 1086.75,-1208.35"/>
+</g>
+<!-- e_66_center&#45;&gt;h_e -->
+<g id="edge243" class="edge">
+<title>e_66_center&#45;&gt;h_e</title>
+<path fill="none" stroke="black" d="M961.93,-1478.64C957.13,-1482.64 948.44,-1489.9 940.05,-1496.91"/>
+<polygon fill="black" stroke="black" points="937.66,-1494.34 932.23,-1503.43 942.15,-1499.71 937.66,-1494.34"/>
+</g>
+<!-- e_66_center&#45;&gt;q8h2_c -->
+<g id="edge242" class="edge">
+<title>e_66_center&#45;&gt;q8h2_c</title>
+<path fill="none" stroke="black" d="M963.42,-1479.2C958.05,-1487.96 944.03,-1510.68 931.74,-1529.28 889.57,-1593.1 837.7,-1666.9 811.69,-1703.61"/>
+<polygon fill="black" stroke="black" points="808.59,-1701.93 805.66,-1712.11 814.3,-1705.98 808.59,-1701.93"/>
+</g>
+<!-- e_67_center&#45;&gt;nadh_c -->
+<g id="edge248" class="edge">
+<title>e_67_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" d="M1274.88,-1136.09C1259.78,-1139.98 1199.83,-1155.96 1153.09,-1175.86 1127.42,-1186.79 1122.89,-1195.4 1095.54,-1200.96 1088.96,-1202.29 1081.79,-1202.87 1075.01,-1203.04"/>
+<polygon fill="black" stroke="black" points="1074.82,-1199.54 1064.81,-1203.01 1074.8,-1206.54 1074.82,-1199.54"/>
+</g>
+<!-- e_67_center&#45;&gt;nadp_c -->
+<g id="edge247" class="edge">
+<title>e_67_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="black" d="M1274.81,-1132.12C1264.71,-1123.65 1235.79,-1099.4 1215.34,-1082.25"/>
+<polygon fill="black" stroke="black" points="1217.35,-1079.37 1207.44,-1075.63 1212.85,-1084.73 1217.35,-1079.37"/>
+</g>
+<!-- e_70_center&#45;&gt;accoa_c -->
+<g id="edge254" class="edge">
+<title>e_70_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="black" d="M955.39,-1085.31C939.13,-1093.67 872.85,-1127.77 835.78,-1146.84"/>
+<polygon fill="black" stroke="black" points="833.89,-1143.88 826.6,-1151.56 837.09,-1150.1 833.89,-1143.88"/>
+</g>
+<!-- e_70_center&#45;&gt;nadh_c -->
+<g id="edge256" class="edge">
+<title>e_70_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" d="M961.77,-1087.09C971.89,-1100.78 1008,-1149.64 1029.66,-1178.95"/>
+<polygon fill="black" stroke="black" points="1026.86,-1181.05 1035.62,-1187.01 1032.49,-1176.89 1026.86,-1181.05"/>
+</g>
+<!-- e_70_center&#45;&gt;co2_c -->
+<g id="edge255" class="edge">
+<title>e_70_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" d="M962.68,-1080.72C981.36,-1066.77 1067.65,-1002.35 1109.43,-971.16"/>
+<polygon fill="black" stroke="black" points="1111.71,-973.82 1117.63,-965.04 1107.52,-968.21 1111.71,-973.82"/>
+</g>
+<!-- e_71_center&#45;&gt;h_c -->
+<g id="edge260" class="edge">
+<title>e_71_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M839.5,-904.98C845.39,-938.16 891.12,-1195.77 906.43,-1282.06"/>
+<polygon fill="black" stroke="black" points="903.03,-1282.92 908.23,-1292.16 909.92,-1281.7 903.03,-1282.92"/>
+</g>
+<!-- e_71_center&#45;&gt;adp_c -->
+<g id="edge261" class="edge">
+<title>e_71_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" d="M835.36,-904.46C821.39,-916.45 769.05,-961.37 738.89,-987.25"/>
+<polygon fill="black" stroke="black" points="736.34,-984.83 731.03,-994 740.89,-990.14 736.34,-984.83"/>
+</g>
+<!-- e_71_center&#45;&gt;fdp_c -->
+<g id="edge259" class="edge">
+<title>e_71_center&#45;&gt;fdp_c</title>
+<path fill="none" stroke="black" d="M839.44,-897.71C842.26,-878.67 854.56,-790.52 852.23,-718.11 851.33,-690.12 846.55,-658.46 842.61,-636.43"/>
+<polygon fill="black" stroke="black" points="846.02,-635.64 840.76,-626.45 839.14,-636.92 846.02,-635.64"/>
+</g>
+<!-- e_72_center&#45;&gt;accoa_c -->
+<g id="edge264" class="edge">
+<title>e_72_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="black" d="M619.06,-1222.94C639.18,-1216.31 735.75,-1184.49 783.51,-1168.76"/>
+<polygon fill="black" stroke="black" points="784.78,-1172.03 793.18,-1165.57 782.59,-1165.38 784.78,-1172.03"/>
+</g>
+<!-- e_72_center&#45;&gt;for_c -->
+<g id="edge265" class="edge">
+<title>e_72_center&#45;&gt;for_c</title>
+<path fill="none" stroke="black" d="M612.38,-1227.92C593.27,-1252.19 486.75,-1387.41 444.33,-1441.26"/>
+<polygon fill="black" stroke="black" points="441.53,-1439.16 438.09,-1449.18 447.03,-1443.49 441.53,-1439.16"/>
+</g>
+<!-- e_74_center&#45;&gt;adp_c -->
+<g id="edge270" class="edge">
+<title>e_74_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" d="M665.82,-811.12C671.22,-831.61 697.1,-929.96 709.9,-978.6"/>
+<polygon fill="black" stroke="black" points="706.57,-979.67 712.5,-988.45 713.34,-977.89 706.57,-979.67"/>
+</g>
+<!-- e_74_center&#45;&gt;13dpg_c -->
+<g id="edge269" class="edge">
+<title>e_74_center&#45;&gt;13dpg_c</title>
+<path fill="none" stroke="black" d="M668.33,-805.47C686.01,-796.05 766.23,-753.34 807.67,-731.28"/>
+<polygon fill="black" stroke="black" points="809.42,-734.31 816.6,-726.52 806.13,-728.13 809.42,-734.31"/>
+</g>
+<!-- e_75_center&#45;&gt;h_c -->
+<g id="edge273" class="edge">
+<title>e_75_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1076.75,-1040.98C1071.72,-1049.68 1058.7,-1072.31 1048.23,-1091.44 1028.57,-1127.38 1026.33,-1137.86 1005.17,-1172.94 980.27,-1214.21 947.93,-1260.05 928.47,-1286.91"/>
+<polygon fill="black" stroke="black" points="925.45,-1285.11 922.39,-1295.26 931.11,-1289.23 925.45,-1285.11"/>
+</g>
+<!-- e_75_center&#45;&gt;6pgc_c -->
+<g id="edge274" class="edge">
+<title>e_75_center&#45;&gt;6pgc_c</title>
+<path fill="none" stroke="black" d="M1082.44,-1035.15C1092.35,-1029.17 1121.14,-1012.08 1146.2,-1000.1 1210,-969.58 1289.16,-943.31 1329.96,-930.57"/>
+<polygon fill="black" stroke="black" points="1331.19,-933.85 1339.71,-927.55 1329.12,-927.16 1331.19,-933.85"/>
+</g>
+<!-- e_77_center&#45;&gt;h_c -->
+<g id="edge279" class="edge">
+<title>e_77_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M684.66,-1441.52C707.55,-1428.25 833.07,-1355.52 886.89,-1324.33"/>
+<polygon fill="black" stroke="black" points="888.87,-1327.22 895.77,-1319.18 885.36,-1321.17 888.87,-1327.22"/>
+</g>
+<!-- e_77_center&#45;&gt;pi_c -->
+<g id="edge278" class="edge">
+<title>e_77_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" d="M682.09,-1439.81C690.45,-1409.51 746.4,-1206.71 766.98,-1132.12"/>
+<polygon fill="black" stroke="black" points="770.46,-1132.65 769.75,-1122.08 763.71,-1130.79 770.46,-1132.65"/>
+</g>
+<!-- e_78_center&#45;&gt;h_c -->
+<g id="edge284" class="edge">
+<title>e_78_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M882.26,-1033.72C884.96,-1059.32 901.59,-1216.97 908.45,-1282.06"/>
+<polygon fill="black" stroke="black" points="904.98,-1282.45 909.51,-1292.03 911.94,-1281.71 904.98,-1282.45"/>
+</g>
+<!-- e_78_center&#45;&gt;pi_c -->
+<g id="edge283" class="edge">
+<title>e_78_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" d="M879.77,-1033.84C874.62,-1042.44 860.62,-1064.14 843.61,-1076.65 831.15,-1085.81 815.27,-1092.52 801.88,-1097.07"/>
+<polygon fill="black" stroke="black" points="800.69,-1093.78 792.22,-1100.14 802.81,-1100.45 800.69,-1093.78"/>
+</g>
+<!-- e_78_center&#45;&gt;oaa_c -->
+<g id="edge285" class="edge">
+<title>e_78_center&#45;&gt;oaa_c</title>
+<path fill="none" stroke="black" d="M878.15,-1032.52C872.99,-1035.74 863.27,-1041.82 853.89,-1047.67"/>
+<polygon fill="black" stroke="black" points="851.79,-1044.86 845.16,-1053.13 855.5,-1050.8 851.79,-1044.86"/>
+</g>
+<!-- e_79_center&#45;&gt;adp_c -->
+<g id="edge290" class="edge">
+<title>e_79_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" d="M868.93,-895.04C852,-907.41 778.44,-961.14 740.28,-989.02"/>
+<polygon fill="black" stroke="black" points="737.84,-986.47 731.83,-995.19 741.97,-992.12 737.84,-986.47"/>
+</g>
+<!-- e_79_center&#45;&gt;co2_c -->
+<g id="edge288" class="edge">
+<title>e_79_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" d="M876.14,-893.32C900.8,-899.18 1043.22,-933.01 1104.35,-947.53"/>
+<polygon fill="black" stroke="black" points="1103.9,-951.02 1114.44,-949.93 1105.52,-944.21 1103.9,-951.02"/>
+</g>
+<!-- e_79_center&#45;&gt;pep_c -->
+<g id="edge289" class="edge">
+<title>e_79_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="black" d="M868.79,-890.62C854.58,-883.56 802.49,-857.65 770.58,-841.78"/>
+<polygon fill="black" stroke="black" points="771.9,-838.53 761.39,-837.21 768.79,-844.8 771.9,-838.53"/>
+</g>
+<!-- e_80_center&#45;&gt;h_c -->
+<g id="edge296" class="edge">
+<title>e_80_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M667.63,-1026.51C691.04,-1053.74 839.59,-1226.56 892.63,-1288.26"/>
+<polygon fill="black" stroke="black" points="890.28,-1290.9 899.45,-1296.2 895.59,-1286.34 890.28,-1290.9"/>
+</g>
+<!-- e_80_center&#45;&gt;amp_c -->
+<g id="edge294" class="edge">
+<title>e_80_center&#45;&gt;amp_c</title>
+<path fill="none" stroke="black" d="M660.77,-1020.33C636.84,-1003.98 504.47,-913.55 449.93,-876.28"/>
+<polygon fill="black" stroke="black" points="451.81,-873.33 441.58,-870.58 447.86,-879.11 451.81,-873.33"/>
+</g>
+<!-- e_80_center&#45;&gt;pi_c -->
+<g id="edge297" class="edge">
+<title>e_80_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" d="M667.94,-1026.53C675.06,-1034 692.15,-1051.38 708.37,-1063.76 721.5,-1073.78 737.19,-1083.56 750,-1091.04"/>
+<polygon fill="black" stroke="black" points="748.32,-1094.12 758.74,-1096.06 751.81,-1088.05 748.32,-1094.12"/>
+</g>
+<!-- e_80_center&#45;&gt;pep_c -->
+<g id="edge295" class="edge">
+<title>e_80_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="black" d="M666.05,-1019.18C674.39,-999.1 714.56,-902.33 734.17,-855.1"/>
+<polygon fill="black" stroke="black" points="737.42,-856.39 738.02,-845.82 730.96,-853.71 737.42,-856.39"/>
+</g>
+<!-- e_81_center&#45;&gt;coa_c -->
+<g id="edge300" class="edge">
+<title>e_81_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" d="M595.5,-1131.02C620.5,-1138.59 765.38,-1182.46 826.61,-1201.01"/>
+<polygon fill="black" stroke="black" points="825.77,-1204.41 836.36,-1203.96 827.8,-1197.71 825.77,-1204.41"/>
+</g>
+<!-- e_81_center&#45;&gt;actp_c -->
+<g id="edge301" class="edge">
+<title>e_81_center&#45;&gt;actp_c</title>
+<path fill="none" stroke="black" d="M588.04,-1129.24C562.69,-1124.82 415.76,-1099.2 353.66,-1088.37"/>
+<polygon fill="black" stroke="black" points="354.23,-1084.92 343.77,-1086.65 353.02,-1091.81 354.23,-1084.92"/>
+</g>
+<!-- e_82_center&#45;&gt;atp_c -->
+<g id="edge305" class="edge">
+<title>e_82_center&#45;&gt;atp_c</title>
+<path fill="none" stroke="black" d="M773.8,-1042.84C768.87,-1043.53 759.6,-1044.81 750.27,-1046.11"/>
+<polygon fill="black" stroke="black" points="749.74,-1042.65 740.32,-1047.49 750.7,-1049.58 749.74,-1042.65"/>
+</g>
+<!-- e_82_center&#45;&gt;pyr_c -->
+<g id="edge306" class="edge">
+<title>e_82_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" d="M778.39,-1038.53C780.04,-1032.08 783.53,-1018.47 786.77,-1005.82"/>
+<polygon fill="black" stroke="black" points="790.18,-1006.6 789.28,-996.04 783.4,-1004.86 790.18,-1006.6"/>
+</g>
+<!-- e_83_center&#45;&gt;h_c -->
+<g id="edge310" class="edge">
+<title>e_83_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M647.93,-1319.93C673.31,-1318.98 819.84,-1313.53 882.74,-1311.18"/>
+<polygon fill="black" stroke="black" points="883.26,-1314.67 893.12,-1310.8 883,-1307.67 883.26,-1314.67"/>
+</g>
+<!-- e_83_center&#45;&gt;pyr_c -->
+<g id="edge309" class="edge">
+<title>e_83_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" d="M645.05,-1316.35C650.03,-1295.8 675.64,-1194.37 713.12,-1118.36 733.74,-1076.54 761.6,-1030.01 778.6,-1002.52"/>
+<polygon fill="black" stroke="black" points="781.61,-1004.3 783.92,-993.96 775.67,-1000.6 781.61,-1004.3"/>
+</g>
+<!-- xu5p__D_c&#45;&gt;e_92_center -->
+<g id="edge342" class="edge">
+<title>xu5p__D_c&#45;&gt;e_92_center</title>
+<path fill="none" stroke="black" d="M1293.37,-327.64C1264.17,-341.26 1204.89,-368.92 1189.66,-376.02"/>
+</g>
+<!-- xu5p__D_c&#45;&gt;e_93_center -->
+<g id="edge346" class="edge">
+<title>xu5p__D_c&#45;&gt;e_93_center</title>
+<path fill="none" stroke="black" d="M1294.8,-330.05C1254.9,-356.85 1147.74,-428.83 1126.38,-443.17"/>
+</g>
+<!-- e_86_center&#45;&gt;h_c -->
+<g id="edge316" class="edge">
+<title>e_86_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M866.7,-1642.03C870.72,-1612.17 897.55,-1413.02 907.61,-1338.33"/>
+<polygon fill="black" stroke="black" points="911.1,-1338.63 908.97,-1328.25 904.17,-1337.7 911.1,-1338.63"/>
+</g>
+<!-- e_86_center&#45;&gt;succ_c -->
+<g id="edge315" class="edge">
+<title>e_86_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" d="M862.51,-1646.08C846.65,-1647.27 783.28,-1652.03 745.68,-1654.85"/>
+<polygon fill="black" stroke="black" points="745.08,-1651.39 735.38,-1655.63 745.61,-1658.37 745.08,-1651.39"/>
+</g>
+<!-- e_87_center&#45;&gt;h_c -->
+<g id="edge320" class="edge">
+<title>e_87_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M897,-1647C896.86,-1631.02 896.47,-1567.41 898.38,-1515.18 900.7,-1451.96 906.06,-1377.93 909.14,-1338.4"/>
+<polygon fill="black" stroke="black" points="912.64,-1338.45 909.94,-1328.2 905.66,-1337.9 912.64,-1338.45"/>
+</g>
+<!-- e_87_center&#45;&gt;succ_e -->
+<g id="edge319" class="edge">
+<title>e_87_center&#45;&gt;succ_e</title>
+<path fill="none" stroke="black" d="M896.83,-1654.37C895.34,-1680.37 886.13,-1840.44 882.34,-1906.53"/>
+<polygon fill="black" stroke="black" points="878.83,-1906.46 881.75,-1916.65 885.82,-1906.87 878.83,-1906.46"/>
+</g>
+<!-- e_88_center&#45;&gt;q8h2_c -->
+<g id="edge323" class="edge">
+<title>e_88_center&#45;&gt;q8h2_c</title>
+<path fill="none" stroke="black" d="M760.39,-1875.51C764.23,-1859.09 779.73,-1792.83 788.69,-1754.54"/>
+<polygon fill="black" stroke="black" points="792.15,-1755.08 791.02,-1744.55 785.34,-1753.49 792.15,-1755.08"/>
+</g>
+<!-- e_88_center&#45;&gt;fum_c -->
+<g id="edge324" class="edge">
+<title>e_88_center&#45;&gt;fum_c</title>
+<path fill="none" stroke="black" d="M762.05,-1875.45C769.92,-1863.59 794.33,-1826.79 810.74,-1802.07"/>
+<polygon fill="black" stroke="black" points="813.76,-1803.84 816.37,-1793.58 807.93,-1799.97 813.76,-1803.84"/>
+</g>
+<!-- e_89_center&#45;&gt;adp_c -->
+<g id="edge330" class="edge">
+<title>e_89_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" d="M743.14,-1296.95C738.09,-1275.89 712.03,-1166.42 707.37,-1132.21 702.42,-1095.89 697.96,-1086.21 702.72,-1049.86 703.47,-1044.09 704.95,-1038.07 706.69,-1032.4"/>
+<polygon fill="black" stroke="black" points="710.08,-1033.3 709.98,-1022.7 703.45,-1031.04 710.08,-1033.3"/>
+</g>
+<!-- e_89_center&#45;&gt;succoa_c -->
+<g id="edge329" class="edge">
+<title>e_89_center&#45;&gt;succoa_c</title>
+<path fill="none" stroke="black" d="M747.49,-1302.06C767.81,-1311.3 871.11,-1358.27 920.22,-1380.6"/>
+<polygon fill="black" stroke="black" points="919,-1383.89 929.55,-1384.85 921.9,-1377.52 919,-1383.89"/>
+</g>
+<!-- e_89_center&#45;&gt;pi_c -->
+<g id="edge328" class="edge">
+<title>e_89_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" d="M744.57,-1296.73C747.7,-1276.68 762.65,-1180.92 770.18,-1132.63"/>
+<polygon fill="black" stroke="black" points="773.68,-1132.96 771.76,-1122.54 766.76,-1131.88 773.68,-1132.96"/>
+</g>
+<!-- s7p_c -->
+<g id="node152" class="node">
+<title>s7p_c</title>
+<ellipse fill="none" stroke="black" cx="1172.99" cy="-195.1" rx="18" ry="18"/>
+<text text-anchor="middle" x="1172.99" y="-191.4" font-family="Times,serif" font-size="14.00">s7p_c</text>
+</g>
+<!-- s7p_c&#45;&gt;e_90_center -->
+<g id="edge331" class="edge">
+<title>s7p_c&#45;&gt;e_90_center</title>
+<path fill="none" stroke="black" d="M1164.48,-211.18C1140.95,-255.61 1076.03,-378.24 1064.06,-400.84"/>
+</g>
+<!-- e_90_center&#45;&gt;e4p_c -->
+<g id="edge334" class="edge">
+<title>e_90_center&#45;&gt;e4p_c</title>
+<path fill="none" stroke="black" d="M1062.3,-408.04C1063.17,-428.66 1067.53,-532.7 1069.66,-583.55"/>
+<polygon fill="black" stroke="black" points="1066.17,-583.7 1070.08,-593.55 1073.16,-583.41 1066.17,-583.7"/>
+</g>
+<!-- e_90_center&#45;&gt;f6p_c -->
+<g id="edge333" class="edge">
+<title>e_90_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" d="M1060.15,-408.29C1047.45,-432.71 977.57,-567.08 948.07,-623.82"/>
+<polygon fill="black" stroke="black" points="944.88,-622.36 943.37,-632.85 951.09,-625.59 944.88,-622.36"/>
+</g>
+<!-- e_91_center&#45;&gt;nad_c -->
+<g id="edge340" class="edge">
+<title>e_91_center&#45;&gt;nad_c</title>
+<path fill="none" stroke="black" d="M1115.38,-1268.54C1113.09,-1258.41 1106.82,-1230.64 1101.96,-1209.14"/>
+<polygon fill="black" stroke="black" points="1105.33,-1208.17 1099.71,-1199.19 1098.5,-1209.72 1105.33,-1208.17"/>
+</g>
+<!-- e_91_center&#45;&gt;h_c -->
+<g id="edge339" class="edge">
+<title>e_91_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1112.71,-1273.1C1092.33,-1276.85 989.44,-1295.77 939.16,-1305.01"/>
+<polygon fill="black" stroke="black" points="938.48,-1301.58 929.27,-1306.83 939.74,-1308.46 938.48,-1301.58"/>
+</g>
+<!-- e_91_center&#45;&gt;nadph_c -->
+<g id="edge338" class="edge">
+<title>e_91_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" d="M1116.38,-1268.52C1116.96,-1250.67 1119.98,-1175.49 1131.34,-1115.06 1136.13,-1089.58 1144.44,-1061.23 1150.88,-1041.07"/>
+<polygon fill="black" stroke="black" points="1154.28,-1041.92 1154.04,-1031.33 1147.62,-1039.75 1154.28,-1041.92"/>
+</g>
+<!-- e_92_center&#45;&gt;g3p_c -->
+<g id="edge344" class="edge">
+<title>e_92_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="black" d="M1183.26,-381.5C1175.15,-392.54 1150.67,-425.67 1129.35,-452.38 1098.8,-490.64 1061.88,-534.06 1040.11,-559.39"/>
+<polygon fill="black" stroke="black" points="1037.21,-557.39 1033.34,-567.25 1042.52,-561.96 1037.21,-557.39"/>
+</g>
+<!-- e_92_center&#45;&gt;s7p_c -->
+<g id="edge343" class="edge">
+<title>e_92_center&#45;&gt;s7p_c</title>
+<path fill="none" stroke="black" d="M1185.76,-373.9C1184.39,-354.79 1178.24,-268.59 1175,-223.23"/>
+<polygon fill="black" stroke="black" points="1178.48,-222.88 1174.28,-213.16 1171.5,-223.38 1178.48,-222.88"/>
+</g>
+<!-- e_93_center&#45;&gt;g3p_c -->
+<g id="edge348" class="edge">
+<title>e_93_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="black" d="M1119.94,-449.3C1108.52,-464.57 1063.67,-524.52 1038.62,-558.01"/>
+<polygon fill="black" stroke="black" points="1035.61,-556.2 1032.42,-566.31 1041.21,-560.4 1035.61,-556.2"/>
+</g>
+<!-- e_93_center&#45;&gt;f6p_c -->
+<g id="edge347" class="edge">
+<title>e_93_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" d="M1119.03,-449.41C1104.73,-464.16 1050.84,-519.93 1007.72,-566.98 989.02,-587.38 968.11,-611.07 953.51,-627.74"/>
+<polygon fill="black" stroke="black" points="950.83,-625.49 946.89,-635.32 956.11,-630.1 950.83,-625.49"/>
+</g>
+</g>
+</svg>
\ No newline at end of file
diff --git a/jupyter_execute/66ec3dbd2d4149b75be0407118008cbd8c54d4d16f6cc666b9a7938a007211b1.svg b/jupyter_execute/66ec3dbd2d4149b75be0407118008cbd8c54d4d16f6cc666b9a7938a007211b1.svg
new file mode 100644
index 00000000..e15b78e5
--- /dev/null
+++ b/jupyter_execute/66ec3dbd2d4149b75be0407118008cbd8c54d4d16f6cc666b9a7938a007211b1.svg
@@ -0,0 +1,2802 @@
+<?xml version="1.0" encoding="UTF-8" standalone="no"?>
+<!DOCTYPE svg PUBLIC "-//W3C//DTD SVG 1.1//EN"
+ "http://www.w3.org/Graphics/SVG/1.1/DTD/svg11.dtd">
+<!-- Generated by graphviz version 2.43.0 (0)
+ -->
+<!-- Title: %3 Pages: 1 -->
+<svg width="2169pt" height="2236pt"
+ viewBox="0.00 0.00 2169.00 2236.00" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
+<g id="graph0" class="graph" transform="scale(1 1) rotate(0) translate(4 2232)">
+<title>%3</title>
+<polygon fill="white" stroke="transparent" points="-4,4 -4,-2232 2165,-2232 2165,4 -4,4"/>
+<!-- coa_c -->
+<g id="node1" class="node">
+<title>coa_c</title>
+<ellipse fill="none" stroke="black" cx="1015" cy="-1106.52" rx="18" ry="18"/>
+<text text-anchor="middle" x="1015" y="-1102.82" font-family="Times,serif" font-size="14.00">coa_c</text>
+</g>
+<!-- e_0_center -->
+<g id="node7" class="node">
+<title>e_0_center</title>
+<polygon fill="none" stroke="black" points="1228.52,-1209.9 1221.52,-1209.9 1221.52,-1202.9 1228.52,-1202.9 1228.52,-1209.9"/>
+</g>
+<!-- coa_c&#45;&gt;e_0_center -->
+<g id="edge1" class="edge">
+<title>coa_c&#45;&gt;e_0_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1031.48,-1114.35C1076.35,-1135.69 1198.85,-1193.95 1221.42,-1204.68"/>
+</g>
+<!-- e_7_center -->
+<g id="node28" class="node">
+<title>e_7_center</title>
+<polygon fill="none" stroke="black" points="1205.03,-1100.88 1198.03,-1100.88 1198.03,-1093.88 1205.03,-1093.88 1205.03,-1100.88"/>
+</g>
+<!-- coa_c&#45;&gt;e_7_center -->
+<g id="edge25" class="edge">
+<title>coa_c&#45;&gt;e_7_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1033.03,-1108.93C1054.14,-1111.43 1090.17,-1114.74 1121.11,-1112.72 1151.18,-1110.76 1186.6,-1101.52 1197.89,-1098.41"/>
+</g>
+<!-- e_70_center -->
+<g id="node135" class="node">
+<title>e_70_center</title>
+<polygon fill="none" stroke="black" points="1201.34,-1000.02 1194.34,-1000.02 1194.34,-993.02 1201.34,-993.02 1201.34,-1000.02"/>
+</g>
+<!-- coa_c&#45;&gt;e_70_center -->
+<g id="edge251" class="edge">
+<title>coa_c&#45;&gt;e_70_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.7" d="M1032.12,-1100.68C1042.8,-1096.99 1056.79,-1092.05 1069.08,-1087.39 1075.32,-1085.02 1077.17,-1085.01 1082.98,-1081.74 1130.17,-1055.22 1180.28,-1012.06 1194.12,-999.84"/>
+</g>
+<!-- e_72_center -->
+<g id="node137" class="node">
+<title>e_72_center</title>
+<polygon fill="none" stroke="black" points="1284.92,-1123.9 1277.92,-1123.9 1277.92,-1116.9 1284.92,-1116.9 1284.92,-1123.9"/>
+</g>
+<!-- coa_c&#45;&gt;e_72_center -->
+<g id="edge262" class="edge">
+<title>coa_c&#45;&gt;e_72_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1033.02,-1107.63C1054.13,-1108.92 1090.15,-1111.07 1121.11,-1112.72 1183.44,-1116.03 1259.43,-1119.43 1277.46,-1120.23"/>
+</g>
+<!-- e_89_center -->
+<g id="node151" class="node">
+<title>e_89_center</title>
+<polygon fill="none" stroke="black" points="811.94,-1169.54 804.94,-1169.54 804.94,-1162.54 811.94,-1162.54 811.94,-1169.54"/>
+</g>
+<!-- coa_c&#45;&gt;e_89_center -->
+<g id="edge325" class="edge">
+<title>coa_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M997.38,-1111.59C952.31,-1124.58 834.73,-1158.46 812.2,-1164.96"/>
+</g>
+<!-- acald_c -->
+<g id="node2" class="node">
+<title>acald_c</title>
+<ellipse fill="none" stroke="black" cx="1557.48" cy="-1324.36" rx="18" ry="18"/>
+<text text-anchor="middle" x="1557.48" y="-1320.66" font-family="Times,serif" font-size="14.00">acald_c</text>
+</g>
+<!-- acald_c&#45;&gt;e_0_center -->
+<g id="edge2" class="edge">
+<title>acald_c&#45;&gt;e_0_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1540.07,-1318.18C1476.47,-1295.61 1258.82,-1218.39 1228.53,-1207.64"/>
+</g>
+<!-- nad_c -->
+<g id="node3" class="node">
+<title>nad_c</title>
+<ellipse fill="none" stroke="black" cx="1121.25" cy="-1093.12" rx="18" ry="18"/>
+<text text-anchor="middle" x="1121.25" y="-1089.42" font-family="Times,serif" font-size="14.00">nad_c</text>
+</g>
+<!-- nad_c&#45;&gt;e_0_center -->
+<g id="edge3" class="edge">
+<title>nad_c&#45;&gt;e_0_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1133.56,-1106.56C1157.18,-1132.35 1207.75,-1187.54 1221.5,-1202.56"/>
+</g>
+<!-- nad_c&#45;&gt;e_7_center -->
+<g id="edge27" class="edge">
+<title>nad_c&#45;&gt;e_7_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1139.47,-1094.09C1158.71,-1095.11 1187.66,-1096.64 1197.84,-1097.18"/>
+</g>
+<!-- e_9_center -->
+<g id="node32" class="node">
+<title>e_9_center</title>
+<polygon fill="none" stroke="black" points="1285.28,-1278.77 1278.28,-1278.77 1278.28,-1271.77 1285.28,-1271.77 1285.28,-1278.77"/>
+</g>
+<!-- nad_c&#45;&gt;e_9_center -->
+<g id="edge35" class="edge">
+<title>nad_c&#45;&gt;e_9_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1132.09,-1107.6C1149.52,-1130.6 1185.15,-1176.62 1218.32,-1213.1 1239.91,-1236.83 1268.31,-1263.05 1278.2,-1272.04"/>
+</g>
+<!-- e_12_center -->
+<g id="node49" class="node">
+<title>e_12_center</title>
+<polygon fill="none" stroke="black" points="991.78,-831.32 984.78,-831.32 984.78,-824.32 991.78,-824.32 991.78,-831.32"/>
+</g>
+<!-- nad_c&#45;&gt;e_12_center -->
+<g id="edge61" class="edge">
+<title>nad_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M1113.13,-1076.92C1086.63,-1024.05 1003.57,-858.33 990.12,-831.5"/>
+</g>
+<!-- e_48_center -->
+<g id="node112" class="node">
+<title>e_48_center</title>
+<polygon fill="none" stroke="black" points="1026.69,-850.79 1019.69,-850.79 1019.69,-843.79 1026.69,-843.79 1026.69,-850.79"/>
+</g>
+<!-- nad_c&#45;&gt;e_48_center -->
+<g id="edge151" class="edge">
+<title>nad_c&#45;&gt;e_48_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.27" d="M1114.51,-1076.22C1094.26,-1025.45 1034.73,-876.22 1024.65,-850.94"/>
+</g>
+<!-- e_60_center -->
+<g id="node127" class="node">
+<title>e_60_center</title>
+<polygon fill="none" stroke="black" points="1258.41,-1162.74 1251.41,-1162.74 1251.41,-1155.74 1258.41,-1155.74 1258.41,-1162.74"/>
+</g>
+<!-- nad_c&#45;&gt;e_60_center -->
+<g id="edge210" class="edge">
+<title>nad_c&#45;&gt;e_60_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1137.64,-1101.23C1168.87,-1116.67 1235.23,-1149.5 1251.33,-1157.47"/>
+</g>
+<!-- e_63_center -->
+<g id="node130" class="node">
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+<!-- h_c&#45;&gt;e_15_center -->
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+<!-- h_c&#45;&gt;e_66_center -->
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+<!-- h_c&#45;&gt;e_82_center -->
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+<!-- nadh_c -->
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+<!-- nadh_c&#45;&gt;e_66_center -->
+<g id="edge240" class="edge">
+<title>nadh_c&#45;&gt;e_66_center</title>
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+<!-- nadh_c&#45;&gt;e_91_center -->
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+<!-- accoa_c -->
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+<title>accoa_c</title>
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+<!-- accoa_c&#45;&gt;e_12_center -->
+<g id="edge55" class="edge">
+<title>accoa_c&#45;&gt;e_12_center</title>
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+<!-- e_14_center -->
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+<!-- accoa_c&#45;&gt;e_14_center -->
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+<!-- accoa_c&#45;&gt;e_61_center -->
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+<!-- e_81_center -->
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+<!-- accoa_c&#45;&gt;e_81_center -->
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+<!-- e_0_center&#45;&gt;h_c -->
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+<!-- e_0_center&#45;&gt;nadh_c -->
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+<!-- e_0_center&#45;&gt;accoa_c -->
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+<!-- acald_e -->
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+<!-- acald_e&#45;&gt;acald_c -->
+<g id="edge7" class="edge">
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+<!-- e_20_target -->
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+<title>e_20_target</title>
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+<!-- acald_e&#45;&gt;e_20_target -->
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+<!-- ac_c -->
+<g id="node9" class="node">
+<title>ac_c</title>
+<ellipse fill="none" stroke="black" cx="464.62" cy="-1287.85" rx="18" ry="18"/>
+<text text-anchor="middle" x="464.62" y="-1284.15" font-family="Times,serif" font-size="14.00">ac_c</text>
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+<!-- e_2_center -->
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+<!-- ac_c&#45;&gt;e_2_center -->
+<g id="edge8" class="edge">
+<title>ac_c&#45;&gt;e_2_center</title>
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+</g>
+<!-- atp_c -->
+<g id="node10" class="node">
+<title>atp_c</title>
+<ellipse fill="none" stroke="black" cx="764.47" cy="-882.88" rx="18" ry="18"/>
+<text text-anchor="middle" x="764.47" y="-879.18" font-family="Times,serif" font-size="14.00">atp_c</text>
+</g>
+<!-- atp_c&#45;&gt;e_2_center -->
+<g id="edge9" class="edge">
+<title>atp_c&#45;&gt;e_2_center</title>
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+<!-- e_6_center -->
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+<!-- atp_c&#45;&gt;e_6_center -->
+<g id="edge23" class="edge">
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+<!-- e_10_center -->
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+<!-- atp_c&#45;&gt;e_10_center -->
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+<!-- atp_c&#45;&gt;e_12_center -->
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+<!-- e_50_center -->
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+<!-- atp_c&#45;&gt;e_50_center -->
+<g id="edge160" class="edge">
+<title>atp_c&#45;&gt;e_50_center</title>
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+<!-- e_51_center -->
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+<!-- atp_c&#45;&gt;e_51_center -->
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+<title>atp_c&#45;&gt;e_51_center</title>
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+<!-- e_71_center -->
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+<!-- atp_c&#45;&gt;e_71_center -->
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+<!-- e_74_center -->
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+<!-- atp_c&#45;&gt;e_74_center -->
+<g id="edge267" class="edge">
+<title>atp_c&#45;&gt;e_74_center</title>
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+<!-- e_79_center -->
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+<!-- atp_c&#45;&gt;e_79_center -->
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+<!-- e_80_center -->
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+<polygon fill="none" stroke="black" points="918.47,-862.84 911.47,-862.84 911.47,-855.84 918.47,-855.84 918.47,-862.84"/>
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+<!-- atp_c&#45;&gt;e_80_center -->
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+<!-- atp_c&#45;&gt;e_89_center -->
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+<title>atp_c&#45;&gt;e_89_center</title>
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+<!-- adp_c -->
+<g id="node11" class="node">
+<title>adp_c</title>
+<ellipse fill="none" stroke="black" cx="802.41" cy="-929.72" rx="18" ry="18"/>
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+<!-- e_11_center -->
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+<!-- adp_c&#45;&gt;e_11_center -->
+<g id="edge46" class="edge">
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+<!-- adp_c&#45;&gt;e_82_center -->
+<g id="edge302" class="edge">
+<title>adp_c&#45;&gt;e_82_center</title>
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+<!-- actp_c -->
+<g id="node12" class="node">
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+<ellipse fill="none" stroke="black" cx="476.98" cy="-1151.77" rx="18" ry="18"/>
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+<!-- e_2_center&#45;&gt;adp_c -->
+<g id="edge10" class="edge">
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+<!-- e_2_center&#45;&gt;actp_c -->
+<g id="edge11" class="edge">
+<title>e_2_center&#45;&gt;actp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M560.29,-1052.88C549.79,-1065.34 516.57,-1104.78 495.39,-1129.92"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="492.48,-1127.94 488.71,-1137.84 497.83,-1132.45 492.48,-1127.94"/>
+</g>
+<!-- cit_c -->
+<g id="node14" class="node">
+<title>cit_c</title>
+<ellipse fill="none" stroke="black" cx="499.3" cy="-1028.97" rx="18" ry="18"/>
+<text text-anchor="middle" x="499.3" y="-1025.27" font-family="Times,serif" font-size="14.00">cit_c</text>
+</g>
+<!-- e_3_center -->
+<g id="node17" class="node">
+<title>e_3_center</title>
+<polygon fill="none" stroke="black" points="417.08,-914.83 410.08,-914.83 410.08,-907.83 417.08,-907.83 417.08,-914.83"/>
+</g>
+<!-- cit_c&#45;&gt;e_3_center -->
+<g id="edge12" class="edge">
+<title>cit_c&#45;&gt;e_3_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M488.44,-1014.07C468.44,-986.62 426.83,-929.51 416.13,-914.83"/>
+</g>
+<!-- h2o_c -->
+<g id="node15" class="node">
+<title>h2o_c</title>
+<ellipse fill="none" stroke="black" cx="739.36" cy="-955.4" rx="18" ry="18"/>
+<text text-anchor="middle" x="739.36" y="-951.7" font-family="Times,serif" font-size="14.00">h2o_c</text>
+</g>
+<!-- e_4_center -->
+<g id="node19" class="node">
+<title>e_4_center</title>
+<polygon fill="none" stroke="black" points="439.95,-982.98 432.95,-982.98 432.95,-975.98 439.95,-975.98 439.95,-982.98"/>
+</g>
+<!-- h2o_c&#45;&gt;e_4_center -->
+<g id="edge15" class="edge">
+<title>h2o_c&#45;&gt;e_4_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M721.32,-956.84C661.21,-961.62 469.83,-976.83 440.3,-979.18"/>
+</g>
+<!-- h2o_c&#45;&gt;e_10_center -->
+<g id="edge40" class="edge">
+<title>h2o_c&#45;&gt;e_10_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.75" d="M739.71,-973.62C740.07,-981.96 740.79,-991.95 742.2,-1000.85 745.52,-1021.64 753.03,-1045.83 755.94,-1054.8"/>
+</g>
+<!-- h2o_c&#45;&gt;e_12_center -->
+<g id="edge58" class="edge">
+<title>h2o_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M752.79,-942.83C762.27,-934.41 775.56,-923.5 788.6,-915.81 842.97,-883.71 864.48,-892.8 921.67,-866.04 946.55,-854.4 974.52,-836.74 984.49,-830.29"/>
+</g>
+<!-- h2o_c&#45;&gt;e_14_center -->
+<g id="edge75" class="edge">
+<title>h2o_c&#45;&gt;e_14_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M754.27,-965.8C761.48,-971.42 769.83,-978.88 775.68,-987.03 796.79,-1016.42 804.21,-1061.32 806.02,-1074.63"/>
+</g>
+<!-- e_40_center -->
+<g id="node99" class="node">
+<title>e_40_center</title>
+<polygon fill="none" stroke="black" points="836.01,-709.7 829.01,-709.7 829.01,-702.7 836.01,-702.7 836.01,-709.7"/>
+</g>
+<!-- h2o_c&#45;&gt;e_40_center -->
+<g id="edge121" class="edge">
+<title>h2o_c&#45;&gt;e_40_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M750.42,-940.47C758.69,-928.91 769.96,-912.31 778.26,-896.81 815.47,-827.36 829.52,-729.64 832.06,-709.8"/>
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+<!-- e_45_center -->
+<g id="node107" class="node">
+<title>e_45_center</title>
+<polygon fill="none" stroke="black" points="836.29,-1310.83 829.29,-1310.83 829.29,-1303.83 836.29,-1303.83 836.29,-1310.83"/>
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+<!-- h2o_c&#45;&gt;e_45_center -->
+<g id="edge138" class="edge">
+<title>h2o_c&#45;&gt;e_45_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M739.14,-973.73C739.39,-982.1 740.18,-992.07 742.2,-1000.85 743.7,-1007.34 745.34,-1008.57 747.93,-1014.71 754.87,-1031.2 757.95,-1034.79 763.83,-1051.68 798.88,-1152.41 827.04,-1280.53 832.01,-1303.67"/>
+</g>
+<!-- h2o_c&#45;&gt;e_51_center -->
+<g id="edge167" class="edge">
+<title>h2o_c&#45;&gt;e_51_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M722.21,-961.04C698.41,-968.87 656.89,-982.53 644.49,-986.6"/>
+</g>
+<!-- e_52_center -->
+<g id="node117" class="node">
+<title>e_52_center</title>
+<polygon fill="none" stroke="black" points="883.64,-922.84 876.64,-922.84 876.64,-915.84 883.64,-915.84 883.64,-922.84"/>
+</g>
+<!-- h2o_c&#45;&gt;e_52_center -->
+<g id="edge174" class="edge">
+<title>h2o_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.82" d="M757.49,-954.95C770.19,-954.32 787.48,-952.83 802.34,-949.32 831.92,-942.32 865.32,-926.63 876.37,-921.22"/>
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+<!-- e_53_center -->
+<g id="node118" class="node">
+<title>e_53_center</title>
+<polygon fill="none" stroke="black" points="590.47,-849.61 583.47,-849.61 583.47,-842.61 590.47,-842.61 590.47,-849.61"/>
+</g>
+<!-- h2o_c&#45;&gt;e_53_center -->
+<g id="edge181" class="edge">
+<title>h2o_c&#45;&gt;e_53_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M724.97,-944.59C721.42,-941.95 717.62,-939.14 714.08,-936.57 665.48,-901.17 605.58,-859.14 590.53,-848.6"/>
+</g>
+<!-- h2o_c&#45;&gt;e_61_center -->
+<g id="edge214" class="edge">
+<title>h2o_c&#45;&gt;e_61_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M754.18,-965.86C761.37,-971.5 769.73,-978.96 775.68,-987.03 828.36,-1058.46 855.18,-1167.24 860.09,-1188.59"/>
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+<!-- e_75_center -->
+<g id="node139" class="node">
+<title>e_75_center</title>
+<polygon fill="none" stroke="black" points="1093.25,-899.51 1086.25,-899.51 1086.25,-892.51 1093.25,-892.51 1093.25,-899.51"/>
+</g>
+<!-- h2o_c&#45;&gt;e_75_center -->
+<g id="edge271" class="edge">
+<title>h2o_c&#45;&gt;e_75_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M757.33,-954.09C769.96,-953.06 787.22,-951.45 802.34,-949.32 889.72,-936.98 910.77,-929.03 997.54,-912.97 1032.11,-906.58 1073.99,-898.9 1086.23,-896.66"/>
+</g>
+<!-- e_78_center -->
+<g id="node141" class="node">
+<title>e_78_center</title>
+<polygon fill="none" stroke="black" points="1007.74,-923.17 1000.74,-923.17 1000.74,-916.17 1007.74,-916.17 1007.74,-923.17"/>
+</g>
+<!-- h2o_c&#45;&gt;e_78_center -->
+<g id="edge280" class="edge">
+<title>h2o_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.84" d="M757.31,-953.91C769.92,-952.8 787.18,-951.16 802.34,-949.32 882.88,-939.52 980.89,-923.53 1000.67,-920.27"/>
+</g>
+<!-- h2o_c&#45;&gt;e_80_center -->
+<g id="edge291" class="edge">
+<title>h2o_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.78" d="M752.87,-942.95C762.39,-934.59 775.68,-923.7 788.6,-915.81 834.11,-887.98 895.72,-865.95 911.28,-860.59"/>
+</g>
+<!-- acon_C_c -->
+<g id="node16" class="node">
+<title>acon_C_c</title>
+<ellipse fill="none" stroke="black" cx="210.14" cy="-912.3" rx="18" ry="18"/>
+<text text-anchor="middle" x="210.14" y="-908.6" font-family="Times,serif" font-size="14.00">acon_C_c</text>
+</g>
+<!-- acon_C_c&#45;&gt;e_4_center -->
+<g id="edge16" class="edge">
+<title>acon_C_c&#45;&gt;e_4_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M225.9,-921.16C235.46,-926.41 247.96,-933.07 259.33,-938.43 324.42,-969.14 414.07,-977.71 432.9,-979.22"/>
+</g>
+<!-- e_3_center&#45;&gt;h2o_c -->
+<g id="edge13" class="edge">
+<title>e_3_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M417.24,-911.82C446.1,-915.73 637.82,-941.67 711.03,-951.57"/>
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+<!-- e_3_center&#45;&gt;acon_C_c -->
+<g id="edge14" class="edge">
+<title>e_3_center&#45;&gt;acon_C_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M409.68,-910.92C393.15,-909.25 327.34,-903.08 273.22,-904.98 261.74,-905.39 249.14,-906.68 238.25,-908.06"/>
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+</g>
+<!-- icit_c -->
+<g id="node18" class="node">
+<title>icit_c</title>
+<ellipse fill="none" stroke="black" cx="634.63" cy="-1119.02" rx="18" ry="18"/>
+<text text-anchor="middle" x="634.63" y="-1115.32" font-family="Times,serif" font-size="14.00">icit_c</text>
+</g>
+<!-- e_58_center -->
+<g id="node124" class="node">
+<title>e_58_center</title>
+<polygon fill="none" stroke="black" points="987.48,-989.78 980.48,-989.78 980.48,-982.78 987.48,-982.78 987.48,-989.78"/>
+</g>
+<!-- icit_c&#45;&gt;e_58_center -->
+<g id="edge201" class="edge">
+<title>icit_c&#45;&gt;e_58_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M651.95,-1113.19C699.92,-1096.97 838.54,-1049.68 952.32,-1006.48 958.56,-1004.12 960.5,-1004.25 966.23,-1000.85 971.57,-997.67 976.99,-992.96 980.41,-989.76"/>
+</g>
+<!-- e_59_center -->
+<g id="node126" class="node">
+<title>e_59_center</title>
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+</g>
+<!-- icit_c&#45;&gt;e_59_center -->
+<g id="edge206" class="edge">
+<title>icit_c&#45;&gt;e_59_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M626.76,-1135.53C602.74,-1185.9 531.29,-1335.74 519.19,-1361.12"/>
+</g>
+<!-- e_4_center&#45;&gt;icit_c -->
+<g id="edge17" class="edge">
+<title>e_4_center&#45;&gt;icit_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M440.19,-980.74C451.69,-984.73 487.37,-997.81 513.24,-1015.19 535.2,-1029.95 536.91,-1038.32 556.88,-1055.68 575.17,-1071.58 596.56,-1088.92 612.27,-1101.43"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.26" points="610.35,-1104.37 620.36,-1107.84 614.69,-1098.89 610.35,-1104.37"/>
+</g>
+<!-- ac_e -->
+<g id="node20" class="node">
+<title>ac_e</title>
+<ellipse fill="none" stroke="black" cx="416.75" cy="-1683.11" rx="18" ry="18"/>
+<text text-anchor="middle" x="416.75" y="-1679.41" font-family="Times,serif" font-size="14.00">ac_e</text>
+</g>
+<!-- e_5_center -->
+<g id="node22" class="node">
+<title>e_5_center</title>
+<polygon fill="none" stroke="black" points="689.94,-1435.26 682.94,-1435.26 682.94,-1428.26 689.94,-1428.26 689.94,-1435.26"/>
+</g>
+<!-- ac_e&#45;&gt;e_5_center -->
+<g id="edge18" class="edge">
+<title>ac_e&#45;&gt;e_5_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M430.13,-1670.65C480.29,-1623.89 655.8,-1460.32 682.91,-1435.05"/>
+</g>
+<!-- e_19_target -->
+<g id="node63" class="node">
+<title>e_19_target</title>
+<ellipse fill="black" stroke="black" cx="227.74" cy="-1865.27" rx="1.8" ry="1.8"/>
+</g>
+<!-- ac_e&#45;&gt;e_19_target -->
+<g id="edge98" class="edge">
+<title>ac_e&#45;&gt;e_19_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M403.76,-1695.63C367.79,-1730.29 267.54,-1826.91 236.81,-1856.53"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="234.02,-1854.36 229.24,-1863.82 238.87,-1859.4 234.02,-1854.36"/>
+</g>
+<!-- h_e -->
+<g id="node21" class="node">
+<title>h_e</title>
+<ellipse fill="none" stroke="black" cx="991.51" cy="-1388.89" rx="18" ry="18"/>
+<text text-anchor="middle" x="991.51" y="-1385.19" font-family="Times,serif" font-size="14.00">h_e</text>
+</g>
+<!-- h_e&#45;&gt;e_5_center -->
+<g id="edge19" class="edge">
+<title>h_e&#45;&gt;e_5_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M973.34,-1391.44C912.54,-1399.98 718.43,-1427.27 689.95,-1431.27"/>
+</g>
+<!-- e_8_center -->
+<g id="node30" class="node">
+<title>e_8_center</title>
+<polygon fill="none" stroke="black" points="1202.34,-1379.26 1195.34,-1379.26 1195.34,-1372.26 1202.34,-1372.26 1202.34,-1379.26"/>
+</g>
+<!-- h_e&#45;&gt;e_8_center -->
+<g id="edge31" class="edge">
+<title>h_e&#45;&gt;e_8_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1009.55,-1387.74C1055.06,-1384.86 1172.56,-1377.43 1195.08,-1376"/>
+</g>
+<!-- h_e&#45;&gt;e_11_center -->
+<g id="edge47" class="edge">
+<title>h_e&#45;&gt;e_11_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M981.48,-1373.54C976.8,-1366.21 971.26,-1357.24 966.62,-1348.98 915.08,-1257.25 860.55,-1140.24 850.39,-1118.26"/>
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+<!-- e_16_center -->
+<g id="node58" class="node">
+<title>e_16_center</title>
+<polygon fill="none" stroke="black" points="1224.69,-1500.08 1217.69,-1500.08 1217.69,-1493.08 1224.69,-1493.08 1224.69,-1500.08"/>
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+<!-- h_e&#45;&gt;e_16_center -->
+<g id="edge87" class="edge">
+<title>h_e&#45;&gt;e_16_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1008.03,-1396.63C1055.96,-1419.1 1193.22,-1483.46 1217.49,-1494.85"/>
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+<!-- e_18_center -->
+<g id="node62" class="node">
+<title>e_18_center</title>
+<polygon fill="none" stroke="black" points="1172.85,-1550.08 1165.85,-1550.08 1165.85,-1543.08 1172.85,-1543.08 1172.85,-1550.08"/>
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+<!-- h_e&#45;&gt;e_18_center -->
+<g id="edge94" class="edge">
+<title>h_e&#45;&gt;e_18_center</title>
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+<!-- e_30_target -->
+<g id="node80" class="node">
+<title>e_30_target</title>
+<ellipse fill="black" stroke="black" cx="1050.19" cy="-1667.04" rx="1.8" ry="1.8"/>
+</g>
+<!-- h_e&#45;&gt;e_30_target -->
+<g id="edge109" class="edge">
+<title>h_e&#45;&gt;e_30_target</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.04" d="M995.27,-1406.71C1006.3,-1458.98 1038.36,-1610.97 1047.64,-1654.97"/>
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+<!-- e_41_center -->
+<g id="node101" class="node">
+<title>e_41_center</title>
+<polygon fill="none" stroke="black" points="1277.74,-1407.87 1270.74,-1407.87 1270.74,-1400.87 1277.74,-1400.87 1277.74,-1407.87"/>
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+<!-- h_e&#45;&gt;e_41_center -->
+<g id="edge126" class="edge">
+<title>h_e&#45;&gt;e_41_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1009.63,-1389.88C1067.15,-1393.03 1243.5,-1402.68 1270.7,-1404.17"/>
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+<!-- e_46_center -->
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+<!-- h_e&#45;&gt;e_46_center -->
+<g id="edge141" class="edge">
+<title>h_e&#45;&gt;e_46_center</title>
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+<!-- e_55_center -->
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+<!-- h_e&#45;&gt;e_55_center -->
+<g id="edge191" class="edge">
+<title>h_e&#45;&gt;e_55_center</title>
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+<!-- e_62_center -->
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+<!-- h_e&#45;&gt;e_62_center -->
+<g id="edge220" class="edge">
+<title>h_e&#45;&gt;e_62_center</title>
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+<!-- e_77_center -->
+<g id="node140" class="node">
+<title>e_77_center</title>
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+<!-- h_e&#45;&gt;e_77_center -->
+<g id="edge276" class="edge">
+<title>h_e&#45;&gt;e_77_center</title>
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+<!-- e_83_center -->
+<g id="node146" class="node">
+<title>e_83_center</title>
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+<!-- h_e&#45;&gt;e_83_center -->
+<g id="edge307" class="edge">
+<title>h_e&#45;&gt;e_83_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1007.03,-1379.08C1063.24,-1343.55 1254.49,-1222.67 1284.03,-1204"/>
+</g>
+<!-- e_86_center -->
+<g id="node148" class="node">
+<title>e_86_center</title>
+<polygon fill="none" stroke="black" points="908.34,-1524.24 901.34,-1524.24 901.34,-1517.24 908.34,-1517.24 908.34,-1524.24"/>
+</g>
+<!-- h_e&#45;&gt;e_86_center -->
+<g id="edge314" class="edge">
+<title>h_e&#45;&gt;e_86_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M981.57,-1404.01C961.65,-1434.32 917.85,-1500.96 907.21,-1517.14"/>
+</g>
+<!-- e_87_center -->
+<g id="node149" class="node">
+<title>e_87_center</title>
+<polygon fill="none" stroke="black" points="880.82,-1511.72 873.82,-1511.72 873.82,-1504.72 880.82,-1504.72 880.82,-1511.72"/>
+</g>
+<!-- h_e&#45;&gt;e_87_center -->
+<g id="edge317" class="edge">
+<title>h_e&#45;&gt;e_87_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M978.85,-1402.11C953.07,-1429.06 895.65,-1489.07 880.85,-1504.53"/>
+</g>
+<!-- h_e&#45;&gt;e_91_center -->
+<g id="edge336" class="edge">
+<title>h_e&#45;&gt;e_91_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M999.68,-1372.66C1025.01,-1322.36 1101.28,-1170.93 1114.2,-1145.27"/>
+</g>
+<!-- e_5_center&#45;&gt;h_c -->
+<g id="edge21" class="edge">
+<title>e_5_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M690.22,-1429.65C700.12,-1424.07 727.53,-1408.24 748.65,-1392.59 832.48,-1330.5 922.1,-1244.38 961.07,-1205.82"/>
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+</g>
+<!-- e_5_center&#45;&gt;ac_c -->
+<g id="edge20" class="edge">
+<title>e_5_center&#45;&gt;ac_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M682.59,-1429.26C659.64,-1414.37 540.06,-1336.79 488.42,-1303.29"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="490.18,-1300.26 479.89,-1297.75 486.37,-1306.13 490.18,-1300.26"/>
+</g>
+<!-- amp_c -->
+<g id="node23" class="node">
+<title>amp_c</title>
+<ellipse fill="none" stroke="black" cx="698.26" cy="-637.56" rx="18" ry="18"/>
+<text text-anchor="middle" x="698.26" y="-633.86" font-family="Times,serif" font-size="14.00">amp_c</text>
+</g>
+<!-- amp_c&#45;&gt;e_6_center -->
+<g id="edge22" class="edge">
+<title>amp_c&#45;&gt;e_6_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.78" d="M688.82,-653.04C673.31,-678.5 643.28,-727.76 634.71,-741.82"/>
+</g>
+<!-- e_6_center&#45;&gt;adp_c -->
+<g id="edge24" class="edge">
+<title>e_6_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.78" d="M634.57,-749.3C645.39,-767.12 694.83,-846.1 750.54,-896.67 758.52,-903.91 768.27,-910.58 777.16,-916"/>
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+</g>
+<!-- akg_c -->
+<g id="node25" class="node">
+<title>akg_c</title>
+<ellipse fill="none" stroke="black" cx="1069.22" cy="-1067.79" rx="18" ry="18"/>
+<text text-anchor="middle" x="1069.22" y="-1064.09" font-family="Times,serif" font-size="14.00">akg_c</text>
+</g>
+<!-- akg_c&#45;&gt;e_7_center -->
+<g id="edge26" class="edge">
+<title>akg_c&#45;&gt;e_7_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1087.21,-1068.96C1097.32,-1069.82 1110.13,-1071.25 1121.38,-1073.52 1125.33,-1074.32 1182.71,-1091.67 1197.88,-1096.27"/>
+</g>
+<!-- akg_c&#45;&gt;e_54_center -->
+<g id="edge185" class="edge">
+<title>akg_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1054.01,-1058.15C1034.42,-1045.17 1000.17,-1020.51 977.28,-992.98 970.85,-985.25 973.21,-980.55 966.44,-973.13 960.53,-966.67 951.5,-961.55 946.43,-958.99"/>
+</g>
+<!-- co2_c -->
+<g id="node26" class="node">
+<title>co2_c</title>
+<ellipse fill="none" stroke="black" cx="1257.36" cy="-864.4" rx="18" ry="18"/>
+<text text-anchor="middle" x="1257.36" y="-860.7" font-family="Times,serif" font-size="14.00">co2_c</text>
+</g>
+<!-- co2_c&#45;&gt;e_78_center -->
+<g id="edge281" class="edge">
+<title>co2_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.84" d="M1239.49,-860.46C1230.09,-858.91 1218.38,-857.83 1207.97,-859.31 1169.3,-864.83 1166,-885.88 1128.52,-896.88 1081.79,-910.6 1022.65,-917.67 1007.76,-919.3"/>
+</g>
+<!-- succoa_c -->
+<g id="node27" class="node">
+<title>succoa_c</title>
+<ellipse fill="none" stroke="black" cx="1023.77" cy="-1259.8" rx="18" ry="18"/>
+<text text-anchor="middle" x="1023.77" y="-1256.1" font-family="Times,serif" font-size="14.00">succoa_c</text>
+</g>
+<!-- e_7_center&#45;&gt;nadh_c -->
+<g id="edge30" class="edge">
+<title>e_7_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1197.94,-1094.32C1195.21,-1092.01 1191.22,-1088.63 1186.96,-1085.01"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1189.11,-1082.24 1179.22,-1078.44 1184.58,-1087.58 1189.11,-1082.24"/>
+</g>
+<!-- e_7_center&#45;&gt;co2_c -->
+<g id="edge28" class="edge">
+<title>e_7_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1202.41,-1093.72C1207.87,-1070.93 1237.41,-947.64 1250.78,-891.85"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1254.23,-892.49 1253.15,-881.95 1247.42,-890.85 1254.23,-892.49"/>
+</g>
+<!-- e_7_center&#45;&gt;succoa_c -->
+<g id="edge29" class="edge">
+<title>e_7_center&#45;&gt;succoa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1197.82,-1100.77C1178.24,-1118.66 1086.31,-1202.65 1044.53,-1240.83"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1042.13,-1238.28 1037.11,-1247.61 1046.85,-1243.45 1042.13,-1238.28"/>
+</g>
+<!-- akg_e -->
+<g id="node29" class="node">
+<title>akg_e</title>
+<ellipse fill="none" stroke="black" cx="1460.4" cy="-1630.69" rx="18" ry="18"/>
+<text text-anchor="middle" x="1460.4" y="-1626.99" font-family="Times,serif" font-size="14.00">akg_e</text>
+</g>
+<!-- akg_e&#45;&gt;e_8_center -->
+<g id="edge32" class="edge">
+<title>akg_e&#45;&gt;e_8_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1446.27,-1618.85C1425.54,-1601.34 1385.86,-1567.28 1353.75,-1536.54 1290.47,-1475.96 1218.19,-1397.04 1202.11,-1379.38"/>
+</g>
+<!-- e_21_target -->
+<g id="node65" class="node">
+<title>e_21_target</title>
+<ellipse fill="black" stroke="black" cx="1658.89" cy="-1816.17" rx="1.8" ry="1.8"/>
+</g>
+<!-- akg_e&#45;&gt;e_21_target -->
+<g id="edge100" class="edge">
+<title>akg_e&#45;&gt;e_21_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1473.73,-1643.15C1511.38,-1678.33 1617.84,-1777.81 1649.75,-1807.62"/>
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+</g>
+<!-- e_8_center&#45;&gt;h_c -->
+<g id="edge34" class="edge">
+<title>e_8_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1195.06,-1372.47C1172.21,-1352.53 1051.91,-1247.56 1002.39,-1204.36"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1004.65,-1201.68 994.81,-1197.74 1000.04,-1206.95 1004.65,-1201.68"/>
+</g>
+<!-- e_8_center&#45;&gt;akg_c -->
+<g id="edge33" class="edge">
+<title>e_8_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1197.2,-1371.87C1185.08,-1343.07 1109,-1162.32 1080.23,-1093.95"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1083.44,-1092.56 1076.34,-1084.7 1076.99,-1095.28 1083.44,-1092.56"/>
+</g>
+<!-- etoh_c -->
+<g id="node31" class="node">
+<title>etoh_c</title>
+<ellipse fill="none" stroke="black" cx="1367.72" cy="-1522.79" rx="18" ry="18"/>
+<text text-anchor="middle" x="1367.72" y="-1519.09" font-family="Times,serif" font-size="14.00">etoh_c</text>
+</g>
+<!-- etoh_c&#45;&gt;e_9_center -->
+<g id="edge36" class="edge">
+<title>etoh_c&#45;&gt;e_9_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1361.81,-1505.78C1344.06,-1454.66 1291.9,-1304.4 1283.06,-1278.96"/>
+</g>
+<!-- e_9_center&#45;&gt;acald_c -->
+<g id="edge37" class="edge">
+<title>e_9_center&#45;&gt;acald_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1285.68,-1275.97C1312.04,-1280.66 1465.07,-1307.91 1529.21,-1319.32"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1528.95,-1322.83 1539.41,-1321.14 1530.17,-1315.94 1528.95,-1322.83"/>
+</g>
+<!-- e_9_center&#45;&gt;h_c -->
+<g id="edge39" class="edge">
+<title>e_9_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1277.98,-1274.14C1250.1,-1265.84 1076.43,-1214.14 1008.38,-1193.88"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1008.98,-1190.41 998.4,-1190.91 1006.98,-1197.12 1008.98,-1190.41"/>
+</g>
+<!-- e_9_center&#45;&gt;nadh_c -->
+<g id="edge38" class="edge">
+<title>e_9_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1279.76,-1271.65C1267.91,-1250.41 1206.95,-1141.19 1179.18,-1091.44"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1182.18,-1089.63 1174.25,-1082.61 1176.07,-1093.04 1182.18,-1089.63"/>
+</g>
+<!-- pi_c -->
+<g id="node33" class="node">
+<title>pi_c</title>
+<ellipse fill="none" stroke="black" cx="831.73" cy="-982.39" rx="18" ry="18"/>
+<text text-anchor="middle" x="831.73" y="-978.69" font-family="Times,serif" font-size="14.00">pi_c</text>
+</g>
+<!-- pi_c&#45;&gt;e_11_center -->
+<g id="edge45" class="edge">
+<title>pi_c&#45;&gt;e_11_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M834.06,-1000.49C838.09,-1031.9 846.15,-1094.65 848.22,-1110.77"/>
+</g>
+<!-- pi_c&#45;&gt;e_48_center -->
+<g id="edge150" class="edge">
+<title>pi_c&#45;&gt;e_48_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.27" d="M846.76,-971.79C887.48,-943.05 998.37,-864.8 1019.64,-849.79"/>
+</g>
+<!-- pi_c&#45;&gt;e_81_center -->
+<g id="edge298" class="edge">
+<title>pi_c&#45;&gt;e_81_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M823.63,-998.48C807.19,-1031.13 770.71,-1103.58 761.84,-1121.18"/>
+</g>
+<!-- e_10_center&#45;&gt;h_c -->
+<g id="edge44" class="edge">
+<title>e_10_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.75" d="M761,-1061.13C768.33,-1066.27 784.85,-1077.51 799.79,-1085.18 823.55,-1097.38 831.62,-1095.79 855.41,-1107.91 892.47,-1126.8 932.98,-1152.98 957.71,-1169.64"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.75" points="955.83,-1172.59 966.07,-1175.32 959.76,-1166.8 955.83,-1172.59"/>
+</g>
+<!-- e_10_center&#45;&gt;adp_c -->
+<g id="edge43" class="edge">
+<title>e_10_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.75" d="M758.68,-1054.77C761.87,-1047.3 769.4,-1029.62 775.65,-1014.75 778.23,-1008.6 779.18,-1007.18 781.4,-1000.9 786.46,-986.62 791.31,-970.44 795.06,-957.12"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.75" points="798.53,-957.71 797.83,-947.14 791.79,-955.84 798.53,-957.71"/>
+</g>
+<!-- e_10_center&#45;&gt;pi_c -->
+<g id="edge42" class="edge">
+<title>e_10_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.75" d="M760.73,-1054.72C769.8,-1045.48 794.11,-1020.71 811.77,-1002.73"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.75" points="814.35,-1005.09 818.86,-995.5 809.36,-1000.18 814.35,-1005.09"/>
+</g>
+<!-- e_11_center&#45;&gt;h_c -->
+<g id="edge50" class="edge">
+<title>e_11_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M852.25,-1116.51C866.77,-1124.32 922.54,-1154.29 955.75,-1172.15"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="953.99,-1176.16 964.87,-1177.04 958.13,-1168.46 953.99,-1176.16"/>
+</g>
+<!-- e_11_center&#45;&gt;atp_c -->
+<g id="edge49" class="edge">
+<title>e_11_center&#45;&gt;atp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M847.39,-1110.97C839.11,-1088.2 794.17,-964.57 774.13,-909.44"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="778.22,-907.89 770.69,-899.98 769.99,-910.88 778.22,-907.89"/>
+</g>
+<!-- e_11_center&#45;&gt;h2o_c -->
+<g id="edge48" class="edge">
+<title>e_11_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M847.09,-1110.78C840.15,-1094.61 811.62,-1030.83 775.68,-987.03 771.6,-982.06 766.7,-977.22 761.84,-972.89"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="764.3,-969.24 753.83,-966.13 758.65,-975.93 764.3,-969.24"/>
+</g>
+<!-- gln__L_c -->
+<g id="node36" class="node">
+<title>gln__L_c</title>
+<ellipse fill="none" stroke="black" cx="748.84" cy="-827.41" rx="18" ry="18"/>
+<text text-anchor="middle" x="748.84" y="-823.71" font-family="Times,serif" font-size="14.00">gln__L_c</text>
+</g>
+<!-- gln__L_c&#45;&gt;e_12_center -->
+<g id="edge51" class="edge">
+<title>gln__L_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M767.23,-827.44C818.26,-827.53 959.51,-827.77 984.48,-827.81"/>
+</g>
+<!-- gln__L_c&#45;&gt;e_53_center -->
+<g id="edge182" class="edge">
+<title>gln__L_c&#45;&gt;e_53_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M730.9,-829.49C693.69,-833.78 610.01,-843.45 590.91,-845.66"/>
+</g>
+<!-- gln__L_c&#45;&gt;e_54_center -->
+<g id="edge187" class="edge">
+<title>gln__L_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M764.54,-836.28C790.57,-851.16 844.01,-882.49 886.84,-912.64 907.31,-927.05 930.22,-946.45 938.97,-954"/>
+</g>
+<!-- 3pg_c -->
+<g id="node37" class="node">
+<title>3pg_c</title>
+<ellipse fill="none" stroke="black" cx="815.53" cy="-556.84" rx="18" ry="18"/>
+<text text-anchor="middle" x="815.53" y="-553.14" font-family="Times,serif" font-size="14.00">3pg_c</text>
+</g>
+<!-- 3pg_c&#45;&gt;e_12_center -->
+<g id="edge52" class="edge">
+<title>3pg_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M825.31,-572.18C858.86,-624.81 968.14,-796.23 985.84,-824"/>
+</g>
+<!-- 3pg_c&#45;&gt;e_74_center -->
+<g id="edge268" class="edge">
+<title>3pg_c&#45;&gt;e_74_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.27" d="M806.73,-572.76C789.53,-603.87 752.36,-671.11 743.33,-687.43"/>
+</g>
+<!-- f6p_c -->
+<g id="node38" class="node">
+<title>f6p_c</title>
+<ellipse fill="none" stroke="black" cx="1038.14" cy="-546.2" rx="18" ry="18"/>
+<text text-anchor="middle" x="1038.14" y="-542.5" font-family="Times,serif" font-size="14.00">f6p_c</text>
+</g>
+<!-- f6p_c&#45;&gt;e_12_center -->
+<g id="edge53" class="edge">
+<title>f6p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M1034.94,-564.24C1024.8,-621.54 993.7,-797.19 988.9,-824.29"/>
+</g>
+<!-- f6p_c&#45;&gt;e_71_center -->
+<g id="edge258" class="edge">
+<title>f6p_c&#45;&gt;e_71_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.77" d="M1029.09,-561.84C1001.06,-610.32 916.67,-756.28 902.38,-781.01"/>
+</g>
+<!-- pyr_c -->
+<g id="node39" class="node">
+<title>pyr_c</title>
+<ellipse fill="none" stroke="black" cx="1207.84" cy="-878.91" rx="18" ry="18"/>
+<text text-anchor="middle" x="1207.84" y="-875.21" font-family="Times,serif" font-size="14.00">pyr_c</text>
+</g>
+<!-- pyr_c&#45;&gt;e_12_center -->
+<g id="edge54" class="edge">
+<title>pyr_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M1190.29,-873.93C1174.28,-869.45 1149.95,-862.8 1128.63,-857.68 1074.85,-844.76 1008.8,-831.79 992.2,-828.57"/>
+</g>
+<!-- pyr_c&#45;&gt;e_70_center -->
+<g id="edge252" class="edge">
+<title>pyr_c&#45;&gt;e_70_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.7" d="M1210.23,-897.07C1210.72,-901.54 1211.17,-906.31 1211.41,-910.76 1213.22,-942.96 1202.52,-981.25 1198.96,-992.95"/>
+</g>
+<!-- pyr_c&#45;&gt;e_72_center -->
+<g id="edge263" class="edge">
+<title>pyr_c&#45;&gt;e_72_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1213.13,-896.28C1228.55,-946.89 1272.84,-1092.24 1280.34,-1116.84"/>
+</g>
+<!-- pyr_c&#45;&gt;e_80_center -->
+<g id="edge292" class="edge">
+<title>pyr_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.78" d="M1190.8,-872.91C1174.94,-867.67 1150.52,-860.48 1128.63,-857.68 1085.58,-852.18 942.71,-858.12 918.48,-859.18"/>
+</g>
+<!-- r5p_c -->
+<g id="node40" class="node">
+<title>r5p_c</title>
+<ellipse fill="none" stroke="black" cx="1123.47" cy="-472.63" rx="18" ry="18"/>
+<text text-anchor="middle" x="1123.47" y="-468.93" font-family="Times,serif" font-size="14.00">r5p_c</text>
+</g>
+<!-- r5p_c&#45;&gt;e_12_center -->
+<g id="edge56" class="edge">
+<title>r5p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M1116.95,-489.76C1091.85,-555.72 1002.2,-791.22 989.72,-824.01"/>
+</g>
+<!-- ru5p__D_c -->
+<g id="node122" class="node">
+<title>ru5p__D_c</title>
+<ellipse fill="none" stroke="black" cx="1303.98" cy="-377.26" rx="18" ry="18"/>
+<text text-anchor="middle" x="1303.98" y="-373.56" font-family="Times,serif" font-size="14.00">ru5p__D_c</text>
+</g>
+<!-- r5p_c&#45;&gt;ru5p__D_c -->
+<g id="edge312" class="edge">
+<title>r5p_c&#45;&gt;ru5p__D_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.05" d="M1139.49,-464.16C1170.94,-447.55 1240.95,-410.56 1278.7,-390.62"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.05" points="1280.79,-393.47 1288,-385.71 1277.52,-387.29 1280.79,-393.47"/>
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+<!-- e_92_center -->
+<g id="node155" class="node">
+<title>e_92_center</title>
+<polygon fill="none" stroke="black" points="1120.35,-228.53 1113.35,-228.53 1113.35,-221.53 1120.35,-221.53 1120.35,-228.53"/>
+</g>
+<!-- r5p_c&#45;&gt;e_92_center -->
+<g id="edge342" class="edge">
+<title>r5p_c&#45;&gt;e_92_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.91" d="M1123.76,-454.27C1124.14,-423.75 1124.57,-360.65 1122.57,-307.31 1121.43,-276.97 1118.26,-240.45 1117.2,-228.79"/>
+</g>
+<!-- e4p_c -->
+<g id="node41" class="node">
+<title>e4p_c</title>
+<ellipse fill="none" stroke="black" cx="1053.21" cy="-471.31" rx="18" ry="18"/>
+<text text-anchor="middle" x="1053.21" y="-467.61" font-family="Times,serif" font-size="14.00">e4p_c</text>
+</g>
+<!-- e4p_c&#45;&gt;e_12_center -->
+<g id="edge57" class="edge">
+<title>e4p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M1055.8,-489.2C1057.65,-504.4 1059.51,-526.78 1057.74,-546.26 1047.11,-663.08 998.29,-800.49 989.6,-824.23"/>
+</g>
+<!-- e_93_center -->
+<g id="node156" class="node">
+<title>e_93_center</title>
+<polygon fill="none" stroke="black" points="1119.37,-317.51 1112.37,-317.51 1112.37,-310.51 1119.37,-310.51 1119.37,-317.51"/>
+</g>
+<!-- e4p_c&#45;&gt;e_93_center -->
+<g id="edge345" class="edge">
+<title>e4p_c&#45;&gt;e_93_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.85" d="M1059.91,-454.47C1074.18,-418.65 1106.87,-336.6 1114.33,-317.87"/>
+</g>
+<!-- g3p_c -->
+<g id="node42" class="node">
+<title>g3p_c</title>
+<ellipse fill="none" stroke="black" cx="1005.27" cy="-459.71" rx="18" ry="18"/>
+<text text-anchor="middle" x="1005.27" y="-456.01" font-family="Times,serif" font-size="14.00">g3p_c</text>
+</g>
+<!-- g3p_c&#45;&gt;e_12_center -->
+<g id="edge59" class="edge">
+<title>g3p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M1004.44,-477.71C1001.25,-546.71 989.93,-792.02 988.44,-824.3"/>
+</g>
+<!-- g3p_c&#45;&gt;e_48_center -->
+<g id="edge152" class="edge">
+<title>g3p_c&#45;&gt;e_48_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.27" d="M1006.11,-477.88C1009.42,-549.42 1021.44,-809.35 1023.02,-843.56"/>
+</g>
+<!-- e_90_center -->
+<g id="node153" class="node">
+<title>e_90_center</title>
+<polygon fill="none" stroke="black" points="1050.03,-283.06 1043.03,-283.06 1043.03,-276.06 1050.03,-276.06 1050.03,-283.06"/>
+</g>
+<!-- g3p_c&#45;&gt;e_90_center -->
+<g id="edge332" class="edge">
+<title>g3p_c&#45;&gt;e_90_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.91" d="M1009.3,-442.11C1018.59,-401.56 1041.05,-303.48 1045.68,-283.25"/>
+</g>
+<!-- g6p_c -->
+<g id="node43" class="node">
+<title>g6p_c</title>
+<ellipse fill="none" stroke="black" cx="1195.72" cy="-670.74" rx="18" ry="18"/>
+<text text-anchor="middle" x="1195.72" y="-667.04" font-family="Times,serif" font-size="14.00">g6p_c</text>
+</g>
+<!-- g6p_c&#45;&gt;f6p_c -->
+<g id="edge266" class="edge">
+<title>g6p_c&#45;&gt;f6p_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.4" d="M1181.45,-659.47C1154.05,-637.81 1093.85,-590.23 1060.86,-564.15"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.4" points="1062.72,-561.17 1052.71,-557.71 1058.38,-566.66 1062.72,-561.17"/>
+</g>
+<!-- g6p_c&#45;&gt;e_12_center -->
+<g id="edge60" class="edge">
+<title>g6p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M1181.13,-681.78C1138.34,-714.19 1014.72,-807.79 991.92,-825.06"/>
+</g>
+<!-- e_47_center -->
+<g id="node110" class="node">
+<title>e_47_center</title>
+<polygon fill="none" stroke="black" points="1208.21,-920.96 1201.21,-920.96 1201.21,-913.96 1208.21,-913.96 1208.21,-920.96"/>
+</g>
+<!-- g6p_c&#45;&gt;e_47_center -->
+<g id="edge146" class="edge">
+<title>g6p_c&#45;&gt;e_47_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1192.55,-688.72C1186.73,-725 1175.97,-809.38 1188.24,-878.78 1190.63,-892.29 1198.39,-906.82 1202.35,-913.58"/>
+</g>
+<!-- pep_c -->
+<g id="node44" class="node">
+<title>pep_c</title>
+<ellipse fill="none" stroke="black" cx="1071.25" cy="-682.94" rx="18" ry="18"/>
+<text text-anchor="middle" x="1071.25" y="-679.24" font-family="Times,serif" font-size="14.00">pep_c</text>
+</g>
+<!-- pep_c&#45;&gt;e_12_center -->
+<g id="edge62" class="edge">
+<title>pep_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M1062.21,-698.72C1043.22,-731.87 1000.14,-807.1 990.3,-824.28"/>
+</g>
+<!-- e_44_center -->
+<g id="node105" class="node">
+<title>e_44_center</title>
+<polygon fill="none" stroke="black" points="1274.78,-525.21 1267.78,-525.21 1267.78,-518.21 1274.78,-518.21 1274.78,-525.21"/>
+</g>
+<!-- pep_c&#45;&gt;e_44_center -->
+<g id="edge135" class="edge">
+<title>pep_c&#45;&gt;e_44_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1085.31,-671.6C1126.57,-638.34 1245.78,-542.26 1267.77,-524.53"/>
+</g>
+<!-- e_49_center -->
+<g id="node113" class="node">
+<title>e_49_center</title>
+<polygon fill="none" stroke="black" points="1359.54,-592.38 1352.54,-592.38 1352.54,-585.38 1359.54,-585.38 1359.54,-592.38"/>
+</g>
+<!-- pep_c&#45;&gt;e_49_center -->
+<g id="edge157" class="edge">
+<title>pep_c&#45;&gt;e_49_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.3" d="M1088.63,-677.19C1145.63,-658.37 1324.79,-599.2 1352.44,-590.07"/>
+</g>
+<!-- pep_c&#45;&gt;e_78_center -->
+<g id="edge282" class="edge">
+<title>pep_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.84" d="M1067.79,-700.63C1061.5,-731.92 1047.22,-798.9 1029.89,-853.99 1022.25,-878.28 1010.09,-906.46 1005.8,-916.17"/>
+</g>
+<!-- pep_c&#45;&gt;e_82_center -->
+<g id="edge303" class="edge">
+<title>pep_c&#45;&gt;e_82_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1063.97,-699.49C1044.15,-744.56 990.06,-867.6 980.09,-890.27"/>
+</g>
+<!-- oaa_c -->
+<g id="node45" class="node">
+<title>oaa_c</title>
+<ellipse fill="none" stroke="black" cx="952.47" cy="-986.88" rx="18" ry="18"/>
+<text text-anchor="middle" x="952.47" y="-983.18" font-family="Times,serif" font-size="14.00">oaa_c</text>
+</g>
+<!-- oaa_c&#45;&gt;e_12_center -->
+<g id="edge63" class="edge">
+<title>oaa_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M955.54,-968.78C959.04,-948.73 965.14,-915.5 971.8,-887.19 976.8,-865.94 984.29,-840.86 987.13,-831.54"/>
+</g>
+<!-- oaa_c&#45;&gt;e_14_center -->
+<g id="edge77" class="edge">
+<title>oaa_c&#45;&gt;e_14_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M937.13,-996.51C904.04,-1017.27 827.56,-1065.26 810.09,-1076.22"/>
+</g>
+<!-- oaa_c&#45;&gt;e_79_center -->
+<g id="edge287" class="edge">
+<title>oaa_c&#45;&gt;e_79_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M955.05,-969.04C961.25,-926.04 976.76,-818.66 979.84,-797.29"/>
+</g>
+<!-- nadph_c -->
+<g id="node46" class="node">
+<title>nadph_c</title>
+<ellipse fill="none" stroke="black" cx="1130.02" cy="-921.3" rx="18" ry="18"/>
+<text text-anchor="middle" x="1130.02" y="-917.6" font-family="Times,serif" font-size="14.00">nadph_c</text>
+</g>
+<!-- nadph_c&#45;&gt;e_12_center -->
+<g id="edge65" class="edge">
+<title>nadph_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M1112.58,-915.6C1103.52,-912.34 1092.42,-907.88 1083.05,-902.71 1043.76,-881.02 1003.93,-843.26 991.92,-831.45"/>
+</g>
+<!-- nadph_c&#45;&gt;e_54_center -->
+<g id="edge188" class="edge">
+<title>nadph_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1112.05,-924.74C1069.92,-932.81 966.75,-952.57 946.23,-956.5"/>
+</g>
+<!-- nadph_c&#45;&gt;e_67_center -->
+<g id="edge246" class="edge">
+<title>nadph_c&#45;&gt;e_67_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1147.67,-924.84C1186.07,-932.54 1275.28,-950.44 1294.34,-954.26"/>
+</g>
+<!-- glu__L_c -->
+<g id="node47" class="node">
+<title>glu__L_c</title>
+<ellipse fill="none" stroke="black" cx="761.8" cy="-1000.87" rx="18" ry="18"/>
+<text text-anchor="middle" x="761.8" y="-997.17" font-family="Times,serif" font-size="14.00">glu__L_c</text>
+</g>
+<!-- glu__L_c&#45;&gt;e_12_center -->
+<g id="edge66" class="edge">
+<title>glu__L_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M776.14,-989.3C797.27,-972.29 838.1,-939.64 873.44,-912.64 916.76,-879.53 970.43,-840.68 984.67,-830.41"/>
+</g>
+<!-- glu__L_c&#45;&gt;e_50_center -->
+<g id="edge162" class="edge">
+<title>glu__L_c&#45;&gt;e_50_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.4" d="M747.22,-989.57C740.24,-983.83 731.99,-976.51 725.38,-969.14 718.81,-961.81 712.58,-951.99 709.46,-946.81"/>
+</g>
+<!-- glu__L_c&#45;&gt;e_52_center -->
+<g id="edge176" class="edge">
+<title>glu__L_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.82" d="M776.79,-990.55C804.4,-971.52 861.84,-931.94 876.61,-921.77"/>
+</g>
+<!-- nadp_c -->
+<g id="node48" class="node">
+<title>nadp_c</title>
+<ellipse fill="none" stroke="black" cx="1128.57" cy="-877.28" rx="18" ry="18"/>
+<text text-anchor="middle" x="1128.57" y="-873.58" font-family="Times,serif" font-size="14.00">nadp_c</text>
+</g>
+<!-- nadp_c&#45;&gt;e_47_center -->
+<g id="edge145" class="edge">
+<title>nadp_c&#45;&gt;e_47_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1144.72,-885.8C1162.88,-895.38 1191.14,-910.29 1201.09,-915.54"/>
+</g>
+<!-- nadp_c&#45;&gt;e_52_center -->
+<g id="edge175" class="edge">
+<title>nadp_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.82" d="M1110.71,-880.31C1058.64,-889.12 909.11,-914.43 883.8,-918.72"/>
+</g>
+<!-- e_56_center -->
+<g id="node123" class="node">
+<title>e_56_center</title>
+<polygon fill="none" stroke="black" points="1270.63,-674.19 1263.63,-674.19 1263.63,-667.19 1270.63,-667.19 1270.63,-674.19"/>
+</g>
+<!-- nadp_c&#45;&gt;e_56_center -->
+<g id="edge196" class="edge">
+<title>nadp_c&#45;&gt;e_56_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1138.76,-862.09C1167.76,-818.85 1249.63,-696.79 1264.72,-674.28"/>
+</g>
+<!-- nadp_c&#45;&gt;e_58_center -->
+<g id="edge202" class="edge">
+<title>nadp_c&#45;&gt;e_58_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M1114.26,-888.77C1108.72,-893.17 1102.32,-898.21 1096.45,-902.71 1053.99,-935.28 1001.44,-973.59 987.5,-983.72"/>
+</g>
+<!-- e_65_center -->
+<g id="node132" class="node">
+<title>e_65_center</title>
+<polygon fill="none" stroke="black" points="1260.89,-1014.85 1253.89,-1014.85 1253.89,-1007.85 1260.89,-1007.85 1260.89,-1014.85"/>
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+<!-- nadp_c&#45;&gt;e_65_center -->
+<g id="edge234" class="edge">
+<title>nadp_c&#45;&gt;e_65_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1141.4,-890.63C1169.91,-920.3 1237.33,-990.48 1253.74,-1007.56"/>
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+<!-- nadp_c&#45;&gt;e_91_center -->
+<g id="edge335" class="edge">
+<title>nadp_c&#45;&gt;e_91_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1120.3,-893.49C1116.58,-901.58 1112.56,-911.63 1110.42,-921.11 1093.59,-995.72 1092.58,-1017.04 1101.65,-1092.99 1103.69,-1110.11 1111.06,-1129.48 1114.4,-1137.63"/>
+</g>
+<!-- e_12_center&#45;&gt;coa_c -->
+<g id="edge67" class="edge">
+<title>e_12_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M988.24,-831.43C988.1,-853.22 988.11,-969.33 1003.27,-1062.35 1004.16,-1067.79 1005.43,-1073.53 1006.81,-1079.01"/>
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+</g>
+<!-- e_12_center&#45;&gt;h_c -->
+<g id="edge73" class="edge">
+<title>e_12_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M988.36,-831.57C988.72,-848.63 990.21,-920.56 990.68,-979.58 991.18,-1043.26 986.35,-1117.88 983.36,-1157.56"/>
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+</g>
+<!-- e_12_center&#45;&gt;nadh_c -->
+<g id="edge69" class="edge">
+<title>e_12_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M991.06,-831.57C1008.94,-855.69 1108.25,-989.65 1148.46,-1043.89"/>
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+</g>
+<!-- e_12_center&#45;&gt;adp_c -->
+<g id="edge71" class="edge">
+<title>e_12_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M984.69,-829.93C974.74,-835.77 945.93,-852.61 921.67,-866.04 889.4,-883.91 851.81,-903.83 827.59,-916.56"/>
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+</g>
+<!-- e_12_center&#45;&gt;akg_c -->
+<g id="edge68" class="edge">
+<title>e_12_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M989.55,-831.58C997.52,-855.22 1040.89,-983.8 1060.08,-1040.69"/>
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+</g>
+<!-- e_12_center&#45;&gt;pi_c -->
+<g id="edge70" class="edge">
+<title>e_12_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M984.71,-831.33C967.21,-848.62 889.67,-925.18 852.17,-962.21"/>
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+<!-- e_12_center&#45;&gt;nadp_c -->
+<g id="edge72" class="edge">
+<title>e_12_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M992.2,-828.94C999.61,-831.07 1016.15,-835.93 1029.89,-840.59 1054.51,-848.93 1082.23,-859.33 1102.01,-866.92"/>
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+<!-- co2_e -->
+<g id="node50" class="node">
+<title>co2_e</title>
+<ellipse fill="none" stroke="black" cx="1628.62" cy="-713.55" rx="18" ry="18"/>
+<text text-anchor="middle" x="1628.62" y="-709.85" font-family="Times,serif" font-size="14.00">co2_e</text>
+</g>
+<!-- co2_e&#45;&gt;co2_c -->
+<g id="edge74" class="edge">
+<title>co2_e&#45;&gt;co2_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.4" d="M1611.7,-720.42C1552.75,-744.38 1356.06,-824.29 1284.06,-853.55"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.4" points="1282.32,-850.48 1274.37,-857.48 1284.96,-856.96 1282.32,-850.48"/>
+</g>
+<!-- e_22_target -->
+<g id="node66" class="node">
+<title>e_22_target</title>
+<ellipse fill="black" stroke="black" cx="1877.52" cy="-612.17" rx="1.8" ry="1.8"/>
+</g>
+<!-- co2_e&#45;&gt;e_22_target -->
+<g id="edge101" class="edge">
+<title>co2_e&#45;&gt;e_22_target</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.9" d="M1645.34,-706.74C1692.55,-687.51 1826.04,-633.14 1866.05,-616.84"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.9" points="1867.89,-620.73 1875.53,-612.98 1864.65,-612.78 1867.89,-620.73"/>
+</g>
+<!-- e_14_center&#45;&gt;coa_c -->
+<g id="edge79" class="edge">
+<title>e_14_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M810.11,-1078.96C830.91,-1081.76 936.09,-1095.91 987.13,-1102.77"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.26" points="986.77,-1106.25 997.15,-1104.12 987.71,-1099.31 986.77,-1106.25"/>
+</g>
+<!-- e_14_center&#45;&gt;h_c -->
+<g id="edge80" class="edge">
+<title>e_14_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M810.06,-1080.6C818.15,-1085.43 838.49,-1097.58 855.41,-1107.91 890.92,-1129.59 931.84,-1155.02 957.08,-1170.76"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.26" points="955.3,-1173.78 965.63,-1176.1 959,-1167.84 955.3,-1173.78"/>
+</g>
+<!-- e_14_center&#45;&gt;cit_c -->
+<g id="edge78" class="edge">
+<title>e_14_center&#45;&gt;cit_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M802.61,-1077.85C774.19,-1073.27 597.53,-1044.8 527.68,-1033.54"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.26" points="527.85,-1030.03 517.42,-1031.89 526.74,-1036.94 527.85,-1030.03"/>
+</g>
+<!-- q8h2_c -->
+<g id="node52" class="node">
+<title>q8h2_c</title>
+<ellipse fill="none" stroke="black" cx="812.2" cy="-1566.75" rx="18" ry="18"/>
+<text text-anchor="middle" x="812.2" y="-1563.05" font-family="Times,serif" font-size="14.00">q8h2_c</text>
+</g>
+<!-- q8h2_c&#45;&gt;e_15_center -->
+<g id="edge81" class="edge">
+<title>q8h2_c&#45;&gt;e_15_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M805.59,-1549.74C789.95,-1509.46 751.37,-1410.13 743.41,-1389.63"/>
+</g>
+<!-- e_43_center -->
+<g id="node104" class="node">
+<title>e_43_center</title>
+<polygon fill="none" stroke="black" points="707.93,-1708.25 700.93,-1708.25 700.93,-1701.25 707.93,-1701.25 707.93,-1708.25"/>
+</g>
+<!-- q8h2_c&#45;&gt;e_43_center -->
+<g id="edge130" class="edge">
+<title>q8h2_c&#45;&gt;e_43_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M796.86,-1576.17C787.24,-1582.58 775.01,-1591.69 766.01,-1601.73 735.42,-1635.87 711.93,-1687.41 705.93,-1701.23"/>
+</g>
+<!-- o2_c -->
+<g id="node53" class="node">
+<title>o2_c</title>
+<ellipse fill="none" stroke="black" cx="496.9" cy="-1726.81" rx="18" ry="18"/>
+<text text-anchor="middle" x="496.9" y="-1723.11" font-family="Times,serif" font-size="14.00">o2_c</text>
+</g>
+<!-- o2_c&#45;&gt;e_15_center -->
+<g id="edge83" class="edge">
+<title>o2_c&#45;&gt;e_15_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M507.43,-1712.16C551.04,-1651.49 716.27,-1421.63 739.29,-1389.6"/>
+</g>
+<!-- q8_c -->
+<g id="node54" class="node">
+<title>q8_c</title>
+<ellipse fill="none" stroke="black" cx="763.56" cy="-1560.62" rx="18" ry="18"/>
+<text text-anchor="middle" x="763.56" y="-1556.92" font-family="Times,serif" font-size="14.00">q8_c</text>
+</g>
+<!-- q8_c&#45;&gt;e_66_center -->
+<g id="edge239" class="edge">
+<title>q8_c&#45;&gt;e_66_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M776.05,-1547.62C817.15,-1504.84 946.85,-1369.83 969.82,-1345.92"/>
+</g>
+<!-- e_88_center -->
+<g id="node150" class="node">
+<title>e_88_center</title>
+<polygon fill="none" stroke="black" points="668.49,-1684.22 661.49,-1684.22 661.49,-1677.22 668.49,-1677.22 668.49,-1684.22"/>
+</g>
+<!-- q8_c&#45;&gt;e_88_center -->
+<g id="edge321" class="edge">
+<title>q8_c&#45;&gt;e_88_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M751.86,-1574.87C729.22,-1602.46 680.52,-1661.8 667.98,-1677.08"/>
+</g>
+<!-- e_15_center&#45;&gt;h2o_c -->
+<g id="edge84" class="edge">
+<title>e_15_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M742.13,-1382.16C742.61,-1371.82 743.93,-1341.92 744.37,-1317.05 744.47,-1311.09 744.41,-1309.6 744.37,-1303.65 743.51,-1184.68 741.02,-1042.88 739.91,-983.61"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="744.28,-983.45 739.72,-973.53 735.53,-983.61 744.28,-983.45"/>
+</g>
+<!-- e_15_center&#45;&gt;h_e -->
+<g id="edge86" class="edge">
+<title>e_15_center&#45;&gt;h_e</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M745.48,-1385.93C768.96,-1386.21 903.51,-1387.83 963.11,-1388.54"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="963.27,-1392.92 973.32,-1388.67 963.37,-1384.17 963.27,-1392.92"/>
+</g>
+<!-- e_15_center&#45;&gt;q8_c -->
+<g id="edge85" class="edge">
+<title>e_15_center&#45;&gt;q8_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M742.41,-1389.54C744.65,-1407.69 754.72,-1489.14 760.11,-1532.79"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="755.78,-1533.37 761.35,-1542.76 764.46,-1532.3 755.78,-1533.37"/>
+</g>
+<!-- lac__D_e -->
+<g id="node56" class="node">
+<title>lac__D_e</title>
+<ellipse fill="none" stroke="black" cx="1432.18" cy="-1785.04" rx="18" ry="18"/>
+<text text-anchor="middle" x="1432.18" y="-1781.34" font-family="Times,serif" font-size="14.00">lac__D_e</text>
+</g>
+<!-- lac__D_e&#45;&gt;e_16_center -->
+<g id="edge88" class="edge">
+<title>lac__D_e&#45;&gt;e_16_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1421.43,-1770.34C1381.79,-1716.15 1245.06,-1529.21 1223.94,-1500.34"/>
+</g>
+<!-- e_32_target -->
+<g id="node83" class="node">
+<title>e_32_target</title>
+<ellipse fill="black" stroke="black" cx="1591.94" cy="-2000.26" rx="1.8" ry="1.8"/>
+</g>
+<!-- lac__D_e&#45;&gt;e_32_target -->
+<g id="edge111" class="edge">
+<title>lac__D_e&#45;&gt;e_32_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1442.91,-1799.5C1473.21,-1840.32 1558.9,-1955.75 1584.58,-1990.34"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1581.89,-1992.59 1590.66,-1998.54 1587.51,-1988.42 1581.89,-1992.59"/>
+</g>
+<!-- lac__D_c -->
+<g id="node57" class="node">
+<title>lac__D_c</title>
+<ellipse fill="none" stroke="black" cx="1392.51" cy="-1386.26" rx="18" ry="18"/>
+<text text-anchor="middle" x="1392.51" y="-1382.56" font-family="Times,serif" font-size="14.00">lac__D_c</text>
+</g>
+<!-- lac__D_c&#45;&gt;e_60_center -->
+<g id="edge209" class="edge">
+<title>lac__D_c&#45;&gt;e_60_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1382.32,-1370.76C1362.29,-1340.12 1316.64,-1269.44 1281.18,-1208.27 1271.49,-1191.56 1260.9,-1171.03 1256.74,-1162.85"/>
+</g>
+<!-- e_16_center&#45;&gt;h_c -->
+<g id="edge90" class="edge">
+<title>e_16_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1218.76,-1492.92C1203.38,-1469.83 1117.61,-1342.21 1037.66,-1245.97 1026.19,-1232.16 1012.41,-1217.47 1001.32,-1206.05"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1003.64,-1203.41 994.14,-1198.72 998.64,-1208.31 1003.64,-1203.41"/>
+</g>
+<!-- e_16_center&#45;&gt;lac__D_c -->
+<g id="edge89" class="edge">
+<title>e_16_center&#45;&gt;lac__D_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1224.76,-1494.27C1243.07,-1482.48 1327.04,-1428.42 1368.79,-1401.53"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1370.75,-1404.43 1377.26,-1396.08 1366.96,-1398.55 1370.75,-1404.43"/>
+</g>
+<!-- 2pg_c -->
+<g id="node59" class="node">
+<title>2pg_c</title>
+<ellipse fill="none" stroke="black" cx="684.29" cy="-395.02" rx="18" ry="18"/>
+<text text-anchor="middle" x="684.29" y="-391.32" font-family="Times,serif" font-size="14.00">2pg_c</text>
+</g>
+<!-- 2pg_c&#45;&gt;3pg_c -->
+<g id="edge275" class="edge">
+<title>2pg_c&#45;&gt;3pg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.06" d="M695.71,-409.1C718.59,-437.31 770.21,-500.96 797.63,-534.77"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.06" points="795.03,-537.12 804.05,-542.68 800.47,-532.71 795.03,-537.12"/>
+</g>
+<!-- e_17_center -->
+<g id="node60" class="node">
+<title>e_17_center</title>
+<polygon fill="none" stroke="black" points="791.89,-629.89 784.89,-629.89 784.89,-622.89 791.89,-622.89 791.89,-629.89"/>
+</g>
+<!-- 2pg_c&#45;&gt;e_17_center -->
+<g id="edge91" class="edge">
+<title>2pg_c&#45;&gt;e_17_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.06" d="M691.78,-411.66C713.5,-459.94 775.72,-598.21 786.72,-622.67"/>
+</g>
+<!-- e_17_center&#45;&gt;h2o_c -->
+<g id="edge92" class="edge">
+<title>e_17_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.06" d="M788.43,-630.03C788.57,-650.15 788.21,-749.64 768.44,-827.52 761.87,-853.4 751.13,-856.83 744.87,-882.78 741.41,-897.14 739.96,-913.51 739.41,-927.07"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.06" points="735.9,-927.16 739.13,-937.25 742.9,-927.34 735.9,-927.16"/>
+</g>
+<!-- e_17_center&#45;&gt;pep_c -->
+<g id="edge93" class="edge">
+<title>e_17_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.06" d="M791.97,-627.1C817.9,-632.29 977.88,-664.27 1043.35,-677.36"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.06" points="1042.88,-680.83 1053.37,-679.36 1044.25,-673.97 1042.88,-680.83"/>
+</g>
+<!-- etoh_e -->
+<g id="node61" class="node">
+<title>etoh_e</title>
+<ellipse fill="none" stroke="black" cx="1316.34" cy="-1870.45" rx="18" ry="18"/>
+<text text-anchor="middle" x="1316.34" y="-1866.75" font-family="Times,serif" font-size="14.00">etoh_e</text>
+</g>
+<!-- etoh_e&#45;&gt;e_18_center -->
+<g id="edge95" class="edge">
+<title>etoh_e&#45;&gt;e_18_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1308.85,-1853.94C1281.12,-1792.84 1185.17,-1581.44 1171.08,-1550.4"/>
+</g>
+<!-- e_23_target -->
+<g id="node67" class="node">
+<title>e_23_target</title>
+<ellipse fill="black" stroke="black" cx="1426.8" cy="-2112.26" rx="1.8" ry="1.8"/>
+</g>
+<!-- etoh_e&#45;&gt;e_23_target -->
+<g id="edge102" class="edge">
+<title>etoh_e&#45;&gt;e_23_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1323.93,-1887.07C1345.04,-1933.28 1404.05,-2062.46 1421.73,-2101.16"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1418.58,-2102.69 1425.92,-2110.33 1424.95,-2099.78 1418.58,-2102.69"/>
+</g>
+<!-- e_18_center&#45;&gt;h_c -->
+<g id="edge96" class="edge">
+<title>e_18_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1166.89,-1542.84C1151.44,-1519.2 1066.34,-1387.75 1009.87,-1273.62 1000.29,-1254.26 992.82,-1230.97 987.9,-1213.23"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="991.26,-1212.26 985.29,-1203.5 984.5,-1214.07 991.26,-1212.26"/>
+</g>
+<!-- e_18_center&#45;&gt;etoh_c -->
+<g id="edge97" class="edge">
+<title>e_18_center&#45;&gt;etoh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1173.13,-1546.13C1193.45,-1543.69 1290.46,-1532.06 1339.38,-1526.19"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1340.09,-1529.63 1349.6,-1524.96 1339.25,-1522.68 1340.09,-1529.63"/>
+</g>
+<!-- e_24_target -->
+<g id="node68" class="node">
+<title>e_24_target</title>
+<ellipse fill="black" stroke="black" cx="1806.83" cy="-1672.53" rx="1.8" ry="1.8"/>
+</g>
+<!-- for_e -->
+<g id="node69" class="node">
+<title>for_e</title>
+<ellipse fill="none" stroke="black" cx="1583.93" cy="-1537.52" rx="18" ry="18"/>
+<text text-anchor="middle" x="1583.93" y="-1533.82" font-family="Times,serif" font-size="14.00">for_e</text>
+</g>
+<!-- for_e&#45;&gt;e_24_target -->
+<g id="edge103" class="edge">
+<title>for_e&#45;&gt;e_24_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1599.6,-1547.02C1642.34,-1572.9 1760.1,-1644.22 1796.19,-1666.08"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1794.7,-1669.27 1805.07,-1671.45 1798.32,-1663.28 1794.7,-1669.27"/>
+</g>
+<!-- for_e&#45;&gt;e_41_center -->
+<g id="edge125" class="edge">
+<title>for_e&#45;&gt;e_41_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1567.28,-1530.36C1507.73,-1504.76 1307.29,-1418.57 1277.86,-1405.92"/>
+</g>
+<!-- e_25_target -->
+<g id="node70" class="node">
+<title>e_25_target</title>
+<ellipse fill="black" stroke="black" cx="1605.33" cy="-1.81" rx="1.8" ry="1.8"/>
+</g>
+<!-- fru_e -->
+<g id="node71" class="node">
+<title>fru_e</title>
+<ellipse fill="none" stroke="black" cx="1470.18" cy="-219.74" rx="18" ry="18"/>
+<text text-anchor="middle" x="1470.18" y="-216.04" font-family="Times,serif" font-size="14.00">fru_e</text>
+</g>
+<!-- fru_e&#45;&gt;e_25_target -->
+<g id="edge104" class="edge">
+<title>fru_e&#45;&gt;e_25_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1479.68,-204.42C1505.59,-162.63 1577,-47.5 1598.88,-12.22"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1601.96,-13.88 1604.26,-3.54 1596.02,-10.19 1601.96,-13.88"/>
+</g>
+<!-- fru_e&#45;&gt;e_44_center -->
+<g id="edge134" class="edge">
+<title>fru_e&#45;&gt;e_44_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1460.04,-235.13C1422.52,-292.1 1292.69,-489.2 1273.62,-518.15"/>
+</g>
+<!-- e_26_target -->
+<g id="node72" class="node">
+<title>e_26_target</title>
+<ellipse fill="black" stroke="black" cx="946.12" cy="-2215.71" rx="1.8" ry="1.8"/>
+</g>
+<!-- fum_e -->
+<g id="node73" class="node">
+<title>fum_e</title>
+<ellipse fill="none" stroke="black" cx="949.94" cy="-1951.54" rx="18" ry="18"/>
+<text text-anchor="middle" x="949.94" y="-1947.84" font-family="Times,serif" font-size="14.00">fum_e</text>
+</g>
+<!-- fum_e&#45;&gt;e_26_target -->
+<g id="edge105" class="edge">
+<title>fum_e&#45;&gt;e_26_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M949.68,-1969.7C948.95,-2020.19 946.91,-2161.31 946.3,-2203.59"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="942.8,-2203.55 946.15,-2213.6 949.8,-2203.65 942.8,-2203.55"/>
+</g>
+<!-- fum_e&#45;&gt;e_46_center -->
+<g id="edge142" class="edge">
+<title>fum_e&#45;&gt;e_46_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M950.19,-1933.28C951.13,-1865.38 954.39,-1629.77 954.84,-1596.97"/>
+</g>
+<!-- e_27_target -->
+<g id="node74" class="node">
+<title>e_27_target</title>
+<ellipse fill="black" stroke="black" cx="1813.63" cy="-190.22" rx="1.8" ry="1.8"/>
+</g>
+<!-- glc__D_e -->
+<g id="node75" class="node">
+<title>glc__D_e</title>
+<ellipse fill="none" stroke="black" cx="1625.01" cy="-356.6" rx="18" ry="18"/>
+<text text-anchor="middle" x="1625.01" y="-352.9" font-family="Times,serif" font-size="14.00">glc__D_e</text>
+</g>
+<!-- glc__D_e&#45;&gt;e_27_target -->
+<g id="edge106" class="edge">
+<title>glc__D_e&#45;&gt;e_27_target</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.3" d="M1638.57,-344.64C1674.84,-312.64 1773.39,-225.71 1804.25,-198.48"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.3" points="1806.95,-200.77 1812.14,-191.53 1802.32,-195.52 1806.95,-200.77"/>
+</g>
+<!-- glc__D_e&#45;&gt;e_49_center -->
+<g id="edge156" class="edge">
+<title>glc__D_e&#45;&gt;e_49_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.3" d="M1611.3,-368.44C1560.77,-412.08 1386.47,-562.6 1359.54,-585.86"/>
+</g>
+<!-- e_28_target -->
+<g id="node76" class="node">
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+<!-- gln__L_e -->
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+</g>
+<!-- gln__L_e&#45;&gt;e_28_target -->
+<g id="edge107" class="edge">
+<title>gln__L_e&#45;&gt;e_28_target</title>
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+<!-- gln__L_e&#45;&gt;e_51_center -->
+<g id="edge168" class="edge">
+<title>gln__L_e&#45;&gt;e_51_center</title>
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+<!-- e_29_target -->
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+<title>e_29_target</title>
+<ellipse fill="black" stroke="black" cx="90.58" cy="-1518.57" rx="1.8" ry="1.8"/>
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+<!-- glu__L_e -->
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+<!-- glu__L_e&#45;&gt;e_29_target -->
+<g id="edge108" class="edge">
+<title>glu__L_e&#45;&gt;e_29_target</title>
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+<!-- glu__L_e&#45;&gt;e_55_center -->
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+<title>glu__L_e&#45;&gt;e_55_center</title>
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+<!-- e_31_target -->
+<g id="node81" class="node">
+<title>e_31_target</title>
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+<!-- h2o_e -->
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+<title>h2o_e</title>
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+</g>
+<!-- h2o_e&#45;&gt;h2o_c -->
+<g id="edge200" class="edge">
+<title>h2o_e&#45;&gt;h2o_c</title>
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+</g>
+<!-- h2o_e&#45;&gt;e_31_target -->
+<g id="edge110" class="edge">
+<title>h2o_e&#45;&gt;e_31_target</title>
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+<!-- e_33_target -->
+<g id="node84" class="node">
+<title>e_33_target</title>
+<ellipse fill="black" stroke="black" cx="1235.71" cy="-2122.97" rx="1.8" ry="1.8"/>
+</g>
+<!-- mal__L_e -->
+<g id="node85" class="node">
+<title>mal__L_e</title>
+<ellipse fill="none" stroke="black" cx="1175.85" cy="-1863.61" rx="18" ry="18"/>
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+</g>
+<!-- mal__L_e&#45;&gt;e_33_target -->
+<g id="edge112" class="edge">
+<title>mal__L_e&#45;&gt;e_33_target</title>
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+<!-- mal__L_e&#45;&gt;e_62_center -->
+<g id="edge221" class="edge">
+<title>mal__L_e&#45;&gt;e_62_center</title>
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+<!-- e_34_target -->
+<g id="node86" class="node">
+<title>e_34_target</title>
+<ellipse fill="black" stroke="black" cx="66.3" cy="-299" rx="1.8" ry="1.8"/>
+</g>
+<!-- nh4_e -->
+<g id="node87" class="node">
+<title>nh4_e</title>
+<ellipse fill="none" stroke="black" cx="258.33" cy="-464.09" rx="18" ry="18"/>
+<text text-anchor="middle" x="258.33" y="-460.39" font-family="Times,serif" font-size="14.00">nh4_e</text>
+</g>
+<!-- nh4_e&#45;&gt;e_34_target -->
+<g id="edge113" class="edge">
+<title>nh4_e&#45;&gt;e_34_target</title>
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+<!-- nh4_c -->
+<g id="node114" class="node">
+<title>nh4_c</title>
+<ellipse fill="none" stroke="black" cx="555.07" cy="-722.65" rx="18" ry="18"/>
+<text text-anchor="middle" x="555.07" y="-718.95" font-family="Times,serif" font-size="14.00">nh4_c</text>
+</g>
+<!-- nh4_e&#45;&gt;nh4_c -->
+<g id="edge249" class="edge">
+<title>nh4_e&#45;&gt;nh4_c</title>
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+<!-- e_35_target -->
+<g id="node88" class="node">
+<title>e_35_target</title>
+<ellipse fill="black" stroke="black" cx="126.79" cy="-2226.11" rx="1.8" ry="1.8"/>
+</g>
+<!-- o2_e -->
+<g id="node89" class="node">
+<title>o2_e</title>
+<ellipse fill="none" stroke="black" cx="273.55" cy="-2032.72" rx="18" ry="18"/>
+<text text-anchor="middle" x="273.55" y="-2029.02" font-family="Times,serif" font-size="14.00">o2_e</text>
+</g>
+<!-- o2_e&#45;&gt;o2_c -->
+<g id="edge250" class="edge">
+<title>o2_e&#45;&gt;o2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.85" d="M284.32,-2017.97C320.29,-1968.7 436.45,-1809.6 480.11,-1749.81"/>
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+<!-- o2_e&#45;&gt;e_35_target -->
+<g id="edge114" class="edge">
+<title>o2_e&#45;&gt;e_35_target</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.4" d="M262.52,-2047.26C233.89,-2084.98 157.83,-2185.22 134.02,-2216.59"/>
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+<!-- e_36_target -->
+<g id="node90" class="node">
+<title>e_36_target</title>
+<ellipse fill="black" stroke="black" cx="200.78" cy="-1664.16" rx="1.8" ry="1.8"/>
+</g>
+<!-- pi_e -->
+<g id="node91" class="node">
+<title>pi_e</title>
+<ellipse fill="none" stroke="black" cx="431.69" cy="-1516.19" rx="18" ry="18"/>
+<text text-anchor="middle" x="431.69" y="-1512.49" font-family="Times,serif" font-size="14.00">pi_e</text>
+</g>
+<!-- pi_e&#45;&gt;e_36_target -->
+<g id="edge115" class="edge">
+<title>pi_e&#45;&gt;e_36_target</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.25" d="M416.18,-1526.13C372.38,-1554.19 248.54,-1633.55 211.42,-1657.34"/>
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+<!-- pi_e&#45;&gt;e_77_center -->
+<g id="edge277" class="edge">
+<title>pi_e&#45;&gt;e_77_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.25" d="M446.86,-1505.98C504.02,-1467.53 704.59,-1332.6 734.04,-1312.78"/>
+</g>
+<!-- e_37_target -->
+<g id="node92" class="node">
+<title>e_37_target</title>
+<ellipse fill="black" stroke="black" cx="1917.12" cy="-1245.63" rx="1.8" ry="1.8"/>
+</g>
+<!-- pyr_e -->
+<g id="node93" class="node">
+<title>pyr_e</title>
+<ellipse fill="none" stroke="black" cx="1657.9" cy="-1228.74" rx="18" ry="18"/>
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+</g>
+<!-- pyr_e&#45;&gt;e_37_target -->
+<g id="edge116" class="edge">
+<title>pyr_e&#45;&gt;e_37_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1676.13,-1229.92C1725.94,-1233.17 1863.37,-1242.12 1905.01,-1244.84"/>
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+<!-- pyr_e&#45;&gt;e_83_center -->
+<g id="edge308" class="edge">
+<title>pyr_e&#45;&gt;e_83_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1639.8,-1227.41C1570.45,-1222.32 1323.86,-1204.21 1291.41,-1201.83"/>
+</g>
+<!-- e_38_target -->
+<g id="node94" class="node">
+<title>e_38_target</title>
+<ellipse fill="black" stroke="black" cx="784.72" cy="-2052.99" rx="1.8" ry="1.8"/>
+</g>
+<!-- succ_e -->
+<g id="node95" class="node">
+<title>succ_e</title>
+<ellipse fill="none" stroke="black" cx="845.07" cy="-1785.55" rx="18" ry="18"/>
+<text text-anchor="middle" x="845.07" y="-1781.85" font-family="Times,serif" font-size="14.00">succ_e</text>
+</g>
+<!-- succ_e&#45;&gt;e_38_target -->
+<g id="edge117" class="edge">
+<title>succ_e&#45;&gt;e_38_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M841.02,-1803.51C829.55,-1854.35 797.06,-1998.29 787.44,-2040.94"/>
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+</g>
+<!-- succ_e&#45;&gt;e_86_center -->
+<g id="edge313" class="edge">
+<title>succ_e&#45;&gt;e_86_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M849.09,-1767.76C861.39,-1713.26 898.09,-1550.66 904.03,-1524.35"/>
+</g>
+<!-- fdp_c -->
+<g id="node96" class="node">
+<title>fdp_c</title>
+<ellipse fill="none" stroke="black" cx="840.62" cy="-486.8" rx="18" ry="18"/>
+<text text-anchor="middle" x="840.62" y="-483.1" font-family="Times,serif" font-size="14.00">fdp_c</text>
+</g>
+<!-- e_39_center -->
+<g id="node98" class="node">
+<title>e_39_center</title>
+<polygon fill="none" stroke="black" points="885.53,-271.53 878.53,-271.53 878.53,-264.53 885.53,-264.53 885.53,-271.53"/>
+</g>
+<!-- fdp_c&#45;&gt;e_39_center -->
+<g id="edge118" class="edge">
+<title>fdp_c&#45;&gt;e_39_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.77" d="M844.01,-468.9C852.97,-421.55 876.91,-295.05 881.32,-271.75"/>
+</g>
+<!-- fdp_c&#45;&gt;e_40_center -->
+<g id="edge122" class="edge">
+<title>fdp_c&#45;&gt;e_40_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M839.94,-505.13C838.17,-552.92 833.5,-679.23 832.64,-702.49"/>
+</g>
+<!-- dhap_c -->
+<g id="node97" class="node">
+<title>dhap_c</title>
+<ellipse fill="none" stroke="black" cx="939.41" cy="-160.01" rx="18" ry="18"/>
+<text text-anchor="middle" x="939.41" y="-156.31" font-family="Times,serif" font-size="14.00">dhap_c</text>
+</g>
+<!-- dhap_c&#45;&gt;g3p_c -->
+<g id="edge349" class="edge">
+<title>dhap_c&#45;&gt;g3p_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.77" d="M943.33,-177.86C954.38,-228.14 985.83,-371.25 999.17,-431.95"/>
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+<!-- e_39_center&#45;&gt;g3p_c -->
+<g id="edge120" class="edge">
+<title>e_39_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.77" d="M884.38,-271.69C897.32,-291.83 960.4,-389.93 989.94,-435.88"/>
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+<!-- e_39_center&#45;&gt;dhap_c -->
+<g id="edge119" class="edge">
+<title>e_39_center&#45;&gt;dhap_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.77" d="M883.94,-264.44C890.41,-252.25 911.9,-211.8 926.15,-184.96"/>
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+<!-- e_40_center&#45;&gt;pi_c -->
+<g id="edge123" class="edge">
+<title>e_40_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M832.49,-710.11C832.42,-736.51 831.99,-889.82 831.81,-954.07"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="828.31,-954.28 831.79,-964.29 835.31,-954.3 828.31,-954.28"/>
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+<!-- e_40_center&#45;&gt;f6p_c -->
+<g id="edge124" class="edge">
+<title>e_40_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M836.07,-703.43C857.31,-686.91 967.68,-601.02 1015.74,-563.63"/>
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+<!-- for_c -->
+<g id="node100" class="node">
+<title>for_c</title>
+<ellipse fill="none" stroke="black" cx="1470.76" cy="-1343.74" rx="18" ry="18"/>
+<text text-anchor="middle" x="1470.76" y="-1340.04" font-family="Times,serif" font-size="14.00">for_c</text>
+</g>
+<!-- for_c&#45;&gt;for_e -->
+<g id="edge129" class="edge">
+<title>for_c&#45;&gt;for_e</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1480.02,-1359.6C1499.76,-1393.39 1546.07,-1472.71 1569.63,-1513.04"/>
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+<!-- e_41_center&#45;&gt;h_c -->
+<g id="edge128" class="edge">
+<title>e_41_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1270.54,-1401.6C1242.81,-1380.93 1067.16,-1249.94 1003.81,-1202.71"/>
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+<!-- e_41_center&#45;&gt;for_c -->
+<g id="edge127" class="edge">
+<title>e_41_center&#45;&gt;for_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1277.92,-1403.16C1292.44,-1398.41 1347.27,-1380.54 1392.67,-1366.66 1409.57,-1361.49 1428.61,-1355.9 1443.65,-1351.53"/>
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+<!-- fum_c -->
+<g id="node102" class="node">
+<title>fum_c</title>
+<ellipse fill="none" stroke="black" cx="779.73" cy="-1615.73" rx="18" ry="18"/>
+<text text-anchor="middle" x="779.73" y="-1612.03" font-family="Times,serif" font-size="14.00">fum_c</text>
+</g>
+<!-- fum_c&#45;&gt;e_43_center -->
+<g id="edge131" class="edge">
+<title>fum_c&#45;&gt;e_43_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M767.97,-1629.64C750.26,-1650.57 717.76,-1688.99 707.57,-1701.04"/>
+</g>
+<!-- fum_c&#45;&gt;e_45_center -->
+<g id="edge139" class="edge">
+<title>fum_c&#45;&gt;e_45_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M782.81,-1597.81C793.3,-1536.88 827.2,-1339.81 832.18,-1310.89"/>
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+<!-- succ_c -->
+<g id="node103" class="node">
+<title>succ_c</title>
+<ellipse fill="none" stroke="black" cx="706.39" cy="-1491.69" rx="18" ry="18"/>
+<text text-anchor="middle" x="706.39" y="-1487.99" font-family="Times,serif" font-size="14.00">succ_c</text>
+</g>
+<!-- succ_c&#45;&gt;e_87_center -->
+<g id="edge318" class="edge">
+<title>succ_c&#45;&gt;e_87_center</title>
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+<!-- succ_c&#45;&gt;e_88_center -->
+<g id="edge322" class="edge">
+<title>succ_c&#45;&gt;e_88_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M702.5,-1509.47C693.24,-1551.75 670.34,-1656.29 665.78,-1677.09"/>
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+<!-- succ_c&#45;&gt;e_89_center -->
+<g id="edge327" class="edge">
+<title>succ_c&#45;&gt;e_89_center</title>
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+<!-- e_43_center&#45;&gt;q8_c -->
+<g id="edge132" class="edge">
+<title>e_43_center&#45;&gt;q8_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M705.89,-1701.19C712.27,-1685.65 737.96,-1623.02 752.81,-1586.82"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="756.13,-1587.95 756.69,-1577.37 749.65,-1585.29 756.13,-1587.95"/>
+</g>
+<!-- e_43_center&#45;&gt;succ_c -->
+<g id="edge133" class="edge">
+<title>e_43_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M704.47,-1701.05C704.66,-1679.8 705.65,-1572.31 706.13,-1520.16"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="709.63,-1519.95 706.23,-1509.92 702.63,-1519.89 709.63,-1519.95"/>
+</g>
+<!-- e_44_center&#45;&gt;f6p_c -->
+<g id="edge137" class="edge">
+<title>e_44_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1267.62,-522.09C1244.87,-524.48 1122.02,-537.38 1066.01,-543.27"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1065.63,-539.79 1056.05,-544.31 1066.36,-546.75 1065.63,-539.79"/>
+</g>
+<!-- e_44_center&#45;&gt;pyr_c -->
+<g id="edge136" class="edge">
+<title>e_44_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1270.65,-525.24C1265.27,-555.55 1226.75,-772.43 1212.84,-850.77"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1209.35,-850.42 1211.04,-860.87 1216.24,-851.64 1209.35,-850.42"/>
+</g>
+<!-- mal__L_c -->
+<g id="node106" class="node">
+<title>mal__L_c</title>
+<ellipse fill="none" stroke="black" cx="1099.9" cy="-1247.54" rx="18" ry="18"/>
+<text text-anchor="middle" x="1099.9" y="-1243.84" font-family="Times,serif" font-size="14.00">mal__L_c</text>
+</g>
+<!-- mal__L_c&#45;&gt;e_63_center -->
+<g id="edge225" class="edge">
+<title>mal__L_c&#45;&gt;e_63_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1094.2,-1230.31C1088.25,-1212.28 1079.32,-1185.24 1076.06,-1175.37"/>
+</g>
+<!-- mal__L_c&#45;&gt;e_64_center -->
+<g id="edge230" class="edge">
+<title>mal__L_c&#45;&gt;e_64_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1112.62,-1234.51C1150.95,-1195.26 1264.01,-1079.51 1285.73,-1057.27"/>
+</g>
+<!-- mal__L_c&#45;&gt;e_65_center -->
+<g id="edge235" class="edge">
+<title>mal__L_c&#45;&gt;e_65_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1108.7,-1231.55C1124.77,-1202.72 1160.38,-1140.39 1194.83,-1090.68 1216.01,-1060.11 1245.01,-1025.77 1254.36,-1014.87"/>
+</g>
+<!-- e_45_center&#45;&gt;mal__L_c -->
+<g id="edge140" class="edge">
+<title>e_45_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M836.5,-1307.13C856.16,-1305.98 950.06,-1299.6 1023.72,-1279.4 1030.15,-1277.63 1031.44,-1276.25 1037.59,-1273.69 1049.57,-1268.71 1062.83,-1263.16 1074.03,-1258.45"/>
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+</g>
+<!-- e_46_center&#45;&gt;h_c -->
+<g id="edge143" class="edge">
+<title>e_46_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M954.99,-1589.53C955.61,-1566.56 959.27,-1439.18 966.62,-1335.58 969.63,-1293.09 974.67,-1243.98 977.93,-1213.89"/>
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+</g>
+<!-- e_46_center&#45;&gt;fum_c -->
+<g id="edge144" class="edge">
+<title>e_46_center&#45;&gt;fum_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M951.24,-1593.64C933.04,-1595.98 851.39,-1606.5 807.64,-1612.13"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="807.11,-1608.67 797.64,-1613.42 808.01,-1615.61 807.11,-1608.67"/>
+</g>
+<!-- 6pgl_c -->
+<g id="node109" class="node">
+<title>6pgl_c</title>
+<ellipse fill="none" stroke="black" cx="1349.81" cy="-807.12" rx="18" ry="18"/>
+<text text-anchor="middle" x="1349.81" y="-803.42" font-family="Times,serif" font-size="14.00">6pgl_c</text>
+</g>
+<!-- 6pgl_c&#45;&gt;e_75_center -->
+<g id="edge272" class="edge">
+<title>6pgl_c&#45;&gt;e_75_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1332.2,-812.74C1302.98,-822.26 1242.89,-842.71 1194.07,-864.96 1170.64,-875.65 1165.81,-880.45 1142.39,-891.18 1136.33,-893.96 1135.07,-895.66 1128.52,-896.88 1115.81,-899.24 1100.36,-897.57 1093.43,-896.59"/>
+</g>
+<!-- e_47_center&#45;&gt;h_c -->
+<g id="edge148" class="edge">
+<title>e_47_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1202.24,-921.18C1190.06,-939.4 1135.06,-1020.72 1082.98,-1081.74 1056.64,-1112.6 1023.27,-1145.65 1002.04,-1166.01"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.75" points="998.91,-1163.26 994.54,-1173.16 1004.64,-1169.27 998.91,-1163.26"/>
+</g>
+<!-- e_47_center&#45;&gt;nadph_c -->
+<g id="edge149" class="edge">
+<title>e_47_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1201.11,-917.64C1193.41,-918.04 1174.74,-919 1158.46,-919.83"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.75" points="1158.02,-915.7 1148.24,-920.36 1158.45,-924 1158.02,-915.7"/>
+</g>
+<!-- e_47_center&#45;&gt;6pgl_c -->
+<g id="edge147" class="edge">
+<title>e_47_center&#45;&gt;6pgl_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1208.48,-915.58C1218.88,-910.35 1248.7,-894.83 1271.13,-878.34 1292.37,-862.73 1314.44,-842.32 1329.78,-827.36"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.75" points="1332.96,-830.07 1337.15,-820.08 1327.12,-824.15 1332.96,-830.07"/>
+</g>
+<!-- 13dpg_c -->
+<g id="node111" class="node">
+<title>13dpg_c</title>
+<ellipse fill="none" stroke="black" cx="904.29" cy="-601.16" rx="18" ry="18"/>
+<text text-anchor="middle" x="904.29" y="-597.46" font-family="Times,serif" font-size="14.00">13dpg_c</text>
+</g>
+<!-- e_48_center&#45;&gt;h_c -->
+<g id="edge154" class="edge">
+<title>e_48_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.27" d="M1022.72,-851.09C1018.97,-881.2 993.98,-1082 984.61,-1157.3"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.27" points="981.11,-1157.11 983.34,-1167.46 988.05,-1157.97 981.11,-1157.11"/>
+</g>
+<!-- e_48_center&#45;&gt;nadh_c -->
+<g id="edge153" class="edge">
+<title>e_48_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.27" d="M1025.66,-851.09C1040.34,-873.75 1116.66,-991.52 1149.89,-1042.8"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.27" points="1147.01,-1044.8 1155.38,-1051.29 1152.88,-1040.99 1147.01,-1044.8"/>
+</g>
+<!-- e_48_center&#45;&gt;13dpg_c -->
+<g id="edge155" class="edge">
+<title>e_48_center&#45;&gt;13dpg_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.27" d="M1021.32,-843.42C1009.45,-818.85 944.15,-683.67 916.58,-626.6"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.27" points="919.69,-625 912.19,-617.52 913.39,-628.05 919.69,-625"/>
+</g>
+<!-- e_49_center&#45;&gt;pyr_c -->
+<g id="edge158" class="edge">
+<title>e_49_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.3" d="M1354.16,-592.55C1340.36,-619.56 1254.08,-788.41 1220.86,-853.43"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.3" points="1217.61,-852.09 1216.18,-862.59 1223.85,-855.28 1217.61,-852.09"/>
+</g>
+<!-- e_49_center&#45;&gt;g6p_c -->
+<g id="edge159" class="edge">
+<title>e_49_center&#45;&gt;g6p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.3" d="M1352.39,-590.75C1335.12,-599.56 1260.82,-637.5 1221.06,-657.8"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.3" points="1219.29,-654.77 1211.98,-662.44 1222.48,-661.01 1219.29,-654.77"/>
+</g>
+<!-- nh4_c&#45;&gt;e_50_center -->
+<g id="edge161" class="edge">
+<title>nh4_c&#45;&gt;e_50_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.4" d="M565.3,-737.47C596.38,-782.49 688.59,-916.04 704.9,-939.67"/>
+</g>
+<!-- e_50_center&#45;&gt;h_c -->
+<g id="edge165" class="edge">
+<title>e_50_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.4" d="M709.18,-947.11C711.95,-952.66 717.74,-962.93 725.38,-969.14 743.8,-984.1 755.85,-974 775.68,-987.03 854.84,-1039.06 930.16,-1124.01 963.34,-1163.84"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.4" points="960.71,-1166.14 969.77,-1171.63 966.11,-1161.69 960.71,-1166.14"/>
+</g>
+<!-- e_50_center&#45;&gt;adp_c -->
+<g id="edge164" class="edge">
+<title>e_50_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.4" d="M711.11,-942.23C717.07,-940.62 729.13,-937.51 739.54,-935.81 750.82,-933.96 763.34,-932.61 774.22,-931.65"/>
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+</g>
+<!-- e_50_center&#45;&gt;pi_c -->
+<g id="edge163" class="edge">
+<title>e_50_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.4" d="M711.09,-941.61C717.02,-939.15 729.03,-934.89 739.54,-935.81 765.25,-938.04 791.19,-952.49 808.98,-964.7"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.4" points="807.32,-967.83 817.49,-970.81 811.41,-962.14 807.32,-967.83"/>
+</g>
+<!-- e_50_center&#45;&gt;gln__L_c -->
+<g id="edge166" class="edge">
+<title>e_50_center&#45;&gt;gln__L_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.4" d="M708.67,-939.67C713.24,-926.89 728.99,-882.89 739.36,-853.91"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.4" points="742.7,-854.97 742.77,-844.37 736.11,-852.61 742.7,-854.97"/>
+</g>
+<!-- e_51_center&#45;&gt;h_c -->
+<g id="edge172" class="edge">
+<title>e_51_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M644.77,-989.42C663.66,-997.48 748.12,-1034.08 813.19,-1071.78 866.97,-1102.93 926.35,-1145.27 958.07,-1168.59"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="956.14,-1171.51 966.26,-1174.63 960.3,-1165.88 956.14,-1171.51"/>
+</g>
+<!-- e_51_center&#45;&gt;adp_c -->
+<g id="edge171" class="edge">
+<title>e_51_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M644.67,-986.1C655.68,-981.12 688.59,-965.84 714.08,-949.97 719.5,-946.59 720.06,-944.54 725.63,-941.42 731.45,-938.16 733.06,-937.39 739.54,-935.81 750.64,-933.09 763.13,-931.57 774.03,-930.73"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="774.53,-934.21 784.29,-930.1 774.1,-927.22 774.53,-934.21"/>
+</g>
+<!-- e_51_center&#45;&gt;pi_c -->
+<g id="edge170" class="edge">
+<title>e_51_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M644.66,-987.48C659.52,-986.33 715.58,-982.15 761.83,-981.27 775.58,-981.01 790.85,-981.2 803.6,-981.49"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="803.54,-984.99 813.63,-981.75 803.72,-977.99 803.54,-984.99"/>
+</g>
+<!-- e_51_center&#45;&gt;gln__L_c -->
+<g id="edge173" class="edge">
+<title>e_51_center&#45;&gt;gln__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M643.36,-984.13C655.15,-966.61 706.48,-890.35 732.93,-851.04"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="736.1,-852.6 738.78,-842.35 730.3,-848.69 736.1,-852.6"/>
+</g>
+<!-- e_52_center&#45;&gt;h_c -->
+<g id="edge179" class="edge">
+<title>e_52_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.82" d="M881.56,-923.1C891.25,-948.69 947.74,-1097.77 971.03,-1159.25"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.82" points="967.78,-1160.56 974.6,-1168.67 974.33,-1158.08 967.78,-1160.56"/>
+</g>
+<!-- e_52_center&#45;&gt;akg_c -->
+<g id="edge177" class="edge">
+<title>e_52_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.82" d="M883.71,-920.67C894.13,-924.6 925.31,-936.78 949.34,-950.48 968.86,-961.61 973.91,-964.63 990.68,-979.58 1013.63,-1000.06 1036.66,-1026.83 1051.78,-1045.48"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.82" points="1049.17,-1047.81 1058.15,-1053.43 1054.63,-1043.44 1049.17,-1047.81"/>
+</g>
+<!-- e_52_center&#45;&gt;nadph_c -->
+<g id="edge180" class="edge">
+<title>e_52_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.82" d="M883.78,-919.64C898.21,-920.8 952.64,-925.03 997.54,-926.37 1033.53,-927.45 1075.01,-925.32 1101.82,-923.49"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.82" points="1102.3,-926.97 1112.02,-922.76 1101.8,-919.98 1102.3,-926.97"/>
+</g>
+<!-- e_52_center&#45;&gt;nh4_c -->
+<g id="edge178" class="edge">
+<title>e_52_center&#45;&gt;nh4_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.82" d="M876.48,-917.52C859.86,-909.24 789.97,-874.07 734.9,-841.2 677.43,-806.88 612.4,-762.6 578.49,-739.06"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.82" points="580.38,-736.11 570.17,-733.27 576.38,-741.86 580.38,-736.11"/>
+</g>
+<!-- e_53_center&#45;&gt;glu__L_c -->
+<g id="edge184" class="edge">
+<title>e_53_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M590.84,-849.76C605.19,-863.28 656.76,-911.65 700.68,-949.97 713.41,-961.07 727.93,-973.18 739.62,-982.81"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="737.62,-985.69 747.57,-989.33 742.06,-980.28 737.62,-985.69"/>
+</g>
+<!-- e_53_center&#45;&gt;nh4_c -->
+<g id="edge183" class="edge">
+<title>e_53_center&#45;&gt;nh4_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M586.05,-842.55C582.6,-829.19 570.22,-781.27 562.19,-750.2"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="565.54,-749.2 559.65,-740.39 558.77,-750.95 565.54,-749.2"/>
+</g>
+<!-- e_54_center&#45;&gt;glu__L_c -->
+<g id="edge190" class="edge">
+<title>e_54_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M938.98,-959.3C925.37,-967.04 876.23,-993.7 831.71,-1001.99 818.1,-1004.52 802.74,-1004.57 789.89,-1003.86"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="790.01,-1000.36 779.78,-1003.11 789.5,-1007.34 790.01,-1000.36"/>
+</g>
+<!-- e_54_center&#45;&gt;nadp_c -->
+<g id="edge189" class="edge">
+<title>e_54_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M946.38,-955.58C956.71,-951.12 986.57,-938.12 1010.94,-926.37 1043.4,-910.72 1049.41,-902.23 1083.05,-889.31 1088.58,-887.19 1094.63,-885.3 1100.46,-883.69"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1101.75,-886.97 1110.56,-881.09 1100.01,-880.19 1101.75,-886.97"/>
+</g>
+<!-- e_55_center&#45;&gt;h_c -->
+<g id="edge193" class="edge">
+<title>e_55_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M701.17,-1287.78C727.33,-1278.25 889.66,-1219.07 954.43,-1195.46"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="955.75,-1198.71 963.95,-1191.99 953.36,-1192.13 955.75,-1198.71"/>
+</g>
+<!-- e_55_center&#45;&gt;glu__L_c -->
+<g id="edge194" class="edge">
+<title>e_55_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M698.39,-1285.46C703.25,-1263.58 729.18,-1146.88 750.43,-1051.68 752.09,-1044.25 753.89,-1036.2 755.56,-1028.75"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="759.03,-1029.27 757.8,-1018.74 752.2,-1027.74 759.03,-1029.27"/>
+</g>
+<!-- 6pgc_c -->
+<g id="node121" class="node">
+<title>6pgc_c</title>
+<ellipse fill="none" stroke="black" cx="1336.79" cy="-724.73" rx="18" ry="18"/>
+<text text-anchor="middle" x="1336.79" y="-721.03" font-family="Times,serif" font-size="14.00">6pgc_c</text>
+</g>
+<!-- 6pgc_c&#45;&gt;e_56_center -->
+<g id="edge195" class="edge">
+<title>6pgc_c&#45;&gt;e_56_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1322.36,-713.53C1305.94,-700.8 1280.18,-680.82 1270.75,-673.5"/>
+</g>
+<!-- xu5p__D_c -->
+<g id="node147" class="node">
+<title>xu5p__D_c</title>
+<ellipse fill="none" stroke="black" cx="1246.76" cy="-144.93" rx="18" ry="18"/>
+<text text-anchor="middle" x="1246.76" y="-141.23" font-family="Times,serif" font-size="14.00">xu5p__D_c</text>
+</g>
+<!-- ru5p__D_c&#45;&gt;xu5p__D_c -->
+<g id="edge311" class="edge">
+<title>ru5p__D_c&#45;&gt;xu5p__D_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.02" d="M1299.59,-359.42C1289.64,-319.03 1265.35,-220.39 1253.49,-172.25"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.02" points="1256.91,-171.38 1251.1,-162.52 1250.07,-173.07 1256.91,-171.38"/>
+</g>
+<!-- e_56_center&#45;&gt;co2_c -->
+<g id="edge198" class="edge">
+<title>e_56_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1266.95,-674.39C1265.95,-694.18 1261.19,-788.49 1258.77,-836.37"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.75" points="1254.62,-836.19 1258.27,-846.39 1262.92,-836.61 1254.62,-836.19"/>
+</g>
+<!-- e_56_center&#45;&gt;nadph_c -->
+<g id="edge199" class="edge">
+<title>e_56_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1265.19,-674.24C1252.03,-698.3 1175.3,-838.53 1143.65,-896.37"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.75" points="1139.96,-894.46 1138.81,-905.23 1147.25,-898.45 1139.96,-894.46"/>
+</g>
+<!-- e_56_center&#45;&gt;ru5p__D_c -->
+<g id="edge197" class="edge">
+<title>e_56_center&#45;&gt;ru5p__D_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1267.6,-666.98C1270.98,-640.02 1291.92,-473.35 1300.41,-405.72"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.75" points="1304.58,-405.83 1301.7,-395.39 1296.33,-404.8 1304.58,-405.83"/>
+</g>
+<!-- e_58_center&#45;&gt;akg_c -->
+<g id="edge204" class="edge">
+<title>e_58_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M987.64,-989.78C997.98,-999.67 1027.99,-1028.36 1048.58,-1048.05"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.26" points="1046.3,-1050.71 1055.95,-1055.1 1051.14,-1045.66 1046.3,-1050.71"/>
+</g>
+<!-- e_58_center&#45;&gt;co2_c -->
+<g id="edge203" class="edge">
+<title>e_58_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M987.59,-985.5C1005.28,-981.61 1084.24,-963.38 1143.74,-935.29 1179.38,-918.46 1188.77,-914.65 1221.61,-892.86 1226.2,-889.82 1230.93,-886.33 1235.39,-882.86"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.26" points="1237.91,-885.33 1243.52,-876.34 1233.53,-879.87 1237.91,-885.33"/>
+</g>
+<!-- e_58_center&#45;&gt;nadph_c -->
+<g id="edge205" class="edge">
+<title>e_58_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M987.59,-984.67C1003.4,-977.64 1067.44,-949.14 1104.03,-932.86"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.26" points="1105.85,-935.88 1113.57,-928.62 1103.01,-929.48 1105.85,-935.88"/>
+</g>
+<!-- glx_c -->
+<g id="node125" class="node">
+<title>glx_c</title>
+<ellipse fill="none" stroke="black" cx="605.92" cy="-1324.92" rx="18" ry="18"/>
+<text text-anchor="middle" x="605.92" y="-1321.22" font-family="Times,serif" font-size="14.00">glx_c</text>
+</g>
+<!-- glx_c&#45;&gt;e_61_center -->
+<g id="edge215" class="edge">
+<title>glx_c&#45;&gt;e_61_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M622.26,-1316.43C673.92,-1289.56 831.84,-1207.43 857.4,-1194.13"/>
+</g>
+<!-- e_59_center&#45;&gt;succ_c -->
+<g id="edge208" class="edge">
+<title>e_59_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M521.04,-1367.22C540.9,-1380.55 637.6,-1445.49 682.9,-1475.91"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="680.98,-1478.84 691.24,-1481.51 684.89,-1473.03 680.98,-1478.84"/>
+</g>
+<!-- e_59_center&#45;&gt;glx_c -->
+<g id="edge207" class="edge">
+<title>e_59_center&#45;&gt;glx_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M521.24,-1363.08C531.23,-1358.58 558.92,-1346.1 579.94,-1336.63"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="581.65,-1339.7 589.33,-1332.4 578.77,-1333.32 581.65,-1339.7"/>
+</g>
+<!-- e_60_center&#45;&gt;h_c -->
+<g id="edge213" class="edge">
+<title>e_60_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1251.13,-1159.7C1232.62,-1161.97 1149.67,-1172.02 1081.51,-1178.29 1057.16,-1180.53 1029.43,-1182.55 1009.29,-1183.92"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1008.97,-1180.44 999.23,-1184.6 1009.44,-1187.42 1008.97,-1180.44"/>
+</g>
+<!-- e_60_center&#45;&gt;nadh_c -->
+<g id="edge212" class="edge">
+<title>e_60_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1251.2,-1156.19C1241.48,-1148.15 1214.67,-1125.46 1194.83,-1104.08 1190.59,-1099.5 1186.28,-1094.36 1182.32,-1089.4"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1184.95,-1087.09 1176.05,-1081.34 1179.43,-1091.39 1184.95,-1087.09"/>
+</g>
+<!-- e_60_center&#45;&gt;pyr_c -->
+<g id="edge211" class="edge">
+<title>e_60_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1254.31,-1155.69C1250.01,-1130.06 1223.5,-972.18 1212.56,-907.01"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1215.99,-906.31 1210.88,-897.03 1209.09,-907.47 1215.99,-906.31"/>
+</g>
+<!-- e_61_center&#45;&gt;coa_c -->
+<g id="edge217" class="edge">
+<title>e_61_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M864.42,-1190.35C880.94,-1181.16 951.77,-1141.72 990.11,-1120.37"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="992.07,-1123.29 999.1,-1115.36 988.67,-1117.17 992.07,-1123.29"/>
+</g>
+<!-- e_61_center&#45;&gt;h_c -->
+<g id="edge219" class="edge">
+<title>e_61_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M864.64,-1192.1C877.77,-1191.39 922.66,-1188.94 952.71,-1187.3"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="953.23,-1190.78 963.02,-1186.74 952.84,-1183.79 953.23,-1190.78"/>
+</g>
+<!-- e_61_center&#45;&gt;mal__L_c -->
+<g id="edge218" class="edge">
+<title>e_61_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M864.67,-1193.17C888.15,-1198.6 1015.64,-1228.07 1072.5,-1241.21"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1071.72,-1244.62 1082.26,-1243.46 1073.3,-1237.8 1071.72,-1244.62"/>
+</g>
+<!-- e_62_center&#45;&gt;h_c -->
+<g id="edge223" class="edge">
+<title>e_62_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1091.91,-1513.72C1083.72,-1490.85 1038.46,-1364.03 1004.17,-1259.75 999.11,-1244.36 993.7,-1227.09 989.39,-1213.11"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="992.61,-1211.68 986.34,-1203.14 985.92,-1213.73 992.61,-1211.68"/>
+</g>
+<!-- e_62_center&#45;&gt;mal__L_c -->
+<g id="edge222" class="edge">
+<title>e_62_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1093.3,-1513.52C1093.94,-1487.79 1097.64,-1338.67 1099.2,-1275.65"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1102.7,-1275.7 1099.45,-1265.61 1095.7,-1275.52 1102.7,-1275.7"/>
+</g>
+<!-- e_63_center&#45;&gt;h_c -->
+<g id="edge227" class="edge">
+<title>e_63_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1071.25,-1172.13C1061.14,-1173.66 1031.56,-1178.12 1009.01,-1181.53"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1008.29,-1178.1 998.93,-1183.05 1009.34,-1185.02 1008.29,-1178.1"/>
+</g>
+<!-- e_63_center&#45;&gt;nadh_c -->
+<g id="edge226" class="edge">
+<title>e_63_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1078.37,-1167.82C1090.49,-1154.99 1129.7,-1113.41 1135.01,-1107.07 1139.63,-1101.57 1144.4,-1095.45 1148.76,-1089.67"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1151.63,-1091.68 1154.78,-1081.57 1146.01,-1087.51 1151.63,-1091.68"/>
+</g>
+<!-- e_63_center&#45;&gt;oaa_c -->
+<g id="edge228" class="edge">
+<title>e_63_center&#45;&gt;oaa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1073.28,-1168.01C1068.19,-1156.33 1050.87,-1118.63 1028.98,-1092.78 1021.52,-1083.98 1016.61,-1084.88 1008.99,-1076.22 991.57,-1056.42 975.9,-1030.69 965.5,-1011.94"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="968.54,-1010.21 960.7,-1003.09 962.39,-1013.55 968.54,-1010.21"/>
+</g>
+<!-- e_64_center&#45;&gt;nadh_c -->
+<g id="edge233" class="edge">
+<title>e_64_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1285.78,-1053.93C1272.5,-1055.34 1225.17,-1060.36 1193.95,-1063.67"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1193.24,-1060.23 1183.67,-1064.76 1193.98,-1067.19 1193.24,-1060.23"/>
+</g>
+<!-- e_64_center&#45;&gt;co2_c -->
+<g id="edge231" class="edge">
+<title>e_64_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1288.75,-1049.94C1285.49,-1030.71 1270.04,-939.35 1262.09,-892.4"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1265.5,-891.57 1260.38,-882.3 1258.6,-892.74 1265.5,-891.57"/>
+</g>
+<!-- e_64_center&#45;&gt;pyr_c -->
+<g id="edge232" class="edge">
+<title>e_64_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1287.66,-1049.91C1279.04,-1031.46 1239.91,-947.61 1219.82,-904.57"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1222.9,-902.89 1215.49,-895.31 1216.55,-905.85 1222.9,-902.89"/>
+</g>
+<!-- e_65_center&#45;&gt;co2_c -->
+<g id="edge236" class="edge">
+<title>e_65_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1257.39,-1007.72C1257.39,-992.11 1257.37,-929.85 1257.36,-892.72"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1260.86,-892.53 1257.36,-882.53 1253.86,-892.53 1260.86,-892.53"/>
+</g>
+<!-- e_65_center&#45;&gt;pyr_c -->
+<g id="edge237" class="edge">
+<title>e_65_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1256.06,-1007.81C1250.71,-993.49 1230.36,-939.09 1217.87,-905.71"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1221.05,-904.23 1214.27,-896.09 1214.49,-906.68 1221.05,-904.23"/>
+</g>
+<!-- e_65_center&#45;&gt;nadph_c -->
+<g id="edge238" class="edge">
+<title>e_65_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1253.71,-1008.75C1239.17,-998.47 1184.92,-960.11 1153.3,-937.76"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1155.22,-934.83 1145.03,-931.91 1151.17,-940.54 1155.22,-934.83"/>
+</g>
+<!-- e_66_center&#45;&gt;nad_c -->
+<g id="edge242" class="edge">
+<title>e_66_center&#45;&gt;nad_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M974.68,-1338.48C978.91,-1326.71 992.25,-1289.91 1004.17,-1259.75 1006.62,-1253.55 1006.7,-1251.73 1009.94,-1245.9 1031.54,-1207.2 1042,-1200.71 1068.11,-1164.89 1080.14,-1148.4 1093.85,-1129.88 1104.33,-1115.79"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="1107.93,-1118.28 1110.4,-1107.64 1100.91,-1113.05 1107.93,-1118.28"/>
+</g>
+<!-- e_66_center&#45;&gt;h_e -->
+<g id="edge243" class="edge">
+<title>e_66_center&#45;&gt;h_e</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M974.75,-1345.94C976.21,-1349.69 978.63,-1355.88 981.17,-1362.41"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="977.2,-1364.24 984.91,-1371.97 985.35,-1361.06 977.2,-1364.24"/>
+</g>
+<!-- e_66_center&#45;&gt;q8h2_c -->
+<g id="edge244" class="edge">
+<title>e_66_center&#45;&gt;q8h2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M970.79,-1345.81C954.7,-1368.21 866.22,-1491.5 828.86,-1543.55"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="825.19,-1541.16 822.91,-1551.83 832.3,-1546.26 825.19,-1541.16"/>
+</g>
+<!-- e_67_center&#45;&gt;nadh_c -->
+<g id="edge248" class="edge">
+<title>e_67_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1294.41,-957.97C1279.3,-970.71 1219.58,-1021.03 1186.95,-1048.52"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="1184.11,-1045.2 1179.28,-1054.99 1189.75,-1051.89 1184.11,-1045.2"/>
+</g>
+<!-- e_67_center&#45;&gt;nadp_c -->
+<g id="edge247" class="edge">
+<title>e_67_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1294.39,-953.02C1282.67,-946.58 1244.26,-925.75 1211.41,-910.76 1192.83,-902.27 1171.45,-893.66 1155.07,-887.3"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="1156.48,-883.15 1145.58,-883.65 1153.34,-891.32 1156.48,-883.15"/>
+</g>
+<!-- e_70_center&#45;&gt;nadh_c -->
+<g id="edge255" class="edge">
+<title>e_70_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.7" d="M1196.1,-1000.29C1192.6,-1007.86 1184.45,-1025.46 1177.43,-1040.65"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.7" points="1174.06,-1039.6 1173.03,-1050.15 1180.41,-1042.54 1174.06,-1039.6"/>
+</g>
+<!-- e_70_center&#45;&gt;accoa_c -->
+<g id="edge256" class="edge">
+<title>e_70_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.7" d="M1194.19,-997.89C1175.83,-1004.8 1092.88,-1036.03 1049.5,-1052.36"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.7" points="1048.01,-1049.18 1039.88,-1055.98 1050.47,-1055.74 1048.01,-1049.18"/>
+</g>
+<!-- e_70_center&#45;&gt;co2_c -->
+<g id="edge254" class="edge">
+<title>e_70_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.7" d="M1199.43,-992.98C1205.93,-978.56 1230.78,-923.39 1245.74,-890.18"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.7" points="1248.94,-891.6 1249.86,-881.05 1242.56,-888.73 1248.94,-891.6"/>
+</g>
+<!-- e_71_center&#45;&gt;h_c -->
+<g id="edge261" class="edge">
+<title>e_71_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.77" d="M900.54,-788.34C901.27,-799.95 903.79,-836.25 908.27,-866.04 924.77,-975.78 958.35,-1103.77 973.44,-1158.59"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="0.77" points="970.07,-1159.55 976.11,-1168.25 976.82,-1157.68 970.07,-1159.55"/>
+</g>
+<!-- e_71_center&#45;&gt;adp_c -->
+<g id="edge260" class="edge">
+<title>e_71_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.77" d="M897.89,-788.18C887.09,-804.19 842.73,-869.94 818.46,-905.92"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="0.77" points="815.45,-904.13 812.76,-914.37 821.25,-908.04 815.45,-904.13"/>
+</g>
+<!-- e_71_center&#45;&gt;fdp_c -->
+<g id="edge259" class="edge">
+<title>e_71_center&#45;&gt;fdp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.77" d="M899.55,-780.83C894.05,-753.35 859.86,-582.82 846.23,-514.78"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="0.77" points="849.62,-513.9 844.22,-504.78 842.75,-515.27 849.62,-513.9"/>
+</g>
+<!-- e_72_center&#45;&gt;accoa_c -->
+<g id="edge265" class="edge">
+<title>e_72_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1277.86,-1120.69C1260.44,-1121.98 1182.52,-1126.69 1121.11,-1112.72 1114.61,-1111.24 1113.36,-1109.64 1107.29,-1106.88 1083.88,-1096.25 1077.91,-1093.74 1055.26,-1081.55 1052.53,-1080.08 1049.7,-1078.5 1046.9,-1076.89"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1048.61,-1073.84 1038.21,-1071.81 1045.08,-1079.88 1048.61,-1073.84"/>
+</g>
+<!-- e_72_center&#45;&gt;for_c -->
+<g id="edge264" class="edge">
+<title>e_72_center&#45;&gt;for_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1284.4,-1123.91C1303.47,-1146.41 1409.19,-1271.12 1452.38,-1322.06"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1449.85,-1324.48 1458.98,-1329.85 1455.19,-1319.96 1449.85,-1324.48"/>
+</g>
+<!-- e_74_center&#45;&gt;adp_c -->
+<g id="edge269" class="edge">
+<title>e_74_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.27" d="M742.29,-694.8C748.29,-718.25 780.88,-845.58 795.41,-902.36"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.27" points="792.03,-903.28 797.9,-912.1 798.81,-901.54 792.03,-903.28"/>
+</g>
+<!-- e_74_center&#45;&gt;13dpg_c -->
+<g id="edge270" class="edge">
+<title>e_74_center&#45;&gt;13dpg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.27" d="M745.04,-689.01C762.71,-679.26 839.19,-637.07 879.39,-614.9"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.27" points="881.24,-617.87 888.3,-609.98 877.86,-611.74 881.24,-617.87"/>
+</g>
+<!-- e_75_center&#45;&gt;h_c -->
+<g id="edge274" class="edge">
+<title>e_75_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1087,-899.88C1074.63,-917.51 1023.86,-992.41 1003.27,-1062.35 993.86,-1094.33 987.77,-1132.2 984.39,-1157.48"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.75" points="980.25,-1157.04 983.1,-1167.48 988.5,-1158.09 980.25,-1157.04"/>
+</g>
+<!-- e_75_center&#45;&gt;6pgc_c -->
+<g id="edge273" class="edge">
+<title>e_75_center&#45;&gt;6pgc_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1092,-892.24C1095.99,-885.77 1104.82,-872.41 1114.75,-863.38 1177.92,-805.99 1267.9,-758.18 1311.36,-736.79"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.75" points="1313.21,-740.5 1320.39,-732.39 1309.58,-733.03 1313.21,-740.5"/>
+</g>
+<!-- e_77_center&#45;&gt;h_c -->
+<g id="edge279" class="edge">
+<title>e_77_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.25" d="M741.49,-1308.39C765.79,-1295.95 899.47,-1227.52 955.91,-1198.63"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.25" points="957.59,-1201.7 964.89,-1194.03 954.4,-1195.47 957.59,-1201.7"/>
+</g>
+<!-- e_77_center&#45;&gt;pi_c -->
+<g id="edge278" class="edge">
+<title>e_77_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.25" d="M738.49,-1306.67C743.52,-1284.48 770.67,-1166.26 799.79,-1071.78 806.37,-1050.45 814.92,-1026.67 821.53,-1009"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.25" points="824.9,-1009.96 825.16,-999.37 818.35,-1007.49 824.9,-1009.96"/>
+</g>
+<!-- e_78_center&#45;&gt;h_c -->
+<g id="edge284" class="edge">
+<title>e_78_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.84" d="M1003.91,-923.44C1001.71,-948.7 989.01,-1094.58 983.56,-1157.21"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="0.84" points="980.04,-1157.28 982.66,-1167.54 987.01,-1157.88 980.04,-1157.28"/>
+</g>
+<!-- e_78_center&#45;&gt;pi_c -->
+<g id="edge283" class="edge">
+<title>e_78_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.84" d="M1000.64,-920.98C982.59,-927.55 901.16,-957.15 858.3,-972.73"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="0.84" points="856.99,-969.48 848.79,-976.19 859.38,-976.06 856.99,-969.48"/>
+</g>
+<!-- e_78_center&#45;&gt;oaa_c -->
+<g id="edge285" class="edge">
+<title>e_78_center&#45;&gt;oaa_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.84" d="M1001.46,-923.29C995.54,-930.97 981.3,-949.46 969.68,-964.54"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="0.84" points="966.9,-962.41 963.57,-972.47 972.45,-966.68 966.9,-962.41"/>
+</g>
+<!-- e_79_center&#45;&gt;adp_c -->
+<g id="edge289" class="edge">
+<title>e_79_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M976.66,-796.4C957.33,-811.2 867.53,-879.9 824.94,-912.48"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="822.66,-909.82 816.85,-918.67 826.92,-915.37 822.66,-909.82"/>
+</g>
+<!-- e_79_center&#45;&gt;co2_c -->
+<g id="edge288" class="edge">
+<title>e_79_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M983.88,-794.46C1009.27,-800.95 1165.93,-841.01 1230.04,-857.41"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1229.3,-860.83 1239.85,-859.92 1231.03,-854.05 1229.3,-860.83"/>
+</g>
+<!-- e_79_center&#45;&gt;pep_c -->
+<g id="edge290" class="edge">
+<title>e_79_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M983.4,-789.88C994.12,-776.83 1030.85,-732.12 1053.28,-704.81"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1056.09,-706.9 1059.74,-696.95 1050.69,-702.45 1056.09,-706.9"/>
+</g>
+<!-- e_80_center&#45;&gt;h_c -->
+<g id="edge297" class="edge">
+<title>e_80_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.78" d="M915.34,-862.91C916.94,-878 923.58,-938.03 932.87,-986.74 944.69,-1048.66 963.26,-1120.29 973.56,-1158.46"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.78" points="970.24,-1159.57 976.23,-1168.31 976.99,-1157.74 970.24,-1159.57"/>
+</g>
+<!-- e_80_center&#45;&gt;amp_c -->
+<g id="edge295" class="edge">
+<title>e_80_center&#45;&gt;amp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.78" d="M911.4,-855.45C893.92,-836.4 815.37,-751.21 748.03,-684.35 738.78,-675.18 728.31,-665.26 719.37,-656.93"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.78" points="721.68,-654.3 711.97,-650.07 716.93,-659.44 721.68,-654.3"/>
+</g>
+<!-- e_80_center&#45;&gt;pi_c -->
+<g id="edge294" class="edge">
+<title>e_80_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.78" d="M911.78,-863.1C904.58,-871.64 886.69,-893.28 873.44,-912.64 863.46,-927.2 853.28,-944.19 845.47,-957.76"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.78" points="842.38,-956.11 840.47,-966.53 848.46,-959.57 842.38,-956.11"/>
+</g>
+<!-- e_80_center&#45;&gt;pep_c -->
+<g id="edge296" class="edge">
+<title>e_80_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.78" d="M917.81,-855.64C926.14,-844.84 951.32,-812.49 973.68,-786.86 999.79,-756.93 1031.51,-723.68 1051.54,-703.04"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.78" points="1054.14,-705.38 1058.61,-695.78 1049.13,-700.5 1054.14,-705.38"/>
+</g>
+<!-- e_81_center&#45;&gt;coa_c -->
+<g id="edge300" class="edge">
+<title>e_81_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M763.52,-1125.01C776.22,-1124.74 819.64,-1123.68 855.41,-1121.31 901.36,-1118.28 954.59,-1112.98 986.49,-1109.62"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="987.26,-1113.06 996.83,-1108.52 986.52,-1106.09 987.26,-1113.06"/>
+</g>
+<!-- e_81_center&#45;&gt;actp_c -->
+<g id="edge301" class="edge">
+<title>e_81_center&#45;&gt;actp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M755.98,-1125.54C740.59,-1127.34 682.5,-1134.03 634.59,-1138.62 589.35,-1142.95 536.74,-1147.17 505.19,-1149.62"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="504.66,-1146.15 494.96,-1150.41 505.2,-1153.13 504.66,-1146.15"/>
+</g>
+<!-- e_82_center&#45;&gt;atp_c -->
+<g id="edge306" class="edge">
+<title>e_82_center&#45;&gt;atp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M974.79,-893.69C953.39,-892.59 844.94,-887.02 792.69,-884.33"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="792.62,-880.82 782.45,-883.8 792.26,-887.81 792.62,-880.82"/>
+</g>
+<!-- e_82_center&#45;&gt;pyr_c -->
+<g id="edge305" class="edge">
+<title>e_82_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M982.18,-894.6C996.69,-897.33 1051.46,-906.77 1096.45,-902.71 1110.88,-901.41 1114.32,-899.78 1128.52,-896.88 1145.83,-893.35 1165.17,-888.98 1180.42,-885.43"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1181.31,-888.82 1190.24,-883.13 1179.71,-882 1181.31,-888.82"/>
+</g>
+<!-- e_83_center&#45;&gt;h_c -->
+<g id="edge310" class="edge">
+<title>e_83_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1284,-1201.37C1255.62,-1199.91 1079.18,-1190.81 1009.41,-1187.21"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1009.34,-1183.71 999.17,-1186.69 1008.98,-1190.7 1009.34,-1183.71"/>
+</g>
+<!-- e_83_center&#45;&gt;pyr_c -->
+<g id="edge309" class="edge">
+<title>e_83_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1286.98,-1197.95C1279.88,-1169.31 1232.59,-978.7 1214.69,-906.53"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1218.08,-905.64 1212.27,-896.78 1211.28,-907.33 1218.08,-905.64"/>
+</g>
+<!-- xu5p__D_c&#45;&gt;e_92_center -->
+<g id="edge341" class="edge">
+<title>xu5p__D_c&#45;&gt;e_92_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.91" d="M1231.35,-154.43C1201.24,-173 1136.16,-213.12 1120.36,-222.86"/>
+</g>
+<!-- xu5p__D_c&#45;&gt;e_93_center -->
+<g id="edge346" class="edge">
+<title>xu5p__D_c&#45;&gt;e_93_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.85" d="M1235.6,-159.34C1207.29,-195.92 1133.82,-290.82 1118.64,-310.43"/>
+</g>
+<!-- e_86_center&#45;&gt;h_c -->
+<g id="edge315" class="edge">
+<title>e_86_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M905.7,-1516.98C912.5,-1487.11 957.91,-1287.52 974.78,-1213.4"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="978.25,-1213.94 977.05,-1203.41 971.42,-1212.38 978.25,-1213.94"/>
+</g>
+<!-- e_86_center&#45;&gt;succ_c -->
+<g id="edge316" class="edge">
+<title>e_86_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M901.06,-1520.18C880.69,-1517.2 783.27,-1502.94 734.44,-1495.79"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="734.92,-1492.32 724.52,-1494.34 733.91,-1499.25 734.92,-1492.32"/>
+</g>
+<!-- e_87_center&#45;&gt;h_c -->
+<g id="edge320" class="edge">
+<title>e_87_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M878.48,-1504.6C887.71,-1475.91 949.27,-1284.6 972.35,-1212.86"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="975.73,-1213.77 975.46,-1203.18 969.07,-1211.62 975.73,-1213.77"/>
+</g>
+<!-- e_87_center&#45;&gt;succ_e -->
+<g id="edge319" class="edge">
+<title>e_87_center&#45;&gt;succ_e</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M876.91,-1511.73C873.97,-1537.04 855.88,-1692.63 848.35,-1757.35"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="844.84,-1757.29 847.16,-1767.63 851.79,-1758.1 844.84,-1757.29"/>
+</g>
+<!-- e_88_center&#45;&gt;q8h2_c -->
+<g id="edge323" class="edge">
+<title>e_88_center&#45;&gt;q8h2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M668.82,-1677.69C682.18,-1667.13 727.9,-1631.06 766.01,-1601.73 773.57,-1595.91 781.87,-1589.6 789.33,-1583.96"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="791.72,-1586.54 797.6,-1577.72 787.51,-1580.95 791.72,-1586.54"/>
+</g>
+<!-- e_88_center&#45;&gt;fum_c -->
+<g id="edge324" class="edge">
+<title>e_88_center&#45;&gt;fum_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M668.55,-1678.71C681.39,-1671.43 726.12,-1646.1 754.78,-1629.86"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="756.83,-1632.72 763.81,-1624.75 753.38,-1626.63 756.83,-1632.72"/>
+</g>
+<!-- e_89_center&#45;&gt;adp_c -->
+<g id="edge329" class="edge">
+<title>e_89_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M807.9,-1162.35C806.27,-1150.91 801.38,-1115.07 799.79,-1085.18 797.43,-1040.81 799.19,-989.23 800.74,-958.05"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="804.24,-958.09 801.28,-947.92 797.25,-957.72 804.24,-958.09"/>
+</g>
+<!-- e_89_center&#45;&gt;succoa_c -->
+<g id="edge330" class="edge">
+<title>e_89_center&#45;&gt;succoa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M811.96,-1167.04C821.21,-1169.7 846.93,-1177.31 867.61,-1185.61 914.87,-1204.56 968.07,-1230.97 998.58,-1246.64"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="997.16,-1249.84 1007.65,-1251.32 1000.37,-1243.62 997.16,-1249.84"/>
+</g>
+<!-- e_89_center&#45;&gt;pi_c -->
+<g id="edge328" class="edge">
+<title>e_89_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M808.88,-1162.54C811.23,-1143.99 822.34,-1056.41 828.16,-1010.55"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="831.67,-1010.74 829.45,-1000.38 824.72,-1009.86 831.67,-1010.74"/>
+</g>
+<!-- s7p_c -->
+<g id="node152" class="node">
+<title>s7p_c</title>
+<ellipse fill="none" stroke="black" cx="1091.98" cy="-39.09" rx="18" ry="18"/>
+<text text-anchor="middle" x="1091.98" y="-35.39" font-family="Times,serif" font-size="14.00">s7p_c</text>
+</g>
+<!-- s7p_c&#45;&gt;e_90_center -->
+<g id="edge331" class="edge">
+<title>s7p_c&#45;&gt;e_90_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.91" d="M1088.56,-57.16C1078.9,-108.28 1051.78,-251.76 1047.19,-276.04"/>
+</g>
+<!-- e_90_center&#45;&gt;f6p_c -->
+<g id="edge334" class="edge">
+<title>e_90_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.91" d="M1046.11,-283.2C1043.92,-302.56 1033.87,-395.18 1033.61,-471.22 1033.55,-486.7 1034.52,-503.95 1035.58,-518"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.91" points="1032.1,-518.35 1036.39,-528.03 1039.07,-517.79 1032.1,-518.35"/>
+</g>
+<!-- e_90_center&#45;&gt;e4p_c -->
+<g id="edge333" class="edge">
+<title>e_90_center&#45;&gt;e4p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.91" d="M1046.66,-283.22C1047.34,-302.72 1050.56,-395.32 1052.22,-442.92"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.91" points="1048.73,-443.29 1052.57,-453.16 1055.72,-443.05 1048.73,-443.29"/>
+</g>
+<!-- e_91_center&#45;&gt;nad_c -->
+<g id="edge338" class="edge">
+<title>e_91_center&#45;&gt;nad_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1116.48,-1137.76C1116.88,-1134.01 1117.53,-1127.92 1118.22,-1121.42"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1121.74,-1121.47 1119.32,-1111.16 1114.78,-1120.73 1121.74,-1121.47"/>
+</g>
+<!-- e_91_center&#45;&gt;h_c -->
+<g id="edge339" class="edge">
+<title>e_91_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1112.46,-1142.74C1097.87,-1147.52 1042.41,-1165.67 1008.38,-1176.81"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1006.99,-1173.58 998.58,-1180.02 1009.17,-1180.23 1006.99,-1173.58"/>
+</g>
+<!-- e_91_center&#45;&gt;nadph_c -->
+<g id="edge340" class="edge">
+<title>e_91_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1114.24,-1137.64C1110.61,-1129.52 1102.72,-1110.19 1101.65,-1092.99 1098.43,-1041.56 1112.09,-982.46 1121.57,-948.73"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1125.05,-949.29 1124.47,-938.71 1118.33,-947.34 1125.05,-949.29"/>
+</g>
+<!-- e_92_center&#45;&gt;g3p_c -->
+<g id="edge344" class="edge">
+<title>e_92_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.91" d="M1115.1,-228.71C1104.04,-251.98 1043.5,-379.3 1017.33,-434.34"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.91" points="1014.14,-432.9 1013.01,-443.43 1020.46,-435.91 1014.14,-432.9"/>
+</g>
+<!-- e_92_center&#45;&gt;s7p_c -->
+<g id="edge343" class="edge">
+<title>e_92_center&#45;&gt;s7p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.91" d="M1116.38,-221.48C1113.85,-202.61 1101.89,-113.21 1095.71,-66.96"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.91" points="1099.17,-66.44 1094.37,-56.99 1092.23,-67.37 1099.17,-66.44"/>
+</g>
+<!-- e_93_center&#45;&gt;f6p_c -->
+<g id="edge348" class="edge">
+<title>e_93_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.85" d="M1115.19,-317.88C1111.76,-336.83 1095.47,-421.42 1067,-485.23 1061.78,-496.94 1055.74,-509.78 1050.55,-520.65"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.85" points="1047.24,-519.46 1046.06,-529.99 1053.55,-522.49 1047.24,-519.46"/>
+</g>
+<!-- e_93_center&#45;&gt;g3p_c -->
+<g id="edge347" class="edge">
+<title>e_93_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.85" d="M1113.14,-317.61C1100.81,-333.85 1049.81,-401.03 1022.59,-436.9"/>
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diff --git a/jupyter_execute/c0a2bcef604ae3b0817afcfb97fcec57469cdf598b7734ff90c891e19dea50fa.svg b/jupyter_execute/c0a2bcef604ae3b0817afcfb97fcec57469cdf598b7734ff90c891e19dea50fa.svg
new file mode 100644
index 00000000..c14290cb
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+++ b/jupyter_execute/c0a2bcef604ae3b0817afcfb97fcec57469cdf598b7734ff90c891e19dea50fa.svg
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+<!-- coa_c -->
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+</g>
+<!-- coa_c&#45;&gt;e_0_center -->
+<g id="edge1" class="edge">
+<title>coa_c&#45;&gt;e_0_center</title>
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+</g>
+<!-- coa_c&#45;&gt;e_7_center -->
+<g id="edge25" class="edge">
+<title>coa_c&#45;&gt;e_7_center</title>
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+<!-- e_70_center -->
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+</g>
+<!-- coa_c&#45;&gt;e_70_center -->
+<g id="edge251" class="edge">
+<title>coa_c&#45;&gt;e_70_center</title>
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+<!-- e_72_center -->
+<g id="node137" class="node">
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+</g>
+<!-- coa_c&#45;&gt;e_72_center -->
+<g id="edge262" class="edge">
+<title>coa_c&#45;&gt;e_72_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1033.02,-1107.63C1054.13,-1108.92 1090.15,-1111.07 1121.11,-1112.72 1183.44,-1116.03 1259.43,-1119.43 1277.46,-1120.23"/>
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+<!-- e_89_center -->
+<g id="node151" class="node">
+<title>e_89_center</title>
+<polygon fill="none" stroke="black" points="811.94,-1169.54 804.94,-1169.54 804.94,-1162.54 811.94,-1162.54 811.94,-1169.54"/>
+</g>
+<!-- coa_c&#45;&gt;e_89_center -->
+<g id="edge325" class="edge">
+<title>coa_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M997.38,-1111.59C952.31,-1124.58 834.73,-1158.46 812.2,-1164.96"/>
+</g>
+<!-- acald_c -->
+<g id="node2" class="node">
+<title>acald_c</title>
+<ellipse fill="none" stroke="black" cx="1557.48" cy="-1324.36" rx="18" ry="18"/>
+<text text-anchor="middle" x="1557.48" y="-1320.66" font-family="Times,serif" font-size="14.00">acald_c</text>
+</g>
+<!-- acald_c&#45;&gt;e_0_center -->
+<g id="edge2" class="edge">
+<title>acald_c&#45;&gt;e_0_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1540.07,-1318.18C1476.47,-1295.61 1258.82,-1218.39 1228.53,-1207.64"/>
+</g>
+<!-- nad_c -->
+<g id="node3" class="node">
+<title>nad_c</title>
+<ellipse fill="none" stroke="black" cx="1121.25" cy="-1093.12" rx="18" ry="18"/>
+<text text-anchor="middle" x="1121.25" y="-1089.42" font-family="Times,serif" font-size="14.00">nad_c</text>
+</g>
+<!-- nad_c&#45;&gt;e_0_center -->
+<g id="edge3" class="edge">
+<title>nad_c&#45;&gt;e_0_center</title>
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+</g>
+<!-- nad_c&#45;&gt;e_7_center -->
+<g id="edge27" class="edge">
+<title>nad_c&#45;&gt;e_7_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1139.47,-1094.09C1158.71,-1095.11 1187.66,-1096.64 1197.84,-1097.18"/>
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+<!-- e_9_center -->
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+</g>
+<!-- nad_c&#45;&gt;e_9_center -->
+<g id="edge35" class="edge">
+<title>nad_c&#45;&gt;e_9_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1132.09,-1107.6C1149.52,-1130.6 1185.15,-1176.62 1218.32,-1213.1 1239.91,-1236.83 1268.31,-1263.05 1278.2,-1272.04"/>
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+<!-- e_12_center -->
+<g id="node49" class="node">
+<title>e_12_center</title>
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+</g>
+<!-- nad_c&#45;&gt;e_12_center -->
+<g id="edge61" class="edge">
+<title>nad_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1113.13,-1076.92C1086.63,-1024.05 1003.57,-858.33 990.12,-831.5"/>
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+<!-- e_48_center -->
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+<!-- nad_c&#45;&gt;e_48_center -->
+<g id="edge151" class="edge">
+<title>nad_c&#45;&gt;e_48_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1114.51,-1076.22C1094.26,-1025.45 1034.73,-876.22 1024.65,-850.94"/>
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+<!-- e_60_center -->
+<g id="node127" class="node">
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+</g>
+<!-- nad_c&#45;&gt;e_60_center -->
+<g id="edge210" class="edge">
+<title>nad_c&#45;&gt;e_60_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M1137.64,-1101.23C1168.87,-1116.67 1235.23,-1149.5 1251.33,-1157.47"/>
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+<!-- e_63_center -->
+<g id="node130" class="node">
+<title>e_63_center</title>
+<polygon fill="none" stroke="black" points="1078.31,-1175.09 1071.31,-1175.09 1071.31,-1168.09 1078.31,-1168.09 1078.31,-1175.09"/>
+</g>
+<!-- nad_c&#45;&gt;e_63_center -->
+<g id="edge224" class="edge">
+<title>nad_c&#45;&gt;e_63_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1112.07,-1108.62C1100.97,-1127.38 1083.01,-1157.74 1076.91,-1168.04"/>
+</g>
+<!-- e_64_center -->
+<g id="node131" class="node">
+<title>e_64_center</title>
+<polygon fill="none" stroke="black" points="1292.86,-1057.05 1285.86,-1057.05 1285.86,-1050.05 1292.86,-1050.05 1292.86,-1057.05"/>
+</g>
+<!-- nad_c&#45;&gt;e_64_center -->
+<g id="edge229" class="edge">
+<title>nad_c&#45;&gt;e_64_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1139.34,-1090.76C1147.33,-1089.6 1156.83,-1088.08 1165.32,-1086.3 1213.29,-1076.29 1270.42,-1059.3 1285.54,-1054.72"/>
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+<!-- e_67_center -->
+<g id="node134" class="node">
+<title>e_67_center</title>
+<polygon fill="none" stroke="black" points="1301.46,-958.49 1294.46,-958.49 1294.46,-951.49 1301.46,-951.49 1301.46,-958.49"/>
+</g>
+<!-- nad_c&#45;&gt;e_67_center -->
+<g id="edge245" class="edge">
+<title>nad_c&#45;&gt;e_67_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1131.09,-1077.58C1136.55,-1069.65 1143.79,-1060.15 1151.56,-1052.8 1201.3,-1005.75 1276.08,-966.15 1294,-956.98"/>
+</g>
+<!-- nad_c&#45;&gt;e_70_center -->
+<g id="edge253" class="edge">
+<title>nad_c&#45;&gt;e_70_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1132.04,-1078.45C1137.76,-1070.75 1144.95,-1061.2 1151.56,-1052.8 1167.51,-1032.52 1187.43,-1008.82 1194.86,-1000.03"/>
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+<!-- h_c -->
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+<title>h_c</title>
+<ellipse fill="none" stroke="black" cx="981.07" cy="-1185.75" rx="18" ry="18"/>
+<text text-anchor="middle" x="981.07" y="-1182.05" font-family="Times,serif" font-size="14.00">h_c</text>
+</g>
+<!-- e_15_center -->
+<g id="node55" class="node">
+<title>e_15_center</title>
+<polygon fill="none" stroke="black" points="745.45,-1389.39 738.45,-1389.39 738.45,-1382.39 745.45,-1382.39 745.45,-1389.39"/>
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+<!-- h_c&#45;&gt;e_15_center -->
+<g id="edge82" class="edge">
+<title>h_c&#45;&gt;e_15_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M967.81,-1198.61C943.2,-1222.26 888.53,-1273.92 839.49,-1314.03 804.32,-1342.79 759.06,-1374.18 745.78,-1383.28"/>
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+<!-- e_54_center -->
+<g id="node119" class="node">
+<title>e_54_center</title>
+<polygon fill="none" stroke="black" points="946.14,-960.68 939.14,-960.68 939.14,-953.68 946.14,-953.68 946.14,-960.68"/>
+</g>
+<!-- h_c&#45;&gt;e_54_center -->
+<g id="edge186" class="edge">
+<title>h_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M973.68,-1169.04C959.49,-1135.22 930.04,-1056 932.87,-986.74 933.27,-977.02 937.94,-966.35 940.68,-960.88"/>
+</g>
+<!-- e_66_center -->
+<g id="node133" class="node">
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+</g>
+<!-- h_c&#45;&gt;e_66_center -->
+<g id="edge241" class="edge">
+<title>h_c&#45;&gt;e_66_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M980.17,-1204.01C978.36,-1240.47 974.41,-1320.32 973.51,-1338.53"/>
+</g>
+<!-- e_82_center -->
+<g id="node145" class="node">
+<title>e_82_center</title>
+<polygon fill="none" stroke="black" points="982,-897.39 975,-897.39 975,-890.39 982,-890.39 982,-897.39"/>
+</g>
+<!-- h_c&#45;&gt;e_82_center -->
+<g id="edge304" class="edge">
+<title>h_c&#45;&gt;e_82_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M980.42,-1167.55C979.21,-1131.62 976.78,-1049.03 977.28,-979.58 977.5,-947.74 978.21,-909.25 978.43,-897.48"/>
+</g>
+<!-- nadh_c -->
+<g id="node5" class="node">
+<title>nadh_c</title>
+<ellipse fill="none" stroke="black" cx="1165.38" cy="-1066.7" rx="18" ry="18"/>
+<text text-anchor="middle" x="1165.38" y="-1063" font-family="Times,serif" font-size="14.00">nadh_c</text>
+</g>
+<!-- nadh_c&#45;&gt;e_66_center -->
+<g id="edge240" class="edge">
+<title>nadh_c&#45;&gt;e_66_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1157.58,-1082.94C1149.42,-1099.62 1135.97,-1126.19 1122.77,-1148.26 1088.18,-1206.09 1079.69,-1221.07 1037.59,-1273.69 1016.39,-1300.2 987.21,-1328.91 977.01,-1338.75"/>
+</g>
+<!-- e_91_center -->
+<g id="node154" class="node">
+<title>e_91_center</title>
+<polygon fill="none" stroke="black" points="1119.57,-1145.06 1112.57,-1145.06 1112.57,-1138.06 1119.57,-1138.06 1119.57,-1145.06"/>
+</g>
+<!-- nadh_c&#45;&gt;e_91_center -->
+<g id="edge337" class="edge">
+<title>nadh_c&#45;&gt;e_91_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1155.4,-1081.85C1143.69,-1099.62 1125.05,-1127.93 1118.47,-1137.92"/>
+</g>
+<!-- accoa_c -->
+<g id="node6" class="node">
+<title>accoa_c</title>
+<ellipse fill="none" stroke="black" cx="1022.87" cy="-1062.38" rx="18" ry="18"/>
+<text text-anchor="middle" x="1022.87" y="-1058.68" font-family="Times,serif" font-size="14.00">accoa_c</text>
+</g>
+<!-- accoa_c&#45;&gt;e_12_center -->
+<g id="edge55" class="edge">
+<title>accoa_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1018.99,-1044.43C1013.51,-1018.48 1003.5,-968.95 997.54,-926.37 992.4,-889.61 989.34,-844.72 988.51,-831.59"/>
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+<!-- e_14_center -->
+<g id="node51" class="node">
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+<polygon fill="none" stroke="black" points="809.99,-1081.98 802.99,-1081.98 802.99,-1074.98 809.99,-1074.98 809.99,-1081.98"/>
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+<!-- accoa_c&#45;&gt;e_14_center -->
+<g id="edge76" class="edge">
+<title>accoa_c&#45;&gt;e_14_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1004.8,-1063.73C957.67,-1067.23 833.09,-1076.5 810.15,-1078.21"/>
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+<!-- e_61_center -->
+<g id="node128" class="node">
+<title>e_61_center</title>
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+</g>
+<!-- accoa_c&#45;&gt;e_61_center -->
+<g id="edge216" class="edge">
+<title>accoa_c&#45;&gt;e_61_center</title>
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+<!-- e_81_center -->
+<g id="node144" class="node">
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+<!-- accoa_c&#45;&gt;e_81_center -->
+<g id="edge299" class="edge">
+<title>accoa_c&#45;&gt;e_81_center</title>
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+</g>
+<!-- e_0_center&#45;&gt;h_c -->
+<g id="edge4" class="edge">
+<title>e_0_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1221.19,-1206.07C1197.27,-1204.05 1067.61,-1193.08 1009.39,-1188.15"/>
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+<!-- e_0_center&#45;&gt;nadh_c -->
+<g id="edge5" class="edge">
+<title>e_0_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1223.43,-1202.66C1216.85,-1187.26 1191.49,-1127.87 1176.55,-1092.88"/>
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+<!-- e_0_center&#45;&gt;accoa_c -->
+<g id="edge6" class="edge">
+<title>e_0_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1221.51,-1203.9C1200.78,-1189.13 1093.61,-1112.78 1045.87,-1078.76"/>
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+<!-- acald_e -->
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+<!-- acald_e&#45;&gt;acald_c -->
+<g id="edge7" class="edge">
+<title>acald_e&#45;&gt;acald_c</title>
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+<title>e_20_target</title>
+<ellipse fill="black" stroke="black" cx="2159.66" cy="-1507.22" rx="1.8" ry="1.8"/>
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+<!-- acald_e&#45;&gt;e_20_target -->
+<g id="edge99" class="edge">
+<title>acald_e&#45;&gt;e_20_target</title>
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+<!-- ac_c -->
+<g id="node9" class="node">
+<title>ac_c</title>
+<ellipse fill="none" stroke="black" cx="464.62" cy="-1287.85" rx="18" ry="18"/>
+<text text-anchor="middle" x="464.62" y="-1284.15" font-family="Times,serif" font-size="14.00">ac_c</text>
+</g>
+<!-- e_2_center -->
+<g id="node13" class="node">
+<title>e_2_center</title>
+<polygon fill="none" stroke="black" points="567.08,-1052.48 560.08,-1052.48 560.08,-1045.48 567.08,-1045.48 567.08,-1052.48"/>
+</g>
+<!-- ac_c&#45;&gt;e_2_center -->
+<g id="edge8" class="edge">
+<title>ac_c&#45;&gt;e_2_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M471.58,-1271.05C492.17,-1221.35 551.98,-1076.96 562.11,-1052.52"/>
+</g>
+<!-- atp_c -->
+<g id="node10" class="node">
+<title>atp_c</title>
+<ellipse fill="none" stroke="black" cx="764.47" cy="-882.88" rx="18" ry="18"/>
+<text text-anchor="middle" x="764.47" y="-879.18" font-family="Times,serif" font-size="14.00">atp_c</text>
+</g>
+<!-- atp_c&#45;&gt;e_2_center -->
+<g id="edge9" class="edge">
+<title>atp_c&#45;&gt;e_2_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M749.57,-893.23C724.9,-910.55 674.3,-946.91 634.2,-981.08 607.02,-1004.25 576.91,-1035.1 566.96,-1045.43"/>
+</g>
+<!-- e_6_center -->
+<g id="node24" class="node">
+<title>e_6_center</title>
+<polygon fill="none" stroke="black" points="635.87,-749.15 628.87,-749.15 628.87,-742.15 635.87,-742.15 635.87,-749.15"/>
+</g>
+<!-- atp_c&#45;&gt;e_6_center -->
+<g id="edge23" class="edge">
+<title>atp_c&#45;&gt;e_6_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M751.8,-869.72C722.87,-839.67 653.13,-767.22 636.15,-749.57"/>
+</g>
+<!-- e_10_center -->
+<g id="node34" class="node">
+<title>e_10_center</title>
+<polygon fill="none" stroke="black" points="760.63,-1061.88 753.63,-1061.88 753.63,-1054.88 760.63,-1054.88 760.63,-1061.88"/>
+</g>
+<!-- atp_c&#45;&gt;e_10_center -->
+<g id="edge41" class="edge">
+<title>atp_c&#45;&gt;e_10_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M764.49,-901.01C764.18,-915.84 762.96,-937.28 758.96,-955.58 754.38,-976.54 743.28,-979.42 742.2,-1000.85 741.14,-1021.87 751.25,-1045.92 755.4,-1054.83"/>
+</g>
+<!-- atp_c&#45;&gt;e_12_center -->
+<g id="edge64" class="edge">
+<title>atp_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M782.03,-878.56C830.05,-866.74 961.51,-834.4 984.74,-828.68"/>
+</g>
+<!-- e_50_center -->
+<g id="node115" class="node">
+<title>e_50_center</title>
+<polygon fill="none" stroke="black" points="710.88,-946.77 703.88,-946.77 703.88,-939.77 710.88,-939.77 710.88,-946.77"/>
+</g>
+<!-- atp_c&#45;&gt;e_50_center -->
+<g id="edge160" class="edge">
+<title>atp_c&#45;&gt;e_50_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M752.08,-895.98C738.97,-909.86 719.06,-930.91 710.98,-939.46"/>
+</g>
+<!-- e_51_center -->
+<g id="node116" class="node">
+<title>e_51_center</title>
+<polygon fill="none" stroke="black" points="644.4,-991.28 637.4,-991.28 637.4,-984.28 644.4,-984.28 644.4,-991.28"/>
+</g>
+<!-- atp_c&#45;&gt;e_51_center -->
+<g id="edge169" class="edge">
+<title>atp_c&#45;&gt;e_51_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M750.51,-894.57C737.56,-905.43 717.79,-922.04 700.68,-936.57 679.43,-954.61 654.09,-976.42 644.67,-984.54"/>
+</g>
+<!-- e_71_center -->
+<g id="node136" class="node">
+<title>e_71_center</title>
+<polygon fill="none" stroke="black" points="903.81,-788.09 896.81,-788.09 896.81,-781.09 903.81,-781.09 903.81,-788.09"/>
+</g>
+<!-- atp_c&#45;&gt;e_71_center -->
+<g id="edge257" class="edge">
+<title>atp_c&#45;&gt;e_71_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M779.27,-872.17C810.07,-849.88 879.64,-799.55 896.55,-787.31"/>
+</g>
+<!-- e_74_center -->
+<g id="node138" class="node">
+<title>e_74_center</title>
+<polygon fill="none" stroke="black" points="744.83,-694.55 737.83,-694.55 737.83,-687.55 744.83,-687.55 744.83,-694.55"/>
+</g>
+<!-- atp_c&#45;&gt;e_74_center -->
+<g id="edge267" class="edge">
+<title>atp_c&#45;&gt;e_74_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M766.97,-864.94C768.18,-854.1 769.22,-840.02 768.44,-827.52 765.1,-774 747.16,-710.68 742.46,-694.8"/>
+</g>
+<!-- e_79_center -->
+<g id="node142" class="node">
+<title>e_79_center</title>
+<polygon fill="none" stroke="black" points="983.88,-797.06 976.88,-797.06 976.88,-790.06 983.88,-790.06 983.88,-797.06"/>
+</g>
+<!-- atp_c&#45;&gt;e_79_center -->
+<g id="edge286" class="edge">
+<title>atp_c&#45;&gt;e_79_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M781.41,-875.87C827.54,-856.79 953.47,-804.69 976.68,-795.09"/>
+</g>
+<!-- e_80_center -->
+<g id="node143" class="node">
+<title>e_80_center</title>
+<polygon fill="none" stroke="black" points="918.47,-862.84 911.47,-862.84 911.47,-855.84 918.47,-855.84 918.47,-862.84"/>
+</g>
+<!-- atp_c&#45;&gt;e_80_center -->
+<g id="edge293" class="edge">
+<title>atp_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M782.33,-880.09C817.52,-874.58 893.95,-862.63 911.38,-859.9"/>
+</g>
+<!-- atp_c&#45;&gt;e_89_center -->
+<g id="edge326" class="edge">
+<title>atp_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M767.29,-901.02C776.23,-958.64 803.66,-1135.25 807.89,-1162.5"/>
+</g>
+<!-- adp_c -->
+<g id="node11" class="node">
+<title>adp_c</title>
+<ellipse fill="none" stroke="black" cx="802.41" cy="-929.72" rx="18" ry="18"/>
+<text text-anchor="middle" x="802.41" y="-926.02" font-family="Times,serif" font-size="14.00">adp_c</text>
+</g>
+<!-- e_11_center -->
+<g id="node35" class="node">
+<title>e_11_center</title>
+<polygon fill="none" stroke="black" points="852.21,-1118.11 845.21,-1118.11 845.21,-1111.11 852.21,-1111.11 852.21,-1118.11"/>
+</g>
+<!-- adp_c&#45;&gt;e_11_center -->
+<g id="edge46" class="edge">
+<title>adp_c&#45;&gt;e_11_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M805.35,-947.83C807.11,-958.02 809.51,-970.95 812.14,-982.36 824,-1033.9 842.79,-1095.5 847.58,-1110.96"/>
+</g>
+<!-- adp_c&#45;&gt;e_82_center -->
+<g id="edge302" class="edge">
+<title>adp_c&#45;&gt;e_82_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M819.86,-925.22C834.2,-921.59 855.06,-916.48 873.44,-912.64 912.97,-904.36 961.36,-896.58 974.86,-894.46"/>
+</g>
+<!-- actp_c -->
+<g id="node12" class="node">
+<title>actp_c</title>
+<ellipse fill="none" stroke="black" cx="476.98" cy="-1151.77" rx="18" ry="18"/>
+<text text-anchor="middle" x="476.98" y="-1148.07" font-family="Times,serif" font-size="14.00">actp_c</text>
+</g>
+<!-- e_2_center&#45;&gt;adp_c -->
+<g id="edge10" class="edge">
+<title>e_2_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M567.11,-1047.91C586.64,-1041.9 682.9,-1011.23 753.1,-969.39 762.87,-963.56 772.8,-955.97 781.16,-948.98"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="783.64,-951.46 788.94,-942.28 779.08,-946.15 783.64,-951.46"/>
+</g>
+<!-- e_2_center&#45;&gt;actp_c -->
+<g id="edge11" class="edge">
+<title>e_2_center&#45;&gt;actp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M560.29,-1052.88C549.79,-1065.34 516.57,-1104.78 495.39,-1129.92"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="492.48,-1127.94 488.71,-1137.84 497.83,-1132.45 492.48,-1127.94"/>
+</g>
+<!-- cit_c -->
+<g id="node14" class="node">
+<title>cit_c</title>
+<ellipse fill="none" stroke="black" cx="499.3" cy="-1028.97" rx="18" ry="18"/>
+<text text-anchor="middle" x="499.3" y="-1025.27" font-family="Times,serif" font-size="14.00">cit_c</text>
+</g>
+<!-- e_3_center -->
+<g id="node17" class="node">
+<title>e_3_center</title>
+<polygon fill="none" stroke="black" points="417.08,-914.83 410.08,-914.83 410.08,-907.83 417.08,-907.83 417.08,-914.83"/>
+</g>
+<!-- cit_c&#45;&gt;e_3_center -->
+<g id="edge12" class="edge">
+<title>cit_c&#45;&gt;e_3_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M488.44,-1014.07C468.44,-986.62 426.83,-929.51 416.13,-914.83"/>
+</g>
+<!-- h2o_c -->
+<g id="node15" class="node">
+<title>h2o_c</title>
+<ellipse fill="none" stroke="black" cx="739.36" cy="-955.4" rx="18" ry="18"/>
+<text text-anchor="middle" x="739.36" y="-951.7" font-family="Times,serif" font-size="14.00">h2o_c</text>
+</g>
+<!-- e_4_center -->
+<g id="node19" class="node">
+<title>e_4_center</title>
+<polygon fill="none" stroke="black" points="439.95,-982.98 432.95,-982.98 432.95,-975.98 439.95,-975.98 439.95,-982.98"/>
+</g>
+<!-- h2o_c&#45;&gt;e_4_center -->
+<g id="edge15" class="edge">
+<title>h2o_c&#45;&gt;e_4_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M721.32,-956.84C661.21,-961.62 469.83,-976.83 440.3,-979.18"/>
+</g>
+<!-- h2o_c&#45;&gt;e_10_center -->
+<g id="edge40" class="edge">
+<title>h2o_c&#45;&gt;e_10_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M739.71,-973.62C740.07,-981.96 740.79,-991.95 742.2,-1000.85 745.52,-1021.64 753.03,-1045.83 755.94,-1054.8"/>
+</g>
+<!-- h2o_c&#45;&gt;e_12_center -->
+<g id="edge58" class="edge">
+<title>h2o_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M752.79,-942.83C762.27,-934.41 775.56,-923.5 788.6,-915.81 842.97,-883.71 864.48,-892.8 921.67,-866.04 946.55,-854.4 974.52,-836.74 984.49,-830.29"/>
+</g>
+<!-- h2o_c&#45;&gt;e_14_center -->
+<g id="edge75" class="edge">
+<title>h2o_c&#45;&gt;e_14_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M754.27,-965.8C761.48,-971.42 769.83,-978.88 775.68,-987.03 796.79,-1016.42 804.21,-1061.32 806.02,-1074.63"/>
+</g>
+<!-- e_40_center -->
+<g id="node99" class="node">
+<title>e_40_center</title>
+<polygon fill="none" stroke="black" points="836.01,-709.7 829.01,-709.7 829.01,-702.7 836.01,-702.7 836.01,-709.7"/>
+</g>
+<!-- h2o_c&#45;&gt;e_40_center -->
+<g id="edge121" class="edge">
+<title>h2o_c&#45;&gt;e_40_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M750.42,-940.47C758.69,-928.91 769.96,-912.31 778.26,-896.81 815.47,-827.36 829.52,-729.64 832.06,-709.8"/>
+</g>
+<!-- e_45_center -->
+<g id="node107" class="node">
+<title>e_45_center</title>
+<polygon fill="none" stroke="black" points="836.29,-1310.83 829.29,-1310.83 829.29,-1303.83 836.29,-1303.83 836.29,-1310.83"/>
+</g>
+<!-- h2o_c&#45;&gt;e_45_center -->
+<g id="edge138" class="edge">
+<title>h2o_c&#45;&gt;e_45_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M739.14,-973.73C739.39,-982.1 740.18,-992.07 742.2,-1000.85 743.7,-1007.34 745.34,-1008.57 747.93,-1014.71 754.87,-1031.2 757.95,-1034.79 763.83,-1051.68 798.88,-1152.41 827.04,-1280.53 832.01,-1303.67"/>
+</g>
+<!-- h2o_c&#45;&gt;e_51_center -->
+<g id="edge167" class="edge">
+<title>h2o_c&#45;&gt;e_51_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M722.21,-961.04C698.41,-968.87 656.89,-982.53 644.49,-986.6"/>
+</g>
+<!-- e_52_center -->
+<g id="node117" class="node">
+<title>e_52_center</title>
+<polygon fill="none" stroke="black" points="883.64,-922.84 876.64,-922.84 876.64,-915.84 883.64,-915.84 883.64,-922.84"/>
+</g>
+<!-- h2o_c&#45;&gt;e_52_center -->
+<g id="edge174" class="edge">
+<title>h2o_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M757.49,-954.95C770.19,-954.32 787.48,-952.83 802.34,-949.32 831.92,-942.32 865.32,-926.63 876.37,-921.22"/>
+</g>
+<!-- e_53_center -->
+<g id="node118" class="node">
+<title>e_53_center</title>
+<polygon fill="none" stroke="black" points="590.47,-849.61 583.47,-849.61 583.47,-842.61 590.47,-842.61 590.47,-849.61"/>
+</g>
+<!-- h2o_c&#45;&gt;e_53_center -->
+<g id="edge181" class="edge">
+<title>h2o_c&#45;&gt;e_53_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M724.97,-944.59C721.42,-941.95 717.62,-939.14 714.08,-936.57 665.48,-901.17 605.58,-859.14 590.53,-848.6"/>
+</g>
+<!-- h2o_c&#45;&gt;e_61_center -->
+<g id="edge214" class="edge">
+<title>h2o_c&#45;&gt;e_61_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M754.18,-965.86C761.37,-971.5 769.73,-978.96 775.68,-987.03 828.36,-1058.46 855.18,-1167.24 860.09,-1188.59"/>
+</g>
+<!-- e_75_center -->
+<g id="node139" class="node">
+<title>e_75_center</title>
+<polygon fill="none" stroke="black" points="1093.25,-899.51 1086.25,-899.51 1086.25,-892.51 1093.25,-892.51 1093.25,-899.51"/>
+</g>
+<!-- h2o_c&#45;&gt;e_75_center -->
+<g id="edge271" class="edge">
+<title>h2o_c&#45;&gt;e_75_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M757.33,-954.09C769.96,-953.06 787.22,-951.45 802.34,-949.32 889.72,-936.98 910.77,-929.03 997.54,-912.97 1032.11,-906.58 1073.99,-898.9 1086.23,-896.66"/>
+</g>
+<!-- e_78_center -->
+<g id="node141" class="node">
+<title>e_78_center</title>
+<polygon fill="none" stroke="black" points="1007.74,-923.17 1000.74,-923.17 1000.74,-916.17 1007.74,-916.17 1007.74,-923.17"/>
+</g>
+<!-- h2o_c&#45;&gt;e_78_center -->
+<g id="edge280" class="edge">
+<title>h2o_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M757.31,-953.91C769.92,-952.8 787.18,-951.16 802.34,-949.32 882.88,-939.52 980.89,-923.53 1000.67,-920.27"/>
+</g>
+<!-- h2o_c&#45;&gt;e_80_center -->
+<g id="edge291" class="edge">
+<title>h2o_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M752.87,-942.95C762.39,-934.59 775.68,-923.7 788.6,-915.81 834.11,-887.98 895.72,-865.95 911.28,-860.59"/>
+</g>
+<!-- acon_C_c -->
+<g id="node16" class="node">
+<title>acon_C_c</title>
+<ellipse fill="none" stroke="black" cx="210.14" cy="-912.3" rx="18" ry="18"/>
+<text text-anchor="middle" x="210.14" y="-908.6" font-family="Times,serif" font-size="14.00">acon_C_c</text>
+</g>
+<!-- acon_C_c&#45;&gt;e_4_center -->
+<g id="edge16" class="edge">
+<title>acon_C_c&#45;&gt;e_4_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M225.9,-921.16C235.46,-926.41 247.96,-933.07 259.33,-938.43 324.42,-969.14 414.07,-977.71 432.9,-979.22"/>
+</g>
+<!-- e_3_center&#45;&gt;h2o_c -->
+<g id="edge13" class="edge">
+<title>e_3_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M417.24,-911.82C446.1,-915.73 637.82,-941.67 711.03,-951.57"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="710.95,-955.09 721.33,-952.96 711.89,-948.15 710.95,-955.09"/>
+</g>
+<!-- e_3_center&#45;&gt;acon_C_c -->
+<g id="edge14" class="edge">
+<title>e_3_center&#45;&gt;acon_C_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M409.68,-910.92C393.15,-909.25 327.34,-903.08 273.22,-904.98 261.74,-905.39 249.14,-906.68 238.25,-908.06"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="237.47,-904.64 228.03,-909.45 238.41,-911.57 237.47,-904.64"/>
+</g>
+<!-- icit_c -->
+<g id="node18" class="node">
+<title>icit_c</title>
+<ellipse fill="none" stroke="black" cx="634.63" cy="-1119.02" rx="18" ry="18"/>
+<text text-anchor="middle" x="634.63" y="-1115.32" font-family="Times,serif" font-size="14.00">icit_c</text>
+</g>
+<!-- e_58_center -->
+<g id="node124" class="node">
+<title>e_58_center</title>
+<polygon fill="none" stroke="black" points="987.48,-989.78 980.48,-989.78 980.48,-982.78 987.48,-982.78 987.48,-989.78"/>
+</g>
+<!-- icit_c&#45;&gt;e_58_center -->
+<g id="edge201" class="edge">
+<title>icit_c&#45;&gt;e_58_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M651.95,-1113.19C699.92,-1096.97 838.54,-1049.68 952.32,-1006.48 958.56,-1004.12 960.5,-1004.25 966.23,-1000.85 971.57,-997.67 976.99,-992.96 980.41,-989.76"/>
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+<!-- e_59_center -->
+<g id="node126" class="node">
+<title>e_59_center</title>
+<polygon fill="none" stroke="black" points="520.94,-1368.3 513.94,-1368.3 513.94,-1361.3 520.94,-1361.3 520.94,-1368.3"/>
+</g>
+<!-- icit_c&#45;&gt;e_59_center -->
+<g id="edge206" class="edge">
+<title>icit_c&#45;&gt;e_59_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M626.76,-1135.53C602.74,-1185.9 531.29,-1335.74 519.19,-1361.12"/>
+</g>
+<!-- e_4_center&#45;&gt;icit_c -->
+<g id="edge17" class="edge">
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+<!-- ac_e -->
+<g id="node20" class="node">
+<title>ac_e</title>
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+<text text-anchor="middle" x="416.75" y="-1679.41" font-family="Times,serif" font-size="14.00">ac_e</text>
+</g>
+<!-- e_5_center -->
+<g id="node22" class="node">
+<title>e_5_center</title>
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+<!-- ac_e&#45;&gt;e_5_center -->
+<g id="edge18" class="edge">
+<title>ac_e&#45;&gt;e_5_center</title>
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+</g>
+<!-- e_19_target -->
+<g id="node63" class="node">
+<title>e_19_target</title>
+<ellipse fill="black" stroke="black" cx="227.74" cy="-1865.27" rx="1.8" ry="1.8"/>
+</g>
+<!-- ac_e&#45;&gt;e_19_target -->
+<g id="edge98" class="edge">
+<title>ac_e&#45;&gt;e_19_target</title>
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+<!-- h_e -->
+<g id="node21" class="node">
+<title>h_e</title>
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+</g>
+<!-- h_e&#45;&gt;e_5_center -->
+<g id="edge19" class="edge">
+<title>h_e&#45;&gt;e_5_center</title>
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+</g>
+<!-- e_8_center -->
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+<!-- h_e&#45;&gt;e_8_center -->
+<g id="edge31" class="edge">
+<title>h_e&#45;&gt;e_8_center</title>
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+</g>
+<!-- h_e&#45;&gt;e_11_center -->
+<g id="edge47" class="edge">
+<title>h_e&#45;&gt;e_11_center</title>
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+<!-- e_16_center -->
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+<!-- h_e&#45;&gt;e_16_center -->
+<g id="edge87" class="edge">
+<title>h_e&#45;&gt;e_16_center</title>
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+<!-- e_18_center -->
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+<!-- h_e&#45;&gt;e_18_center -->
+<g id="edge94" class="edge">
+<title>h_e&#45;&gt;e_18_center</title>
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+<!-- e_30_target -->
+<g id="node80" class="node">
+<title>e_30_target</title>
+<ellipse fill="black" stroke="black" cx="1050.19" cy="-1667.04" rx="1.8" ry="1.8"/>
+</g>
+<!-- h_e&#45;&gt;e_30_target -->
+<g id="edge109" class="edge">
+<title>h_e&#45;&gt;e_30_target</title>
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+<!-- e_41_center -->
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+<title>e_41_center</title>
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+<!-- h_e&#45;&gt;e_41_center -->
+<g id="edge126" class="edge">
+<title>h_e&#45;&gt;e_41_center</title>
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+<!-- e_46_center -->
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+<!-- h_e&#45;&gt;e_46_center -->
+<g id="edge141" class="edge">
+<title>h_e&#45;&gt;e_46_center</title>
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+<!-- e_55_center -->
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+<!-- h_e&#45;&gt;e_55_center -->
+<g id="edge191" class="edge">
+<title>h_e&#45;&gt;e_55_center</title>
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+<!-- e_62_center -->
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+<!-- h_e&#45;&gt;e_62_center -->
+<g id="edge220" class="edge">
+<title>h_e&#45;&gt;e_62_center</title>
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+<!-- e_77_center -->
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+<!-- h_e&#45;&gt;e_77_center -->
+<g id="edge276" class="edge">
+<title>h_e&#45;&gt;e_77_center</title>
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+<!-- e_83_center -->
+<g id="node146" class="node">
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+<!-- h_e&#45;&gt;e_83_center -->
+<g id="edge307" class="edge">
+<title>h_e&#45;&gt;e_83_center</title>
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+</g>
+<!-- e_86_center -->
+<g id="node148" class="node">
+<title>e_86_center</title>
+<polygon fill="none" stroke="black" points="908.34,-1524.24 901.34,-1524.24 901.34,-1517.24 908.34,-1517.24 908.34,-1524.24"/>
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+<!-- h_e&#45;&gt;e_86_center -->
+<g id="edge314" class="edge">
+<title>h_e&#45;&gt;e_86_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M981.57,-1404.01C961.65,-1434.32 917.85,-1500.96 907.21,-1517.14"/>
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+<!-- e_87_center -->
+<g id="node149" class="node">
+<title>e_87_center</title>
+<polygon fill="none" stroke="black" points="880.82,-1511.72 873.82,-1511.72 873.82,-1504.72 880.82,-1504.72 880.82,-1511.72"/>
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+<!-- h_e&#45;&gt;e_87_center -->
+<g id="edge317" class="edge">
+<title>h_e&#45;&gt;e_87_center</title>
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+</g>
+<!-- h_e&#45;&gt;e_91_center -->
+<g id="edge336" class="edge">
+<title>h_e&#45;&gt;e_91_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M999.68,-1372.66C1025.01,-1322.36 1101.28,-1170.93 1114.2,-1145.27"/>
+</g>
+<!-- e_5_center&#45;&gt;h_c -->
+<g id="edge21" class="edge">
+<title>e_5_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M690.22,-1429.65C700.12,-1424.07 727.53,-1408.24 748.65,-1392.59 832.48,-1330.5 922.1,-1244.38 961.07,-1205.82"/>
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+</g>
+<!-- e_5_center&#45;&gt;ac_c -->
+<g id="edge20" class="edge">
+<title>e_5_center&#45;&gt;ac_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M682.59,-1429.26C659.64,-1414.37 540.06,-1336.79 488.42,-1303.29"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="490.18,-1300.26 479.89,-1297.75 486.37,-1306.13 490.18,-1300.26"/>
+</g>
+<!-- amp_c -->
+<g id="node23" class="node">
+<title>amp_c</title>
+<ellipse fill="none" stroke="black" cx="698.26" cy="-637.56" rx="18" ry="18"/>
+<text text-anchor="middle" x="698.26" y="-633.86" font-family="Times,serif" font-size="14.00">amp_c</text>
+</g>
+<!-- amp_c&#45;&gt;e_6_center -->
+<g id="edge22" class="edge">
+<title>amp_c&#45;&gt;e_6_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M688.82,-653.04C673.31,-678.5 643.28,-727.76 634.71,-741.82"/>
+</g>
+<!-- e_6_center&#45;&gt;adp_c -->
+<g id="edge24" class="edge">
+<title>e_6_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M634.57,-749.3C645.39,-767.12 694.83,-846.1 750.54,-896.67 758.52,-903.91 768.27,-910.58 777.16,-916"/>
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+<!-- akg_c -->
+<g id="node25" class="node">
+<title>akg_c</title>
+<ellipse fill="none" stroke="black" cx="1069.22" cy="-1067.79" rx="18" ry="18"/>
+<text text-anchor="middle" x="1069.22" y="-1064.09" font-family="Times,serif" font-size="14.00">akg_c</text>
+</g>
+<!-- akg_c&#45;&gt;e_7_center -->
+<g id="edge26" class="edge">
+<title>akg_c&#45;&gt;e_7_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1087.21,-1068.96C1097.32,-1069.82 1110.13,-1071.25 1121.38,-1073.52 1125.33,-1074.32 1182.71,-1091.67 1197.88,-1096.27"/>
+</g>
+<!-- akg_c&#45;&gt;e_54_center -->
+<g id="edge185" class="edge">
+<title>akg_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1054.01,-1058.15C1034.42,-1045.17 1000.17,-1020.51 977.28,-992.98 970.85,-985.25 973.21,-980.55 966.44,-973.13 960.53,-966.67 951.5,-961.55 946.43,-958.99"/>
+</g>
+<!-- co2_c -->
+<g id="node26" class="node">
+<title>co2_c</title>
+<ellipse fill="none" stroke="black" cx="1257.36" cy="-864.4" rx="18" ry="18"/>
+<text text-anchor="middle" x="1257.36" y="-860.7" font-family="Times,serif" font-size="14.00">co2_c</text>
+</g>
+<!-- co2_c&#45;&gt;e_78_center -->
+<g id="edge281" class="edge">
+<title>co2_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1239.49,-860.46C1230.09,-858.91 1218.38,-857.83 1207.97,-859.31 1169.3,-864.83 1166,-885.88 1128.52,-896.88 1081.79,-910.6 1022.65,-917.67 1007.76,-919.3"/>
+</g>
+<!-- succoa_c -->
+<g id="node27" class="node">
+<title>succoa_c</title>
+<ellipse fill="none" stroke="black" cx="1023.77" cy="-1259.8" rx="18" ry="18"/>
+<text text-anchor="middle" x="1023.77" y="-1256.1" font-family="Times,serif" font-size="14.00">succoa_c</text>
+</g>
+<!-- e_7_center&#45;&gt;nadh_c -->
+<g id="edge30" class="edge">
+<title>e_7_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1197.94,-1094.32C1195.21,-1092.01 1191.22,-1088.63 1186.96,-1085.01"/>
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+<!-- e_7_center&#45;&gt;co2_c -->
+<g id="edge28" class="edge">
+<title>e_7_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1202.41,-1093.72C1207.87,-1070.93 1237.41,-947.64 1250.78,-891.85"/>
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+<!-- e_7_center&#45;&gt;succoa_c -->
+<g id="edge29" class="edge">
+<title>e_7_center&#45;&gt;succoa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1197.82,-1100.77C1178.24,-1118.66 1086.31,-1202.65 1044.53,-1240.83"/>
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+<!-- akg_e -->
+<g id="node29" class="node">
+<title>akg_e</title>
+<ellipse fill="none" stroke="black" cx="1460.4" cy="-1630.69" rx="18" ry="18"/>
+<text text-anchor="middle" x="1460.4" y="-1626.99" font-family="Times,serif" font-size="14.00">akg_e</text>
+</g>
+<!-- akg_e&#45;&gt;e_8_center -->
+<g id="edge32" class="edge">
+<title>akg_e&#45;&gt;e_8_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1446.27,-1618.85C1425.54,-1601.34 1385.86,-1567.28 1353.75,-1536.54 1290.47,-1475.96 1218.19,-1397.04 1202.11,-1379.38"/>
+</g>
+<!-- e_21_target -->
+<g id="node65" class="node">
+<title>e_21_target</title>
+<ellipse fill="black" stroke="black" cx="1658.89" cy="-1816.17" rx="1.8" ry="1.8"/>
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+<!-- akg_e&#45;&gt;e_21_target -->
+<g id="edge100" class="edge">
+<title>akg_e&#45;&gt;e_21_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1473.73,-1643.15C1511.38,-1678.33 1617.84,-1777.81 1649.75,-1807.62"/>
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+<!-- e_8_center&#45;&gt;h_c -->
+<g id="edge34" class="edge">
+<title>e_8_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1195.06,-1372.47C1172.21,-1352.53 1051.91,-1247.56 1002.39,-1204.36"/>
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+<!-- e_8_center&#45;&gt;akg_c -->
+<g id="edge33" class="edge">
+<title>e_8_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1197.2,-1371.87C1185.08,-1343.07 1109,-1162.32 1080.23,-1093.95"/>
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+<!-- etoh_c -->
+<g id="node31" class="node">
+<title>etoh_c</title>
+<ellipse fill="none" stroke="black" cx="1367.72" cy="-1522.79" rx="18" ry="18"/>
+<text text-anchor="middle" x="1367.72" y="-1519.09" font-family="Times,serif" font-size="14.00">etoh_c</text>
+</g>
+<!-- etoh_c&#45;&gt;e_9_center -->
+<g id="edge36" class="edge">
+<title>etoh_c&#45;&gt;e_9_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1361.81,-1505.78C1344.06,-1454.66 1291.9,-1304.4 1283.06,-1278.96"/>
+</g>
+<!-- e_9_center&#45;&gt;acald_c -->
+<g id="edge37" class="edge">
+<title>e_9_center&#45;&gt;acald_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1285.68,-1275.97C1312.04,-1280.66 1465.07,-1307.91 1529.21,-1319.32"/>
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+<!-- e_9_center&#45;&gt;h_c -->
+<g id="edge39" class="edge">
+<title>e_9_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1277.98,-1274.14C1250.1,-1265.84 1076.43,-1214.14 1008.38,-1193.88"/>
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+<!-- e_9_center&#45;&gt;nadh_c -->
+<g id="edge38" class="edge">
+<title>e_9_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1279.76,-1271.65C1267.91,-1250.41 1206.95,-1141.19 1179.18,-1091.44"/>
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+<!-- pi_c -->
+<g id="node33" class="node">
+<title>pi_c</title>
+<ellipse fill="none" stroke="black" cx="831.73" cy="-982.39" rx="18" ry="18"/>
+<text text-anchor="middle" x="831.73" y="-978.69" font-family="Times,serif" font-size="14.00">pi_c</text>
+</g>
+<!-- pi_c&#45;&gt;e_11_center -->
+<g id="edge45" class="edge">
+<title>pi_c&#45;&gt;e_11_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M834.06,-1000.49C838.09,-1031.9 846.15,-1094.65 848.22,-1110.77"/>
+</g>
+<!-- pi_c&#45;&gt;e_48_center -->
+<g id="edge150" class="edge">
+<title>pi_c&#45;&gt;e_48_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M846.76,-971.79C887.48,-943.05 998.37,-864.8 1019.64,-849.79"/>
+</g>
+<!-- pi_c&#45;&gt;e_81_center -->
+<g id="edge298" class="edge">
+<title>pi_c&#45;&gt;e_81_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M823.63,-998.48C807.19,-1031.13 770.71,-1103.58 761.84,-1121.18"/>
+</g>
+<!-- e_10_center&#45;&gt;h_c -->
+<g id="edge44" class="edge">
+<title>e_10_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M761,-1061.13C768.33,-1066.27 784.85,-1077.51 799.79,-1085.18 823.55,-1097.38 831.62,-1095.79 855.41,-1107.91 892.47,-1126.8 932.98,-1152.98 957.71,-1169.64"/>
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+</g>
+<!-- e_10_center&#45;&gt;adp_c -->
+<g id="edge43" class="edge">
+<title>e_10_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M758.68,-1054.77C761.87,-1047.3 769.4,-1029.62 775.65,-1014.75 778.23,-1008.6 779.18,-1007.18 781.4,-1000.9 786.46,-986.62 791.31,-970.44 795.06,-957.12"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="799.37,-957.95 797.83,-947.14 790.94,-955.61 799.37,-957.95"/>
+</g>
+<!-- e_10_center&#45;&gt;pi_c -->
+<g id="edge42" class="edge">
+<title>e_10_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M760.73,-1054.72C769.8,-1045.48 794.11,-1020.71 811.77,-1002.73"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="814.98,-1005.7 818.86,-995.5 808.73,-999.57 814.98,-1005.7"/>
+</g>
+<!-- e_11_center&#45;&gt;h_c -->
+<g id="edge50" class="edge">
+<title>e_11_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M852.25,-1116.51C866.77,-1124.32 922.54,-1154.29 955.75,-1172.15"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="954.4,-1175.39 964.87,-1177.04 957.72,-1169.23 954.4,-1175.39"/>
+</g>
+<!-- e_11_center&#45;&gt;atp_c -->
+<g id="edge49" class="edge">
+<title>e_11_center&#45;&gt;atp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M847.39,-1110.97C839.11,-1088.2 794.17,-964.57 774.13,-909.44"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="777.4,-908.19 770.69,-899.98 770.82,-910.58 777.4,-908.19"/>
+</g>
+<!-- e_11_center&#45;&gt;h2o_c -->
+<g id="edge48" class="edge">
+<title>e_11_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M847.09,-1110.78C840.15,-1094.61 811.62,-1030.83 775.68,-987.03 771.6,-982.06 766.7,-977.22 761.84,-972.89"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="763.73,-969.91 753.83,-966.13 759.22,-975.26 763.73,-969.91"/>
+</g>
+<!-- gln__L_c -->
+<g id="node36" class="node">
+<title>gln__L_c</title>
+<ellipse fill="none" stroke="black" cx="748.84" cy="-827.41" rx="18" ry="18"/>
+<text text-anchor="middle" x="748.84" y="-823.71" font-family="Times,serif" font-size="14.00">gln__L_c</text>
+</g>
+<!-- gln__L_c&#45;&gt;e_12_center -->
+<g id="edge51" class="edge">
+<title>gln__L_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M767.23,-827.44C818.26,-827.53 959.51,-827.77 984.48,-827.81"/>
+</g>
+<!-- gln__L_c&#45;&gt;e_53_center -->
+<g id="edge182" class="edge">
+<title>gln__L_c&#45;&gt;e_53_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M730.9,-829.49C693.69,-833.78 610.01,-843.45 590.91,-845.66"/>
+</g>
+<!-- gln__L_c&#45;&gt;e_54_center -->
+<g id="edge187" class="edge">
+<title>gln__L_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M764.54,-836.28C790.57,-851.16 844.01,-882.49 886.84,-912.64 907.31,-927.05 930.22,-946.45 938.97,-954"/>
+</g>
+<!-- 3pg_c -->
+<g id="node37" class="node">
+<title>3pg_c</title>
+<ellipse fill="none" stroke="black" cx="815.53" cy="-556.84" rx="18" ry="18"/>
+<text text-anchor="middle" x="815.53" y="-553.14" font-family="Times,serif" font-size="14.00">3pg_c</text>
+</g>
+<!-- 3pg_c&#45;&gt;e_12_center -->
+<g id="edge52" class="edge">
+<title>3pg_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M825.31,-572.18C858.86,-624.81 968.14,-796.23 985.84,-824"/>
+</g>
+<!-- 3pg_c&#45;&gt;e_74_center -->
+<g id="edge268" class="edge">
+<title>3pg_c&#45;&gt;e_74_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M806.73,-572.76C789.53,-603.87 752.36,-671.11 743.33,-687.43"/>
+</g>
+<!-- f6p_c -->
+<g id="node38" class="node">
+<title>f6p_c</title>
+<ellipse fill="none" stroke="black" cx="1038.14" cy="-546.2" rx="18" ry="18"/>
+<text text-anchor="middle" x="1038.14" y="-542.5" font-family="Times,serif" font-size="14.00">f6p_c</text>
+</g>
+<!-- f6p_c&#45;&gt;e_12_center -->
+<g id="edge53" class="edge">
+<title>f6p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1034.94,-564.24C1024.8,-621.54 993.7,-797.19 988.9,-824.29"/>
+</g>
+<!-- f6p_c&#45;&gt;e_71_center -->
+<g id="edge258" class="edge">
+<title>f6p_c&#45;&gt;e_71_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M1029.09,-561.84C1001.06,-610.32 916.67,-756.28 902.38,-781.01"/>
+</g>
+<!-- pyr_c -->
+<g id="node39" class="node">
+<title>pyr_c</title>
+<ellipse fill="none" stroke="black" cx="1207.84" cy="-878.91" rx="18" ry="18"/>
+<text text-anchor="middle" x="1207.84" y="-875.21" font-family="Times,serif" font-size="14.00">pyr_c</text>
+</g>
+<!-- pyr_c&#45;&gt;e_12_center -->
+<g id="edge54" class="edge">
+<title>pyr_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1190.29,-873.93C1174.28,-869.45 1149.95,-862.8 1128.63,-857.68 1074.85,-844.76 1008.8,-831.79 992.2,-828.57"/>
+</g>
+<!-- pyr_c&#45;&gt;e_70_center -->
+<g id="edge252" class="edge">
+<title>pyr_c&#45;&gt;e_70_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1210.23,-897.07C1210.72,-901.54 1211.17,-906.31 1211.41,-910.76 1213.22,-942.96 1202.52,-981.25 1198.96,-992.95"/>
+</g>
+<!-- pyr_c&#45;&gt;e_72_center -->
+<g id="edge263" class="edge">
+<title>pyr_c&#45;&gt;e_72_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1213.13,-896.28C1228.55,-946.89 1272.84,-1092.24 1280.34,-1116.84"/>
+</g>
+<!-- pyr_c&#45;&gt;e_80_center -->
+<g id="edge292" class="edge">
+<title>pyr_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1190.8,-872.91C1174.94,-867.67 1150.52,-860.48 1128.63,-857.68 1085.58,-852.18 942.71,-858.12 918.48,-859.18"/>
+</g>
+<!-- r5p_c -->
+<g id="node40" class="node">
+<title>r5p_c</title>
+<ellipse fill="none" stroke="black" cx="1123.47" cy="-472.63" rx="18" ry="18"/>
+<text text-anchor="middle" x="1123.47" y="-468.93" font-family="Times,serif" font-size="14.00">r5p_c</text>
+</g>
+<!-- r5p_c&#45;&gt;e_12_center -->
+<g id="edge56" class="edge">
+<title>r5p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1116.95,-489.76C1091.85,-555.72 1002.2,-791.22 989.72,-824.01"/>
+</g>
+<!-- ru5p__D_c -->
+<g id="node122" class="node">
+<title>ru5p__D_c</title>
+<ellipse fill="none" stroke="black" cx="1303.98" cy="-377.26" rx="18" ry="18"/>
+<text text-anchor="middle" x="1303.98" y="-373.56" font-family="Times,serif" font-size="14.00">ru5p__D_c</text>
+</g>
+<!-- r5p_c&#45;&gt;ru5p__D_c -->
+<g id="edge312" class="edge">
+<title>r5p_c&#45;&gt;ru5p__D_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1139.49,-464.16C1170.94,-447.55 1240.95,-410.56 1278.7,-390.62"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1280.79,-393.47 1288,-385.71 1277.52,-387.29 1280.79,-393.47"/>
+</g>
+<!-- e_92_center -->
+<g id="node155" class="node">
+<title>e_92_center</title>
+<polygon fill="none" stroke="black" points="1120.35,-228.53 1113.35,-228.53 1113.35,-221.53 1120.35,-221.53 1120.35,-228.53"/>
+</g>
+<!-- r5p_c&#45;&gt;e_92_center -->
+<g id="edge342" class="edge">
+<title>r5p_c&#45;&gt;e_92_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1123.76,-454.27C1124.14,-423.75 1124.57,-360.65 1122.57,-307.31 1121.43,-276.97 1118.26,-240.45 1117.2,-228.79"/>
+</g>
+<!-- e4p_c -->
+<g id="node41" class="node">
+<title>e4p_c</title>
+<ellipse fill="none" stroke="black" cx="1053.21" cy="-471.31" rx="18" ry="18"/>
+<text text-anchor="middle" x="1053.21" y="-467.61" font-family="Times,serif" font-size="14.00">e4p_c</text>
+</g>
+<!-- e4p_c&#45;&gt;e_12_center -->
+<g id="edge57" class="edge">
+<title>e4p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1055.8,-489.2C1057.65,-504.4 1059.51,-526.78 1057.74,-546.26 1047.11,-663.08 998.29,-800.49 989.6,-824.23"/>
+</g>
+<!-- e_93_center -->
+<g id="node156" class="node">
+<title>e_93_center</title>
+<polygon fill="none" stroke="black" points="1119.37,-317.51 1112.37,-317.51 1112.37,-310.51 1119.37,-310.51 1119.37,-317.51"/>
+</g>
+<!-- e4p_c&#45;&gt;e_93_center -->
+<g id="edge345" class="edge">
+<title>e4p_c&#45;&gt;e_93_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1059.91,-454.47C1074.18,-418.65 1106.87,-336.6 1114.33,-317.87"/>
+</g>
+<!-- g3p_c -->
+<g id="node42" class="node">
+<title>g3p_c</title>
+<ellipse fill="none" stroke="black" cx="1005.27" cy="-459.71" rx="18" ry="18"/>
+<text text-anchor="middle" x="1005.27" y="-456.01" font-family="Times,serif" font-size="14.00">g3p_c</text>
+</g>
+<!-- g3p_c&#45;&gt;e_12_center -->
+<g id="edge59" class="edge">
+<title>g3p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1004.44,-477.71C1001.25,-546.71 989.93,-792.02 988.44,-824.3"/>
+</g>
+<!-- g3p_c&#45;&gt;e_48_center -->
+<g id="edge152" class="edge">
+<title>g3p_c&#45;&gt;e_48_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1006.11,-477.88C1009.42,-549.42 1021.44,-809.35 1023.02,-843.56"/>
+</g>
+<!-- e_90_center -->
+<g id="node153" class="node">
+<title>e_90_center</title>
+<polygon fill="none" stroke="black" points="1050.03,-283.06 1043.03,-283.06 1043.03,-276.06 1050.03,-276.06 1050.03,-283.06"/>
+</g>
+<!-- g3p_c&#45;&gt;e_90_center -->
+<g id="edge332" class="edge">
+<title>g3p_c&#45;&gt;e_90_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1009.3,-442.11C1018.59,-401.56 1041.05,-303.48 1045.68,-283.25"/>
+</g>
+<!-- g6p_c -->
+<g id="node43" class="node">
+<title>g6p_c</title>
+<ellipse fill="none" stroke="black" cx="1195.72" cy="-670.74" rx="18" ry="18"/>
+<text text-anchor="middle" x="1195.72" y="-667.04" font-family="Times,serif" font-size="14.00">g6p_c</text>
+</g>
+<!-- g6p_c&#45;&gt;f6p_c -->
+<g id="edge266" class="edge">
+<title>g6p_c&#45;&gt;f6p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M1181.45,-659.47C1154.05,-637.81 1093.85,-590.23 1060.86,-564.15"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.4" points="1062.94,-560.89 1052.71,-557.71 1058.17,-566.93 1062.94,-560.89"/>
+</g>
+<!-- g6p_c&#45;&gt;e_12_center -->
+<g id="edge60" class="edge">
+<title>g6p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1181.13,-681.78C1138.34,-714.19 1014.72,-807.79 991.92,-825.06"/>
+</g>
+<!-- e_47_center -->
+<g id="node110" class="node">
+<title>e_47_center</title>
+<polygon fill="none" stroke="black" points="1208.21,-920.96 1201.21,-920.96 1201.21,-913.96 1208.21,-913.96 1208.21,-920.96"/>
+</g>
+<!-- g6p_c&#45;&gt;e_47_center -->
+<g id="edge146" class="edge">
+<title>g6p_c&#45;&gt;e_47_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1192.55,-688.72C1186.73,-725 1175.97,-809.38 1188.24,-878.78 1190.63,-892.29 1198.39,-906.82 1202.35,-913.58"/>
+</g>
+<!-- pep_c -->
+<g id="node44" class="node">
+<title>pep_c</title>
+<ellipse fill="none" stroke="black" cx="1071.25" cy="-682.94" rx="18" ry="18"/>
+<text text-anchor="middle" x="1071.25" y="-679.24" font-family="Times,serif" font-size="14.00">pep_c</text>
+</g>
+<!-- pep_c&#45;&gt;e_12_center -->
+<g id="edge62" class="edge">
+<title>pep_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1062.21,-698.72C1043.22,-731.87 1000.14,-807.1 990.3,-824.28"/>
+</g>
+<!-- e_44_center -->
+<g id="node105" class="node">
+<title>e_44_center</title>
+<polygon fill="none" stroke="black" points="1274.78,-525.21 1267.78,-525.21 1267.78,-518.21 1274.78,-518.21 1274.78,-525.21"/>
+</g>
+<!-- pep_c&#45;&gt;e_44_center -->
+<g id="edge135" class="edge">
+<title>pep_c&#45;&gt;e_44_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1085.31,-671.6C1126.57,-638.34 1245.78,-542.26 1267.77,-524.53"/>
+</g>
+<!-- e_49_center -->
+<g id="node113" class="node">
+<title>e_49_center</title>
+<polygon fill="none" stroke="black" points="1359.54,-592.38 1352.54,-592.38 1352.54,-585.38 1359.54,-585.38 1359.54,-592.38"/>
+</g>
+<!-- pep_c&#45;&gt;e_49_center -->
+<g id="edge157" class="edge">
+<title>pep_c&#45;&gt;e_49_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M1088.63,-677.19C1145.63,-658.37 1324.79,-599.2 1352.44,-590.07"/>
+</g>
+<!-- pep_c&#45;&gt;e_78_center -->
+<g id="edge282" class="edge">
+<title>pep_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1067.79,-700.63C1061.5,-731.92 1047.22,-798.9 1029.89,-853.99 1022.25,-878.28 1010.09,-906.46 1005.8,-916.17"/>
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+<!-- pep_c&#45;&gt;e_82_center -->
+<g id="edge303" class="edge">
+<title>pep_c&#45;&gt;e_82_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M1063.97,-699.49C1044.15,-744.56 990.06,-867.6 980.09,-890.27"/>
+</g>
+<!-- oaa_c -->
+<g id="node45" class="node">
+<title>oaa_c</title>
+<ellipse fill="none" stroke="black" cx="952.47" cy="-986.88" rx="18" ry="18"/>
+<text text-anchor="middle" x="952.47" y="-983.18" font-family="Times,serif" font-size="14.00">oaa_c</text>
+</g>
+<!-- oaa_c&#45;&gt;e_12_center -->
+<g id="edge63" class="edge">
+<title>oaa_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M955.54,-968.78C959.04,-948.73 965.14,-915.5 971.8,-887.19 976.8,-865.94 984.29,-840.86 987.13,-831.54"/>
+</g>
+<!-- oaa_c&#45;&gt;e_14_center -->
+<g id="edge77" class="edge">
+<title>oaa_c&#45;&gt;e_14_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M937.13,-996.51C904.04,-1017.27 827.56,-1065.26 810.09,-1076.22"/>
+</g>
+<!-- oaa_c&#45;&gt;e_79_center -->
+<g id="edge287" class="edge">
+<title>oaa_c&#45;&gt;e_79_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M955.05,-969.04C961.25,-926.04 976.76,-818.66 979.84,-797.29"/>
+</g>
+<!-- nadph_c -->
+<g id="node46" class="node">
+<title>nadph_c</title>
+<ellipse fill="none" stroke="black" cx="1130.02" cy="-921.3" rx="18" ry="18"/>
+<text text-anchor="middle" x="1130.02" y="-917.6" font-family="Times,serif" font-size="14.00">nadph_c</text>
+</g>
+<!-- nadph_c&#45;&gt;e_12_center -->
+<g id="edge65" class="edge">
+<title>nadph_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1112.58,-915.6C1103.52,-912.34 1092.42,-907.88 1083.05,-902.71 1043.76,-881.02 1003.93,-843.26 991.92,-831.45"/>
+</g>
+<!-- nadph_c&#45;&gt;e_54_center -->
+<g id="edge188" class="edge">
+<title>nadph_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1112.05,-924.74C1069.92,-932.81 966.75,-952.57 946.23,-956.5"/>
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+<!-- nadph_c&#45;&gt;e_67_center -->
+<g id="edge246" class="edge">
+<title>nadph_c&#45;&gt;e_67_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1147.67,-924.84C1186.07,-932.54 1275.28,-950.44 1294.34,-954.26"/>
+</g>
+<!-- glu__L_c -->
+<g id="node47" class="node">
+<title>glu__L_c</title>
+<ellipse fill="none" stroke="black" cx="761.8" cy="-1000.87" rx="18" ry="18"/>
+<text text-anchor="middle" x="761.8" y="-997.17" font-family="Times,serif" font-size="14.00">glu__L_c</text>
+</g>
+<!-- glu__L_c&#45;&gt;e_12_center -->
+<g id="edge66" class="edge">
+<title>glu__L_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M776.14,-989.3C797.27,-972.29 838.1,-939.64 873.44,-912.64 916.76,-879.53 970.43,-840.68 984.67,-830.41"/>
+</g>
+<!-- glu__L_c&#45;&gt;e_50_center -->
+<g id="edge162" class="edge">
+<title>glu__L_c&#45;&gt;e_50_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M747.22,-989.57C740.24,-983.83 731.99,-976.51 725.38,-969.14 718.81,-961.81 712.58,-951.99 709.46,-946.81"/>
+</g>
+<!-- glu__L_c&#45;&gt;e_52_center -->
+<g id="edge176" class="edge">
+<title>glu__L_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M776.79,-990.55C804.4,-971.52 861.84,-931.94 876.61,-921.77"/>
+</g>
+<!-- nadp_c -->
+<g id="node48" class="node">
+<title>nadp_c</title>
+<ellipse fill="none" stroke="black" cx="1128.57" cy="-877.28" rx="18" ry="18"/>
+<text text-anchor="middle" x="1128.57" y="-873.58" font-family="Times,serif" font-size="14.00">nadp_c</text>
+</g>
+<!-- nadp_c&#45;&gt;e_47_center -->
+<g id="edge145" class="edge">
+<title>nadp_c&#45;&gt;e_47_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1144.72,-885.8C1162.88,-895.38 1191.14,-910.29 1201.09,-915.54"/>
+</g>
+<!-- nadp_c&#45;&gt;e_52_center -->
+<g id="edge175" class="edge">
+<title>nadp_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1110.71,-880.31C1058.64,-889.12 909.11,-914.43 883.8,-918.72"/>
+</g>
+<!-- e_56_center -->
+<g id="node123" class="node">
+<title>e_56_center</title>
+<polygon fill="none" stroke="black" points="1270.63,-674.19 1263.63,-674.19 1263.63,-667.19 1270.63,-667.19 1270.63,-674.19"/>
+</g>
+<!-- nadp_c&#45;&gt;e_56_center -->
+<g id="edge196" class="edge">
+<title>nadp_c&#45;&gt;e_56_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1138.76,-862.09C1167.76,-818.85 1249.63,-696.79 1264.72,-674.28"/>
+</g>
+<!-- nadp_c&#45;&gt;e_58_center -->
+<g id="edge202" class="edge">
+<title>nadp_c&#45;&gt;e_58_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1114.26,-888.77C1108.72,-893.17 1102.32,-898.21 1096.45,-902.71 1053.99,-935.28 1001.44,-973.59 987.5,-983.72"/>
+</g>
+<!-- e_65_center -->
+<g id="node132" class="node">
+<title>e_65_center</title>
+<polygon fill="none" stroke="black" points="1260.89,-1014.85 1253.89,-1014.85 1253.89,-1007.85 1260.89,-1007.85 1260.89,-1014.85"/>
+</g>
+<!-- nadp_c&#45;&gt;e_65_center -->
+<g id="edge234" class="edge">
+<title>nadp_c&#45;&gt;e_65_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1141.4,-890.63C1169.91,-920.3 1237.33,-990.48 1253.74,-1007.56"/>
+</g>
+<!-- nadp_c&#45;&gt;e_91_center -->
+<g id="edge335" class="edge">
+<title>nadp_c&#45;&gt;e_91_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1120.3,-893.49C1116.58,-901.58 1112.56,-911.63 1110.42,-921.11 1093.59,-995.72 1092.58,-1017.04 1101.65,-1092.99 1103.69,-1110.11 1111.06,-1129.48 1114.4,-1137.63"/>
+</g>
+<!-- e_12_center&#45;&gt;coa_c -->
+<g id="edge67" class="edge">
+<title>e_12_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M988.24,-831.43C988.1,-853.22 988.11,-969.33 1003.27,-1062.35 1004.16,-1067.79 1005.43,-1073.53 1006.81,-1079.01"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1003.54,-1080.32 1009.52,-1089.06 1010.3,-1078.5 1003.54,-1080.32"/>
+</g>
+<!-- e_12_center&#45;&gt;h_c -->
+<g id="edge73" class="edge">
+<title>e_12_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M988.36,-831.57C988.72,-848.63 990.21,-920.56 990.68,-979.58 991.18,-1043.26 986.35,-1117.88 983.36,-1157.56"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="979.86,-1157.32 982.58,-1167.56 986.84,-1157.86 979.86,-1157.32"/>
+</g>
+<!-- e_12_center&#45;&gt;nadh_c -->
+<g id="edge69" class="edge">
+<title>e_12_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M991.06,-831.57C1008.94,-855.69 1108.25,-989.65 1148.46,-1043.89"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1145.84,-1046.23 1154.61,-1052.18 1151.46,-1042.06 1145.84,-1046.23"/>
+</g>
+<!-- e_12_center&#45;&gt;adp_c -->
+<g id="edge71" class="edge">
+<title>e_12_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M984.69,-829.93C974.74,-835.77 945.93,-852.61 921.67,-866.04 889.4,-883.91 851.81,-903.83 827.59,-916.56"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="825.93,-913.48 818.7,-921.22 829.18,-919.68 825.93,-913.48"/>
+</g>
+<!-- e_12_center&#45;&gt;akg_c -->
+<g id="edge68" class="edge">
+<title>e_12_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M989.55,-831.58C997.52,-855.22 1040.89,-983.8 1060.08,-1040.69"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1056.85,-1042.08 1063.36,-1050.43 1063.48,-1039.84 1056.85,-1042.08"/>
+</g>
+<!-- e_12_center&#45;&gt;pi_c -->
+<g id="edge70" class="edge">
+<title>e_12_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M984.71,-831.33C967.21,-848.62 889.67,-925.18 852.17,-962.21"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="849.47,-959.95 844.82,-969.47 854.39,-964.93 849.47,-959.95"/>
+</g>
+<!-- e_12_center&#45;&gt;nadp_c -->
+<g id="edge72" class="edge">
+<title>e_12_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M992.2,-828.94C999.61,-831.07 1016.15,-835.93 1029.89,-840.59 1054.51,-848.93 1082.23,-859.33 1102.01,-866.92"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1100.98,-870.28 1111.57,-870.61 1103.5,-863.75 1100.98,-870.28"/>
+</g>
+<!-- co2_e -->
+<g id="node50" class="node">
+<title>co2_e</title>
+<ellipse fill="none" stroke="black" cx="1628.62" cy="-713.55" rx="18" ry="18"/>
+<text text-anchor="middle" x="1628.62" y="-709.85" font-family="Times,serif" font-size="14.00">co2_e</text>
+</g>
+<!-- co2_e&#45;&gt;co2_c -->
+<g id="edge74" class="edge">
+<title>co2_e&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1611.7,-720.42C1552.75,-744.38 1356.06,-824.29 1284.06,-853.55"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1282.32,-850.48 1274.37,-857.48 1284.96,-856.96 1282.32,-850.48"/>
+</g>
+<!-- e_22_target -->
+<g id="node66" class="node">
+<title>e_22_target</title>
+<ellipse fill="black" stroke="black" cx="1877.52" cy="-612.17" rx="1.8" ry="1.8"/>
+</g>
+<!-- co2_e&#45;&gt;e_22_target -->
+<g id="edge101" class="edge">
+<title>co2_e&#45;&gt;e_22_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1645.34,-706.74C1692.55,-687.51 1826.04,-633.14 1866.05,-616.84"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1867.59,-620 1875.53,-612.98 1864.95,-613.52 1867.59,-620"/>
+</g>
+<!-- e_14_center&#45;&gt;coa_c -->
+<g id="edge79" class="edge">
+<title>e_14_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M810.11,-1078.96C830.91,-1081.76 936.09,-1095.91 987.13,-1102.77"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="986.77,-1106.25 997.15,-1104.12 987.71,-1099.31 986.77,-1106.25"/>
+</g>
+<!-- e_14_center&#45;&gt;h_c -->
+<g id="edge80" class="edge">
+<title>e_14_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M810.06,-1080.6C818.15,-1085.43 838.49,-1097.58 855.41,-1107.91 890.92,-1129.59 931.84,-1155.02 957.08,-1170.76"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="955.3,-1173.78 965.63,-1176.1 959,-1167.84 955.3,-1173.78"/>
+</g>
+<!-- e_14_center&#45;&gt;cit_c -->
+<g id="edge78" class="edge">
+<title>e_14_center&#45;&gt;cit_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M802.61,-1077.85C774.19,-1073.27 597.53,-1044.8 527.68,-1033.54"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="527.85,-1030.03 517.42,-1031.89 526.74,-1036.94 527.85,-1030.03"/>
+</g>
+<!-- q8h2_c -->
+<g id="node52" class="node">
+<title>q8h2_c</title>
+<ellipse fill="none" stroke="black" cx="812.2" cy="-1566.75" rx="18" ry="18"/>
+<text text-anchor="middle" x="812.2" y="-1563.05" font-family="Times,serif" font-size="14.00">q8h2_c</text>
+</g>
+<!-- q8h2_c&#45;&gt;e_15_center -->
+<g id="edge81" class="edge">
+<title>q8h2_c&#45;&gt;e_15_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M805.59,-1549.74C789.95,-1509.46 751.37,-1410.13 743.41,-1389.63"/>
+</g>
+<!-- e_43_center -->
+<g id="node104" class="node">
+<title>e_43_center</title>
+<polygon fill="none" stroke="black" points="707.93,-1708.25 700.93,-1708.25 700.93,-1701.25 707.93,-1701.25 707.93,-1708.25"/>
+</g>
+<!-- q8h2_c&#45;&gt;e_43_center -->
+<g id="edge130" class="edge">
+<title>q8h2_c&#45;&gt;e_43_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M796.86,-1576.17C787.24,-1582.58 775.01,-1591.69 766.01,-1601.73 735.42,-1635.87 711.93,-1687.41 705.93,-1701.23"/>
+</g>
+<!-- o2_c -->
+<g id="node53" class="node">
+<title>o2_c</title>
+<ellipse fill="none" stroke="black" cx="496.9" cy="-1726.81" rx="18" ry="18"/>
+<text text-anchor="middle" x="496.9" y="-1723.11" font-family="Times,serif" font-size="14.00">o2_c</text>
+</g>
+<!-- o2_c&#45;&gt;e_15_center -->
+<g id="edge83" class="edge">
+<title>o2_c&#45;&gt;e_15_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M507.43,-1712.16C551.04,-1651.49 716.27,-1421.63 739.29,-1389.6"/>
+</g>
+<!-- q8_c -->
+<g id="node54" class="node">
+<title>q8_c</title>
+<ellipse fill="none" stroke="black" cx="763.56" cy="-1560.62" rx="18" ry="18"/>
+<text text-anchor="middle" x="763.56" y="-1556.92" font-family="Times,serif" font-size="14.00">q8_c</text>
+</g>
+<!-- q8_c&#45;&gt;e_66_center -->
+<g id="edge239" class="edge">
+<title>q8_c&#45;&gt;e_66_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M776.05,-1547.62C817.15,-1504.84 946.85,-1369.83 969.82,-1345.92"/>
+</g>
+<!-- e_88_center -->
+<g id="node150" class="node">
+<title>e_88_center</title>
+<polygon fill="none" stroke="black" points="668.49,-1684.22 661.49,-1684.22 661.49,-1677.22 668.49,-1677.22 668.49,-1684.22"/>
+</g>
+<!-- q8_c&#45;&gt;e_88_center -->
+<g id="edge321" class="edge">
+<title>q8_c&#45;&gt;e_88_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M751.86,-1574.87C729.22,-1602.46 680.52,-1661.8 667.98,-1677.08"/>
+</g>
+<!-- e_15_center&#45;&gt;h2o_c -->
+<g id="edge84" class="edge">
+<title>e_15_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M742.13,-1382.16C742.61,-1371.82 743.93,-1341.92 744.37,-1317.05 744.47,-1311.09 744.41,-1309.6 744.37,-1303.65 743.51,-1184.68 741.02,-1042.88 739.91,-983.61"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="743.4,-983.46 739.72,-973.53 736.41,-983.59 743.4,-983.46"/>
+</g>
+<!-- e_15_center&#45;&gt;h_e -->
+<g id="edge86" class="edge">
+<title>e_15_center&#45;&gt;h_e</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M745.48,-1385.93C768.96,-1386.21 903.51,-1387.83 963.11,-1388.54"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="963.28,-1392.05 973.32,-1388.67 963.36,-1385.05 963.28,-1392.05"/>
+</g>
+<!-- e_15_center&#45;&gt;q8_c -->
+<g id="edge85" class="edge">
+<title>e_15_center&#45;&gt;q8_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M742.41,-1389.54C744.65,-1407.69 754.72,-1489.14 760.11,-1532.79"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="756.65,-1533.26 761.35,-1542.76 763.59,-1532.4 756.65,-1533.26"/>
+</g>
+<!-- lac__D_e -->
+<g id="node56" class="node">
+<title>lac__D_e</title>
+<ellipse fill="none" stroke="black" cx="1432.18" cy="-1785.04" rx="18" ry="18"/>
+<text text-anchor="middle" x="1432.18" y="-1781.34" font-family="Times,serif" font-size="14.00">lac__D_e</text>
+</g>
+<!-- lac__D_e&#45;&gt;e_16_center -->
+<g id="edge88" class="edge">
+<title>lac__D_e&#45;&gt;e_16_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M1421.43,-1770.34C1381.79,-1716.15 1245.06,-1529.21 1223.94,-1500.34"/>
+</g>
+<!-- e_32_target -->
+<g id="node83" class="node">
+<title>e_32_target</title>
+<ellipse fill="black" stroke="black" cx="1591.94" cy="-2000.26" rx="1.8" ry="1.8"/>
+</g>
+<!-- lac__D_e&#45;&gt;e_32_target -->
+<g id="edge111" class="edge">
+<title>lac__D_e&#45;&gt;e_32_target</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1442.91,-1799.5C1473.21,-1840.32 1558.9,-1955.75 1584.58,-1990.34"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="1581.19,-1993.12 1590.66,-1998.54 1588.21,-1987.9 1581.19,-1993.12"/>
+</g>
+<!-- lac__D_c -->
+<g id="node57" class="node">
+<title>lac__D_c</title>
+<ellipse fill="none" stroke="black" cx="1392.51" cy="-1386.26" rx="18" ry="18"/>
+<text text-anchor="middle" x="1392.51" y="-1382.56" font-family="Times,serif" font-size="14.00">lac__D_c</text>
+</g>
+<!-- lac__D_c&#45;&gt;e_60_center -->
+<g id="edge209" class="edge">
+<title>lac__D_c&#45;&gt;e_60_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M1382.32,-1370.76C1362.29,-1340.12 1316.64,-1269.44 1281.18,-1208.27 1271.49,-1191.56 1260.9,-1171.03 1256.74,-1162.85"/>
+</g>
+<!-- e_16_center&#45;&gt;h_c -->
+<g id="edge90" class="edge">
+<title>e_16_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M1218.76,-1492.92C1203.38,-1469.83 1117.61,-1342.21 1037.66,-1245.97 1026.19,-1232.16 1012.41,-1217.47 1001.32,-1206.05"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.49" points="1003.64,-1203.41 994.14,-1198.72 998.64,-1208.31 1003.64,-1203.41"/>
+</g>
+<!-- e_16_center&#45;&gt;lac__D_c -->
+<g id="edge89" class="edge">
+<title>e_16_center&#45;&gt;lac__D_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M1224.76,-1494.27C1243.07,-1482.48 1327.04,-1428.42 1368.79,-1401.53"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.49" points="1370.75,-1404.43 1377.26,-1396.08 1366.96,-1398.55 1370.75,-1404.43"/>
+</g>
+<!-- 2pg_c -->
+<g id="node59" class="node">
+<title>2pg_c</title>
+<ellipse fill="none" stroke="black" cx="684.29" cy="-395.02" rx="18" ry="18"/>
+<text text-anchor="middle" x="684.29" y="-391.32" font-family="Times,serif" font-size="14.00">2pg_c</text>
+</g>
+<!-- 2pg_c&#45;&gt;3pg_c -->
+<g id="edge275" class="edge">
+<title>2pg_c&#45;&gt;3pg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M695.71,-409.1C718.59,-437.31 770.21,-500.96 797.63,-534.77"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.49" points="795.03,-537.12 804.05,-542.68 800.47,-532.71 795.03,-537.12"/>
+</g>
+<!-- e_17_center -->
+<g id="node60" class="node">
+<title>e_17_center</title>
+<polygon fill="none" stroke="black" points="791.89,-629.89 784.89,-629.89 784.89,-622.89 791.89,-622.89 791.89,-629.89"/>
+</g>
+<!-- 2pg_c&#45;&gt;e_17_center -->
+<g id="edge91" class="edge">
+<title>2pg_c&#45;&gt;e_17_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M691.78,-411.66C713.5,-459.94 775.72,-598.21 786.72,-622.67"/>
+</g>
+<!-- e_17_center&#45;&gt;h2o_c -->
+<g id="edge92" class="edge">
+<title>e_17_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M788.43,-630.03C788.57,-650.15 788.21,-749.64 768.44,-827.52 761.87,-853.4 751.13,-856.83 744.87,-882.78 741.41,-897.14 739.96,-913.51 739.41,-927.07"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="735.03,-927.13 739.13,-937.25 743.78,-927.37 735.03,-927.13"/>
+</g>
+<!-- e_17_center&#45;&gt;pep_c -->
+<g id="edge93" class="edge">
+<title>e_17_center&#45;&gt;pep_c</title>
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+<!-- etoh_e&#45;&gt;e_18_center -->
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+<!-- etoh_e&#45;&gt;e_23_target -->
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+<!-- fru_e&#45;&gt;e_44_center -->
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+<!-- e_26_target -->
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+<!-- glc__D_e&#45;&gt;e_27_target -->
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+<!-- gln__L_e&#45;&gt;e_28_target -->
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+<!-- e_29_target -->
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+<!-- glu__L_e -->
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+<!-- glu__L_e&#45;&gt;e_29_target -->
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+<!-- e_31_target -->
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+<!-- h2o_e -->
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+<!-- h2o_e&#45;&gt;h2o_c -->
+<g id="edge200" class="edge">
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+<!-- mal__L_e -->
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+<!-- mal__L_e&#45;&gt;e_33_target -->
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+<!-- nh4_e -->
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+<!-- nh4_e&#45;&gt;e_34_target -->
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+<!-- nh4_e&#45;&gt;nh4_c -->
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+<!-- o2_e -->
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+<!-- o2_e&#45;&gt;o2_c -->
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+<!-- pi_e&#45;&gt;e_36_target -->
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+<title>fdp_c</title>
+<ellipse fill="none" stroke="black" cx="840.62" cy="-486.8" rx="18" ry="18"/>
+<text text-anchor="middle" x="840.62" y="-483.1" font-family="Times,serif" font-size="14.00">fdp_c</text>
+</g>
+<!-- e_39_center -->
+<g id="node98" class="node">
+<title>e_39_center</title>
+<polygon fill="none" stroke="black" points="885.53,-271.53 878.53,-271.53 878.53,-264.53 885.53,-264.53 885.53,-271.53"/>
+</g>
+<!-- fdp_c&#45;&gt;e_39_center -->
+<g id="edge118" class="edge">
+<title>fdp_c&#45;&gt;e_39_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M844.01,-468.9C852.97,-421.55 876.91,-295.05 881.32,-271.75"/>
+</g>
+<!-- fdp_c&#45;&gt;e_40_center -->
+<g id="edge122" class="edge">
+<title>fdp_c&#45;&gt;e_40_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M839.94,-505.13C838.17,-552.92 833.5,-679.23 832.64,-702.49"/>
+</g>
+<!-- dhap_c -->
+<g id="node97" class="node">
+<title>dhap_c</title>
+<ellipse fill="none" stroke="black" cx="939.41" cy="-160.01" rx="18" ry="18"/>
+<text text-anchor="middle" x="939.41" y="-156.31" font-family="Times,serif" font-size="14.00">dhap_c</text>
+</g>
+<!-- dhap_c&#45;&gt;g3p_c -->
+<g id="edge349" class="edge">
+<title>dhap_c&#45;&gt;g3p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M943.33,-177.86C954.38,-228.14 985.83,-371.25 999.17,-431.95"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.4" points="995.46,-433.01 1001.37,-441.95 1002.98,-431.36 995.46,-433.01"/>
+</g>
+<!-- e_39_center&#45;&gt;g3p_c -->
+<g id="edge120" class="edge">
+<title>e_39_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M884.38,-271.69C897.32,-291.83 960.4,-389.93 989.94,-435.88"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.4" points="986.74,-438 995.38,-444.33 993.21,-433.84 986.74,-438"/>
+</g>
+<!-- e_39_center&#45;&gt;dhap_c -->
+<g id="edge119" class="edge">
+<title>e_39_center&#45;&gt;dhap_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M883.94,-264.44C890.41,-252.25 911.9,-211.8 926.15,-184.96"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.4" points="929.56,-186.74 930.86,-176.11 922.77,-183.13 929.56,-186.74"/>
+</g>
+<!-- e_40_center&#45;&gt;pi_c -->
+<g id="edge123" class="edge">
+<title>e_40_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M832.49,-710.11C832.42,-736.51 831.99,-889.82 831.81,-954.07"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="828.31,-954.28 831.79,-964.29 835.31,-954.3 828.31,-954.28"/>
+</g>
+<!-- e_40_center&#45;&gt;f6p_c -->
+<g id="edge124" class="edge">
+<title>e_40_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M836.07,-703.43C857.31,-686.91 967.68,-601.02 1015.74,-563.63"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1017.94,-566.34 1023.69,-557.44 1013.65,-560.82 1017.94,-566.34"/>
+</g>
+<!-- for_c -->
+<g id="node100" class="node">
+<title>for_c</title>
+<ellipse fill="none" stroke="black" cx="1470.76" cy="-1343.74" rx="18" ry="18"/>
+<text text-anchor="middle" x="1470.76" y="-1340.04" font-family="Times,serif" font-size="14.00">for_c</text>
+</g>
+<!-- for_c&#45;&gt;for_e -->
+<g id="edge129" class="edge">
+<title>for_c&#45;&gt;for_e</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1480.02,-1359.6C1499.76,-1393.39 1546.07,-1472.71 1569.63,-1513.04"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1566.63,-1514.85 1574.7,-1521.72 1572.67,-1511.32 1566.63,-1514.85"/>
+</g>
+<!-- e_41_center&#45;&gt;h_c -->
+<g id="edge128" class="edge">
+<title>e_41_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1270.54,-1401.6C1242.81,-1380.93 1067.16,-1249.94 1003.81,-1202.71"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1005.75,-1199.79 995.64,-1196.62 1001.57,-1205.4 1005.75,-1199.79"/>
+</g>
+<!-- e_41_center&#45;&gt;for_c -->
+<g id="edge127" class="edge">
+<title>e_41_center&#45;&gt;for_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1277.92,-1403.16C1292.44,-1398.41 1347.27,-1380.54 1392.67,-1366.66 1409.57,-1361.49 1428.61,-1355.9 1443.65,-1351.53"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1444.72,-1354.86 1453.36,-1348.72 1442.78,-1348.14 1444.72,-1354.86"/>
+</g>
+<!-- fum_c -->
+<g id="node102" class="node">
+<title>fum_c</title>
+<ellipse fill="none" stroke="black" cx="779.73" cy="-1615.73" rx="18" ry="18"/>
+<text text-anchor="middle" x="779.73" y="-1612.03" font-family="Times,serif" font-size="14.00">fum_c</text>
+</g>
+<!-- fum_c&#45;&gt;e_43_center -->
+<g id="edge131" class="edge">
+<title>fum_c&#45;&gt;e_43_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M767.97,-1629.64C750.26,-1650.57 717.76,-1688.99 707.57,-1701.04"/>
+</g>
+<!-- fum_c&#45;&gt;e_45_center -->
+<g id="edge139" class="edge">
+<title>fum_c&#45;&gt;e_45_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M782.81,-1597.81C793.3,-1536.88 827.2,-1339.81 832.18,-1310.89"/>
+</g>
+<!-- succ_c -->
+<g id="node103" class="node">
+<title>succ_c</title>
+<ellipse fill="none" stroke="black" cx="706.39" cy="-1491.69" rx="18" ry="18"/>
+<text text-anchor="middle" x="706.39" y="-1487.99" font-family="Times,serif" font-size="14.00">succ_c</text>
+</g>
+<!-- succ_c&#45;&gt;e_87_center -->
+<g id="edge318" class="edge">
+<title>succ_c&#45;&gt;e_87_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M724.36,-1493.42C763.45,-1497.2 854.24,-1505.99 873.63,-1507.86"/>
+</g>
+<!-- succ_c&#45;&gt;e_88_center -->
+<g id="edge322" class="edge">
+<title>succ_c&#45;&gt;e_88_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M702.5,-1509.47C693.24,-1551.75 670.34,-1656.29 665.78,-1677.09"/>
+</g>
+<!-- succ_c&#45;&gt;e_89_center -->
+<g id="edge327" class="edge">
+<title>succ_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M710.46,-1474.03C715.7,-1451.77 725.31,-1412.41 735.25,-1379.19 760.95,-1293.36 799.23,-1190.53 807.02,-1169.79"/>
+</g>
+<!-- e_43_center&#45;&gt;q8_c -->
+<g id="edge132" class="edge">
+<title>e_43_center&#45;&gt;q8_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M705.89,-1701.19C712.27,-1685.65 737.96,-1623.02 752.81,-1586.82"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="756.13,-1587.95 756.69,-1577.37 749.65,-1585.29 756.13,-1587.95"/>
+</g>
+<!-- e_43_center&#45;&gt;succ_c -->
+<g id="edge133" class="edge">
+<title>e_43_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M704.47,-1701.05C704.66,-1679.8 705.65,-1572.31 706.13,-1520.16"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="709.63,-1519.95 706.23,-1509.92 702.63,-1519.89 709.63,-1519.95"/>
+</g>
+<!-- e_44_center&#45;&gt;f6p_c -->
+<g id="edge137" class="edge">
+<title>e_44_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1267.62,-522.09C1244.87,-524.48 1122.02,-537.38 1066.01,-543.27"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1065.63,-539.79 1056.05,-544.31 1066.36,-546.75 1065.63,-539.79"/>
+</g>
+<!-- e_44_center&#45;&gt;pyr_c -->
+<g id="edge136" class="edge">
+<title>e_44_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1270.65,-525.24C1265.27,-555.55 1226.75,-772.43 1212.84,-850.77"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1209.35,-850.42 1211.04,-860.87 1216.24,-851.64 1209.35,-850.42"/>
+</g>
+<!-- mal__L_c -->
+<g id="node106" class="node">
+<title>mal__L_c</title>
+<ellipse fill="none" stroke="black" cx="1099.9" cy="-1247.54" rx="18" ry="18"/>
+<text text-anchor="middle" x="1099.9" y="-1243.84" font-family="Times,serif" font-size="14.00">mal__L_c</text>
+</g>
+<!-- mal__L_c&#45;&gt;e_63_center -->
+<g id="edge225" class="edge">
+<title>mal__L_c&#45;&gt;e_63_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1094.2,-1230.31C1088.25,-1212.28 1079.32,-1185.24 1076.06,-1175.37"/>
+</g>
+<!-- mal__L_c&#45;&gt;e_64_center -->
+<g id="edge230" class="edge">
+<title>mal__L_c&#45;&gt;e_64_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1112.62,-1234.51C1150.95,-1195.26 1264.01,-1079.51 1285.73,-1057.27"/>
+</g>
+<!-- mal__L_c&#45;&gt;e_65_center -->
+<g id="edge235" class="edge">
+<title>mal__L_c&#45;&gt;e_65_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1108.7,-1231.55C1124.77,-1202.72 1160.38,-1140.39 1194.83,-1090.68 1216.01,-1060.11 1245.01,-1025.77 1254.36,-1014.87"/>
+</g>
+<!-- e_45_center&#45;&gt;mal__L_c -->
+<g id="edge140" class="edge">
+<title>e_45_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M836.5,-1307.13C856.16,-1305.98 950.06,-1299.6 1023.72,-1279.4 1030.15,-1277.63 1031.44,-1276.25 1037.59,-1273.69 1049.57,-1268.71 1062.83,-1263.16 1074.03,-1258.45"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1075.39,-1261.67 1083.25,-1254.57 1072.67,-1255.22 1075.39,-1261.67"/>
+</g>
+<!-- e_46_center&#45;&gt;h_c -->
+<g id="edge143" class="edge">
+<title>e_46_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M954.99,-1589.53C955.61,-1566.56 959.27,-1439.18 966.62,-1335.58 969.63,-1293.09 974.67,-1243.98 977.93,-1213.89"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="981.43,-1214.04 979.04,-1203.72 974.47,-1213.28 981.43,-1214.04"/>
+</g>
+<!-- e_46_center&#45;&gt;fum_c -->
+<g id="edge144" class="edge">
+<title>e_46_center&#45;&gt;fum_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M951.24,-1593.64C933.04,-1595.98 851.39,-1606.5 807.64,-1612.13"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="807.11,-1608.67 797.64,-1613.42 808.01,-1615.61 807.11,-1608.67"/>
+</g>
+<!-- 6pgl_c -->
+<g id="node109" class="node">
+<title>6pgl_c</title>
+<ellipse fill="none" stroke="black" cx="1349.81" cy="-807.12" rx="18" ry="18"/>
+<text text-anchor="middle" x="1349.81" y="-803.42" font-family="Times,serif" font-size="14.00">6pgl_c</text>
+</g>
+<!-- 6pgl_c&#45;&gt;e_75_center -->
+<g id="edge272" class="edge">
+<title>6pgl_c&#45;&gt;e_75_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1332.2,-812.74C1302.98,-822.26 1242.89,-842.71 1194.07,-864.96 1170.64,-875.65 1165.81,-880.45 1142.39,-891.18 1136.33,-893.96 1135.07,-895.66 1128.52,-896.88 1115.81,-899.24 1100.36,-897.57 1093.43,-896.59"/>
+</g>
+<!-- e_47_center&#45;&gt;h_c -->
+<g id="edge148" class="edge">
+<title>e_47_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1202.24,-921.18C1190.06,-939.4 1135.06,-1020.72 1082.98,-1081.74 1056.64,-1112.6 1023.27,-1145.65 1002.04,-1166.01"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="999.36,-1163.73 994.54,-1173.16 1004.19,-1168.8 999.36,-1163.73"/>
+</g>
+<!-- e_47_center&#45;&gt;nadph_c -->
+<g id="edge149" class="edge">
+<title>e_47_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1201.11,-917.64C1193.41,-918.04 1174.74,-919 1158.46,-919.83"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1158.05,-916.35 1148.24,-920.36 1158.41,-923.34 1158.05,-916.35"/>
+</g>
+<!-- e_47_center&#45;&gt;6pgl_c -->
+<g id="edge147" class="edge">
+<title>e_47_center&#45;&gt;6pgl_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1208.48,-915.58C1218.88,-910.35 1248.7,-894.83 1271.13,-878.34 1292.37,-862.73 1314.44,-842.32 1329.78,-827.36"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1332.5,-829.6 1337.15,-820.08 1327.58,-824.62 1332.5,-829.6"/>
+</g>
+<!-- 13dpg_c -->
+<g id="node111" class="node">
+<title>13dpg_c</title>
+<ellipse fill="none" stroke="black" cx="904.29" cy="-601.16" rx="18" ry="18"/>
+<text text-anchor="middle" x="904.29" y="-597.46" font-family="Times,serif" font-size="14.00">13dpg_c</text>
+</g>
+<!-- e_48_center&#45;&gt;h_c -->
+<g id="edge154" class="edge">
+<title>e_48_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1022.72,-851.09C1018.97,-881.2 993.98,-1082 984.61,-1157.3"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="980.24,-1157 983.34,-1167.46 988.92,-1158.08 980.24,-1157"/>
+</g>
+<!-- e_48_center&#45;&gt;nadh_c -->
+<g id="edge153" class="edge">
+<title>e_48_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1025.66,-851.09C1040.34,-873.75 1116.66,-991.52 1149.89,-1042.8"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="1146.27,-1045.27 1155.38,-1051.29 1153.62,-1040.51 1146.27,-1045.27"/>
+</g>
+<!-- e_48_center&#45;&gt;13dpg_c -->
+<g id="edge155" class="edge">
+<title>e_48_center&#45;&gt;13dpg_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1021.32,-843.42C1009.45,-818.85 944.15,-683.67 916.58,-626.6"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="920.48,-624.62 912.19,-617.52 912.6,-628.43 920.48,-624.62"/>
+</g>
+<!-- e_49_center&#45;&gt;pyr_c -->
+<g id="edge158" class="edge">
+<title>e_49_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M1354.16,-592.55C1340.36,-619.56 1254.08,-788.41 1220.86,-853.43"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.4" points="1217.3,-851.94 1216.18,-862.59 1224.16,-855.44 1217.3,-851.94"/>
+</g>
+<!-- e_49_center&#45;&gt;g6p_c -->
+<g id="edge159" class="edge">
+<title>e_49_center&#45;&gt;g6p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M1352.39,-590.75C1335.12,-599.56 1260.82,-637.5 1221.06,-657.8"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.4" points="1219.13,-654.46 1211.98,-662.44 1222.63,-661.32 1219.13,-654.46"/>
+</g>
+<!-- nh4_c&#45;&gt;e_50_center -->
+<g id="edge161" class="edge">
+<title>nh4_c&#45;&gt;e_50_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M565.3,-737.47C596.38,-782.49 688.59,-916.04 704.9,-939.67"/>
+</g>
+<!-- e_50_center&#45;&gt;h_c -->
+<g id="edge165" class="edge">
+<title>e_50_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M709.18,-947.11C711.95,-952.66 717.74,-962.93 725.38,-969.14 743.8,-984.1 755.85,-974 775.68,-987.03 854.84,-1039.06 930.16,-1124.01 963.34,-1163.84"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="960.71,-1166.14 969.77,-1171.63 966.11,-1161.69 960.71,-1166.14"/>
+</g>
+<!-- e_50_center&#45;&gt;adp_c -->
+<g id="edge164" class="edge">
+<title>e_50_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M711.11,-942.23C717.07,-940.62 729.13,-937.51 739.54,-935.81 750.82,-933.96 763.34,-932.61 774.22,-931.65"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="774.76,-935.12 784.44,-930.83 774.19,-928.14 774.76,-935.12"/>
+</g>
+<!-- e_50_center&#45;&gt;pi_c -->
+<g id="edge163" class="edge">
+<title>e_50_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M711.09,-941.61C717.02,-939.15 729.03,-934.89 739.54,-935.81 765.25,-938.04 791.19,-952.49 808.98,-964.7"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="807.32,-967.83 817.49,-970.81 811.41,-962.14 807.32,-967.83"/>
+</g>
+<!-- e_50_center&#45;&gt;gln__L_c -->
+<g id="edge166" class="edge">
+<title>e_50_center&#45;&gt;gln__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M708.67,-939.67C713.24,-926.89 728.99,-882.89 739.36,-853.91"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="742.7,-854.97 742.77,-844.37 736.11,-852.61 742.7,-854.97"/>
+</g>
+<!-- e_51_center&#45;&gt;h_c -->
+<g id="edge172" class="edge">
+<title>e_51_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M644.77,-989.42C663.66,-997.48 748.12,-1034.08 813.19,-1071.78 866.97,-1102.93 926.35,-1145.27 958.07,-1168.59"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="956.14,-1171.51 966.26,-1174.63 960.3,-1165.88 956.14,-1171.51"/>
+</g>
+<!-- e_51_center&#45;&gt;adp_c -->
+<g id="edge171" class="edge">
+<title>e_51_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M644.67,-986.1C655.68,-981.12 688.59,-965.84 714.08,-949.97 719.5,-946.59 720.06,-944.54 725.63,-941.42 731.45,-938.16 733.06,-937.39 739.54,-935.81 750.64,-933.09 763.13,-931.57 774.03,-930.73"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="774.53,-934.21 784.29,-930.1 774.1,-927.22 774.53,-934.21"/>
+</g>
+<!-- e_51_center&#45;&gt;pi_c -->
+<g id="edge170" class="edge">
+<title>e_51_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M644.66,-987.48C659.52,-986.33 715.58,-982.15 761.83,-981.27 775.58,-981.01 790.85,-981.2 803.6,-981.49"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="803.54,-984.99 813.63,-981.75 803.72,-977.99 803.54,-984.99"/>
+</g>
+<!-- e_51_center&#45;&gt;gln__L_c -->
+<g id="edge173" class="edge">
+<title>e_51_center&#45;&gt;gln__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M643.36,-984.13C655.15,-966.61 706.48,-890.35 732.93,-851.04"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="736.1,-852.6 738.78,-842.35 730.3,-848.69 736.1,-852.6"/>
+</g>
+<!-- e_52_center&#45;&gt;h_c -->
+<g id="edge179" class="edge">
+<title>e_52_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M881.56,-923.1C891.25,-948.69 947.74,-1097.77 971.03,-1159.25"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="967.78,-1160.56 974.6,-1168.67 974.33,-1158.08 967.78,-1160.56"/>
+</g>
+<!-- e_52_center&#45;&gt;akg_c -->
+<g id="edge177" class="edge">
+<title>e_52_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M883.71,-920.67C894.13,-924.6 925.31,-936.78 949.34,-950.48 968.86,-961.61 973.91,-964.63 990.68,-979.58 1013.63,-1000.06 1036.66,-1026.83 1051.78,-1045.48"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1049.17,-1047.81 1058.15,-1053.43 1054.63,-1043.44 1049.17,-1047.81"/>
+</g>
+<!-- e_52_center&#45;&gt;nadph_c -->
+<g id="edge180" class="edge">
+<title>e_52_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M883.78,-919.64C898.21,-920.8 952.64,-925.03 997.54,-926.37 1033.53,-927.45 1075.01,-925.32 1101.82,-923.49"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1102.3,-926.97 1112.02,-922.76 1101.8,-919.98 1102.3,-926.97"/>
+</g>
+<!-- e_52_center&#45;&gt;nh4_c -->
+<g id="edge178" class="edge">
+<title>e_52_center&#45;&gt;nh4_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M876.48,-917.52C859.86,-909.24 789.97,-874.07 734.9,-841.2 677.43,-806.88 612.4,-762.6 578.49,-739.06"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="580.38,-736.11 570.17,-733.27 576.38,-741.86 580.38,-736.11"/>
+</g>
+<!-- e_53_center&#45;&gt;glu__L_c -->
+<g id="edge184" class="edge">
+<title>e_53_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M590.84,-849.76C605.19,-863.28 656.76,-911.65 700.68,-949.97 713.41,-961.07 727.93,-973.18 739.62,-982.81"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="737.62,-985.69 747.57,-989.33 742.06,-980.28 737.62,-985.69"/>
+</g>
+<!-- e_53_center&#45;&gt;nh4_c -->
+<g id="edge183" class="edge">
+<title>e_53_center&#45;&gt;nh4_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M586.05,-842.55C582.6,-829.19 570.22,-781.27 562.19,-750.2"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="565.54,-749.2 559.65,-740.39 558.77,-750.95 565.54,-749.2"/>
+</g>
+<!-- e_54_center&#45;&gt;glu__L_c -->
+<g id="edge190" class="edge">
+<title>e_54_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M938.98,-959.3C925.37,-967.04 876.23,-993.7 831.71,-1001.99 818.1,-1004.52 802.74,-1004.57 789.89,-1003.86"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="790.01,-1000.36 779.78,-1003.11 789.5,-1007.34 790.01,-1000.36"/>
+</g>
+<!-- e_54_center&#45;&gt;nadp_c -->
+<g id="edge189" class="edge">
+<title>e_54_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M946.38,-955.58C956.71,-951.12 986.57,-938.12 1010.94,-926.37 1043.4,-910.72 1049.41,-902.23 1083.05,-889.31 1088.58,-887.19 1094.63,-885.3 1100.46,-883.69"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1101.75,-886.97 1110.56,-881.09 1100.01,-880.19 1101.75,-886.97"/>
+</g>
+<!-- e_55_center&#45;&gt;h_c -->
+<g id="edge193" class="edge">
+<title>e_55_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M701.17,-1287.78C727.33,-1278.25 889.66,-1219.07 954.43,-1195.46"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="955.75,-1198.71 963.95,-1191.99 953.36,-1192.13 955.75,-1198.71"/>
+</g>
+<!-- e_55_center&#45;&gt;glu__L_c -->
+<g id="edge194" class="edge">
+<title>e_55_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M698.39,-1285.46C703.25,-1263.58 729.18,-1146.88 750.43,-1051.68 752.09,-1044.25 753.89,-1036.2 755.56,-1028.75"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="759.03,-1029.27 757.8,-1018.74 752.2,-1027.74 759.03,-1029.27"/>
+</g>
+<!-- 6pgc_c -->
+<g id="node121" class="node">
+<title>6pgc_c</title>
+<ellipse fill="none" stroke="black" cx="1336.79" cy="-724.73" rx="18" ry="18"/>
+<text text-anchor="middle" x="1336.79" y="-721.03" font-family="Times,serif" font-size="14.00">6pgc_c</text>
+</g>
+<!-- 6pgc_c&#45;&gt;e_56_center -->
+<g id="edge195" class="edge">
+<title>6pgc_c&#45;&gt;e_56_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1322.36,-713.53C1305.94,-700.8 1280.18,-680.82 1270.75,-673.5"/>
+</g>
+<!-- xu5p__D_c -->
+<g id="node147" class="node">
+<title>xu5p__D_c</title>
+<ellipse fill="none" stroke="black" cx="1246.76" cy="-144.93" rx="18" ry="18"/>
+<text text-anchor="middle" x="1246.76" y="-141.23" font-family="Times,serif" font-size="14.00">xu5p__D_c</text>
+</g>
+<!-- ru5p__D_c&#45;&gt;xu5p__D_c -->
+<g id="edge311" class="edge">
+<title>ru5p__D_c&#45;&gt;xu5p__D_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1299.59,-359.42C1289.64,-319.03 1265.35,-220.39 1253.49,-172.25"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1256.89,-171.39 1251.1,-162.52 1250.09,-173.06 1256.89,-171.39"/>
+</g>
+<!-- e_56_center&#45;&gt;co2_c -->
+<g id="edge198" class="edge">
+<title>e_56_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1266.95,-674.39C1265.95,-694.18 1261.19,-788.49 1258.77,-836.37"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1255.27,-836.22 1258.27,-846.39 1262.27,-836.58 1255.27,-836.22"/>
+</g>
+<!-- e_56_center&#45;&gt;nadph_c -->
+<g id="edge199" class="edge">
+<title>e_56_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1265.19,-674.24C1252.03,-698.3 1175.3,-838.53 1143.65,-896.37"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1140.54,-894.78 1138.81,-905.23 1146.68,-898.14 1140.54,-894.78"/>
+</g>
+<!-- e_56_center&#45;&gt;ru5p__D_c -->
+<g id="edge197" class="edge">
+<title>e_56_center&#45;&gt;ru5p__D_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1267.6,-666.98C1270.98,-640.02 1291.92,-473.35 1300.41,-405.72"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1303.93,-405.75 1301.7,-395.39 1296.99,-404.88 1303.93,-405.75"/>
+</g>
+<!-- e_58_center&#45;&gt;akg_c -->
+<g id="edge204" class="edge">
+<title>e_58_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M987.64,-989.78C997.98,-999.67 1027.99,-1028.36 1048.58,-1048.05"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1046.3,-1050.71 1055.95,-1055.1 1051.14,-1045.66 1046.3,-1050.71"/>
+</g>
+<!-- e_58_center&#45;&gt;co2_c -->
+<g id="edge203" class="edge">
+<title>e_58_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M987.59,-985.5C1005.28,-981.61 1084.24,-963.38 1143.74,-935.29 1179.38,-918.46 1188.77,-914.65 1221.61,-892.86 1226.2,-889.82 1230.93,-886.33 1235.39,-882.86"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1237.91,-885.33 1243.52,-876.34 1233.53,-879.87 1237.91,-885.33"/>
+</g>
+<!-- e_58_center&#45;&gt;nadph_c -->
+<g id="edge205" class="edge">
+<title>e_58_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M987.59,-984.67C1003.4,-977.64 1067.44,-949.14 1104.03,-932.86"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1105.85,-935.88 1113.57,-928.62 1103.01,-929.48 1105.85,-935.88"/>
+</g>
+<!-- glx_c -->
+<g id="node125" class="node">
+<title>glx_c</title>
+<ellipse fill="none" stroke="black" cx="605.92" cy="-1324.92" rx="18" ry="18"/>
+<text text-anchor="middle" x="605.92" y="-1321.22" font-family="Times,serif" font-size="14.00">glx_c</text>
+</g>
+<!-- glx_c&#45;&gt;e_61_center -->
+<g id="edge215" class="edge">
+<title>glx_c&#45;&gt;e_61_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M622.26,-1316.43C673.92,-1289.56 831.84,-1207.43 857.4,-1194.13"/>
+</g>
+<!-- e_59_center&#45;&gt;succ_c -->
+<g id="edge208" class="edge">
+<title>e_59_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M521.04,-1367.22C540.9,-1380.55 637.6,-1445.49 682.9,-1475.91"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="680.98,-1478.84 691.24,-1481.51 684.89,-1473.03 680.98,-1478.84"/>
+</g>
+<!-- e_59_center&#45;&gt;glx_c -->
+<g id="edge207" class="edge">
+<title>e_59_center&#45;&gt;glx_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M521.24,-1363.08C531.23,-1358.58 558.92,-1346.1 579.94,-1336.63"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="581.65,-1339.7 589.33,-1332.4 578.77,-1333.32 581.65,-1339.7"/>
+</g>
+<!-- e_60_center&#45;&gt;h_c -->
+<g id="edge213" class="edge">
+<title>e_60_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M1251.13,-1159.7C1232.62,-1161.97 1149.67,-1172.02 1081.51,-1178.29 1057.16,-1180.53 1029.43,-1182.55 1009.29,-1183.92"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.49" points="1008.97,-1180.44 999.23,-1184.6 1009.44,-1187.42 1008.97,-1180.44"/>
+</g>
+<!-- e_60_center&#45;&gt;nadh_c -->
+<g id="edge212" class="edge">
+<title>e_60_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M1251.2,-1156.19C1241.48,-1148.15 1214.67,-1125.46 1194.83,-1104.08 1190.59,-1099.5 1186.28,-1094.36 1182.32,-1089.4"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.49" points="1184.95,-1087.09 1176.05,-1081.34 1179.43,-1091.39 1184.95,-1087.09"/>
+</g>
+<!-- e_60_center&#45;&gt;pyr_c -->
+<g id="edge211" class="edge">
+<title>e_60_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M1254.31,-1155.69C1250.01,-1130.06 1223.5,-972.18 1212.56,-907.01"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.49" points="1215.99,-906.31 1210.88,-897.03 1209.09,-907.47 1215.99,-906.31"/>
+</g>
+<!-- e_61_center&#45;&gt;coa_c -->
+<g id="edge217" class="edge">
+<title>e_61_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M864.42,-1190.35C880.94,-1181.16 951.77,-1141.72 990.11,-1120.37"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="992.07,-1123.29 999.1,-1115.36 988.67,-1117.17 992.07,-1123.29"/>
+</g>
+<!-- e_61_center&#45;&gt;h_c -->
+<g id="edge219" class="edge">
+<title>e_61_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M864.64,-1192.1C877.77,-1191.39 922.66,-1188.94 952.71,-1187.3"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="953.23,-1190.78 963.02,-1186.74 952.84,-1183.79 953.23,-1190.78"/>
+</g>
+<!-- e_61_center&#45;&gt;mal__L_c -->
+<g id="edge218" class="edge">
+<title>e_61_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M864.67,-1193.17C888.15,-1198.6 1015.64,-1228.07 1072.5,-1241.21"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1071.72,-1244.62 1082.26,-1243.46 1073.3,-1237.8 1071.72,-1244.62"/>
+</g>
+<!-- e_62_center&#45;&gt;h_c -->
+<g id="edge223" class="edge">
+<title>e_62_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1091.91,-1513.72C1083.72,-1490.85 1038.46,-1364.03 1004.17,-1259.75 999.11,-1244.36 993.7,-1227.09 989.39,-1213.11"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="992.61,-1211.68 986.34,-1203.14 985.92,-1213.73 992.61,-1211.68"/>
+</g>
+<!-- e_62_center&#45;&gt;mal__L_c -->
+<g id="edge222" class="edge">
+<title>e_62_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1093.3,-1513.52C1093.94,-1487.79 1097.64,-1338.67 1099.2,-1275.65"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1102.7,-1275.7 1099.45,-1265.61 1095.7,-1275.52 1102.7,-1275.7"/>
+</g>
+<!-- e_63_center&#45;&gt;h_c -->
+<g id="edge227" class="edge">
+<title>e_63_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1071.25,-1172.13C1061.14,-1173.66 1031.56,-1178.12 1009.01,-1181.53"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1008.29,-1178.1 998.93,-1183.05 1009.34,-1185.02 1008.29,-1178.1"/>
+</g>
+<!-- e_63_center&#45;&gt;nadh_c -->
+<g id="edge226" class="edge">
+<title>e_63_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1078.37,-1167.82C1090.49,-1154.99 1129.7,-1113.41 1135.01,-1107.07 1139.63,-1101.57 1144.4,-1095.45 1148.76,-1089.67"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1151.63,-1091.68 1154.78,-1081.57 1146.01,-1087.51 1151.63,-1091.68"/>
+</g>
+<!-- e_63_center&#45;&gt;oaa_c -->
+<g id="edge228" class="edge">
+<title>e_63_center&#45;&gt;oaa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1073.28,-1168.01C1068.19,-1156.33 1050.87,-1118.63 1028.98,-1092.78 1021.52,-1083.98 1016.61,-1084.88 1008.99,-1076.22 991.57,-1056.42 975.9,-1030.69 965.5,-1011.94"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="968.54,-1010.21 960.7,-1003.09 962.39,-1013.55 968.54,-1010.21"/>
+</g>
+<!-- e_64_center&#45;&gt;nadh_c -->
+<g id="edge233" class="edge">
+<title>e_64_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1285.78,-1053.93C1272.5,-1055.34 1225.17,-1060.36 1193.95,-1063.67"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1193.24,-1060.23 1183.67,-1064.76 1193.98,-1067.19 1193.24,-1060.23"/>
+</g>
+<!-- e_64_center&#45;&gt;co2_c -->
+<g id="edge231" class="edge">
+<title>e_64_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1288.75,-1049.94C1285.49,-1030.71 1270.04,-939.35 1262.09,-892.4"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1265.5,-891.57 1260.38,-882.3 1258.6,-892.74 1265.5,-891.57"/>
+</g>
+<!-- e_64_center&#45;&gt;pyr_c -->
+<g id="edge232" class="edge">
+<title>e_64_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1287.66,-1049.91C1279.04,-1031.46 1239.91,-947.61 1219.82,-904.57"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1222.9,-902.89 1215.49,-895.31 1216.55,-905.85 1222.9,-902.89"/>
+</g>
+<!-- e_65_center&#45;&gt;co2_c -->
+<g id="edge236" class="edge">
+<title>e_65_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1257.39,-1007.72C1257.39,-992.11 1257.37,-929.85 1257.36,-892.72"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1260.86,-892.53 1257.36,-882.53 1253.86,-892.53 1260.86,-892.53"/>
+</g>
+<!-- e_65_center&#45;&gt;pyr_c -->
+<g id="edge237" class="edge">
+<title>e_65_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1256.06,-1007.81C1250.71,-993.49 1230.36,-939.09 1217.87,-905.71"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1221.05,-904.23 1214.27,-896.09 1214.49,-906.68 1221.05,-904.23"/>
+</g>
+<!-- e_65_center&#45;&gt;nadph_c -->
+<g id="edge238" class="edge">
+<title>e_65_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1253.71,-1008.75C1239.17,-998.47 1184.92,-960.11 1153.3,-937.76"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1155.22,-934.83 1145.03,-931.91 1151.17,-940.54 1155.22,-934.83"/>
+</g>
+<!-- e_66_center&#45;&gt;nad_c -->
+<g id="edge242" class="edge">
+<title>e_66_center&#45;&gt;nad_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M974.68,-1338.48C978.91,-1326.71 992.25,-1289.91 1004.17,-1259.75 1006.62,-1253.55 1006.7,-1251.73 1009.94,-1245.9 1031.54,-1207.2 1042,-1200.71 1068.11,-1164.89 1080.14,-1148.4 1093.85,-1129.88 1104.33,-1115.79"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1107.23,-1117.76 1110.4,-1107.64 1101.62,-1113.57 1107.23,-1117.76"/>
+</g>
+<!-- e_66_center&#45;&gt;h_e -->
+<g id="edge243" class="edge">
+<title>e_66_center&#45;&gt;h_e</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M974.75,-1345.94C976.21,-1349.69 978.63,-1355.88 981.17,-1362.41"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="978.01,-1363.93 984.91,-1371.97 984.53,-1361.38 978.01,-1363.93"/>
+</g>
+<!-- e_66_center&#45;&gt;q8h2_c -->
+<g id="edge244" class="edge">
+<title>e_66_center&#45;&gt;q8h2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M970.79,-1345.81C954.7,-1368.21 866.22,-1491.5 828.86,-1543.55"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="825.9,-1541.67 822.91,-1551.83 831.58,-1545.75 825.9,-1541.67"/>
+</g>
+<!-- e_67_center&#45;&gt;nadh_c -->
+<g id="edge248" class="edge">
+<title>e_67_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1294.41,-957.97C1279.3,-970.71 1219.58,-1021.03 1186.95,-1048.52"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1184.67,-1045.87 1179.28,-1054.99 1189.18,-1051.22 1184.67,-1045.87"/>
+</g>
+<!-- e_67_center&#45;&gt;nadp_c -->
+<g id="edge247" class="edge">
+<title>e_67_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1294.39,-953.02C1282.67,-946.58 1244.26,-925.75 1211.41,-910.76 1192.83,-902.27 1171.45,-893.66 1155.07,-887.3"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1156.17,-883.97 1145.58,-883.65 1153.65,-890.5 1156.17,-883.97"/>
+</g>
+<!-- e_70_center&#45;&gt;nadh_c -->
+<g id="edge255" class="edge">
+<title>e_70_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1196.1,-1000.29C1192.6,-1007.86 1184.45,-1025.46 1177.43,-1040.65"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1174.06,-1039.6 1173.03,-1050.15 1180.41,-1042.54 1174.06,-1039.6"/>
+</g>
+<!-- e_70_center&#45;&gt;accoa_c -->
+<g id="edge256" class="edge">
+<title>e_70_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1194.19,-997.89C1175.83,-1004.8 1092.88,-1036.03 1049.5,-1052.36"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1048.01,-1049.18 1039.88,-1055.98 1050.47,-1055.74 1048.01,-1049.18"/>
+</g>
+<!-- e_70_center&#45;&gt;co2_c -->
+<g id="edge254" class="edge">
+<title>e_70_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1199.43,-992.98C1205.93,-978.56 1230.78,-923.39 1245.74,-890.18"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1248.94,-891.6 1249.86,-881.05 1242.56,-888.73 1248.94,-891.6"/>
+</g>
+<!-- e_71_center&#45;&gt;h_c -->
+<g id="edge261" class="edge">
+<title>e_71_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M900.54,-788.34C901.27,-799.95 903.79,-836.25 908.27,-866.04 924.77,-975.78 958.35,-1103.77 973.44,-1158.59"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.4" points="969.73,-1159.64 976.11,-1168.25 977.15,-1157.59 969.73,-1159.64"/>
+</g>
+<!-- e_71_center&#45;&gt;adp_c -->
+<g id="edge260" class="edge">
+<title>e_71_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M897.89,-788.18C887.09,-804.19 842.73,-869.94 818.46,-905.92"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.4" points="815.16,-903.93 812.76,-914.37 821.54,-908.24 815.16,-903.93"/>
+</g>
+<!-- e_71_center&#45;&gt;fdp_c -->
+<g id="edge259" class="edge">
+<title>e_71_center&#45;&gt;fdp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M899.55,-780.83C894.05,-753.35 859.86,-582.82 846.23,-514.78"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.4" points="849.96,-513.83 844.22,-504.78 842.41,-515.34 849.96,-513.83"/>
+</g>
+<!-- e_72_center&#45;&gt;accoa_c -->
+<g id="edge265" class="edge">
+<title>e_72_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1277.86,-1120.69C1260.44,-1121.98 1182.52,-1126.69 1121.11,-1112.72 1114.61,-1111.24 1113.36,-1109.64 1107.29,-1106.88 1083.88,-1096.25 1077.91,-1093.74 1055.26,-1081.55 1052.53,-1080.08 1049.7,-1078.5 1046.9,-1076.89"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1048.61,-1073.84 1038.21,-1071.81 1045.08,-1079.88 1048.61,-1073.84"/>
+</g>
+<!-- e_72_center&#45;&gt;for_c -->
+<g id="edge264" class="edge">
+<title>e_72_center&#45;&gt;for_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1284.4,-1123.91C1303.47,-1146.41 1409.19,-1271.12 1452.38,-1322.06"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1449.85,-1324.48 1458.98,-1329.85 1455.19,-1319.96 1449.85,-1324.48"/>
+</g>
+<!-- e_74_center&#45;&gt;adp_c -->
+<g id="edge269" class="edge">
+<title>e_74_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M742.29,-694.8C748.29,-718.25 780.88,-845.58 795.41,-902.36"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.49" points="792.03,-903.28 797.9,-912.1 798.81,-901.54 792.03,-903.28"/>
+</g>
+<!-- e_74_center&#45;&gt;13dpg_c -->
+<g id="edge270" class="edge">
+<title>e_74_center&#45;&gt;13dpg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M745.04,-689.01C762.71,-679.26 839.19,-637.07 879.39,-614.9"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.49" points="881.24,-617.87 888.3,-609.98 877.86,-611.74 881.24,-617.87"/>
+</g>
+<!-- e_75_center&#45;&gt;h_c -->
+<g id="edge274" class="edge">
+<title>e_75_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1087,-899.88C1074.63,-917.51 1023.86,-992.41 1003.27,-1062.35 993.86,-1094.33 987.77,-1132.2 984.39,-1157.48"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="980.9,-1157.12 983.1,-1167.48 987.85,-1158.01 980.9,-1157.12"/>
+</g>
+<!-- e_75_center&#45;&gt;6pgc_c -->
+<g id="edge273" class="edge">
+<title>e_75_center&#45;&gt;6pgc_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1092,-892.24C1095.99,-885.77 1104.82,-872.41 1114.75,-863.38 1177.92,-805.99 1267.9,-758.18 1311.36,-736.79"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1312.93,-739.91 1320.39,-732.39 1309.86,-733.62 1312.93,-739.91"/>
+</g>
+<!-- e_77_center&#45;&gt;h_c -->
+<g id="edge279" class="edge">
+<title>e_77_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M741.49,-1308.39C765.79,-1295.95 899.47,-1227.52 955.91,-1198.63"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="957.59,-1201.7 964.89,-1194.03 954.4,-1195.47 957.59,-1201.7"/>
+</g>
+<!-- e_77_center&#45;&gt;pi_c -->
+<g id="edge278" class="edge">
+<title>e_77_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M738.49,-1306.67C743.52,-1284.48 770.67,-1166.26 799.79,-1071.78 806.37,-1050.45 814.92,-1026.67 821.53,-1009"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="824.9,-1009.96 825.16,-999.37 818.35,-1007.49 824.9,-1009.96"/>
+</g>
+<!-- e_78_center&#45;&gt;h_c -->
+<g id="edge284" class="edge">
+<title>e_78_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1003.91,-923.44C1001.71,-948.7 989.01,-1094.58 983.56,-1157.21"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="980.04,-1157.28 982.66,-1167.54 987.01,-1157.88 980.04,-1157.28"/>
+</g>
+<!-- e_78_center&#45;&gt;pi_c -->
+<g id="edge283" class="edge">
+<title>e_78_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1000.64,-920.98C982.59,-927.55 901.16,-957.15 858.3,-972.73"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="856.99,-969.48 848.79,-976.19 859.38,-976.06 856.99,-969.48"/>
+</g>
+<!-- e_78_center&#45;&gt;oaa_c -->
+<g id="edge285" class="edge">
+<title>e_78_center&#45;&gt;oaa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1001.46,-923.29C995.54,-930.97 981.3,-949.46 969.68,-964.54"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="966.9,-962.41 963.57,-972.47 972.45,-966.68 966.9,-962.41"/>
+</g>
+<!-- e_79_center&#45;&gt;adp_c -->
+<g id="edge289" class="edge">
+<title>e_79_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M976.66,-796.4C957.33,-811.2 867.53,-879.9 824.94,-912.48"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="822.66,-909.82 816.85,-918.67 826.92,-915.37 822.66,-909.82"/>
+</g>
+<!-- e_79_center&#45;&gt;co2_c -->
+<g id="edge288" class="edge">
+<title>e_79_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M983.88,-794.46C1009.27,-800.95 1165.93,-841.01 1230.04,-857.41"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1229.3,-860.83 1239.85,-859.92 1231.03,-854.05 1229.3,-860.83"/>
+</g>
+<!-- e_79_center&#45;&gt;pep_c -->
+<g id="edge290" class="edge">
+<title>e_79_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M983.4,-789.88C994.12,-776.83 1030.85,-732.12 1053.28,-704.81"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1056.09,-706.9 1059.74,-696.95 1050.69,-702.45 1056.09,-706.9"/>
+</g>
+<!-- e_80_center&#45;&gt;h_c -->
+<g id="edge297" class="edge">
+<title>e_80_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M915.34,-862.91C916.94,-878 923.58,-938.03 932.87,-986.74 944.69,-1048.66 963.26,-1120.29 973.56,-1158.46"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="970.24,-1159.57 976.23,-1168.31 976.99,-1157.74 970.24,-1159.57"/>
+</g>
+<!-- e_80_center&#45;&gt;amp_c -->
+<g id="edge295" class="edge">
+<title>e_80_center&#45;&gt;amp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M911.4,-855.45C893.92,-836.4 815.37,-751.21 748.03,-684.35 738.78,-675.18 728.31,-665.26 719.37,-656.93"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="721.68,-654.3 711.97,-650.07 716.93,-659.44 721.68,-654.3"/>
+</g>
+<!-- e_80_center&#45;&gt;pi_c -->
+<g id="edge294" class="edge">
+<title>e_80_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M911.78,-863.1C904.58,-871.64 886.69,-893.28 873.44,-912.64 863.46,-927.2 853.28,-944.19 845.47,-957.76"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="842.38,-956.11 840.47,-966.53 848.46,-959.57 842.38,-956.11"/>
+</g>
+<!-- e_80_center&#45;&gt;pep_c -->
+<g id="edge296" class="edge">
+<title>e_80_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M917.81,-855.64C926.14,-844.84 951.32,-812.49 973.68,-786.86 999.79,-756.93 1031.51,-723.68 1051.54,-703.04"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1054.14,-705.38 1058.61,-695.78 1049.13,-700.5 1054.14,-705.38"/>
+</g>
+<!-- e_81_center&#45;&gt;coa_c -->
+<g id="edge300" class="edge">
+<title>e_81_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M763.52,-1125.01C776.22,-1124.74 819.64,-1123.68 855.41,-1121.31 901.36,-1118.28 954.59,-1112.98 986.49,-1109.62"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="987.26,-1113.06 996.83,-1108.52 986.52,-1106.09 987.26,-1113.06"/>
+</g>
+<!-- e_81_center&#45;&gt;actp_c -->
+<g id="edge301" class="edge">
+<title>e_81_center&#45;&gt;actp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M755.98,-1125.54C740.59,-1127.34 682.5,-1134.03 634.59,-1138.62 589.35,-1142.95 536.74,-1147.17 505.19,-1149.62"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="504.66,-1146.15 494.96,-1150.41 505.2,-1153.13 504.66,-1146.15"/>
+</g>
+<!-- e_82_center&#45;&gt;atp_c -->
+<g id="edge306" class="edge">
+<title>e_82_center&#45;&gt;atp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M974.79,-893.69C953.39,-892.59 844.94,-887.02 792.69,-884.33"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.4" points="792.63,-880.47 782.45,-883.8 792.24,-888.16 792.63,-880.47"/>
+</g>
+<!-- e_82_center&#45;&gt;pyr_c -->
+<g id="edge305" class="edge">
+<title>e_82_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M982.18,-894.6C996.69,-897.33 1051.46,-906.77 1096.45,-902.71 1110.88,-901.41 1114.32,-899.78 1128.52,-896.88 1145.83,-893.35 1165.17,-888.98 1180.42,-885.43"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.4" points="1181.39,-889.16 1190.24,-883.13 1179.63,-881.66 1181.39,-889.16"/>
+</g>
+<!-- e_83_center&#45;&gt;h_c -->
+<g id="edge310" class="edge">
+<title>e_83_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1284,-1201.37C1255.62,-1199.91 1079.18,-1190.81 1009.41,-1187.21"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1009.34,-1183.71 999.17,-1186.69 1008.98,-1190.7 1009.34,-1183.71"/>
+</g>
+<!-- e_83_center&#45;&gt;pyr_c -->
+<g id="edge309" class="edge">
+<title>e_83_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1286.98,-1197.95C1279.88,-1169.31 1232.59,-978.7 1214.69,-906.53"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1218.08,-905.64 1212.27,-896.78 1211.28,-907.33 1218.08,-905.64"/>
+</g>
+<!-- xu5p__D_c&#45;&gt;e_92_center -->
+<g id="edge341" class="edge">
+<title>xu5p__D_c&#45;&gt;e_92_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1231.35,-154.43C1201.24,-173 1136.16,-213.12 1120.36,-222.86"/>
+</g>
+<!-- xu5p__D_c&#45;&gt;e_93_center -->
+<g id="edge346" class="edge">
+<title>xu5p__D_c&#45;&gt;e_93_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1235.6,-159.34C1207.29,-195.92 1133.82,-290.82 1118.64,-310.43"/>
+</g>
+<!-- e_86_center&#45;&gt;h_c -->
+<g id="edge315" class="edge">
+<title>e_86_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M905.7,-1516.98C912.5,-1487.11 957.91,-1287.52 974.78,-1213.4"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="978.25,-1213.94 977.05,-1203.41 971.42,-1212.38 978.25,-1213.94"/>
+</g>
+<!-- e_86_center&#45;&gt;succ_c -->
+<g id="edge316" class="edge">
+<title>e_86_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M901.06,-1520.18C880.69,-1517.2 783.27,-1502.94 734.44,-1495.79"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="734.92,-1492.32 724.52,-1494.34 733.91,-1499.25 734.92,-1492.32"/>
+</g>
+<!-- e_87_center&#45;&gt;h_c -->
+<g id="edge320" class="edge">
+<title>e_87_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M878.48,-1504.6C887.71,-1475.91 949.27,-1284.6 972.35,-1212.86"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="975.73,-1213.77 975.46,-1203.18 969.07,-1211.62 975.73,-1213.77"/>
+</g>
+<!-- e_87_center&#45;&gt;succ_e -->
+<g id="edge319" class="edge">
+<title>e_87_center&#45;&gt;succ_e</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M876.91,-1511.73C873.97,-1537.04 855.88,-1692.63 848.35,-1757.35"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="844.84,-1757.29 847.16,-1767.63 851.79,-1758.1 844.84,-1757.29"/>
+</g>
+<!-- e_88_center&#45;&gt;q8h2_c -->
+<g id="edge323" class="edge">
+<title>e_88_center&#45;&gt;q8h2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M668.82,-1677.69C682.18,-1667.13 727.9,-1631.06 766.01,-1601.73 773.57,-1595.91 781.87,-1589.6 789.33,-1583.96"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="791.72,-1586.54 797.6,-1577.72 787.51,-1580.95 791.72,-1586.54"/>
+</g>
+<!-- e_88_center&#45;&gt;fum_c -->
+<g id="edge324" class="edge">
+<title>e_88_center&#45;&gt;fum_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M668.55,-1678.71C681.39,-1671.43 726.12,-1646.1 754.78,-1629.86"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="756.83,-1632.72 763.81,-1624.75 753.38,-1626.63 756.83,-1632.72"/>
+</g>
+<!-- e_89_center&#45;&gt;adp_c -->
+<g id="edge329" class="edge">
+<title>e_89_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M807.9,-1162.35C806.27,-1150.91 801.38,-1115.07 799.79,-1085.18 797.43,-1040.81 799.19,-989.23 800.74,-958.05"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="804.24,-958.09 801.28,-947.92 797.25,-957.72 804.24,-958.09"/>
+</g>
+<!-- e_89_center&#45;&gt;succoa_c -->
+<g id="edge330" class="edge">
+<title>e_89_center&#45;&gt;succoa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M811.96,-1167.04C821.21,-1169.7 846.93,-1177.31 867.61,-1185.61 914.87,-1204.56 968.07,-1230.97 998.58,-1246.64"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="997.16,-1249.84 1007.65,-1251.32 1000.37,-1243.62 997.16,-1249.84"/>
+</g>
+<!-- e_89_center&#45;&gt;pi_c -->
+<g id="edge328" class="edge">
+<title>e_89_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M808.88,-1162.54C811.23,-1143.99 822.34,-1056.41 828.16,-1010.55"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="831.67,-1010.74 829.45,-1000.38 824.72,-1009.86 831.67,-1010.74"/>
+</g>
+<!-- s7p_c -->
+<g id="node152" class="node">
+<title>s7p_c</title>
+<ellipse fill="none" stroke="black" cx="1091.98" cy="-39.09" rx="18" ry="18"/>
+<text text-anchor="middle" x="1091.98" y="-35.39" font-family="Times,serif" font-size="14.00">s7p_c</text>
+</g>
+<!-- s7p_c&#45;&gt;e_90_center -->
+<g id="edge331" class="edge">
+<title>s7p_c&#45;&gt;e_90_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1088.56,-57.16C1078.9,-108.28 1051.78,-251.76 1047.19,-276.04"/>
+</g>
+<!-- e_90_center&#45;&gt;f6p_c -->
+<g id="edge334" class="edge">
+<title>e_90_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1046.11,-283.2C1043.92,-302.56 1033.87,-395.18 1033.61,-471.22 1033.55,-486.7 1034.52,-503.95 1035.58,-518"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1032.1,-518.35 1036.39,-528.03 1039.07,-517.79 1032.1,-518.35"/>
+</g>
+<!-- e_90_center&#45;&gt;e4p_c -->
+<g id="edge333" class="edge">
+<title>e_90_center&#45;&gt;e4p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1046.66,-283.22C1047.34,-302.72 1050.56,-395.32 1052.22,-442.92"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1048.73,-443.29 1052.57,-453.16 1055.72,-443.05 1048.73,-443.29"/>
+</g>
+<!-- e_91_center&#45;&gt;nad_c -->
+<g id="edge338" class="edge">
+<title>e_91_center&#45;&gt;nad_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1116.48,-1137.76C1116.88,-1134.01 1117.53,-1127.92 1118.22,-1121.42"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1121.74,-1121.47 1119.32,-1111.16 1114.78,-1120.73 1121.74,-1121.47"/>
+</g>
+<!-- e_91_center&#45;&gt;h_c -->
+<g id="edge339" class="edge">
+<title>e_91_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1112.46,-1142.74C1097.87,-1147.52 1042.41,-1165.67 1008.38,-1176.81"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1006.99,-1173.58 998.58,-1180.02 1009.17,-1180.23 1006.99,-1173.58"/>
+</g>
+<!-- e_91_center&#45;&gt;nadph_c -->
+<g id="edge340" class="edge">
+<title>e_91_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1114.24,-1137.64C1110.61,-1129.52 1102.72,-1110.19 1101.65,-1092.99 1098.43,-1041.56 1112.09,-982.46 1121.57,-948.73"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1125.05,-949.29 1124.47,-938.71 1118.33,-947.34 1125.05,-949.29"/>
+</g>
+<!-- e_92_center&#45;&gt;g3p_c -->
+<g id="edge344" class="edge">
+<title>e_92_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1115.1,-228.71C1104.04,-251.98 1043.5,-379.3 1017.33,-434.34"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1014.14,-432.9 1013.01,-443.43 1020.46,-435.91 1014.14,-432.9"/>
+</g>
+<!-- e_92_center&#45;&gt;s7p_c -->
+<g id="edge343" class="edge">
+<title>e_92_center&#45;&gt;s7p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1116.38,-221.48C1113.85,-202.61 1101.89,-113.21 1095.71,-66.96"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1099.17,-66.44 1094.37,-56.99 1092.23,-67.37 1099.17,-66.44"/>
+</g>
+<!-- e_93_center&#45;&gt;f6p_c -->
+<g id="edge348" class="edge">
+<title>e_93_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1115.19,-317.88C1111.76,-336.83 1095.47,-421.42 1067,-485.23 1061.78,-496.94 1055.74,-509.78 1050.55,-520.65"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1047.24,-519.46 1046.06,-529.99 1053.55,-522.49 1047.24,-519.46"/>
+</g>
+<!-- e_93_center&#45;&gt;g3p_c -->
+<g id="edge347" class="edge">
+<title>e_93_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1113.14,-317.61C1100.81,-333.85 1049.81,-401.03 1022.59,-436.9"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1019.47,-435.21 1016.21,-445.29 1025.05,-439.44 1019.47,-435.21"/>
+</g>
+</g>
+</svg>
\ No newline at end of file
diff --git a/jupyter_execute/dec6276183962256e742330421b2a44e56185827fc963f98fbd9ba25aef73f96.svg b/jupyter_execute/dec6276183962256e742330421b2a44e56185827fc963f98fbd9ba25aef73f96.svg
new file mode 100644
index 00000000..d076da63
--- /dev/null
+++ b/jupyter_execute/dec6276183962256e742330421b2a44e56185827fc963f98fbd9ba25aef73f96.svg
@@ -0,0 +1,137 @@
+<?xml version="1.0" encoding="UTF-8" standalone="no"?>
+<!DOCTYPE svg PUBLIC "-//W3C//DTD SVG 1.1//EN"
+ "http://www.w3.org/Graphics/SVG/1.1/DTD/svg11.dtd">
+<!-- Generated by graphviz version 2.43.0 (0)
+ -->
+<!-- Title: %3 Pages: 1 -->
+<svg width="44pt" height="699pt"
+ viewBox="0.00 0.00 44.00 699.20" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
+<g id="graph0" class="graph" transform="scale(1 1) rotate(0) translate(4 695.2)">
+<title>%3</title>
+<polygon fill="white" stroke="transparent" points="-4,4 -4,-695.2 40,-695.2 40,4 -4,4"/>
+<!-- 3066 -->
+<g id="node1" class="node">
+<title>3066</title>
+<ellipse fill="none" stroke="black" cx="18" cy="-201.6" rx="18" ry="18"/>
+<text text-anchor="middle" x="18" y="-197.9" font-family="Times,serif" font-size="14.00">3066</text>
+</g>
+<!-- 1511 -->
+<g id="node2" class="node">
+<title>1511</title>
+<ellipse fill="none" stroke="black" cx="18" cy="-129.6" rx="18" ry="18"/>
+<text text-anchor="middle" x="18" y="-125.9" font-family="Times,serif" font-size="14.00">1511</text>
+</g>
+<!-- 3066&#45;&gt;1511 -->
+<g id="edge1" class="edge">
+<title>3066&#45;&gt;1511</title>
+<path fill="none" stroke="black" d="M18,-183.3C18,-175.58 18,-166.31 18,-157.71"/>
+<polygon fill="black" stroke="black" points="21.5,-157.7 18,-147.7 14.5,-157.7 21.5,-157.7"/>
+</g>
+<!-- 3629 -->
+<g id="node9" class="node">
+<title>3629</title>
+<ellipse fill="none" stroke="black" cx="18" cy="-57.6" rx="18" ry="18"/>
+<text text-anchor="middle" x="18" y="-53.9" font-family="Times,serif" font-size="14.00">3629</text>
+</g>
+<!-- 1511&#45;&gt;3629 -->
+<g id="edge8" class="edge">
+<title>1511&#45;&gt;3629</title>
+<path fill="none" stroke="black" d="M18,-111.3C18,-103.58 18,-94.31 18,-85.71"/>
+<polygon fill="black" stroke="black" points="21.5,-85.7 18,-75.7 14.5,-85.7 21.5,-85.7"/>
+</g>
+<!-- 32 -->
+<g id="node3" class="node">
+<title>32</title>
+<ellipse fill="none" stroke="black" cx="18" cy="-417.6" rx="18" ry="18"/>
+<text text-anchor="middle" x="18" y="-413.9" font-family="Times,serif" font-size="14.00">32</text>
+</g>
+<!-- 676 -->
+<g id="node4" class="node">
+<title>676</title>
+<ellipse fill="none" stroke="black" cx="18" cy="-345.6" rx="18" ry="18"/>
+<text text-anchor="middle" x="18" y="-341.9" font-family="Times,serif" font-size="14.00">676</text>
+</g>
+<!-- 32&#45;&gt;676 -->
+<g id="edge2" class="edge">
+<title>32&#45;&gt;676</title>
+<path fill="none" stroke="black" d="M18,-399.3C18,-391.58 18,-382.31 18,-373.71"/>
+<polygon fill="black" stroke="black" points="21.5,-373.7 18,-363.7 14.5,-373.7 21.5,-373.7"/>
+</g>
+<!-- 1125 -->
+<g id="node5" class="node">
+<title>1125</title>
+<ellipse fill="none" stroke="black" cx="18" cy="-273.6" rx="18" ry="18"/>
+<text text-anchor="middle" x="18" y="-269.9" font-family="Times,serif" font-size="14.00">1125</text>
+</g>
+<!-- 676&#45;&gt;1125 -->
+<g id="edge3" class="edge">
+<title>676&#45;&gt;1125</title>
+<path fill="none" stroke="black" d="M18,-327.3C18,-319.58 18,-310.31 18,-301.71"/>
+<polygon fill="black" stroke="black" points="21.5,-301.7 18,-291.7 14.5,-301.7 21.5,-301.7"/>
+</g>
+<!-- 1125&#45;&gt;3066 -->
+<g id="edge7" class="edge">
+<title>1125&#45;&gt;3066</title>
+<path fill="none" stroke="black" d="M18,-255.3C18,-247.58 18,-238.31 18,-229.71"/>
+<polygon fill="black" stroke="black" points="21.5,-229.7 18,-219.7 14.5,-229.7 21.5,-229.7"/>
+</g>
+<!-- 3439 -->
+<g id="node6" class="node">
+<title>3439</title>
+<ellipse fill="none" stroke="black" cx="18" cy="-633.6" rx="18" ry="18"/>
+<text text-anchor="middle" x="18" y="-629.9" font-family="Times,serif" font-size="14.00">3439</text>
+</g>
+<!-- 125 -->
+<g id="node7" class="node">
+<title>125</title>
+<ellipse fill="none" stroke="black" cx="18" cy="-561.6" rx="18" ry="18"/>
+<text text-anchor="middle" x="18" y="-557.9" font-family="Times,serif" font-size="14.00">125</text>
+</g>
+<!-- 3439&#45;&gt;125 -->
+<g id="edge4" class="edge">
+<title>3439&#45;&gt;125</title>
+<path fill="none" stroke="black" d="M18,-615.3C18,-607.58 18,-598.31 18,-589.71"/>
+<polygon fill="black" stroke="black" points="21.5,-589.7 18,-579.7 14.5,-589.7 21.5,-589.7"/>
+</g>
+<!-- 38 -->
+<g id="node8" class="node">
+<title>38</title>
+<ellipse fill="none" stroke="black" cx="18" cy="-489.6" rx="18" ry="18"/>
+<text text-anchor="middle" x="18" y="-485.9" font-family="Times,serif" font-size="14.00">38</text>
+</g>
+<!-- 125&#45;&gt;38 -->
+<g id="edge6" class="edge">
+<title>125&#45;&gt;38</title>
+<path fill="none" stroke="black" d="M18,-543.3C18,-535.58 18,-526.31 18,-517.71"/>
+<polygon fill="black" stroke="black" points="21.5,-517.7 18,-507.7 14.5,-517.7 21.5,-517.7"/>
+</g>
+<!-- 38&#45;&gt;32 -->
+<g id="edge5" class="edge">
+<title>38&#45;&gt;32</title>
+<path fill="none" stroke="black" d="M18,-471.3C18,-463.58 18,-454.31 18,-445.71"/>
+<polygon fill="black" stroke="black" points="21.5,-445.7 18,-435.7 14.5,-445.7 21.5,-445.7"/>
+</g>
+<!-- e_9_target -->
+<g id="node11" class="node">
+<title>e_9_target</title>
+<ellipse fill="black" stroke="black" cx="18" cy="-1.8" rx="1.8" ry="1.8"/>
+</g>
+<!-- 3629&#45;&gt;e_9_target -->
+<g id="edge10" class="edge">
+<title>3629&#45;&gt;e_9_target</title>
+<path fill="none" stroke="black" d="M18,-39.58C18,-31.17 18,-21.28 18,-13.87"/>
+<polygon fill="black" stroke="black" points="21.5,-13.73 18,-3.73 14.5,-13.73 21.5,-13.73"/>
+</g>
+<!-- e_8_source -->
+<g id="node10" class="node">
+<title>e_8_source</title>
+<ellipse fill="black" stroke="black" cx="18" cy="-689.4" rx="1.8" ry="1.8"/>
+</g>
+<!-- e_8_source&#45;&gt;3439 -->
+<g id="edge9" class="edge">
+<title>e_8_source&#45;&gt;3439</title>
+<path fill="none" stroke="black" d="M18,-687.47C18,-684.24 18,-673.15 18,-661.95"/>
+<polygon fill="black" stroke="black" points="21.5,-661.86 18,-651.86 14.5,-661.86 21.5,-661.86"/>
+</g>
+</g>
+</svg>
\ No newline at end of file
diff --git a/jupyter_execute/eb3415394c9f08fabfe60fdc383035155cbbd36db6b706e0265150618fe18179.svg b/jupyter_execute/eb3415394c9f08fabfe60fdc383035155cbbd36db6b706e0265150618fe18179.svg
new file mode 100644
index 00000000..84924a89
--- /dev/null
+++ b/jupyter_execute/eb3415394c9f08fabfe60fdc383035155cbbd36db6b706e0265150618fe18179.svg
@@ -0,0 +1,2802 @@
+<?xml version="1.0" encoding="UTF-8" standalone="no"?>
+<!DOCTYPE svg PUBLIC "-//W3C//DTD SVG 1.1//EN"
+ "http://www.w3.org/Graphics/SVG/1.1/DTD/svg11.dtd">
+<!-- Generated by graphviz version 2.43.0 (0)
+ -->
+<!-- Title: %3 Pages: 1 -->
+<svg width="2099pt" height="2511pt"
+ viewBox="0.00 0.00 2099.00 2511.00" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
+<g id="graph0" class="graph" transform="scale(1 1) rotate(0) translate(4 2507)">
+<title>%3</title>
+<polygon fill="white" stroke="transparent" points="-4,4 -4,-2507 2095,-2507 2095,4 -4,4"/>
+<!-- acald_c -->
+<g id="node1" class="node">
+<title>acald_c</title>
+<ellipse fill="none" stroke="black" cx="1463.73" cy="-1375.02" rx="18" ry="18"/>
+<text text-anchor="middle" x="1463.73" y="-1371.32" font-family="Times,serif" font-size="14.00">acald_c</text>
+</g>
+<!-- e_0_center -->
+<g id="node7" class="node">
+<title>e_0_center</title>
+<polygon fill="none" stroke="black" points="1109.89,-1309.27 1102.89,-1309.27 1102.89,-1302.27 1109.89,-1302.27 1109.89,-1309.27"/>
+</g>
+<!-- acald_c&#45;&gt;e_0_center -->
+<g id="edge1" class="edge">
+<title>acald_c&#45;&gt;e_0_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1446.01,-1371.58C1378.97,-1358.59 1143.04,-1312.87 1110.19,-1306.51"/>
+</g>
+<!-- coa_c -->
+<g id="node2" class="node">
+<title>coa_c</title>
+<ellipse fill="none" stroke="black" cx="853.92" cy="-1209.28" rx="18" ry="18"/>
+<text text-anchor="middle" x="853.92" y="-1205.58" font-family="Times,serif" font-size="14.00">coa_c</text>
+</g>
+<!-- coa_c&#45;&gt;e_0_center -->
+<g id="edge2" class="edge">
+<title>coa_c&#45;&gt;e_0_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M870.88,-1216.47C896.39,-1227.22 946.2,-1247.96 989.06,-1264.25 1033.49,-1281.14 1088.21,-1299.66 1102.71,-1304.54"/>
+</g>
+<!-- e_7_center -->
+<g id="node28" class="node">
+<title>e_7_center</title>
+<polygon fill="none" stroke="black" points="1089.98,-1225.34 1082.98,-1225.34 1082.98,-1218.34 1089.98,-1218.34 1089.98,-1225.34"/>
+</g>
+<!-- coa_c&#45;&gt;e_7_center -->
+<g id="edge25" class="edge">
+<title>coa_c&#45;&gt;e_7_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M872.05,-1210.31C892.15,-1211.47 925.53,-1213.42 954.28,-1215.22 995.23,-1217.78 1005.4,-1219.65 1046.4,-1221.28 1059.75,-1221.81 1075.62,-1221.86 1082.72,-1221.85"/>
+</g>
+<!-- e_70_center -->
+<g id="node135" class="node">
+<title>e_70_center</title>
+<polygon fill="none" stroke="black" points="962.56,-1086.92 955.56,-1086.92 955.56,-1079.92 962.56,-1079.92 962.56,-1086.92"/>
+</g>
+<!-- coa_c&#45;&gt;e_70_center -->
+<g id="edge251" class="edge">
+<title>coa_c&#45;&gt;e_70_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.67" d="M865.57,-1195.33C889.31,-1166.91 942.18,-1103.62 955.81,-1087.31"/>
+</g>
+<!-- e_72_center -->
+<g id="node137" class="node">
+<title>e_72_center</title>
+<polygon fill="none" stroke="black" points="618.84,-1227.66 611.84,-1227.66 611.84,-1220.66 618.84,-1220.66 618.84,-1227.66"/>
+</g>
+<!-- coa_c&#45;&gt;e_72_center -->
+<g id="edge262" class="edge">
+<title>coa_c&#45;&gt;e_72_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M835.97,-1211.33C802.79,-1215.02 729.6,-1222.62 667.67,-1225.28 649.33,-1226.07 627.35,-1224.92 618.9,-1224.4"/>
+</g>
+<!-- e_89_center -->
+<g id="node151" class="node">
+<title>e_89_center</title>
+<polygon fill="none" stroke="black" points="747.48,-1303.97 740.48,-1303.97 740.48,-1296.97 747.48,-1296.97 747.48,-1303.97"/>
+</g>
+<!-- coa_c&#45;&gt;e_89_center -->
+<g id="edge326" class="edge">
+<title>coa_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.74" d="M839.99,-1220.82C814.57,-1241.91 761.94,-1285.57 747.64,-1297.44"/>
+</g>
+<!-- nad_c -->
+<g id="node3" class="node">
+<title>nad_c</title>
+<ellipse fill="none" stroke="black" cx="1095.67" cy="-1181.36" rx="18" ry="18"/>
+<text text-anchor="middle" x="1095.67" y="-1177.66" font-family="Times,serif" font-size="14.00">nad_c</text>
+</g>
+<!-- nad_c&#45;&gt;e_0_center -->
+<g id="edge3" class="edge">
+<title>nad_c&#45;&gt;e_0_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1097.23,-1199.45C1099.81,-1229.37 1104.8,-1287.35 1106.08,-1302.22"/>
+</g>
+<!-- nad_c&#45;&gt;e_7_center -->
+<g id="edge26" class="edge">
+<title>nad_c&#45;&gt;e_7_center</title>
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+<!-- e_9_center -->
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+<!-- nad_c&#45;&gt;e_9_center -->
+<g id="edge36" class="edge">
+<title>nad_c&#45;&gt;e_9_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1105.91,-1196.49C1132.36,-1235.59 1201.9,-1338.4 1215.75,-1358.88"/>
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+<!-- e_12_center -->
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+<!-- nad_c&#45;&gt;e_12_center -->
+<g id="edge66" class="edge">
+<title>nad_c&#45;&gt;e_12_center</title>
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+<!-- e_48_center -->
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+<!-- nad_c&#45;&gt;e_48_center -->
+<g id="edge151" class="edge">
+<title>nad_c&#45;&gt;e_48_center</title>
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+<!-- e_60_center -->
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+<!-- nad_c&#45;&gt;e_60_center -->
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+<title>nad_c&#45;&gt;e_60_center</title>
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+<!-- e_63_center -->
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+<!-- nad_c&#45;&gt;e_63_center -->
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+<!-- e_64_center -->
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+<!-- nad_c&#45;&gt;e_64_center -->
+<g id="edge230" class="edge">
+<title>nad_c&#45;&gt;e_64_center</title>
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+<!-- e_67_center -->
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+<!-- nad_c&#45;&gt;e_67_center -->
+<g id="edge246" class="edge">
+<title>nad_c&#45;&gt;e_67_center</title>
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+<!-- nad_c&#45;&gt;e_70_center -->
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+<title>nad_c&#45;&gt;e_70_center</title>
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+<!-- accoa_c -->
+<g id="node4" class="node">
+<title>accoa_c</title>
+<ellipse fill="none" stroke="black" cx="810.37" cy="-1159.91" rx="18" ry="18"/>
+<text text-anchor="middle" x="810.37" y="-1156.21" font-family="Times,serif" font-size="14.00">accoa_c</text>
+</g>
+<!-- accoa_c&#45;&gt;e_12_center -->
+<g id="edge63" class="edge">
+<title>accoa_c&#45;&gt;e_12_center</title>
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+<!-- e_14_center -->
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+<!-- accoa_c&#45;&gt;e_14_center -->
+<g id="edge75" class="edge">
+<title>accoa_c&#45;&gt;e_14_center</title>
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+<!-- e_61_center -->
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+<!-- accoa_c&#45;&gt;e_61_center -->
+<g id="edge214" class="edge">
+<title>accoa_c&#45;&gt;e_61_center</title>
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+<!-- e_81_center -->
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+<!-- accoa_c&#45;&gt;e_81_center -->
+<g id="edge298" class="edge">
+<title>accoa_c&#45;&gt;e_81_center</title>
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+</g>
+<!-- nadh_c -->
+<g id="node5" class="node">
+<title>nadh_c</title>
+<ellipse fill="none" stroke="black" cx="1046.46" cy="-1201.68" rx="18" ry="18"/>
+<text text-anchor="middle" x="1046.46" y="-1197.98" font-family="Times,serif" font-size="14.00">nadh_c</text>
+</g>
+<!-- e_66_center -->
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+<title>e_66_center</title>
+<polygon fill="none" stroke="black" points="969.17,-1479.02 962.17,-1479.02 962.17,-1472.02 969.17,-1472.02 969.17,-1479.02"/>
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+<!-- nadh_c&#45;&gt;e_66_center -->
+<g id="edge240" class="edge">
+<title>nadh_c&#45;&gt;e_66_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1041.28,-1219.22C1024.91,-1274.71 974.88,-1444.3 966.78,-1471.75"/>
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+<!-- e_91_center -->
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+<title>e_91_center</title>
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+<!-- nadh_c&#45;&gt;e_91_center -->
+<g id="edge336" class="edge">
+<title>nadh_c&#45;&gt;e_91_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1059.26,-1214.66C1075.64,-1231.26 1103.04,-1259.03 1112.73,-1268.87"/>
+</g>
+<!-- h_c -->
+<g id="node6" class="node">
+<title>h_c</title>
+<ellipse fill="none" stroke="black" cx="911.41" cy="-1310.11" rx="18" ry="18"/>
+<text text-anchor="middle" x="911.41" y="-1306.41" font-family="Times,serif" font-size="14.00">h_c</text>
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+<!-- e_15_center -->
+<g id="node55" class="node">
+<title>e_15_center</title>
+<polygon fill="none" stroke="black" points="740.69,-1560.2 733.69,-1560.2 733.69,-1553.2 740.69,-1553.2 740.69,-1560.2"/>
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+<!-- h_c&#45;&gt;e_15_center -->
+<g id="edge83" class="edge">
+<title>h_c&#45;&gt;e_15_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M899.89,-1324.51C878.68,-1351.19 832.36,-1410.34 796.42,-1462.44 772.72,-1496.8 746.85,-1540.28 739.34,-1553.03"/>
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+<!-- e_54_center -->
+<g id="node119" class="node">
+<title>e_54_center</title>
+<polygon fill="none" stroke="black" points="1093.53,-1117 1086.53,-1117 1086.53,-1110 1093.53,-1110 1093.53,-1117"/>
+</g>
+<!-- h_c&#45;&gt;e_54_center -->
+<g id="edge185" class="edge">
+<title>h_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M923.69,-1296.6C960.1,-1256.52 1066.24,-1139.68 1086.62,-1117.25"/>
+</g>
+<!-- h_c&#45;&gt;e_66_center -->
+<g id="edge241" class="edge">
+<title>h_c&#45;&gt;e_66_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M913.63,-1328.02C915.97,-1344.85 920.22,-1370.64 926.62,-1392.38 928.5,-1398.77 929.61,-1400.16 932.32,-1406.25 943.63,-1431.61 958.58,-1461.49 963.78,-1471.8"/>
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+<!-- e_82_center -->
+<g id="node145" class="node">
+<title>e_82_center</title>
+<polygon fill="none" stroke="black" points="780.91,-1045.84 773.91,-1045.84 773.91,-1038.84 780.91,-1038.84 780.91,-1045.84"/>
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+<!-- h_c&#45;&gt;e_82_center -->
+<g id="edge303" class="edge">
+<title>h_c&#45;&gt;e_82_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.12" d="M905.12,-1292.95C897.72,-1272.85 884.98,-1238.6 873.52,-1209.37 871.08,-1203.17 870.81,-1201.46 867.85,-1195.49 837.11,-1133.53 790.92,-1062.75 779.86,-1046.02"/>
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+<!-- e_0_center&#45;&gt;accoa_c -->
+<g id="edge4" class="edge">
+<title>e_0_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1102.89,-1303.69C1089.9,-1296.01 1043.15,-1268.84 1002.46,-1250.85 975.85,-1239.08 967.5,-1240.37 940.88,-1228.62 902.9,-1211.87 860.69,-1188.78 834.84,-1174.1"/>
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+<!-- e_0_center&#45;&gt;nadh_c -->
+<g id="edge5" class="edge">
+<title>e_0_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1104.11,-1301.81C1097.06,-1289.58 1075.21,-1251.61 1060.52,-1226.1"/>
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+<!-- e_0_center&#45;&gt;h_c -->
+<g id="edge6" class="edge">
+<title>e_0_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1102.67,-1305.85C1082.74,-1306.29 987.81,-1308.41 939.62,-1309.49"/>
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+<!-- acald_e -->
+<g id="node8" class="node">
+<title>acald_e</title>
+<ellipse fill="none" stroke="black" cx="1845.44" cy="-1428.03" rx="18" ry="18"/>
+<text text-anchor="middle" x="1845.44" y="-1424.33" font-family="Times,serif" font-size="14.00">acald_e</text>
+</g>
+<!-- acald_e&#45;&gt;acald_c -->
+<g id="edge7" class="edge">
+<title>acald_e&#45;&gt;acald_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1827.54,-1425.55C1766.43,-1417.06 1565.72,-1389.18 1491.58,-1378.88"/>
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+<!-- e_20_target -->
+<g id="node64" class="node">
+<title>e_20_target</title>
+<ellipse fill="black" stroke="black" cx="2089.18" cy="-1466.88" rx="1.8" ry="1.8"/>
+</g>
+<!-- acald_e&#45;&gt;e_20_target -->
+<g id="edge99" class="edge">
+<title>acald_e&#45;&gt;e_20_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1863.36,-1430.89C1910.67,-1438.43 2037.97,-1458.72 2077.38,-1465"/>
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+<!-- atp_c -->
+<g id="node9" class="node">
+<title>atp_c</title>
+<ellipse fill="none" stroke="black" cx="722.32" cy="-1049.99" rx="18" ry="18"/>
+<text text-anchor="middle" x="722.32" y="-1046.29" font-family="Times,serif" font-size="14.00">atp_c</text>
+</g>
+<!-- e_2_center -->
+<g id="node13" class="node">
+<title>e_2_center</title>
+<polygon fill="none" stroke="black" points="489.88,-1132.95 482.88,-1132.95 482.88,-1125.95 489.88,-1125.95 489.88,-1132.95"/>
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+<!-- atp_c&#45;&gt;e_2_center -->
+<g id="edge8" class="edge">
+<title>atp_c&#45;&gt;e_2_center</title>
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+</g>
+<!-- e_6_center -->
+<g id="node24" class="node">
+<title>e_6_center</title>
+<polygon fill="none" stroke="black" points="528.76,-914.56 521.76,-914.56 521.76,-907.56 528.76,-907.56 528.76,-914.56"/>
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+<!-- atp_c&#45;&gt;e_6_center -->
+<g id="edge22" class="edge">
+<title>atp_c&#45;&gt;e_6_center</title>
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+<!-- e_10_center -->
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+<title>e_10_center</title>
+<polygon fill="none" stroke="black" points="711.89,-1184.23 704.89,-1184.23 704.89,-1177.23 711.89,-1177.23 711.89,-1184.23"/>
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+<!-- atp_c&#45;&gt;e_10_center -->
+<g id="edge40" class="edge">
+<title>atp_c&#45;&gt;e_10_center</title>
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+<!-- atp_c&#45;&gt;e_12_center -->
+<g id="edge62" class="edge">
+<title>atp_c&#45;&gt;e_12_center</title>
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+<!-- e_50_center -->
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+<!-- atp_c&#45;&gt;e_50_center -->
+<g id="edge160" class="edge">
+<title>atp_c&#45;&gt;e_50_center</title>
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+<!-- e_51_center -->
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+<!-- atp_c&#45;&gt;e_51_center -->
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+<title>atp_c&#45;&gt;e_51_center</title>
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+<!-- e_71_center -->
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+<!-- atp_c&#45;&gt;e_71_center -->
+<g id="edge257" class="edge">
+<title>atp_c&#45;&gt;e_71_center</title>
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+<!-- e_74_center -->
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+<!-- atp_c&#45;&gt;e_74_center -->
+<g id="edge268" class="edge">
+<title>atp_c&#45;&gt;e_74_center</title>
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+<!-- e_79_center -->
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+<!-- atp_c&#45;&gt;e_79_center -->
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+<title>atp_c&#45;&gt;e_79_center</title>
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+<!-- e_80_center -->
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+<!-- atp_c&#45;&gt;e_80_center -->
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+<title>atp_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M705.91,-1042.29C692.82,-1036.16 675.51,-1028.04 668.11,-1024.57"/>
+</g>
+<!-- atp_c&#45;&gt;e_89_center -->
+<g id="edge325" class="edge">
+<title>atp_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.74" d="M728.97,-1066.98C735,-1083.39 743.41,-1109.08 746.57,-1132.24 755.5,-1197.65 746.65,-1278.68 744.45,-1296.77"/>
+</g>
+<!-- ac_c -->
+<g id="node10" class="node">
+<title>ac_c</title>
+<ellipse fill="none" stroke="black" cx="421.51" cy="-1397.64" rx="18" ry="18"/>
+<text text-anchor="middle" x="421.51" y="-1393.94" font-family="Times,serif" font-size="14.00">ac_c</text>
+</g>
+<!-- ac_c&#45;&gt;e_2_center -->
+<g id="edge9" class="edge">
+<title>ac_c&#45;&gt;e_2_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M425.77,-1380.05C439.02,-1325.27 479.02,-1159.89 485.49,-1133.12"/>
+</g>
+<!-- actp_c -->
+<g id="node11" class="node">
+<title>actp_c</title>
+<ellipse fill="none" stroke="black" cx="325.97" cy="-1083.54" rx="18" ry="18"/>
+<text text-anchor="middle" x="325.97" y="-1079.84" font-family="Times,serif" font-size="14.00">actp_c</text>
+</g>
+<!-- adp_c -->
+<g id="node12" class="node">
+<title>adp_c</title>
+<ellipse fill="none" stroke="black" cx="717.1" cy="-1005.95" rx="18" ry="18"/>
+<text text-anchor="middle" x="717.1" y="-1002.25" font-family="Times,serif" font-size="14.00">adp_c</text>
+</g>
+<!-- e_11_center -->
+<g id="node35" class="node">
+<title>e_11_center</title>
+<polygon fill="none" stroke="black" points="786.66,-1247.53 779.66,-1247.53 779.66,-1240.53 786.66,-1240.53 786.66,-1247.53"/>
+</g>
+<!-- adp_c&#45;&gt;e_11_center -->
+<g id="edge47" class="edge">
+<title>adp_c&#45;&gt;e_11_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M727.54,-1020.75C732.79,-1029 738.71,-1039.69 741.92,-1050.11 747.83,-1069.36 777.39,-1215.44 782.43,-1240.41"/>
+</g>
+<!-- adp_c&#45;&gt;e_82_center -->
+<g id="edge304" class="edge">
+<title>adp_c&#45;&gt;e_82_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.12" d="M732.63,-1015.32C746.32,-1023.58 765.3,-1035.03 773.44,-1039.95"/>
+</g>
+<!-- e_2_center&#45;&gt;actp_c -->
+<g id="edge10" class="edge">
+<title>e_2_center&#45;&gt;actp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M482.73,-1128.4C465.69,-1123.53 393.2,-1102.78 353.04,-1091.29"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="353.92,-1087.9 343.34,-1088.52 351.99,-1094.63 353.92,-1087.9"/>
+</g>
+<!-- e_2_center&#45;&gt;adp_c -->
+<g id="edge11" class="edge">
+<title>e_2_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M490,-1127.51C512.88,-1115.26 638.04,-1048.27 692.16,-1019.3"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="693.94,-1022.32 701.1,-1014.51 690.63,-1016.15 693.94,-1022.32"/>
+</g>
+<!-- cit_c -->
+<g id="node14" class="node">
+<title>cit_c</title>
+<ellipse fill="none" stroke="black" cx="368.41" cy="-1238.7" rx="18" ry="18"/>
+<text text-anchor="middle" x="368.41" y="-1235" font-family="Times,serif" font-size="14.00">cit_c</text>
+</g>
+<!-- e_3_center -->
+<g id="node17" class="node">
+<title>e_3_center</title>
+<polygon fill="none" stroke="black" points="393.82,-1145.99 386.82,-1145.99 386.82,-1138.99 393.82,-1138.99 393.82,-1145.99"/>
+</g>
+<!-- cit_c&#45;&gt;e_3_center -->
+<g id="edge12" class="edge">
+<title>cit_c&#45;&gt;e_3_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M372.43,-1221.05C377.72,-1197.83 386.67,-1158.53 389.46,-1146.26"/>
+</g>
+<!-- acon_C_c -->
+<g id="node15" class="node">
+<title>acon_C_c</title>
+<ellipse fill="none" stroke="black" cx="208.35" cy="-1202.14" rx="18" ry="18"/>
+<text text-anchor="middle" x="208.35" y="-1198.44" font-family="Times,serif" font-size="14.00">acon_C_c</text>
+</g>
+<!-- e_4_center -->
+<g id="node19" class="node">
+<title>e_4_center</title>
+<polygon fill="none" stroke="black" points="453.87,-1244.9 446.87,-1244.9 446.87,-1237.9 453.87,-1237.9 453.87,-1244.9"/>
+</g>
+<!-- acon_C_c&#45;&gt;e_4_center -->
+<g id="edge15" class="edge">
+<title>acon_C_c&#45;&gt;e_4_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M226.74,-1203.12C256.67,-1204.94 317.69,-1209.54 368.53,-1219.1 399.21,-1224.87 435.2,-1236.38 446.67,-1240.16"/>
+</g>
+<!-- h2o_c -->
+<g id="node16" class="node">
+<title>h2o_c</title>
+<ellipse fill="none" stroke="black" cx="726.97" cy="-1132.23" rx="18" ry="18"/>
+<text text-anchor="middle" x="726.97" y="-1128.53" font-family="Times,serif" font-size="14.00">h2o_c</text>
+</g>
+<!-- h2o_c&#45;&gt;e_4_center -->
+<g id="edge16" class="edge">
+<title>h2o_c&#45;&gt;e_4_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M710.08,-1138.89C654.96,-1160.65 482.19,-1228.84 454.21,-1239.89"/>
+</g>
+<!-- h2o_c&#45;&gt;e_10_center -->
+<g id="edge41" class="edge">
+<title>h2o_c&#45;&gt;e_10_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.51" d="M720.47,-1149.19C716.62,-1159.25 712.07,-1171.14 709.81,-1177.04"/>
+</g>
+<!-- h2o_c&#45;&gt;e_12_center -->
+<g id="edge58" class="edge">
+<title>h2o_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M737.77,-1117.34C744.05,-1109.12 752.35,-1098.95 760.71,-1090.78 828.84,-1024.2 926.52,-959.14 946.36,-946.16"/>
+</g>
+<!-- h2o_c&#45;&gt;e_14_center -->
+<g id="edge76" class="edge">
+<title>h2o_c&#45;&gt;e_14_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M715.78,-1146.87C700.18,-1167.28 672.83,-1203.06 663.89,-1214.76"/>
+</g>
+<!-- e_40_center -->
+<g id="node99" class="node">
+<title>e_40_center</title>
+<polygon fill="none" stroke="black" points="793.71,-837.53 786.71,-837.53 786.71,-830.53 793.71,-830.53 793.71,-837.53"/>
+</g>
+<!-- h2o_c&#45;&gt;e_40_center -->
+<g id="edge121" class="edge">
+<title>h2o_c&#45;&gt;e_40_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M730.74,-1114.46C743.29,-1055.28 783.24,-866.89 789.41,-837.81"/>
+</g>
+<!-- e_45_center -->
+<g id="node107" class="node">
+<title>e_45_center</title>
+<polygon fill="none" stroke="black" points="806.62,-1472.64 799.62,-1472.64 799.62,-1465.64 806.62,-1465.64 806.62,-1472.64"/>
+</g>
+<!-- h2o_c&#45;&gt;e_45_center -->
+<g id="edge138" class="edge">
+<title>h2o_c&#45;&gt;e_45_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M730.96,-1149.86C745.53,-1214.31 795.38,-1434.88 802.32,-1465.58"/>
+</g>
+<!-- h2o_c&#45;&gt;e_51_center -->
+<g id="edge169" class="edge">
+<title>h2o_c&#45;&gt;e_51_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M713.1,-1120.02C689.2,-1098.98 641.48,-1056.98 627.85,-1044.98"/>
+</g>
+<!-- e_52_center -->
+<g id="node117" class="node">
+<title>e_52_center</title>
+<polygon fill="none" stroke="black" points="1058.43,-1101.64 1051.43,-1101.64 1051.43,-1094.64 1058.43,-1094.64 1058.43,-1101.64"/>
+</g>
+<!-- h2o_c&#45;&gt;e_52_center -->
+<g id="edge175" class="edge">
+<title>h2o_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.57" d="M744.78,-1129.34C787.17,-1122.63 897.43,-1106 990.23,-1099.35 1013.54,-1097.68 1041.68,-1097.92 1051.42,-1098.07"/>
+</g>
+<!-- e_53_center -->
+<g id="node118" class="node">
+<title>e_53_center</title>
+<polygon fill="none" stroke="black" points="1025.69,-977.67 1018.69,-977.67 1018.69,-970.67 1025.69,-970.67 1025.69,-977.67"/>
+</g>
+<!-- h2o_c&#45;&gt;e_53_center -->
+<g id="edge181" class="edge">
+<title>h2o_c&#45;&gt;e_53_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M745.25,-1130.14C754.18,-1128.88 765.03,-1126.97 774.53,-1124.26 780.94,-1122.42 782.46,-1121.57 788.39,-1118.53 886.1,-1068.62 996.96,-991.87 1018.47,-976.79"/>
+</g>
+<!-- h2o_c&#45;&gt;e_61_center -->
+<g id="edge215" class="edge">
+<title>h2o_c&#45;&gt;e_61_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M730.42,-1150.06C735.97,-1179.74 746.66,-1241.2 750.68,-1293.77 752.03,-1311.35 751.49,-1332.45 751.19,-1340.84"/>
+</g>
+<!-- e_75_center -->
+<g id="node139" class="node">
+<title>e_75_center</title>
+<polygon fill="none" stroke="black" points="1082.37,-1040.83 1075.37,-1040.83 1075.37,-1033.83 1082.37,-1033.83 1082.37,-1040.83"/>
+</g>
+<!-- h2o_c&#45;&gt;e_75_center -->
+<g id="edge272" class="edge">
+<title>h2o_c&#45;&gt;e_75_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M745.13,-1129.67C754.03,-1128.3 764.89,-1126.43 774.53,-1124.26 838.04,-1109.91 1044.8,-1047.62 1075.14,-1038.45"/>
+</g>
+<!-- e_78_center -->
+<g id="node141" class="node">
+<title>e_78_center</title>
+<polygon fill="none" stroke="black" points="885.39,-1033.68 878.39,-1033.68 878.39,-1026.68 885.39,-1026.68 885.39,-1033.68"/>
+</g>
+<!-- h2o_c&#45;&gt;e_78_center -->
+<g id="edge282" class="edge">
+<title>h2o_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.66" d="M737.73,-1117.3C744,-1109.07 752.31,-1098.91 760.71,-1090.78 782.92,-1069.31 789.23,-1064.03 816.08,-1048.74 837.74,-1036.41 868.15,-1031.82 878.38,-1030.57"/>
+</g>
+<!-- h2o_c&#45;&gt;e_80_center -->
+<g id="edge293" class="edge">
+<title>h2o_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M718.02,-1116.56C703.32,-1090.81 674.85,-1040.99 666.73,-1026.76"/>
+</g>
+<!-- e_3_center&#45;&gt;acon_C_c -->
+<g id="edge13" class="edge">
+<title>e_3_center&#45;&gt;acon_C_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M386.52,-1143.73C367.34,-1150.02 280.36,-1178.53 235.42,-1193.26"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3" points="234.14,-1190 225.73,-1196.44 236.32,-1196.65 234.14,-1190"/>
+</g>
+<!-- e_3_center&#45;&gt;h2o_c -->
+<g id="edge14" class="edge">
+<title>e_3_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M394.02,-1142.39C414.46,-1141.86 515.74,-1139.17 598.5,-1136.59 632.85,-1135.52 672.36,-1134.16 698.4,-1133.24"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3" points="698.81,-1136.73 708.68,-1132.88 698.56,-1129.74 698.81,-1136.73"/>
+</g>
+<!-- icit_c -->
+<g id="node18" class="node">
+<title>icit_c</title>
+<ellipse fill="none" stroke="black" cx="668.2" cy="-1365.43" rx="18" ry="18"/>
+<text text-anchor="middle" x="668.2" y="-1361.73" font-family="Times,serif" font-size="14.00">icit_c</text>
+</g>
+<!-- e_58_center -->
+<g id="node124" class="node">
+<title>e_58_center</title>
+<polygon fill="none" stroke="black" points="1001.97,-1169.74 994.97,-1169.74 994.97,-1162.74 1001.97,-1162.74 1001.97,-1169.74"/>
+</g>
+<!-- icit_c&#45;&gt;e_58_center -->
+<g id="edge202" class="edge">
+<title>icit_c&#45;&gt;e_58_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M683.69,-1356.09C744.39,-1319.48 964.29,-1186.85 994.92,-1168.38"/>
+</g>
+<!-- e_59_center -->
+<g id="node126" class="node">
+<title>e_59_center</title>
+<polygon fill="none" stroke="black" points="543.05,-1617.62 536.05,-1617.62 536.05,-1610.62 543.05,-1610.62 543.05,-1617.62"/>
+</g>
+<!-- icit_c&#45;&gt;e_59_center -->
+<g id="edge206" class="edge">
+<title>icit_c&#45;&gt;e_59_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M659.76,-1381.75C633.6,-1432.32 554.83,-1584.59 541.48,-1610.38"/>
+</g>
+<!-- e_4_center&#45;&gt;icit_c -->
+<g id="edge17" class="edge">
+<title>e_4_center&#45;&gt;icit_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M454.15,-1243.56C476.49,-1256.27 591.98,-1322.03 643.43,-1351.33"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3" points="641.83,-1354.44 652.25,-1356.35 645.29,-1348.36 641.83,-1354.44"/>
+</g>
+<!-- ac_e -->
+<g id="node20" class="node">
+<title>ac_e</title>
+<ellipse fill="none" stroke="black" cx="406.26" cy="-1866.13" rx="18" ry="18"/>
+<text text-anchor="middle" x="406.26" y="-1862.43" font-family="Times,serif" font-size="14.00">ac_e</text>
+</g>
+<!-- e_5_center -->
+<g id="node22" class="node">
+<title>e_5_center</title>
+<polygon fill="none" stroke="black" points="641.65,-1579.97 634.65,-1579.97 634.65,-1572.97 641.65,-1572.97 641.65,-1579.97"/>
+</g>
+<!-- ac_e&#45;&gt;e_5_center -->
+<g id="edge18" class="edge">
+<title>ac_e&#45;&gt;e_5_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M417.76,-1851.77C460.9,-1797.89 611.8,-1609.39 635.11,-1580.26"/>
+</g>
+<!-- e_19_target -->
+<g id="node63" class="node">
+<title>e_19_target</title>
+<ellipse fill="black" stroke="black" cx="236.03" cy="-2074.13" rx="1.8" ry="1.8"/>
+</g>
+<!-- ac_e&#45;&gt;e_19_target -->
+<g id="edge98" class="edge">
+<title>ac_e&#45;&gt;e_19_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M394.83,-1880.1C362.54,-1919.55 271.24,-2031.11 243.88,-2064.55"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="241.02,-2062.51 237.4,-2072.47 246.44,-2066.95 241.02,-2062.51"/>
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+<!-- h_e -->
+<g id="node21" class="node">
+<title>h_e</title>
+<ellipse fill="none" stroke="black" cx="917.98" cy="-1515.32" rx="18" ry="18"/>
+<text text-anchor="middle" x="917.98" y="-1511.62" font-family="Times,serif" font-size="14.00">h_e</text>
+</g>
+<!-- h_e&#45;&gt;e_5_center -->
+<g id="edge19" class="edge">
+<title>h_e&#45;&gt;e_5_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M900.03,-1518.05C866.5,-1523.28 792.2,-1535.48 730.49,-1550 695.75,-1558.17 654.56,-1571.18 641.98,-1575.23"/>
+</g>
+<!-- e_8_center -->
+<g id="node30" class="node">
+<title>e_8_center</title>
+<polygon fill="none" stroke="black" points="1208.84,-1472.44 1201.84,-1472.44 1201.84,-1465.44 1208.84,-1465.44 1208.84,-1472.44"/>
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+<!-- h_e&#45;&gt;e_8_center -->
+<g id="edge32" class="edge">
+<title>h_e&#45;&gt;e_8_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M935.45,-1510.95C974.15,-1501.5 1070.18,-1479.27 1152.03,-1470.37 1170.62,-1468.35 1193.06,-1468.63 1201.7,-1468.84"/>
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+<!-- h_e&#45;&gt;e_11_center -->
+<g id="edge46" class="edge">
+<title>h_e&#45;&gt;e_11_center</title>
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+<!-- e_16_center -->
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+<title>e_16_center</title>
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+<!-- h_e&#45;&gt;e_16_center -->
+<g id="edge88" class="edge">
+<title>h_e&#45;&gt;e_16_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M933.56,-1524.36C977.24,-1549.71 1099.16,-1620.46 1121.63,-1633.5"/>
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+<!-- e_18_center -->
+<g id="node62" class="node">
+<title>e_18_center</title>
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+<!-- h_e&#45;&gt;e_18_center -->
+<g id="edge94" class="edge">
+<title>h_e&#45;&gt;e_18_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M930.68,-1528.14C964.16,-1561.93 1053.58,-1652.19 1072.74,-1671.53"/>
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+<!-- e_30_target -->
+<g id="node80" class="node">
+<title>e_30_target</title>
+<ellipse fill="black" stroke="black" cx="998.28" cy="-1791.02" rx="1.8" ry="1.8"/>
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+<!-- h_e&#45;&gt;e_30_target -->
+<g id="edge109" class="edge">
+<title>h_e&#45;&gt;e_30_target</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.64" d="M923.13,-1532.99C938.22,-1584.8 982.1,-1735.44 994.8,-1779.06"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.64" points="990.94,-1780.32 997.64,-1788.79 998.74,-1778.05 990.94,-1780.32"/>
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+<!-- e_41_center -->
+<g id="node101" class="node">
+<title>e_41_center</title>
+<polygon fill="none" stroke="black" points="623.85,-1525.03 616.85,-1525.03 616.85,-1518.03 623.85,-1518.03 623.85,-1525.03"/>
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+<!-- h_e&#45;&gt;e_41_center -->
+<g id="edge126" class="edge">
+<title>h_e&#45;&gt;e_41_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M899.81,-1515.7C840.24,-1516.95 653,-1520.85 624.11,-1521.45"/>
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+<!-- e_46_center -->
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+<!-- h_e&#45;&gt;e_46_center -->
+<g id="edge141" class="edge">
+<title>h_e&#45;&gt;e_46_center</title>
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+<!-- e_55_center -->
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+<!-- h_e&#45;&gt;e_55_center -->
+<g id="edge191" class="edge">
+<title>h_e&#45;&gt;e_55_center</title>
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+<!-- e_62_center -->
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+<!-- h_e&#45;&gt;e_62_center -->
+<g id="edge220" class="edge">
+<title>h_e&#45;&gt;e_62_center</title>
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+<!-- e_77_center -->
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+<!-- h_e&#45;&gt;e_77_center -->
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+<title>h_e&#45;&gt;e_77_center</title>
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+<!-- e_83_center -->
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+<!-- h_e&#45;&gt;e_83_center -->
+<g id="edge308" class="edge">
+<title>h_e&#45;&gt;e_83_center</title>
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+<!-- e_86_center -->
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+<!-- h_e&#45;&gt;e_86_center -->
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+<title>h_e&#45;&gt;e_86_center</title>
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+<!-- e_87_center -->
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+<!-- h_e&#45;&gt;e_87_center -->
+<g id="edge317" class="edge">
+<title>h_e&#45;&gt;e_87_center</title>
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+</g>
+<!-- h_e&#45;&gt;e_91_center -->
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+<title>h_e&#45;&gt;e_91_center</title>
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+</g>
+<!-- e_5_center&#45;&gt;h_c -->
+<g id="edge21" class="edge">
+<title>e_5_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M642.01,-1572.71C669.21,-1546.19 832.53,-1387.01 890.78,-1330.22"/>
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+<!-- e_5_center&#45;&gt;ac_c -->
+<g id="edge20" class="edge">
+<title>e_5_center&#45;&gt;ac_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M634.39,-1573.37C611.76,-1554.69 493.04,-1456.68 443.38,-1415.69"/>
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+<!-- amp_c -->
+<g id="node23" class="node">
+<title>amp_c</title>
+<ellipse fill="none" stroke="black" cx="426.43" cy="-860.23" rx="18" ry="18"/>
+<text text-anchor="middle" x="426.43" y="-856.53" font-family="Times,serif" font-size="14.00">amp_c</text>
+</g>
+<!-- amp_c&#45;&gt;e_6_center -->
+<g id="edge23" class="edge">
+<title>amp_c&#45;&gt;e_6_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M442.75,-868.63C466.44,-880.81 508.9,-902.64 521.59,-909.17"/>
+</g>
+<!-- e_6_center&#45;&gt;adp_c -->
+<g id="edge24" class="edge">
+<title>e_6_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M528.93,-912.87C548.85,-922.72 645.04,-970.3 691.66,-993.37"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="690.3,-996.6 700.81,-997.89 693.4,-990.32 690.3,-996.6"/>
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+<!-- akg_c -->
+<g id="node25" class="node">
+<title>akg_c</title>
+<ellipse fill="none" stroke="black" cx="1166.85" cy="-1189.81" rx="18" ry="18"/>
+<text text-anchor="middle" x="1166.85" y="-1186.11" font-family="Times,serif" font-size="14.00">akg_c</text>
+</g>
+<!-- akg_c&#45;&gt;e_7_center -->
+<g id="edge27" class="edge">
+<title>akg_c&#45;&gt;e_7_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M1149.81,-1196.6C1130.45,-1204.31 1100.24,-1216.35 1090,-1220.43"/>
+</g>
+<!-- akg_c&#45;&gt;e_54_center -->
+<g id="edge188" class="edge">
+<title>akg_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1153.82,-1176.86C1135.84,-1159 1104.43,-1127.8 1093.73,-1117.17"/>
+</g>
+<!-- co2_c -->
+<g id="node26" class="node">
+<title>co2_c</title>
+<ellipse fill="none" stroke="black" cx="1132.22" cy="-954.15" rx="18" ry="18"/>
+<text text-anchor="middle" x="1132.22" y="-950.45" font-family="Times,serif" font-size="14.00">co2_c</text>
+</g>
+<!-- co2_c&#45;&gt;e_78_center -->
+<g id="edge280" class="edge">
+<title>co2_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.66" d="M1115.28,-960.42C1104.12,-964.48 1089.17,-969.79 1075.82,-974.08 999.73,-998.5 905.35,-1023.92 885.61,-1029.19"/>
+</g>
+<!-- succoa_c -->
+<g id="node27" class="node">
+<title>succoa_c</title>
+<ellipse fill="none" stroke="black" cx="946.22" cy="-1392.43" rx="18" ry="18"/>
+<text text-anchor="middle" x="946.22" y="-1388.73" font-family="Times,serif" font-size="14.00">succoa_c</text>
+</g>
+<!-- e_7_center&#45;&gt;nadh_c -->
+<g id="edge29" class="edge">
+<title>e_7_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M1082.78,-1219.98C1080.07,-1218.61 1076.12,-1216.62 1071.82,-1214.45"/>
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+</g>
+<!-- e_7_center&#45;&gt;co2_c -->
+<g id="edge28" class="edge">
+<title>e_7_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M1084.75,-1218.11C1081.66,-1211.05 1075.55,-1195.19 1076.08,-1181.22 1077.16,-1152.61 1089.14,-1147.8 1096.73,-1120.2 1109.92,-1072.24 1121.14,-1015.36 1127.26,-982.16"/>
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+<!-- e_7_center&#45;&gt;succoa_c -->
+<g id="edge30" class="edge">
+<title>e_7_center&#45;&gt;succoa_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M1084.1,-1225.65C1073.99,-1241.74 1033.17,-1305.38 991.77,-1351.28 984.64,-1359.18 976.14,-1367.18 968.42,-1374"/>
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+<!-- akg_e -->
+<g id="node29" class="node">
+<title>akg_e</title>
+<ellipse fill="none" stroke="black" cx="1509.21" cy="-1660.96" rx="18" ry="18"/>
+<text text-anchor="middle" x="1509.21" y="-1657.26" font-family="Times,serif" font-size="14.00">akg_e</text>
+</g>
+<!-- akg_e&#45;&gt;e_8_center -->
+<g id="edge31" class="edge">
+<title>akg_e&#45;&gt;e_8_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1493.72,-1651.17C1436.39,-1614.95 1238.05,-1489.61 1208.92,-1471.21"/>
+</g>
+<!-- e_21_target -->
+<g id="node65" class="node">
+<title>e_21_target</title>
+<ellipse fill="black" stroke="black" cx="1735.18" cy="-1802.02" rx="1.8" ry="1.8"/>
+</g>
+<!-- akg_e&#45;&gt;e_21_target -->
+<g id="edge100" class="edge">
+<title>akg_e&#45;&gt;e_21_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1524.74,-1670.66C1567.93,-1697.62 1688.64,-1772.97 1724.81,-1795.55"/>
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+</g>
+<!-- e_8_center&#45;&gt;h_c -->
+<g id="edge33" class="edge">
+<title>e_8_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1201.79,-1467.54C1179.41,-1458.65 1055.75,-1408.52 964.05,-1351.22 953.36,-1344.54 942.25,-1336.12 933.02,-1328.64"/>
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+<!-- e_8_center&#45;&gt;akg_c -->
+<g id="edge34" class="edge">
+<title>e_8_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1204.85,-1465.41C1201.33,-1439.89 1179.66,-1282.69 1170.71,-1217.79"/>
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+<!-- etoh_c -->
+<g id="node31" class="node">
+<title>etoh_c</title>
+<ellipse fill="none" stroke="black" cx="1289.88" cy="-1612.42" rx="18" ry="18"/>
+<text text-anchor="middle" x="1289.88" y="-1608.72" font-family="Times,serif" font-size="14.00">etoh_c</text>
+</g>
+<!-- etoh_c&#45;&gt;e_9_center -->
+<g id="edge35" class="edge">
+<title>etoh_c&#45;&gt;e_9_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1284.84,-1594.84C1269.92,-1542.83 1226.58,-1391.74 1219.24,-1366.16"/>
+</g>
+<!-- e_9_center&#45;&gt;acald_c -->
+<g id="edge38" class="edge">
+<title>e_9_center&#45;&gt;acald_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1222.03,-1362.65C1246.16,-1363.89 1377.16,-1370.59 1435.58,-1373.58"/>
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+</g>
+<!-- e_9_center&#45;&gt;nadh_c -->
+<g id="edge37" class="edge">
+<title>e_9_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1214.67,-1358.64C1202.43,-1345.38 1160.37,-1300.26 1122.97,-1265.75 1113.15,-1256.69 1087.41,-1235.3 1068.48,-1219.72"/>
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+</g>
+<!-- e_9_center&#45;&gt;h_c -->
+<g id="edge39" class="edge">
+<title>e_9_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1214.52,-1361.68C1192.47,-1357.01 1074.87,-1332.37 977.98,-1317.79 965.47,-1315.91 951.58,-1314.24 939.74,-1312.95"/>
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+</g>
+<!-- pi_c -->
+<g id="node33" class="node">
+<title>pi_c</title>
+<ellipse fill="none" stroke="black" cx="774.55" cy="-1104.66" rx="18" ry="18"/>
+<text text-anchor="middle" x="774.55" y="-1100.96" font-family="Times,serif" font-size="14.00">pi_c</text>
+</g>
+<!-- pi_c&#45;&gt;e_11_center -->
+<g id="edge45" class="edge">
+<title>pi_c&#45;&gt;e_11_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M775.68,-1122.88C777.72,-1155.94 781.91,-1223.9 782.93,-1240.38"/>
+</g>
+<!-- pi_c&#45;&gt;e_48_center -->
+<g id="edge150" class="edge">
+<title>pi_c&#45;&gt;e_48_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.51" d="M792.07,-1099.39C806.52,-1094.63 827.22,-1086.81 843.61,-1076.65 903.33,-1039.62 958.93,-972.19 971.89,-955.91"/>
+</g>
+<!-- pi_c&#45;&gt;e_81_center -->
+<g id="edge299" class="edge">
+<title>pi_c&#45;&gt;e_81_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M756.7,-1107.12C715.56,-1112.8 616.07,-1126.54 595.54,-1129.38"/>
+</g>
+<!-- e_10_center&#45;&gt;h_c -->
+<g id="edge43" class="edge">
+<title>e_10_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.51" d="M711.92,-1182.98C732.59,-1196.16 838.91,-1263.91 887.33,-1294.77"/>
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+<!-- e_10_center&#45;&gt;adp_c -->
+<g id="edge44" class="edge">
+<title>e_10_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.51" d="M707.75,-1177.07C705.16,-1161.57 695.84,-1099.88 702.72,-1049.86 703.51,-1044.1 705.01,-1038.08 706.75,-1032.41"/>
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+</g>
+<!-- e_10_center&#45;&gt;pi_c -->
+<g id="edge42" class="edge">
+<title>e_10_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.51" d="M711.88,-1177.17C717.92,-1170.97 730.63,-1157.76 740.82,-1146.09 746.11,-1140.04 751.68,-1133.34 756.73,-1127.12"/>
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+<!-- e_11_center&#45;&gt;h_c -->
+<g id="edge50" class="edge">
+<title>e_11_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M786.86,-1245.94C801.22,-1253.34 854.1,-1280.59 886.16,-1297.1"/>
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+</g>
+<!-- e_11_center&#45;&gt;atp_c -->
+<g id="edge48" class="edge">
+<title>e_11_center&#45;&gt;atp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M781.99,-1240.33C775.74,-1220.36 745.74,-1124.69 730.8,-1077.06"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="734.94,-1075.63 727.77,-1067.39 726.59,-1078.25 734.94,-1075.63"/>
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+<!-- e_11_center&#45;&gt;h2o_c -->
+<g id="edge49" class="edge">
+<title>e_11_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M781.29,-1240.31C774.92,-1227.64 753.68,-1185.38 739.73,-1157.61"/>
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+<!-- nadph_c -->
+<g id="node36" class="node">
+<title>nadph_c</title>
+<ellipse fill="none" stroke="black" cx="1159.98" cy="-1014.03" rx="18" ry="18"/>
+<text text-anchor="middle" x="1159.98" y="-1010.33" font-family="Times,serif" font-size="14.00">nadph_c</text>
+</g>
+<!-- nadph_c&#45;&gt;e_12_center -->
+<g id="edge51" class="edge">
+<title>nadph_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M1143.23,-1007.27C1102.04,-990.7 998.02,-949.16 981.42,-945.6 971.58,-943.49 959.63,-943.49 953.69,-943.66"/>
+</g>
+<!-- nadph_c&#45;&gt;e_54_center -->
+<g id="edge186" class="edge">
+<title>nadph_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1149.36,-1029.14C1132.85,-1052.62 1101.96,-1096.53 1092.71,-1109.68"/>
+</g>
+<!-- nadph_c&#45;&gt;e_67_center -->
+<g id="edge245" class="edge">
+<title>nadph_c&#45;&gt;e_67_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1175.22,-1024.3C1184.89,-1031.13 1197.42,-1040.58 1207.46,-1050.17 1237.21,-1078.6 1266.83,-1118.9 1275.75,-1131.36"/>
+</g>
+<!-- g3p_c -->
+<g id="node37" class="node">
+<title>g3p_c</title>
+<ellipse fill="none" stroke="black" cx="1021.46" cy="-580.96" rx="18" ry="18"/>
+<text text-anchor="middle" x="1021.46" y="-577.26" font-family="Times,serif" font-size="14.00">g3p_c</text>
+</g>
+<!-- g3p_c&#45;&gt;e_12_center -->
+<g id="edge52" class="edge">
+<title>g3p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M1017.92,-598.95C1004.5,-667.02 957.29,-906.6 950.72,-939.95"/>
+</g>
+<!-- g3p_c&#45;&gt;e_48_center -->
+<g id="edge152" class="edge">
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+<!-- g3p_c&#45;&gt;e_90_center -->
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+<!-- glu__L_c -->
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+<!-- glu__L_c&#45;&gt;e_12_center -->
+<g id="edge53" class="edge">
+<title>glu__L_c&#45;&gt;e_12_center</title>
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+<!-- glu__L_c&#45;&gt;e_50_center -->
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+<!-- glu__L_c&#45;&gt;e_52_center -->
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+<!-- oaa_c -->
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+<title>oaa_c</title>
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+</g>
+<!-- oaa_c&#45;&gt;e_12_center -->
+<g id="edge54" class="edge">
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+<!-- oaa_c&#45;&gt;e_14_center -->
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+<!-- oaa_c&#45;&gt;e_79_center -->
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+<!-- pyr_c -->
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+<!-- pyr_c&#45;&gt;e_12_center -->
+<g id="edge55" class="edge">
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+<!-- pyr_c&#45;&gt;e_70_center -->
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+<!-- pyr_c&#45;&gt;e_72_center -->
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+<!-- pyr_c&#45;&gt;e_80_center -->
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+<!-- e4p_c -->
+<g id="node41" class="node">
+<title>e4p_c</title>
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+</g>
+<!-- e4p_c&#45;&gt;e_12_center -->
+<g id="edge56" class="edge">
+<title>e4p_c&#45;&gt;e_12_center</title>
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+<!-- e_93_center -->
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+<!-- e4p_c&#45;&gt;e_93_center -->
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+<title>e4p_c&#45;&gt;e_93_center</title>
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+<!-- r5p_c -->
+<g id="node42" class="node">
+<title>r5p_c</title>
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+</g>
+<!-- r5p_c&#45;&gt;e_12_center -->
+<g id="edge57" class="edge">
+<title>r5p_c&#45;&gt;e_12_center</title>
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+<!-- ru5p__D_c -->
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+<title>ru5p__D_c</title>
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+</g>
+<!-- r5p_c&#45;&gt;ru5p__D_c -->
+<g id="edge312" class="edge">
+<title>r5p_c&#45;&gt;ru5p__D_c</title>
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+<!-- e_92_center -->
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+<!-- r5p_c&#45;&gt;e_92_center -->
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+<title>r5p_c&#45;&gt;e_92_center</title>
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+</g>
+<!-- gln__L_c -->
+<g id="node43" class="node">
+<title>gln__L_c</title>
+<ellipse fill="none" stroke="black" cx="876.28" cy="-969.94" rx="18" ry="18"/>
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+</g>
+<!-- gln__L_c&#45;&gt;e_12_center -->
+<g id="edge59" class="edge">
+<title>gln__L_c&#45;&gt;e_12_center</title>
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+<!-- gln__L_c&#45;&gt;e_53_center -->
+<g id="edge182" class="edge">
+<title>gln__L_c&#45;&gt;e_53_center</title>
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+<!-- gln__L_c&#45;&gt;e_54_center -->
+<g id="edge187" class="edge">
+<title>gln__L_c&#45;&gt;e_54_center</title>
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+<!-- g6p_c -->
+<g id="node44" class="node">
+<title>g6p_c</title>
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+</g>
+<!-- f6p_c -->
+<g id="node46" class="node">
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+</g>
+<!-- g6p_c&#45;&gt;f6p_c -->
+<g id="edge266" class="edge">
+<title>g6p_c&#45;&gt;f6p_c</title>
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+<!-- g6p_c&#45;&gt;e_12_center -->
+<g id="edge60" class="edge">
+<title>g6p_c&#45;&gt;e_12_center</title>
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+<!-- e_47_center -->
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+<!-- g6p_c&#45;&gt;e_47_center -->
+<g id="edge146" class="edge">
+<title>g6p_c&#45;&gt;e_47_center</title>
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+<!-- pep_c -->
+<g id="node45" class="node">
+<title>pep_c</title>
+<ellipse fill="none" stroke="black" cx="744.99" cy="-829.05" rx="18" ry="18"/>
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+<!-- pep_c&#45;&gt;e_12_center -->
+<g id="edge61" class="edge">
+<title>pep_c&#45;&gt;e_12_center</title>
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+<!-- e_44_center -->
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+<!-- pep_c&#45;&gt;e_44_center -->
+<g id="edge135" class="edge">
+<title>pep_c&#45;&gt;e_44_center</title>
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+<!-- e_49_center -->
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+<!-- pep_c&#45;&gt;e_49_center -->
+<g id="edge157" class="edge">
+<title>pep_c&#45;&gt;e_49_center</title>
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+<!-- pep_c&#45;&gt;e_78_center -->
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+<!-- pep_c&#45;&gt;e_82_center -->
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+<!-- f6p_c&#45;&gt;e_12_center -->
+<g id="edge64" class="edge">
+<title>f6p_c&#45;&gt;e_12_center</title>
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+<!-- f6p_c&#45;&gt;e_71_center -->
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+<!-- 3pg_c -->
+<g id="node47" class="node">
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+</g>
+<!-- 3pg_c&#45;&gt;e_12_center -->
+<g id="edge65" class="edge">
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+<!-- 3pg_c&#45;&gt;e_74_center -->
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+<title>3pg_c&#45;&gt;e_74_center</title>
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+<!-- nadp_c -->
+<g id="node48" class="node">
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+<ellipse fill="none" stroke="black" cx="1193.56" cy="-1063.99" rx="18" ry="18"/>
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+<!-- nadp_c&#45;&gt;e_47_center -->
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+<!-- nadp_c&#45;&gt;e_52_center -->
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+<!-- e_56_center -->
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+<!-- nadp_c&#45;&gt;e_56_center -->
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+<!-- nadp_c&#45;&gt;e_58_center -->
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+<!-- nadp_c&#45;&gt;e_65_center -->
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+<!-- nadp_c&#45;&gt;e_91_center -->
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+<!-- e_12_center&#45;&gt;coa_c -->
+<g id="edge72" class="edge">
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+<!-- e_12_center&#45;&gt;nadh_c -->
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+<!-- e_12_center&#45;&gt;h_c -->
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+<!-- e_12_center&#45;&gt;adp_c -->
+<g id="edge73" class="edge">
+<title>e_12_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M946.22,-943.76C935.3,-943.67 902.55,-943.99 876.37,-950.34 835.16,-960.34 834.83,-987.66 793.7,-997.97 778.09,-1001.88 760.24,-1003.88 745.69,-1004.9"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="0.46" points="745.09,-1001.43 735.31,-1005.5 745.49,-1008.41 745.09,-1001.43"/>
+</g>
+<!-- e_12_center&#45;&gt;akg_c -->
+<g id="edge71" class="edge">
+<title>e_12_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M953.2,-947.34C969.09,-964.58 1040.16,-1041.95 1096.73,-1106.8 1114.58,-1127.26 1134.52,-1150.95 1148.56,-1167.77"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="0.46" points="1146.23,-1170.45 1155.32,-1175.89 1151.61,-1165.97 1146.23,-1170.45"/>
+</g>
+<!-- e_12_center&#45;&gt;pi_c -->
+<g id="edge69" class="edge">
+<title>e_12_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M946.37,-946.11C930.12,-956.57 862.24,-1001.37 816.08,-1048.74 806.68,-1058.39 797.6,-1070.23 790.34,-1080.52"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="0.46" points="787.24,-1078.85 784.46,-1089.08 793.01,-1082.81 787.24,-1078.85"/>
+</g>
+<!-- e_12_center&#45;&gt;nadp_c -->
+<g id="edge67" class="edge">
+<title>e_12_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M953.61,-947.39C957.11,-950.68 962.63,-955.57 968.02,-959 1035.47,-1001.97 1123.33,-1037.7 1166.8,-1054.19"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="0.46" points="1165.77,-1057.54 1176.36,-1057.78 1168.23,-1050.99 1165.77,-1057.54"/>
+</g>
+<!-- co2_e -->
+<g id="node50" class="node">
+<title>co2_e</title>
+<ellipse fill="none" stroke="black" cx="1465.37" cy="-728.13" rx="18" ry="18"/>
+<text text-anchor="middle" x="1465.37" y="-724.43" font-family="Times,serif" font-size="14.00">co2_e</text>
+</g>
+<!-- co2_e&#45;&gt;co2_c -->
+<g id="edge74" class="edge">
+<title>co2_e&#45;&gt;co2_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.96" d="M1450.19,-738.43C1397.18,-774.39 1220.07,-894.55 1155.78,-938.16"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.96" points="1153.8,-935.28 1147.49,-943.79 1157.73,-941.07 1153.8,-935.28"/>
+</g>
+<!-- e_22_target -->
+<g id="node66" class="node">
+<title>e_22_target</title>
+<ellipse fill="black" stroke="black" cx="1684.99" cy="-570.23" rx="1.8" ry="1.8"/>
+</g>
+<!-- co2_e&#45;&gt;e_22_target -->
+<g id="edge101" class="edge">
+<title>co2_e&#45;&gt;e_22_target</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1480.12,-717.53C1521.78,-687.58 1639.56,-602.89 1674.87,-577.51"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="1677.66,-580.89 1683.23,-571.5 1672.56,-573.78 1677.66,-580.89"/>
+</g>
+<!-- e_14_center&#45;&gt;coa_c -->
+<g id="edge79" class="edge">
+<title>e_14_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M664.65,-1218.4C684.32,-1217.45 777.85,-1212.94 825.65,-1210.64"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3" points="825.84,-1214.13 835.66,-1210.16 825.5,-1207.14 825.84,-1214.13"/>
+</g>
+<!-- e_14_center&#45;&gt;h_c -->
+<g id="edge80" class="edge">
+<title>e_14_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M664.51,-1219.87C688.29,-1228.57 825.6,-1278.75 884.55,-1300.29"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3" points="883.68,-1303.7 894.27,-1303.85 886.08,-1297.13 883.68,-1303.7"/>
+</g>
+<!-- e_14_center&#45;&gt;cit_c -->
+<g id="edge78" class="edge">
+<title>e_14_center&#45;&gt;cit_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M657.42,-1218.34C648.96,-1217.82 626.98,-1216.66 608.64,-1217.46 531.74,-1220.86 441.4,-1230.33 396.58,-1235.4"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3" points="396,-1231.94 386.46,-1236.56 396.79,-1238.9 396,-1231.94"/>
+</g>
+<!-- o2_c -->
+<g id="node52" class="node">
+<title>o2_c</title>
+<ellipse fill="none" stroke="black" cx="558.29" cy="-1940.84" rx="18" ry="18"/>
+<text text-anchor="middle" x="558.29" y="-1937.14" font-family="Times,serif" font-size="14.00">o2_c</text>
+</g>
+<!-- o2_c&#45;&gt;e_15_center -->
+<g id="edge81" class="edge">
+<title>o2_c&#45;&gt;e_15_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M565.98,-1924.34C597.95,-1855.69 719.45,-1594.79 735.45,-1560.44"/>
+</g>
+<!-- q8h2_c -->
+<g id="node53" class="node">
+<title>q8h2_c</title>
+<ellipse fill="none" stroke="black" cx="795.16" cy="-1726.84" rx="18" ry="18"/>
+<text text-anchor="middle" x="795.16" y="-1723.14" font-family="Times,serif" font-size="14.00">q8h2_c</text>
+</g>
+<!-- q8h2_c&#45;&gt;e_15_center -->
+<g id="edge82" class="edge">
+<title>q8h2_c&#45;&gt;e_15_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M789.29,-1709.59C776.16,-1671.06 745.09,-1579.89 738.45,-1560.4"/>
+</g>
+<!-- e_43_center -->
+<g id="node104" class="node">
+<title>e_43_center</title>
+<polygon fill="none" stroke="black" points="720.64,-1865.62 713.64,-1865.62 713.64,-1858.62 720.64,-1858.62 720.64,-1865.62"/>
+</g>
+<!-- q8h2_c&#45;&gt;e_43_center -->
+<g id="edge130" class="edge">
+<title>q8h2_c&#45;&gt;e_43_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M786.06,-1742.62C768.05,-1773.85 728.79,-1841.92 719.26,-1858.45"/>
+</g>
+<!-- q8_c -->
+<g id="node54" class="node">
+<title>q8_c</title>
+<ellipse fill="none" stroke="black" cx="845.94" cy="-1731.79" rx="18" ry="18"/>
+<text text-anchor="middle" x="845.94" y="-1728.09" font-family="Times,serif" font-size="14.00">q8_c</text>
+</g>
+<!-- q8_c&#45;&gt;e_66_center -->
+<g id="edge239" class="edge">
+<title>q8_c&#45;&gt;e_66_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M853.61,-1715.37C877.87,-1663.45 952.02,-1504.74 964.02,-1479.05"/>
+</g>
+<!-- e_88_center -->
+<g id="node150" class="node">
+<title>e_88_center</title>
+<polygon fill="none" stroke="black" points="763.01,-1882.78 756.01,-1882.78 756.01,-1875.78 763.01,-1875.78 763.01,-1882.78"/>
+</g>
+<!-- q8_c&#45;&gt;e_88_center -->
+<g id="edge321" class="edge">
+<title>q8_c&#45;&gt;e_88_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M831.85,-1743.51C825.45,-1749.33 818.12,-1756.74 812.72,-1764.4 784.85,-1803.92 765.58,-1860.36 760.72,-1875.45"/>
+</g>
+<!-- e_15_center&#45;&gt;h2o_c -->
+<g id="edge86" class="edge">
+<title>e_15_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M737.1,-1553.03C736.27,-1518.45 729.79,-1249.23 727.65,-1160.49"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="732.02,-1160.25 727.41,-1150.36 723.28,-1160.46 732.02,-1160.25"/>
+</g>
+<!-- e_15_center&#45;&gt;h_e -->
+<g id="edge85" class="edge">
+<title>e_15_center&#45;&gt;h_e</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M740.97,-1555.83C759.93,-1551.49 845.65,-1531.88 890.47,-1521.62"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="891.64,-1525.84 900.41,-1519.35 889.69,-1517.31 891.64,-1525.84"/>
+</g>
+<!-- e_15_center&#45;&gt;q8_c -->
+<g id="edge84" class="edge">
+<title>e_15_center&#45;&gt;q8_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M739.46,-1560.36C751.11,-1579.11 804.64,-1665.3 831.08,-1707.87"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="827.45,-1710.3 836.44,-1716.49 834.88,-1705.69 827.45,-1710.3"/>
+</g>
+<!-- lac__D_e -->
+<g id="node56" class="node">
+<title>lac__D_e</title>
+<ellipse fill="none" stroke="black" cx="1328.12" cy="-1933.24" rx="18" ry="18"/>
+<text text-anchor="middle" x="1328.12" y="-1929.54" font-family="Times,serif" font-size="14.00">lac__D_e</text>
+</g>
+<!-- lac__D_e&#45;&gt;e_16_center -->
+<g id="edge87" class="edge">
+<title>lac__D_e&#45;&gt;e_16_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1317.78,-1918.07C1279.5,-1861.92 1147.06,-1667.62 1127.61,-1639.09"/>
+</g>
+<!-- e_32_target -->
+<g id="node83" class="node">
+<title>e_32_target</title>
+<ellipse fill="black" stroke="black" cx="1480.69" cy="-2153.52" rx="1.8" ry="1.8"/>
+</g>
+<!-- lac__D_e&#45;&gt;e_32_target -->
+<g id="edge111" class="edge">
+<title>lac__D_e&#45;&gt;e_32_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1338.61,-1948.38C1367.77,-1990.49 1449.27,-2108.16 1473.69,-2143.42"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1470.9,-2145.54 1479.47,-2151.77 1476.65,-2141.55 1470.9,-2145.54"/>
+</g>
+<!-- lac__D_c -->
+<g id="node57" class="node">
+<title>lac__D_c</title>
+<ellipse fill="none" stroke="black" cx="1151.88" cy="-1489.97" rx="18" ry="18"/>
+<text text-anchor="middle" x="1151.88" y="-1486.27" font-family="Times,serif" font-size="14.00">lac__D_c</text>
+</g>
+<!-- lac__D_c&#45;&gt;e_60_center -->
+<g id="edge209" class="edge">
+<title>lac__D_c&#45;&gt;e_60_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1141.63,-1474.72C1110.02,-1427.66 1015.11,-1286.36 998.32,-1261.35"/>
+</g>
+<!-- e_16_center&#45;&gt;h_c -->
+<g id="edge90" class="edge">
+<title>e_16_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1122.95,-1631.92C1108.63,-1608.77 1029.03,-1480.52 960.11,-1378.6 949.75,-1363.28 937.71,-1346.34 928.2,-1333.15"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="930.76,-1330.72 922.06,-1324.67 925.09,-1334.82 930.76,-1330.72"/>
+</g>
+<!-- e_16_center&#45;&gt;lac__D_c -->
+<g id="edge89" class="edge">
+<title>e_16_center&#45;&gt;lac__D_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1125.88,-1631.98C1128.71,-1616.52 1140,-1554.83 1146.74,-1518.03"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1150.23,-1518.4 1148.59,-1507.94 1143.34,-1517.14 1150.23,-1518.4"/>
+</g>
+<!-- 2pg_c -->
+<g id="node59" class="node">
+<title>2pg_c</title>
+<ellipse fill="none" stroke="black" cx="497.28" cy="-600.44" rx="18" ry="18"/>
+<text text-anchor="middle" x="497.28" y="-596.74" font-family="Times,serif" font-size="14.00">2pg_c</text>
+</g>
+<!-- 2pg_c&#45;&gt;3pg_c -->
+<g id="edge275" class="edge">
+<title>2pg_c&#45;&gt;3pg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.96" d="M513.85,-608.07C552.75,-625.99 650.17,-670.87 696.86,-692.38"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.96" points="695.47,-695.59 706.02,-696.6 698.4,-689.24 695.47,-695.59"/>
+</g>
+<!-- e_17_center -->
+<g id="node60" class="node">
+<title>e_17_center</title>
+<polygon fill="none" stroke="black" points="571.44,-825.54 564.44,-825.54 564.44,-818.54 571.44,-818.54 571.44,-825.54"/>
+</g>
+<!-- 2pg_c&#45;&gt;e_17_center -->
+<g id="edge91" class="edge">
+<title>2pg_c&#45;&gt;e_17_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.38" d="M502.82,-617.83C517.92,-665.17 559.14,-794.42 566.73,-818.24"/>
+</g>
+<!-- e_17_center&#45;&gt;h2o_c -->
+<g id="edge93" class="edge">
+<title>e_17_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.38" d="M569.97,-825.72C580.7,-845.2 631.92,-938.52 671.21,-1016.18 686.75,-1046.9 703.77,-1082.65 714.87,-1106.27"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.38" points="711.53,-1108.16 719.24,-1115.59 718.47,-1104.91 711.53,-1108.16"/>
+</g>
+<!-- e_17_center&#45;&gt;pep_c -->
+<g id="edge92" class="edge">
+<title>e_17_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.38" d="M571.64,-822.19C590.04,-822.92 672.56,-826.18 716.78,-827.93"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.38" points="716.74,-831.76 726.88,-828.33 717.04,-824.11 716.74,-831.76"/>
+</g>
+<!-- etoh_e -->
+<g id="node61" class="node">
+<title>etoh_e</title>
+<ellipse fill="none" stroke="black" cx="1127.45" cy="-2036.97" rx="18" ry="18"/>
+<text text-anchor="middle" x="1127.45" y="-2033.27" font-family="Times,serif" font-size="14.00">etoh_e</text>
+</g>
+<!-- etoh_e&#45;&gt;e_18_center -->
+<g id="edge95" class="edge">
+<title>etoh_e&#45;&gt;e_18_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1124.92,-2019.03C1115.34,-1951.17 1081.63,-1712.31 1076.93,-1679.06"/>
+</g>
+<!-- e_23_target -->
+<g id="node67" class="node">
+<title>e_23_target</title>
+<ellipse fill="black" stroke="black" cx="1179.89" cy="-2295.78" rx="1.8" ry="1.8"/>
+</g>
+<!-- etoh_e&#45;&gt;e_23_target -->
+<g id="edge102" class="edge">
+<title>etoh_e&#45;&gt;e_23_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1131.06,-2054.76C1141.08,-2104.22 1169.09,-2242.48 1177.48,-2283.9"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1174.05,-2284.61 1179.47,-2293.71 1180.92,-2283.22 1174.05,-2284.61"/>
+</g>
+<!-- e_18_center&#45;&gt;h_c -->
+<g id="edge97" class="edge">
+<title>e_18_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1075.35,-1671.52C1068.01,-1645.9 1022.63,-1491.92 960.11,-1378.6 951.09,-1362.25 938.92,-1345.14 929,-1332.1"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="931.76,-1329.94 922.87,-1324.18 926.22,-1334.23 931.76,-1329.94"/>
+</g>
+<!-- e_18_center&#45;&gt;etoh_c -->
+<g id="edge96" class="edge">
+<title>e_18_center&#45;&gt;etoh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1080.1,-1674.12C1101.54,-1667.81 1210.59,-1635.74 1262.44,-1620.49"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1263.68,-1623.77 1272.29,-1617.59 1261.71,-1617.06 1263.68,-1623.77"/>
+</g>
+<!-- e_24_target -->
+<g id="node68" class="node">
+<title>e_24_target</title>
+<ellipse fill="black" stroke="black" cx="66.67" cy="-1786.44" rx="1.8" ry="1.8"/>
+</g>
+<!-- for_e -->
+<g id="node69" class="node">
+<title>for_e</title>
+<ellipse fill="none" stroke="black" cx="300.68" cy="-1655.94" rx="18" ry="18"/>
+<text text-anchor="middle" x="300.68" y="-1652.24" font-family="Times,serif" font-size="14.00">for_e</text>
+</g>
+<!-- for_e&#45;&gt;e_24_target -->
+<g id="edge103" class="edge">
+<title>for_e&#45;&gt;e_24_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M284.6,-1664.91C239.87,-1689.85 114.86,-1759.57 77.4,-1780.46"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="75.56,-1777.48 68.53,-1785.4 78.97,-1783.59 75.56,-1777.48"/>
+</g>
+<!-- for_e&#45;&gt;e_41_center -->
+<g id="edge125" class="edge">
+<title>for_e&#45;&gt;e_41_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M317.42,-1648.91C378.31,-1623.3 586.09,-1535.94 616.6,-1523.11"/>
+</g>
+<!-- e_25_target -->
+<g id="node70" class="node">
+<title>e_25_target</title>
+<ellipse fill="black" stroke="black" cx="573.51" cy="-1.74" rx="1.8" ry="1.8"/>
+</g>
+<!-- fru_e -->
+<g id="node71" class="node">
+<title>fru_e</title>
+<ellipse fill="none" stroke="black" cx="639.15" cy="-248.46" rx="18" ry="18"/>
+<text text-anchor="middle" x="639.15" y="-244.76" font-family="Times,serif" font-size="14.00">fru_e</text>
+</g>
+<!-- fru_e&#45;&gt;e_25_target -->
+<g id="edge104" class="edge">
+<title>fru_e&#45;&gt;e_25_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M634.43,-230.71C621.75,-183.07 587.21,-53.24 576.63,-13.47"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="579.98,-12.45 574.03,-3.69 573.21,-14.25 579.98,-12.45"/>
+</g>
+<!-- fru_e&#45;&gt;e_44_center -->
+<g id="edge134" class="edge">
+<title>fru_e&#45;&gt;e_44_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M644.05,-266.2C662.27,-332.13 725.48,-560.96 734.27,-592.81"/>
+</g>
+<!-- e_26_target -->
+<g id="node72" class="node">
+<title>e_26_target</title>
+<ellipse fill="black" stroke="black" cx="1276.35" cy="-2268.64" rx="1.8" ry="1.8"/>
+</g>
+<!-- fum_e -->
+<g id="node73" class="node">
+<title>fum_e</title>
+<ellipse fill="none" stroke="black" cx="1172.91" cy="-2025.98" rx="18" ry="18"/>
+<text text-anchor="middle" x="1172.91" y="-2022.28" font-family="Times,serif" font-size="14.00">fum_e</text>
+</g>
+<!-- fum_e&#45;&gt;e_26_target -->
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+<!-- glu__L_e&#45;&gt;e_29_target -->
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+<!-- e_31_target -->
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+<!-- h2o_e&#45;&gt;h2o_c -->
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+<!-- h2o_e&#45;&gt;e_31_target -->
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+<!-- mal__L_e -->
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+<!-- mal__L_e&#45;&gt;e_33_target -->
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+<!-- e_34_target -->
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+<!-- nh4_e -->
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+<!-- nh4_e&#45;&gt;e_34_target -->
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+<!-- nh4_c -->
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+<!-- nh4_e&#45;&gt;nh4_c -->
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+<!-- e_35_target -->
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+<!-- o2_e -->
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+<!-- o2_e&#45;&gt;o2_c -->
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+<!-- e_36_target -->
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+<!-- pi_e -->
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+<!-- pi_e&#45;&gt;e_36_target -->
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+<!-- pi_e&#45;&gt;e_77_center -->
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+<!-- e_37_target -->
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+<!-- pyr_e -->
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+<!-- pyr_e&#45;&gt;e_37_target -->
+<g id="edge116" class="edge">
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+<!-- pyr_e&#45;&gt;e_83_center -->
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+<!-- e_38_target -->
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+<!-- succ_e -->
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+<!-- succ_e&#45;&gt;e_38_target -->
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+<!-- fdp_c -->
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+<!-- e_39_center -->
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+<!-- fdp_c&#45;&gt;e_39_center -->
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+<!-- fdp_c&#45;&gt;e_40_center -->
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+<!-- dhap_c -->
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+<!-- dhap_c&#45;&gt;g3p_c -->
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+<!-- for_c&#45;&gt;for_e -->
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+<!-- fum_c -->
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+<!-- fum_c&#45;&gt;e_43_center -->
+<g id="edge131" class="edge">
+<title>fum_c&#45;&gt;e_43_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M812.15,-1789.34C786.69,-1808.84 734.82,-1848.57 720.74,-1859.36"/>
+</g>
+<!-- fum_c&#45;&gt;e_45_center -->
+<g id="edge139" class="edge">
+<title>fum_c&#45;&gt;e_45_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M825.09,-1760.43C820.48,-1699.33 805.58,-1501.7 803.39,-1472.7"/>
+</g>
+<!-- succ_c -->
+<g id="node103" class="node">
+<title>succ_c</title>
+<ellipse fill="none" stroke="black" cx="717.27" cy="-1656.99" rx="18" ry="18"/>
+<text text-anchor="middle" x="717.27" y="-1653.29" font-family="Times,serif" font-size="14.00">succ_c</text>
+</g>
+<!-- succ_c&#45;&gt;e_87_center -->
+<g id="edge318" class="edge">
+<title>succ_c&#45;&gt;e_87_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M735.49,-1656.71C764.56,-1656.22 823.22,-1654.99 872.89,-1652.5 880.11,-1652.14 888.53,-1651.49 893.28,-1651.1"/>
+</g>
+<!-- succ_c&#45;&gt;e_88_center -->
+<g id="edge322" class="edge">
+<title>succ_c&#45;&gt;e_88_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M720.66,-1674.8C729.74,-1722.61 754.27,-1851.7 758.79,-1875.49"/>
+</g>
+<!-- succ_c&#45;&gt;e_89_center -->
+<g id="edge327" class="edge">
+<title>succ_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.74" d="M718.63,-1638.82C723.69,-1571.27 741.26,-1336.88 743.7,-1304.25"/>
+</g>
+<!-- e_43_center&#45;&gt;q8_c -->
+<g id="edge132" class="edge">
+<title>e_43_center&#45;&gt;q8_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M720.76,-1858.36C733.36,-1845.3 776.5,-1800.68 812.72,-1764.4 816.86,-1760.25 821.32,-1755.84 825.58,-1751.64"/>
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+</g>
+<!-- e_43_center&#45;&gt;succ_c -->
+<g id="edge133" class="edge">
+<title>e_43_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M717.14,-1858.56C717.15,-1838.24 717.22,-1736.05 717.25,-1685.45"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="720.75,-1685.21 717.26,-1675.2 713.75,-1685.2 720.75,-1685.21"/>
+</g>
+<!-- e_44_center&#45;&gt;pyr_c -->
+<g id="edge137" class="edge">
+<title>e_44_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M735.87,-600.28C740.88,-632.97 777,-868.68 789.53,-950.49"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="786.1,-951.19 791.07,-960.55 793.02,-950.13 786.1,-951.19"/>
+</g>
+<!-- e_44_center&#45;&gt;f6p_c -->
+<g id="edge136" class="edge">
+<title>e_44_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M739.14,-597.85C752.53,-602.5 798.42,-618.2 837.12,-628.34 860.61,-634.49 887.62,-640.12 907.3,-643.96"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="906.65,-647.4 917.14,-645.85 907.98,-640.53 906.65,-647.4"/>
+</g>
+<!-- mal__L_c -->
+<g id="node106" class="node">
+<title>mal__L_c</title>
+<ellipse fill="none" stroke="black" cx="977.94" cy="-1337.39" rx="18" ry="18"/>
+<text text-anchor="middle" x="977.94" y="-1333.69" font-family="Times,serif" font-size="14.00">mal__L_c</text>
+</g>
+<!-- mal__L_c&#45;&gt;e_63_center -->
+<g id="edge224" class="edge">
+<title>mal__L_c&#45;&gt;e_63_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M973.32,-1319.85C966.03,-1292.09 952.26,-1239.72 948.53,-1225.54"/>
+</g>
+<!-- mal__L_c&#45;&gt;e_64_center -->
+<g id="edge229" class="edge">
+<title>mal__L_c&#45;&gt;e_64_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M979.24,-1319.2C981.57,-1287 986.68,-1217.85 991.77,-1159.54 993.4,-1140.77 995.67,-1118.32 996.56,-1109.68"/>
+</g>
+<!-- mal__L_c&#45;&gt;e_65_center -->
+<g id="edge234" class="edge">
+<title>mal__L_c&#45;&gt;e_65_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M979.62,-1319.39C981.4,-1301.82 984.59,-1274.36 989.06,-1250.85 1003.5,-1174.8 1030.21,-1083.82 1035.88,-1064.83"/>
+</g>
+<!-- e_45_center&#45;&gt;mal__L_c -->
+<g id="edge140" class="edge">
+<title>e_45_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M806.78,-1466.39C825.68,-1452.14 913.18,-1386.19 955.24,-1354.5"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.74" points="957.6,-1357.1 963.48,-1348.28 953.39,-1351.51 957.6,-1357.1"/>
+</g>
+<!-- e_46_center&#45;&gt;h_c -->
+<g id="edge143" class="edge">
+<title>e_46_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1004.87,-1695.25C997.65,-1670.03 954.43,-1517.94 926.62,-1392.38 922.66,-1374.52 918.92,-1354.32 916.14,-1338.41"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="919.52,-1337.42 914.37,-1328.16 912.62,-1338.61 919.52,-1337.42"/>
+</g>
+<!-- e_46_center&#45;&gt;fum_c -->
+<g id="edge144" class="edge">
+<title>e_46_center&#45;&gt;fum_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1002.17,-1700.53C983.12,-1708.97 896.25,-1747.46 852.21,-1766.98"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="850.72,-1763.81 843,-1771.06 853.56,-1770.21 850.72,-1763.81"/>
+</g>
+<!-- 6pgl_c -->
+<g id="node109" class="node">
+<title>6pgl_c</title>
+<ellipse fill="none" stroke="black" cx="1228.21" cy="-853.67" rx="18" ry="18"/>
+<text text-anchor="middle" x="1228.21" y="-849.97" font-family="Times,serif" font-size="14.00">6pgl_c</text>
+</g>
+<!-- 6pgl_c&#45;&gt;e_75_center -->
+<g id="edge271" class="edge">
+<title>6pgl_c&#45;&gt;e_75_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1218.24,-869.01C1203.41,-891.47 1174.23,-934.32 1145.99,-968.09 1123.44,-995.06 1092.72,-1024.37 1082.41,-1034.04"/>
+</g>
+<!-- e_47_center&#45;&gt;h_c -->
+<g id="edge148" class="edge">
+<title>e_47_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1067.48,-971.03C1062.11,-982.99 1044.57,-1022.11 1030.26,-1054.55 996.19,-1131.78 990.83,-1152.53 954.28,-1228.62 945.05,-1247.83 933.8,-1269.14 925.15,-1285.14"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.71" points="921.84,-1283.9 920.14,-1294.36 927.99,-1287.25 921.84,-1283.9"/>
+</g>
+<!-- e_47_center&#45;&gt;nadph_c -->
+<g id="edge149" class="edge">
+<title>e_47_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1073.03,-969.38C1083.5,-974.76 1112.9,-989.86 1134.63,-1001.01"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.71" points="1133.19,-1004.21 1143.69,-1005.67 1136.39,-997.98 1133.19,-1004.21"/>
+</g>
+<!-- e_47_center&#45;&gt;6pgl_c -->
+<g id="edge147" class="edge">
+<title>e_47_center&#45;&gt;6pgl_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1072.74,-964.79C1090.13,-952.36 1165.77,-898.3 1204.77,-870.43"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.71" points="1207.29,-872.93 1213.39,-864.26 1203.22,-867.23 1207.29,-872.93"/>
+</g>
+<!-- 13dpg_c -->
+<g id="node111" class="node">
+<title>13dpg_c</title>
+<ellipse fill="none" stroke="black" cx="832.63" cy="-717.99" rx="18" ry="18"/>
+<text text-anchor="middle" x="832.63" y="-714.29" font-family="Times,serif" font-size="14.00">13dpg_c</text>
+</g>
+<!-- e_48_center&#45;&gt;nadh_c -->
+<g id="edge154" class="edge">
+<title>e_48_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.51" d="M975.74,-955.83C982.53,-979.45 1021.69,-1115.59 1038.64,-1174.51"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.51" points="1034.89,-1175.72 1041.44,-1184.24 1042.47,-1173.54 1034.89,-1175.72"/>
+</g>
+<!-- e_48_center&#45;&gt;h_c -->
+<g id="edge155" class="edge">
+<title>e_48_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.51" d="M973.51,-955.98C969.78,-967.38 958.4,-1003.15 951.94,-1033.52 932.8,-1123.52 919.78,-1231.92 914.32,-1282.1"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.51" points="910.38,-1281.81 913.24,-1292.18 918.22,-1282.65 910.38,-1281.81"/>
+</g>
+<!-- e_48_center&#45;&gt;13dpg_c -->
+<g id="edge153" class="edge">
+<title>e_48_center&#45;&gt;13dpg_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.51" d="M972.49,-948.62C958.31,-925.23 880.27,-796.54 847.32,-742.21"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.51" points="850.63,-740.06 842.08,-733.56 843.89,-744.15 850.63,-740.06"/>
+</g>
+<!-- e_49_center&#45;&gt;pyr_c -->
+<g id="edge159" class="edge">
+<title>e_49_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.78" d="M681.06,-637.83C683.45,-658.49 696.92,-764.21 731.02,-842.8 747.76,-881.37 768.47,-925.45 781.41,-952.6"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.78" points="778.34,-954.28 785.81,-961.79 784.65,-951.26 778.34,-954.28"/>
+</g>
+<!-- e_49_center&#45;&gt;g6p_c -->
+<g id="edge158" class="edge">
+<title>e_49_center&#45;&gt;g6p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.78" d="M684.32,-635.69C702.22,-642.78 782.36,-674.76 846.58,-704.21 862.83,-711.67 880.8,-720.58 894.93,-727.74"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.78" points="893.54,-730.96 904.04,-732.38 896.72,-724.72 893.54,-730.96"/>
+</g>
+<!-- nh4_c&#45;&gt;e_50_center -->
+<g id="edge162" class="edge">
+<title>nh4_c&#45;&gt;e_50_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.55" d="M1242.83,-933.79C1184.08,-955.79 992.13,-1027.68 962.5,-1038.78"/>
+</g>
+<!-- e_50_center&#45;&gt;h_c -->
+<g id="edge163" class="edge">
+<title>e_50_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.55" d="M957.97,-1044.04C953.47,-1069.78 927.36,-1218.95 916.33,-1282"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.55" points="912.85,-1281.58 914.58,-1292.04 919.75,-1282.79 912.85,-1281.58"/>
+</g>
+<!-- e_50_center&#45;&gt;adp_c -->
+<g id="edge166" class="edge">
+<title>e_50_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.55" d="M954.88,-1039.14C944.45,-1036.17 914.23,-1027.84 888.59,-1023.48 838.54,-1014.98 779.52,-1010.05 745.39,-1007.69"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.55" points="745.44,-1004.18 735.23,-1007.01 744.98,-1011.17 745.44,-1004.18"/>
+</g>
+<!-- e_50_center&#45;&gt;pi_c -->
+<g id="edge164" class="edge">
+<title>e_50_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.55" d="M955.13,-1041.45C936.32,-1048.03 846.69,-1079.41 801.18,-1095.34"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.55" points="799.95,-1092.06 791.67,-1098.67 802.26,-1098.67 799.95,-1092.06"/>
+</g>
+<!-- e_50_center&#45;&gt;gln__L_c -->
+<g id="edge165" class="edge">
+<title>e_50_center&#45;&gt;gln__L_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.55" d="M955.1,-1037.2C945.36,-1028.89 917.55,-1005.16 897.73,-988.25"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.55" points="899.94,-985.53 890.06,-981.7 895.4,-990.86 899.94,-985.53"/>
+</g>
+<!-- e_51_center&#45;&gt;h_c -->
+<g id="edge170" class="edge">
+<title>e_51_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M626.98,-1045.51C637.61,-1059.57 676.13,-1109.64 713.1,-1146.07 772.33,-1204.43 850.23,-1264.62 888.37,-1293.15"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="886.63,-1296.22 896.74,-1299.38 890.81,-1290.6 886.63,-1296.22"/>
+</g>
+<!-- e_51_center&#45;&gt;adp_c -->
+<g id="edge173" class="edge">
+<title>e_51_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M627.64,-1041.08C635.57,-1039.61 655.44,-1035.59 671.21,-1029.58 678.19,-1026.93 685.49,-1023.5 692.15,-1020.08"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="694.19,-1022.96 701.37,-1015.17 690.89,-1016.78 694.19,-1022.96"/>
+</g>
+<!-- e_51_center&#45;&gt;pi_c -->
+<g id="edge171" class="edge">
+<title>e_51_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M627.85,-1043.26C644.25,-1050.13 711,-1078.06 748.56,-1093.78"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="747.29,-1097.04 757.87,-1097.68 750,-1090.59 747.29,-1097.04"/>
+</g>
+<!-- e_51_center&#45;&gt;gln__L_c -->
+<g id="edge172" class="edge">
+<title>e_51_center&#45;&gt;gln__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M627.72,-1041.3C640.2,-1039.83 682.81,-1034.44 717.05,-1025.55 764.87,-1013.13 818.83,-992.92 850.06,-980.59"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="851.37,-983.84 859.36,-976.88 848.78,-977.33 851.37,-983.84"/>
+</g>
+<!-- e_52_center&#45;&gt;h_c -->
+<g id="edge179" class="edge">
+<title>e_52_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.57" d="M1052.46,-1101.88C1045.24,-1112.84 1023.48,-1145.78 1005.17,-1172.94 978.22,-1212.9 946.5,-1259.15 927.73,-1286.44"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.57" points="924.67,-1284.71 921.88,-1294.93 930.43,-1288.68 924.67,-1284.71"/>
+</g>
+<!-- e_52_center&#45;&gt;akg_c -->
+<g id="edge180" class="edge">
+<title>e_52_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.57" d="M1058.66,-1101.19C1071.86,-1112 1117.1,-1149.05 1144.73,-1171.68"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.57" points="1142.73,-1174.57 1152.68,-1178.2 1147.16,-1169.16 1142.73,-1174.57"/>
+</g>
+<!-- e_52_center&#45;&gt;nadph_c -->
+<g id="edge178" class="edge">
+<title>e_52_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.57" d="M1058.92,-1094.94C1071.65,-1084.75 1111.96,-1052.48 1137.66,-1031.91"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.57" points="1140.13,-1034.41 1145.75,-1025.43 1135.76,-1028.95 1140.13,-1034.41"/>
+</g>
+<!-- e_52_center&#45;&gt;nh4_c -->
+<g id="edge177" class="edge">
+<title>e_52_center&#45;&gt;nh4_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.57" d="M1057.79,-1094.44C1068.46,-1080.83 1107.27,-1032.56 1146.2,-1000.1 1174.63,-976.39 1211.28,-954.25 1235.17,-940.78"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.57" points="1236.92,-943.81 1243.96,-935.89 1233.52,-937.69 1236.92,-943.81"/>
+</g>
+<!-- e_53_center&#45;&gt;glu__L_c -->
+<g id="edge184" class="edge">
+<title>e_53_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1025.83,-977.02C1035.89,-984.95 1064.66,-1008.22 1085.57,-1030.63 1103.67,-1050.03 1121.96,-1074.13 1134.57,-1091.62"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1131.96,-1093.99 1140.61,-1100.11 1137.66,-1089.93 1131.96,-1093.99"/>
+</g>
+<!-- e_53_center&#45;&gt;nh4_c -->
+<g id="edge183" class="edge">
+<title>e_53_center&#45;&gt;nh4_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1025.88,-972.39C1039.57,-965.9 1088.92,-943.38 1132.34,-934.55 1165.81,-927.74 1205.17,-926.54 1231.22,-926.66"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1231.47,-930.16 1241.51,-926.78 1231.55,-923.16 1231.47,-930.16"/>
+</g>
+<!-- e_54_center&#45;&gt;glu__L_c -->
+<g id="edge190" class="edge">
+<title>e_54_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1093.66,-1113.59C1099.42,-1113.75 1111.19,-1114.06 1122.57,-1114.36"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1122.63,-1117.87 1132.72,-1114.63 1122.82,-1110.87 1122.63,-1117.87"/>
+</g>
+<!-- e_54_center&#45;&gt;nadp_c -->
+<g id="edge189" class="edge">
+<title>e_54_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1093.96,-1111.62C1105.95,-1105.88 1142.76,-1088.28 1168.1,-1076.16"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1169.67,-1079.29 1177.18,-1071.82 1166.65,-1072.98 1169.67,-1079.29"/>
+</g>
+<!-- e_55_center&#45;&gt;h_c -->
+<g id="edge193" class="edge">
+<title>e_55_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1209.02,-1404.47C1187.29,-1394.02 1075.36,-1341.38 977.98,-1317.79 965.6,-1314.79 951.63,-1312.96 939.7,-1311.83"/>
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+</g>
+<!-- e_55_center&#45;&gt;glu__L_c -->
+<g id="edge194" class="edge">
+<title>e_55_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1212.7,-1402.65C1212.14,-1381.69 1208.27,-1274.19 1186.45,-1189.95 1184.78,-1183.49 1183.53,-1182.13 1180.81,-1176.05 1175.49,-1164.15 1169.19,-1151.17 1163.75,-1140.25"/>
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+</g>
+<!-- 6pgc_c -->
+<g id="node121" class="node">
+<title>6pgc_c</title>
+<ellipse fill="none" stroke="black" cx="1357.1" cy="-922.35" rx="18" ry="18"/>
+<text text-anchor="middle" x="1357.1" y="-918.65" font-family="Times,serif" font-size="14.00">6pgc_c</text>
+</g>
+<!-- 6pgc_c&#45;&gt;e_56_center -->
+<g id="edge196" class="edge">
+<title>6pgc_c&#45;&gt;e_56_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1348.22,-906.39C1335.34,-883.24 1312.24,-841.72 1305.33,-829.31"/>
+</g>
+<!-- xu5p__D_c -->
+<g id="node147" class="node">
+<title>xu5p__D_c</title>
+<ellipse fill="none" stroke="black" cx="1309.8" cy="-319.98" rx="18" ry="18"/>
+<text text-anchor="middle" x="1309.8" y="-316.28" font-family="Times,serif" font-size="14.00">xu5p__D_c</text>
+</g>
+<!-- ru5p__D_c&#45;&gt;xu5p__D_c -->
+<g id="edge311" class="edge">
+<title>ru5p__D_c&#45;&gt;xu5p__D_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.76" d="M1358.64,-524.38C1349.4,-485.68 1327.42,-393.7 1316.38,-347.48"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.76" points="1319.73,-346.47 1314,-337.56 1312.92,-348.1 1319.73,-346.47"/>
+</g>
+<!-- e_56_center&#45;&gt;co2_c -->
+<g id="edge198" class="edge">
+<title>e_56_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1299.76,-828.4C1281.3,-842.25 1196.02,-906.26 1154.73,-937.25"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.71" points="1152.53,-934.53 1146.63,-943.33 1156.73,-940.13 1152.53,-934.53"/>
+</g>
+<!-- e_56_center&#45;&gt;nadph_c -->
+<g id="edge199" class="edge">
+<title>e_56_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1300.6,-829.31C1285.47,-849.19 1211.46,-946.41 1177.31,-991.27"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.71" points="1174.31,-989.43 1171.04,-999.5 1179.88,-993.67 1174.31,-989.43"/>
+</g>
+<!-- e_56_center&#45;&gt;ru5p__D_c -->
+<g id="edge197" class="edge">
+<title>e_56_center&#45;&gt;ru5p__D_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1304.09,-822.13C1309.55,-796.14 1343.24,-635.78 1357.03,-570.14"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.71" points="1360.5,-570.61 1359.14,-560.1 1353.65,-569.17 1360.5,-570.61"/>
+</g>
+<!-- e_58_center&#45;&gt;akg_c -->
+<g id="edge205" class="edge">
+<title>e_58_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M1002.21,-1165.5C1015.25,-1163.07 1059.76,-1155.75 1095.81,-1161.76 1111.55,-1164.38 1128.19,-1170.73 1141.4,-1176.73"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3" points="1140.24,-1180.05 1150.77,-1181.18 1143.24,-1173.73 1140.24,-1180.05"/>
+</g>
+<!-- e_58_center&#45;&gt;co2_c -->
+<g id="edge203" class="edge">
+<title>e_58_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M1000.85,-1162.43C1007.84,-1151.3 1029.01,-1117.96 1048.23,-1091.44 1063.97,-1069.72 1071.03,-1066.56 1085.57,-1044.03 1098.98,-1023.24 1111.74,-998.15 1120.51,-979.77"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3" points="1123.75,-981.11 1124.84,-970.57 1117.42,-978.13 1123.75,-981.11"/>
+</g>
+<!-- e_58_center&#45;&gt;nadph_c -->
+<g id="edge204" class="edge">
+<title>e_58_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M1002.14,-1162.77C1020.21,-1145.75 1100.21,-1070.36 1138.9,-1033.91"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3" points="1141.61,-1036.16 1146.49,-1026.75 1136.81,-1031.06 1141.61,-1036.16"/>
+</g>
+<!-- glx_c -->
+<g id="node125" class="node">
+<title>glx_c</title>
+<ellipse fill="none" stroke="black" cx="518.83" cy="-1516.48" rx="18" ry="18"/>
+<text text-anchor="middle" x="518.83" y="-1512.78" font-family="Times,serif" font-size="14.00">glx_c</text>
+</g>
+<!-- glx_c&#45;&gt;e_61_center -->
+<g id="edge216" class="edge">
+<title>glx_c&#45;&gt;e_61_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M533.35,-1505.72C579.82,-1471.32 723.22,-1365.14 747.52,-1347.15"/>
+</g>
+<!-- e_59_center&#45;&gt;succ_c -->
+<g id="edge208" class="edge">
+<title>e_59_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M543.26,-1615.01C561.86,-1619.5 645.75,-1639.73 689.9,-1650.39"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="689.16,-1653.81 699.7,-1652.75 690.8,-1647 689.16,-1653.81"/>
+</g>
+<!-- e_59_center&#45;&gt;glx_c -->
+<g id="edge207" class="edge">
+<title>e_59_center&#45;&gt;glx_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M538.76,-1610.41C536.48,-1599.67 529.72,-1567.79 524.7,-1544.14"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="528.1,-1543.33 522.6,-1534.27 521.26,-1544.78 528.1,-1543.33"/>
+</g>
+<!-- e_60_center&#45;&gt;nadh_c -->
+<g id="edge211" class="edge">
+<title>e_60_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M999.09,-1253.88C1004.74,-1247.65 1016.64,-1234.54 1027.09,-1223.02"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1029.88,-1225.16 1034.01,-1215.4 1024.7,-1220.45 1029.88,-1225.16"/>
+</g>
+<!-- e_60_center&#45;&gt;h_c -->
+<g id="edge213" class="edge">
+<title>e_60_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M992.14,-1259.81C982.51,-1265.81 955.67,-1282.53 935.56,-1295.07"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="933.52,-1292.21 926.88,-1300.47 937.22,-1298.16 933.52,-1292.21"/>
+</g>
+<!-- e_60_center&#45;&gt;pyr_c -->
+<g id="edge212" class="edge">
+<title>e_60_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M993.21,-1254.02C974.23,-1227.79 854.7,-1062.55 810.34,-1001.23"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="813.06,-999.02 804.36,-992.97 807.39,-1003.12 813.06,-999.02"/>
+</g>
+<!-- e_61_center&#45;&gt;coa_c -->
+<g id="edge218" class="edge">
+<title>e_61_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M753.79,-1340.92C765.4,-1325.65 811,-1265.7 836.47,-1232.22"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="839.51,-1234 842.78,-1223.92 833.94,-1229.76 839.51,-1234"/>
+</g>
+<!-- e_61_center&#45;&gt;h_c -->
+<g id="edge219" class="edge">
+<title>e_61_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M754.69,-1343.76C771.64,-1340.12 843.52,-1324.69 883.79,-1316.04"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="884.73,-1319.42 893.77,-1313.9 883.26,-1312.58 884.73,-1319.42"/>
+</g>
+<!-- e_61_center&#45;&gt;mal__L_c -->
+<g id="edge217" class="edge">
+<title>e_61_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M754.6,-1344.43C776.59,-1343.74 894.66,-1340.02 949.68,-1338.28"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="949.91,-1341.78 959.8,-1337.96 949.69,-1334.78 949.91,-1341.78"/>
+</g>
+<!-- e_62_center&#45;&gt;h_c -->
+<g id="edge223" class="edge">
+<title>e_62_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1116.48,-1554.31C1096.14,-1530.09 975.83,-1386.82 929.55,-1331.71"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="932.14,-1329.35 923.03,-1323.94 926.78,-1333.85 932.14,-1329.35"/>
+</g>
+<!-- e_62_center&#45;&gt;mal__L_c -->
+<g id="edge222" class="edge">
+<title>e_62_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1116.97,-1553.98C1102.32,-1531.17 1026.05,-1412.35 993.11,-1361.04"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="996.02,-1359.08 987.67,-1352.56 990.13,-1362.86 996.02,-1359.08"/>
+</g>
+<!-- e_63_center&#45;&gt;nadh_c -->
+<g id="edge226" class="edge">
+<title>e_63_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M951.33,-1221.15C962.21,-1218.92 994.49,-1212.32 1018.45,-1207.41"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.74" points="1019.35,-1210.8 1028.44,-1205.37 1017.94,-1203.94 1019.35,-1210.8"/>
+</g>
+<!-- e_63_center&#45;&gt;h_c -->
+<g id="edge227" class="edge">
+<title>e_63_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M946.02,-1225.71C941.96,-1235.62 930.75,-1262.96 922.18,-1283.86"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.74" points="918.9,-1282.63 918.34,-1293.21 925.38,-1285.29 918.9,-1282.63"/>
+</g>
+<!-- e_63_center&#45;&gt;oaa_c -->
+<g id="edge228" class="edge">
+<title>e_63_center&#45;&gt;oaa_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M944.9,-1218.3C931.95,-1200.78 875.3,-1124.17 846.61,-1085.38"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.74" points="849.38,-1083.23 840.62,-1077.27 843.75,-1087.39 849.38,-1083.23"/>
+</g>
+<!-- e_64_center&#45;&gt;nadh_c -->
+<g id="edge232" class="edge">
+<title>e_64_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M998.81,-1109.69C1004.4,-1120.48 1021.28,-1153.07 1033.36,-1176.39"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1030.33,-1178.15 1038.04,-1185.42 1036.54,-1174.93 1030.33,-1178.15"/>
+</g>
+<!-- e_64_center&#45;&gt;co2_c -->
+<g id="edge231" class="edge">
+<title>e_64_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M998.94,-1102.37C1003.78,-1093.65 1016.67,-1071.23 1030.26,-1054.55 1055.45,-1023.64 1089.13,-992.03 1110.75,-972.74"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1113.23,-975.22 1118.4,-965.98 1108.59,-969.97 1113.23,-975.22"/>
+</g>
+<!-- e_64_center&#45;&gt;pyr_c -->
+<g id="edge233" class="edge">
+<title>e_64_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M993.1,-1105.05C985.21,-1102.9 966.69,-1097.46 952.36,-1090.12 899.99,-1063.27 845.23,-1021.01 815.75,-996.88"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="817.73,-993.97 807.79,-990.3 813.27,-999.37 817.73,-993.97"/>
+</g>
+<!-- e_65_center&#45;&gt;co2_c -->
+<g id="edge236" class="edge">
+<title>e_65_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1040.13,-1057.69C1051.36,-1045.06 1089.87,-1001.76 1113.38,-975.32"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1116.12,-977.51 1120.15,-967.71 1110.89,-972.86 1116.12,-977.51"/>
+</g>
+<!-- e_65_center&#45;&gt;nadph_c -->
+<g id="edge238" class="edge">
+<title>e_65_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1040.52,-1060.05C1048.57,-1057.31 1068.82,-1050.37 1085.57,-1044.03 1101.61,-1037.96 1119.43,-1030.79 1133.61,-1024.98"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1135.3,-1028.07 1143.22,-1021.03 1132.64,-1021.6 1135.3,-1028.07"/>
+</g>
+<!-- e_65_center&#45;&gt;pyr_c -->
+<g id="edge237" class="edge">
+<title>e_65_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1033.41,-1059.79C1023.02,-1055.54 991.73,-1042.87 965.34,-1033.52 914.83,-1015.64 855.12,-997 821.13,-986.62"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="822.04,-983.23 811.45,-983.67 820,-989.93 822.04,-983.23"/>
+</g>
+<!-- e_66_center&#45;&gt;nad_c -->
+<g id="edge244" class="edge">
+<title>e_66_center&#45;&gt;nad_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M967.24,-1471.83C977.18,-1448.53 1032.41,-1319.38 1079.78,-1215.14 1080.98,-1212.48 1082.26,-1209.71 1083.54,-1206.96"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="1087.54,-1208.72 1087.82,-1197.81 1079.62,-1205.01 1087.54,-1208.72"/>
+</g>
+<!-- e_66_center&#45;&gt;h_e -->
+<g id="edge243" class="edge">
+<title>e_66_center&#45;&gt;h_e</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M961.93,-1478.64C957.13,-1482.64 948.44,-1489.9 940.05,-1496.91"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="937.1,-1493.67 932.23,-1503.43 942.71,-1500.39 937.1,-1493.67"/>
+</g>
+<!-- e_66_center&#45;&gt;q8h2_c -->
+<g id="edge242" class="edge">
+<title>e_66_center&#45;&gt;q8h2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M963.42,-1479.2C958.05,-1487.96 944.03,-1510.68 931.74,-1529.28 889.57,-1593.1 837.7,-1666.9 811.69,-1703.61"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="807.88,-1701.43 805.66,-1712.11 815.01,-1706.49 807.88,-1701.43"/>
+</g>
+<!-- e_67_center&#45;&gt;nadh_c -->
+<g id="edge248" class="edge">
+<title>e_67_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1274.88,-1136.09C1259.78,-1139.98 1199.83,-1155.96 1153.09,-1175.86 1127.42,-1186.79 1122.89,-1195.4 1095.54,-1200.96 1088.96,-1202.29 1081.79,-1202.87 1075.01,-1203.04"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1074.82,-1199.54 1064.81,-1203.01 1074.8,-1206.54 1074.82,-1199.54"/>
+</g>
+<!-- e_67_center&#45;&gt;nadp_c -->
+<g id="edge247" class="edge">
+<title>e_67_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1274.81,-1132.12C1264.71,-1123.65 1235.79,-1099.4 1215.34,-1082.25"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1217.35,-1079.37 1207.44,-1075.63 1212.85,-1084.73 1217.35,-1079.37"/>
+</g>
+<!-- e_70_center&#45;&gt;accoa_c -->
+<g id="edge254" class="edge">
+<title>e_70_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.67" d="M955.39,-1085.31C939.13,-1093.67 872.85,-1127.77 835.78,-1146.84"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.67" points="833.89,-1143.88 826.6,-1151.56 837.09,-1150.1 833.89,-1143.88"/>
+</g>
+<!-- e_70_center&#45;&gt;nadh_c -->
+<g id="edge256" class="edge">
+<title>e_70_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.67" d="M961.77,-1087.09C971.89,-1100.78 1008,-1149.64 1029.66,-1178.95"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.67" points="1026.86,-1181.05 1035.62,-1187.01 1032.49,-1176.89 1026.86,-1181.05"/>
+</g>
+<!-- e_70_center&#45;&gt;co2_c -->
+<g id="edge255" class="edge">
+<title>e_70_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.67" d="M962.68,-1080.72C981.36,-1066.77 1067.65,-1002.35 1109.43,-971.16"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.67" points="1111.71,-973.82 1117.63,-965.04 1107.52,-968.21 1111.71,-973.82"/>
+</g>
+<!-- e_71_center&#45;&gt;h_c -->
+<g id="edge260" class="edge">
+<title>e_71_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.34" d="M839.5,-904.98C845.39,-938.16 891.12,-1195.77 906.43,-1282.06"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.34" points="903.03,-1282.92 908.23,-1292.16 909.92,-1281.7 903.03,-1282.92"/>
+</g>
+<!-- e_71_center&#45;&gt;adp_c -->
+<g id="edge261" class="edge">
+<title>e_71_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.34" d="M835.36,-904.46C821.39,-916.45 769.05,-961.37 738.89,-987.25"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.34" points="736.34,-984.83 731.03,-994 740.89,-990.14 736.34,-984.83"/>
+</g>
+<!-- e_71_center&#45;&gt;fdp_c -->
+<g id="edge259" class="edge">
+<title>e_71_center&#45;&gt;fdp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.34" d="M839.44,-897.71C842.26,-878.67 854.56,-790.52 852.23,-718.11 851.33,-690.12 846.55,-658.46 842.61,-636.43"/>
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+</g>
+<!-- e_72_center&#45;&gt;accoa_c -->
+<g id="edge264" class="edge">
+<title>e_72_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M619.06,-1222.94C639.18,-1216.31 735.75,-1184.49 783.51,-1168.76"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="784.78,-1172.03 793.18,-1165.57 782.59,-1165.38 784.78,-1172.03"/>
+</g>
+<!-- e_72_center&#45;&gt;for_c -->
+<g id="edge265" class="edge">
+<title>e_72_center&#45;&gt;for_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M612.38,-1227.92C593.27,-1252.19 486.75,-1387.41 444.33,-1441.26"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="441.53,-1439.16 438.09,-1449.18 447.03,-1443.49 441.53,-1439.16"/>
+</g>
+<!-- e_74_center&#45;&gt;adp_c -->
+<g id="edge270" class="edge">
+<title>e_74_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.96" d="M665.82,-811.12C671.22,-831.61 697.1,-929.96 709.9,-978.6"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.96" points="706.57,-979.67 712.5,-988.45 713.34,-977.89 706.57,-979.67"/>
+</g>
+<!-- e_74_center&#45;&gt;13dpg_c -->
+<g id="edge269" class="edge">
+<title>e_74_center&#45;&gt;13dpg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.96" d="M668.33,-805.47C686.01,-796.05 766.23,-753.34 807.67,-731.28"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.96" points="809.42,-734.31 816.6,-726.52 806.13,-728.13 809.42,-734.31"/>
+</g>
+<!-- e_75_center&#45;&gt;h_c -->
+<g id="edge273" class="edge">
+<title>e_75_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1076.75,-1040.98C1071.72,-1049.68 1058.7,-1072.31 1048.23,-1091.44 1028.57,-1127.38 1026.33,-1137.86 1005.17,-1172.94 980.27,-1214.21 947.93,-1260.05 928.47,-1286.91"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.71" points="925.45,-1285.11 922.39,-1295.26 931.11,-1289.23 925.45,-1285.11"/>
+</g>
+<!-- e_75_center&#45;&gt;6pgc_c -->
+<g id="edge274" class="edge">
+<title>e_75_center&#45;&gt;6pgc_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1082.44,-1035.15C1092.35,-1029.17 1121.14,-1012.08 1146.2,-1000.1 1210,-969.58 1289.16,-943.31 1329.96,-930.57"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.71" points="1331.19,-933.85 1339.71,-927.55 1329.12,-927.16 1331.19,-933.85"/>
+</g>
+<!-- e_77_center&#45;&gt;h_c -->
+<g id="edge279" class="edge">
+<title>e_77_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.04" d="M684.66,-1441.52C707.55,-1428.25 833.07,-1355.52 886.89,-1324.33"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.04" points="888.87,-1327.22 895.77,-1319.18 885.36,-1321.17 888.87,-1327.22"/>
+</g>
+<!-- e_77_center&#45;&gt;pi_c -->
+<g id="edge278" class="edge">
+<title>e_77_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.04" d="M682.09,-1439.81C690.45,-1409.51 746.4,-1206.71 766.98,-1132.12"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.04" points="770.46,-1132.65 769.75,-1122.08 763.71,-1130.79 770.46,-1132.65"/>
+</g>
+<!-- e_78_center&#45;&gt;h_c -->
+<g id="edge284" class="edge">
+<title>e_78_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.66" d="M882.26,-1033.72C884.96,-1059.32 901.59,-1216.97 908.45,-1282.06"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.66" points="904.98,-1282.45 909.51,-1292.03 911.94,-1281.71 904.98,-1282.45"/>
+</g>
+<!-- e_78_center&#45;&gt;pi_c -->
+<g id="edge283" class="edge">
+<title>e_78_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.66" d="M879.77,-1033.84C874.62,-1042.44 860.62,-1064.14 843.61,-1076.65 831.15,-1085.81 815.27,-1092.52 801.88,-1097.07"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.66" points="800.69,-1093.78 792.22,-1100.14 802.81,-1100.45 800.69,-1093.78"/>
+</g>
+<!-- e_78_center&#45;&gt;oaa_c -->
+<g id="edge285" class="edge">
+<title>e_78_center&#45;&gt;oaa_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.66" d="M878.15,-1032.52C872.99,-1035.74 863.27,-1041.82 853.89,-1047.67"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.66" points="851.79,-1044.86 845.16,-1053.13 855.5,-1050.8 851.79,-1044.86"/>
+</g>
+<!-- e_79_center&#45;&gt;adp_c -->
+<g id="edge290" class="edge">
+<title>e_79_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M868.93,-895.04C852,-907.41 778.44,-961.14 740.28,-989.02"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="737.84,-986.47 731.83,-995.19 741.97,-992.12 737.84,-986.47"/>
+</g>
+<!-- e_79_center&#45;&gt;co2_c -->
+<g id="edge288" class="edge">
+<title>e_79_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M876.14,-893.32C900.8,-899.18 1043.22,-933.01 1104.35,-947.53"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1103.9,-951.02 1114.44,-949.93 1105.52,-944.21 1103.9,-951.02"/>
+</g>
+<!-- e_79_center&#45;&gt;pep_c -->
+<g id="edge289" class="edge">
+<title>e_79_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M868.79,-890.62C854.58,-883.56 802.49,-857.65 770.58,-841.78"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="771.9,-838.53 761.39,-837.21 768.79,-844.8 771.9,-838.53"/>
+</g>
+<!-- e_80_center&#45;&gt;h_c -->
+<g id="edge296" class="edge">
+<title>e_80_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M667.63,-1026.51C691.04,-1053.74 839.59,-1226.56 892.63,-1288.26"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="890.28,-1290.9 899.45,-1296.2 895.59,-1286.34 890.28,-1290.9"/>
+</g>
+<!-- e_80_center&#45;&gt;amp_c -->
+<g id="edge294" class="edge">
+<title>e_80_center&#45;&gt;amp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M660.77,-1020.33C636.84,-1003.98 504.47,-913.55 449.93,-876.28"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="451.81,-873.33 441.58,-870.58 447.86,-879.11 451.81,-873.33"/>
+</g>
+<!-- e_80_center&#45;&gt;pi_c -->
+<g id="edge297" class="edge">
+<title>e_80_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M667.94,-1026.53C675.06,-1034 692.15,-1051.38 708.37,-1063.76 721.5,-1073.78 737.19,-1083.56 750,-1091.04"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="748.32,-1094.12 758.74,-1096.06 751.81,-1088.05 748.32,-1094.12"/>
+</g>
+<!-- e_80_center&#45;&gt;pep_c -->
+<g id="edge295" class="edge">
+<title>e_80_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M666.05,-1019.18C674.39,-999.1 714.56,-902.33 734.17,-855.1"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="737.42,-856.39 738.02,-845.82 730.96,-853.71 737.42,-856.39"/>
+</g>
+<!-- e_81_center&#45;&gt;coa_c -->
+<g id="edge300" class="edge">
+<title>e_81_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M595.5,-1131.02C620.5,-1138.59 765.38,-1182.46 826.61,-1201.01"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="825.77,-1204.41 836.36,-1203.96 827.8,-1197.71 825.77,-1204.41"/>
+</g>
+<!-- e_81_center&#45;&gt;actp_c -->
+<g id="edge301" class="edge">
+<title>e_81_center&#45;&gt;actp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M588.04,-1129.24C562.69,-1124.82 415.76,-1099.2 353.66,-1088.37"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="354.23,-1084.92 343.77,-1086.65 353.02,-1091.81 354.23,-1084.92"/>
+</g>
+<!-- e_82_center&#45;&gt;atp_c -->
+<g id="edge305" class="edge">
+<title>e_82_center&#45;&gt;atp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.12" d="M773.8,-1042.84C768.87,-1043.53 759.6,-1044.81 750.27,-1046.11"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.12" points="749.74,-1042.65 740.32,-1047.49 750.7,-1049.58 749.74,-1042.65"/>
+</g>
+<!-- e_82_center&#45;&gt;pyr_c -->
+<g id="edge306" class="edge">
+<title>e_82_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.12" d="M778.39,-1038.53C780.04,-1032.08 783.53,-1018.47 786.77,-1005.82"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.12" points="790.18,-1006.6 789.28,-996.04 783.4,-1004.86 790.18,-1006.6"/>
+</g>
+<!-- e_83_center&#45;&gt;h_c -->
+<g id="edge310" class="edge">
+<title>e_83_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M647.93,-1319.93C673.31,-1318.98 819.84,-1313.53 882.74,-1311.18"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="883.26,-1314.67 893.12,-1310.8 883,-1307.67 883.26,-1314.67"/>
+</g>
+<!-- e_83_center&#45;&gt;pyr_c -->
+<g id="edge309" class="edge">
+<title>e_83_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M645.05,-1316.35C650.03,-1295.8 675.64,-1194.37 713.12,-1118.36 733.74,-1076.54 761.6,-1030.01 778.6,-1002.52"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="781.61,-1004.3 783.92,-993.96 775.67,-1000.6 781.61,-1004.3"/>
+</g>
+<!-- xu5p__D_c&#45;&gt;e_92_center -->
+<g id="edge342" class="edge">
+<title>xu5p__D_c&#45;&gt;e_92_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.87" d="M1293.37,-327.64C1264.17,-341.26 1204.89,-368.92 1189.66,-376.02"/>
+</g>
+<!-- xu5p__D_c&#45;&gt;e_93_center -->
+<g id="edge346" class="edge">
+<title>xu5p__D_c&#45;&gt;e_93_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.51" d="M1294.8,-330.05C1254.9,-356.85 1147.74,-428.83 1126.38,-443.17"/>
+</g>
+<!-- e_86_center&#45;&gt;h_c -->
+<g id="edge316" class="edge">
+<title>e_86_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M866.7,-1642.03C870.72,-1612.17 897.55,-1413.02 907.61,-1338.33"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="911.1,-1338.63 908.97,-1328.25 904.17,-1337.7 911.1,-1338.63"/>
+</g>
+<!-- e_86_center&#45;&gt;succ_c -->
+<g id="edge315" class="edge">
+<title>e_86_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M862.51,-1646.08C846.65,-1647.27 783.28,-1652.03 745.68,-1654.85"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="745.08,-1651.39 735.38,-1655.63 745.61,-1658.37 745.08,-1651.39"/>
+</g>
+<!-- e_87_center&#45;&gt;h_c -->
+<g id="edge320" class="edge">
+<title>e_87_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M897,-1647C896.86,-1631.02 896.47,-1567.41 898.38,-1515.18 900.7,-1451.96 906.06,-1377.93 909.14,-1338.4"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="912.64,-1338.45 909.94,-1328.2 905.66,-1337.9 912.64,-1338.45"/>
+</g>
+<!-- e_87_center&#45;&gt;succ_e -->
+<g id="edge319" class="edge">
+<title>e_87_center&#45;&gt;succ_e</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M896.83,-1654.37C895.34,-1680.37 886.13,-1840.44 882.34,-1906.53"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="878.83,-1906.46 881.75,-1916.65 885.82,-1906.87 878.83,-1906.46"/>
+</g>
+<!-- e_88_center&#45;&gt;q8h2_c -->
+<g id="edge323" class="edge">
+<title>e_88_center&#45;&gt;q8h2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M760.39,-1875.51C764.23,-1859.09 779.73,-1792.83 788.69,-1754.54"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.74" points="792.15,-1755.08 791.02,-1744.55 785.34,-1753.49 792.15,-1755.08"/>
+</g>
+<!-- e_88_center&#45;&gt;fum_c -->
+<g id="edge324" class="edge">
+<title>e_88_center&#45;&gt;fum_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M762.05,-1875.45C769.92,-1863.59 794.33,-1826.79 810.74,-1802.07"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.74" points="813.76,-1803.84 816.37,-1793.58 807.93,-1799.97 813.76,-1803.84"/>
+</g>
+<!-- e_89_center&#45;&gt;adp_c -->
+<g id="edge330" class="edge">
+<title>e_89_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.74" d="M743.14,-1296.95C738.09,-1275.89 712.03,-1166.42 707.37,-1132.21 702.42,-1095.89 697.96,-1086.21 702.72,-1049.86 703.47,-1044.09 704.95,-1038.07 706.69,-1032.4"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.74" points="710.08,-1033.3 709.98,-1022.7 703.45,-1031.04 710.08,-1033.3"/>
+</g>
+<!-- e_89_center&#45;&gt;succoa_c -->
+<g id="edge329" class="edge">
+<title>e_89_center&#45;&gt;succoa_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.74" d="M747.49,-1302.06C767.81,-1311.3 871.11,-1358.27 920.22,-1380.6"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.74" points="919,-1383.89 929.55,-1384.85 921.9,-1377.52 919,-1383.89"/>
+</g>
+<!-- e_89_center&#45;&gt;pi_c -->
+<g id="edge328" class="edge">
+<title>e_89_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.74" d="M744.57,-1296.73C747.7,-1276.68 762.65,-1180.92 770.18,-1132.63"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.74" points="773.68,-1132.96 771.76,-1122.54 766.76,-1131.88 773.68,-1132.96"/>
+</g>
+<!-- s7p_c -->
+<g id="node152" class="node">
+<title>s7p_c</title>
+<ellipse fill="none" stroke="black" cx="1172.99" cy="-195.1" rx="18" ry="18"/>
+<text text-anchor="middle" x="1172.99" y="-191.4" font-family="Times,serif" font-size="14.00">s7p_c</text>
+</g>
+<!-- s7p_c&#45;&gt;e_90_center -->
+<g id="edge331" class="edge">
+<title>s7p_c&#45;&gt;e_90_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.87" d="M1164.48,-211.18C1140.95,-255.61 1076.03,-378.24 1064.06,-400.84"/>
+</g>
+<!-- e_90_center&#45;&gt;e4p_c -->
+<g id="edge334" class="edge">
+<title>e_90_center&#45;&gt;e4p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.87" d="M1062.3,-408.04C1063.17,-428.66 1067.53,-532.7 1069.66,-583.55"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="0.87" points="1066.17,-583.7 1070.08,-593.55 1073.16,-583.41 1066.17,-583.7"/>
+</g>
+<!-- e_90_center&#45;&gt;f6p_c -->
+<g id="edge333" class="edge">
+<title>e_90_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.87" d="M1060.15,-408.29C1047.45,-432.71 977.57,-567.08 948.07,-623.82"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="0.87" points="944.88,-622.36 943.37,-632.85 951.09,-625.59 944.88,-622.36"/>
+</g>
+<!-- e_91_center&#45;&gt;nad_c -->
+<g id="edge340" class="edge">
+<title>e_91_center&#45;&gt;nad_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1115.38,-1268.54C1113.09,-1258.41 1106.82,-1230.64 1101.96,-1209.14"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1105.33,-1208.17 1099.71,-1199.19 1098.5,-1209.72 1105.33,-1208.17"/>
+</g>
+<!-- e_91_center&#45;&gt;h_c -->
+<g id="edge339" class="edge">
+<title>e_91_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1112.71,-1273.1C1092.33,-1276.85 989.44,-1295.77 939.16,-1305.01"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="938.48,-1301.58 929.27,-1306.83 939.74,-1308.46 938.48,-1301.58"/>
+</g>
+<!-- e_91_center&#45;&gt;nadph_c -->
+<g id="edge338" class="edge">
+<title>e_91_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1116.38,-1268.52C1116.96,-1250.67 1119.98,-1175.49 1131.34,-1115.06 1136.13,-1089.58 1144.44,-1061.23 1150.88,-1041.07"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1154.28,-1041.92 1154.04,-1031.33 1147.62,-1039.75 1154.28,-1041.92"/>
+</g>
+<!-- e_92_center&#45;&gt;g3p_c -->
+<g id="edge344" class="edge">
+<title>e_92_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.87" d="M1183.26,-381.5C1175.15,-392.54 1150.67,-425.67 1129.35,-452.38 1098.8,-490.64 1061.88,-534.06 1040.11,-559.39"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="0.87" points="1037.21,-557.39 1033.34,-567.25 1042.52,-561.96 1037.21,-557.39"/>
+</g>
+<!-- e_92_center&#45;&gt;s7p_c -->
+<g id="edge343" class="edge">
+<title>e_92_center&#45;&gt;s7p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.87" d="M1185.76,-373.9C1184.39,-354.79 1178.24,-268.59 1175,-223.23"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="0.87" points="1178.48,-222.88 1174.28,-213.16 1171.5,-223.38 1178.48,-222.88"/>
+</g>
+<!-- e_93_center&#45;&gt;g3p_c -->
+<g id="edge348" class="edge">
+<title>e_93_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.51" d="M1119.94,-449.3C1108.52,-464.57 1063.67,-524.52 1038.62,-558.01"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="0.51" points="1035.61,-556.2 1032.42,-566.31 1041.21,-560.4 1035.61,-556.2"/>
+</g>
+<!-- e_93_center&#45;&gt;f6p_c -->
+<g id="edge347" class="edge">
+<title>e_93_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.51" d="M1119.03,-449.41C1104.73,-464.16 1050.84,-519.93 1007.72,-566.98 989.02,-587.38 968.11,-611.07 953.51,-627.74"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="0.51" points="950.83,-625.49 946.89,-635.32 956.11,-630.1 950.83,-625.49"/>
+</g>
+</g>
+</svg>
\ No newline at end of file
diff --git a/jupyter_execute/guide/interoperability/cvxpy.ipynb b/jupyter_execute/guide/interoperability/cvxpy.ipynb
index 956f2d00..d1b03568 100644
--- a/jupyter_execute/guide/interoperability/cvxpy.ipynb
+++ b/jupyter_execute/guide/interoperability/cvxpy.ipynb
@@ -70,25 +70,25 @@
       "                                     CVXPY                                     \n",
       "                                     v1.4.3                                    \n",
       "===============================================================================\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Your problem has 5 variables, 2 constraints, and 0 parameters.\n",
-      "(CVXPY) Apr 25 10:40:00 AM: It is compliant with the following grammars: DCP, DQCP\n",
-      "(CVXPY) Apr 25 10:40:00 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n",
-      "(CVXPY) Apr 25 10:40:00 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Your problem is compiled with the CPP canonicalization backend.\n",
+      "(CVXPY) Apr 25 10:46:24 AM: Your problem has 5 variables, 2 constraints, and 0 parameters.\n",
+      "(CVXPY) Apr 25 10:46:24 AM: It is compliant with the following grammars: DCP, DQCP\n",
+      "(CVXPY) Apr 25 10:46:24 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n",
+      "(CVXPY) Apr 25 10:46:24 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n",
+      "(CVXPY) Apr 25 10:46:24 AM: Your problem is compiled with the CPP canonicalization backend.\n",
       "-------------------------------------------------------------------------------\n",
       "                                  Compilation                                  \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Compiling problem (target solver=OSQP).\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Reduction chain: CvxAttr2Constr -> Qp2SymbolicQp -> QpMatrixStuffing -> OSQP\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Applying reduction CvxAttr2Constr\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Applying reduction Qp2SymbolicQp\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Applying reduction QpMatrixStuffing\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Applying reduction OSQP\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Finished problem compilation (took 9.753e-03 seconds).\n",
+      "(CVXPY) Apr 25 10:46:24 AM: Compiling problem (target solver=OSQP).\n",
+      "(CVXPY) Apr 25 10:46:24 AM: Reduction chain: CvxAttr2Constr -> Qp2SymbolicQp -> QpMatrixStuffing -> OSQP\n",
+      "(CVXPY) Apr 25 10:46:24 AM: Applying reduction CvxAttr2Constr\n",
+      "(CVXPY) Apr 25 10:46:24 AM: Applying reduction Qp2SymbolicQp\n",
+      "(CVXPY) Apr 25 10:46:24 AM: Applying reduction QpMatrixStuffing\n",
+      "(CVXPY) Apr 25 10:46:24 AM: Applying reduction OSQP\n",
+      "(CVXPY) Apr 25 10:46:24 AM: Finished problem compilation (took 9.047e-03 seconds).\n",
       "-------------------------------------------------------------------------------\n",
       "                                Numerical solver                               \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Invoking solver OSQP  to obtain a solution.\n",
+      "(CVXPY) Apr 25 10:46:24 AM: Invoking solver OSQP  to obtain a solution.\n",
       "-----------------------------------------------------------------\n",
       "           OSQP v0.6.3  -  Operator Splitting QP Solver\n",
       "              (c) Bartolomeo Stellato,  Goran Banjac\n",
@@ -106,52 +106,52 @@
       "          warm start: on, polish: on, time_limit: off\n",
       "\n",
       "iter   objective    pri res    dua res    rho        time\n",
-      "   1  -5.2220e+00   3.68e+00   1.70e+02   1.00e-01   4.35e-05s\n",
-      " 150   6.9994e-01   1.96e-05   7.82e-06   4.77e+00   9.17e-05s\n",
-      "plsh   7.0000e-01   1.95e-30   0.00e+00   --------   1.20e-04s\n",
+      "   1  -5.2220e+00   3.68e+00   1.70e+02   1.00e-01   4.43e-05s\n",
+      " 150   6.9994e-01   1.96e-05   7.82e-06   4.77e+00   9.01e-05s\n",
+      "plsh   7.0000e-01   1.95e-30   0.00e+00   --------   1.23e-04s\n",
       "\n",
       "status:               solved\n",
       "solution polish:      successful\n",
       "number of iterations: 150\n",
       "optimal objective:    0.7000\n",
-      "run time:             1.20e-04s\n",
+      "run time:             1.23e-04s\n",
       "optimal rho estimate: 9.81e+00\n",
       "\n",
       "-------------------------------------------------------------------------------\n",
       "                                    Summary                                    \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Problem status: optimal\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Optimal value: -3.000e-01\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Compilation took 9.753e-03 seconds\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Solver (including time spent in interface) took 2.524e-03 seconds\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Problem status: optimal\n",
+      "(CVXPY) Apr 25 10:46:24 AM: Optimal value: -3.000e-01\n",
+      "(CVXPY) Apr 25 10:46:24 AM: Compilation took 9.047e-03 seconds\n",
+      "(CVXPY) Apr 25 10:46:24 AM: Solver (including time spent in interface) took 1.582e-03 seconds\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: It is compliant with the following grammars: DCP, DQCP\n"
+      "(CVXPY) Apr 25 10:46:24 AM: It is compliant with the following grammars: DCP, DQCP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
+      "(CVXPY) Apr 25 10:46:24 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:46:24 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: Your problem is compiled with the CPP canonicalization backend.\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Your problem is compiled with the CPP canonicalization backend.\n"
      ]
     },
     {
@@ -161,49 +161,49 @@
       "-------------------------------------------------------------------------------\n",
       "                                  Compilation                                  \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Compiling problem (target solver=OSQP).\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Compiling problem (target solver=OSQP).\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: Reduction chain: CvxAttr2Constr -> Qp2SymbolicQp -> QpMatrixStuffing -> OSQP\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Reduction chain: CvxAttr2Constr -> Qp2SymbolicQp -> QpMatrixStuffing -> OSQP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: Applying reduction CvxAttr2Constr\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Applying reduction CvxAttr2Constr\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: Applying reduction Qp2SymbolicQp\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Applying reduction Qp2SymbolicQp\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: Applying reduction QpMatrixStuffing\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Applying reduction QpMatrixStuffing\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: Applying reduction OSQP\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Applying reduction OSQP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: Finished problem compilation (took 9.753e-03 seconds).\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Finished problem compilation (took 9.047e-03 seconds).\n"
      ]
     },
     {
@@ -213,7 +213,7 @@
       "-------------------------------------------------------------------------------\n",
       "                                Numerical solver                               \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Invoking solver OSQP  to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Invoking solver OSQP  to obtain a solution.\n"
      ]
     },
     {
@@ -237,42 +237,42 @@
       "          warm start: on, polish: on, time_limit: off\n",
       "\n",
       "iter   objective    pri res    dua res    rho        time\n",
-      "   1  -5.2220e+00   3.68e+00   1.70e+02   1.00e-01   4.35e-05s\n",
-      " 150   6.9994e-01   1.96e-05   7.82e-06   4.77e+00   9.17e-05s\n",
-      "plsh   7.0000e-01   1.95e-30   0.00e+00   --------   1.20e-04s\n",
+      "   1  -5.2220e+00   3.68e+00   1.70e+02   1.00e-01   4.43e-05s\n",
+      " 150   6.9994e-01   1.96e-05   7.82e-06   4.77e+00   9.01e-05s\n",
+      "plsh   7.0000e-01   1.95e-30   0.00e+00   --------   1.23e-04s\n",
       "\n",
       "status:               solved\n",
       "solution polish:      successful\n",
       "number of iterations: 150\n",
       "optimal objective:    0.7000\n",
-      "run time:             1.20e-04s\n",
+      "run time:             1.23e-04s\n",
       "optimal rho estimate: 9.81e+00\n",
       "\n",
       "-------------------------------------------------------------------------------\n",
       "                                    Summary                                    \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:00 AM: Problem status: optimal\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Problem status: optimal\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: Optimal value: -3.000e-01\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Optimal value: -3.000e-01\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: Compilation took 9.753e-03 seconds\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Compilation took 9.047e-03 seconds\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:00 AM: Solver (including time spent in interface) took 2.524e-03 seconds\n"
+      "(CVXPY) Apr 25 10:46:24 AM: Solver (including time spent in interface) took 1.582e-03 seconds\n"
      ]
     }
    ],
diff --git a/jupyter_execute/guide/interoperability/networkx.ipynb b/jupyter_execute/guide/interoperability/networkx.ipynb
index f0b8612f..f5bce1b1 100644
--- a/jupyter_execute/guide/interoperability/networkx.ipynb
+++ b/jupyter_execute/guide/interoperability/networkx.ipynb
@@ -230,7 +230,7 @@
        "</svg>\n"
       ],
       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7f85e5fe5550>"
+       "<graphviz.graphs.Digraph at 0x7f91d8b83b10>"
       ]
      },
      "execution_count": 5,
diff --git a/jupyter_execute/guide/interoperability/picos.ipynb b/jupyter_execute/guide/interoperability/picos.ipynb
index 2e6cd2c3..26a22e22 100644
--- a/jupyter_execute/guide/interoperability/picos.ipynb
+++ b/jupyter_execute/guide/interoperability/picos.ipynb
@@ -102,7 +102,7 @@
       "Solver claims optimal solution for feasible problem.\n",
       "Applying the solution.\n",
       "Applied solution is primal feasible.\n",
-      "Search 1.4e-02s, solve 1.9e-02s, overhead 31%.\n",
+      "Search 1.4e-02s, solve 1.9e-02s, overhead 34%.\n",
       "=============[ PICOS ]=============\n"
      ]
     },
@@ -147,7 +147,7 @@
       "Solver claims optimal solution for feasible problem.\n",
       "Applying the solution.\n",
       "Applied solution is primal feasible.\n",
-      "Search 1.4e-02s, solve 1.9e-02s, overhead 31%.\n",
+      "Search 1.4e-02s, solve 1.9e-02s, overhead 34%.\n",
       "=============[ PICOS ]=============\n"
      ]
     }
diff --git a/jupyter_execute/guide/intro/acyclic-flows.ipynb b/jupyter_execute/guide/intro/acyclic-flows.ipynb
index 4a474269..3df6fb43 100644
--- a/jupyter_execute/guide/intro/acyclic-flows.ipynb
+++ b/jupyter_execute/guide/intro/acyclic-flows.ipynb
@@ -204,7 +204,7 @@
        "</svg>\n"
       ],
       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7f4fcef28310>"
+       "<graphviz.graphs.Digraph at 0x7f432231e3d0>"
       ]
      },
      "execution_count": 2,
@@ -405,7 +405,7 @@
        "</svg>\n"
       ],
       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7f4fcf3b8150>"
+       "<graphviz.graphs.Digraph at 0x7f43227c1c90>"
       ]
      },
      "execution_count": 3,
@@ -592,7 +592,7 @@
        "</svg>\n"
       ],
       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7f4fcef742d0>"
+       "<graphviz.graphs.Digraph at 0x7f432236e390>"
       ]
      },
      "execution_count": 6,
@@ -864,7 +864,7 @@
        "</svg>\n"
       ],
       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7f5010bcb350>"
+       "<graphviz.graphs.Digraph at 0x7f4322352b50>"
       ]
      },
      "execution_count": 8,
@@ -1043,7 +1043,7 @@
        "</svg>\n"
       ],
       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7f4fcef662d0>"
+       "<graphviz.graphs.Digraph at 0x7f43226d8e50>"
       ]
      },
      "execution_count": 11,
diff --git a/jupyter_execute/guide/intro/constrained-optimization.ipynb b/jupyter_execute/guide/intro/constrained-optimization.ipynb
index 62f4bb22..77511c89 100644
--- a/jupyter_execute/guide/intro/constrained-optimization.ipynb
+++ b/jupyter_execute/guide/intro/constrained-optimization.ipynb
@@ -93,7 +93,7 @@
     {
      "data": {
       "text/plain": [
-       "<corneto.backend._cvxpy_backend.CvxpyBackend at 0x7fcc1ca007d0>"
+       "<corneto.backend._cvxpy_backend.CvxpyBackend at 0x7f086c7f8e50>"
       ]
      },
      "execution_count": 2,
@@ -147,7 +147,7 @@
     {
      "data": {
       "text/plain": [
-       "<corneto.backend._base.ProblemDef at 0x7fcbeded6210>"
+       "<corneto.backend._base.ProblemDef at 0x7f087c7beed0>"
       ]
      },
      "execution_count": 4,
@@ -254,29 +254,31 @@
       "                                     CVXPY                                     \n",
       "                                     v1.4.3                                    \n",
       "===============================================================================\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Your problem has 50 variables, 1 constraints, and 0 parameters.\n",
-      "(CVXPY) Apr 25 10:40:09 AM: It is compliant with the following grammars: DCP, DQCP\n",
-      "(CVXPY) Apr 25 10:40:09 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n",
-      "(CVXPY) Apr 25 10:40:09 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Your problem is compiled with the CPP canonicalization backend.\n",
+      "(CVXPY) Apr 25 10:46:32 AM: Your problem has 50 variables, 1 constraints, and 0 parameters.\n",
+      "(CVXPY) Apr 25 10:46:32 AM: It is compliant with the following grammars: DCP, DQCP\n",
+      "(CVXPY) Apr 25 10:46:32 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n",
+      "(CVXPY) Apr 25 10:46:32 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n",
+      "(CVXPY) Apr 25 10:46:32 AM: Your problem is compiled with the CPP canonicalization backend.\n",
       "-------------------------------------------------------------------------------\n",
       "                                  Compilation                                  \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Compiling problem (target solver=SCIP).\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Reduction chain: FlipObjective -> Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIP\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Applying reduction FlipObjective\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Applying reduction Dcp2Cone\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Applying reduction CvxAttr2Constr\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Applying reduction ConeMatrixStuffing\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Applying reduction SCIP\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Finished problem compilation (took 8.441e-03 seconds).\n",
+      "(CVXPY) Apr 25 10:46:32 AM: Compiling problem (target solver=SCIP).\n",
+      "(CVXPY) Apr 25 10:46:32 AM: Reduction chain: FlipObjective -> Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIP\n",
+      "(CVXPY) Apr 25 10:46:32 AM: Applying reduction FlipObjective\n",
+      "(CVXPY) Apr 25 10:46:32 AM: Applying reduction Dcp2Cone\n",
+      "(CVXPY) Apr 25 10:46:32 AM: Applying reduction CvxAttr2Constr\n",
+      "(CVXPY) Apr 25 10:46:32 AM: Applying reduction ConeMatrixStuffing\n",
+      "(CVXPY) Apr 25 10:46:32 AM: Applying reduction SCIP\n",
+      "(CVXPY) Apr 25 10:46:32 AM: Finished problem compilation (took 8.368e-03 seconds).\n",
       "-------------------------------------------------------------------------------\n",
       "                                Numerical solver                               \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Invoking solver SCIP  to obtain a solution.\n",
+      "(CVXPY) Apr 25 10:46:32 AM: Invoking solver SCIP  to obtain a solution.\n",
       "-------------------------------------------------------------------------------\n",
       "                                    Summary                                    \n",
-      "-------------------------------------------------------------------------------feasible solution found by trivial heuristic after 0.0 seconds, objective value -6.000000e+02\n",
+      "-------------------------------------------------------------------------------\n",
+      "(CVXPY) Apr 25 10:46:32 AM: Problem status: optimal\n",
+      "feasible solution found by trivial heuristic after 0.0 seconds, objective value -6.000000e+02\n",
       "presolving:\n",
       "(round 1, fast)       4 del vars, 0 del conss, 0 add conss, 0 chg bounds, 0 chg sides, 0 chg coeffs, 0 upgd conss, 0 impls, 0 clqs\n",
       "(round 2, exhaustive) 4 del vars, 0 del conss, 0 add conss, 0 chg bounds, 0 chg sides, 0 chg coeffs, 1 upgd conss, 0 impls, 0 clqs\n",
@@ -293,39 +295,37 @@
       "Primal Bound       : -7.53400000000000e+03 (3 solutions)\n",
       "Dual Bound         : -7.53400000000000e+03\n",
       "Gap                : 0.00 %\n",
-      "\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Problem status: optimal\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Optimal value: 7.534e+03\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Compilation took 8.441e-03 seconds\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Solver (including time spent in interface) took 3.624e-03 seconds\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Optimal value: 7.534e+03\n",
+      "(CVXPY) Apr 25 10:46:32 AM: Compilation took 8.368e-03 seconds\n",
+      "(CVXPY) Apr 25 10:46:32 AM: Solver (including time spent in interface) took 3.592e-03 seconds\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: It is compliant with the following grammars: DCP, DQCP\n"
+      "(CVXPY) Apr 25 10:46:32 AM: It is compliant with the following grammars: DCP, DQCP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
+      "(CVXPY) Apr 25 10:46:32 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:46:32 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Your problem is compiled with the CPP canonicalization backend.\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Your problem is compiled with the CPP canonicalization backend.\n"
      ]
     },
     {
@@ -335,56 +335,56 @@
       "-------------------------------------------------------------------------------\n",
       "                                  Compilation                                  \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Compiling problem (target solver=SCIP).\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Compiling problem (target solver=SCIP).\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Reduction chain: FlipObjective -> Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIP\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Reduction chain: FlipObjective -> Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Applying reduction FlipObjective\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Applying reduction FlipObjective\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Applying reduction Dcp2Cone\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Applying reduction Dcp2Cone\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Applying reduction CvxAttr2Constr\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Applying reduction CvxAttr2Constr\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Applying reduction ConeMatrixStuffing\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Applying reduction ConeMatrixStuffing\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Applying reduction SCIP\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Applying reduction SCIP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Finished problem compilation (took 8.441e-03 seconds).\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Finished problem compilation (took 8.368e-03 seconds).\n"
      ]
     },
     {
@@ -394,7 +394,7 @@
       "-------------------------------------------------------------------------------\n",
       "                                Numerical solver                               \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Invoking solver SCIP  to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Invoking solver SCIP  to obtain a solution.\n"
      ]
     },
     {
@@ -403,7 +403,9 @@
      "text": [
       "-------------------------------------------------------------------------------\n",
       "                                    Summary                                    \n",
-      "-------------------------------------------------------------------------------feasible solution found by trivial heuristic after 0.0 seconds, objective value -6.000000e+02\n",
+      "-------------------------------------------------------------------------------\n",
+      "(CVXPY) Apr 25 10:46:32 AM: Problem status: optimal\n",
+      "feasible solution found by trivial heuristic after 0.0 seconds, objective value -6.000000e+02\n",
       "presolving:\n",
       "(round 1, fast)       4 del vars, 0 del conss, 0 add conss, 0 chg bounds, 0 chg sides, 0 chg coeffs, 0 upgd conss, 0 impls, 0 clqs\n",
       "(round 2, exhaustive) 4 del vars, 0 del conss, 0 add conss, 0 chg bounds, 0 chg sides, 0 chg coeffs, 1 upgd conss, 0 impls, 0 clqs\n",
@@ -419,30 +421,28 @@
       "Solving Nodes      : 0\n",
       "Primal Bound       : -7.53400000000000e+03 (3 solutions)\n",
       "Dual Bound         : -7.53400000000000e+03\n",
-      "Gap                : 0.00 %\n",
-      "\n",
-      "(CVXPY) Apr 25 10:40:09 AM: Problem status: optimal\n"
+      "Gap                : 0.00 %\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Optimal value: 7.534e+03\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Optimal value: 7.534e+03\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Compilation took 8.441e-03 seconds\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Compilation took 8.368e-03 seconds\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:09 AM: Solver (including time spent in interface) took 3.624e-03 seconds\n"
+      "(CVXPY) Apr 25 10:46:32 AM: Solver (including time spent in interface) took 3.592e-03 seconds\n"
      ]
     },
     {
diff --git a/jupyter_execute/guide/intro/multi-commodity-network-flows.ipynb b/jupyter_execute/guide/intro/multi-commodity-network-flows.ipynb
index 65db58cb..e98057a6 100644
--- a/jupyter_execute/guide/intro/multi-commodity-network-flows.ipynb
+++ b/jupyter_execute/guide/intro/multi-commodity-network-flows.ipynb
@@ -145,7 +145,7 @@
        "</svg>\n"
       ],
       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7f7b11a05090>"
+       "<graphviz.graphs.Digraph at 0x7f7f761fc1d0>"
       ]
      },
      "execution_count": 2,
@@ -304,7 +304,7 @@
        "</svg>\n"
       ],
       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7f7b13fa3c90>"
+       "<graphviz.graphs.Digraph at 0x7f7f787e3d90>"
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      "execution_count": 3,
@@ -404,29 +404,29 @@
       "                                     CVXPY                                     \n",
       "                                     v1.4.3                                    \n",
       "===============================================================================\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Your problem has 20 variables, 5 constraints, and 0 parameters.\n",
-      "(CVXPY) Apr 25 10:40:10 AM: It is compliant with the following grammars: DCP, DQCP\n",
-      "(CVXPY) Apr 25 10:40:10 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n",
-      "(CVXPY) Apr 25 10:40:10 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Your problem is compiled with the CPP canonicalization backend.\n",
+      "(CVXPY) Apr 25 10:46:33 AM: Your problem has 20 variables, 5 constraints, and 0 parameters.\n",
+      "(CVXPY) Apr 25 10:46:33 AM: It is compliant with the following grammars: DCP, DQCP\n",
+      "(CVXPY) Apr 25 10:46:33 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n",
+      "(CVXPY) Apr 25 10:46:33 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n",
+      "(CVXPY) Apr 25 10:46:33 AM: Your problem is compiled with the CPP canonicalization backend.\n",
       "-------------------------------------------------------------------------------\n",
       "                                  Compilation                                  \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Compiling problem (target solver=SCIP).\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIP\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Applying reduction Dcp2Cone\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Applying reduction CvxAttr2Constr\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Applying reduction ConeMatrixStuffing\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Applying reduction SCIP\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Finished problem compilation (took 1.412e-02 seconds).\n",
+      "(CVXPY) Apr 25 10:46:33 AM: Compiling problem (target solver=SCIP).\n",
+      "(CVXPY) Apr 25 10:46:33 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIP\n",
+      "(CVXPY) Apr 25 10:46:33 AM: Applying reduction Dcp2Cone\n",
+      "(CVXPY) Apr 25 10:46:33 AM: Applying reduction CvxAttr2Constr\n",
+      "(CVXPY) Apr 25 10:46:33 AM: Applying reduction ConeMatrixStuffing\n",
+      "(CVXPY) Apr 25 10:46:33 AM: Applying reduction SCIP\n",
+      "(CVXPY) Apr 25 10:46:33 AM: Finished problem compilation (took 1.440e-02 seconds).\n",
       "-------------------------------------------------------------------------------\n",
       "                                Numerical solver                               \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Invoking solver SCIP  to obtain a solution.\n",
+      "(CVXPY) Apr 25 10:46:33 AM: Invoking solver SCIP  to obtain a solution.\n",
       "-------------------------------------------------------------------------------\n",
       "                                    Summary                                    \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Problem status: optimal\n",
+      "(CVXPY) Apr 25 10:46:33 AM: Problem status: optimal\n",
       "presolving:\n",
       "   (0.0s) symmetry computation started: requiring (bin +, int +, cont +), (fixed: bin -, int -, cont -)\n",
       "   (0.0s) no symmetry present (symcode time: 0.00)\n",
@@ -447,37 +447,37 @@
       "Primal Bound       : -1.90000000000000e+02 (1 solutions)\n",
       "Dual Bound         : -1.90000000000000e+02\n",
       "Gap                : 0.00 %\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Optimal value: -1.900e+02\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Compilation took 1.412e-02 seconds\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Solver (including time spent in interface) took 6.421e-03 seconds\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Optimal value: -1.900e+02\n",
+      "(CVXPY) Apr 25 10:46:33 AM: Compilation took 1.440e-02 seconds\n",
+      "(CVXPY) Apr 25 10:46:33 AM: Solver (including time spent in interface) took 6.373e-03 seconds\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: It is compliant with the following grammars: DCP, DQCP\n"
+      "(CVXPY) Apr 25 10:46:33 AM: It is compliant with the following grammars: DCP, DQCP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
+      "(CVXPY) Apr 25 10:46:33 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:46:33 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: Your problem is compiled with the CPP canonicalization backend.\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Your problem is compiled with the CPP canonicalization backend.\n"
      ]
     },
     {
@@ -487,49 +487,49 @@
       "-------------------------------------------------------------------------------\n",
       "                                  Compilation                                  \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Compiling problem (target solver=SCIP).\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Compiling problem (target solver=SCIP).\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIP\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: Applying reduction Dcp2Cone\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Applying reduction Dcp2Cone\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: Applying reduction CvxAttr2Constr\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Applying reduction CvxAttr2Constr\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: Applying reduction ConeMatrixStuffing\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Applying reduction ConeMatrixStuffing\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: Applying reduction SCIP\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Applying reduction SCIP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: Finished problem compilation (took 1.412e-02 seconds).\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Finished problem compilation (took 1.440e-02 seconds).\n"
      ]
     },
     {
@@ -539,7 +539,7 @@
       "-------------------------------------------------------------------------------\n",
       "                                Numerical solver                               \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Invoking solver SCIP  to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Invoking solver SCIP  to obtain a solution.\n"
      ]
     },
     {
@@ -549,7 +549,13 @@
       "-------------------------------------------------------------------------------\n",
       "                                    Summary                                    \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:10 AM: Problem status: optimal\n",
+      "(CVXPY) Apr 25 10:46:33 AM: Problem status: optimal\n"
+     ]
+    },
+    {
+     "name": "stdout",
+     "output_type": "stream",
+     "text": [
       "presolving:\n",
       "   (0.0s) symmetry computation started: requiring (bin +, int +, cont +), (fixed: bin -, int -, cont -)\n",
       "   (0.0s) no symmetry present (symcode time: 0.00)\n",
@@ -569,28 +575,22 @@
       "Solving Nodes      : 1\n",
       "Primal Bound       : -1.90000000000000e+02 (1 solutions)\n",
       "Dual Bound         : -1.90000000000000e+02\n",
-      "Gap                : 0.00 %\n"
-     ]
-    },
-    {
-     "name": "stdout",
-     "output_type": "stream",
-     "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: Optimal value: -1.900e+02\n"
+      "Gap                : 0.00 %\n",
+      "(CVXPY) Apr 25 10:46:33 AM: Optimal value: -1.900e+02\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: Compilation took 1.412e-02 seconds\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Compilation took 1.440e-02 seconds\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:10 AM: Solver (including time spent in interface) took 6.421e-03 seconds\n"
+      "(CVXPY) Apr 25 10:46:33 AM: Solver (including time spent in interface) took 6.373e-03 seconds\n"
      ]
     },
     {
diff --git a/jupyter_execute/guide/intro/prior-knowledge.ipynb b/jupyter_execute/guide/intro/prior-knowledge.ipynb
index 14e81205..a2041141 100644
--- a/jupyter_execute/guide/intro/prior-knowledge.ipynb
+++ b/jupyter_execute/guide/intro/prior-knowledge.ipynb
@@ -125,7 +125,7 @@
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@@ -227,7 +227,7 @@
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       ],
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-       "<graphviz.graphs.Digraph at 0x7fd7fcf00390>"
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@@ -331,7 +331,7 @@
        "</svg>\n"
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@@ -595,7 +595,7 @@
        "</svg>\n"
       ],
       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7fd7fcd5a390>"
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@@ -757,7 +757,7 @@
        "</svg>\n"
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      "execution_count": 16,
@@ -806,31 +806,31 @@
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-       "<!-- A -->\n",
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-       "<title>A</title>\n",
+       "<title>B</title>\n",
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-       "<text text-anchor=\"middle\" x=\"126\" y=\"-244.3\" font-family=\"Times,serif\" font-size=\"14.00\">A</text>\n",
+       "<text text-anchor=\"middle\" x=\"126\" y=\"-244.3\" font-family=\"Times,serif\" font-size=\"14.00\">B</text>\n",
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        "</g>\n",
-       "<!-- A&#45;&gt;e_0_center -->\n",
+       "<!-- B&#45;&gt;e_0_center -->\n",
        "<g id=\"edge1\" class=\"edge\">\n",
-       "<title>A&#45;&gt;e_0_center</title>\n",
+       "<title>B&#45;&gt;e_0_center</title>\n",
        "<path fill=\"none\" stroke=\"black\" d=\"M118.48,-231.54C112.11,-218.45 103.52,-200.8 100.3,-194.17\"/>\n",
        "</g>\n",
-       "<!-- B -->\n",
+       "<!-- A -->\n",
        "<g id=\"node2\" class=\"node\">\n",
-       "<title>B</title>\n",
+       "<title>A</title>\n",
        "<ellipse fill=\"none\" stroke=\"black\" cx=\"72\" cy=\"-248\" rx=\"18\" ry=\"18\"/>\n",
-       "<text text-anchor=\"middle\" x=\"72\" y=\"-244.3\" font-family=\"Times,serif\" font-size=\"14.00\">B</text>\n",
+       "<text text-anchor=\"middle\" x=\"72\" y=\"-244.3\" font-family=\"Times,serif\" font-size=\"14.00\">A</text>\n",
        "</g>\n",
-       "<!-- B&#45;&gt;e_0_center -->\n",
+       "<!-- A&#45;&gt;e_0_center -->\n",
        "<g id=\"edge2\" class=\"edge\">\n",
-       "<title>B&#45;&gt;e_0_center</title>\n",
+       "<title>A&#45;&gt;e_0_center</title>\n",
        "<path fill=\"none\" stroke=\"black\" d=\"M79.52,-231.54C85.89,-218.45 94.48,-200.8 97.7,-194.17\"/>\n",
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@@ -917,30 +917,30 @@
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        "<title>e_2_source</title>\n",
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+       "<ellipse fill=\"black\" stroke=\"black\" cx=\"72\" cy=\"-303.8\" rx=\"1.8\" ry=\"1.8\"/>\n",
        "</g>\n",
        "<!-- e_2_source&#45;&gt;A -->\n",
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        "<title>e_2_source&#45;&gt;A</title>\n",
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-       "<polygon fill=\"black\" stroke=\"black\" points=\"129.5,-276.26 126,-266.26 122.5,-276.26 129.5,-276.26\"/>\n",
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        "<title>e_3_source</title>\n",
-       "<ellipse fill=\"black\" stroke=\"black\" cx=\"72\" cy=\"-303.8\" rx=\"1.8\" ry=\"1.8\"/>\n",
+       "<ellipse fill=\"black\" stroke=\"black\" cx=\"126\" cy=\"-303.8\" rx=\"1.8\" ry=\"1.8\"/>\n",
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diff --git a/jupyter_execute/guide/metabolism/flux-balance-analysis.ipynb b/jupyter_execute/guide/metabolism/flux-balance-analysis.ipynb
index 3c9de426..25e56615 100644
--- a/jupyter_execute/guide/metabolism/flux-balance-analysis.ipynb
+++ b/jupyter_execute/guide/metabolism/flux-balance-analysis.ipynb
@@ -97,7 +97,7 @@
        "                <td><strong>Name</strong></td><td>Biomass Objective Function with GAM</td>\n",
        "            </tr><tr>\n",
        "                <td><strong>Memory address</strong></td>\n",
-       "                <td>0x7f4ff9f4e350</td>\n",
+       "                <td>0x7fefbc1edfd0</td>\n",
        "            </tr><tr>\n",
        "                <td><strong>Stoichiometry</strong></td>\n",
        "                <td>\n",
@@ -115,7 +115,7 @@
        "        "
       ],
       "text/plain": [
-       "<Reaction Biomass_Ecoli_core at 0x7f4ff9f4e350>"
+       "<Reaction Biomass_Ecoli_core at 0x7fefbc1edfd0>"
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      },
      "execution_count": 2,
@@ -138,7 +138,7 @@
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "<Solution 0.874 at 0x7f4ffa0b3750>\n"
+      "<Solution 0.874 at 0x7fefbc0acf50>\n"
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diff --git a/jupyter_execute/guide/metabolism/imat.ipynb b/jupyter_execute/guide/metabolism/imat.ipynb
index 84af6d9a..ffc923f6 100644
--- a/jupyter_execute/guide/metabolism/imat.ipynb
+++ b/jupyter_execute/guide/metabolism/imat.ipynb
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diff --git a/jupyter_execute/guide/metabolism/sparse-fba.ipynb b/jupyter_execute/guide/metabolism/sparse-fba.ipynb
index addb5942..62e608c4 100644
--- a/jupyter_execute/guide/metabolism/sparse-fba.ipynb
+++ b/jupyter_execute/guide/metabolism/sparse-fba.ipynb
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        "<!-- e_10_center&#45;&gt;adp_c -->\n",
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        "<!-- e_10_center&#45;&gt;pi_c -->\n",
-       "<g id=\"edge44\" class=\"edge\">\n",
+       "<g id=\"edge42\" class=\"edge\">\n",
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        "<!-- e_11_center&#45;&gt;h_c -->\n",
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+       "<g id=\"edge50\" class=\"edge\">\n",
        "<title>e_11_center&#45;&gt;h_c</title>\n",
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        "<!-- e_11_center&#45;&gt;atp_c -->\n",
-       "<g id=\"edge48\" class=\"edge\">\n",
+       "<g id=\"edge49\" class=\"edge\">\n",
        "<title>e_11_center&#45;&gt;atp_c</title>\n",
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        "<!-- e_11_center&#45;&gt;h2o_c -->\n",
-       "<g id=\"edge50\" class=\"edge\">\n",
+       "<g id=\"edge48\" class=\"edge\">\n",
        "<title>e_11_center&#45;&gt;h2o_c</title>\n",
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        "</g>\n",
-       "<!-- e4p_c -->\n",
+       "<!-- gln__L_c -->\n",
        "<g id=\"node36\" class=\"node\">\n",
-       "<title>e4p_c</title>\n",
-       "<ellipse fill=\"none\" stroke=\"black\" cx=\"2017.92\" cy=\"-999.87\" rx=\"18\" ry=\"18\"/>\n",
-       "<text text-anchor=\"middle\" x=\"2017.92\" y=\"-996.17\" font-family=\"Times,serif\" font-size=\"14.00\">e4p_c</text>\n",
+       "<title>gln__L_c</title>\n",
+       "<ellipse fill=\"none\" stroke=\"black\" cx=\"748.84\" cy=\"-827.41\" rx=\"18\" ry=\"18\"/>\n",
+       "<text text-anchor=\"middle\" x=\"748.84\" y=\"-823.71\" font-family=\"Times,serif\" font-size=\"14.00\">gln__L_c</text>\n",
        "</g>\n",
-       "<!-- e4p_c&#45;&gt;e_12_center -->\n",
+       "<!-- gln__L_c&#45;&gt;e_12_center -->\n",
        "<g id=\"edge51\" class=\"edge\">\n",
-       "<title>e4p_c&#45;&gt;e_12_center</title>\n",
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-       "<!-- e4p_c&#45;&gt;e_93_center -->\n",
-       "<g id=\"edge346\" class=\"edge\">\n",
-       "<title>e4p_c&#45;&gt;e_93_center</title>\n",
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-       "</g>\n",
-       "<!-- glu__L_c -->\n",
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-       "<title>glu__L_c</title>\n",
-       "<ellipse fill=\"none\" stroke=\"black\" cx=\"1468.27\" cy=\"-965.32\" rx=\"18\" ry=\"18\"/>\n",
-       "<text text-anchor=\"middle\" x=\"1468.27\" y=\"-961.62\" font-family=\"Times,serif\" font-size=\"14.00\">glu__L_c</text>\n",
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-       "<!-- glu__L_c&#45;&gt;e_12_center -->\n",
-       "<g id=\"edge52\" class=\"edge\">\n",
-       "<title>glu__L_c&#45;&gt;e_12_center</title>\n",
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-       "<!-- glu__L_c&#45;&gt;e_50_center -->\n",
-       "<g id=\"edge162\" class=\"edge\">\n",
-       "<title>glu__L_c&#45;&gt;e_50_center</title>\n",
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-       "<title>glu__L_c&#45;&gt;e_52_center</title>\n",
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-       "<!-- pep_c -->\n",
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-       "<title>pep_c</title>\n",
-       "<ellipse fill=\"none\" stroke=\"black\" cx=\"1814.6\" cy=\"-1320.53\" rx=\"18\" ry=\"18\"/>\n",
-       "<text text-anchor=\"middle\" x=\"1814.6\" y=\"-1316.83\" font-family=\"Times,serif\" font-size=\"14.00\">pep_c</text>\n",
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-       "<title>pep_c&#45;&gt;e_12_center</title>\n",
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+       "<title>gln__L_c&#45;&gt;e_12_center</title>\n",
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+       "<!-- gln__L_c&#45;&gt;e_53_center -->\n",
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+       "<title>gln__L_c&#45;&gt;e_53_center</title>\n",
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+       "<title>gln__L_c&#45;&gt;e_54_center</title>\n",
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        "<!-- 3pg_c -->\n",
-       "<g id=\"node39\" class=\"node\">\n",
+       "<g id=\"node37\" class=\"node\">\n",
        "<title>3pg_c</title>\n",
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-       "<text text-anchor=\"middle\" x=\"1919.69\" y=\"-1347.71\" font-family=\"Times,serif\" font-size=\"14.00\">3pg_c</text>\n",
+       "<ellipse fill=\"none\" stroke=\"black\" cx=\"815.53\" cy=\"-556.84\" rx=\"18\" ry=\"18\"/>\n",
+       "<text text-anchor=\"middle\" x=\"815.53\" y=\"-553.14\" font-family=\"Times,serif\" font-size=\"14.00\">3pg_c</text>\n",
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        "<!-- 3pg_c&#45;&gt;e_12_center -->\n",
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+       "</g>\n",
+       "<!-- f6p_c -->\n",
+       "<g id=\"node38\" class=\"node\">\n",
+       "<title>f6p_c</title>\n",
+       "<ellipse fill=\"none\" stroke=\"black\" cx=\"1038.14\" cy=\"-546.2\" rx=\"18\" ry=\"18\"/>\n",
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+       "</g>\n",
+       "<!-- f6p_c&#45;&gt;e_12_center -->\n",
+       "<g id=\"edge53\" class=\"edge\">\n",
+       "<title>f6p_c&#45;&gt;e_12_center</title>\n",
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+       "</g>\n",
+       "<!-- f6p_c&#45;&gt;e_71_center -->\n",
+       "<g id=\"edge258\" class=\"edge\">\n",
+       "<title>f6p_c&#45;&gt;e_71_center</title>\n",
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        "<!-- pyr_c -->\n",
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+       "<g id=\"node39\" class=\"node\">\n",
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@@ -3129,36 +3129,36 @@
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-       "<!-- e4p_c -->\n",
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-       "<text text-anchor=\"middle\" x=\"2017.92\" y=\"-996.17\" font-family=\"Times,serif\" font-size=\"14.00\">e4p_c</text>\n",
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        "<!-- 3pg_c -->\n",
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+       "<!-- f6p_c -->\n",
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        "<!-- pyr_c -->\n",
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-       "<!-- g6p_c -->\n",
+       "<!-- r5p_c -->\n",
+       "<g id=\"node40\" class=\"node\">\n",
+       "<title>r5p_c</title>\n",
+       "<ellipse fill=\"none\" stroke=\"black\" cx=\"1123.47\" cy=\"-472.63\" rx=\"18\" ry=\"18\"/>\n",
+       "<text text-anchor=\"middle\" x=\"1123.47\" y=\"-468.93\" font-family=\"Times,serif\" font-size=\"14.00\">r5p_c</text>\n",
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+       "<!-- r5p_c&#45;&gt;e_12_center -->\n",
+       "<g id=\"edge56\" class=\"edge\">\n",
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+       "</g>\n",
+       "<!-- ru5p__D_c -->\n",
+       "<g id=\"node122\" class=\"node\">\n",
+       "<title>ru5p__D_c</title>\n",
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+       "</g>\n",
+       "<!-- r5p_c&#45;&gt;ru5p__D_c -->\n",
+       "<g id=\"edge312\" class=\"edge\">\n",
+       "<title>r5p_c&#45;&gt;ru5p__D_c</title>\n",
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      "execution_count": 10,
diff --git a/jupyter_execute/guide/networks/steiner-trees.ipynb b/jupyter_execute/guide/networks/steiner-trees.ipynb
index e977c2c7..e46d0e38 100644
--- a/jupyter_execute/guide/networks/steiner-trees.ipynb
+++ b/jupyter_execute/guide/networks/steiner-trees.ipynb
@@ -254,61 +254,61 @@
       "                                     CVXPY                                     \n",
       "                                     v1.4.3                                    \n",
       "===============================================================================\n",
-      "(CVXPY) Apr 25 10:40:58 AM: Your problem has 310 variables, 7 constraints, and 0 parameters.\n",
-      "(CVXPY) Apr 25 10:40:58 AM: It is compliant with the following grammars: DCP, DQCP\n",
-      "(CVXPY) Apr 25 10:40:58 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n",
-      "(CVXPY) Apr 25 10:40:58 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n",
-      "(CVXPY) Apr 25 10:40:58 AM: Your problem is compiled with the CPP canonicalization backend.\n",
+      "(CVXPY) Apr 25 10:47:26 AM: Your problem has 310 variables, 7 constraints, and 0 parameters.\n",
+      "(CVXPY) Apr 25 10:47:26 AM: It is compliant with the following grammars: DCP, DQCP\n",
+      "(CVXPY) Apr 25 10:47:26 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n",
+      "(CVXPY) Apr 25 10:47:26 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n",
+      "(CVXPY) Apr 25 10:47:26 AM: Your problem is compiled with the CPP canonicalization backend.\n",
       "-------------------------------------------------------------------------------\n",
       "                                  Compilation                                  \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:58 AM: Compiling problem (target solver=SCIPY).\n",
-      "(CVXPY) Apr 25 10:40:58 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIPY\n",
-      "(CVXPY) Apr 25 10:40:58 AM: Applying reduction Dcp2Cone\n",
-      "(CVXPY) Apr 25 10:40:58 AM: Applying reduction CvxAttr2Constr\n",
-      "(CVXPY) Apr 25 10:40:58 AM: Applying reduction ConeMatrixStuffing\n",
-      "(CVXPY) Apr 25 10:40:58 AM: Applying reduction SCIPY\n",
-      "(CVXPY) Apr 25 10:40:58 AM: Finished problem compilation (took 1.355e-02 seconds).\n",
+      "(CVXPY) Apr 25 10:47:26 AM: Compiling problem (target solver=SCIPY).\n",
+      "(CVXPY) Apr 25 10:47:26 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIPY\n",
+      "(CVXPY) Apr 25 10:47:26 AM: Applying reduction Dcp2Cone\n",
+      "(CVXPY) Apr 25 10:47:26 AM: Applying reduction CvxAttr2Constr\n",
+      "(CVXPY) Apr 25 10:47:26 AM: Applying reduction ConeMatrixStuffing\n",
+      "(CVXPY) Apr 25 10:47:26 AM: Applying reduction SCIPY\n",
+      "(CVXPY) Apr 25 10:47:26 AM: Finished problem compilation (took 1.438e-02 seconds).\n",
       "-------------------------------------------------------------------------------\n",
       "                                Numerical solver                               \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:58 AM: Invoking solver SCIPY  to obtain a solution.\n",
+      "(CVXPY) Apr 25 10:47:26 AM: Invoking solver SCIPY  to obtain a solution.\n",
       "Solver terminated with message: Optimization terminated successfully. (HiGHS Status 7: Optimal)\n",
       "-------------------------------------------------------------------------------\n",
       "                                    Summary                                    \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Problem status: optimal\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Optimal value: 4.100e+01\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Compilation took 1.355e-02 seconds\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Solver (including time spent in interface) took 3.391e+01 seconds\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Problem status: optimal\n",
+      "(CVXPY) Apr 25 10:48:00 AM: Optimal value: 4.100e+01\n",
+      "(CVXPY) Apr 25 10:48:00 AM: Compilation took 1.438e-02 seconds\n",
+      "(CVXPY) Apr 25 10:48:00 AM: Solver (including time spent in interface) took 3.394e+01 seconds\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:58 AM: It is compliant with the following grammars: DCP, DQCP\n"
+      "(CVXPY) Apr 25 10:47:26 AM: It is compliant with the following grammars: DCP, DQCP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:58 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
+      "(CVXPY) Apr 25 10:47:26 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:58 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:47:26 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:58 AM: Your problem is compiled with the CPP canonicalization backend.\n"
+      "(CVXPY) Apr 25 10:47:26 AM: Your problem is compiled with the CPP canonicalization backend.\n"
      ]
     },
     {
@@ -318,49 +318,49 @@
       "-------------------------------------------------------------------------------\n",
       "                                  Compilation                                  \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:58 AM: Compiling problem (target solver=SCIPY).\n"
+      "(CVXPY) Apr 25 10:47:26 AM: Compiling problem (target solver=SCIPY).\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:58 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIPY\n"
+      "(CVXPY) Apr 25 10:47:26 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIPY\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:58 AM: Applying reduction Dcp2Cone\n"
+      "(CVXPY) Apr 25 10:47:26 AM: Applying reduction Dcp2Cone\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:58 AM: Applying reduction CvxAttr2Constr\n"
+      "(CVXPY) Apr 25 10:47:26 AM: Applying reduction CvxAttr2Constr\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:58 AM: Applying reduction ConeMatrixStuffing\n"
+      "(CVXPY) Apr 25 10:47:26 AM: Applying reduction ConeMatrixStuffing\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:58 AM: Applying reduction SCIPY\n"
+      "(CVXPY) Apr 25 10:47:26 AM: Applying reduction SCIPY\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:40:58 AM: Finished problem compilation (took 1.355e-02 seconds).\n"
+      "(CVXPY) Apr 25 10:47:26 AM: Finished problem compilation (took 1.438e-02 seconds).\n"
      ]
     },
     {
@@ -370,7 +370,7 @@
       "-------------------------------------------------------------------------------\n",
       "                                Numerical solver                               \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:40:58 AM: Invoking solver SCIPY  to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:47:26 AM: Invoking solver SCIPY  to obtain a solution.\n"
      ]
     },
     {
@@ -381,28 +381,28 @@
       "-------------------------------------------------------------------------------\n",
       "                                    Summary                                    \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Problem status: optimal\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Problem status: optimal\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: Optimal value: 4.100e+01\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Optimal value: 4.100e+01\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: Compilation took 1.355e-02 seconds\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Compilation took 1.438e-02 seconds\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: Solver (including time spent in interface) took 3.391e+01 seconds\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Solver (including time spent in interface) took 3.394e+01 seconds\n"
      ]
     },
     {
@@ -616,7 +616,7 @@
        "</svg>\n"
       ],
       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7f51a9ea9e10>"
+       "<graphviz.graphs.Digraph at 0x7fe7822d6090>"
       ]
      },
      "execution_count": 6,
@@ -673,33 +673,33 @@
       "                                     CVXPY                                     \n",
       "                                     v1.4.3                                    \n",
       "===============================================================================\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Your problem has 670 variables, 17 constraints, and 0 parameters.\n",
-      "(CVXPY) Apr 25 10:41:32 AM: It is compliant with the following grammars: DCP, DQCP\n",
-      "(CVXPY) Apr 25 10:41:32 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n",
-      "(CVXPY) Apr 25 10:41:32 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Your problem is compiled with the CPP canonicalization backend.\n",
+      "(CVXPY) Apr 25 10:48:00 AM: Your problem has 670 variables, 17 constraints, and 0 parameters.\n",
+      "(CVXPY) Apr 25 10:48:00 AM: It is compliant with the following grammars: DCP, DQCP\n",
+      "(CVXPY) Apr 25 10:48:00 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n",
+      "(CVXPY) Apr 25 10:48:00 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n",
+      "(CVXPY) Apr 25 10:48:00 AM: Your problem is compiled with the CPP canonicalization backend.\n",
       "-------------------------------------------------------------------------------\n",
       "                                  Compilation                                  \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Compiling problem (target solver=SCIPY).\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIPY\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Applying reduction Dcp2Cone\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Applying reduction CvxAttr2Constr\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Applying reduction ConeMatrixStuffing\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Applying reduction SCIPY\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Finished problem compilation (took 2.558e-02 seconds).\n",
+      "(CVXPY) Apr 25 10:48:00 AM: Compiling problem (target solver=SCIPY).\n",
+      "(CVXPY) Apr 25 10:48:00 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIPY\n",
+      "(CVXPY) Apr 25 10:48:00 AM: Applying reduction Dcp2Cone\n",
+      "(CVXPY) Apr 25 10:48:00 AM: Applying reduction CvxAttr2Constr\n",
+      "(CVXPY) Apr 25 10:48:00 AM: Applying reduction ConeMatrixStuffing\n",
+      "(CVXPY) Apr 25 10:48:00 AM: Applying reduction SCIPY\n",
+      "(CVXPY) Apr 25 10:48:00 AM: Finished problem compilation (took 2.385e-02 seconds).\n",
       "-------------------------------------------------------------------------------\n",
       "                                Numerical solver                               \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Invoking solver SCIPY  to obtain a solution.\n",
+      "(CVXPY) Apr 25 10:48:00 AM: Invoking solver SCIPY  to obtain a solution.\n",
       "Solver terminated with message: Optimization terminated successfully. (HiGHS Status 7: Optimal)\n",
       "-------------------------------------------------------------------------------\n",
       "                                    Summary                                    \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:49 AM: Problem status: optimal\n",
-      "(CVXPY) Apr 25 10:41:49 AM: Optimal value: 4.100e+01\n",
-      "(CVXPY) Apr 25 10:41:49 AM: Compilation took 2.558e-02 seconds\n",
-      "(CVXPY) Apr 25 10:41:49 AM: Solver (including time spent in interface) took 1.722e+01 seconds\n",
+      "(CVXPY) Apr 25 10:48:17 AM: Problem status: optimal\n",
+      "(CVXPY) Apr 25 10:48:17 AM: Optimal value: 4.100e+01\n",
+      "(CVXPY) Apr 25 10:48:17 AM: Compilation took 2.385e-02 seconds\n",
+      "(CVXPY) Apr 25 10:48:17 AM: Solver (including time spent in interface) took 1.726e+01 seconds\n",
       "Optimal value: 41.0\n"
      ]
     },
@@ -707,28 +707,28 @@
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: It is compliant with the following grammars: DCP, DQCP\n"
+      "(CVXPY) Apr 25 10:48:00 AM: It is compliant with the following grammars: DCP, DQCP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
+      "(CVXPY) Apr 25 10:48:00 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:48:00 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: Your problem is compiled with the CPP canonicalization backend.\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Your problem is compiled with the CPP canonicalization backend.\n"
      ]
     },
     {
@@ -738,49 +738,49 @@
       "-------------------------------------------------------------------------------\n",
       "                                  Compilation                                  \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Compiling problem (target solver=SCIPY).\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Compiling problem (target solver=SCIPY).\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIPY\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIPY\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: Applying reduction Dcp2Cone\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Applying reduction Dcp2Cone\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: Applying reduction CvxAttr2Constr\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Applying reduction CvxAttr2Constr\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: Applying reduction ConeMatrixStuffing\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Applying reduction ConeMatrixStuffing\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: Applying reduction SCIPY\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Applying reduction SCIPY\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:32 AM: Finished problem compilation (took 2.558e-02 seconds).\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Finished problem compilation (took 2.385e-02 seconds).\n"
      ]
     },
     {
@@ -790,7 +790,7 @@
       "-------------------------------------------------------------------------------\n",
       "                                Numerical solver                               \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:32 AM: Invoking solver SCIPY  to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:48:00 AM: Invoking solver SCIPY  to obtain a solution.\n"
      ]
     },
     {
@@ -801,28 +801,28 @@
       "-------------------------------------------------------------------------------\n",
       "                                    Summary                                    \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:49 AM: Problem status: optimal\n"
+      "(CVXPY) Apr 25 10:48:17 AM: Problem status: optimal\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:49 AM: Optimal value: 4.100e+01\n"
+      "(CVXPY) Apr 25 10:48:17 AM: Optimal value: 4.100e+01\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:49 AM: Compilation took 2.558e-02 seconds\n"
+      "(CVXPY) Apr 25 10:48:17 AM: Compilation took 2.385e-02 seconds\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:49 AM: Solver (including time spent in interface) took 1.722e+01 seconds\n"
+      "(CVXPY) Apr 25 10:48:17 AM: Solver (including time spent in interface) took 1.726e+01 seconds\n"
      ]
     },
     {
@@ -1021,7 +1021,7 @@
        "</svg>\n"
       ],
       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7f51c813ac10>"
+       "<graphviz.graphs.Digraph at 0x7fe782117a90>"
       ]
      },
      "execution_count": 8,
diff --git a/jupyter_execute/guide/signaling/carnival.ipynb b/jupyter_execute/guide/signaling/carnival.ipynb
index fdaf7d19..0eab26ac 100644
--- a/jupyter_execute/guide/signaling/carnival.ipynb
+++ b/jupyter_execute/guide/signaling/carnival.ipynb
@@ -171,7 +171,7 @@
        "</svg>\n"
       ],
       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7f99e32f8550>"
+       "<graphviz.graphs.Digraph at 0x7f6ca6712910>"
       ]
      },
      "execution_count": 2,
@@ -204,43 +204,41 @@
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : 2/2 inputs mapped to the graph\n",
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : 2/2 outputs mapped to the graph\n",
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : Pruning the graph with size: V x E = (6, 6)...\n",
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : Finished. Final size: V x E = (6, 6).\n",
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : 2/2 inputs after pruning.\n",
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : 2/2 outputs after pruning.\n",
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : Converting into a flow graph...\n",
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : Creating a network flow problem...\n",
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : Preprocess completed.\n",
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : 2/2 inputs mapped to the graph\n",
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : 2/2 outputs mapped to the graph\n",
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : Pruning the graph with size: V x E = (6, 6)...\n",
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : Finished. Final size: V x E = (6, 6).\n",
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : 2/2 inputs after pruning.\n",
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : 2/2 outputs after pruning.\n",
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : Converting into a flow graph...\n",
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : Creating a network flow problem...\n",
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : Preprocess completed.\n",
       "===============================================================================\n",
       "                                     CVXPY                                     \n",
       "                                     v1.4.3                                    \n",
       "===============================================================================\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Your problem has 86 variables, 20 constraints, and 0 parameters.\n",
-      "(CVXPY) Apr 25 10:41:51 AM: It is compliant with the following grammars: DCP, DQCP\n",
-      "(CVXPY) Apr 25 10:41:51 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n",
-      "(CVXPY) Apr 25 10:41:51 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Your problem is compiled with the CPP canonicalization backend.\n",
+      "(CVXPY) Apr 25 10:48:19 AM: Your problem has 86 variables, 20 constraints, and 0 parameters.\n",
+      "(CVXPY) Apr 25 10:48:19 AM: It is compliant with the following grammars: DCP, DQCP\n",
+      "(CVXPY) Apr 25 10:48:19 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n",
+      "(CVXPY) Apr 25 10:48:19 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n",
+      "(CVXPY) Apr 25 10:48:19 AM: Your problem is compiled with the CPP canonicalization backend.\n",
       "-------------------------------------------------------------------------------\n",
       "                                  Compilation                                  \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Compiling problem (target solver=SCIP).\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIP\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Applying reduction Dcp2Cone\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Applying reduction CvxAttr2Constr\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Applying reduction ConeMatrixStuffing\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Applying reduction SCIP\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Finished problem compilation (took 2.805e-02 seconds).\n",
+      "(CVXPY) Apr 25 10:48:19 AM: Compiling problem (target solver=SCIP).\n",
+      "(CVXPY) Apr 25 10:48:19 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIP\n",
+      "(CVXPY) Apr 25 10:48:19 AM: Applying reduction Dcp2Cone\n",
+      "(CVXPY) Apr 25 10:48:19 AM: Applying reduction CvxAttr2Constr\n",
+      "(CVXPY) Apr 25 10:48:19 AM: Applying reduction ConeMatrixStuffing\n",
+      "(CVXPY) Apr 25 10:48:19 AM: Applying reduction SCIP\n",
+      "(CVXPY) Apr 25 10:48:19 AM: Finished problem compilation (took 3.197e-02 seconds).\n",
       "-------------------------------------------------------------------------------\n",
       "                                Numerical solver                               \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Invoking solver SCIP  to obtain a solution.\n",
+      "(CVXPY) Apr 25 10:48:19 AM: Invoking solver SCIP  to obtain a solution.\n",
       "-------------------------------------------------------------------------------\n",
       "                                    Summary                                    \n",
-      "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Problem status: optimal\n",
-      "presolving:\n",
+      "-------------------------------------------------------------------------------presolving:\n",
       "(round 1, fast)       36 del vars, 95 del conss, 0 add conss, 48 chg bounds, 1 chg sides, 23 chg coeffs, 0 upgd conss, 0 impls, 28 clqs\n",
       "(round 2, fast)       54 del vars, 129 del conss, 0 add conss, 52 chg bounds, 9 chg sides, 31 chg coeffs, 0 upgd conss, 0 impls, 20 clqs\n",
       "(round 3, fast)       63 del vars, 145 del conss, 0 add conss, 52 chg bounds, 11 chg sides, 33 chg coeffs, 0 upgd conss, 0 impls, 18 clqs\n",
@@ -271,14 +269,13 @@
       "Presolving Time: 0.00\n",
       "\n",
       " time | node  | left  |LP iter|LP it/n|mem/heur|mdpt |vars |cons |rows |cuts |sepa|confs|strbr|  dualbound   | primalbound  |  gap   | compl. \n",
-      "p 0.0s|     1 |     0 |     1 |     - |  clique|   0 |  27 |  45 |  42 |   0 |  0 |   0 |   0 |-3.500000e+00 | 1.000000e-01 |    Inf | unknown\n",
-      "p 0.0s|     1 |     0 |     1 |     - |   locks|   0 |  27 |  45 |  42 |   0 |  0 |   0 |   0 |-3.500000e+00 |-6.000000e-01 | 483.33%| unknown\n",
-      "p 0.0s|     1 |     0 |     1 |     - | vbounds|   0 |  27 |  46 |  42 |   0 |  0 |   1 |   0 |-3.500000e+00 |-1.600000e+00 | 118.75%| unknown\n",
-      "p 0.0s|     1 |     0 |     1 |     - | vbounds|   0 |  27 |  48 |  42 |   0 |  0 |   3 |   0 |-3.500000e+00 |-3.200000e+00 |   9.37%| unknown\n",
-      "  0.0s|     1 |     0 |    16 |     - |  1789k |   0 |  27 |  29 |  42 |   0 |  0 |   9 |   0 |-3.300000e+00 |-3.200000e+00 |   3.13%| unknown\n",
-      "  0.0s|     1 |     0 |    21 |     - |  1810k |   0 |  27 |  29 |  45 |   3 |  1 |   9 |   0 |-3.300000e+00 |-3.200000e+00 |   3.13%| unknown\n",
-      "r 0.0s|     1 |     0 |    21 |     - |rounding|   0 |  27 |  29 |  45 |   3 |  1 |   9 |   0 |-3.300000e+00 |-3.300000e+00 |   0.00%| unknown\n",
-      "  0.0s|     1 |     0 |    21 |     - |  1810k |   0 |  27 |  29 |  45 |   3 |  1 |   9 |   0 |-3.300000e+00 |-3.300000e+00 |   0.00%| unknown\n",
+      "p 0.0s|     1 |     0 |     0 |     - |  clique|   0 |  27 |  45 |  42 |   0 |  0 |   0 |   0 |-3.500000e+00 | 1.000000e-01 |    Inf | unknown\n",
+      "p 0.0s|     1 |     0 |     0 |     - |   locks|   0 |  27 |  45 |  42 |   0 |  0 |   0 |   0 |-3.500000e+00 |-6.000000e-01 | 483.33%| unknown\n",
+      "p 0.0s|     1 |     0 |     0 |     - | vbounds|   0 |  27 |  45 |  42 |   0 |  0 |   0 |   0 |-3.500000e+00 |-1.600000e+00 | 118.75%| unknown\n",
+      "p 0.0s|     1 |     0 |     0 |     - | vbounds|   0 |  27 |  46 |  42 |   0 |  0 |   1 |   0 |-3.500000e+00 |-3.200000e+00 |   9.37%| unknown\n",
+      "  0.0s|     1 |     0 |    14 |     - |  1786k |   0 |  27 |  29 |  42 |   0 |  0 |   7 |   0 |-3.300000e+00 |-3.200000e+00 |   3.13%| unknown\n",
+      "r 0.0s|     1 |     0 |    14 |     - |rounding|   0 |  27 |  29 |  42 |   0 |  0 |   7 |   0 |-3.300000e+00 |-3.300000e+00 |   0.00%| unknown\n",
+      "  0.0s|     1 |     0 |    14 |     - |  1786k |   0 |  27 |  29 |  42 |   0 |  0 |   7 |   0 |-3.300000e+00 |-3.300000e+00 |   0.00%| unknown\n",
       "\n",
       "SCIP Status        : problem is solved [optimal solution found]\n",
       "Solving Time (sec) : 0.00\n",
@@ -286,66 +283,68 @@
       "Primal Bound       : -3.30000000000000e+00 (5 solutions)\n",
       "Dual Bound         : -3.30000000000000e+00\n",
       "Gap                : 0.00 %\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Optimal value: 7.000e-01\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Compilation took 2.805e-02 seconds\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Solver (including time spent in interface) took 1.459e-02 seconds\n",
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : Finished in 0.07 s.\n"
+      "\n",
+      "(CVXPY) Apr 25 10:48:19 AM: Problem status: optimal\n",
+      "(CVXPY) Apr 25 10:48:19 AM: Optimal value: 7.000e-01\n",
+      "(CVXPY) Apr 25 10:48:19 AM: Compilation took 3.197e-02 seconds\n",
+      "(CVXPY) Apr 25 10:48:19 AM: Solver (including time spent in interface) took 1.419e-02 seconds\n",
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : Finished in 0.07 s.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : 2/2 outputs mapped to the graph\n"
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : 2/2 outputs mapped to the graph\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : Pruning the graph with size: V x E = (6, 6)...\n"
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : Pruning the graph with size: V x E = (6, 6)...\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : Finished. Final size: V x E = (6, 6).\n"
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : Finished. Final size: V x E = (6, 6).\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : 2/2 inputs after pruning.\n"
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : 2/2 inputs after pruning.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : 2/2 outputs after pruning.\n"
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : 2/2 outputs after pruning.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : Converting into a flow graph...\n"
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : Converting into a flow graph...\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : Creating a network flow problem...\n"
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : Creating a network flow problem...\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : Preprocess completed.\n"
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : Preprocess completed.\n"
      ]
     },
     {
@@ -356,35 +355,35 @@
       "                                     CVXPY                                     \n",
       "                                     v1.4.3                                    \n",
       "===============================================================================\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Your problem has 86 variables, 20 constraints, and 0 parameters.\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Your problem has 86 variables, 20 constraints, and 0 parameters.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: It is compliant with the following grammars: DCP, DQCP\n"
+      "(CVXPY) Apr 25 10:48:19 AM: It is compliant with the following grammars: DCP, DQCP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
+      "(CVXPY) Apr 25 10:48:19 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:48:19 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: Your problem is compiled with the CPP canonicalization backend.\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Your problem is compiled with the CPP canonicalization backend.\n"
      ]
     },
     {
@@ -394,49 +393,49 @@
       "-------------------------------------------------------------------------------\n",
       "                                  Compilation                                  \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Compiling problem (target solver=SCIP).\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Compiling problem (target solver=SCIP).\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIP\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Reduction chain: Dcp2Cone -> CvxAttr2Constr -> ConeMatrixStuffing -> SCIP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: Applying reduction Dcp2Cone\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Applying reduction Dcp2Cone\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: Applying reduction CvxAttr2Constr\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Applying reduction CvxAttr2Constr\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: Applying reduction ConeMatrixStuffing\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Applying reduction ConeMatrixStuffing\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: Applying reduction SCIP\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Applying reduction SCIP\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: Finished problem compilation (took 2.805e-02 seconds).\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Finished problem compilation (took 3.197e-02 seconds).\n"
      ]
     },
     {
@@ -446,7 +445,7 @@
       "-------------------------------------------------------------------------------\n",
       "                                Numerical solver                               \n",
       "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Invoking solver SCIP  to obtain a solution.\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Invoking solver SCIP  to obtain a solution.\n"
      ]
     },
     {
@@ -455,9 +454,7 @@
      "text": [
       "-------------------------------------------------------------------------------\n",
       "                                    Summary                                    \n",
-      "-------------------------------------------------------------------------------\n",
-      "(CVXPY) Apr 25 10:41:51 AM: Problem status: optimal\n",
-      "presolving:\n",
+      "-------------------------------------------------------------------------------presolving:\n",
       "(round 1, fast)       36 del vars, 95 del conss, 0 add conss, 48 chg bounds, 1 chg sides, 23 chg coeffs, 0 upgd conss, 0 impls, 28 clqs\n",
       "(round 2, fast)       54 del vars, 129 del conss, 0 add conss, 52 chg bounds, 9 chg sides, 31 chg coeffs, 0 upgd conss, 0 impls, 20 clqs\n",
       "(round 3, fast)       63 del vars, 145 del conss, 0 add conss, 52 chg bounds, 11 chg sides, 33 chg coeffs, 0 upgd conss, 0 impls, 18 clqs\n",
@@ -488,49 +485,50 @@
       "Presolving Time: 0.00\n",
       "\n",
       " time | node  | left  |LP iter|LP it/n|mem/heur|mdpt |vars |cons |rows |cuts |sepa|confs|strbr|  dualbound   | primalbound  |  gap   | compl. \n",
-      "p 0.0s|     1 |     0 |     1 |     - |  clique|   0 |  27 |  45 |  42 |   0 |  0 |   0 |   0 |-3.500000e+00 | 1.000000e-01 |    Inf | unknown\n",
-      "p 0.0s|     1 |     0 |     1 |     - |   locks|   0 |  27 |  45 |  42 |   0 |  0 |   0 |   0 |-3.500000e+00 |-6.000000e-01 | 483.33%| unknown\n",
-      "p 0.0s|     1 |     0 |     1 |     - | vbounds|   0 |  27 |  46 |  42 |   0 |  0 |   1 |   0 |-3.500000e+00 |-1.600000e+00 | 118.75%| unknown\n",
-      "p 0.0s|     1 |     0 |     1 |     - | vbounds|   0 |  27 |  48 |  42 |   0 |  0 |   3 |   0 |-3.500000e+00 |-3.200000e+00 |   9.37%| unknown\n",
-      "  0.0s|     1 |     0 |    16 |     - |  1789k |   0 |  27 |  29 |  42 |   0 |  0 |   9 |   0 |-3.300000e+00 |-3.200000e+00 |   3.13%| unknown\n",
-      "  0.0s|     1 |     0 |    21 |     - |  1810k |   0 |  27 |  29 |  45 |   3 |  1 |   9 |   0 |-3.300000e+00 |-3.200000e+00 |   3.13%| unknown\n",
-      "r 0.0s|     1 |     0 |    21 |     - |rounding|   0 |  27 |  29 |  45 |   3 |  1 |   9 |   0 |-3.300000e+00 |-3.300000e+00 |   0.00%| unknown\n",
-      "  0.0s|     1 |     0 |    21 |     - |  1810k |   0 |  27 |  29 |  45 |   3 |  1 |   9 |   0 |-3.300000e+00 |-3.300000e+00 |   0.00%| unknown\n",
+      "p 0.0s|     1 |     0 |     0 |     - |  clique|   0 |  27 |  45 |  42 |   0 |  0 |   0 |   0 |-3.500000e+00 | 1.000000e-01 |    Inf | unknown\n",
+      "p 0.0s|     1 |     0 |     0 |     - |   locks|   0 |  27 |  45 |  42 |   0 |  0 |   0 |   0 |-3.500000e+00 |-6.000000e-01 | 483.33%| unknown\n",
+      "p 0.0s|     1 |     0 |     0 |     - | vbounds|   0 |  27 |  45 |  42 |   0 |  0 |   0 |   0 |-3.500000e+00 |-1.600000e+00 | 118.75%| unknown\n",
+      "p 0.0s|     1 |     0 |     0 |     - | vbounds|   0 |  27 |  46 |  42 |   0 |  0 |   1 |   0 |-3.500000e+00 |-3.200000e+00 |   9.37%| unknown\n",
+      "  0.0s|     1 |     0 |    14 |     - |  1786k |   0 |  27 |  29 |  42 |   0 |  0 |   7 |   0 |-3.300000e+00 |-3.200000e+00 |   3.13%| unknown\n",
+      "r 0.0s|     1 |     0 |    14 |     - |rounding|   0 |  27 |  29 |  42 |   0 |  0 |   7 |   0 |-3.300000e+00 |-3.300000e+00 |   0.00%| unknown\n",
+      "  0.0s|     1 |     0 |    14 |     - |  1786k |   0 |  27 |  29 |  42 |   0 |  0 |   7 |   0 |-3.300000e+00 |-3.300000e+00 |   0.00%| unknown\n",
       "\n",
       "SCIP Status        : problem is solved [optimal solution found]\n",
       "Solving Time (sec) : 0.00\n",
       "Solving Nodes      : 1\n",
       "Primal Bound       : -3.30000000000000e+00 (5 solutions)\n",
       "Dual Bound         : -3.30000000000000e+00\n",
-      "Gap                : 0.00 %\n"
+      "Gap                : 0.00 %\n",
+      "\n",
+      "(CVXPY) Apr 25 10:48:19 AM: Problem status: optimal\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: Optimal value: 7.000e-01\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Optimal value: 7.000e-01\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: Compilation took 2.805e-02 seconds\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Compilation took 3.197e-02 seconds\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CVXPY) Apr 25 10:41:51 AM: Solver (including time spent in interface) took 1.459e-02 seconds\n"
+      "(CVXPY) Apr 25 10:48:19 AM: Solver (including time spent in interface) took 1.419e-02 seconds\n"
      ]
     },
     {
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "(CORNETO) Apr 25 10:41:51 AM - INFO    : Finished in 0.07 s.\n"
+      "(CORNETO) Apr 25 10:48:19 AM - INFO    : Finished in 0.07 s.\n"
      ]
     }
    ],
@@ -672,7 +670,7 @@
        "</svg>\n"
       ],
       "text/plain": [
-       "<graphviz.graphs.Digraph at 0x7f99e2fedbd0>"
+       "<graphviz.graphs.Digraph at 0x7f6ca6799a10>"
       ]
      },
      "execution_count": 5,
@@ -722,32 +720,32 @@
        "  <tbody>\n",
        "    <tr>\n",
        "      <th>0</th>\n",
-       "      <td>I2</td>\n",
+       "      <td>M2</td>\n",
        "      <td>1.0</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>1</th>\n",
-       "      <td>M1</td>\n",
+       "      <td>I1</td>\n",
        "      <td>1.0</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>2</th>\n",
-       "      <td>N1</td>\n",
-       "      <td>0.0</td>\n",
+       "      <td>N2</td>\n",
+       "      <td>-1.0</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>3</th>\n",
-       "      <td>N2</td>\n",
-       "      <td>-1.0</td>\n",
+       "      <td>N1</td>\n",
+       "      <td>0.0</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>4</th>\n",
-       "      <td>I1</td>\n",
+       "      <td>M1</td>\n",
        "      <td>1.0</td>\n",
        "    </tr>\n",
        "    <tr>\n",
        "      <th>5</th>\n",
-       "      <td>M2</td>\n",
+       "      <td>I2</td>\n",
        "      <td>1.0</td>\n",
        "    </tr>\n",
        "    <tr>\n",
@@ -776,12 +774,12 @@
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-       "0        I2    1.0\n",
-       "1        M1    1.0\n",
-       "2        N1    0.0\n",
-       "3        N2   -1.0\n",
-       "4        I1    1.0\n",
-       "5        M2    1.0\n",
+       "0        M2    1.0\n",
+       "1        I1    1.0\n",
+       "2        N2   -1.0\n",
+       "3        N1    0.0\n",
+       "4        M1    1.0\n",
+       "5        I2    1.0\n",
        "6        _s    1.0\n",
        "7  _pert_c0    1.0\n",
        "8  _meas_c0    0.0\n",
@@ -1076,7 +1074,7 @@
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      },
      "execution_count": 8,
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+<g id="node127" class="node">
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+<polygon fill="none" stroke="black" points="999.26,-1261.05 992.26,-1261.05 992.26,-1254.05 999.26,-1254.05 999.26,-1261.05"/>
+</g>
+<!-- nad_c&#45;&gt;e_60_center -->
+<g id="edge210" class="edge">
+<title>nad_c&#45;&gt;e_60_center</title>
+<path fill="none" stroke="black" d="M1083.11,-1194.66C1076.58,-1201.27 1068.3,-1209.19 1060.28,-1215.58 1038.54,-1232.89 1009.53,-1249.78 999.42,-1255.5"/>
+</g>
+<!-- e_63_center -->
+<g id="node130" class="node">
+<title>e_63_center</title>
+<polygon fill="none" stroke="black" points="951.08,-1225.42 944.08,-1225.42 944.08,-1218.42 951.08,-1218.42 951.08,-1225.42"/>
+</g>
+<!-- nad_c&#45;&gt;e_63_center -->
+<g id="edge225" class="edge">
+<title>nad_c&#45;&gt;e_63_center</title>
+<path fill="none" stroke="black" d="M1077.29,-1180.04C1067.99,-1179.77 1056.56,-1180.06 1046.51,-1182.08 1007.3,-1189.98 963.83,-1212.91 951.2,-1219.88"/>
+</g>
+<!-- e_64_center -->
+<g id="node131" class="node">
+<title>e_64_center</title>
+<polygon fill="none" stroke="black" points="1000.43,-1109.55 993.43,-1109.55 993.43,-1102.55 1000.43,-1102.55 1000.43,-1109.55"/>
+</g>
+<!-- nad_c&#45;&gt;e_64_center -->
+<g id="edge230" class="edge">
+<title>nad_c&#45;&gt;e_64_center</title>
+<path fill="none" stroke="black" d="M1081.1,-1170.25C1057.93,-1152.57 1013.94,-1119.02 1000.76,-1108.97"/>
+</g>
+<!-- e_67_center -->
+<g id="node134" class="node">
+<title>e_67_center</title>
+<polygon fill="none" stroke="black" points="1281.96,-1138.68 1274.96,-1138.68 1274.96,-1131.68 1281.96,-1131.68 1281.96,-1138.68"/>
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+<!-- nad_c&#45;&gt;e_67_center -->
+<g id="edge246" class="edge">
+<title>nad_c&#45;&gt;e_67_center</title>
+<path fill="none" stroke="black" d="M1113.2,-1176.93C1154.12,-1166.59 1254.07,-1141.34 1274.7,-1136.13"/>
+</g>
+<!-- nad_c&#45;&gt;e_70_center -->
+<g id="edge253" class="edge">
+<title>nad_c&#45;&gt;e_70_center</title>
+<path fill="none" stroke="black" d="M1079.71,-1172.19C1058.52,-1159.75 1020.28,-1136.37 990.23,-1112.75 979.48,-1104.31 968.08,-1092.85 962.52,-1087.07"/>
+</g>
+<!-- accoa_c -->
+<g id="node4" class="node">
+<title>accoa_c</title>
+<ellipse fill="none" stroke="black" cx="810.37" cy="-1159.91" rx="18" ry="18"/>
+<text text-anchor="middle" x="810.37" y="-1156.21" font-family="Times,serif" font-size="14.00">accoa_c</text>
+</g>
+<!-- accoa_c&#45;&gt;e_12_center -->
+<g id="edge63" class="edge">
+<title>accoa_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M820.18,-1144.72C848.98,-1100.14 932.17,-971.36 947.51,-947.61"/>
+</g>
+<!-- e_14_center -->
+<g id="node51" class="node">
+<title>e_14_center</title>
+<polygon fill="none" stroke="black" points="664.47,-1222.08 657.47,-1222.08 657.47,-1215.08 664.47,-1215.08 664.47,-1222.08"/>
+</g>
+<!-- accoa_c&#45;&gt;e_14_center -->
+<g id="edge75" class="edge">
+<title>accoa_c&#45;&gt;e_14_center</title>
+<path fill="none" stroke="black" d="M793.52,-1166.53C759.03,-1180.07 682.13,-1210.27 664.59,-1217.16"/>
+</g>
+<!-- e_61_center -->
+<g id="node128" class="node">
+<title>e_61_center</title>
+<polygon fill="none" stroke="black" points="754.54,-1348.04 747.54,-1348.04 747.54,-1341.04 754.54,-1341.04 754.54,-1348.04"/>
+</g>
+<!-- accoa_c&#45;&gt;e_61_center -->
+<g id="edge214" class="edge">
+<title>accoa_c&#45;&gt;e_61_center</title>
+<path fill="none" stroke="black" d="M807.24,-1177.9C803.81,-1196.4 797.73,-1225.93 789.86,-1250.73 778.45,-1286.69 758.99,-1328.08 752.91,-1340.7"/>
+</g>
+<!-- e_81_center -->
+<g id="node144" class="node">
+<title>e_81_center</title>
+<polygon fill="none" stroke="black" points="595.3,-1133.39 588.3,-1133.39 588.3,-1126.39 595.3,-1126.39 595.3,-1133.39"/>
+</g>
+<!-- accoa_c&#45;&gt;e_81_center -->
+<g id="edge298" class="edge">
+<title>accoa_c&#45;&gt;e_81_center</title>
+<path fill="none" stroke="black" d="M792.1,-1158.48C775.18,-1157.08 749.32,-1154.72 726.96,-1151.83 674.62,-1145.05 611.41,-1133.53 595.55,-1130.59"/>
+</g>
+<!-- nadh_c -->
+<g id="node5" class="node">
+<title>nadh_c</title>
+<ellipse fill="none" stroke="black" cx="1046.46" cy="-1201.68" rx="18" ry="18"/>
+<text text-anchor="middle" x="1046.46" y="-1197.98" font-family="Times,serif" font-size="14.00">nadh_c</text>
+</g>
+<!-- e_66_center -->
+<g id="node133" class="node">
+<title>e_66_center</title>
+<polygon fill="none" stroke="black" points="969.17,-1479.02 962.17,-1479.02 962.17,-1472.02 969.17,-1472.02 969.17,-1479.02"/>
+</g>
+<!-- nadh_c&#45;&gt;e_66_center -->
+<g id="edge240" class="edge">
+<title>nadh_c&#45;&gt;e_66_center</title>
+<path fill="none" stroke="black" d="M1041.28,-1219.22C1024.91,-1274.71 974.88,-1444.3 966.78,-1471.75"/>
+</g>
+<!-- e_91_center -->
+<g id="node154" class="node">
+<title>e_91_center</title>
+<polygon fill="none" stroke="black" points="1119.77,-1275.95 1112.77,-1275.95 1112.77,-1268.95 1119.77,-1268.95 1119.77,-1275.95"/>
+</g>
+<!-- nadh_c&#45;&gt;e_91_center -->
+<g id="edge336" class="edge">
+<title>nadh_c&#45;&gt;e_91_center</title>
+<path fill="none" stroke="black" d="M1059.26,-1214.66C1075.64,-1231.26 1103.04,-1259.03 1112.73,-1268.87"/>
+</g>
+<!-- h_c -->
+<g id="node6" class="node">
+<title>h_c</title>
+<ellipse fill="none" stroke="black" cx="911.41" cy="-1310.11" rx="18" ry="18"/>
+<text text-anchor="middle" x="911.41" y="-1306.41" font-family="Times,serif" font-size="14.00">h_c</text>
+</g>
+<!-- e_15_center -->
+<g id="node55" class="node">
+<title>e_15_center</title>
+<polygon fill="none" stroke="black" points="740.69,-1560.2 733.69,-1560.2 733.69,-1553.2 740.69,-1553.2 740.69,-1560.2"/>
+</g>
+<!-- h_c&#45;&gt;e_15_center -->
+<g id="edge83" class="edge">
+<title>h_c&#45;&gt;e_15_center</title>
+<path fill="none" stroke="black" d="M899.89,-1324.51C878.68,-1351.19 832.36,-1410.34 796.42,-1462.44 772.72,-1496.8 746.85,-1540.28 739.34,-1553.03"/>
+</g>
+<!-- e_54_center -->
+<g id="node119" class="node">
+<title>e_54_center</title>
+<polygon fill="none" stroke="black" points="1093.53,-1117 1086.53,-1117 1086.53,-1110 1093.53,-1110 1093.53,-1117"/>
+</g>
+<!-- h_c&#45;&gt;e_54_center -->
+<g id="edge185" class="edge">
+<title>h_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" d="M923.69,-1296.6C960.1,-1256.52 1066.24,-1139.68 1086.62,-1117.25"/>
+</g>
+<!-- h_c&#45;&gt;e_66_center -->
+<g id="edge241" class="edge">
+<title>h_c&#45;&gt;e_66_center</title>
+<path fill="none" stroke="black" d="M913.63,-1328.02C915.97,-1344.85 920.22,-1370.64 926.62,-1392.38 928.5,-1398.77 929.61,-1400.16 932.32,-1406.25 943.63,-1431.61 958.58,-1461.49 963.78,-1471.8"/>
+</g>
+<!-- e_82_center -->
+<g id="node145" class="node">
+<title>e_82_center</title>
+<polygon fill="none" stroke="black" points="780.91,-1045.84 773.91,-1045.84 773.91,-1038.84 780.91,-1038.84 780.91,-1045.84"/>
+</g>
+<!-- h_c&#45;&gt;e_82_center -->
+<g id="edge303" class="edge">
+<title>h_c&#45;&gt;e_82_center</title>
+<path fill="none" stroke="black" d="M905.12,-1292.95C897.72,-1272.85 884.98,-1238.6 873.52,-1209.37 871.08,-1203.17 870.81,-1201.46 867.85,-1195.49 837.11,-1133.53 790.92,-1062.75 779.86,-1046.02"/>
+</g>
+<!-- e_0_center&#45;&gt;accoa_c -->
+<g id="edge4" class="edge">
+<title>e_0_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="black" d="M1102.89,-1303.69C1089.9,-1296.01 1043.15,-1268.84 1002.46,-1250.85 975.85,-1239.08 967.5,-1240.37 940.88,-1228.62 902.9,-1211.87 860.69,-1188.78 834.84,-1174.1"/>
+<polygon fill="black" stroke="black" points="836.51,-1171.03 826.09,-1169.1 833.03,-1177.1 836.51,-1171.03"/>
+</g>
+<!-- e_0_center&#45;&gt;nadh_c -->
+<g id="edge5" class="edge">
+<title>e_0_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" d="M1104.11,-1301.81C1097.06,-1289.58 1075.21,-1251.61 1060.52,-1226.1"/>
+<polygon fill="black" stroke="black" points="1063.5,-1224.26 1055.48,-1217.34 1057.43,-1227.75 1063.5,-1224.26"/>
+</g>
+<!-- e_0_center&#45;&gt;h_c -->
+<g id="edge6" class="edge">
+<title>e_0_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1102.67,-1305.85C1082.74,-1306.29 987.81,-1308.41 939.62,-1309.49"/>
+<polygon fill="black" stroke="black" points="939.46,-1305.99 929.54,-1309.71 939.62,-1312.99 939.46,-1305.99"/>
+</g>
+<!-- acald_e -->
+<g id="node8" class="node">
+<title>acald_e</title>
+<ellipse fill="none" stroke="black" cx="1845.44" cy="-1428.03" rx="18" ry="18"/>
+<text text-anchor="middle" x="1845.44" y="-1424.33" font-family="Times,serif" font-size="14.00">acald_e</text>
+</g>
+<!-- acald_e&#45;&gt;acald_c -->
+<g id="edge7" class="edge">
+<title>acald_e&#45;&gt;acald_c</title>
+<path fill="none" stroke="black" d="M1827.54,-1425.55C1766.43,-1417.06 1565.72,-1389.18 1491.58,-1378.88"/>
+<polygon fill="black" stroke="black" points="1491.98,-1375.41 1481.59,-1377.5 1491.01,-1382.34 1491.98,-1375.41"/>
+</g>
+<!-- e_20_target -->
+<g id="node64" class="node">
+<title>e_20_target</title>
+<ellipse fill="black" stroke="black" cx="2089.18" cy="-1466.88" rx="1.8" ry="1.8"/>
+</g>
+<!-- acald_e&#45;&gt;e_20_target -->
+<g id="edge99" class="edge">
+<title>acald_e&#45;&gt;e_20_target</title>
+<path fill="none" stroke="black" d="M1863.36,-1430.89C1910.67,-1438.43 2037.97,-1458.72 2077.38,-1465"/>
+<polygon fill="black" stroke="black" points="2076.84,-1468.45 2087.26,-1466.57 2077.94,-1461.54 2076.84,-1468.45"/>
+</g>
+<!-- atp_c -->
+<g id="node9" class="node">
+<title>atp_c</title>
+<ellipse fill="none" stroke="black" cx="722.32" cy="-1049.99" rx="18" ry="18"/>
+<text text-anchor="middle" x="722.32" y="-1046.29" font-family="Times,serif" font-size="14.00">atp_c</text>
+</g>
+<!-- e_2_center -->
+<g id="node13" class="node">
+<title>e_2_center</title>
+<polygon fill="none" stroke="black" points="489.88,-1132.95 482.88,-1132.95 482.88,-1125.95 489.88,-1125.95 489.88,-1132.95"/>
+</g>
+<!-- atp_c&#45;&gt;e_2_center -->
+<g id="edge8" class="edge">
+<title>atp_c&#45;&gt;e_2_center</title>
+<path fill="none" stroke="black" d="M704.97,-1055.83C655.37,-1072.53 514.98,-1119.81 490.15,-1128.18"/>
+</g>
+<!-- e_6_center -->
+<g id="node24" class="node">
+<title>e_6_center</title>
+<polygon fill="none" stroke="black" points="528.76,-914.56 521.76,-914.56 521.76,-907.56 528.76,-907.56 528.76,-914.56"/>
+</g>
+<!-- atp_c&#45;&gt;e_6_center -->
+<g id="edge22" class="edge">
+<title>atp_c&#45;&gt;e_6_center</title>
+<path fill="none" stroke="black" d="M707.5,-1039.54C666.15,-1010.39 551.04,-929.23 528.96,-913.66"/>
+</g>
+<!-- e_10_center -->
+<g id="node34" class="node">
+<title>e_10_center</title>
+<polygon fill="none" stroke="black" points="711.89,-1184.23 704.89,-1184.23 704.89,-1177.23 711.89,-1177.23 711.89,-1184.23"/>
+</g>
+<!-- atp_c&#45;&gt;e_10_center -->
+<g id="edge40" class="edge">
+<title>atp_c&#45;&gt;e_10_center</title>
+<path fill="none" stroke="black" d="M718.08,-1067.5C714.32,-1084.05 709.17,-1109.65 707.37,-1132.21 706.04,-1149.01 707.41,-1169.18 708.08,-1177.2"/>
+</g>
+<!-- atp_c&#45;&gt;e_12_center -->
+<g id="edge62" class="edge">
+<title>atp_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M739.54,-1044.64C770.58,-1034.68 837.55,-1011.79 890.07,-983.87 912.6,-971.89 937.25,-953.57 946.34,-946.62"/>
+</g>
+<!-- e_50_center -->
+<g id="node115" class="node">
+<title>e_50_center</title>
+<polygon fill="none" stroke="black" points="962.14,-1043.72 955.14,-1043.72 955.14,-1036.72 962.14,-1036.72 962.14,-1043.72"/>
+</g>
+<!-- atp_c&#45;&gt;e_50_center -->
+<g id="edge160" class="edge">
+<title>atp_c&#45;&gt;e_50_center</title>
+<path fill="none" stroke="black" d="M740.46,-1050.25C752.78,-1050.3 769.45,-1050.1 784.11,-1049.04 804.61,-1047.56 809.48,-1044.65 829.97,-1043.1 879.43,-1039.35 939.87,-1039.94 955.05,-1040.16"/>
+</g>
+<!-- e_51_center -->
+<g id="node116" class="node">
+<title>e_51_center</title>
+<polygon fill="none" stroke="black" points="627.63,-1045.2 620.63,-1045.2 620.63,-1038.2 627.63,-1038.2 627.63,-1045.2"/>
+</g>
+<!-- atp_c&#45;&gt;e_51_center -->
+<g id="edge167" class="edge">
+<title>atp_c&#45;&gt;e_51_center</title>
+<path fill="none" stroke="black" d="M704.31,-1048.47C680.39,-1046.45 639.75,-1043.02 627.64,-1042"/>
+</g>
+<!-- e_71_center -->
+<g id="node136" class="node">
+<title>e_71_center</title>
+<polygon fill="none" stroke="black" points="842.37,-904.95 835.37,-904.95 835.37,-897.95 842.37,-897.95 842.37,-904.95"/>
+</g>
+<!-- atp_c&#45;&gt;e_71_center -->
+<g id="edge257" class="edge">
+<title>atp_c&#45;&gt;e_71_center</title>
+<path fill="none" stroke="black" d="M731.83,-1034.33C742.73,-1016.77 761.49,-987.7 780.02,-964.44 799.22,-940.32 825.63,-914.23 835.21,-904.96"/>
+</g>
+<!-- e_74_center -->
+<g id="node138" class="node">
+<title>e_74_center</title>
+<polygon fill="none" stroke="black" points="668.33,-810.83 661.33,-810.83 661.33,-803.83 668.33,-803.83 668.33,-810.83"/>
+</g>
+<!-- atp_c&#45;&gt;e_74_center -->
+<g id="edge268" class="edge">
+<title>atp_c&#45;&gt;e_74_center</title>
+<path fill="none" stroke="black" d="M711.7,-1035.26C706.39,-1027.04 700.48,-1016.37 697.5,-1005.89 675.67,-928.93 666.75,-830.77 665.11,-810.93"/>
+</g>
+<!-- e_79_center -->
+<g id="node142" class="node">
+<title>e_79_center</title>
+<polygon fill="none" stroke="black" points="875.97,-895.95 868.97,-895.95 868.97,-888.95 875.97,-888.95 875.97,-895.95"/>
+</g>
+<!-- atp_c&#45;&gt;e_79_center -->
+<g id="edge286" class="edge">
+<title>atp_c&#45;&gt;e_79_center</title>
+<path fill="none" stroke="black" d="M730.98,-1034.08C741.26,-1016.05 759.6,-986.3 780.02,-964.44 810.29,-932.03 856.05,-902.61 868.96,-894.6"/>
+</g>
+<!-- e_80_center -->
+<g id="node143" class="node">
+<title>e_80_center</title>
+<polygon fill="none" stroke="black" points="668.01,-1026.38 661.01,-1026.38 661.01,-1019.38 668.01,-1019.38 668.01,-1026.38"/>
+</g>
+<!-- atp_c&#45;&gt;e_80_center -->
+<g id="edge291" class="edge">
+<title>atp_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="black" d="M705.91,-1042.29C692.82,-1036.16 675.51,-1028.04 668.11,-1024.57"/>
+</g>
+<!-- atp_c&#45;&gt;e_89_center -->
+<g id="edge325" class="edge">
+<title>atp_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="black" d="M728.97,-1066.98C735,-1083.39 743.41,-1109.08 746.57,-1132.24 755.5,-1197.65 746.65,-1278.68 744.45,-1296.77"/>
+</g>
+<!-- ac_c -->
+<g id="node10" class="node">
+<title>ac_c</title>
+<ellipse fill="none" stroke="black" cx="421.51" cy="-1397.64" rx="18" ry="18"/>
+<text text-anchor="middle" x="421.51" y="-1393.94" font-family="Times,serif" font-size="14.00">ac_c</text>
+</g>
+<!-- ac_c&#45;&gt;e_2_center -->
+<g id="edge9" class="edge">
+<title>ac_c&#45;&gt;e_2_center</title>
+<path fill="none" stroke="black" d="M425.77,-1380.05C439.02,-1325.27 479.02,-1159.89 485.49,-1133.12"/>
+</g>
+<!-- actp_c -->
+<g id="node11" class="node">
+<title>actp_c</title>
+<ellipse fill="none" stroke="black" cx="325.97" cy="-1083.54" rx="18" ry="18"/>
+<text text-anchor="middle" x="325.97" y="-1079.84" font-family="Times,serif" font-size="14.00">actp_c</text>
+</g>
+<!-- adp_c -->
+<g id="node12" class="node">
+<title>adp_c</title>
+<ellipse fill="none" stroke="black" cx="717.1" cy="-1005.95" rx="18" ry="18"/>
+<text text-anchor="middle" x="717.1" y="-1002.25" font-family="Times,serif" font-size="14.00">adp_c</text>
+</g>
+<!-- e_11_center -->
+<g id="node35" class="node">
+<title>e_11_center</title>
+<polygon fill="none" stroke="black" points="786.66,-1247.53 779.66,-1247.53 779.66,-1240.53 786.66,-1240.53 786.66,-1247.53"/>
+</g>
+<!-- adp_c&#45;&gt;e_11_center -->
+<g id="edge47" class="edge">
+<title>adp_c&#45;&gt;e_11_center</title>
+<path fill="none" stroke="black" d="M727.54,-1020.75C732.79,-1029 738.71,-1039.69 741.92,-1050.11 747.83,-1069.36 777.39,-1215.44 782.43,-1240.41"/>
+</g>
+<!-- adp_c&#45;&gt;e_82_center -->
+<g id="edge304" class="edge">
+<title>adp_c&#45;&gt;e_82_center</title>
+<path fill="none" stroke="black" d="M732.63,-1015.32C746.32,-1023.58 765.3,-1035.03 773.44,-1039.95"/>
+</g>
+<!-- e_2_center&#45;&gt;actp_c -->
+<g id="edge10" class="edge">
+<title>e_2_center&#45;&gt;actp_c</title>
+<path fill="none" stroke="black" d="M482.73,-1128.4C465.69,-1123.53 393.2,-1102.78 353.04,-1091.29"/>
+<polygon fill="black" stroke="black" points="353.92,-1087.9 343.34,-1088.52 351.99,-1094.63 353.92,-1087.9"/>
+</g>
+<!-- e_2_center&#45;&gt;adp_c -->
+<g id="edge11" class="edge">
+<title>e_2_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" d="M490,-1127.51C512.88,-1115.26 638.04,-1048.27 692.16,-1019.3"/>
+<polygon fill="black" stroke="black" points="693.94,-1022.32 701.1,-1014.51 690.63,-1016.15 693.94,-1022.32"/>
+</g>
+<!-- cit_c -->
+<g id="node14" class="node">
+<title>cit_c</title>
+<ellipse fill="none" stroke="black" cx="368.41" cy="-1238.7" rx="18" ry="18"/>
+<text text-anchor="middle" x="368.41" y="-1235" font-family="Times,serif" font-size="14.00">cit_c</text>
+</g>
+<!-- e_3_center -->
+<g id="node17" class="node">
+<title>e_3_center</title>
+<polygon fill="none" stroke="black" points="393.82,-1145.99 386.82,-1145.99 386.82,-1138.99 393.82,-1138.99 393.82,-1145.99"/>
+</g>
+<!-- cit_c&#45;&gt;e_3_center -->
+<g id="edge12" class="edge">
+<title>cit_c&#45;&gt;e_3_center</title>
+<path fill="none" stroke="black" d="M372.43,-1221.05C377.72,-1197.83 386.67,-1158.53 389.46,-1146.26"/>
+</g>
+<!-- acon_C_c -->
+<g id="node15" class="node">
+<title>acon_C_c</title>
+<ellipse fill="none" stroke="black" cx="208.35" cy="-1202.14" rx="18" ry="18"/>
+<text text-anchor="middle" x="208.35" y="-1198.44" font-family="Times,serif" font-size="14.00">acon_C_c</text>
+</g>
+<!-- e_4_center -->
+<g id="node19" class="node">
+<title>e_4_center</title>
+<polygon fill="none" stroke="black" points="453.87,-1244.9 446.87,-1244.9 446.87,-1237.9 453.87,-1237.9 453.87,-1244.9"/>
+</g>
+<!-- acon_C_c&#45;&gt;e_4_center -->
+<g id="edge15" class="edge">
+<title>acon_C_c&#45;&gt;e_4_center</title>
+<path fill="none" stroke="black" d="M226.74,-1203.12C256.67,-1204.94 317.69,-1209.54 368.53,-1219.1 399.21,-1224.87 435.2,-1236.38 446.67,-1240.16"/>
+</g>
+<!-- h2o_c -->
+<g id="node16" class="node">
+<title>h2o_c</title>
+<ellipse fill="none" stroke="black" cx="726.97" cy="-1132.23" rx="18" ry="18"/>
+<text text-anchor="middle" x="726.97" y="-1128.53" font-family="Times,serif" font-size="14.00">h2o_c</text>
+</g>
+<!-- h2o_c&#45;&gt;e_4_center -->
+<g id="edge16" class="edge">
+<title>h2o_c&#45;&gt;e_4_center</title>
+<path fill="none" stroke="black" d="M710.08,-1138.89C654.96,-1160.65 482.19,-1228.84 454.21,-1239.89"/>
+</g>
+<!-- h2o_c&#45;&gt;e_10_center -->
+<g id="edge41" class="edge">
+<title>h2o_c&#45;&gt;e_10_center</title>
+<path fill="none" stroke="black" d="M720.47,-1149.19C716.62,-1159.25 712.07,-1171.14 709.81,-1177.04"/>
+</g>
+<!-- h2o_c&#45;&gt;e_12_center -->
+<g id="edge58" class="edge">
+<title>h2o_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M737.77,-1117.34C744.05,-1109.12 752.35,-1098.95 760.71,-1090.78 828.84,-1024.2 926.52,-959.14 946.36,-946.16"/>
+</g>
+<!-- h2o_c&#45;&gt;e_14_center -->
+<g id="edge76" class="edge">
+<title>h2o_c&#45;&gt;e_14_center</title>
+<path fill="none" stroke="black" d="M715.78,-1146.87C700.18,-1167.28 672.83,-1203.06 663.89,-1214.76"/>
+</g>
+<!-- e_40_center -->
+<g id="node99" class="node">
+<title>e_40_center</title>
+<polygon fill="none" stroke="black" points="793.71,-837.53 786.71,-837.53 786.71,-830.53 793.71,-830.53 793.71,-837.53"/>
+</g>
+<!-- h2o_c&#45;&gt;e_40_center -->
+<g id="edge121" class="edge">
+<title>h2o_c&#45;&gt;e_40_center</title>
+<path fill="none" stroke="black" d="M730.74,-1114.46C743.29,-1055.28 783.24,-866.89 789.41,-837.81"/>
+</g>
+<!-- e_45_center -->
+<g id="node107" class="node">
+<title>e_45_center</title>
+<polygon fill="none" stroke="black" points="806.62,-1472.64 799.62,-1472.64 799.62,-1465.64 806.62,-1465.64 806.62,-1472.64"/>
+</g>
+<!-- h2o_c&#45;&gt;e_45_center -->
+<g id="edge138" class="edge">
+<title>h2o_c&#45;&gt;e_45_center</title>
+<path fill="none" stroke="black" d="M730.96,-1149.86C745.53,-1214.31 795.38,-1434.88 802.32,-1465.58"/>
+</g>
+<!-- h2o_c&#45;&gt;e_51_center -->
+<g id="edge169" class="edge">
+<title>h2o_c&#45;&gt;e_51_center</title>
+<path fill="none" stroke="black" d="M713.1,-1120.02C689.2,-1098.98 641.48,-1056.98 627.85,-1044.98"/>
+</g>
+<!-- e_52_center -->
+<g id="node117" class="node">
+<title>e_52_center</title>
+<polygon fill="none" stroke="black" points="1058.43,-1101.64 1051.43,-1101.64 1051.43,-1094.64 1058.43,-1094.64 1058.43,-1101.64"/>
+</g>
+<!-- h2o_c&#45;&gt;e_52_center -->
+<g id="edge175" class="edge">
+<title>h2o_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="black" d="M744.78,-1129.34C787.17,-1122.63 897.43,-1106 990.23,-1099.35 1013.54,-1097.68 1041.68,-1097.92 1051.42,-1098.07"/>
+</g>
+<!-- e_53_center -->
+<g id="node118" class="node">
+<title>e_53_center</title>
+<polygon fill="none" stroke="black" points="1025.69,-977.67 1018.69,-977.67 1018.69,-970.67 1025.69,-970.67 1025.69,-977.67"/>
+</g>
+<!-- h2o_c&#45;&gt;e_53_center -->
+<g id="edge181" class="edge">
+<title>h2o_c&#45;&gt;e_53_center</title>
+<path fill="none" stroke="black" d="M745.25,-1130.14C754.18,-1128.88 765.03,-1126.97 774.53,-1124.26 780.94,-1122.42 782.46,-1121.57 788.39,-1118.53 886.1,-1068.62 996.96,-991.87 1018.47,-976.79"/>
+</g>
+<!-- h2o_c&#45;&gt;e_61_center -->
+<g id="edge215" class="edge">
+<title>h2o_c&#45;&gt;e_61_center</title>
+<path fill="none" stroke="black" d="M730.42,-1150.06C735.97,-1179.74 746.66,-1241.2 750.68,-1293.77 752.03,-1311.35 751.49,-1332.45 751.19,-1340.84"/>
+</g>
+<!-- e_75_center -->
+<g id="node139" class="node">
+<title>e_75_center</title>
+<polygon fill="none" stroke="black" points="1082.37,-1040.83 1075.37,-1040.83 1075.37,-1033.83 1082.37,-1033.83 1082.37,-1040.83"/>
+</g>
+<!-- h2o_c&#45;&gt;e_75_center -->
+<g id="edge272" class="edge">
+<title>h2o_c&#45;&gt;e_75_center</title>
+<path fill="none" stroke="black" d="M745.13,-1129.67C754.03,-1128.3 764.89,-1126.43 774.53,-1124.26 838.04,-1109.91 1044.8,-1047.62 1075.14,-1038.45"/>
+</g>
+<!-- e_78_center -->
+<g id="node141" class="node">
+<title>e_78_center</title>
+<polygon fill="none" stroke="black" points="885.39,-1033.68 878.39,-1033.68 878.39,-1026.68 885.39,-1026.68 885.39,-1033.68"/>
+</g>
+<!-- h2o_c&#45;&gt;e_78_center -->
+<g id="edge282" class="edge">
+<title>h2o_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="black" d="M737.73,-1117.3C744,-1109.07 752.31,-1098.91 760.71,-1090.78 782.92,-1069.31 789.23,-1064.03 816.08,-1048.74 837.74,-1036.41 868.15,-1031.82 878.38,-1030.57"/>
+</g>
+<!-- h2o_c&#45;&gt;e_80_center -->
+<g id="edge293" class="edge">
+<title>h2o_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="black" d="M718.02,-1116.56C703.32,-1090.81 674.85,-1040.99 666.73,-1026.76"/>
+</g>
+<!-- e_3_center&#45;&gt;acon_C_c -->
+<g id="edge13" class="edge">
+<title>e_3_center&#45;&gt;acon_C_c</title>
+<path fill="none" stroke="black" d="M386.52,-1143.73C367.34,-1150.02 280.36,-1178.53 235.42,-1193.26"/>
+<polygon fill="black" stroke="black" points="234.14,-1190 225.73,-1196.44 236.32,-1196.65 234.14,-1190"/>
+</g>
+<!-- e_3_center&#45;&gt;h2o_c -->
+<g id="edge14" class="edge">
+<title>e_3_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="black" d="M394.02,-1142.39C414.46,-1141.86 515.74,-1139.17 598.5,-1136.59 632.85,-1135.52 672.36,-1134.16 698.4,-1133.24"/>
+<polygon fill="black" stroke="black" points="698.81,-1136.73 708.68,-1132.88 698.56,-1129.74 698.81,-1136.73"/>
+</g>
+<!-- icit_c -->
+<g id="node18" class="node">
+<title>icit_c</title>
+<ellipse fill="none" stroke="black" cx="668.2" cy="-1365.43" rx="18" ry="18"/>
+<text text-anchor="middle" x="668.2" y="-1361.73" font-family="Times,serif" font-size="14.00">icit_c</text>
+</g>
+<!-- e_58_center -->
+<g id="node124" class="node">
+<title>e_58_center</title>
+<polygon fill="none" stroke="black" points="1001.97,-1169.74 994.97,-1169.74 994.97,-1162.74 1001.97,-1162.74 1001.97,-1169.74"/>
+</g>
+<!-- icit_c&#45;&gt;e_58_center -->
+<g id="edge202" class="edge">
+<title>icit_c&#45;&gt;e_58_center</title>
+<path fill="none" stroke="black" d="M683.69,-1356.09C744.39,-1319.48 964.29,-1186.85 994.92,-1168.38"/>
+</g>
+<!-- e_59_center -->
+<g id="node126" class="node">
+<title>e_59_center</title>
+<polygon fill="none" stroke="black" points="543.05,-1617.62 536.05,-1617.62 536.05,-1610.62 543.05,-1610.62 543.05,-1617.62"/>
+</g>
+<!-- icit_c&#45;&gt;e_59_center -->
+<g id="edge206" class="edge">
+<title>icit_c&#45;&gt;e_59_center</title>
+<path fill="none" stroke="black" d="M659.76,-1381.75C633.6,-1432.32 554.83,-1584.59 541.48,-1610.38"/>
+</g>
+<!-- e_4_center&#45;&gt;icit_c -->
+<g id="edge17" class="edge">
+<title>e_4_center&#45;&gt;icit_c</title>
+<path fill="none" stroke="black" d="M454.15,-1243.56C476.49,-1256.27 591.98,-1322.03 643.43,-1351.33"/>
+<polygon fill="black" stroke="black" points="641.83,-1354.44 652.25,-1356.35 645.29,-1348.36 641.83,-1354.44"/>
+</g>
+<!-- ac_e -->
+<g id="node20" class="node">
+<title>ac_e</title>
+<ellipse fill="none" stroke="black" cx="406.26" cy="-1866.13" rx="18" ry="18"/>
+<text text-anchor="middle" x="406.26" y="-1862.43" font-family="Times,serif" font-size="14.00">ac_e</text>
+</g>
+<!-- e_5_center -->
+<g id="node22" class="node">
+<title>e_5_center</title>
+<polygon fill="none" stroke="black" points="641.65,-1579.97 634.65,-1579.97 634.65,-1572.97 641.65,-1572.97 641.65,-1579.97"/>
+</g>
+<!-- ac_e&#45;&gt;e_5_center -->
+<g id="edge18" class="edge">
+<title>ac_e&#45;&gt;e_5_center</title>
+<path fill="none" stroke="black" d="M417.76,-1851.77C460.9,-1797.89 611.8,-1609.39 635.11,-1580.26"/>
+</g>
+<!-- e_19_target -->
+<g id="node63" class="node">
+<title>e_19_target</title>
+<ellipse fill="black" stroke="black" cx="236.03" cy="-2074.13" rx="1.8" ry="1.8"/>
+</g>
+<!-- ac_e&#45;&gt;e_19_target -->
+<g id="edge98" class="edge">
+<title>ac_e&#45;&gt;e_19_target</title>
+<path fill="none" stroke="black" d="M394.83,-1880.1C362.54,-1919.55 271.24,-2031.11 243.88,-2064.55"/>
+<polygon fill="black" stroke="black" points="241.02,-2062.51 237.4,-2072.47 246.44,-2066.95 241.02,-2062.51"/>
+</g>
+<!-- h_e -->
+<g id="node21" class="node">
+<title>h_e</title>
+<ellipse fill="none" stroke="black" cx="917.98" cy="-1515.32" rx="18" ry="18"/>
+<text text-anchor="middle" x="917.98" y="-1511.62" font-family="Times,serif" font-size="14.00">h_e</text>
+</g>
+<!-- h_e&#45;&gt;e_5_center -->
+<g id="edge19" class="edge">
+<title>h_e&#45;&gt;e_5_center</title>
+<path fill="none" stroke="black" d="M900.03,-1518.05C866.5,-1523.28 792.2,-1535.48 730.49,-1550 695.75,-1558.17 654.56,-1571.18 641.98,-1575.23"/>
+</g>
+<!-- e_8_center -->
+<g id="node30" class="node">
+<title>e_8_center</title>
+<polygon fill="none" stroke="black" points="1208.84,-1472.44 1201.84,-1472.44 1201.84,-1465.44 1208.84,-1465.44 1208.84,-1472.44"/>
+</g>
+<!-- h_e&#45;&gt;e_8_center -->
+<g id="edge32" class="edge">
+<title>h_e&#45;&gt;e_8_center</title>
+<path fill="none" stroke="black" d="M935.45,-1510.95C974.15,-1501.5 1070.18,-1479.27 1152.03,-1470.37 1170.62,-1468.35 1193.06,-1468.63 1201.7,-1468.84"/>
+</g>
+<!-- h_e&#45;&gt;e_11_center -->
+<g id="edge46" class="edge">
+<title>h_e&#45;&gt;e_11_center</title>
+<path fill="none" stroke="black" d="M909.95,-1499.17C883.31,-1445.55 798.73,-1275.38 785.04,-1247.82"/>
+</g>
+<!-- e_16_center -->
+<g id="node58" class="node">
+<title>e_16_center</title>
+<polygon fill="none" stroke="black" points="1128.72,-1639.08 1121.72,-1639.08 1121.72,-1632.08 1128.72,-1632.08 1128.72,-1639.08"/>
+</g>
+<!-- h_e&#45;&gt;e_16_center -->
+<g id="edge88" class="edge">
+<title>h_e&#45;&gt;e_16_center</title>
+<path fill="none" stroke="black" d="M933.56,-1524.36C977.24,-1549.71 1099.16,-1620.46 1121.63,-1633.5"/>
+</g>
+<!-- e_18_center -->
+<g id="node62" class="node">
+<title>e_18_center</title>
+<polygon fill="none" stroke="black" points="1079.89,-1678.71 1072.89,-1678.71 1072.89,-1671.71 1079.89,-1671.71 1079.89,-1678.71"/>
+</g>
+<!-- h_e&#45;&gt;e_18_center -->
+<g id="edge94" class="edge">
+<title>h_e&#45;&gt;e_18_center</title>
+<path fill="none" stroke="black" d="M930.68,-1528.14C964.16,-1561.93 1053.58,-1652.19 1072.74,-1671.53"/>
+</g>
+<!-- e_30_target -->
+<g id="node80" class="node">
+<title>e_30_target</title>
+<ellipse fill="black" stroke="black" cx="998.28" cy="-1791.02" rx="1.8" ry="1.8"/>
+</g>
+<!-- h_e&#45;&gt;e_30_target -->
+<g id="edge109" class="edge">
+<title>h_e&#45;&gt;e_30_target</title>
+<path fill="none" stroke="black" d="M923.13,-1532.99C938.22,-1584.8 982.1,-1735.44 994.8,-1779.06"/>
+<polygon fill="black" stroke="black" points="991.48,-1780.17 997.64,-1788.79 998.2,-1778.21 991.48,-1780.17"/>
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+<!-- e_41_center -->
+<g id="node101" class="node">
+<title>e_41_center</title>
+<polygon fill="none" stroke="black" points="623.85,-1525.03 616.85,-1525.03 616.85,-1518.03 623.85,-1518.03 623.85,-1525.03"/>
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+<!-- h_e&#45;&gt;e_41_center -->
+<g id="edge126" class="edge">
+<title>h_e&#45;&gt;e_41_center</title>
+<path fill="none" stroke="black" d="M899.81,-1515.7C840.24,-1516.95 653,-1520.85 624.11,-1521.45"/>
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+<!-- e_46_center -->
+<g id="node108" class="node">
+<title>e_46_center</title>
+<polygon fill="none" stroke="black" points="1009.41,-1702.36 1002.41,-1702.36 1002.41,-1695.36 1009.41,-1695.36 1009.41,-1702.36"/>
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+<!-- h_e&#45;&gt;e_46_center -->
+<g id="edge141" class="edge">
+<title>h_e&#45;&gt;e_46_center</title>
+<path fill="none" stroke="black" d="M925.79,-1531.61C945.12,-1571.97 994.39,-1674.81 1004.2,-1695.29"/>
+</g>
+<!-- e_55_center -->
+<g id="node120" class="node">
+<title>e_55_center</title>
+<polygon fill="none" stroke="black" points="1216.28,-1409.79 1209.28,-1409.79 1209.28,-1402.79 1216.28,-1402.79 1216.28,-1409.79"/>
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+<!-- h_e&#45;&gt;e_55_center -->
+<g id="edge191" class="edge">
+<title>h_e&#45;&gt;e_55_center</title>
+<path fill="none" stroke="black" d="M935.11,-1508.99C993.11,-1487.54 1180.15,-1418.36 1209.02,-1407.68"/>
+</g>
+<!-- e_62_center -->
+<g id="node129" class="node">
+<title>e_62_center</title>
+<polygon fill="none" stroke="black" points="1122.92,-1561.31 1115.92,-1561.31 1115.92,-1554.31 1122.92,-1554.31 1122.92,-1561.31"/>
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+<!-- h_e&#45;&gt;e_62_center -->
+<g id="edge220" class="edge">
+<title>h_e&#45;&gt;e_62_center</title>
+<path fill="none" stroke="black" d="M935.86,-1519.09C980.34,-1528.48 1094.01,-1552.45 1115.78,-1557.04"/>
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+<!-- e_77_center -->
+<g id="node140" class="node">
+<title>e_77_center</title>
+<polygon fill="none" stroke="black" points="684.54,-1447.11 677.54,-1447.11 677.54,-1440.11 684.54,-1440.11 684.54,-1447.11"/>
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+<!-- h_e&#45;&gt;e_77_center -->
+<g id="edge276" class="edge">
+<title>h_e&#45;&gt;e_77_center</title>
+<path fill="none" stroke="black" d="M900.56,-1510.05C850.76,-1494.98 709.76,-1452.31 684.83,-1444.76"/>
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+<!-- e_83_center -->
+<g id="node146" class="node">
+<title>e_83_center</title>
+<polygon fill="none" stroke="black" points="647.66,-1323.57 640.66,-1323.57 640.66,-1316.57 647.66,-1316.57 647.66,-1323.57"/>
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+<!-- h_e&#45;&gt;e_83_center -->
+<g id="edge308" class="edge">
+<title>h_e&#45;&gt;e_83_center</title>
+<path fill="none" stroke="black" d="M903.26,-1504.83C850.83,-1467.44 674.87,-1341.97 647.69,-1322.59"/>
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+<!-- e_86_center -->
+<g id="node148" class="node">
+<title>e_86_center</title>
+<polygon fill="none" stroke="black" points="869.69,-1649.3 862.69,-1649.3 862.69,-1642.3 869.69,-1642.3 869.69,-1649.3"/>
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+<!-- h_e&#45;&gt;e_86_center -->
+<g id="edge314" class="edge">
+<title>h_e&#45;&gt;e_86_center</title>
+<path fill="none" stroke="black" d="M911.32,-1532.11C899.19,-1562.67 874.16,-1625.73 867.73,-1641.94"/>
+</g>
+<!-- e_87_center -->
+<g id="node149" class="node">
+<title>e_87_center</title>
+<polygon fill="none" stroke="black" points="900.54,-1654.28 893.54,-1654.28 893.54,-1647.28 900.54,-1647.28 900.54,-1654.28"/>
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+<!-- h_e&#45;&gt;e_87_center -->
+<g id="edge317" class="edge">
+<title>h_e&#45;&gt;e_87_center</title>
+<path fill="none" stroke="black" d="M915.2,-1533.31C910.22,-1565.55 900.05,-1631.31 897.58,-1647.24"/>
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+<!-- h_e&#45;&gt;e_91_center -->
+<g id="edge337" class="edge">
+<title>h_e&#45;&gt;e_91_center</title>
+<path fill="none" stroke="black" d="M929.5,-1501.22C968.18,-1453.84 1092.2,-1301.94 1113.22,-1276.18"/>
+</g>
+<!-- e_5_center&#45;&gt;h_c -->
+<g id="edge21" class="edge">
+<title>e_5_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M642.01,-1572.71C669.21,-1546.19 832.53,-1387.01 890.78,-1330.22"/>
+<polygon fill="black" stroke="black" points="893.56,-1332.4 898.28,-1322.91 888.68,-1327.39 893.56,-1332.4"/>
+</g>
+<!-- e_5_center&#45;&gt;ac_c -->
+<g id="edge20" class="edge">
+<title>e_5_center&#45;&gt;ac_c</title>
+<path fill="none" stroke="black" d="M634.39,-1573.37C611.76,-1554.69 493.04,-1456.68 443.38,-1415.69"/>
+<polygon fill="black" stroke="black" points="445.43,-1412.85 435.49,-1409.18 440.97,-1418.24 445.43,-1412.85"/>
+</g>
+<!-- amp_c -->
+<g id="node23" class="node">
+<title>amp_c</title>
+<ellipse fill="none" stroke="black" cx="426.43" cy="-860.23" rx="18" ry="18"/>
+<text text-anchor="middle" x="426.43" y="-856.53" font-family="Times,serif" font-size="14.00">amp_c</text>
+</g>
+<!-- amp_c&#45;&gt;e_6_center -->
+<g id="edge23" class="edge">
+<title>amp_c&#45;&gt;e_6_center</title>
+<path fill="none" stroke="black" d="M442.75,-868.63C466.44,-880.81 508.9,-902.64 521.59,-909.17"/>
+</g>
+<!-- e_6_center&#45;&gt;adp_c -->
+<g id="edge24" class="edge">
+<title>e_6_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" d="M528.93,-912.87C548.85,-922.72 645.04,-970.3 691.66,-993.37"/>
+<polygon fill="black" stroke="black" points="690.3,-996.6 700.81,-997.89 693.4,-990.32 690.3,-996.6"/>
+</g>
+<!-- akg_c -->
+<g id="node25" class="node">
+<title>akg_c</title>
+<ellipse fill="none" stroke="black" cx="1166.85" cy="-1189.81" rx="18" ry="18"/>
+<text text-anchor="middle" x="1166.85" y="-1186.11" font-family="Times,serif" font-size="14.00">akg_c</text>
+</g>
+<!-- akg_c&#45;&gt;e_7_center -->
+<g id="edge27" class="edge">
+<title>akg_c&#45;&gt;e_7_center</title>
+<path fill="none" stroke="black" d="M1149.81,-1196.6C1130.45,-1204.31 1100.24,-1216.35 1090,-1220.43"/>
+</g>
+<!-- akg_c&#45;&gt;e_54_center -->
+<g id="edge188" class="edge">
+<title>akg_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" d="M1153.82,-1176.86C1135.84,-1159 1104.43,-1127.8 1093.73,-1117.17"/>
+</g>
+<!-- co2_c -->
+<g id="node26" class="node">
+<title>co2_c</title>
+<ellipse fill="none" stroke="black" cx="1132.22" cy="-954.15" rx="18" ry="18"/>
+<text text-anchor="middle" x="1132.22" y="-950.45" font-family="Times,serif" font-size="14.00">co2_c</text>
+</g>
+<!-- co2_c&#45;&gt;e_78_center -->
+<g id="edge280" class="edge">
+<title>co2_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="black" d="M1115.28,-960.42C1104.12,-964.48 1089.17,-969.79 1075.82,-974.08 999.73,-998.5 905.35,-1023.92 885.61,-1029.19"/>
+</g>
+<!-- succoa_c -->
+<g id="node27" class="node">
+<title>succoa_c</title>
+<ellipse fill="none" stroke="black" cx="946.22" cy="-1392.43" rx="18" ry="18"/>
+<text text-anchor="middle" x="946.22" y="-1388.73" font-family="Times,serif" font-size="14.00">succoa_c</text>
+</g>
+<!-- e_7_center&#45;&gt;nadh_c -->
+<g id="edge29" class="edge">
+<title>e_7_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" d="M1082.78,-1219.98C1080.07,-1218.61 1076.12,-1216.62 1071.82,-1214.45"/>
+<polygon fill="black" stroke="black" points="1073.27,-1211.26 1062.76,-1209.89 1070.12,-1217.52 1073.27,-1211.26"/>
+</g>
+<!-- e_7_center&#45;&gt;co2_c -->
+<g id="edge28" class="edge">
+<title>e_7_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" d="M1084.75,-1218.11C1081.66,-1211.05 1075.55,-1195.19 1076.08,-1181.22 1077.16,-1152.61 1089.14,-1147.8 1096.73,-1120.2 1109.92,-1072.24 1121.14,-1015.36 1127.26,-982.16"/>
+<polygon fill="black" stroke="black" points="1130.71,-982.71 1129.06,-972.25 1123.82,-981.46 1130.71,-982.71"/>
+</g>
+<!-- e_7_center&#45;&gt;succoa_c -->
+<g id="edge30" class="edge">
+<title>e_7_center&#45;&gt;succoa_c</title>
+<path fill="none" stroke="black" d="M1084.1,-1225.65C1073.99,-1241.74 1033.17,-1305.38 991.77,-1351.28 984.64,-1359.18 976.14,-1367.18 968.42,-1374"/>
+<polygon fill="black" stroke="black" points="965.74,-1371.69 960.46,-1380.87 970.32,-1376.99 965.74,-1371.69"/>
+</g>
+<!-- akg_e -->
+<g id="node29" class="node">
+<title>akg_e</title>
+<ellipse fill="none" stroke="black" cx="1509.21" cy="-1660.96" rx="18" ry="18"/>
+<text text-anchor="middle" x="1509.21" y="-1657.26" font-family="Times,serif" font-size="14.00">akg_e</text>
+</g>
+<!-- akg_e&#45;&gt;e_8_center -->
+<g id="edge31" class="edge">
+<title>akg_e&#45;&gt;e_8_center</title>
+<path fill="none" stroke="black" d="M1493.72,-1651.17C1436.39,-1614.95 1238.05,-1489.61 1208.92,-1471.21"/>
+</g>
+<!-- e_21_target -->
+<g id="node65" class="node">
+<title>e_21_target</title>
+<ellipse fill="black" stroke="black" cx="1735.18" cy="-1802.02" rx="1.8" ry="1.8"/>
+</g>
+<!-- akg_e&#45;&gt;e_21_target -->
+<g id="edge100" class="edge">
+<title>akg_e&#45;&gt;e_21_target</title>
+<path fill="none" stroke="black" d="M1524.74,-1670.66C1567.93,-1697.62 1688.64,-1772.97 1724.81,-1795.55"/>
+<polygon fill="black" stroke="black" points="1723.04,-1798.57 1733.38,-1800.89 1726.75,-1792.63 1723.04,-1798.57"/>
+</g>
+<!-- e_8_center&#45;&gt;h_c -->
+<g id="edge33" class="edge">
+<title>e_8_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1201.79,-1467.54C1179.41,-1458.65 1055.75,-1408.52 964.05,-1351.22 953.36,-1344.54 942.25,-1336.12 933.02,-1328.64"/>
+<polygon fill="black" stroke="black" points="935.06,-1325.79 925.12,-1322.12 930.6,-1331.19 935.06,-1325.79"/>
+</g>
+<!-- e_8_center&#45;&gt;akg_c -->
+<g id="edge34" class="edge">
+<title>e_8_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="black" d="M1204.85,-1465.41C1201.33,-1439.89 1179.66,-1282.69 1170.71,-1217.79"/>
+<polygon fill="black" stroke="black" points="1174.17,-1217.28 1169.34,-1207.85 1167.24,-1218.23 1174.17,-1217.28"/>
+</g>
+<!-- etoh_c -->
+<g id="node31" class="node">
+<title>etoh_c</title>
+<ellipse fill="none" stroke="black" cx="1289.88" cy="-1612.42" rx="18" ry="18"/>
+<text text-anchor="middle" x="1289.88" y="-1608.72" font-family="Times,serif" font-size="14.00">etoh_c</text>
+</g>
+<!-- etoh_c&#45;&gt;e_9_center -->
+<g id="edge35" class="edge">
+<title>etoh_c&#45;&gt;e_9_center</title>
+<path fill="none" stroke="black" d="M1284.84,-1594.84C1269.92,-1542.83 1226.58,-1391.74 1219.24,-1366.16"/>
+</g>
+<!-- e_9_center&#45;&gt;acald_c -->
+<g id="edge38" class="edge">
+<title>e_9_center&#45;&gt;acald_c</title>
+<path fill="none" stroke="black" d="M1222.03,-1362.65C1246.16,-1363.89 1377.16,-1370.59 1435.58,-1373.58"/>
+<polygon fill="black" stroke="black" points="1435.44,-1377.07 1445.6,-1374.09 1435.8,-1370.08 1435.44,-1377.07"/>
+</g>
+<!-- e_9_center&#45;&gt;nadh_c -->
+<g id="edge37" class="edge">
+<title>e_9_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" d="M1214.67,-1358.64C1202.43,-1345.38 1160.37,-1300.26 1122.97,-1265.75 1113.15,-1256.69 1087.41,-1235.3 1068.48,-1219.72"/>
+<polygon fill="black" stroke="black" points="1070.55,-1216.89 1060.6,-1213.25 1066.1,-1222.3 1070.55,-1216.89"/>
+</g>
+<!-- e_9_center&#45;&gt;h_c -->
+<g id="edge39" class="edge">
+<title>e_9_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1214.52,-1361.68C1192.47,-1357.01 1074.87,-1332.37 977.98,-1317.79 965.47,-1315.91 951.58,-1314.24 939.74,-1312.95"/>
+<polygon fill="black" stroke="black" points="939.85,-1309.44 929.54,-1311.86 939.11,-1316.4 939.85,-1309.44"/>
+</g>
+<!-- pi_c -->
+<g id="node33" class="node">
+<title>pi_c</title>
+<ellipse fill="none" stroke="black" cx="774.55" cy="-1104.66" rx="18" ry="18"/>
+<text text-anchor="middle" x="774.55" y="-1100.96" font-family="Times,serif" font-size="14.00">pi_c</text>
+</g>
+<!-- pi_c&#45;&gt;e_11_center -->
+<g id="edge45" class="edge">
+<title>pi_c&#45;&gt;e_11_center</title>
+<path fill="none" stroke="black" d="M775.68,-1122.88C777.72,-1155.94 781.91,-1223.9 782.93,-1240.38"/>
+</g>
+<!-- pi_c&#45;&gt;e_48_center -->
+<g id="edge150" class="edge">
+<title>pi_c&#45;&gt;e_48_center</title>
+<path fill="none" stroke="black" d="M792.07,-1099.39C806.52,-1094.63 827.22,-1086.81 843.61,-1076.65 903.33,-1039.62 958.93,-972.19 971.89,-955.91"/>
+</g>
+<!-- pi_c&#45;&gt;e_81_center -->
+<g id="edge299" class="edge">
+<title>pi_c&#45;&gt;e_81_center</title>
+<path fill="none" stroke="black" d="M756.7,-1107.12C715.56,-1112.8 616.07,-1126.54 595.54,-1129.38"/>
+</g>
+<!-- e_10_center&#45;&gt;h_c -->
+<g id="edge43" class="edge">
+<title>e_10_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M711.92,-1182.98C732.59,-1196.16 838.91,-1263.91 887.33,-1294.77"/>
+<polygon fill="black" stroke="black" points="885.62,-1297.83 895.94,-1300.25 889.38,-1291.93 885.62,-1297.83"/>
+</g>
+<!-- e_10_center&#45;&gt;adp_c -->
+<g id="edge44" class="edge">
+<title>e_10_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" d="M707.75,-1177.07C705.16,-1161.57 695.84,-1099.88 702.72,-1049.86 703.51,-1044.1 705.01,-1038.08 706.75,-1032.41"/>
+<polygon fill="black" stroke="black" points="710.14,-1033.31 710.04,-1022.71 703.51,-1031.05 710.14,-1033.31"/>
+</g>
+<!-- e_10_center&#45;&gt;pi_c -->
+<g id="edge42" class="edge">
+<title>e_10_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" d="M711.88,-1177.17C717.92,-1170.97 730.63,-1157.76 740.82,-1146.09 746.11,-1140.04 751.68,-1133.34 756.73,-1127.12"/>
+<polygon fill="black" stroke="black" points="759.69,-1129.03 763.24,-1119.05 754.24,-1124.64 759.69,-1129.03"/>
+</g>
+<!-- e_11_center&#45;&gt;h_c -->
+<g id="edge50" class="edge">
+<title>e_11_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M786.86,-1245.94C801.22,-1253.34 854.1,-1280.59 886.16,-1297.1"/>
+<polygon fill="black" stroke="black" points="884.88,-1300.38 895.38,-1301.85 888.09,-1294.16 884.88,-1300.38"/>
+</g>
+<!-- e_11_center&#45;&gt;atp_c -->
+<g id="edge48" class="edge">
+<title>e_11_center&#45;&gt;atp_c</title>
+<path fill="none" stroke="black" d="M781.99,-1240.33C775.74,-1220.36 745.74,-1124.69 730.8,-1077.06"/>
+<polygon fill="black" stroke="black" points="734.11,-1075.89 727.77,-1067.39 727.43,-1077.98 734.11,-1075.89"/>
+</g>
+<!-- e_11_center&#45;&gt;h2o_c -->
+<g id="edge49" class="edge">
+<title>e_11_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="black" d="M781.29,-1240.31C774.92,-1227.64 753.68,-1185.38 739.73,-1157.61"/>
+<polygon fill="black" stroke="black" points="742.75,-1155.82 735.13,-1148.46 736.49,-1158.97 742.75,-1155.82"/>
+</g>
+<!-- nadph_c -->
+<g id="node36" class="node">
+<title>nadph_c</title>
+<ellipse fill="none" stroke="black" cx="1159.98" cy="-1014.03" rx="18" ry="18"/>
+<text text-anchor="middle" x="1159.98" y="-1010.33" font-family="Times,serif" font-size="14.00">nadph_c</text>
+</g>
+<!-- nadph_c&#45;&gt;e_12_center -->
+<g id="edge51" class="edge">
+<title>nadph_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M1143.23,-1007.27C1102.04,-990.7 998.02,-949.16 981.42,-945.6 971.58,-943.49 959.63,-943.49 953.69,-943.66"/>
+</g>
+<!-- nadph_c&#45;&gt;e_54_center -->
+<g id="edge186" class="edge">
+<title>nadph_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" d="M1149.36,-1029.14C1132.85,-1052.62 1101.96,-1096.53 1092.71,-1109.68"/>
+</g>
+<!-- nadph_c&#45;&gt;e_67_center -->
+<g id="edge245" class="edge">
+<title>nadph_c&#45;&gt;e_67_center</title>
+<path fill="none" stroke="black" d="M1175.22,-1024.3C1184.89,-1031.13 1197.42,-1040.58 1207.46,-1050.17 1237.21,-1078.6 1266.83,-1118.9 1275.75,-1131.36"/>
+</g>
+<!-- g3p_c -->
+<g id="node37" class="node">
+<title>g3p_c</title>
+<ellipse fill="none" stroke="black" cx="1021.46" cy="-580.96" rx="18" ry="18"/>
+<text text-anchor="middle" x="1021.46" y="-577.26" font-family="Times,serif" font-size="14.00">g3p_c</text>
+</g>
+<!-- g3p_c&#45;&gt;e_12_center -->
+<g id="edge52" class="edge">
+<title>g3p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M1017.92,-598.95C1004.5,-667.02 957.29,-906.6 950.72,-939.95"/>
+</g>
+<!-- g3p_c&#45;&gt;e_48_center -->
+<g id="edge152" class="edge">
+<title>g3p_c&#45;&gt;e_48_center</title>
+<path fill="none" stroke="black" d="M1019.21,-598.87C1010.49,-668.12 979.28,-916.12 975.17,-948.75"/>
+</g>
+<!-- e_90_center -->
+<g id="node153" class="node">
+<title>e_90_center</title>
+<polygon fill="none" stroke="black" points="1065.65,-407.95 1058.65,-407.95 1058.65,-400.95 1065.65,-400.95 1065.65,-407.95"/>
+</g>
+<!-- g3p_c&#45;&gt;e_90_center -->
+<g id="edge332" class="edge">
+<title>g3p_c&#45;&gt;e_90_center</title>
+<path fill="none" stroke="black" d="M1025.51,-563.39C1034.72,-523.45 1056.77,-427.78 1061.32,-408.05"/>
+</g>
+<!-- glu__L_c -->
+<g id="node38" class="node">
+<title>glu__L_c</title>
+<ellipse fill="none" stroke="black" cx="1150.94" cy="-1115.12" rx="18" ry="18"/>
+<text text-anchor="middle" x="1150.94" y="-1111.42" font-family="Times,serif" font-size="14.00">glu__L_c</text>
+</g>
+<!-- glu__L_c&#45;&gt;e_12_center -->
+<g id="edge53" class="edge">
+<title>glu__L_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M1137.12,-1103.35C1095.97,-1068.27 975.69,-965.75 953.5,-946.84"/>
+</g>
+<!-- glu__L_c&#45;&gt;e_50_center -->
+<g id="edge161" class="edge">
+<title>glu__L_c&#45;&gt;e_50_center</title>
+<path fill="none" stroke="black" d="M1133.87,-1108.47C1091.59,-1092 983.84,-1050.04 962.39,-1041.68"/>
+</g>
+<!-- glu__L_c&#45;&gt;e_52_center -->
+<g id="edge176" class="edge">
+<title>glu__L_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="black" d="M1132.88,-1111.93C1109.63,-1107.81 1070.78,-1100.94 1058.66,-1098.8"/>
+</g>
+<!-- oaa_c -->
+<g id="node39" class="node">
+<title>oaa_c</title>
+<ellipse fill="none" stroke="black" cx="829.84" cy="-1062.7" rx="18" ry="18"/>
+<text text-anchor="middle" x="829.84" y="-1059" font-family="Times,serif" font-size="14.00">oaa_c</text>
+</g>
+<!-- oaa_c&#45;&gt;e_12_center -->
+<g id="edge54" class="edge">
+<title>oaa_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M842.7,-1049.97C869.57,-1023.38 930.5,-963.08 946.21,-947.53"/>
+</g>
+<!-- oaa_c&#45;&gt;e_14_center -->
+<g id="edge77" class="edge">
+<title>oaa_c&#45;&gt;e_14_center</title>
+<path fill="none" stroke="black" d="M819.62,-1077.95C811.62,-1089.51 799.95,-1105.55 788.39,-1118.53 758.66,-1151.93 751,-1160.79 715.09,-1187.43 697.33,-1200.61 673.51,-1212.57 664.57,-1216.88"/>
+</g>
+<!-- oaa_c&#45;&gt;e_79_center -->
+<g id="edge287" class="edge">
+<title>oaa_c&#45;&gt;e_79_center</title>
+<path fill="none" stroke="black" d="M834.24,-1045.12C843.94,-1006.38 866.69,-915.55 871.55,-896.14"/>
+</g>
+<!-- pyr_c -->
+<g id="node40" class="node">
+<title>pyr_c</title>
+<ellipse fill="none" stroke="black" cx="793.8" cy="-978.37" rx="18" ry="18"/>
+<text text-anchor="middle" x="793.8" y="-974.67" font-family="Times,serif" font-size="14.00">pyr_c</text>
+</g>
+<!-- pyr_c&#45;&gt;e_12_center -->
+<g id="edge55" class="edge">
+<title>pyr_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M810.55,-971.36C827,-964.8 852.97,-955.28 876.37,-950.34 902.73,-944.78 935.36,-943.96 946.24,-943.84"/>
+</g>
+<!-- pyr_c&#45;&gt;e_70_center -->
+<g id="edge252" class="edge">
+<title>pyr_c&#45;&gt;e_70_center</title>
+<path fill="none" stroke="black" d="M808.15,-989.47C824.14,-1001.65 850.94,-1021.51 875.19,-1036.88 905.29,-1055.96 943.67,-1075.66 955.46,-1081.61"/>
+</g>
+<!-- pyr_c&#45;&gt;e_72_center -->
+<g id="edge263" class="edge">
+<title>pyr_c&#45;&gt;e_72_center</title>
+<path fill="none" stroke="black" d="M783.82,-993.68C772.5,-1010.93 753.36,-1039.72 736.09,-1063.93 690.78,-1127.45 632.31,-1202.49 618.41,-1220.26"/>
+</g>
+<!-- pyr_c&#45;&gt;e_80_center -->
+<g id="edge292" class="edge">
+<title>pyr_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="black" d="M775.49,-977.28C756.21,-976.97 725.63,-978.93 703.28,-992.05 689.34,-1000.23 674.97,-1013.03 668.31,-1019.24"/>
+</g>
+<!-- e4p_c -->
+<g id="node41" class="node">
+<title>e4p_c</title>
+<ellipse fill="none" stroke="black" cx="1070.84" cy="-611.61" rx="18" ry="18"/>
+<text text-anchor="middle" x="1070.84" y="-607.91" font-family="Times,serif" font-size="14.00">e4p_c</text>
+</g>
+<!-- e4p_c&#45;&gt;e_12_center -->
+<g id="edge56" class="edge">
+<title>e4p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M1064.68,-628.54C1041.78,-691.48 962.3,-909.89 951.24,-940.3"/>
+</g>
+<!-- e_93_center -->
+<g id="node156" class="node">
+<title>e_93_center</title>
+<polygon fill="none" stroke="black" points="1126.15,-449.18 1119.15,-449.18 1119.15,-442.18 1126.15,-442.18 1126.15,-449.18"/>
+</g>
+<!-- e4p_c&#45;&gt;e_93_center -->
+<g id="edge345" class="edge">
+<title>e4p_c&#45;&gt;e_93_center</title>
+<path fill="none" stroke="black" d="M1076.29,-594.16C1088.13,-556.22 1115.65,-468.08 1121.53,-449.26"/>
+</g>
+<!-- r5p_c -->
+<g id="node42" class="node">
+<title>r5p_c</title>
+<ellipse fill="none" stroke="black" cx="1154.37" cy="-628.38" rx="18" ry="18"/>
+<text text-anchor="middle" x="1154.37" y="-624.68" font-family="Times,serif" font-size="14.00">r5p_c</text>
+</g>
+<!-- r5p_c&#45;&gt;e_12_center -->
+<g id="edge57" class="edge">
+<title>r5p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M1144.51,-643.59C1106.71,-701.92 972.15,-909.57 952.39,-940.07"/>
+</g>
+<!-- ru5p__D_c -->
+<g id="node122" class="node">
+<title>ru5p__D_c</title>
+<ellipse fill="none" stroke="black" cx="1362.9" cy="-542.19" rx="18" ry="18"/>
+<text text-anchor="middle" x="1362.9" y="-538.49" font-family="Times,serif" font-size="14.00">ru5p__D_c</text>
+</g>
+<!-- r5p_c&#45;&gt;ru5p__D_c -->
+<g id="edge312" class="edge">
+<title>r5p_c&#45;&gt;ru5p__D_c</title>
+<path fill="none" stroke="black" d="M1171.08,-621.47C1207.3,-606.5 1293.29,-570.96 1336.76,-552.99"/>
+<polygon fill="black" stroke="black" points="1338.2,-556.18 1346.11,-549.13 1335.53,-549.71 1338.2,-556.18"/>
+</g>
+<!-- e_92_center -->
+<g id="node155" class="node">
+<title>e_92_center</title>
+<polygon fill="none" stroke="black" points="1189.53,-381.22 1182.53,-381.22 1182.53,-374.22 1189.53,-374.22 1189.53,-381.22"/>
+</g>
+<!-- r5p_c&#45;&gt;e_92_center -->
+<g id="edge341" class="edge">
+<title>r5p_c&#45;&gt;e_92_center</title>
+<path fill="none" stroke="black" d="M1156.64,-610.35C1163.28,-557.81 1182.34,-406.95 1185.56,-381.41"/>
+</g>
+<!-- gln__L_c -->
+<g id="node43" class="node">
+<title>gln__L_c</title>
+<ellipse fill="none" stroke="black" cx="876.28" cy="-969.94" rx="18" ry="18"/>
+<text text-anchor="middle" x="876.28" y="-966.24" font-family="Times,serif" font-size="14.00">gln__L_c</text>
+</g>
+<!-- gln__L_c&#45;&gt;e_12_center -->
+<g id="edge59" class="edge">
+<title>gln__L_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M893.37,-963.88C910.88,-957.67 936.85,-948.47 946.33,-945.11"/>
+</g>
+<!-- gln__L_c&#45;&gt;e_53_center -->
+<g id="edge182" class="edge">
+<title>gln__L_c&#45;&gt;e_53_center</title>
+<path fill="none" stroke="black" d="M894.46,-970.47C928.69,-971.46 1000.81,-973.55 1018.3,-974.06"/>
+</g>
+<!-- gln__L_c&#45;&gt;e_54_center -->
+<g id="edge187" class="edge">
+<title>gln__L_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" d="M891.94,-979.61C924.22,-999.67 1000.27,-1047.6 1061.63,-1091.44 1070.78,-1097.97 1081.1,-1106.22 1086.43,-1110.54"/>
+</g>
+<!-- g6p_c -->
+<g id="node44" class="node">
+<title>g6p_c</title>
+<ellipse fill="none" stroke="black" cx="920.29" cy="-740.82" rx="18" ry="18"/>
+<text text-anchor="middle" x="920.29" y="-737.12" font-family="Times,serif" font-size="14.00">g6p_c</text>
+</g>
+<!-- f6p_c -->
+<g id="node46" class="node">
+<title>f6p_c</title>
+<ellipse fill="none" stroke="black" cx="934.92" cy="-649.11" rx="18" ry="18"/>
+<text text-anchor="middle" x="934.92" y="-645.41" font-family="Times,serif" font-size="14.00">f6p_c</text>
+</g>
+<!-- g6p_c&#45;&gt;f6p_c -->
+<g id="edge266" class="edge">
+<title>g6p_c&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" d="M923.18,-722.7C925.24,-709.76 928.06,-692.1 930.42,-677.33"/>
+<polygon fill="black" stroke="black" points="933.92,-677.61 932.04,-667.19 927,-676.51 933.92,-677.61"/>
+</g>
+<!-- g6p_c&#45;&gt;e_12_center -->
+<g id="edge60" class="edge">
+<title>g6p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M922.92,-758.83C929.48,-803.66 946.22,-918.21 949.42,-940.15"/>
+</g>
+<!-- e_47_center -->
+<g id="node110" class="node">
+<title>e_47_center</title>
+<polygon fill="none" stroke="black" points="1072.62,-970.88 1065.62,-970.88 1065.62,-963.88 1072.62,-963.88 1072.62,-970.88"/>
+</g>
+<!-- g6p_c&#45;&gt;e_47_center -->
+<g id="edge146" class="edge">
+<title>g6p_c&#45;&gt;e_47_center</title>
+<path fill="none" stroke="black" d="M930.29,-756.03C960.66,-802.27 1050.75,-939.41 1066.7,-963.68"/>
+</g>
+<!-- pep_c -->
+<g id="node45" class="node">
+<title>pep_c</title>
+<ellipse fill="none" stroke="black" cx="744.99" cy="-829.05" rx="18" ry="18"/>
+<text text-anchor="middle" x="744.99" y="-825.35" font-family="Times,serif" font-size="14.00">pep_c</text>
+</g>
+<!-- pep_c&#45;&gt;e_12_center -->
+<g id="edge61" class="edge">
+<title>pep_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M760.51,-838.32C783.4,-851.92 827.61,-877.97 865.77,-899.15 896.73,-916.34 934.76,-936 946.4,-941.99"/>
+</g>
+<!-- e_44_center -->
+<g id="node105" class="node">
+<title>e_44_center</title>
+<polygon fill="none" stroke="black" points="738.79,-600 731.79,-600 731.79,-593 738.79,-593 738.79,-600"/>
+</g>
+<!-- pep_c&#45;&gt;e_44_center -->
+<g id="edge135" class="edge">
+<title>pep_c&#45;&gt;e_44_center</title>
+<path fill="none" stroke="black" d="M744.82,-810.86C744.54,-786.55 743.85,-742.15 742.21,-704.27 740.45,-663.44 736.67,-614 735.59,-600.22"/>
+</g>
+<!-- e_49_center -->
+<g id="node113" class="node">
+<title>e_49_center</title>
+<polygon fill="none" stroke="black" points="684.17,-637.74 677.17,-637.74 677.17,-630.74 684.17,-630.74 684.17,-637.74"/>
+</g>
+<!-- pep_c&#45;&gt;e_49_center -->
+<g id="edge157" class="edge">
+<title>pep_c&#45;&gt;e_49_center</title>
+<path fill="none" stroke="black" d="M739.06,-811.71C730.86,-787.63 715.62,-742.68 703.01,-704.22 694.67,-678.77 684.98,-647.99 681.76,-637.74"/>
+</g>
+<!-- pep_c&#45;&gt;e_78_center -->
+<g id="edge281" class="edge">
+<title>pep_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="black" d="M755.28,-844.17C784,-886.38 863.98,-1003.87 879.32,-1026.41"/>
+</g>
+<!-- pep_c&#45;&gt;e_82_center -->
+<g id="edge302" class="edge">
+<title>pep_c&#45;&gt;e_82_center</title>
+<path fill="none" stroke="black" d="M747.69,-846.87C754.76,-893.33 773.43,-1016.12 776.86,-1038.74"/>
+</g>
+<!-- f6p_c&#45;&gt;e_12_center -->
+<g id="edge64" class="edge">
+<title>f6p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M935.93,-667.39C936.96,-685.91 938.57,-715.38 939.89,-740.88 944.08,-821.55 948.83,-920.29 949.79,-940.22"/>
+</g>
+<!-- f6p_c&#45;&gt;e_71_center -->
+<g id="edge258" class="edge">
+<title>f6p_c&#45;&gt;e_71_center</title>
+<path fill="none" stroke="black" d="M928.47,-666.05C908.78,-717.77 850.23,-871.62 840.31,-897.68"/>
+</g>
+<!-- 3pg_c -->
+<g id="node47" class="node">
+<title>3pg_c</title>
+<ellipse fill="none" stroke="black" cx="722.61" cy="-704.24" rx="18" ry="18"/>
+<text text-anchor="middle" x="722.61" y="-700.54" font-family="Times,serif" font-size="14.00">3pg_c</text>
+</g>
+<!-- 3pg_c&#45;&gt;e_12_center -->
+<g id="edge65" class="edge">
+<title>3pg_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" d="M735.16,-717.47C778.72,-763.37 922.11,-914.48 946.44,-940.11"/>
+</g>
+<!-- 3pg_c&#45;&gt;e_74_center -->
+<g id="edge267" class="edge">
+<title>3pg_c&#45;&gt;e_74_center</title>
+<path fill="none" stroke="black" d="M713.58,-720.35C699.74,-745.04 674.12,-790.76 666.81,-803.79"/>
+</g>
+<!-- nadp_c -->
+<g id="node48" class="node">
+<title>nadp_c</title>
+<ellipse fill="none" stroke="black" cx="1193.56" cy="-1063.99" rx="18" ry="18"/>
+<text text-anchor="middle" x="1193.56" y="-1060.29" font-family="Times,serif" font-size="14.00">nadp_c</text>
+</g>
+<!-- nadp_c&#45;&gt;e_47_center -->
+<g id="edge145" class="edge">
+<title>nadp_c&#45;&gt;e_47_center</title>
+<path fill="none" stroke="black" d="M1178.96,-1052.96C1169.54,-1045.83 1157.04,-1036.31 1146.05,-1027.82 1117.57,-1005.79 1083.5,-978.79 1072.64,-970.17"/>
+</g>
+<!-- nadp_c&#45;&gt;e_52_center -->
+<g id="edge174" class="edge">
+<title>nadp_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="black" d="M1176,-1068.31C1143.36,-1076.35 1075.15,-1093.16 1058.6,-1097.23"/>
+</g>
+<!-- e_56_center -->
+<g id="node123" class="node">
+<title>e_56_center</title>
+<polygon fill="none" stroke="black" points="1306.83,-829.22 1299.83,-829.22 1299.83,-822.22 1306.83,-822.22 1306.83,-829.22"/>
+</g>
+<!-- nadp_c&#45;&gt;e_56_center -->
+<g id="edge195" class="edge">
+<title>nadp_c&#45;&gt;e_56_center</title>
+<path fill="none" stroke="black" d="M1197.91,-1046.12C1205.36,-1017.18 1222.12,-958.74 1246.08,-913.5 1264.3,-879.09 1292.07,-840.87 1300.69,-829.25"/>
+</g>
+<!-- nadp_c&#45;&gt;e_58_center -->
+<g id="edge201" class="edge">
+<title>nadp_c&#45;&gt;e_58_center</title>
+<path fill="none" stroke="black" d="M1178.03,-1073.57C1159.1,-1085.12 1126.01,-1104.88 1096.73,-1120.2 1060.67,-1139.06 1015.51,-1158.87 1002.27,-1164.6"/>
+</g>
+<!-- e_65_center -->
+<g id="node132" class="node">
+<title>e_65_center</title>
+<polygon fill="none" stroke="black" points="1040.46,-1064.75 1033.46,-1064.75 1033.46,-1057.75 1040.46,-1057.75 1040.46,-1064.75"/>
+</g>
+<!-- nadp_c&#45;&gt;e_65_center -->
+<g id="edge235" class="edge">
+<title>nadp_c&#45;&gt;e_65_center</title>
+<path fill="none" stroke="black" d="M1175.29,-1063.67C1138.82,-1063.03 1058.93,-1061.64 1040.71,-1061.32"/>
+</g>
+<!-- nadp_c&#45;&gt;e_91_center -->
+<g id="edge335" class="edge">
+<title>nadp_c&#45;&gt;e_91_center</title>
+<path fill="none" stroke="black" d="M1187.23,-1081.05C1170.51,-1126.17 1125.81,-1246.7 1117.58,-1268.91"/>
+</g>
+<!-- e_12_center&#45;&gt;coa_c -->
+<g id="edge72" class="edge">
+<title>e_12_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" d="M948.6,-947.57C939.4,-973.01 885.86,-1121 863.61,-1182.49"/>
+<polygon fill="black" stroke="black" points="860.19,-1181.66 860.07,-1192.26 866.77,-1184.04 860.19,-1181.66"/>
+</g>
+<!-- e_12_center&#45;&gt;nadh_c -->
+<g id="edge68" class="edge">
+<title>e_12_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" d="M951.32,-947.46C960.55,-972.12 1014.12,-1115.25 1036.56,-1175.24"/>
+<polygon fill="black" stroke="black" points="1033.35,-1176.64 1040.13,-1184.78 1039.91,-1174.19 1033.35,-1176.64"/>
+</g>
+<!-- e_12_center&#45;&gt;h_c -->
+<g id="edge70" class="edge">
+<title>e_12_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M949.58,-947.44C946.3,-978.6 922.8,-1201.94 914.39,-1281.81"/>
+<polygon fill="black" stroke="black" points="910.88,-1281.78 913.31,-1292.09 917.84,-1282.51 910.88,-1281.78"/>
+</g>
+<!-- e_12_center&#45;&gt;adp_c -->
+<g id="edge73" class="edge">
+<title>e_12_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" d="M946.22,-943.76C935.3,-943.67 902.55,-943.99 876.37,-950.34 835.16,-960.34 834.83,-987.66 793.7,-997.97 778.09,-1001.88 760.24,-1003.88 745.69,-1004.9"/>
+<polygon fill="black" stroke="black" points="745.09,-1001.43 735.31,-1005.5 745.49,-1008.41 745.09,-1001.43"/>
+</g>
+<!-- e_12_center&#45;&gt;akg_c -->
+<g id="edge71" class="edge">
+<title>e_12_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="black" d="M953.2,-947.34C969.09,-964.58 1040.16,-1041.95 1096.73,-1106.8 1114.58,-1127.26 1134.52,-1150.95 1148.56,-1167.77"/>
+<polygon fill="black" stroke="black" points="1146.23,-1170.45 1155.32,-1175.89 1151.61,-1165.97 1146.23,-1170.45"/>
+</g>
+<!-- e_12_center&#45;&gt;pi_c -->
+<g id="edge69" class="edge">
+<title>e_12_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" d="M946.37,-946.11C930.12,-956.57 862.24,-1001.37 816.08,-1048.74 806.68,-1058.39 797.6,-1070.23 790.34,-1080.52"/>
+<polygon fill="black" stroke="black" points="787.24,-1078.85 784.46,-1089.08 793.01,-1082.81 787.24,-1078.85"/>
+</g>
+<!-- e_12_center&#45;&gt;nadp_c -->
+<g id="edge67" class="edge">
+<title>e_12_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="black" d="M953.61,-947.39C957.11,-950.68 962.63,-955.57 968.02,-959 1035.47,-1001.97 1123.33,-1037.7 1166.8,-1054.19"/>
+<polygon fill="black" stroke="black" points="1165.77,-1057.54 1176.36,-1057.78 1168.23,-1050.99 1165.77,-1057.54"/>
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+<!-- co2_e -->
+<g id="node50" class="node">
+<title>co2_e</title>
+<ellipse fill="none" stroke="black" cx="1465.37" cy="-728.13" rx="18" ry="18"/>
+<text text-anchor="middle" x="1465.37" y="-724.43" font-family="Times,serif" font-size="14.00">co2_e</text>
+</g>
+<!-- co2_e&#45;&gt;co2_c -->
+<g id="edge74" class="edge">
+<title>co2_e&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" d="M1450.19,-738.43C1397.18,-774.39 1220.07,-894.55 1155.78,-938.16"/>
+<polygon fill="black" stroke="black" points="1153.8,-935.28 1147.49,-943.79 1157.73,-941.07 1153.8,-935.28"/>
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+<!-- e_22_target -->
+<g id="node66" class="node">
+<title>e_22_target</title>
+<ellipse fill="black" stroke="black" cx="1684.99" cy="-570.23" rx="1.8" ry="1.8"/>
+</g>
+<!-- co2_e&#45;&gt;e_22_target -->
+<g id="edge101" class="edge">
+<title>co2_e&#45;&gt;e_22_target</title>
+<path fill="none" stroke="black" d="M1480.12,-717.53C1521.78,-687.58 1639.56,-602.89 1674.87,-577.51"/>
+<polygon fill="black" stroke="black" points="1677.15,-580.18 1683.23,-571.5 1673.07,-574.49 1677.15,-580.18"/>
+</g>
+<!-- e_14_center&#45;&gt;coa_c -->
+<g id="edge79" class="edge">
+<title>e_14_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" d="M664.65,-1218.4C684.32,-1217.45 777.85,-1212.94 825.65,-1210.64"/>
+<polygon fill="black" stroke="black" points="825.84,-1214.13 835.66,-1210.16 825.5,-1207.14 825.84,-1214.13"/>
+</g>
+<!-- e_14_center&#45;&gt;h_c -->
+<g id="edge80" class="edge">
+<title>e_14_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M664.51,-1219.87C688.29,-1228.57 825.6,-1278.75 884.55,-1300.29"/>
+<polygon fill="black" stroke="black" points="883.68,-1303.7 894.27,-1303.85 886.08,-1297.13 883.68,-1303.7"/>
+</g>
+<!-- e_14_center&#45;&gt;cit_c -->
+<g id="edge78" class="edge">
+<title>e_14_center&#45;&gt;cit_c</title>
+<path fill="none" stroke="black" d="M657.42,-1218.34C648.96,-1217.82 626.98,-1216.66 608.64,-1217.46 531.74,-1220.86 441.4,-1230.33 396.58,-1235.4"/>
+<polygon fill="black" stroke="black" points="396,-1231.94 386.46,-1236.56 396.79,-1238.9 396,-1231.94"/>
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+<!-- o2_c -->
+<g id="node52" class="node">
+<title>o2_c</title>
+<ellipse fill="none" stroke="black" cx="558.29" cy="-1940.84" rx="18" ry="18"/>
+<text text-anchor="middle" x="558.29" y="-1937.14" font-family="Times,serif" font-size="14.00">o2_c</text>
+</g>
+<!-- o2_c&#45;&gt;e_15_center -->
+<g id="edge81" class="edge">
+<title>o2_c&#45;&gt;e_15_center</title>
+<path fill="none" stroke="black" d="M565.98,-1924.34C597.95,-1855.69 719.45,-1594.79 735.45,-1560.44"/>
+</g>
+<!-- q8h2_c -->
+<g id="node53" class="node">
+<title>q8h2_c</title>
+<ellipse fill="none" stroke="black" cx="795.16" cy="-1726.84" rx="18" ry="18"/>
+<text text-anchor="middle" x="795.16" y="-1723.14" font-family="Times,serif" font-size="14.00">q8h2_c</text>
+</g>
+<!-- q8h2_c&#45;&gt;e_15_center -->
+<g id="edge82" class="edge">
+<title>q8h2_c&#45;&gt;e_15_center</title>
+<path fill="none" stroke="black" d="M789.29,-1709.59C776.16,-1671.06 745.09,-1579.89 738.45,-1560.4"/>
+</g>
+<!-- e_43_center -->
+<g id="node104" class="node">
+<title>e_43_center</title>
+<polygon fill="none" stroke="black" points="720.64,-1865.62 713.64,-1865.62 713.64,-1858.62 720.64,-1858.62 720.64,-1865.62"/>
+</g>
+<!-- q8h2_c&#45;&gt;e_43_center -->
+<g id="edge130" class="edge">
+<title>q8h2_c&#45;&gt;e_43_center</title>
+<path fill="none" stroke="black" d="M786.06,-1742.62C768.05,-1773.85 728.79,-1841.92 719.26,-1858.45"/>
+</g>
+<!-- q8_c -->
+<g id="node54" class="node">
+<title>q8_c</title>
+<ellipse fill="none" stroke="black" cx="845.94" cy="-1731.79" rx="18" ry="18"/>
+<text text-anchor="middle" x="845.94" y="-1728.09" font-family="Times,serif" font-size="14.00">q8_c</text>
+</g>
+<!-- q8_c&#45;&gt;e_66_center -->
+<g id="edge239" class="edge">
+<title>q8_c&#45;&gt;e_66_center</title>
+<path fill="none" stroke="black" d="M853.61,-1715.37C877.87,-1663.45 952.02,-1504.74 964.02,-1479.05"/>
+</g>
+<!-- e_88_center -->
+<g id="node150" class="node">
+<title>e_88_center</title>
+<polygon fill="none" stroke="black" points="763.01,-1882.78 756.01,-1882.78 756.01,-1875.78 763.01,-1875.78 763.01,-1882.78"/>
+</g>
+<!-- q8_c&#45;&gt;e_88_center -->
+<g id="edge321" class="edge">
+<title>q8_c&#45;&gt;e_88_center</title>
+<path fill="none" stroke="black" d="M831.85,-1743.51C825.45,-1749.33 818.12,-1756.74 812.72,-1764.4 784.85,-1803.92 765.58,-1860.36 760.72,-1875.45"/>
+</g>
+<!-- e_15_center&#45;&gt;h2o_c -->
+<g id="edge86" class="edge">
+<title>e_15_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="black" d="M737.1,-1553.03C736.27,-1518.45 729.79,-1249.23 727.65,-1160.49"/>
+<polygon fill="black" stroke="black" points="731.15,-1160.27 727.41,-1150.36 724.15,-1160.44 731.15,-1160.27"/>
+</g>
+<!-- e_15_center&#45;&gt;h_e -->
+<g id="edge85" class="edge">
+<title>e_15_center&#45;&gt;h_e</title>
+<path fill="none" stroke="black" d="M740.97,-1555.83C759.93,-1551.49 845.65,-1531.88 890.47,-1521.62"/>
+<polygon fill="black" stroke="black" points="891.44,-1524.99 900.41,-1519.35 889.88,-1518.16 891.44,-1524.99"/>
+</g>
+<!-- e_15_center&#45;&gt;q8_c -->
+<g id="edge84" class="edge">
+<title>e_15_center&#45;&gt;q8_c</title>
+<path fill="none" stroke="black" d="M739.46,-1560.36C751.11,-1579.11 804.64,-1665.3 831.08,-1707.87"/>
+<polygon fill="black" stroke="black" points="828.19,-1709.84 836.44,-1716.49 834.13,-1706.15 828.19,-1709.84"/>
+</g>
+<!-- lac__D_e -->
+<g id="node56" class="node">
+<title>lac__D_e</title>
+<ellipse fill="none" stroke="black" cx="1328.12" cy="-1933.24" rx="18" ry="18"/>
+<text text-anchor="middle" x="1328.12" y="-1929.54" font-family="Times,serif" font-size="14.00">lac__D_e</text>
+</g>
+<!-- lac__D_e&#45;&gt;e_16_center -->
+<g id="edge87" class="edge">
+<title>lac__D_e&#45;&gt;e_16_center</title>
+<path fill="none" stroke="black" d="M1317.78,-1918.07C1279.5,-1861.92 1147.06,-1667.62 1127.61,-1639.09"/>
+</g>
+<!-- e_32_target -->
+<g id="node83" class="node">
+<title>e_32_target</title>
+<ellipse fill="black" stroke="black" cx="1480.69" cy="-2153.52" rx="1.8" ry="1.8"/>
+</g>
+<!-- lac__D_e&#45;&gt;e_32_target -->
+<g id="edge111" class="edge">
+<title>lac__D_e&#45;&gt;e_32_target</title>
+<path fill="none" stroke="black" d="M1338.61,-1948.38C1367.77,-1990.49 1449.27,-2108.16 1473.69,-2143.42"/>
+<polygon fill="black" stroke="black" points="1470.9,-2145.54 1479.47,-2151.77 1476.65,-2141.55 1470.9,-2145.54"/>
+</g>
+<!-- lac__D_c -->
+<g id="node57" class="node">
+<title>lac__D_c</title>
+<ellipse fill="none" stroke="black" cx="1151.88" cy="-1489.97" rx="18" ry="18"/>
+<text text-anchor="middle" x="1151.88" y="-1486.27" font-family="Times,serif" font-size="14.00">lac__D_c</text>
+</g>
+<!-- lac__D_c&#45;&gt;e_60_center -->
+<g id="edge209" class="edge">
+<title>lac__D_c&#45;&gt;e_60_center</title>
+<path fill="none" stroke="black" d="M1141.63,-1474.72C1110.02,-1427.66 1015.11,-1286.36 998.32,-1261.35"/>
+</g>
+<!-- e_16_center&#45;&gt;h_c -->
+<g id="edge90" class="edge">
+<title>e_16_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1122.95,-1631.92C1108.63,-1608.77 1029.03,-1480.52 960.11,-1378.6 949.75,-1363.28 937.71,-1346.34 928.2,-1333.15"/>
+<polygon fill="black" stroke="black" points="930.76,-1330.72 922.06,-1324.67 925.09,-1334.82 930.76,-1330.72"/>
+</g>
+<!-- e_16_center&#45;&gt;lac__D_c -->
+<g id="edge89" class="edge">
+<title>e_16_center&#45;&gt;lac__D_c</title>
+<path fill="none" stroke="black" d="M1125.88,-1631.98C1128.71,-1616.52 1140,-1554.83 1146.74,-1518.03"/>
+<polygon fill="black" stroke="black" points="1150.23,-1518.4 1148.59,-1507.94 1143.34,-1517.14 1150.23,-1518.4"/>
+</g>
+<!-- 2pg_c -->
+<g id="node59" class="node">
+<title>2pg_c</title>
+<ellipse fill="none" stroke="black" cx="497.28" cy="-600.44" rx="18" ry="18"/>
+<text text-anchor="middle" x="497.28" y="-596.74" font-family="Times,serif" font-size="14.00">2pg_c</text>
+</g>
+<!-- 2pg_c&#45;&gt;3pg_c -->
+<g id="edge275" class="edge">
+<title>2pg_c&#45;&gt;3pg_c</title>
+<path fill="none" stroke="black" d="M513.85,-608.07C552.75,-625.99 650.17,-670.87 696.86,-692.38"/>
+<polygon fill="black" stroke="black" points="695.47,-695.59 706.02,-696.6 698.4,-689.24 695.47,-695.59"/>
+</g>
+<!-- e_17_center -->
+<g id="node60" class="node">
+<title>e_17_center</title>
+<polygon fill="none" stroke="black" points="571.44,-825.54 564.44,-825.54 564.44,-818.54 571.44,-818.54 571.44,-825.54"/>
+</g>
+<!-- 2pg_c&#45;&gt;e_17_center -->
+<g id="edge91" class="edge">
+<title>2pg_c&#45;&gt;e_17_center</title>
+<path fill="none" stroke="black" d="M502.82,-617.83C517.92,-665.17 559.14,-794.42 566.73,-818.24"/>
+</g>
+<!-- e_17_center&#45;&gt;h2o_c -->
+<g id="edge93" class="edge">
+<title>e_17_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="black" d="M569.97,-825.72C580.7,-845.2 631.92,-938.52 671.21,-1016.18 686.75,-1046.9 703.77,-1082.65 714.87,-1106.27"/>
+<polygon fill="black" stroke="black" points="711.83,-1108.02 719.24,-1115.59 718.17,-1105.05 711.83,-1108.02"/>
+</g>
+<!-- e_17_center&#45;&gt;pep_c -->
+<g id="edge92" class="edge">
+<title>e_17_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="black" d="M571.64,-822.19C590.04,-822.92 672.56,-826.18 716.78,-827.93"/>
+<polygon fill="black" stroke="black" points="716.75,-831.44 726.88,-828.33 717.03,-824.44 716.75,-831.44"/>
+</g>
+<!-- etoh_e -->
+<g id="node61" class="node">
+<title>etoh_e</title>
+<ellipse fill="none" stroke="black" cx="1127.45" cy="-2036.97" rx="18" ry="18"/>
+<text text-anchor="middle" x="1127.45" y="-2033.27" font-family="Times,serif" font-size="14.00">etoh_e</text>
+</g>
+<!-- etoh_e&#45;&gt;e_18_center -->
+<g id="edge95" class="edge">
+<title>etoh_e&#45;&gt;e_18_center</title>
+<path fill="none" stroke="black" d="M1124.92,-2019.03C1115.34,-1951.17 1081.63,-1712.31 1076.93,-1679.06"/>
+</g>
+<!-- e_23_target -->
+<g id="node67" class="node">
+<title>e_23_target</title>
+<ellipse fill="black" stroke="black" cx="1179.89" cy="-2295.78" rx="1.8" ry="1.8"/>
+</g>
+<!-- etoh_e&#45;&gt;e_23_target -->
+<g id="edge102" class="edge">
+<title>etoh_e&#45;&gt;e_23_target</title>
+<path fill="none" stroke="black" d="M1131.06,-2054.76C1141.08,-2104.22 1169.09,-2242.48 1177.48,-2283.9"/>
+<polygon fill="black" stroke="black" points="1174.05,-2284.61 1179.47,-2293.71 1180.92,-2283.22 1174.05,-2284.61"/>
+</g>
+<!-- e_18_center&#45;&gt;h_c -->
+<g id="edge97" class="edge">
+<title>e_18_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1075.35,-1671.52C1068.01,-1645.9 1022.63,-1491.92 960.11,-1378.6 951.09,-1362.25 938.92,-1345.14 929,-1332.1"/>
+<polygon fill="black" stroke="black" points="931.76,-1329.94 922.87,-1324.18 926.22,-1334.23 931.76,-1329.94"/>
+</g>
+<!-- e_18_center&#45;&gt;etoh_c -->
+<g id="edge96" class="edge">
+<title>e_18_center&#45;&gt;etoh_c</title>
+<path fill="none" stroke="black" d="M1080.1,-1674.12C1101.54,-1667.81 1210.59,-1635.74 1262.44,-1620.49"/>
+<polygon fill="black" stroke="black" points="1263.68,-1623.77 1272.29,-1617.59 1261.71,-1617.06 1263.68,-1623.77"/>
+</g>
+<!-- e_24_target -->
+<g id="node68" class="node">
+<title>e_24_target</title>
+<ellipse fill="black" stroke="black" cx="66.67" cy="-1786.44" rx="1.8" ry="1.8"/>
+</g>
+<!-- for_e -->
+<g id="node69" class="node">
+<title>for_e</title>
+<ellipse fill="none" stroke="black" cx="300.68" cy="-1655.94" rx="18" ry="18"/>
+<text text-anchor="middle" x="300.68" y="-1652.24" font-family="Times,serif" font-size="14.00">for_e</text>
+</g>
+<!-- for_e&#45;&gt;e_24_target -->
+<g id="edge103" class="edge">
+<title>for_e&#45;&gt;e_24_target</title>
+<path fill="none" stroke="black" d="M284.6,-1664.91C239.87,-1689.85 114.86,-1759.57 77.4,-1780.46"/>
+<polygon fill="black" stroke="black" points="75.56,-1777.48 68.53,-1785.4 78.97,-1783.59 75.56,-1777.48"/>
+</g>
+<!-- for_e&#45;&gt;e_41_center -->
+<g id="edge125" class="edge">
+<title>for_e&#45;&gt;e_41_center</title>
+<path fill="none" stroke="black" d="M317.42,-1648.91C378.31,-1623.3 586.09,-1535.94 616.6,-1523.11"/>
+</g>
+<!-- e_25_target -->
+<g id="node70" class="node">
+<title>e_25_target</title>
+<ellipse fill="black" stroke="black" cx="573.51" cy="-1.74" rx="1.8" ry="1.8"/>
+</g>
+<!-- fru_e -->
+<g id="node71" class="node">
+<title>fru_e</title>
+<ellipse fill="none" stroke="black" cx="639.15" cy="-248.46" rx="18" ry="18"/>
+<text text-anchor="middle" x="639.15" y="-244.76" font-family="Times,serif" font-size="14.00">fru_e</text>
+</g>
+<!-- fru_e&#45;&gt;e_25_target -->
+<g id="edge104" class="edge">
+<title>fru_e&#45;&gt;e_25_target</title>
+<path fill="none" stroke="black" d="M634.43,-230.71C621.75,-183.07 587.21,-53.24 576.63,-13.47"/>
+<polygon fill="black" stroke="black" points="579.98,-12.45 574.03,-3.69 573.21,-14.25 579.98,-12.45"/>
+</g>
+<!-- fru_e&#45;&gt;e_44_center -->
+<g id="edge134" class="edge">
+<title>fru_e&#45;&gt;e_44_center</title>
+<path fill="none" stroke="black" d="M644.05,-266.2C662.27,-332.13 725.48,-560.96 734.27,-592.81"/>
+</g>
+<!-- e_26_target -->
+<g id="node72" class="node">
+<title>e_26_target</title>
+<ellipse fill="black" stroke="black" cx="1276.35" cy="-2268.64" rx="1.8" ry="1.8"/>
+</g>
+<!-- fum_e -->
+<g id="node73" class="node">
+<title>fum_e</title>
+<ellipse fill="none" stroke="black" cx="1172.91" cy="-2025.98" rx="18" ry="18"/>
+<text text-anchor="middle" x="1172.91" y="-2022.28" font-family="Times,serif" font-size="14.00">fum_e</text>
+</g>
+<!-- fum_e&#45;&gt;e_26_target -->
+<g id="edge105" class="edge">
+<title>fum_e&#45;&gt;e_26_target</title>
+<path fill="none" stroke="black" d="M1180.02,-2042.66C1199.79,-2089.04 1255.05,-2218.67 1271.6,-2257.51"/>
+<polygon fill="black" stroke="black" points="1268.38,-2258.88 1275.52,-2266.71 1274.82,-2256.14 1268.38,-2258.88"/>
+</g>
+<!-- fum_e&#45;&gt;e_46_center -->
+<g id="edge142" class="edge">
+<title>fum_e&#45;&gt;e_46_center</title>
+<path fill="none" stroke="black" d="M1164.63,-2009.76C1133.43,-1948.65 1023.97,-1734.23 1007.89,-1702.74"/>
+</g>
+<!-- e_27_target -->
+<g id="node74" class="node">
+<title>e_27_target</title>
+<ellipse fill="black" stroke="black" cx="368.59" cy="-97.54" rx="1.8" ry="1.8"/>
+</g>
+<!-- glc__D_e -->
+<g id="node75" class="node">
+<title>glc__D_e</title>
+<ellipse fill="none" stroke="black" cx="497.17" cy="-318.79" rx="18" ry="18"/>
+<text text-anchor="middle" x="497.17" y="-315.09" font-family="Times,serif" font-size="14.00">glc__D_e</text>
+</g>
+<!-- glc__D_e&#45;&gt;e_27_target -->
+<g id="edge106" class="edge">
+<title>glc__D_e&#45;&gt;e_27_target</title>
+<path fill="none" stroke="black" d="M487.92,-302.88C463.09,-260.15 395.43,-143.73 374.7,-108.07"/>
+<polygon fill="black" stroke="black" points="377.66,-106.18 369.61,-99.29 371.6,-109.7 377.66,-106.18"/>
+</g>
+<!-- glc__D_e&#45;&gt;e_49_center -->
+<g id="edge156" class="edge">
+<title>glc__D_e&#45;&gt;e_49_center</title>
+<path fill="none" stroke="black" d="M506.27,-334.43C540.55,-393.36 660.83,-600.14 678.49,-630.51"/>
+</g>
+<!-- e_28_target -->
+<g id="node76" class="node">
+<title>e_28_target</title>
+<ellipse fill="black" stroke="black" cx="50.77" cy="-721.47" rx="1.8" ry="1.8"/>
+</g>
+<!-- gln__L_e -->
+<g id="node77" class="node">
+<title>gln__L_e</title>
+<ellipse fill="none" stroke="black" cx="285.16" cy="-852.78" rx="18" ry="18"/>
+<text text-anchor="middle" x="285.16" y="-849.08" font-family="Times,serif" font-size="14.00">gln__L_e</text>
+</g>
+<!-- gln__L_e&#45;&gt;e_28_target -->
+<g id="edge107" class="edge">
+<title>gln__L_e&#45;&gt;e_28_target</title>
+<path fill="none" stroke="black" d="M269.42,-843.96C224.96,-819.06 99.25,-748.63 61.57,-727.52"/>
+<polygon fill="black" stroke="black" points="63.08,-724.36 52.65,-722.53 59.66,-730.47 63.08,-724.36"/>
+</g>
+<!-- gln__L_e&#45;&gt;e_51_center -->
+<g id="edge168" class="edge">
+<title>gln__L_e&#45;&gt;e_51_center</title>
+<path fill="none" stroke="black" d="M301.05,-861.64C363.36,-896.36 589.05,-1022.16 620.49,-1039.67"/>
+</g>
+<!-- e_29_target -->
+<g id="node78" class="node">
+<title>e_29_target</title>
+<ellipse fill="black" stroke="black" cx="1800.55" cy="-1618.66" rx="1.8" ry="1.8"/>
+</g>
+<!-- glu__L_e -->
+<g id="node79" class="node">
+<title>glu__L_e</title>
+<ellipse fill="none" stroke="black" cx="1551.02" cy="-1527.4" rx="18" ry="18"/>
+<text text-anchor="middle" x="1551.02" y="-1523.7" font-family="Times,serif" font-size="14.00">glu__L_e</text>
+</g>
+<!-- glu__L_e&#45;&gt;e_29_target -->
+<g id="edge108" class="edge">
+<title>glu__L_e&#45;&gt;e_29_target</title>
+<path fill="none" stroke="black" d="M1568.17,-1533.67C1615.86,-1551.12 1749.16,-1599.87 1789.1,-1614.48"/>
+<polygon fill="black" stroke="black" points="1787.97,-1617.79 1798.56,-1617.94 1790.37,-1611.21 1787.97,-1617.79"/>
+</g>
+<!-- glu__L_e&#45;&gt;e_55_center -->
+<g id="edge192" class="edge">
+<title>glu__L_e&#45;&gt;e_55_center</title>
+<path fill="none" stroke="black" d="M1533.78,-1521.23C1469.7,-1498.28 1247.32,-1418.66 1216.37,-1407.57"/>
+</g>
+<!-- e_31_target -->
+<g id="node81" class="node">
+<title>e_31_target</title>
+<ellipse fill="black" stroke="black" cx="44.62" cy="-934.97" rx="1.8" ry="1.8"/>
+</g>
+<!-- h2o_e -->
+<g id="node82" class="node">
+<title>h2o_e</title>
+<ellipse fill="none" stroke="black" cx="313.99" cy="-1001.71" rx="18" ry="18"/>
+<text text-anchor="middle" x="313.99" y="-998.01" font-family="Times,serif" font-size="14.00">h2o_e</text>
+</g>
+<!-- h2o_e&#45;&gt;h2o_c -->
+<g id="edge200" class="edge">
+<title>h2o_e&#45;&gt;h2o_c</title>
+<path fill="none" stroke="black" d="M331.21,-1007.15C395.49,-1027.47 621.74,-1098.97 700.05,-1123.72"/>
+<polygon fill="black" stroke="black" points="699.09,-1127.08 709.68,-1126.76 701.2,-1120.41 699.09,-1127.08"/>
+</g>
+<!-- h2o_e&#45;&gt;e_31_target -->
+<g id="edge110" class="edge">
+<title>h2o_e&#45;&gt;e_31_target</title>
+<path fill="none" stroke="black" d="M296.32,-997.33C245.4,-984.72 99.32,-948.52 56.53,-937.92"/>
+<polygon fill="black" stroke="black" points="57.34,-934.52 46.79,-935.51 55.65,-941.31 57.34,-934.52"/>
+</g>
+<!-- e_33_target -->
+<g id="node84" class="node">
+<title>e_33_target</title>
+<ellipse fill="black" stroke="black" cx="1568.27" cy="-1997.95" rx="1.8" ry="1.8"/>
+</g>
+<!-- mal__L_e -->
+<g id="node85" class="node">
+<title>mal__L_e</title>
+<ellipse fill="none" stroke="black" cx="1379.92" cy="-1814.92" rx="18" ry="18"/>
+<text text-anchor="middle" x="1379.92" y="-1811.22" font-family="Times,serif" font-size="14.00">mal__L_e</text>
+</g>
+<!-- mal__L_e&#45;&gt;e_33_target -->
+<g id="edge112" class="edge">
+<title>mal__L_e&#45;&gt;e_33_target</title>
+<path fill="none" stroke="black" d="M1392.86,-1827.5C1428.71,-1862.33 1528.61,-1959.41 1559.23,-1989.17"/>
+<polygon fill="black" stroke="black" points="1557.16,-1992.03 1566.77,-1996.49 1562.04,-1987.01 1557.16,-1992.03"/>
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+<!-- mal__L_e&#45;&gt;e_62_center -->
+<g id="edge221" class="edge">
+<title>mal__L_e&#45;&gt;e_62_center</title>
+<path fill="none" stroke="black" d="M1367,-1802.17C1318.75,-1754.54 1150.46,-1588.44 1123.17,-1561.51"/>
+</g>
+<!-- e_34_target -->
+<g id="node86" class="node">
+<title>e_34_target</title>
+<ellipse fill="black" stroke="black" cx="1865.81" cy="-666.02" rx="1.8" ry="1.8"/>
+</g>
+<!-- nh4_e -->
+<g id="node87" class="node">
+<title>nh4_e</title>
+<ellipse fill="none" stroke="black" cx="1628.87" cy="-770.95" rx="18" ry="18"/>
+<text text-anchor="middle" x="1628.87" y="-767.25" font-family="Times,serif" font-size="14.00">nh4_e</text>
+</g>
+<!-- nh4_e&#45;&gt;e_34_target -->
+<g id="edge113" class="edge">
+<title>nh4_e&#45;&gt;e_34_target</title>
+<path fill="none" stroke="black" d="M1645.53,-763.57C1690.96,-743.45 1816.13,-688.02 1854.49,-671.03"/>
+<polygon fill="black" stroke="black" points="1856.2,-674.1 1863.93,-666.85 1853.37,-667.7 1856.2,-674.1"/>
+</g>
+<!-- nh4_c -->
+<g id="node114" class="node">
+<title>nh4_c</title>
+<ellipse fill="none" stroke="black" cx="1259.89" cy="-927.4" rx="18" ry="18"/>
+<text text-anchor="middle" x="1259.89" y="-923.7" font-family="Times,serif" font-size="14.00">nh4_c</text>
+</g>
+<!-- nh4_e&#45;&gt;nh4_c -->
+<g id="edge249" class="edge">
+<title>nh4_e&#45;&gt;nh4_c</title>
+<path fill="none" stroke="black" d="M1612.06,-778.08C1553.47,-802.92 1357.99,-885.81 1286.43,-916.15"/>
+<polygon fill="black" stroke="black" points="1284.64,-913.11 1276.8,-920.23 1287.37,-919.55 1284.64,-913.11"/>
+</g>
+<!-- e_35_target -->
+<g id="node88" class="node">
+<title>e_35_target</title>
+<ellipse fill="black" stroke="black" cx="299.66" cy="-2500.92" rx="1.8" ry="1.8"/>
+</g>
+<!-- o2_e -->
+<g id="node89" class="node">
+<title>o2_e</title>
+<ellipse fill="none" stroke="black" cx="405.25" cy="-2275.53" rx="18" ry="18"/>
+<text text-anchor="middle" x="405.25" y="-2271.83" font-family="Times,serif" font-size="14.00">o2_e</text>
+</g>
+<!-- o2_e&#45;&gt;o2_c -->
+<g id="edge250" class="edge">
+<title>o2_e&#45;&gt;o2_c</title>
+<path fill="none" stroke="black" d="M412.84,-2258.94C437.62,-2204.74 516.31,-2032.65 546.42,-1966.81"/>
+<polygon fill="black" stroke="black" points="549.68,-1968.09 550.66,-1957.54 543.32,-1965.18 549.68,-1968.09"/>
+</g>
+<!-- o2_e&#45;&gt;e_35_target -->
+<g id="edge114" class="edge">
+<title>o2_e&#45;&gt;e_35_target</title>
+<path fill="none" stroke="black" d="M397.49,-2292.11C377.04,-2335.76 322.09,-2453.05 304.89,-2489.77"/>
+<polygon fill="black" stroke="black" points="301.57,-2488.61 300.49,-2499.15 307.91,-2491.58 301.57,-2488.61"/>
+</g>
+<!-- e_36_target -->
+<g id="node90" class="node">
+<title>e_36_target</title>
+<ellipse fill="black" stroke="black" cx="191.03" cy="-1872.16" rx="1.8" ry="1.8"/>
+</g>
+<!-- pi_e -->
+<g id="node91" class="node">
+<title>pi_e</title>
+<ellipse fill="none" stroke="black" cx="399.26" cy="-1694.73" rx="18" ry="18"/>
+<text text-anchor="middle" x="399.26" y="-1691.03" font-family="Times,serif" font-size="14.00">pi_e</text>
+</g>
+<!-- pi_e&#45;&gt;e_36_target -->
+<g id="edge115" class="edge">
+<title>pi_e&#45;&gt;e_36_target</title>
+<path fill="none" stroke="black" d="M385.27,-1706.65C345.78,-1740.3 234.1,-1835.46 200.62,-1863.98"/>
+<polygon fill="black" stroke="black" points="198.04,-1861.59 192.69,-1870.74 202.58,-1866.92 198.04,-1861.59"/>
+</g>
+<!-- pi_e&#45;&gt;e_77_center -->
+<g id="edge277" class="edge">
+<title>pi_e&#45;&gt;e_77_center</title>
+<path fill="none" stroke="black" d="M412.85,-1682.62C464.74,-1636.37 648.88,-1472.27 677.33,-1446.92"/>
+</g>
+<!-- e_37_target -->
+<g id="node92" class="node">
+<title>e_37_target</title>
+<ellipse fill="black" stroke="black" cx="1.92" cy="-1481.45" rx="1.8" ry="1.8"/>
+</g>
+<!-- pyr_e -->
+<g id="node93" class="node">
+<title>pyr_e</title>
+<ellipse fill="none" stroke="black" cx="271.08" cy="-1416.72" rx="18" ry="18"/>
+<text text-anchor="middle" x="271.08" y="-1413.02" font-family="Times,serif" font-size="14.00">pyr_e</text>
+</g>
+<!-- pyr_e&#45;&gt;e_37_target -->
+<g id="edge116" class="edge">
+<title>pyr_e&#45;&gt;e_37_target</title>
+<path fill="none" stroke="black" d="M253.42,-1420.96C202.54,-1433.2 56.57,-1468.31 13.82,-1478.59"/>
+<polygon fill="black" stroke="black" points="12.99,-1475.19 4.08,-1480.93 14.63,-1481.99 12.99,-1475.19"/>
+</g>
+<!-- pyr_e&#45;&gt;e_83_center -->
+<g id="edge307" class="edge">
+<title>pyr_e&#45;&gt;e_83_center</title>
+<path fill="none" stroke="black" d="M288.58,-1412.19C357.44,-1394.35 607.64,-1329.53 640.57,-1321"/>
+</g>
+<!-- e_38_target -->
+<g id="node94" class="node">
+<title>e_38_target</title>
+<ellipse fill="black" stroke="black" cx="867.98" cy="-2203.58" rx="1.8" ry="1.8"/>
+</g>
+<!-- succ_e -->
+<g id="node95" class="node">
+<title>succ_e</title>
+<ellipse fill="none" stroke="black" cx="880.7" cy="-1935.02" rx="18" ry="18"/>
+<text text-anchor="middle" x="880.7" y="-1931.32" font-family="Times,serif" font-size="14.00">succ_e</text>
+</g>
+<!-- succ_e&#45;&gt;e_38_target -->
+<g id="edge117" class="edge">
+<title>succ_e&#45;&gt;e_38_target</title>
+<path fill="none" stroke="black" d="M879.84,-1953.05C877.43,-2003.99 870.61,-2148.03 868.56,-2191.2"/>
+<polygon fill="black" stroke="black" points="865.06,-2191.27 868.08,-2201.43 872.05,-2191.6 865.06,-2191.27"/>
+</g>
+<!-- succ_e&#45;&gt;e_86_center -->
+<g id="edge313" class="edge">
+<title>succ_e&#45;&gt;e_86_center</title>
+<path fill="none" stroke="black" d="M879.79,-1916.92C876.86,-1858.56 867.78,-1677.39 866.37,-1649.44"/>
+</g>
+<!-- fdp_c -->
+<g id="node96" class="node">
+<title>fdp_c</title>
+<ellipse fill="none" stroke="black" cx="837.15" cy="-608.74" rx="18" ry="18"/>
+<text text-anchor="middle" x="837.15" y="-605.04" font-family="Times,serif" font-size="14.00">fdp_c</text>
+</g>
+<!-- e_39_center -->
+<g id="node98" class="node">
+<title>e_39_center</title>
+<polygon fill="none" stroke="black" points="934.69,-385.26 927.69,-385.26 927.69,-378.26 934.69,-378.26 934.69,-385.26"/>
+</g>
+<!-- fdp_c&#45;&gt;e_39_center -->
+<g id="edge118" class="edge">
+<title>fdp_c&#45;&gt;e_39_center</title>
+<path fill="none" stroke="black" d="M844.07,-592.05C863.83,-544.34 919.79,-409.28 929.69,-385.39"/>
+</g>
+<!-- fdp_c&#45;&gt;e_40_center -->
+<g id="edge122" class="edge">
+<title>fdp_c&#45;&gt;e_40_center</title>
+<path fill="none" stroke="black" d="M833.1,-626.48C828.2,-648.05 819.77,-685.58 813.03,-717.87 803.8,-762.13 793.58,-816.1 790.89,-830.41"/>
+</g>
+<!-- dhap_c -->
+<g id="node97" class="node">
+<title>dhap_c</title>
+<ellipse fill="none" stroke="black" cx="1017.71" cy="-277.36" rx="18" ry="18"/>
+<text text-anchor="middle" x="1017.71" y="-273.66" font-family="Times,serif" font-size="14.00">dhap_c</text>
+</g>
+<!-- dhap_c&#45;&gt;g3p_c -->
+<g id="edge349" class="edge">
+<title>dhap_c&#45;&gt;g3p_c</title>
+<path fill="none" stroke="black" d="M1017.94,-295.45C1018.56,-346.26 1020.35,-490.66 1021.11,-552.4"/>
+<polygon fill="black" stroke="black" points="1017.61,-552.63 1021.24,-562.59 1024.61,-552.54 1017.61,-552.63"/>
+</g>
+<!-- e_39_center&#45;&gt;g3p_c -->
+<g id="edge120" class="edge">
+<title>e_39_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="black" d="M932.92,-385.56C942.33,-406.35 987.96,-507.04 1009.79,-555.2"/>
+<polygon fill="black" stroke="black" points="1006.62,-556.69 1013.94,-564.36 1013,-553.8 1006.62,-556.69"/>
+</g>
+<!-- e_39_center&#45;&gt;dhap_c -->
+<g id="edge119" class="edge">
+<title>e_39_center&#45;&gt;dhap_c</title>
+<path fill="none" stroke="black" d="M934.48,-377.8C945.01,-365.09 978.45,-324.74 999.6,-299.22"/>
+<polygon fill="black" stroke="black" points="1002.31,-301.44 1005.99,-291.51 996.92,-296.97 1002.31,-301.44"/>
+</g>
+<!-- e_40_center&#45;&gt;pi_c -->
+<g id="edge124" class="edge">
+<title>e_40_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" d="M789.55,-837.56C785.85,-857.98 767.74,-962.88 770.71,-1049.04 771.02,-1057.98 771.61,-1067.72 772.23,-1076.5"/>
+<polygon fill="black" stroke="black" points="768.75,-1076.93 772.99,-1086.64 775.73,-1076.41 768.75,-1076.93"/>
+</g>
+<!-- e_40_center&#45;&gt;f6p_c -->
+<g id="edge123" class="edge">
+<title>e_40_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" d="M792.97,-830.5C808.25,-810.98 882.95,-715.51 917.43,-671.46"/>
+<polygon fill="black" stroke="black" points="920.35,-673.41 923.76,-663.37 914.84,-669.09 920.35,-673.41"/>
+</g>
+<!-- for_c -->
+<g id="node100" class="node">
+<title>for_c</title>
+<ellipse fill="none" stroke="black" cx="426.89" cy="-1463.4" rx="18" ry="18"/>
+<text text-anchor="middle" x="426.89" y="-1459.7" font-family="Times,serif" font-size="14.00">for_c</text>
+</g>
+<!-- for_c&#45;&gt;for_e -->
+<g id="edge129" class="edge">
+<title>for_c&#45;&gt;for_e</title>
+<path fill="none" stroke="black" d="M416.99,-1478.51C395.11,-1511.89 342.51,-1592.13 316.21,-1632.26"/>
+<polygon fill="black" stroke="black" points="313.27,-1630.36 310.72,-1640.64 319.13,-1634.19 313.27,-1630.36"/>
+</g>
+<!-- e_41_center&#45;&gt;h_c -->
+<g id="edge128" class="edge">
+<title>e_41_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M624.03,-1518.86C651.49,-1498.91 825.15,-1372.77 888.41,-1326.83"/>
+<polygon fill="black" stroke="black" points="890.54,-1329.6 896.57,-1320.9 886.42,-1323.94 890.54,-1329.6"/>
+</g>
+<!-- e_41_center&#45;&gt;for_c -->
+<g id="edge127" class="edge">
+<title>e_41_center&#45;&gt;for_c</title>
+<path fill="none" stroke="black" d="M616.66,-1520.42C596.75,-1514.44 501.37,-1485.78 453.88,-1471.51"/>
+<polygon fill="black" stroke="black" points="454.83,-1468.14 444.25,-1468.61 452.82,-1474.84 454.83,-1468.14"/>
+</g>
+<!-- fum_c -->
+<g id="node102" class="node">
+<title>fum_c</title>
+<ellipse fill="none" stroke="black" cx="826.44" cy="-1778.39" rx="18" ry="18"/>
+<text text-anchor="middle" x="826.44" y="-1774.69" font-family="Times,serif" font-size="14.00">fum_c</text>
+</g>
+<!-- fum_c&#45;&gt;e_43_center -->
+<g id="edge131" class="edge">
+<title>fum_c&#45;&gt;e_43_center</title>
+<path fill="none" stroke="black" d="M812.15,-1789.34C786.69,-1808.84 734.82,-1848.57 720.74,-1859.36"/>
+</g>
+<!-- fum_c&#45;&gt;e_45_center -->
+<g id="edge139" class="edge">
+<title>fum_c&#45;&gt;e_45_center</title>
+<path fill="none" stroke="black" d="M825.09,-1760.43C820.48,-1699.33 805.58,-1501.7 803.39,-1472.7"/>
+</g>
+<!-- succ_c -->
+<g id="node103" class="node">
+<title>succ_c</title>
+<ellipse fill="none" stroke="black" cx="717.27" cy="-1656.99" rx="18" ry="18"/>
+<text text-anchor="middle" x="717.27" y="-1653.29" font-family="Times,serif" font-size="14.00">succ_c</text>
+</g>
+<!-- succ_c&#45;&gt;e_87_center -->
+<g id="edge318" class="edge">
+<title>succ_c&#45;&gt;e_87_center</title>
+<path fill="none" stroke="black" d="M735.49,-1656.71C764.56,-1656.22 823.22,-1654.99 872.89,-1652.5 880.11,-1652.14 888.53,-1651.49 893.28,-1651.1"/>
+</g>
+<!-- succ_c&#45;&gt;e_88_center -->
+<g id="edge322" class="edge">
+<title>succ_c&#45;&gt;e_88_center</title>
+<path fill="none" stroke="black" d="M720.66,-1674.8C729.74,-1722.61 754.27,-1851.7 758.79,-1875.49"/>
+</g>
+<!-- succ_c&#45;&gt;e_89_center -->
+<g id="edge327" class="edge">
+<title>succ_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="black" d="M718.63,-1638.82C723.69,-1571.27 741.26,-1336.88 743.7,-1304.25"/>
+</g>
+<!-- e_43_center&#45;&gt;q8_c -->
+<g id="edge132" class="edge">
+<title>e_43_center&#45;&gt;q8_c</title>
+<path fill="none" stroke="black" d="M720.76,-1858.36C733.36,-1845.3 776.5,-1800.68 812.72,-1764.4 816.86,-1760.25 821.32,-1755.84 825.58,-1751.64"/>
+<polygon fill="black" stroke="black" points="828.25,-1753.93 832.94,-1744.43 823.35,-1748.93 828.25,-1753.93"/>
+</g>
+<!-- e_43_center&#45;&gt;succ_c -->
+<g id="edge133" class="edge">
+<title>e_43_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" d="M717.14,-1858.56C717.15,-1838.24 717.22,-1736.05 717.25,-1685.45"/>
+<polygon fill="black" stroke="black" points="720.75,-1685.21 717.26,-1675.2 713.75,-1685.2 720.75,-1685.21"/>
+</g>
+<!-- e_44_center&#45;&gt;pyr_c -->
+<g id="edge137" class="edge">
+<title>e_44_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" d="M735.87,-600.28C740.88,-632.97 777,-868.68 789.53,-950.49"/>
+<polygon fill="black" stroke="black" points="786.1,-951.19 791.07,-960.55 793.02,-950.13 786.1,-951.19"/>
+</g>
+<!-- e_44_center&#45;&gt;f6p_c -->
+<g id="edge136" class="edge">
+<title>e_44_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" d="M739.14,-597.85C752.53,-602.5 798.42,-618.2 837.12,-628.34 860.61,-634.49 887.62,-640.12 907.3,-643.96"/>
+<polygon fill="black" stroke="black" points="906.65,-647.4 917.14,-645.85 907.98,-640.53 906.65,-647.4"/>
+</g>
+<!-- mal__L_c -->
+<g id="node106" class="node">
+<title>mal__L_c</title>
+<ellipse fill="none" stroke="black" cx="977.94" cy="-1337.39" rx="18" ry="18"/>
+<text text-anchor="middle" x="977.94" y="-1333.69" font-family="Times,serif" font-size="14.00">mal__L_c</text>
+</g>
+<!-- mal__L_c&#45;&gt;e_63_center -->
+<g id="edge224" class="edge">
+<title>mal__L_c&#45;&gt;e_63_center</title>
+<path fill="none" stroke="black" d="M973.32,-1319.85C966.03,-1292.09 952.26,-1239.72 948.53,-1225.54"/>
+</g>
+<!-- mal__L_c&#45;&gt;e_64_center -->
+<g id="edge229" class="edge">
+<title>mal__L_c&#45;&gt;e_64_center</title>
+<path fill="none" stroke="black" d="M979.24,-1319.2C981.57,-1287 986.68,-1217.85 991.77,-1159.54 993.4,-1140.77 995.67,-1118.32 996.56,-1109.68"/>
+</g>
+<!-- mal__L_c&#45;&gt;e_65_center -->
+<g id="edge234" class="edge">
+<title>mal__L_c&#45;&gt;e_65_center</title>
+<path fill="none" stroke="black" d="M979.62,-1319.39C981.4,-1301.82 984.59,-1274.36 989.06,-1250.85 1003.5,-1174.8 1030.21,-1083.82 1035.88,-1064.83"/>
+</g>
+<!-- e_45_center&#45;&gt;mal__L_c -->
+<g id="edge140" class="edge">
+<title>e_45_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" d="M806.78,-1466.39C825.68,-1452.14 913.18,-1386.19 955.24,-1354.5"/>
+<polygon fill="black" stroke="black" points="957.6,-1357.1 963.48,-1348.28 953.39,-1351.51 957.6,-1357.1"/>
+</g>
+<!-- e_46_center&#45;&gt;h_c -->
+<g id="edge143" class="edge">
+<title>e_46_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1004.87,-1695.25C997.65,-1670.03 954.43,-1517.94 926.62,-1392.38 922.66,-1374.52 918.92,-1354.32 916.14,-1338.41"/>
+<polygon fill="black" stroke="black" points="919.52,-1337.42 914.37,-1328.16 912.62,-1338.61 919.52,-1337.42"/>
+</g>
+<!-- e_46_center&#45;&gt;fum_c -->
+<g id="edge144" class="edge">
+<title>e_46_center&#45;&gt;fum_c</title>
+<path fill="none" stroke="black" d="M1002.17,-1700.53C983.12,-1708.97 896.25,-1747.46 852.21,-1766.98"/>
+<polygon fill="black" stroke="black" points="850.72,-1763.81 843,-1771.06 853.56,-1770.21 850.72,-1763.81"/>
+</g>
+<!-- 6pgl_c -->
+<g id="node109" class="node">
+<title>6pgl_c</title>
+<ellipse fill="none" stroke="black" cx="1228.21" cy="-853.67" rx="18" ry="18"/>
+<text text-anchor="middle" x="1228.21" y="-849.97" font-family="Times,serif" font-size="14.00">6pgl_c</text>
+</g>
+<!-- 6pgl_c&#45;&gt;e_75_center -->
+<g id="edge271" class="edge">
+<title>6pgl_c&#45;&gt;e_75_center</title>
+<path fill="none" stroke="black" d="M1218.24,-869.01C1203.41,-891.47 1174.23,-934.32 1145.99,-968.09 1123.44,-995.06 1092.72,-1024.37 1082.41,-1034.04"/>
+</g>
+<!-- e_47_center&#45;&gt;h_c -->
+<g id="edge148" class="edge">
+<title>e_47_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1067.48,-971.03C1062.11,-982.99 1044.57,-1022.11 1030.26,-1054.55 996.19,-1131.78 990.83,-1152.53 954.28,-1228.62 945.05,-1247.83 933.8,-1269.14 925.15,-1285.14"/>
+<polygon fill="black" stroke="black" points="921.84,-1283.9 920.14,-1294.36 927.99,-1287.25 921.84,-1283.9"/>
+</g>
+<!-- e_47_center&#45;&gt;nadph_c -->
+<g id="edge149" class="edge">
+<title>e_47_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" d="M1073.03,-969.38C1083.5,-974.76 1112.9,-989.86 1134.63,-1001.01"/>
+<polygon fill="black" stroke="black" points="1133.19,-1004.21 1143.69,-1005.67 1136.39,-997.98 1133.19,-1004.21"/>
+</g>
+<!-- e_47_center&#45;&gt;6pgl_c -->
+<g id="edge147" class="edge">
+<title>e_47_center&#45;&gt;6pgl_c</title>
+<path fill="none" stroke="black" d="M1072.74,-964.79C1090.13,-952.36 1165.77,-898.3 1204.77,-870.43"/>
+<polygon fill="black" stroke="black" points="1207.29,-872.93 1213.39,-864.26 1203.22,-867.23 1207.29,-872.93"/>
+</g>
+<!-- 13dpg_c -->
+<g id="node111" class="node">
+<title>13dpg_c</title>
+<ellipse fill="none" stroke="black" cx="832.63" cy="-717.99" rx="18" ry="18"/>
+<text text-anchor="middle" x="832.63" y="-714.29" font-family="Times,serif" font-size="14.00">13dpg_c</text>
+</g>
+<!-- e_48_center&#45;&gt;nadh_c -->
+<g id="edge154" class="edge">
+<title>e_48_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" d="M975.74,-955.83C982.53,-979.45 1021.69,-1115.59 1038.64,-1174.51"/>
+<polygon fill="black" stroke="black" points="1035.32,-1175.6 1041.44,-1184.24 1042.04,-1173.67 1035.32,-1175.6"/>
+</g>
+<!-- e_48_center&#45;&gt;h_c -->
+<g id="edge155" class="edge">
+<title>e_48_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M973.51,-955.98C969.78,-967.38 958.4,-1003.15 951.94,-1033.52 932.8,-1123.52 919.78,-1231.92 914.32,-1282.1"/>
+<polygon fill="black" stroke="black" points="910.82,-1281.86 913.24,-1292.18 917.78,-1282.61 910.82,-1281.86"/>
+</g>
+<!-- e_48_center&#45;&gt;13dpg_c -->
+<g id="edge153" class="edge">
+<title>e_48_center&#45;&gt;13dpg_c</title>
+<path fill="none" stroke="black" d="M972.49,-948.62C958.31,-925.23 880.27,-796.54 847.32,-742.21"/>
+<polygon fill="black" stroke="black" points="850.25,-740.29 842.08,-733.56 844.27,-743.92 850.25,-740.29"/>
+</g>
+<!-- e_49_center&#45;&gt;pyr_c -->
+<g id="edge159" class="edge">
+<title>e_49_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" d="M681.06,-637.83C683.45,-658.49 696.92,-764.21 731.02,-842.8 747.76,-881.37 768.47,-925.45 781.41,-952.6"/>
+<polygon fill="black" stroke="black" points="778.34,-954.28 785.81,-961.79 784.65,-951.26 778.34,-954.28"/>
+</g>
+<!-- e_49_center&#45;&gt;g6p_c -->
+<g id="edge158" class="edge">
+<title>e_49_center&#45;&gt;g6p_c</title>
+<path fill="none" stroke="black" d="M684.32,-635.69C702.22,-642.78 782.36,-674.76 846.58,-704.21 862.83,-711.67 880.8,-720.58 894.93,-727.74"/>
+<polygon fill="black" stroke="black" points="893.54,-730.96 904.04,-732.38 896.72,-724.72 893.54,-730.96"/>
+</g>
+<!-- nh4_c&#45;&gt;e_50_center -->
+<g id="edge162" class="edge">
+<title>nh4_c&#45;&gt;e_50_center</title>
+<path fill="none" stroke="black" d="M1242.83,-933.79C1184.08,-955.79 992.13,-1027.68 962.5,-1038.78"/>
+</g>
+<!-- e_50_center&#45;&gt;h_c -->
+<g id="edge163" class="edge">
+<title>e_50_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M957.97,-1044.04C953.47,-1069.78 927.36,-1218.95 916.33,-1282"/>
+<polygon fill="black" stroke="black" points="912.85,-1281.58 914.58,-1292.04 919.75,-1282.79 912.85,-1281.58"/>
+</g>
+<!-- e_50_center&#45;&gt;adp_c -->
+<g id="edge166" class="edge">
+<title>e_50_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" d="M954.88,-1039.14C944.45,-1036.17 914.23,-1027.84 888.59,-1023.48 838.54,-1014.98 779.52,-1010.05 745.39,-1007.69"/>
+<polygon fill="black" stroke="black" points="745.44,-1004.18 735.23,-1007.01 744.98,-1011.17 745.44,-1004.18"/>
+</g>
+<!-- e_50_center&#45;&gt;pi_c -->
+<g id="edge164" class="edge">
+<title>e_50_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" d="M955.13,-1041.45C936.32,-1048.03 846.69,-1079.41 801.18,-1095.34"/>
+<polygon fill="black" stroke="black" points="799.95,-1092.06 791.67,-1098.67 802.26,-1098.67 799.95,-1092.06"/>
+</g>
+<!-- e_50_center&#45;&gt;gln__L_c -->
+<g id="edge165" class="edge">
+<title>e_50_center&#45;&gt;gln__L_c</title>
+<path fill="none" stroke="black" d="M955.1,-1037.2C945.36,-1028.89 917.55,-1005.16 897.73,-988.25"/>
+<polygon fill="black" stroke="black" points="899.94,-985.53 890.06,-981.7 895.4,-990.86 899.94,-985.53"/>
+</g>
+<!-- e_51_center&#45;&gt;h_c -->
+<g id="edge170" class="edge">
+<title>e_51_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M626.98,-1045.51C637.61,-1059.57 676.13,-1109.64 713.1,-1146.07 772.33,-1204.43 850.23,-1264.62 888.37,-1293.15"/>
+<polygon fill="black" stroke="black" points="886.63,-1296.22 896.74,-1299.38 890.81,-1290.6 886.63,-1296.22"/>
+</g>
+<!-- e_51_center&#45;&gt;adp_c -->
+<g id="edge173" class="edge">
+<title>e_51_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" d="M627.64,-1041.08C635.57,-1039.61 655.44,-1035.59 671.21,-1029.58 678.19,-1026.93 685.49,-1023.5 692.15,-1020.08"/>
+<polygon fill="black" stroke="black" points="694.19,-1022.96 701.37,-1015.17 690.89,-1016.78 694.19,-1022.96"/>
+</g>
+<!-- e_51_center&#45;&gt;pi_c -->
+<g id="edge171" class="edge">
+<title>e_51_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" d="M627.85,-1043.26C644.25,-1050.13 711,-1078.06 748.56,-1093.78"/>
+<polygon fill="black" stroke="black" points="747.29,-1097.04 757.87,-1097.68 750,-1090.59 747.29,-1097.04"/>
+</g>
+<!-- e_51_center&#45;&gt;gln__L_c -->
+<g id="edge172" class="edge">
+<title>e_51_center&#45;&gt;gln__L_c</title>
+<path fill="none" stroke="black" d="M627.72,-1041.3C640.2,-1039.83 682.81,-1034.44 717.05,-1025.55 764.87,-1013.13 818.83,-992.92 850.06,-980.59"/>
+<polygon fill="black" stroke="black" points="851.37,-983.84 859.36,-976.88 848.78,-977.33 851.37,-983.84"/>
+</g>
+<!-- e_52_center&#45;&gt;h_c -->
+<g id="edge179" class="edge">
+<title>e_52_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1052.46,-1101.88C1045.24,-1112.84 1023.48,-1145.78 1005.17,-1172.94 978.22,-1212.9 946.5,-1259.15 927.73,-1286.44"/>
+<polygon fill="black" stroke="black" points="924.67,-1284.71 921.88,-1294.93 930.43,-1288.68 924.67,-1284.71"/>
+</g>
+<!-- e_52_center&#45;&gt;akg_c -->
+<g id="edge180" class="edge">
+<title>e_52_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="black" d="M1058.66,-1101.19C1071.86,-1112 1117.1,-1149.05 1144.73,-1171.68"/>
+<polygon fill="black" stroke="black" points="1142.73,-1174.57 1152.68,-1178.2 1147.16,-1169.16 1142.73,-1174.57"/>
+</g>
+<!-- e_52_center&#45;&gt;nadph_c -->
+<g id="edge178" class="edge">
+<title>e_52_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" d="M1058.92,-1094.94C1071.65,-1084.75 1111.96,-1052.48 1137.66,-1031.91"/>
+<polygon fill="black" stroke="black" points="1140.13,-1034.41 1145.75,-1025.43 1135.76,-1028.95 1140.13,-1034.41"/>
+</g>
+<!-- e_52_center&#45;&gt;nh4_c -->
+<g id="edge177" class="edge">
+<title>e_52_center&#45;&gt;nh4_c</title>
+<path fill="none" stroke="black" d="M1057.79,-1094.44C1068.46,-1080.83 1107.27,-1032.56 1146.2,-1000.1 1174.63,-976.39 1211.28,-954.25 1235.17,-940.78"/>
+<polygon fill="black" stroke="black" points="1236.92,-943.81 1243.96,-935.89 1233.52,-937.69 1236.92,-943.81"/>
+</g>
+<!-- e_53_center&#45;&gt;glu__L_c -->
+<g id="edge184" class="edge">
+<title>e_53_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" d="M1025.83,-977.02C1035.89,-984.95 1064.66,-1008.22 1085.57,-1030.63 1103.67,-1050.03 1121.96,-1074.13 1134.57,-1091.62"/>
+<polygon fill="black" stroke="black" points="1131.96,-1093.99 1140.61,-1100.11 1137.66,-1089.93 1131.96,-1093.99"/>
+</g>
+<!-- e_53_center&#45;&gt;nh4_c -->
+<g id="edge183" class="edge">
+<title>e_53_center&#45;&gt;nh4_c</title>
+<path fill="none" stroke="black" d="M1025.88,-972.39C1039.57,-965.9 1088.92,-943.38 1132.34,-934.55 1165.81,-927.74 1205.17,-926.54 1231.22,-926.66"/>
+<polygon fill="black" stroke="black" points="1231.47,-930.16 1241.51,-926.78 1231.55,-923.16 1231.47,-930.16"/>
+</g>
+<!-- e_54_center&#45;&gt;glu__L_c -->
+<g id="edge190" class="edge">
+<title>e_54_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" d="M1093.66,-1113.59C1099.42,-1113.75 1111.19,-1114.06 1122.57,-1114.36"/>
+<polygon fill="black" stroke="black" points="1122.63,-1117.87 1132.72,-1114.63 1122.82,-1110.87 1122.63,-1117.87"/>
+</g>
+<!-- e_54_center&#45;&gt;nadp_c -->
+<g id="edge189" class="edge">
+<title>e_54_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="black" d="M1093.96,-1111.62C1105.95,-1105.88 1142.76,-1088.28 1168.1,-1076.16"/>
+<polygon fill="black" stroke="black" points="1169.67,-1079.29 1177.18,-1071.82 1166.65,-1072.98 1169.67,-1079.29"/>
+</g>
+<!-- e_55_center&#45;&gt;h_c -->
+<g id="edge193" class="edge">
+<title>e_55_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1209.02,-1404.47C1187.29,-1394.02 1075.36,-1341.38 977.98,-1317.79 965.6,-1314.79 951.63,-1312.96 939.7,-1311.83"/>
+<polygon fill="black" stroke="black" points="939.67,-1308.32 929.42,-1310.99 939.1,-1315.3 939.67,-1308.32"/>
+</g>
+<!-- e_55_center&#45;&gt;glu__L_c -->
+<g id="edge194" class="edge">
+<title>e_55_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" d="M1212.7,-1402.65C1212.14,-1381.69 1208.27,-1274.19 1186.45,-1189.95 1184.78,-1183.49 1183.53,-1182.13 1180.81,-1176.05 1175.49,-1164.15 1169.19,-1151.17 1163.75,-1140.25"/>
+<polygon fill="black" stroke="black" points="1166.85,-1138.63 1159.24,-1131.27 1160.6,-1141.77 1166.85,-1138.63"/>
+</g>
+<!-- 6pgc_c -->
+<g id="node121" class="node">
+<title>6pgc_c</title>
+<ellipse fill="none" stroke="black" cx="1357.1" cy="-922.35" rx="18" ry="18"/>
+<text text-anchor="middle" x="1357.1" y="-918.65" font-family="Times,serif" font-size="14.00">6pgc_c</text>
+</g>
+<!-- 6pgc_c&#45;&gt;e_56_center -->
+<g id="edge196" class="edge">
+<title>6pgc_c&#45;&gt;e_56_center</title>
+<path fill="none" stroke="black" d="M1348.22,-906.39C1335.34,-883.24 1312.24,-841.72 1305.33,-829.31"/>
+</g>
+<!-- xu5p__D_c -->
+<g id="node147" class="node">
+<title>xu5p__D_c</title>
+<ellipse fill="none" stroke="black" cx="1309.8" cy="-319.98" rx="18" ry="18"/>
+<text text-anchor="middle" x="1309.8" y="-316.28" font-family="Times,serif" font-size="14.00">xu5p__D_c</text>
+</g>
+<!-- ru5p__D_c&#45;&gt;xu5p__D_c -->
+<g id="edge311" class="edge">
+<title>ru5p__D_c&#45;&gt;xu5p__D_c</title>
+<path fill="none" stroke="black" d="M1358.64,-524.38C1349.4,-485.68 1327.42,-393.7 1316.38,-347.48"/>
+<polygon fill="black" stroke="black" points="1319.73,-346.47 1314,-337.56 1312.92,-348.1 1319.73,-346.47"/>
+</g>
+<!-- e_56_center&#45;&gt;co2_c -->
+<g id="edge198" class="edge">
+<title>e_56_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" d="M1299.76,-828.4C1281.3,-842.25 1196.02,-906.26 1154.73,-937.25"/>
+<polygon fill="black" stroke="black" points="1152.53,-934.53 1146.63,-943.33 1156.73,-940.13 1152.53,-934.53"/>
+</g>
+<!-- e_56_center&#45;&gt;nadph_c -->
+<g id="edge199" class="edge">
+<title>e_56_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" d="M1300.6,-829.31C1285.47,-849.19 1211.46,-946.41 1177.31,-991.27"/>
+<polygon fill="black" stroke="black" points="1174.31,-989.43 1171.04,-999.5 1179.88,-993.67 1174.31,-989.43"/>
+</g>
+<!-- e_56_center&#45;&gt;ru5p__D_c -->
+<g id="edge197" class="edge">
+<title>e_56_center&#45;&gt;ru5p__D_c</title>
+<path fill="none" stroke="black" d="M1304.09,-822.13C1309.55,-796.14 1343.24,-635.78 1357.03,-570.14"/>
+<polygon fill="black" stroke="black" points="1360.5,-570.61 1359.14,-560.1 1353.65,-569.17 1360.5,-570.61"/>
+</g>
+<!-- e_58_center&#45;&gt;akg_c -->
+<g id="edge205" class="edge">
+<title>e_58_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="black" d="M1002.21,-1165.5C1015.25,-1163.07 1059.76,-1155.75 1095.81,-1161.76 1111.55,-1164.38 1128.19,-1170.73 1141.4,-1176.73"/>
+<polygon fill="black" stroke="black" points="1140.24,-1180.05 1150.77,-1181.18 1143.24,-1173.73 1140.24,-1180.05"/>
+</g>
+<!-- e_58_center&#45;&gt;co2_c -->
+<g id="edge203" class="edge">
+<title>e_58_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" d="M1000.85,-1162.43C1007.84,-1151.3 1029.01,-1117.96 1048.23,-1091.44 1063.97,-1069.72 1071.03,-1066.56 1085.57,-1044.03 1098.98,-1023.24 1111.74,-998.15 1120.51,-979.77"/>
+<polygon fill="black" stroke="black" points="1123.75,-981.11 1124.84,-970.57 1117.42,-978.13 1123.75,-981.11"/>
+</g>
+<!-- e_58_center&#45;&gt;nadph_c -->
+<g id="edge204" class="edge">
+<title>e_58_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" d="M1002.14,-1162.77C1020.21,-1145.75 1100.21,-1070.36 1138.9,-1033.91"/>
+<polygon fill="black" stroke="black" points="1141.61,-1036.16 1146.49,-1026.75 1136.81,-1031.06 1141.61,-1036.16"/>
+</g>
+<!-- glx_c -->
+<g id="node125" class="node">
+<title>glx_c</title>
+<ellipse fill="none" stroke="black" cx="518.83" cy="-1516.48" rx="18" ry="18"/>
+<text text-anchor="middle" x="518.83" y="-1512.78" font-family="Times,serif" font-size="14.00">glx_c</text>
+</g>
+<!-- glx_c&#45;&gt;e_61_center -->
+<g id="edge216" class="edge">
+<title>glx_c&#45;&gt;e_61_center</title>
+<path fill="none" stroke="black" d="M533.35,-1505.72C579.82,-1471.32 723.22,-1365.14 747.52,-1347.15"/>
+</g>
+<!-- e_59_center&#45;&gt;succ_c -->
+<g id="edge208" class="edge">
+<title>e_59_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" d="M543.26,-1615.01C561.86,-1619.5 645.75,-1639.73 689.9,-1650.39"/>
+<polygon fill="black" stroke="black" points="689.16,-1653.81 699.7,-1652.75 690.8,-1647 689.16,-1653.81"/>
+</g>
+<!-- e_59_center&#45;&gt;glx_c -->
+<g id="edge207" class="edge">
+<title>e_59_center&#45;&gt;glx_c</title>
+<path fill="none" stroke="black" d="M538.76,-1610.41C536.48,-1599.67 529.72,-1567.79 524.7,-1544.14"/>
+<polygon fill="black" stroke="black" points="528.1,-1543.33 522.6,-1534.27 521.26,-1544.78 528.1,-1543.33"/>
+</g>
+<!-- e_60_center&#45;&gt;nadh_c -->
+<g id="edge211" class="edge">
+<title>e_60_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" d="M999.09,-1253.88C1004.74,-1247.65 1016.64,-1234.54 1027.09,-1223.02"/>
+<polygon fill="black" stroke="black" points="1029.88,-1225.16 1034.01,-1215.4 1024.7,-1220.45 1029.88,-1225.16"/>
+</g>
+<!-- e_60_center&#45;&gt;h_c -->
+<g id="edge213" class="edge">
+<title>e_60_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M992.14,-1259.81C982.51,-1265.81 955.67,-1282.53 935.56,-1295.07"/>
+<polygon fill="black" stroke="black" points="933.52,-1292.21 926.88,-1300.47 937.22,-1298.16 933.52,-1292.21"/>
+</g>
+<!-- e_60_center&#45;&gt;pyr_c -->
+<g id="edge212" class="edge">
+<title>e_60_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" d="M993.21,-1254.02C974.23,-1227.79 854.7,-1062.55 810.34,-1001.23"/>
+<polygon fill="black" stroke="black" points="813.06,-999.02 804.36,-992.97 807.39,-1003.12 813.06,-999.02"/>
+</g>
+<!-- e_61_center&#45;&gt;coa_c -->
+<g id="edge218" class="edge">
+<title>e_61_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" d="M753.79,-1340.92C765.4,-1325.65 811,-1265.7 836.47,-1232.22"/>
+<polygon fill="black" stroke="black" points="839.51,-1234 842.78,-1223.92 833.94,-1229.76 839.51,-1234"/>
+</g>
+<!-- e_61_center&#45;&gt;h_c -->
+<g id="edge219" class="edge">
+<title>e_61_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M754.69,-1343.76C771.64,-1340.12 843.52,-1324.69 883.79,-1316.04"/>
+<polygon fill="black" stroke="black" points="884.73,-1319.42 893.77,-1313.9 883.26,-1312.58 884.73,-1319.42"/>
+</g>
+<!-- e_61_center&#45;&gt;mal__L_c -->
+<g id="edge217" class="edge">
+<title>e_61_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" d="M754.6,-1344.43C776.59,-1343.74 894.66,-1340.02 949.68,-1338.28"/>
+<polygon fill="black" stroke="black" points="949.91,-1341.78 959.8,-1337.96 949.69,-1334.78 949.91,-1341.78"/>
+</g>
+<!-- e_62_center&#45;&gt;h_c -->
+<g id="edge223" class="edge">
+<title>e_62_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1116.48,-1554.31C1096.14,-1530.09 975.83,-1386.82 929.55,-1331.71"/>
+<polygon fill="black" stroke="black" points="932.14,-1329.35 923.03,-1323.94 926.78,-1333.85 932.14,-1329.35"/>
+</g>
+<!-- e_62_center&#45;&gt;mal__L_c -->
+<g id="edge222" class="edge">
+<title>e_62_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" d="M1116.97,-1553.98C1102.32,-1531.17 1026.05,-1412.35 993.11,-1361.04"/>
+<polygon fill="black" stroke="black" points="996.02,-1359.08 987.67,-1352.56 990.13,-1362.86 996.02,-1359.08"/>
+</g>
+<!-- e_63_center&#45;&gt;nadh_c -->
+<g id="edge226" class="edge">
+<title>e_63_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" d="M951.33,-1221.15C962.21,-1218.92 994.49,-1212.32 1018.45,-1207.41"/>
+<polygon fill="black" stroke="black" points="1019.35,-1210.8 1028.44,-1205.37 1017.94,-1203.94 1019.35,-1210.8"/>
+</g>
+<!-- e_63_center&#45;&gt;h_c -->
+<g id="edge227" class="edge">
+<title>e_63_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M946.02,-1225.71C941.96,-1235.62 930.75,-1262.96 922.18,-1283.86"/>
+<polygon fill="black" stroke="black" points="918.9,-1282.63 918.34,-1293.21 925.38,-1285.29 918.9,-1282.63"/>
+</g>
+<!-- e_63_center&#45;&gt;oaa_c -->
+<g id="edge228" class="edge">
+<title>e_63_center&#45;&gt;oaa_c</title>
+<path fill="none" stroke="black" d="M944.9,-1218.3C931.95,-1200.78 875.3,-1124.17 846.61,-1085.38"/>
+<polygon fill="black" stroke="black" points="849.38,-1083.23 840.62,-1077.27 843.75,-1087.39 849.38,-1083.23"/>
+</g>
+<!-- e_64_center&#45;&gt;nadh_c -->
+<g id="edge232" class="edge">
+<title>e_64_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" d="M998.81,-1109.69C1004.4,-1120.48 1021.28,-1153.07 1033.36,-1176.39"/>
+<polygon fill="black" stroke="black" points="1030.33,-1178.15 1038.04,-1185.42 1036.54,-1174.93 1030.33,-1178.15"/>
+</g>
+<!-- e_64_center&#45;&gt;co2_c -->
+<g id="edge231" class="edge">
+<title>e_64_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" d="M998.94,-1102.37C1003.78,-1093.65 1016.67,-1071.23 1030.26,-1054.55 1055.45,-1023.64 1089.13,-992.03 1110.75,-972.74"/>
+<polygon fill="black" stroke="black" points="1113.23,-975.22 1118.4,-965.98 1108.59,-969.97 1113.23,-975.22"/>
+</g>
+<!-- e_64_center&#45;&gt;pyr_c -->
+<g id="edge233" class="edge">
+<title>e_64_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" d="M993.1,-1105.05C985.21,-1102.9 966.69,-1097.46 952.36,-1090.12 899.99,-1063.27 845.23,-1021.01 815.75,-996.88"/>
+<polygon fill="black" stroke="black" points="817.73,-993.97 807.79,-990.3 813.27,-999.37 817.73,-993.97"/>
+</g>
+<!-- e_65_center&#45;&gt;co2_c -->
+<g id="edge236" class="edge">
+<title>e_65_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" d="M1040.13,-1057.69C1051.36,-1045.06 1089.87,-1001.76 1113.38,-975.32"/>
+<polygon fill="black" stroke="black" points="1116.12,-977.51 1120.15,-967.71 1110.89,-972.86 1116.12,-977.51"/>
+</g>
+<!-- e_65_center&#45;&gt;nadph_c -->
+<g id="edge238" class="edge">
+<title>e_65_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" d="M1040.52,-1060.05C1048.57,-1057.31 1068.82,-1050.37 1085.57,-1044.03 1101.61,-1037.96 1119.43,-1030.79 1133.61,-1024.98"/>
+<polygon fill="black" stroke="black" points="1135.3,-1028.07 1143.22,-1021.03 1132.64,-1021.6 1135.3,-1028.07"/>
+</g>
+<!-- e_65_center&#45;&gt;pyr_c -->
+<g id="edge237" class="edge">
+<title>e_65_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" d="M1033.41,-1059.79C1023.02,-1055.54 991.73,-1042.87 965.34,-1033.52 914.83,-1015.64 855.12,-997 821.13,-986.62"/>
+<polygon fill="black" stroke="black" points="822.04,-983.23 811.45,-983.67 820,-989.93 822.04,-983.23"/>
+</g>
+<!-- e_66_center&#45;&gt;nad_c -->
+<g id="edge244" class="edge">
+<title>e_66_center&#45;&gt;nad_c</title>
+<path fill="none" stroke="black" d="M967.24,-1471.83C977.18,-1448.53 1032.41,-1319.38 1079.78,-1215.14 1080.98,-1212.48 1082.26,-1209.71 1083.54,-1206.96"/>
+<polygon fill="black" stroke="black" points="1086.75,-1208.35 1087.82,-1197.81 1080.41,-1205.38 1086.75,-1208.35"/>
+</g>
+<!-- e_66_center&#45;&gt;h_e -->
+<g id="edge243" class="edge">
+<title>e_66_center&#45;&gt;h_e</title>
+<path fill="none" stroke="black" d="M961.93,-1478.64C957.13,-1482.64 948.44,-1489.9 940.05,-1496.91"/>
+<polygon fill="black" stroke="black" points="937.66,-1494.34 932.23,-1503.43 942.15,-1499.71 937.66,-1494.34"/>
+</g>
+<!-- e_66_center&#45;&gt;q8h2_c -->
+<g id="edge242" class="edge">
+<title>e_66_center&#45;&gt;q8h2_c</title>
+<path fill="none" stroke="black" d="M963.42,-1479.2C958.05,-1487.96 944.03,-1510.68 931.74,-1529.28 889.57,-1593.1 837.7,-1666.9 811.69,-1703.61"/>
+<polygon fill="black" stroke="black" points="808.59,-1701.93 805.66,-1712.11 814.3,-1705.98 808.59,-1701.93"/>
+</g>
+<!-- e_67_center&#45;&gt;nadh_c -->
+<g id="edge248" class="edge">
+<title>e_67_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" d="M1274.88,-1136.09C1259.78,-1139.98 1199.83,-1155.96 1153.09,-1175.86 1127.42,-1186.79 1122.89,-1195.4 1095.54,-1200.96 1088.96,-1202.29 1081.79,-1202.87 1075.01,-1203.04"/>
+<polygon fill="black" stroke="black" points="1074.82,-1199.54 1064.81,-1203.01 1074.8,-1206.54 1074.82,-1199.54"/>
+</g>
+<!-- e_67_center&#45;&gt;nadp_c -->
+<g id="edge247" class="edge">
+<title>e_67_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="black" d="M1274.81,-1132.12C1264.71,-1123.65 1235.79,-1099.4 1215.34,-1082.25"/>
+<polygon fill="black" stroke="black" points="1217.35,-1079.37 1207.44,-1075.63 1212.85,-1084.73 1217.35,-1079.37"/>
+</g>
+<!-- e_70_center&#45;&gt;accoa_c -->
+<g id="edge254" class="edge">
+<title>e_70_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="black" d="M955.39,-1085.31C939.13,-1093.67 872.85,-1127.77 835.78,-1146.84"/>
+<polygon fill="black" stroke="black" points="833.89,-1143.88 826.6,-1151.56 837.09,-1150.1 833.89,-1143.88"/>
+</g>
+<!-- e_70_center&#45;&gt;nadh_c -->
+<g id="edge256" class="edge">
+<title>e_70_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" d="M961.77,-1087.09C971.89,-1100.78 1008,-1149.64 1029.66,-1178.95"/>
+<polygon fill="black" stroke="black" points="1026.86,-1181.05 1035.62,-1187.01 1032.49,-1176.89 1026.86,-1181.05"/>
+</g>
+<!-- e_70_center&#45;&gt;co2_c -->
+<g id="edge255" class="edge">
+<title>e_70_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" d="M962.68,-1080.72C981.36,-1066.77 1067.65,-1002.35 1109.43,-971.16"/>
+<polygon fill="black" stroke="black" points="1111.71,-973.82 1117.63,-965.04 1107.52,-968.21 1111.71,-973.82"/>
+</g>
+<!-- e_71_center&#45;&gt;h_c -->
+<g id="edge260" class="edge">
+<title>e_71_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M839.5,-904.98C845.39,-938.16 891.12,-1195.77 906.43,-1282.06"/>
+<polygon fill="black" stroke="black" points="903.03,-1282.92 908.23,-1292.16 909.92,-1281.7 903.03,-1282.92"/>
+</g>
+<!-- e_71_center&#45;&gt;adp_c -->
+<g id="edge261" class="edge">
+<title>e_71_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" d="M835.36,-904.46C821.39,-916.45 769.05,-961.37 738.89,-987.25"/>
+<polygon fill="black" stroke="black" points="736.34,-984.83 731.03,-994 740.89,-990.14 736.34,-984.83"/>
+</g>
+<!-- e_71_center&#45;&gt;fdp_c -->
+<g id="edge259" class="edge">
+<title>e_71_center&#45;&gt;fdp_c</title>
+<path fill="none" stroke="black" d="M839.44,-897.71C842.26,-878.67 854.56,-790.52 852.23,-718.11 851.33,-690.12 846.55,-658.46 842.61,-636.43"/>
+<polygon fill="black" stroke="black" points="846.02,-635.64 840.76,-626.45 839.14,-636.92 846.02,-635.64"/>
+</g>
+<!-- e_72_center&#45;&gt;accoa_c -->
+<g id="edge264" class="edge">
+<title>e_72_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="black" d="M619.06,-1222.94C639.18,-1216.31 735.75,-1184.49 783.51,-1168.76"/>
+<polygon fill="black" stroke="black" points="784.78,-1172.03 793.18,-1165.57 782.59,-1165.38 784.78,-1172.03"/>
+</g>
+<!-- e_72_center&#45;&gt;for_c -->
+<g id="edge265" class="edge">
+<title>e_72_center&#45;&gt;for_c</title>
+<path fill="none" stroke="black" d="M612.38,-1227.92C593.27,-1252.19 486.75,-1387.41 444.33,-1441.26"/>
+<polygon fill="black" stroke="black" points="441.53,-1439.16 438.09,-1449.18 447.03,-1443.49 441.53,-1439.16"/>
+</g>
+<!-- e_74_center&#45;&gt;adp_c -->
+<g id="edge270" class="edge">
+<title>e_74_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" d="M665.82,-811.12C671.22,-831.61 697.1,-929.96 709.9,-978.6"/>
+<polygon fill="black" stroke="black" points="706.57,-979.67 712.5,-988.45 713.34,-977.89 706.57,-979.67"/>
+</g>
+<!-- e_74_center&#45;&gt;13dpg_c -->
+<g id="edge269" class="edge">
+<title>e_74_center&#45;&gt;13dpg_c</title>
+<path fill="none" stroke="black" d="M668.33,-805.47C686.01,-796.05 766.23,-753.34 807.67,-731.28"/>
+<polygon fill="black" stroke="black" points="809.42,-734.31 816.6,-726.52 806.13,-728.13 809.42,-734.31"/>
+</g>
+<!-- e_75_center&#45;&gt;h_c -->
+<g id="edge273" class="edge">
+<title>e_75_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1076.75,-1040.98C1071.72,-1049.68 1058.7,-1072.31 1048.23,-1091.44 1028.57,-1127.38 1026.33,-1137.86 1005.17,-1172.94 980.27,-1214.21 947.93,-1260.05 928.47,-1286.91"/>
+<polygon fill="black" stroke="black" points="925.45,-1285.11 922.39,-1295.26 931.11,-1289.23 925.45,-1285.11"/>
+</g>
+<!-- e_75_center&#45;&gt;6pgc_c -->
+<g id="edge274" class="edge">
+<title>e_75_center&#45;&gt;6pgc_c</title>
+<path fill="none" stroke="black" d="M1082.44,-1035.15C1092.35,-1029.17 1121.14,-1012.08 1146.2,-1000.1 1210,-969.58 1289.16,-943.31 1329.96,-930.57"/>
+<polygon fill="black" stroke="black" points="1331.19,-933.85 1339.71,-927.55 1329.12,-927.16 1331.19,-933.85"/>
+</g>
+<!-- e_77_center&#45;&gt;h_c -->
+<g id="edge279" class="edge">
+<title>e_77_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M684.66,-1441.52C707.55,-1428.25 833.07,-1355.52 886.89,-1324.33"/>
+<polygon fill="black" stroke="black" points="888.87,-1327.22 895.77,-1319.18 885.36,-1321.17 888.87,-1327.22"/>
+</g>
+<!-- e_77_center&#45;&gt;pi_c -->
+<g id="edge278" class="edge">
+<title>e_77_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" d="M682.09,-1439.81C690.45,-1409.51 746.4,-1206.71 766.98,-1132.12"/>
+<polygon fill="black" stroke="black" points="770.46,-1132.65 769.75,-1122.08 763.71,-1130.79 770.46,-1132.65"/>
+</g>
+<!-- e_78_center&#45;&gt;h_c -->
+<g id="edge284" class="edge">
+<title>e_78_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M882.26,-1033.72C884.96,-1059.32 901.59,-1216.97 908.45,-1282.06"/>
+<polygon fill="black" stroke="black" points="904.98,-1282.45 909.51,-1292.03 911.94,-1281.71 904.98,-1282.45"/>
+</g>
+<!-- e_78_center&#45;&gt;pi_c -->
+<g id="edge283" class="edge">
+<title>e_78_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" d="M879.77,-1033.84C874.62,-1042.44 860.62,-1064.14 843.61,-1076.65 831.15,-1085.81 815.27,-1092.52 801.88,-1097.07"/>
+<polygon fill="black" stroke="black" points="800.69,-1093.78 792.22,-1100.14 802.81,-1100.45 800.69,-1093.78"/>
+</g>
+<!-- e_78_center&#45;&gt;oaa_c -->
+<g id="edge285" class="edge">
+<title>e_78_center&#45;&gt;oaa_c</title>
+<path fill="none" stroke="black" d="M878.15,-1032.52C872.99,-1035.74 863.27,-1041.82 853.89,-1047.67"/>
+<polygon fill="black" stroke="black" points="851.79,-1044.86 845.16,-1053.13 855.5,-1050.8 851.79,-1044.86"/>
+</g>
+<!-- e_79_center&#45;&gt;adp_c -->
+<g id="edge290" class="edge">
+<title>e_79_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" d="M868.93,-895.04C852,-907.41 778.44,-961.14 740.28,-989.02"/>
+<polygon fill="black" stroke="black" points="737.84,-986.47 731.83,-995.19 741.97,-992.12 737.84,-986.47"/>
+</g>
+<!-- e_79_center&#45;&gt;co2_c -->
+<g id="edge288" class="edge">
+<title>e_79_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" d="M876.14,-893.32C900.8,-899.18 1043.22,-933.01 1104.35,-947.53"/>
+<polygon fill="black" stroke="black" points="1103.9,-951.02 1114.44,-949.93 1105.52,-944.21 1103.9,-951.02"/>
+</g>
+<!-- e_79_center&#45;&gt;pep_c -->
+<g id="edge289" class="edge">
+<title>e_79_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="black" d="M868.79,-890.62C854.58,-883.56 802.49,-857.65 770.58,-841.78"/>
+<polygon fill="black" stroke="black" points="771.9,-838.53 761.39,-837.21 768.79,-844.8 771.9,-838.53"/>
+</g>
+<!-- e_80_center&#45;&gt;h_c -->
+<g id="edge296" class="edge">
+<title>e_80_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M667.63,-1026.51C691.04,-1053.74 839.59,-1226.56 892.63,-1288.26"/>
+<polygon fill="black" stroke="black" points="890.28,-1290.9 899.45,-1296.2 895.59,-1286.34 890.28,-1290.9"/>
+</g>
+<!-- e_80_center&#45;&gt;amp_c -->
+<g id="edge294" class="edge">
+<title>e_80_center&#45;&gt;amp_c</title>
+<path fill="none" stroke="black" d="M660.77,-1020.33C636.84,-1003.98 504.47,-913.55 449.93,-876.28"/>
+<polygon fill="black" stroke="black" points="451.81,-873.33 441.58,-870.58 447.86,-879.11 451.81,-873.33"/>
+</g>
+<!-- e_80_center&#45;&gt;pi_c -->
+<g id="edge297" class="edge">
+<title>e_80_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" d="M667.94,-1026.53C675.06,-1034 692.15,-1051.38 708.37,-1063.76 721.5,-1073.78 737.19,-1083.56 750,-1091.04"/>
+<polygon fill="black" stroke="black" points="748.32,-1094.12 758.74,-1096.06 751.81,-1088.05 748.32,-1094.12"/>
+</g>
+<!-- e_80_center&#45;&gt;pep_c -->
+<g id="edge295" class="edge">
+<title>e_80_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="black" d="M666.05,-1019.18C674.39,-999.1 714.56,-902.33 734.17,-855.1"/>
+<polygon fill="black" stroke="black" points="737.42,-856.39 738.02,-845.82 730.96,-853.71 737.42,-856.39"/>
+</g>
+<!-- e_81_center&#45;&gt;coa_c -->
+<g id="edge300" class="edge">
+<title>e_81_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" d="M595.5,-1131.02C620.5,-1138.59 765.38,-1182.46 826.61,-1201.01"/>
+<polygon fill="black" stroke="black" points="825.77,-1204.41 836.36,-1203.96 827.8,-1197.71 825.77,-1204.41"/>
+</g>
+<!-- e_81_center&#45;&gt;actp_c -->
+<g id="edge301" class="edge">
+<title>e_81_center&#45;&gt;actp_c</title>
+<path fill="none" stroke="black" d="M588.04,-1129.24C562.69,-1124.82 415.76,-1099.2 353.66,-1088.37"/>
+<polygon fill="black" stroke="black" points="354.23,-1084.92 343.77,-1086.65 353.02,-1091.81 354.23,-1084.92"/>
+</g>
+<!-- e_82_center&#45;&gt;atp_c -->
+<g id="edge305" class="edge">
+<title>e_82_center&#45;&gt;atp_c</title>
+<path fill="none" stroke="black" d="M773.8,-1042.84C768.87,-1043.53 759.6,-1044.81 750.27,-1046.11"/>
+<polygon fill="black" stroke="black" points="749.74,-1042.65 740.32,-1047.49 750.7,-1049.58 749.74,-1042.65"/>
+</g>
+<!-- e_82_center&#45;&gt;pyr_c -->
+<g id="edge306" class="edge">
+<title>e_82_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" d="M778.39,-1038.53C780.04,-1032.08 783.53,-1018.47 786.77,-1005.82"/>
+<polygon fill="black" stroke="black" points="790.18,-1006.6 789.28,-996.04 783.4,-1004.86 790.18,-1006.6"/>
+</g>
+<!-- e_83_center&#45;&gt;h_c -->
+<g id="edge310" class="edge">
+<title>e_83_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M647.93,-1319.93C673.31,-1318.98 819.84,-1313.53 882.74,-1311.18"/>
+<polygon fill="black" stroke="black" points="883.26,-1314.67 893.12,-1310.8 883,-1307.67 883.26,-1314.67"/>
+</g>
+<!-- e_83_center&#45;&gt;pyr_c -->
+<g id="edge309" class="edge">
+<title>e_83_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" d="M645.05,-1316.35C650.03,-1295.8 675.64,-1194.37 713.12,-1118.36 733.74,-1076.54 761.6,-1030.01 778.6,-1002.52"/>
+<polygon fill="black" stroke="black" points="781.61,-1004.3 783.92,-993.96 775.67,-1000.6 781.61,-1004.3"/>
+</g>
+<!-- xu5p__D_c&#45;&gt;e_92_center -->
+<g id="edge342" class="edge">
+<title>xu5p__D_c&#45;&gt;e_92_center</title>
+<path fill="none" stroke="black" d="M1293.37,-327.64C1264.17,-341.26 1204.89,-368.92 1189.66,-376.02"/>
+</g>
+<!-- xu5p__D_c&#45;&gt;e_93_center -->
+<g id="edge346" class="edge">
+<title>xu5p__D_c&#45;&gt;e_93_center</title>
+<path fill="none" stroke="black" d="M1294.8,-330.05C1254.9,-356.85 1147.74,-428.83 1126.38,-443.17"/>
+</g>
+<!-- e_86_center&#45;&gt;h_c -->
+<g id="edge316" class="edge">
+<title>e_86_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M866.7,-1642.03C870.72,-1612.17 897.55,-1413.02 907.61,-1338.33"/>
+<polygon fill="black" stroke="black" points="911.1,-1338.63 908.97,-1328.25 904.17,-1337.7 911.1,-1338.63"/>
+</g>
+<!-- e_86_center&#45;&gt;succ_c -->
+<g id="edge315" class="edge">
+<title>e_86_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" d="M862.51,-1646.08C846.65,-1647.27 783.28,-1652.03 745.68,-1654.85"/>
+<polygon fill="black" stroke="black" points="745.08,-1651.39 735.38,-1655.63 745.61,-1658.37 745.08,-1651.39"/>
+</g>
+<!-- e_87_center&#45;&gt;h_c -->
+<g id="edge320" class="edge">
+<title>e_87_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M897,-1647C896.86,-1631.02 896.47,-1567.41 898.38,-1515.18 900.7,-1451.96 906.06,-1377.93 909.14,-1338.4"/>
+<polygon fill="black" stroke="black" points="912.64,-1338.45 909.94,-1328.2 905.66,-1337.9 912.64,-1338.45"/>
+</g>
+<!-- e_87_center&#45;&gt;succ_e -->
+<g id="edge319" class="edge">
+<title>e_87_center&#45;&gt;succ_e</title>
+<path fill="none" stroke="black" d="M896.83,-1654.37C895.34,-1680.37 886.13,-1840.44 882.34,-1906.53"/>
+<polygon fill="black" stroke="black" points="878.83,-1906.46 881.75,-1916.65 885.82,-1906.87 878.83,-1906.46"/>
+</g>
+<!-- e_88_center&#45;&gt;q8h2_c -->
+<g id="edge323" class="edge">
+<title>e_88_center&#45;&gt;q8h2_c</title>
+<path fill="none" stroke="black" d="M760.39,-1875.51C764.23,-1859.09 779.73,-1792.83 788.69,-1754.54"/>
+<polygon fill="black" stroke="black" points="792.15,-1755.08 791.02,-1744.55 785.34,-1753.49 792.15,-1755.08"/>
+</g>
+<!-- e_88_center&#45;&gt;fum_c -->
+<g id="edge324" class="edge">
+<title>e_88_center&#45;&gt;fum_c</title>
+<path fill="none" stroke="black" d="M762.05,-1875.45C769.92,-1863.59 794.33,-1826.79 810.74,-1802.07"/>
+<polygon fill="black" stroke="black" points="813.76,-1803.84 816.37,-1793.58 807.93,-1799.97 813.76,-1803.84"/>
+</g>
+<!-- e_89_center&#45;&gt;adp_c -->
+<g id="edge330" class="edge">
+<title>e_89_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" d="M743.14,-1296.95C738.09,-1275.89 712.03,-1166.42 707.37,-1132.21 702.42,-1095.89 697.96,-1086.21 702.72,-1049.86 703.47,-1044.09 704.95,-1038.07 706.69,-1032.4"/>
+<polygon fill="black" stroke="black" points="710.08,-1033.3 709.98,-1022.7 703.45,-1031.04 710.08,-1033.3"/>
+</g>
+<!-- e_89_center&#45;&gt;succoa_c -->
+<g id="edge329" class="edge">
+<title>e_89_center&#45;&gt;succoa_c</title>
+<path fill="none" stroke="black" d="M747.49,-1302.06C767.81,-1311.3 871.11,-1358.27 920.22,-1380.6"/>
+<polygon fill="black" stroke="black" points="919,-1383.89 929.55,-1384.85 921.9,-1377.52 919,-1383.89"/>
+</g>
+<!-- e_89_center&#45;&gt;pi_c -->
+<g id="edge328" class="edge">
+<title>e_89_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" d="M744.57,-1296.73C747.7,-1276.68 762.65,-1180.92 770.18,-1132.63"/>
+<polygon fill="black" stroke="black" points="773.68,-1132.96 771.76,-1122.54 766.76,-1131.88 773.68,-1132.96"/>
+</g>
+<!-- s7p_c -->
+<g id="node152" class="node">
+<title>s7p_c</title>
+<ellipse fill="none" stroke="black" cx="1172.99" cy="-195.1" rx="18" ry="18"/>
+<text text-anchor="middle" x="1172.99" y="-191.4" font-family="Times,serif" font-size="14.00">s7p_c</text>
+</g>
+<!-- s7p_c&#45;&gt;e_90_center -->
+<g id="edge331" class="edge">
+<title>s7p_c&#45;&gt;e_90_center</title>
+<path fill="none" stroke="black" d="M1164.48,-211.18C1140.95,-255.61 1076.03,-378.24 1064.06,-400.84"/>
+</g>
+<!-- e_90_center&#45;&gt;e4p_c -->
+<g id="edge334" class="edge">
+<title>e_90_center&#45;&gt;e4p_c</title>
+<path fill="none" stroke="black" d="M1062.3,-408.04C1063.17,-428.66 1067.53,-532.7 1069.66,-583.55"/>
+<polygon fill="black" stroke="black" points="1066.17,-583.7 1070.08,-593.55 1073.16,-583.41 1066.17,-583.7"/>
+</g>
+<!-- e_90_center&#45;&gt;f6p_c -->
+<g id="edge333" class="edge">
+<title>e_90_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" d="M1060.15,-408.29C1047.45,-432.71 977.57,-567.08 948.07,-623.82"/>
+<polygon fill="black" stroke="black" points="944.88,-622.36 943.37,-632.85 951.09,-625.59 944.88,-622.36"/>
+</g>
+<!-- e_91_center&#45;&gt;nad_c -->
+<g id="edge340" class="edge">
+<title>e_91_center&#45;&gt;nad_c</title>
+<path fill="none" stroke="black" d="M1115.38,-1268.54C1113.09,-1258.41 1106.82,-1230.64 1101.96,-1209.14"/>
+<polygon fill="black" stroke="black" points="1105.33,-1208.17 1099.71,-1199.19 1098.5,-1209.72 1105.33,-1208.17"/>
+</g>
+<!-- e_91_center&#45;&gt;h_c -->
+<g id="edge339" class="edge">
+<title>e_91_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" d="M1112.71,-1273.1C1092.33,-1276.85 989.44,-1295.77 939.16,-1305.01"/>
+<polygon fill="black" stroke="black" points="938.48,-1301.58 929.27,-1306.83 939.74,-1308.46 938.48,-1301.58"/>
+</g>
+<!-- e_91_center&#45;&gt;nadph_c -->
+<g id="edge338" class="edge">
+<title>e_91_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" d="M1116.38,-1268.52C1116.96,-1250.67 1119.98,-1175.49 1131.34,-1115.06 1136.13,-1089.58 1144.44,-1061.23 1150.88,-1041.07"/>
+<polygon fill="black" stroke="black" points="1154.28,-1041.92 1154.04,-1031.33 1147.62,-1039.75 1154.28,-1041.92"/>
+</g>
+<!-- e_92_center&#45;&gt;g3p_c -->
+<g id="edge344" class="edge">
+<title>e_92_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="black" d="M1183.26,-381.5C1175.15,-392.54 1150.67,-425.67 1129.35,-452.38 1098.8,-490.64 1061.88,-534.06 1040.11,-559.39"/>
+<polygon fill="black" stroke="black" points="1037.21,-557.39 1033.34,-567.25 1042.52,-561.96 1037.21,-557.39"/>
+</g>
+<!-- e_92_center&#45;&gt;s7p_c -->
+<g id="edge343" class="edge">
+<title>e_92_center&#45;&gt;s7p_c</title>
+<path fill="none" stroke="black" d="M1185.76,-373.9C1184.39,-354.79 1178.24,-268.59 1175,-223.23"/>
+<polygon fill="black" stroke="black" points="1178.48,-222.88 1174.28,-213.16 1171.5,-223.38 1178.48,-222.88"/>
+</g>
+<!-- e_93_center&#45;&gt;g3p_c -->
+<g id="edge348" class="edge">
+<title>e_93_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="black" d="M1119.94,-449.3C1108.52,-464.57 1063.67,-524.52 1038.62,-558.01"/>
+<polygon fill="black" stroke="black" points="1035.61,-556.2 1032.42,-566.31 1041.21,-560.4 1035.61,-556.2"/>
+</g>
+<!-- e_93_center&#45;&gt;f6p_c -->
+<g id="edge347" class="edge">
+<title>e_93_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" d="M1119.03,-449.41C1104.73,-464.16 1050.84,-519.93 1007.72,-566.98 989.02,-587.38 968.11,-611.07 953.51,-627.74"/>
+<polygon fill="black" stroke="black" points="950.83,-625.49 946.89,-635.32 956.11,-630.1 950.83,-625.49"/>
+</g>
+</g>
+</svg>
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diff --git a/main/_images/66ec3dbd2d4149b75be0407118008cbd8c54d4d16f6cc666b9a7938a007211b1.svg b/main/_images/66ec3dbd2d4149b75be0407118008cbd8c54d4d16f6cc666b9a7938a007211b1.svg
new file mode 100644
index 00000000..e15b78e5
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+ -->
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+ viewBox="0.00 0.00 2169.00 2236.00" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
+<g id="graph0" class="graph" transform="scale(1 1) rotate(0) translate(4 2232)">
+<title>%3</title>
+<polygon fill="white" stroke="transparent" points="-4,4 -4,-2232 2165,-2232 2165,4 -4,4"/>
+<!-- coa_c -->
+<g id="node1" class="node">
+<title>coa_c</title>
+<ellipse fill="none" stroke="black" cx="1015" cy="-1106.52" rx="18" ry="18"/>
+<text text-anchor="middle" x="1015" y="-1102.82" font-family="Times,serif" font-size="14.00">coa_c</text>
+</g>
+<!-- e_0_center -->
+<g id="node7" class="node">
+<title>e_0_center</title>
+<polygon fill="none" stroke="black" points="1228.52,-1209.9 1221.52,-1209.9 1221.52,-1202.9 1228.52,-1202.9 1228.52,-1209.9"/>
+</g>
+<!-- coa_c&#45;&gt;e_0_center -->
+<g id="edge1" class="edge">
+<title>coa_c&#45;&gt;e_0_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1031.48,-1114.35C1076.35,-1135.69 1198.85,-1193.95 1221.42,-1204.68"/>
+</g>
+<!-- e_7_center -->
+<g id="node28" class="node">
+<title>e_7_center</title>
+<polygon fill="none" stroke="black" points="1205.03,-1100.88 1198.03,-1100.88 1198.03,-1093.88 1205.03,-1093.88 1205.03,-1100.88"/>
+</g>
+<!-- coa_c&#45;&gt;e_7_center -->
+<g id="edge25" class="edge">
+<title>coa_c&#45;&gt;e_7_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1033.03,-1108.93C1054.14,-1111.43 1090.17,-1114.74 1121.11,-1112.72 1151.18,-1110.76 1186.6,-1101.52 1197.89,-1098.41"/>
+</g>
+<!-- e_70_center -->
+<g id="node135" class="node">
+<title>e_70_center</title>
+<polygon fill="none" stroke="black" points="1201.34,-1000.02 1194.34,-1000.02 1194.34,-993.02 1201.34,-993.02 1201.34,-1000.02"/>
+</g>
+<!-- coa_c&#45;&gt;e_70_center -->
+<g id="edge251" class="edge">
+<title>coa_c&#45;&gt;e_70_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.7" d="M1032.12,-1100.68C1042.8,-1096.99 1056.79,-1092.05 1069.08,-1087.39 1075.32,-1085.02 1077.17,-1085.01 1082.98,-1081.74 1130.17,-1055.22 1180.28,-1012.06 1194.12,-999.84"/>
+</g>
+<!-- e_72_center -->
+<g id="node137" class="node">
+<title>e_72_center</title>
+<polygon fill="none" stroke="black" points="1284.92,-1123.9 1277.92,-1123.9 1277.92,-1116.9 1284.92,-1116.9 1284.92,-1123.9"/>
+</g>
+<!-- coa_c&#45;&gt;e_72_center -->
+<g id="edge262" class="edge">
+<title>coa_c&#45;&gt;e_72_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1033.02,-1107.63C1054.13,-1108.92 1090.15,-1111.07 1121.11,-1112.72 1183.44,-1116.03 1259.43,-1119.43 1277.46,-1120.23"/>
+</g>
+<!-- e_89_center -->
+<g id="node151" class="node">
+<title>e_89_center</title>
+<polygon fill="none" stroke="black" points="811.94,-1169.54 804.94,-1169.54 804.94,-1162.54 811.94,-1162.54 811.94,-1169.54"/>
+</g>
+<!-- coa_c&#45;&gt;e_89_center -->
+<g id="edge325" class="edge">
+<title>coa_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M997.38,-1111.59C952.31,-1124.58 834.73,-1158.46 812.2,-1164.96"/>
+</g>
+<!-- acald_c -->
+<g id="node2" class="node">
+<title>acald_c</title>
+<ellipse fill="none" stroke="black" cx="1557.48" cy="-1324.36" rx="18" ry="18"/>
+<text text-anchor="middle" x="1557.48" y="-1320.66" font-family="Times,serif" font-size="14.00">acald_c</text>
+</g>
+<!-- acald_c&#45;&gt;e_0_center -->
+<g id="edge2" class="edge">
+<title>acald_c&#45;&gt;e_0_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1540.07,-1318.18C1476.47,-1295.61 1258.82,-1218.39 1228.53,-1207.64"/>
+</g>
+<!-- nad_c -->
+<g id="node3" class="node">
+<title>nad_c</title>
+<ellipse fill="none" stroke="black" cx="1121.25" cy="-1093.12" rx="18" ry="18"/>
+<text text-anchor="middle" x="1121.25" y="-1089.42" font-family="Times,serif" font-size="14.00">nad_c</text>
+</g>
+<!-- nad_c&#45;&gt;e_0_center -->
+<g id="edge3" class="edge">
+<title>nad_c&#45;&gt;e_0_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1133.56,-1106.56C1157.18,-1132.35 1207.75,-1187.54 1221.5,-1202.56"/>
+</g>
+<!-- nad_c&#45;&gt;e_7_center -->
+<g id="edge27" class="edge">
+<title>nad_c&#45;&gt;e_7_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1139.47,-1094.09C1158.71,-1095.11 1187.66,-1096.64 1197.84,-1097.18"/>
+</g>
+<!-- e_9_center -->
+<g id="node32" class="node">
+<title>e_9_center</title>
+<polygon fill="none" stroke="black" points="1285.28,-1278.77 1278.28,-1278.77 1278.28,-1271.77 1285.28,-1271.77 1285.28,-1278.77"/>
+</g>
+<!-- nad_c&#45;&gt;e_9_center -->
+<g id="edge35" class="edge">
+<title>nad_c&#45;&gt;e_9_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1132.09,-1107.6C1149.52,-1130.6 1185.15,-1176.62 1218.32,-1213.1 1239.91,-1236.83 1268.31,-1263.05 1278.2,-1272.04"/>
+</g>
+<!-- e_12_center -->
+<g id="node49" class="node">
+<title>e_12_center</title>
+<polygon fill="none" stroke="black" points="991.78,-831.32 984.78,-831.32 984.78,-824.32 991.78,-824.32 991.78,-831.32"/>
+</g>
+<!-- nad_c&#45;&gt;e_12_center -->
+<g id="edge61" class="edge">
+<title>nad_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M1113.13,-1076.92C1086.63,-1024.05 1003.57,-858.33 990.12,-831.5"/>
+</g>
+<!-- e_48_center -->
+<g id="node112" class="node">
+<title>e_48_center</title>
+<polygon fill="none" stroke="black" points="1026.69,-850.79 1019.69,-850.79 1019.69,-843.79 1026.69,-843.79 1026.69,-850.79"/>
+</g>
+<!-- nad_c&#45;&gt;e_48_center -->
+<g id="edge151" class="edge">
+<title>nad_c&#45;&gt;e_48_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.27" d="M1114.51,-1076.22C1094.26,-1025.45 1034.73,-876.22 1024.65,-850.94"/>
+</g>
+<!-- e_60_center -->
+<g id="node127" class="node">
+<title>e_60_center</title>
+<polygon fill="none" stroke="black" points="1258.41,-1162.74 1251.41,-1162.74 1251.41,-1155.74 1258.41,-1155.74 1258.41,-1162.74"/>
+</g>
+<!-- nad_c&#45;&gt;e_60_center -->
+<g id="edge210" class="edge">
+<title>nad_c&#45;&gt;e_60_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1137.64,-1101.23C1168.87,-1116.67 1235.23,-1149.5 1251.33,-1157.47"/>
+</g>
+<!-- e_63_center -->
+<g id="node130" class="node">
+<title>e_63_center</title>
+<polygon fill="none" stroke="black" points="1078.31,-1175.09 1071.31,-1175.09 1071.31,-1168.09 1078.31,-1168.09 1078.31,-1175.09"/>
+</g>
+<!-- nad_c&#45;&gt;e_63_center -->
+<g id="edge224" class="edge">
+<title>nad_c&#45;&gt;e_63_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1112.07,-1108.62C1100.97,-1127.38 1083.01,-1157.74 1076.91,-1168.04"/>
+</g>
+<!-- e_64_center -->
+<g id="node131" class="node">
+<title>e_64_center</title>
+<polygon fill="none" stroke="black" points="1292.86,-1057.05 1285.86,-1057.05 1285.86,-1050.05 1292.86,-1050.05 1292.86,-1057.05"/>
+</g>
+<!-- nad_c&#45;&gt;e_64_center -->
+<g id="edge229" class="edge">
+<title>nad_c&#45;&gt;e_64_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1139.34,-1090.76C1147.33,-1089.6 1156.83,-1088.08 1165.32,-1086.3 1213.29,-1076.29 1270.42,-1059.3 1285.54,-1054.72"/>
+</g>
+<!-- e_67_center -->
+<g id="node134" class="node">
+<title>e_67_center</title>
+<polygon fill="none" stroke="black" points="1301.46,-958.49 1294.46,-958.49 1294.46,-951.49 1301.46,-951.49 1301.46,-958.49"/>
+</g>
+<!-- nad_c&#45;&gt;e_67_center -->
+<g id="edge245" class="edge">
+<title>nad_c&#45;&gt;e_67_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1131.09,-1077.58C1136.55,-1069.65 1143.79,-1060.15 1151.56,-1052.8 1201.3,-1005.75 1276.08,-966.15 1294,-956.98"/>
+</g>
+<!-- nad_c&#45;&gt;e_70_center -->
+<g id="edge253" class="edge">
+<title>nad_c&#45;&gt;e_70_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.7" d="M1132.04,-1078.45C1137.76,-1070.75 1144.95,-1061.2 1151.56,-1052.8 1167.51,-1032.52 1187.43,-1008.82 1194.86,-1000.03"/>
+</g>
+<!-- h_c -->
+<g id="node4" class="node">
+<title>h_c</title>
+<ellipse fill="none" stroke="black" cx="981.07" cy="-1185.75" rx="18" ry="18"/>
+<text text-anchor="middle" x="981.07" y="-1182.05" font-family="Times,serif" font-size="14.00">h_c</text>
+</g>
+<!-- e_15_center -->
+<g id="node55" class="node">
+<title>e_15_center</title>
+<polygon fill="none" stroke="black" points="745.45,-1389.39 738.45,-1389.39 738.45,-1382.39 745.45,-1382.39 745.45,-1389.39"/>
+</g>
+<!-- h_c&#45;&gt;e_15_center -->
+<g id="edge82" class="edge">
+<title>h_c&#45;&gt;e_15_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M967.81,-1198.61C943.2,-1222.26 888.53,-1273.92 839.49,-1314.03 804.32,-1342.79 759.06,-1374.18 745.78,-1383.28"/>
+</g>
+<!-- e_54_center -->
+<g id="node119" class="node">
+<title>e_54_center</title>
+<polygon fill="none" stroke="black" points="946.14,-960.68 939.14,-960.68 939.14,-953.68 946.14,-953.68 946.14,-960.68"/>
+</g>
+<!-- h_c&#45;&gt;e_54_center -->
+<g id="edge186" class="edge">
+<title>h_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M973.68,-1169.04C959.49,-1135.22 930.04,-1056 932.87,-986.74 933.27,-977.02 937.94,-966.35 940.68,-960.88"/>
+</g>
+<!-- e_66_center -->
+<g id="node133" class="node">
+<title>e_66_center</title>
+<polygon fill="none" stroke="black" points="976.82,-1345.78 969.82,-1345.78 969.82,-1338.78 976.82,-1338.78 976.82,-1345.78"/>
+</g>
+<!-- h_c&#45;&gt;e_66_center -->
+<g id="edge241" class="edge">
+<title>h_c&#45;&gt;e_66_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M980.17,-1204.01C978.36,-1240.47 974.41,-1320.32 973.51,-1338.53"/>
+</g>
+<!-- e_82_center -->
+<g id="node145" class="node">
+<title>e_82_center</title>
+<polygon fill="none" stroke="black" points="982,-897.39 975,-897.39 975,-890.39 982,-890.39 982,-897.39"/>
+</g>
+<!-- h_c&#45;&gt;e_82_center -->
+<g id="edge304" class="edge">
+<title>h_c&#45;&gt;e_82_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M980.42,-1167.55C979.21,-1131.62 976.78,-1049.03 977.28,-979.58 977.5,-947.74 978.21,-909.25 978.43,-897.48"/>
+</g>
+<!-- nadh_c -->
+<g id="node5" class="node">
+<title>nadh_c</title>
+<ellipse fill="none" stroke="black" cx="1165.38" cy="-1066.7" rx="18" ry="18"/>
+<text text-anchor="middle" x="1165.38" y="-1063" font-family="Times,serif" font-size="14.00">nadh_c</text>
+</g>
+<!-- nadh_c&#45;&gt;e_66_center -->
+<g id="edge240" class="edge">
+<title>nadh_c&#45;&gt;e_66_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1157.58,-1082.94C1149.42,-1099.62 1135.97,-1126.19 1122.77,-1148.26 1088.18,-1206.09 1079.69,-1221.07 1037.59,-1273.69 1016.39,-1300.2 987.21,-1328.91 977.01,-1338.75"/>
+</g>
+<!-- e_91_center -->
+<g id="node154" class="node">
+<title>e_91_center</title>
+<polygon fill="none" stroke="black" points="1119.57,-1145.06 1112.57,-1145.06 1112.57,-1138.06 1119.57,-1138.06 1119.57,-1145.06"/>
+</g>
+<!-- nadh_c&#45;&gt;e_91_center -->
+<g id="edge337" class="edge">
+<title>nadh_c&#45;&gt;e_91_center</title>
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+<!-- accoa_c -->
+<g id="node6" class="node">
+<title>accoa_c</title>
+<ellipse fill="none" stroke="black" cx="1022.87" cy="-1062.38" rx="18" ry="18"/>
+<text text-anchor="middle" x="1022.87" y="-1058.68" font-family="Times,serif" font-size="14.00">accoa_c</text>
+</g>
+<!-- accoa_c&#45;&gt;e_12_center -->
+<g id="edge55" class="edge">
+<title>accoa_c&#45;&gt;e_12_center</title>
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+<!-- e_14_center -->
+<g id="node51" class="node">
+<title>e_14_center</title>
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+<!-- accoa_c&#45;&gt;e_14_center -->
+<g id="edge76" class="edge">
+<title>accoa_c&#45;&gt;e_14_center</title>
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+<!-- e_61_center -->
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+<!-- accoa_c&#45;&gt;e_61_center -->
+<g id="edge216" class="edge">
+<title>accoa_c&#45;&gt;e_61_center</title>
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+</g>
+<!-- e_81_center -->
+<g id="node144" class="node">
+<title>e_81_center</title>
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+<!-- accoa_c&#45;&gt;e_81_center -->
+<g id="edge299" class="edge">
+<title>accoa_c&#45;&gt;e_81_center</title>
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+</g>
+<!-- e_0_center&#45;&gt;h_c -->
+<g id="edge4" class="edge">
+<title>e_0_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1221.19,-1206.07C1197.27,-1204.05 1067.61,-1193.08 1009.39,-1188.15"/>
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+<!-- e_0_center&#45;&gt;nadh_c -->
+<g id="edge5" class="edge">
+<title>e_0_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1223.43,-1202.66C1216.85,-1187.26 1191.49,-1127.87 1176.55,-1092.88"/>
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+<!-- e_0_center&#45;&gt;accoa_c -->
+<g id="edge6" class="edge">
+<title>e_0_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1221.51,-1203.9C1200.78,-1189.13 1093.61,-1112.78 1045.87,-1078.76"/>
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+<!-- acald_e -->
+<g id="node8" class="node">
+<title>acald_e</title>
+<ellipse fill="none" stroke="black" cx="1918.06" cy="-1433.48" rx="18" ry="18"/>
+<text text-anchor="middle" x="1918.06" y="-1429.78" font-family="Times,serif" font-size="14.00">acald_e</text>
+</g>
+<!-- acald_e&#45;&gt;acald_c -->
+<g id="edge7" class="edge">
+<title>acald_e&#45;&gt;acald_c</title>
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+<!-- e_20_target -->
+<g id="node64" class="node">
+<title>e_20_target</title>
+<ellipse fill="black" stroke="black" cx="2159.66" cy="-1507.22" rx="1.8" ry="1.8"/>
+</g>
+<!-- acald_e&#45;&gt;e_20_target -->
+<g id="edge99" class="edge">
+<title>acald_e&#45;&gt;e_20_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1935.44,-1438.78C1982.1,-1453.02 2109.23,-1491.83 2148.17,-1503.71"/>
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+</g>
+<!-- ac_c -->
+<g id="node9" class="node">
+<title>ac_c</title>
+<ellipse fill="none" stroke="black" cx="464.62" cy="-1287.85" rx="18" ry="18"/>
+<text text-anchor="middle" x="464.62" y="-1284.15" font-family="Times,serif" font-size="14.00">ac_c</text>
+</g>
+<!-- e_2_center -->
+<g id="node13" class="node">
+<title>e_2_center</title>
+<polygon fill="none" stroke="black" points="567.08,-1052.48 560.08,-1052.48 560.08,-1045.48 567.08,-1045.48 567.08,-1052.48"/>
+</g>
+<!-- ac_c&#45;&gt;e_2_center -->
+<g id="edge8" class="edge">
+<title>ac_c&#45;&gt;e_2_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M471.58,-1271.05C492.17,-1221.35 551.98,-1076.96 562.11,-1052.52"/>
+</g>
+<!-- atp_c -->
+<g id="node10" class="node">
+<title>atp_c</title>
+<ellipse fill="none" stroke="black" cx="764.47" cy="-882.88" rx="18" ry="18"/>
+<text text-anchor="middle" x="764.47" y="-879.18" font-family="Times,serif" font-size="14.00">atp_c</text>
+</g>
+<!-- atp_c&#45;&gt;e_2_center -->
+<g id="edge9" class="edge">
+<title>atp_c&#45;&gt;e_2_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M749.57,-893.23C724.9,-910.55 674.3,-946.91 634.2,-981.08 607.02,-1004.25 576.91,-1035.1 566.96,-1045.43"/>
+</g>
+<!-- e_6_center -->
+<g id="node24" class="node">
+<title>e_6_center</title>
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+<!-- atp_c&#45;&gt;e_6_center -->
+<g id="edge23" class="edge">
+<title>atp_c&#45;&gt;e_6_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.78" d="M751.8,-869.72C722.87,-839.67 653.13,-767.22 636.15,-749.57"/>
+</g>
+<!-- e_10_center -->
+<g id="node34" class="node">
+<title>e_10_center</title>
+<polygon fill="none" stroke="black" points="760.63,-1061.88 753.63,-1061.88 753.63,-1054.88 760.63,-1054.88 760.63,-1061.88"/>
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+<!-- atp_c&#45;&gt;e_10_center -->
+<g id="edge41" class="edge">
+<title>atp_c&#45;&gt;e_10_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.75" d="M764.49,-901.01C764.18,-915.84 762.96,-937.28 758.96,-955.58 754.38,-976.54 743.28,-979.42 742.2,-1000.85 741.14,-1021.87 751.25,-1045.92 755.4,-1054.83"/>
+</g>
+<!-- atp_c&#45;&gt;e_12_center -->
+<g id="edge64" class="edge">
+<title>atp_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M782.03,-878.56C830.05,-866.74 961.51,-834.4 984.74,-828.68"/>
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+<!-- e_50_center -->
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+<title>e_50_center</title>
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+<!-- atp_c&#45;&gt;e_50_center -->
+<g id="edge160" class="edge">
+<title>atp_c&#45;&gt;e_50_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.4" d="M752.08,-895.98C738.97,-909.86 719.06,-930.91 710.98,-939.46"/>
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+<!-- e_51_center -->
+<g id="node116" class="node">
+<title>e_51_center</title>
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+</g>
+<!-- atp_c&#45;&gt;e_51_center -->
+<g id="edge169" class="edge">
+<title>atp_c&#45;&gt;e_51_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M750.51,-894.57C737.56,-905.43 717.79,-922.04 700.68,-936.57 679.43,-954.61 654.09,-976.42 644.67,-984.54"/>
+</g>
+<!-- e_71_center -->
+<g id="node136" class="node">
+<title>e_71_center</title>
+<polygon fill="none" stroke="black" points="903.81,-788.09 896.81,-788.09 896.81,-781.09 903.81,-781.09 903.81,-788.09"/>
+</g>
+<!-- atp_c&#45;&gt;e_71_center -->
+<g id="edge257" class="edge">
+<title>atp_c&#45;&gt;e_71_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.77" d="M779.27,-872.17C810.07,-849.88 879.64,-799.55 896.55,-787.31"/>
+</g>
+<!-- e_74_center -->
+<g id="node138" class="node">
+<title>e_74_center</title>
+<polygon fill="none" stroke="black" points="744.83,-694.55 737.83,-694.55 737.83,-687.55 744.83,-687.55 744.83,-694.55"/>
+</g>
+<!-- atp_c&#45;&gt;e_74_center -->
+<g id="edge267" class="edge">
+<title>atp_c&#45;&gt;e_74_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.27" d="M766.97,-864.94C768.18,-854.1 769.22,-840.02 768.44,-827.52 765.1,-774 747.16,-710.68 742.46,-694.8"/>
+</g>
+<!-- e_79_center -->
+<g id="node142" class="node">
+<title>e_79_center</title>
+<polygon fill="none" stroke="black" points="983.88,-797.06 976.88,-797.06 976.88,-790.06 983.88,-790.06 983.88,-797.06"/>
+</g>
+<!-- atp_c&#45;&gt;e_79_center -->
+<g id="edge286" class="edge">
+<title>atp_c&#45;&gt;e_79_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M781.41,-875.87C827.54,-856.79 953.47,-804.69 976.68,-795.09"/>
+</g>
+<!-- e_80_center -->
+<g id="node143" class="node">
+<title>e_80_center</title>
+<polygon fill="none" stroke="black" points="918.47,-862.84 911.47,-862.84 911.47,-855.84 918.47,-855.84 918.47,-862.84"/>
+</g>
+<!-- atp_c&#45;&gt;e_80_center -->
+<g id="edge293" class="edge">
+<title>atp_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.78" d="M782.33,-880.09C817.52,-874.58 893.95,-862.63 911.38,-859.9"/>
+</g>
+<!-- atp_c&#45;&gt;e_89_center -->
+<g id="edge326" class="edge">
+<title>atp_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M767.29,-901.02C776.23,-958.64 803.66,-1135.25 807.89,-1162.5"/>
+</g>
+<!-- adp_c -->
+<g id="node11" class="node">
+<title>adp_c</title>
+<ellipse fill="none" stroke="black" cx="802.41" cy="-929.72" rx="18" ry="18"/>
+<text text-anchor="middle" x="802.41" y="-926.02" font-family="Times,serif" font-size="14.00">adp_c</text>
+</g>
+<!-- e_11_center -->
+<g id="node35" class="node">
+<title>e_11_center</title>
+<polygon fill="none" stroke="black" points="852.21,-1118.11 845.21,-1118.11 845.21,-1111.11 852.21,-1111.11 852.21,-1118.11"/>
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+<!-- adp_c&#45;&gt;e_11_center -->
+<g id="edge46" class="edge">
+<title>adp_c&#45;&gt;e_11_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M805.35,-947.83C807.11,-958.02 809.51,-970.95 812.14,-982.36 824,-1033.9 842.79,-1095.5 847.58,-1110.96"/>
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+<!-- adp_c&#45;&gt;e_82_center -->
+<g id="edge302" class="edge">
+<title>adp_c&#45;&gt;e_82_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M819.86,-925.22C834.2,-921.59 855.06,-916.48 873.44,-912.64 912.97,-904.36 961.36,-896.58 974.86,-894.46"/>
+</g>
+<!-- actp_c -->
+<g id="node12" class="node">
+<title>actp_c</title>
+<ellipse fill="none" stroke="black" cx="476.98" cy="-1151.77" rx="18" ry="18"/>
+<text text-anchor="middle" x="476.98" y="-1148.07" font-family="Times,serif" font-size="14.00">actp_c</text>
+</g>
+<!-- e_2_center&#45;&gt;adp_c -->
+<g id="edge10" class="edge">
+<title>e_2_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M567.11,-1047.91C586.64,-1041.9 682.9,-1011.23 753.1,-969.39 762.87,-963.56 772.8,-955.97 781.16,-948.98"/>
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+</g>
+<!-- e_2_center&#45;&gt;actp_c -->
+<g id="edge11" class="edge">
+<title>e_2_center&#45;&gt;actp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M560.29,-1052.88C549.79,-1065.34 516.57,-1104.78 495.39,-1129.92"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="492.48,-1127.94 488.71,-1137.84 497.83,-1132.45 492.48,-1127.94"/>
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+<!-- cit_c -->
+<g id="node14" class="node">
+<title>cit_c</title>
+<ellipse fill="none" stroke="black" cx="499.3" cy="-1028.97" rx="18" ry="18"/>
+<text text-anchor="middle" x="499.3" y="-1025.27" font-family="Times,serif" font-size="14.00">cit_c</text>
+</g>
+<!-- e_3_center -->
+<g id="node17" class="node">
+<title>e_3_center</title>
+<polygon fill="none" stroke="black" points="417.08,-914.83 410.08,-914.83 410.08,-907.83 417.08,-907.83 417.08,-914.83"/>
+</g>
+<!-- cit_c&#45;&gt;e_3_center -->
+<g id="edge12" class="edge">
+<title>cit_c&#45;&gt;e_3_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M488.44,-1014.07C468.44,-986.62 426.83,-929.51 416.13,-914.83"/>
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+<!-- h2o_c -->
+<g id="node15" class="node">
+<title>h2o_c</title>
+<ellipse fill="none" stroke="black" cx="739.36" cy="-955.4" rx="18" ry="18"/>
+<text text-anchor="middle" x="739.36" y="-951.7" font-family="Times,serif" font-size="14.00">h2o_c</text>
+</g>
+<!-- e_4_center -->
+<g id="node19" class="node">
+<title>e_4_center</title>
+<polygon fill="none" stroke="black" points="439.95,-982.98 432.95,-982.98 432.95,-975.98 439.95,-975.98 439.95,-982.98"/>
+</g>
+<!-- h2o_c&#45;&gt;e_4_center -->
+<g id="edge15" class="edge">
+<title>h2o_c&#45;&gt;e_4_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M721.32,-956.84C661.21,-961.62 469.83,-976.83 440.3,-979.18"/>
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+<!-- h2o_c&#45;&gt;e_10_center -->
+<g id="edge40" class="edge">
+<title>h2o_c&#45;&gt;e_10_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.75" d="M739.71,-973.62C740.07,-981.96 740.79,-991.95 742.2,-1000.85 745.52,-1021.64 753.03,-1045.83 755.94,-1054.8"/>
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+<!-- h2o_c&#45;&gt;e_12_center -->
+<g id="edge58" class="edge">
+<title>h2o_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M752.79,-942.83C762.27,-934.41 775.56,-923.5 788.6,-915.81 842.97,-883.71 864.48,-892.8 921.67,-866.04 946.55,-854.4 974.52,-836.74 984.49,-830.29"/>
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+<!-- h2o_c&#45;&gt;e_14_center -->
+<g id="edge75" class="edge">
+<title>h2o_c&#45;&gt;e_14_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M754.27,-965.8C761.48,-971.42 769.83,-978.88 775.68,-987.03 796.79,-1016.42 804.21,-1061.32 806.02,-1074.63"/>
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+<!-- e_40_center -->
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+<!-- h2o_c&#45;&gt;e_40_center -->
+<g id="edge121" class="edge">
+<title>h2o_c&#45;&gt;e_40_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M750.42,-940.47C758.69,-928.91 769.96,-912.31 778.26,-896.81 815.47,-827.36 829.52,-729.64 832.06,-709.8"/>
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+<!-- e_45_center -->
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+<title>e_45_center</title>
+<polygon fill="none" stroke="black" points="836.29,-1310.83 829.29,-1310.83 829.29,-1303.83 836.29,-1303.83 836.29,-1310.83"/>
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+<!-- h2o_c&#45;&gt;e_45_center -->
+<g id="edge138" class="edge">
+<title>h2o_c&#45;&gt;e_45_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M739.14,-973.73C739.39,-982.1 740.18,-992.07 742.2,-1000.85 743.7,-1007.34 745.34,-1008.57 747.93,-1014.71 754.87,-1031.2 757.95,-1034.79 763.83,-1051.68 798.88,-1152.41 827.04,-1280.53 832.01,-1303.67"/>
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+<!-- h2o_c&#45;&gt;e_51_center -->
+<g id="edge167" class="edge">
+<title>h2o_c&#45;&gt;e_51_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M722.21,-961.04C698.41,-968.87 656.89,-982.53 644.49,-986.6"/>
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+<!-- e_52_center -->
+<g id="node117" class="node">
+<title>e_52_center</title>
+<polygon fill="none" stroke="black" points="883.64,-922.84 876.64,-922.84 876.64,-915.84 883.64,-915.84 883.64,-922.84"/>
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+<!-- h2o_c&#45;&gt;e_52_center -->
+<g id="edge174" class="edge">
+<title>h2o_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.82" d="M757.49,-954.95C770.19,-954.32 787.48,-952.83 802.34,-949.32 831.92,-942.32 865.32,-926.63 876.37,-921.22"/>
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+<!-- e_53_center -->
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+<!-- h2o_c&#45;&gt;e_53_center -->
+<g id="edge181" class="edge">
+<title>h2o_c&#45;&gt;e_53_center</title>
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+</g>
+<!-- h2o_c&#45;&gt;e_61_center -->
+<g id="edge214" class="edge">
+<title>h2o_c&#45;&gt;e_61_center</title>
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+<!-- e_75_center -->
+<g id="node139" class="node">
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+<!-- h2o_c&#45;&gt;e_75_center -->
+<g id="edge271" class="edge">
+<title>h2o_c&#45;&gt;e_75_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M757.33,-954.09C769.96,-953.06 787.22,-951.45 802.34,-949.32 889.72,-936.98 910.77,-929.03 997.54,-912.97 1032.11,-906.58 1073.99,-898.9 1086.23,-896.66"/>
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+<!-- e_78_center -->
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+<title>e_78_center</title>
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+<!-- h2o_c&#45;&gt;e_78_center -->
+<g id="edge280" class="edge">
+<title>h2o_c&#45;&gt;e_78_center</title>
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+<!-- h2o_c&#45;&gt;e_80_center -->
+<g id="edge291" class="edge">
+<title>h2o_c&#45;&gt;e_80_center</title>
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+<!-- acon_C_c -->
+<g id="node16" class="node">
+<title>acon_C_c</title>
+<ellipse fill="none" stroke="black" cx="210.14" cy="-912.3" rx="18" ry="18"/>
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+</g>
+<!-- acon_C_c&#45;&gt;e_4_center -->
+<g id="edge16" class="edge">
+<title>acon_C_c&#45;&gt;e_4_center</title>
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+</g>
+<!-- e_3_center&#45;&gt;h2o_c -->
+<g id="edge13" class="edge">
+<title>e_3_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M417.24,-911.82C446.1,-915.73 637.82,-941.67 711.03,-951.57"/>
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+<!-- e_3_center&#45;&gt;acon_C_c -->
+<g id="edge14" class="edge">
+<title>e_3_center&#45;&gt;acon_C_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M409.68,-910.92C393.15,-909.25 327.34,-903.08 273.22,-904.98 261.74,-905.39 249.14,-906.68 238.25,-908.06"/>
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+</g>
+<!-- icit_c -->
+<g id="node18" class="node">
+<title>icit_c</title>
+<ellipse fill="none" stroke="black" cx="634.63" cy="-1119.02" rx="18" ry="18"/>
+<text text-anchor="middle" x="634.63" y="-1115.32" font-family="Times,serif" font-size="14.00">icit_c</text>
+</g>
+<!-- e_58_center -->
+<g id="node124" class="node">
+<title>e_58_center</title>
+<polygon fill="none" stroke="black" points="987.48,-989.78 980.48,-989.78 980.48,-982.78 987.48,-982.78 987.48,-989.78"/>
+</g>
+<!-- icit_c&#45;&gt;e_58_center -->
+<g id="edge201" class="edge">
+<title>icit_c&#45;&gt;e_58_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M651.95,-1113.19C699.92,-1096.97 838.54,-1049.68 952.32,-1006.48 958.56,-1004.12 960.5,-1004.25 966.23,-1000.85 971.57,-997.67 976.99,-992.96 980.41,-989.76"/>
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+<!-- e_59_center -->
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+<title>e_59_center</title>
+<polygon fill="none" stroke="black" points="520.94,-1368.3 513.94,-1368.3 513.94,-1361.3 520.94,-1361.3 520.94,-1368.3"/>
+</g>
+<!-- icit_c&#45;&gt;e_59_center -->
+<g id="edge206" class="edge">
+<title>icit_c&#45;&gt;e_59_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M626.76,-1135.53C602.74,-1185.9 531.29,-1335.74 519.19,-1361.12"/>
+</g>
+<!-- e_4_center&#45;&gt;icit_c -->
+<g id="edge17" class="edge">
+<title>e_4_center&#45;&gt;icit_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M440.19,-980.74C451.69,-984.73 487.37,-997.81 513.24,-1015.19 535.2,-1029.95 536.91,-1038.32 556.88,-1055.68 575.17,-1071.58 596.56,-1088.92 612.27,-1101.43"/>
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+<!-- ac_e -->
+<g id="node20" class="node">
+<title>ac_e</title>
+<ellipse fill="none" stroke="black" cx="416.75" cy="-1683.11" rx="18" ry="18"/>
+<text text-anchor="middle" x="416.75" y="-1679.41" font-family="Times,serif" font-size="14.00">ac_e</text>
+</g>
+<!-- e_5_center -->
+<g id="node22" class="node">
+<title>e_5_center</title>
+<polygon fill="none" stroke="black" points="689.94,-1435.26 682.94,-1435.26 682.94,-1428.26 689.94,-1428.26 689.94,-1435.26"/>
+</g>
+<!-- ac_e&#45;&gt;e_5_center -->
+<g id="edge18" class="edge">
+<title>ac_e&#45;&gt;e_5_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M430.13,-1670.65C480.29,-1623.89 655.8,-1460.32 682.91,-1435.05"/>
+</g>
+<!-- e_19_target -->
+<g id="node63" class="node">
+<title>e_19_target</title>
+<ellipse fill="black" stroke="black" cx="227.74" cy="-1865.27" rx="1.8" ry="1.8"/>
+</g>
+<!-- ac_e&#45;&gt;e_19_target -->
+<g id="edge98" class="edge">
+<title>ac_e&#45;&gt;e_19_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M403.76,-1695.63C367.79,-1730.29 267.54,-1826.91 236.81,-1856.53"/>
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+<!-- h_e -->
+<g id="node21" class="node">
+<title>h_e</title>
+<ellipse fill="none" stroke="black" cx="991.51" cy="-1388.89" rx="18" ry="18"/>
+<text text-anchor="middle" x="991.51" y="-1385.19" font-family="Times,serif" font-size="14.00">h_e</text>
+</g>
+<!-- h_e&#45;&gt;e_5_center -->
+<g id="edge19" class="edge">
+<title>h_e&#45;&gt;e_5_center</title>
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+</g>
+<!-- e_8_center -->
+<g id="node30" class="node">
+<title>e_8_center</title>
+<polygon fill="none" stroke="black" points="1202.34,-1379.26 1195.34,-1379.26 1195.34,-1372.26 1202.34,-1372.26 1202.34,-1379.26"/>
+</g>
+<!-- h_e&#45;&gt;e_8_center -->
+<g id="edge31" class="edge">
+<title>h_e&#45;&gt;e_8_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1009.55,-1387.74C1055.06,-1384.86 1172.56,-1377.43 1195.08,-1376"/>
+</g>
+<!-- h_e&#45;&gt;e_11_center -->
+<g id="edge47" class="edge">
+<title>h_e&#45;&gt;e_11_center</title>
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+<!-- e_16_center -->
+<g id="node58" class="node">
+<title>e_16_center</title>
+<polygon fill="none" stroke="black" points="1224.69,-1500.08 1217.69,-1500.08 1217.69,-1493.08 1224.69,-1493.08 1224.69,-1500.08"/>
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+<!-- h_e&#45;&gt;e_16_center -->
+<g id="edge87" class="edge">
+<title>h_e&#45;&gt;e_16_center</title>
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+<!-- e_18_center -->
+<g id="node62" class="node">
+<title>e_18_center</title>
+<polygon fill="none" stroke="black" points="1172.85,-1550.08 1165.85,-1550.08 1165.85,-1543.08 1172.85,-1543.08 1172.85,-1550.08"/>
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+<!-- h_e&#45;&gt;e_18_center -->
+<g id="edge94" class="edge">
+<title>h_e&#45;&gt;e_18_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1005.17,-1401C1042.58,-1434.17 1145.29,-1525.25 1165.77,-1543.41"/>
+</g>
+<!-- e_30_target -->
+<g id="node80" class="node">
+<title>e_30_target</title>
+<ellipse fill="black" stroke="black" cx="1050.19" cy="-1667.04" rx="1.8" ry="1.8"/>
+</g>
+<!-- h_e&#45;&gt;e_30_target -->
+<g id="edge109" class="edge">
+<title>h_e&#45;&gt;e_30_target</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.04" d="M995.27,-1406.71C1006.3,-1458.98 1038.36,-1610.97 1047.64,-1654.97"/>
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+<!-- e_41_center -->
+<g id="node101" class="node">
+<title>e_41_center</title>
+<polygon fill="none" stroke="black" points="1277.74,-1407.87 1270.74,-1407.87 1270.74,-1400.87 1277.74,-1400.87 1277.74,-1407.87"/>
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+<!-- h_e&#45;&gt;e_41_center -->
+<g id="edge126" class="edge">
+<title>h_e&#45;&gt;e_41_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1009.63,-1389.88C1067.15,-1393.03 1243.5,-1402.68 1270.7,-1404.17"/>
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+<!-- e_46_center -->
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+<title>e_46_center</title>
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+<!-- h_e&#45;&gt;e_46_center -->
+<g id="edge141" class="edge">
+<title>h_e&#45;&gt;e_46_center</title>
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+<!-- e_55_center -->
+<g id="node120" class="node">
+<title>e_55_center</title>
+<polygon fill="none" stroke="black" points="701.09,-1292.59 694.09,-1292.59 694.09,-1285.59 701.09,-1285.59 701.09,-1292.59"/>
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+<!-- h_e&#45;&gt;e_55_center -->
+<g id="edge191" class="edge">
+<title>h_e&#45;&gt;e_55_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M974.49,-1382.82C934.48,-1368.59 831.27,-1332.14 744.37,-1303.65 728.52,-1298.45 709.52,-1292.68 701.48,-1290.26"/>
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+<!-- e_62_center -->
+<g id="node129" class="node">
+<title>e_62_center</title>
+<polygon fill="none" stroke="black" points="1096.7,-1520.84 1089.7,-1520.84 1089.7,-1513.84 1096.7,-1513.84 1096.7,-1520.84"/>
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+<!-- h_e&#45;&gt;e_62_center -->
+<g id="edge220" class="edge">
+<title>h_e&#45;&gt;e_62_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1002.78,-1403.12C1025.95,-1432.39 1077.8,-1497.88 1090.4,-1513.8"/>
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+<!-- e_77_center -->
+<g id="node140" class="node">
+<title>e_77_center</title>
+<polygon fill="none" stroke="black" points="741.17,-1313.85 734.17,-1313.85 734.17,-1306.85 741.17,-1306.85 741.17,-1313.85"/>
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+<!-- h_e&#45;&gt;e_77_center -->
+<g id="edge276" class="edge">
+<title>h_e&#45;&gt;e_77_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.25" d="M974.06,-1383.49C921.64,-1367.27 767.54,-1319.59 741.44,-1311.51"/>
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+<!-- e_83_center -->
+<g id="node146" class="node">
+<title>e_83_center</title>
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+<!-- h_e&#45;&gt;e_83_center -->
+<g id="edge307" class="edge">
+<title>h_e&#45;&gt;e_83_center</title>
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+</g>
+<!-- e_86_center -->
+<g id="node148" class="node">
+<title>e_86_center</title>
+<polygon fill="none" stroke="black" points="908.34,-1524.24 901.34,-1524.24 901.34,-1517.24 908.34,-1517.24 908.34,-1524.24"/>
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+<!-- h_e&#45;&gt;e_86_center -->
+<g id="edge314" class="edge">
+<title>h_e&#45;&gt;e_86_center</title>
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+<!-- e_87_center -->
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+<title>e_87_center</title>
+<polygon fill="none" stroke="black" points="880.82,-1511.72 873.82,-1511.72 873.82,-1504.72 880.82,-1504.72 880.82,-1511.72"/>
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+<!-- h_e&#45;&gt;e_87_center -->
+<g id="edge317" class="edge">
+<title>h_e&#45;&gt;e_87_center</title>
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+<!-- h_e&#45;&gt;e_91_center -->
+<g id="edge336" class="edge">
+<title>h_e&#45;&gt;e_91_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M999.68,-1372.66C1025.01,-1322.36 1101.28,-1170.93 1114.2,-1145.27"/>
+</g>
+<!-- e_5_center&#45;&gt;h_c -->
+<g id="edge21" class="edge">
+<title>e_5_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M690.22,-1429.65C700.12,-1424.07 727.53,-1408.24 748.65,-1392.59 832.48,-1330.5 922.1,-1244.38 961.07,-1205.82"/>
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+<!-- e_5_center&#45;&gt;ac_c -->
+<g id="edge20" class="edge">
+<title>e_5_center&#45;&gt;ac_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M682.59,-1429.26C659.64,-1414.37 540.06,-1336.79 488.42,-1303.29"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="490.18,-1300.26 479.89,-1297.75 486.37,-1306.13 490.18,-1300.26"/>
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+<!-- amp_c -->
+<g id="node23" class="node">
+<title>amp_c</title>
+<ellipse fill="none" stroke="black" cx="698.26" cy="-637.56" rx="18" ry="18"/>
+<text text-anchor="middle" x="698.26" y="-633.86" font-family="Times,serif" font-size="14.00">amp_c</text>
+</g>
+<!-- amp_c&#45;&gt;e_6_center -->
+<g id="edge22" class="edge">
+<title>amp_c&#45;&gt;e_6_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.78" d="M688.82,-653.04C673.31,-678.5 643.28,-727.76 634.71,-741.82"/>
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+<!-- e_6_center&#45;&gt;adp_c -->
+<g id="edge24" class="edge">
+<title>e_6_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.78" d="M634.57,-749.3C645.39,-767.12 694.83,-846.1 750.54,-896.67 758.52,-903.91 768.27,-910.58 777.16,-916"/>
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+<!-- akg_c -->
+<g id="node25" class="node">
+<title>akg_c</title>
+<ellipse fill="none" stroke="black" cx="1069.22" cy="-1067.79" rx="18" ry="18"/>
+<text text-anchor="middle" x="1069.22" y="-1064.09" font-family="Times,serif" font-size="14.00">akg_c</text>
+</g>
+<!-- akg_c&#45;&gt;e_7_center -->
+<g id="edge26" class="edge">
+<title>akg_c&#45;&gt;e_7_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1087.21,-1068.96C1097.32,-1069.82 1110.13,-1071.25 1121.38,-1073.52 1125.33,-1074.32 1182.71,-1091.67 1197.88,-1096.27"/>
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+<!-- akg_c&#45;&gt;e_54_center -->
+<g id="edge185" class="edge">
+<title>akg_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1054.01,-1058.15C1034.42,-1045.17 1000.17,-1020.51 977.28,-992.98 970.85,-985.25 973.21,-980.55 966.44,-973.13 960.53,-966.67 951.5,-961.55 946.43,-958.99"/>
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+<!-- co2_c -->
+<g id="node26" class="node">
+<title>co2_c</title>
+<ellipse fill="none" stroke="black" cx="1257.36" cy="-864.4" rx="18" ry="18"/>
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+<!-- co2_c&#45;&gt;e_78_center -->
+<g id="edge281" class="edge">
+<title>co2_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.84" d="M1239.49,-860.46C1230.09,-858.91 1218.38,-857.83 1207.97,-859.31 1169.3,-864.83 1166,-885.88 1128.52,-896.88 1081.79,-910.6 1022.65,-917.67 1007.76,-919.3"/>
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+<!-- succoa_c -->
+<g id="node27" class="node">
+<title>succoa_c</title>
+<ellipse fill="none" stroke="black" cx="1023.77" cy="-1259.8" rx="18" ry="18"/>
+<text text-anchor="middle" x="1023.77" y="-1256.1" font-family="Times,serif" font-size="14.00">succoa_c</text>
+</g>
+<!-- e_7_center&#45;&gt;nadh_c -->
+<g id="edge30" class="edge">
+<title>e_7_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1197.94,-1094.32C1195.21,-1092.01 1191.22,-1088.63 1186.96,-1085.01"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1189.11,-1082.24 1179.22,-1078.44 1184.58,-1087.58 1189.11,-1082.24"/>
+</g>
+<!-- e_7_center&#45;&gt;co2_c -->
+<g id="edge28" class="edge">
+<title>e_7_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1202.41,-1093.72C1207.87,-1070.93 1237.41,-947.64 1250.78,-891.85"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1254.23,-892.49 1253.15,-881.95 1247.42,-890.85 1254.23,-892.49"/>
+</g>
+<!-- e_7_center&#45;&gt;succoa_c -->
+<g id="edge29" class="edge">
+<title>e_7_center&#45;&gt;succoa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1197.82,-1100.77C1178.24,-1118.66 1086.31,-1202.65 1044.53,-1240.83"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1042.13,-1238.28 1037.11,-1247.61 1046.85,-1243.45 1042.13,-1238.28"/>
+</g>
+<!-- akg_e -->
+<g id="node29" class="node">
+<title>akg_e</title>
+<ellipse fill="none" stroke="black" cx="1460.4" cy="-1630.69" rx="18" ry="18"/>
+<text text-anchor="middle" x="1460.4" y="-1626.99" font-family="Times,serif" font-size="14.00">akg_e</text>
+</g>
+<!-- akg_e&#45;&gt;e_8_center -->
+<g id="edge32" class="edge">
+<title>akg_e&#45;&gt;e_8_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1446.27,-1618.85C1425.54,-1601.34 1385.86,-1567.28 1353.75,-1536.54 1290.47,-1475.96 1218.19,-1397.04 1202.11,-1379.38"/>
+</g>
+<!-- e_21_target -->
+<g id="node65" class="node">
+<title>e_21_target</title>
+<ellipse fill="black" stroke="black" cx="1658.89" cy="-1816.17" rx="1.8" ry="1.8"/>
+</g>
+<!-- akg_e&#45;&gt;e_21_target -->
+<g id="edge100" class="edge">
+<title>akg_e&#45;&gt;e_21_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1473.73,-1643.15C1511.38,-1678.33 1617.84,-1777.81 1649.75,-1807.62"/>
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+</g>
+<!-- e_8_center&#45;&gt;h_c -->
+<g id="edge34" class="edge">
+<title>e_8_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1195.06,-1372.47C1172.21,-1352.53 1051.91,-1247.56 1002.39,-1204.36"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1004.65,-1201.68 994.81,-1197.74 1000.04,-1206.95 1004.65,-1201.68"/>
+</g>
+<!-- e_8_center&#45;&gt;akg_c -->
+<g id="edge33" class="edge">
+<title>e_8_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1197.2,-1371.87C1185.08,-1343.07 1109,-1162.32 1080.23,-1093.95"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1083.44,-1092.56 1076.34,-1084.7 1076.99,-1095.28 1083.44,-1092.56"/>
+</g>
+<!-- etoh_c -->
+<g id="node31" class="node">
+<title>etoh_c</title>
+<ellipse fill="none" stroke="black" cx="1367.72" cy="-1522.79" rx="18" ry="18"/>
+<text text-anchor="middle" x="1367.72" y="-1519.09" font-family="Times,serif" font-size="14.00">etoh_c</text>
+</g>
+<!-- etoh_c&#45;&gt;e_9_center -->
+<g id="edge36" class="edge">
+<title>etoh_c&#45;&gt;e_9_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1361.81,-1505.78C1344.06,-1454.66 1291.9,-1304.4 1283.06,-1278.96"/>
+</g>
+<!-- e_9_center&#45;&gt;acald_c -->
+<g id="edge37" class="edge">
+<title>e_9_center&#45;&gt;acald_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1285.68,-1275.97C1312.04,-1280.66 1465.07,-1307.91 1529.21,-1319.32"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1528.95,-1322.83 1539.41,-1321.14 1530.17,-1315.94 1528.95,-1322.83"/>
+</g>
+<!-- e_9_center&#45;&gt;h_c -->
+<g id="edge39" class="edge">
+<title>e_9_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1277.98,-1274.14C1250.1,-1265.84 1076.43,-1214.14 1008.38,-1193.88"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1008.98,-1190.41 998.4,-1190.91 1006.98,-1197.12 1008.98,-1190.41"/>
+</g>
+<!-- e_9_center&#45;&gt;nadh_c -->
+<g id="edge38" class="edge">
+<title>e_9_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1279.76,-1271.65C1267.91,-1250.41 1206.95,-1141.19 1179.18,-1091.44"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1182.18,-1089.63 1174.25,-1082.61 1176.07,-1093.04 1182.18,-1089.63"/>
+</g>
+<!-- pi_c -->
+<g id="node33" class="node">
+<title>pi_c</title>
+<ellipse fill="none" stroke="black" cx="831.73" cy="-982.39" rx="18" ry="18"/>
+<text text-anchor="middle" x="831.73" y="-978.69" font-family="Times,serif" font-size="14.00">pi_c</text>
+</g>
+<!-- pi_c&#45;&gt;e_11_center -->
+<g id="edge45" class="edge">
+<title>pi_c&#45;&gt;e_11_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M834.06,-1000.49C838.09,-1031.9 846.15,-1094.65 848.22,-1110.77"/>
+</g>
+<!-- pi_c&#45;&gt;e_48_center -->
+<g id="edge150" class="edge">
+<title>pi_c&#45;&gt;e_48_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.27" d="M846.76,-971.79C887.48,-943.05 998.37,-864.8 1019.64,-849.79"/>
+</g>
+<!-- pi_c&#45;&gt;e_81_center -->
+<g id="edge298" class="edge">
+<title>pi_c&#45;&gt;e_81_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M823.63,-998.48C807.19,-1031.13 770.71,-1103.58 761.84,-1121.18"/>
+</g>
+<!-- e_10_center&#45;&gt;h_c -->
+<g id="edge44" class="edge">
+<title>e_10_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.75" d="M761,-1061.13C768.33,-1066.27 784.85,-1077.51 799.79,-1085.18 823.55,-1097.38 831.62,-1095.79 855.41,-1107.91 892.47,-1126.8 932.98,-1152.98 957.71,-1169.64"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.75" points="955.83,-1172.59 966.07,-1175.32 959.76,-1166.8 955.83,-1172.59"/>
+</g>
+<!-- e_10_center&#45;&gt;adp_c -->
+<g id="edge43" class="edge">
+<title>e_10_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.75" d="M758.68,-1054.77C761.87,-1047.3 769.4,-1029.62 775.65,-1014.75 778.23,-1008.6 779.18,-1007.18 781.4,-1000.9 786.46,-986.62 791.31,-970.44 795.06,-957.12"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.75" points="798.53,-957.71 797.83,-947.14 791.79,-955.84 798.53,-957.71"/>
+</g>
+<!-- e_10_center&#45;&gt;pi_c -->
+<g id="edge42" class="edge">
+<title>e_10_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.75" d="M760.73,-1054.72C769.8,-1045.48 794.11,-1020.71 811.77,-1002.73"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.75" points="814.35,-1005.09 818.86,-995.5 809.36,-1000.18 814.35,-1005.09"/>
+</g>
+<!-- e_11_center&#45;&gt;h_c -->
+<g id="edge50" class="edge">
+<title>e_11_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M852.25,-1116.51C866.77,-1124.32 922.54,-1154.29 955.75,-1172.15"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="953.99,-1176.16 964.87,-1177.04 958.13,-1168.46 953.99,-1176.16"/>
+</g>
+<!-- e_11_center&#45;&gt;atp_c -->
+<g id="edge49" class="edge">
+<title>e_11_center&#45;&gt;atp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M847.39,-1110.97C839.11,-1088.2 794.17,-964.57 774.13,-909.44"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="778.22,-907.89 770.69,-899.98 769.99,-910.88 778.22,-907.89"/>
+</g>
+<!-- e_11_center&#45;&gt;h2o_c -->
+<g id="edge48" class="edge">
+<title>e_11_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M847.09,-1110.78C840.15,-1094.61 811.62,-1030.83 775.68,-987.03 771.6,-982.06 766.7,-977.22 761.84,-972.89"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="764.3,-969.24 753.83,-966.13 758.65,-975.93 764.3,-969.24"/>
+</g>
+<!-- gln__L_c -->
+<g id="node36" class="node">
+<title>gln__L_c</title>
+<ellipse fill="none" stroke="black" cx="748.84" cy="-827.41" rx="18" ry="18"/>
+<text text-anchor="middle" x="748.84" y="-823.71" font-family="Times,serif" font-size="14.00">gln__L_c</text>
+</g>
+<!-- gln__L_c&#45;&gt;e_12_center -->
+<g id="edge51" class="edge">
+<title>gln__L_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M767.23,-827.44C818.26,-827.53 959.51,-827.77 984.48,-827.81"/>
+</g>
+<!-- gln__L_c&#45;&gt;e_53_center -->
+<g id="edge182" class="edge">
+<title>gln__L_c&#45;&gt;e_53_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M730.9,-829.49C693.69,-833.78 610.01,-843.45 590.91,-845.66"/>
+</g>
+<!-- gln__L_c&#45;&gt;e_54_center -->
+<g id="edge187" class="edge">
+<title>gln__L_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M764.54,-836.28C790.57,-851.16 844.01,-882.49 886.84,-912.64 907.31,-927.05 930.22,-946.45 938.97,-954"/>
+</g>
+<!-- 3pg_c -->
+<g id="node37" class="node">
+<title>3pg_c</title>
+<ellipse fill="none" stroke="black" cx="815.53" cy="-556.84" rx="18" ry="18"/>
+<text text-anchor="middle" x="815.53" y="-553.14" font-family="Times,serif" font-size="14.00">3pg_c</text>
+</g>
+<!-- 3pg_c&#45;&gt;e_12_center -->
+<g id="edge52" class="edge">
+<title>3pg_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M825.31,-572.18C858.86,-624.81 968.14,-796.23 985.84,-824"/>
+</g>
+<!-- 3pg_c&#45;&gt;e_74_center -->
+<g id="edge268" class="edge">
+<title>3pg_c&#45;&gt;e_74_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.27" d="M806.73,-572.76C789.53,-603.87 752.36,-671.11 743.33,-687.43"/>
+</g>
+<!-- f6p_c -->
+<g id="node38" class="node">
+<title>f6p_c</title>
+<ellipse fill="none" stroke="black" cx="1038.14" cy="-546.2" rx="18" ry="18"/>
+<text text-anchor="middle" x="1038.14" y="-542.5" font-family="Times,serif" font-size="14.00">f6p_c</text>
+</g>
+<!-- f6p_c&#45;&gt;e_12_center -->
+<g id="edge53" class="edge">
+<title>f6p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M1034.94,-564.24C1024.8,-621.54 993.7,-797.19 988.9,-824.29"/>
+</g>
+<!-- f6p_c&#45;&gt;e_71_center -->
+<g id="edge258" class="edge">
+<title>f6p_c&#45;&gt;e_71_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.77" d="M1029.09,-561.84C1001.06,-610.32 916.67,-756.28 902.38,-781.01"/>
+</g>
+<!-- pyr_c -->
+<g id="node39" class="node">
+<title>pyr_c</title>
+<ellipse fill="none" stroke="black" cx="1207.84" cy="-878.91" rx="18" ry="18"/>
+<text text-anchor="middle" x="1207.84" y="-875.21" font-family="Times,serif" font-size="14.00">pyr_c</text>
+</g>
+<!-- pyr_c&#45;&gt;e_12_center -->
+<g id="edge54" class="edge">
+<title>pyr_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M1190.29,-873.93C1174.28,-869.45 1149.95,-862.8 1128.63,-857.68 1074.85,-844.76 1008.8,-831.79 992.2,-828.57"/>
+</g>
+<!-- pyr_c&#45;&gt;e_70_center -->
+<g id="edge252" class="edge">
+<title>pyr_c&#45;&gt;e_70_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.7" d="M1210.23,-897.07C1210.72,-901.54 1211.17,-906.31 1211.41,-910.76 1213.22,-942.96 1202.52,-981.25 1198.96,-992.95"/>
+</g>
+<!-- pyr_c&#45;&gt;e_72_center -->
+<g id="edge263" class="edge">
+<title>pyr_c&#45;&gt;e_72_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1213.13,-896.28C1228.55,-946.89 1272.84,-1092.24 1280.34,-1116.84"/>
+</g>
+<!-- pyr_c&#45;&gt;e_80_center -->
+<g id="edge292" class="edge">
+<title>pyr_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.78" d="M1190.8,-872.91C1174.94,-867.67 1150.52,-860.48 1128.63,-857.68 1085.58,-852.18 942.71,-858.12 918.48,-859.18"/>
+</g>
+<!-- r5p_c -->
+<g id="node40" class="node">
+<title>r5p_c</title>
+<ellipse fill="none" stroke="black" cx="1123.47" cy="-472.63" rx="18" ry="18"/>
+<text text-anchor="middle" x="1123.47" y="-468.93" font-family="Times,serif" font-size="14.00">r5p_c</text>
+</g>
+<!-- r5p_c&#45;&gt;e_12_center -->
+<g id="edge56" class="edge">
+<title>r5p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M1116.95,-489.76C1091.85,-555.72 1002.2,-791.22 989.72,-824.01"/>
+</g>
+<!-- ru5p__D_c -->
+<g id="node122" class="node">
+<title>ru5p__D_c</title>
+<ellipse fill="none" stroke="black" cx="1303.98" cy="-377.26" rx="18" ry="18"/>
+<text text-anchor="middle" x="1303.98" y="-373.56" font-family="Times,serif" font-size="14.00">ru5p__D_c</text>
+</g>
+<!-- r5p_c&#45;&gt;ru5p__D_c -->
+<g id="edge312" class="edge">
+<title>r5p_c&#45;&gt;ru5p__D_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.05" d="M1139.49,-464.16C1170.94,-447.55 1240.95,-410.56 1278.7,-390.62"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.05" points="1280.79,-393.47 1288,-385.71 1277.52,-387.29 1280.79,-393.47"/>
+</g>
+<!-- e_92_center -->
+<g id="node155" class="node">
+<title>e_92_center</title>
+<polygon fill="none" stroke="black" points="1120.35,-228.53 1113.35,-228.53 1113.35,-221.53 1120.35,-221.53 1120.35,-228.53"/>
+</g>
+<!-- r5p_c&#45;&gt;e_92_center -->
+<g id="edge342" class="edge">
+<title>r5p_c&#45;&gt;e_92_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.91" d="M1123.76,-454.27C1124.14,-423.75 1124.57,-360.65 1122.57,-307.31 1121.43,-276.97 1118.26,-240.45 1117.2,-228.79"/>
+</g>
+<!-- e4p_c -->
+<g id="node41" class="node">
+<title>e4p_c</title>
+<ellipse fill="none" stroke="black" cx="1053.21" cy="-471.31" rx="18" ry="18"/>
+<text text-anchor="middle" x="1053.21" y="-467.61" font-family="Times,serif" font-size="14.00">e4p_c</text>
+</g>
+<!-- e4p_c&#45;&gt;e_12_center -->
+<g id="edge57" class="edge">
+<title>e4p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M1055.8,-489.2C1057.65,-504.4 1059.51,-526.78 1057.74,-546.26 1047.11,-663.08 998.29,-800.49 989.6,-824.23"/>
+</g>
+<!-- e_93_center -->
+<g id="node156" class="node">
+<title>e_93_center</title>
+<polygon fill="none" stroke="black" points="1119.37,-317.51 1112.37,-317.51 1112.37,-310.51 1119.37,-310.51 1119.37,-317.51"/>
+</g>
+<!-- e4p_c&#45;&gt;e_93_center -->
+<g id="edge345" class="edge">
+<title>e4p_c&#45;&gt;e_93_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.85" d="M1059.91,-454.47C1074.18,-418.65 1106.87,-336.6 1114.33,-317.87"/>
+</g>
+<!-- g3p_c -->
+<g id="node42" class="node">
+<title>g3p_c</title>
+<ellipse fill="none" stroke="black" cx="1005.27" cy="-459.71" rx="18" ry="18"/>
+<text text-anchor="middle" x="1005.27" y="-456.01" font-family="Times,serif" font-size="14.00">g3p_c</text>
+</g>
+<!-- g3p_c&#45;&gt;e_12_center -->
+<g id="edge59" class="edge">
+<title>g3p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M1004.44,-477.71C1001.25,-546.71 989.93,-792.02 988.44,-824.3"/>
+</g>
+<!-- g3p_c&#45;&gt;e_48_center -->
+<g id="edge152" class="edge">
+<title>g3p_c&#45;&gt;e_48_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.27" d="M1006.11,-477.88C1009.42,-549.42 1021.44,-809.35 1023.02,-843.56"/>
+</g>
+<!-- e_90_center -->
+<g id="node153" class="node">
+<title>e_90_center</title>
+<polygon fill="none" stroke="black" points="1050.03,-283.06 1043.03,-283.06 1043.03,-276.06 1050.03,-276.06 1050.03,-283.06"/>
+</g>
+<!-- g3p_c&#45;&gt;e_90_center -->
+<g id="edge332" class="edge">
+<title>g3p_c&#45;&gt;e_90_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.91" d="M1009.3,-442.11C1018.59,-401.56 1041.05,-303.48 1045.68,-283.25"/>
+</g>
+<!-- g6p_c -->
+<g id="node43" class="node">
+<title>g6p_c</title>
+<ellipse fill="none" stroke="black" cx="1195.72" cy="-670.74" rx="18" ry="18"/>
+<text text-anchor="middle" x="1195.72" y="-667.04" font-family="Times,serif" font-size="14.00">g6p_c</text>
+</g>
+<!-- g6p_c&#45;&gt;f6p_c -->
+<g id="edge266" class="edge">
+<title>g6p_c&#45;&gt;f6p_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.4" d="M1181.45,-659.47C1154.05,-637.81 1093.85,-590.23 1060.86,-564.15"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.4" points="1062.72,-561.17 1052.71,-557.71 1058.38,-566.66 1062.72,-561.17"/>
+</g>
+<!-- g6p_c&#45;&gt;e_12_center -->
+<g id="edge60" class="edge">
+<title>g6p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M1181.13,-681.78C1138.34,-714.19 1014.72,-807.79 991.92,-825.06"/>
+</g>
+<!-- e_47_center -->
+<g id="node110" class="node">
+<title>e_47_center</title>
+<polygon fill="none" stroke="black" points="1208.21,-920.96 1201.21,-920.96 1201.21,-913.96 1208.21,-913.96 1208.21,-920.96"/>
+</g>
+<!-- g6p_c&#45;&gt;e_47_center -->
+<g id="edge146" class="edge">
+<title>g6p_c&#45;&gt;e_47_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1192.55,-688.72C1186.73,-725 1175.97,-809.38 1188.24,-878.78 1190.63,-892.29 1198.39,-906.82 1202.35,-913.58"/>
+</g>
+<!-- pep_c -->
+<g id="node44" class="node">
+<title>pep_c</title>
+<ellipse fill="none" stroke="black" cx="1071.25" cy="-682.94" rx="18" ry="18"/>
+<text text-anchor="middle" x="1071.25" y="-679.24" font-family="Times,serif" font-size="14.00">pep_c</text>
+</g>
+<!-- pep_c&#45;&gt;e_12_center -->
+<g id="edge62" class="edge">
+<title>pep_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M1062.21,-698.72C1043.22,-731.87 1000.14,-807.1 990.3,-824.28"/>
+</g>
+<!-- e_44_center -->
+<g id="node105" class="node">
+<title>e_44_center</title>
+<polygon fill="none" stroke="black" points="1274.78,-525.21 1267.78,-525.21 1267.78,-518.21 1274.78,-518.21 1274.78,-525.21"/>
+</g>
+<!-- pep_c&#45;&gt;e_44_center -->
+<g id="edge135" class="edge">
+<title>pep_c&#45;&gt;e_44_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1085.31,-671.6C1126.57,-638.34 1245.78,-542.26 1267.77,-524.53"/>
+</g>
+<!-- e_49_center -->
+<g id="node113" class="node">
+<title>e_49_center</title>
+<polygon fill="none" stroke="black" points="1359.54,-592.38 1352.54,-592.38 1352.54,-585.38 1359.54,-585.38 1359.54,-592.38"/>
+</g>
+<!-- pep_c&#45;&gt;e_49_center -->
+<g id="edge157" class="edge">
+<title>pep_c&#45;&gt;e_49_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.3" d="M1088.63,-677.19C1145.63,-658.37 1324.79,-599.2 1352.44,-590.07"/>
+</g>
+<!-- pep_c&#45;&gt;e_78_center -->
+<g id="edge282" class="edge">
+<title>pep_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.84" d="M1067.79,-700.63C1061.5,-731.92 1047.22,-798.9 1029.89,-853.99 1022.25,-878.28 1010.09,-906.46 1005.8,-916.17"/>
+</g>
+<!-- pep_c&#45;&gt;e_82_center -->
+<g id="edge303" class="edge">
+<title>pep_c&#45;&gt;e_82_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1063.97,-699.49C1044.15,-744.56 990.06,-867.6 980.09,-890.27"/>
+</g>
+<!-- oaa_c -->
+<g id="node45" class="node">
+<title>oaa_c</title>
+<ellipse fill="none" stroke="black" cx="952.47" cy="-986.88" rx="18" ry="18"/>
+<text text-anchor="middle" x="952.47" y="-983.18" font-family="Times,serif" font-size="14.00">oaa_c</text>
+</g>
+<!-- oaa_c&#45;&gt;e_12_center -->
+<g id="edge63" class="edge">
+<title>oaa_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M955.54,-968.78C959.04,-948.73 965.14,-915.5 971.8,-887.19 976.8,-865.94 984.29,-840.86 987.13,-831.54"/>
+</g>
+<!-- oaa_c&#45;&gt;e_14_center -->
+<g id="edge77" class="edge">
+<title>oaa_c&#45;&gt;e_14_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M937.13,-996.51C904.04,-1017.27 827.56,-1065.26 810.09,-1076.22"/>
+</g>
+<!-- oaa_c&#45;&gt;e_79_center -->
+<g id="edge287" class="edge">
+<title>oaa_c&#45;&gt;e_79_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M955.05,-969.04C961.25,-926.04 976.76,-818.66 979.84,-797.29"/>
+</g>
+<!-- nadph_c -->
+<g id="node46" class="node">
+<title>nadph_c</title>
+<ellipse fill="none" stroke="black" cx="1130.02" cy="-921.3" rx="18" ry="18"/>
+<text text-anchor="middle" x="1130.02" y="-917.6" font-family="Times,serif" font-size="14.00">nadph_c</text>
+</g>
+<!-- nadph_c&#45;&gt;e_12_center -->
+<g id="edge65" class="edge">
+<title>nadph_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M1112.58,-915.6C1103.52,-912.34 1092.42,-907.88 1083.05,-902.71 1043.76,-881.02 1003.93,-843.26 991.92,-831.45"/>
+</g>
+<!-- nadph_c&#45;&gt;e_54_center -->
+<g id="edge188" class="edge">
+<title>nadph_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1112.05,-924.74C1069.92,-932.81 966.75,-952.57 946.23,-956.5"/>
+</g>
+<!-- nadph_c&#45;&gt;e_67_center -->
+<g id="edge246" class="edge">
+<title>nadph_c&#45;&gt;e_67_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1147.67,-924.84C1186.07,-932.54 1275.28,-950.44 1294.34,-954.26"/>
+</g>
+<!-- glu__L_c -->
+<g id="node47" class="node">
+<title>glu__L_c</title>
+<ellipse fill="none" stroke="black" cx="761.8" cy="-1000.87" rx="18" ry="18"/>
+<text text-anchor="middle" x="761.8" y="-997.17" font-family="Times,serif" font-size="14.00">glu__L_c</text>
+</g>
+<!-- glu__L_c&#45;&gt;e_12_center -->
+<g id="edge66" class="edge">
+<title>glu__L_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M776.14,-989.3C797.27,-972.29 838.1,-939.64 873.44,-912.64 916.76,-879.53 970.43,-840.68 984.67,-830.41"/>
+</g>
+<!-- glu__L_c&#45;&gt;e_50_center -->
+<g id="edge162" class="edge">
+<title>glu__L_c&#45;&gt;e_50_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.4" d="M747.22,-989.57C740.24,-983.83 731.99,-976.51 725.38,-969.14 718.81,-961.81 712.58,-951.99 709.46,-946.81"/>
+</g>
+<!-- glu__L_c&#45;&gt;e_52_center -->
+<g id="edge176" class="edge">
+<title>glu__L_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.82" d="M776.79,-990.55C804.4,-971.52 861.84,-931.94 876.61,-921.77"/>
+</g>
+<!-- nadp_c -->
+<g id="node48" class="node">
+<title>nadp_c</title>
+<ellipse fill="none" stroke="black" cx="1128.57" cy="-877.28" rx="18" ry="18"/>
+<text text-anchor="middle" x="1128.57" y="-873.58" font-family="Times,serif" font-size="14.00">nadp_c</text>
+</g>
+<!-- nadp_c&#45;&gt;e_47_center -->
+<g id="edge145" class="edge">
+<title>nadp_c&#45;&gt;e_47_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1144.72,-885.8C1162.88,-895.38 1191.14,-910.29 1201.09,-915.54"/>
+</g>
+<!-- nadp_c&#45;&gt;e_52_center -->
+<g id="edge175" class="edge">
+<title>nadp_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.82" d="M1110.71,-880.31C1058.64,-889.12 909.11,-914.43 883.8,-918.72"/>
+</g>
+<!-- e_56_center -->
+<g id="node123" class="node">
+<title>e_56_center</title>
+<polygon fill="none" stroke="black" points="1270.63,-674.19 1263.63,-674.19 1263.63,-667.19 1270.63,-667.19 1270.63,-674.19"/>
+</g>
+<!-- nadp_c&#45;&gt;e_56_center -->
+<g id="edge196" class="edge">
+<title>nadp_c&#45;&gt;e_56_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1138.76,-862.09C1167.76,-818.85 1249.63,-696.79 1264.72,-674.28"/>
+</g>
+<!-- nadp_c&#45;&gt;e_58_center -->
+<g id="edge202" class="edge">
+<title>nadp_c&#45;&gt;e_58_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M1114.26,-888.77C1108.72,-893.17 1102.32,-898.21 1096.45,-902.71 1053.99,-935.28 1001.44,-973.59 987.5,-983.72"/>
+</g>
+<!-- e_65_center -->
+<g id="node132" class="node">
+<title>e_65_center</title>
+<polygon fill="none" stroke="black" points="1260.89,-1014.85 1253.89,-1014.85 1253.89,-1007.85 1260.89,-1007.85 1260.89,-1014.85"/>
+</g>
+<!-- nadp_c&#45;&gt;e_65_center -->
+<g id="edge234" class="edge">
+<title>nadp_c&#45;&gt;e_65_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1141.4,-890.63C1169.91,-920.3 1237.33,-990.48 1253.74,-1007.56"/>
+</g>
+<!-- nadp_c&#45;&gt;e_91_center -->
+<g id="edge335" class="edge">
+<title>nadp_c&#45;&gt;e_91_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1120.3,-893.49C1116.58,-901.58 1112.56,-911.63 1110.42,-921.11 1093.59,-995.72 1092.58,-1017.04 1101.65,-1092.99 1103.69,-1110.11 1111.06,-1129.48 1114.4,-1137.63"/>
+</g>
+<!-- e_12_center&#45;&gt;coa_c -->
+<g id="edge67" class="edge">
+<title>e_12_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M988.24,-831.43C988.1,-853.22 988.11,-969.33 1003.27,-1062.35 1004.16,-1067.79 1005.43,-1073.53 1006.81,-1079.01"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.39" points="1003.54,-1080.32 1009.52,-1089.06 1010.3,-1078.5 1003.54,-1080.32"/>
+</g>
+<!-- e_12_center&#45;&gt;h_c -->
+<g id="edge73" class="edge">
+<title>e_12_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M988.36,-831.57C988.72,-848.63 990.21,-920.56 990.68,-979.58 991.18,-1043.26 986.35,-1117.88 983.36,-1157.56"/>
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+</g>
+<!-- e_12_center&#45;&gt;nadh_c -->
+<g id="edge69" class="edge">
+<title>e_12_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M991.06,-831.57C1008.94,-855.69 1108.25,-989.65 1148.46,-1043.89"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.39" points="1145.84,-1046.23 1154.61,-1052.18 1151.46,-1042.06 1145.84,-1046.23"/>
+</g>
+<!-- e_12_center&#45;&gt;adp_c -->
+<g id="edge71" class="edge">
+<title>e_12_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M984.69,-829.93C974.74,-835.77 945.93,-852.61 921.67,-866.04 889.4,-883.91 851.81,-903.83 827.59,-916.56"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.39" points="825.93,-913.48 818.7,-921.22 829.18,-919.68 825.93,-913.48"/>
+</g>
+<!-- e_12_center&#45;&gt;akg_c -->
+<g id="edge68" class="edge">
+<title>e_12_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M989.55,-831.58C997.52,-855.22 1040.89,-983.8 1060.08,-1040.69"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.39" points="1056.85,-1042.08 1063.36,-1050.43 1063.48,-1039.84 1056.85,-1042.08"/>
+</g>
+<!-- e_12_center&#45;&gt;pi_c -->
+<g id="edge70" class="edge">
+<title>e_12_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M984.71,-831.33C967.21,-848.62 889.67,-925.18 852.17,-962.21"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.39" points="849.47,-959.95 844.82,-969.47 854.39,-964.93 849.47,-959.95"/>
+</g>
+<!-- e_12_center&#45;&gt;nadp_c -->
+<g id="edge72" class="edge">
+<title>e_12_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.39" d="M992.2,-828.94C999.61,-831.07 1016.15,-835.93 1029.89,-840.59 1054.51,-848.93 1082.23,-859.33 1102.01,-866.92"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.39" points="1100.98,-870.28 1111.57,-870.61 1103.5,-863.75 1100.98,-870.28"/>
+</g>
+<!-- co2_e -->
+<g id="node50" class="node">
+<title>co2_e</title>
+<ellipse fill="none" stroke="black" cx="1628.62" cy="-713.55" rx="18" ry="18"/>
+<text text-anchor="middle" x="1628.62" y="-709.85" font-family="Times,serif" font-size="14.00">co2_e</text>
+</g>
+<!-- co2_e&#45;&gt;co2_c -->
+<g id="edge74" class="edge">
+<title>co2_e&#45;&gt;co2_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.4" d="M1611.7,-720.42C1552.75,-744.38 1356.06,-824.29 1284.06,-853.55"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.4" points="1282.32,-850.48 1274.37,-857.48 1284.96,-856.96 1282.32,-850.48"/>
+</g>
+<!-- e_22_target -->
+<g id="node66" class="node">
+<title>e_22_target</title>
+<ellipse fill="black" stroke="black" cx="1877.52" cy="-612.17" rx="1.8" ry="1.8"/>
+</g>
+<!-- co2_e&#45;&gt;e_22_target -->
+<g id="edge101" class="edge">
+<title>co2_e&#45;&gt;e_22_target</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.9" d="M1645.34,-706.74C1692.55,-687.51 1826.04,-633.14 1866.05,-616.84"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.9" points="1867.89,-620.73 1875.53,-612.98 1864.65,-612.78 1867.89,-620.73"/>
+</g>
+<!-- e_14_center&#45;&gt;coa_c -->
+<g id="edge79" class="edge">
+<title>e_14_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M810.11,-1078.96C830.91,-1081.76 936.09,-1095.91 987.13,-1102.77"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.26" points="986.77,-1106.25 997.15,-1104.12 987.71,-1099.31 986.77,-1106.25"/>
+</g>
+<!-- e_14_center&#45;&gt;h_c -->
+<g id="edge80" class="edge">
+<title>e_14_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M810.06,-1080.6C818.15,-1085.43 838.49,-1097.58 855.41,-1107.91 890.92,-1129.59 931.84,-1155.02 957.08,-1170.76"/>
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+</g>
+<!-- e_14_center&#45;&gt;cit_c -->
+<g id="edge78" class="edge">
+<title>e_14_center&#45;&gt;cit_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M802.61,-1077.85C774.19,-1073.27 597.53,-1044.8 527.68,-1033.54"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.26" points="527.85,-1030.03 517.42,-1031.89 526.74,-1036.94 527.85,-1030.03"/>
+</g>
+<!-- q8h2_c -->
+<g id="node52" class="node">
+<title>q8h2_c</title>
+<ellipse fill="none" stroke="black" cx="812.2" cy="-1566.75" rx="18" ry="18"/>
+<text text-anchor="middle" x="812.2" y="-1563.05" font-family="Times,serif" font-size="14.00">q8h2_c</text>
+</g>
+<!-- q8h2_c&#45;&gt;e_15_center -->
+<g id="edge81" class="edge">
+<title>q8h2_c&#45;&gt;e_15_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M805.59,-1549.74C789.95,-1509.46 751.37,-1410.13 743.41,-1389.63"/>
+</g>
+<!-- e_43_center -->
+<g id="node104" class="node">
+<title>e_43_center</title>
+<polygon fill="none" stroke="black" points="707.93,-1708.25 700.93,-1708.25 700.93,-1701.25 707.93,-1701.25 707.93,-1708.25"/>
+</g>
+<!-- q8h2_c&#45;&gt;e_43_center -->
+<g id="edge130" class="edge">
+<title>q8h2_c&#45;&gt;e_43_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M796.86,-1576.17C787.24,-1582.58 775.01,-1591.69 766.01,-1601.73 735.42,-1635.87 711.93,-1687.41 705.93,-1701.23"/>
+</g>
+<!-- o2_c -->
+<g id="node53" class="node">
+<title>o2_c</title>
+<ellipse fill="none" stroke="black" cx="496.9" cy="-1726.81" rx="18" ry="18"/>
+<text text-anchor="middle" x="496.9" y="-1723.11" font-family="Times,serif" font-size="14.00">o2_c</text>
+</g>
+<!-- o2_c&#45;&gt;e_15_center -->
+<g id="edge83" class="edge">
+<title>o2_c&#45;&gt;e_15_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M507.43,-1712.16C551.04,-1651.49 716.27,-1421.63 739.29,-1389.6"/>
+</g>
+<!-- q8_c -->
+<g id="node54" class="node">
+<title>q8_c</title>
+<ellipse fill="none" stroke="black" cx="763.56" cy="-1560.62" rx="18" ry="18"/>
+<text text-anchor="middle" x="763.56" y="-1556.92" font-family="Times,serif" font-size="14.00">q8_c</text>
+</g>
+<!-- q8_c&#45;&gt;e_66_center -->
+<g id="edge239" class="edge">
+<title>q8_c&#45;&gt;e_66_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M776.05,-1547.62C817.15,-1504.84 946.85,-1369.83 969.82,-1345.92"/>
+</g>
+<!-- e_88_center -->
+<g id="node150" class="node">
+<title>e_88_center</title>
+<polygon fill="none" stroke="black" points="668.49,-1684.22 661.49,-1684.22 661.49,-1677.22 668.49,-1677.22 668.49,-1684.22"/>
+</g>
+<!-- q8_c&#45;&gt;e_88_center -->
+<g id="edge321" class="edge">
+<title>q8_c&#45;&gt;e_88_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M751.86,-1574.87C729.22,-1602.46 680.52,-1661.8 667.98,-1677.08"/>
+</g>
+<!-- e_15_center&#45;&gt;h2o_c -->
+<g id="edge84" class="edge">
+<title>e_15_center&#45;&gt;h2o_c</title>
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+<!-- e_15_center&#45;&gt;h_e -->
+<g id="edge86" class="edge">
+<title>e_15_center&#45;&gt;h_e</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M745.48,-1385.93C768.96,-1386.21 903.51,-1387.83 963.11,-1388.54"/>
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+<!-- e_15_center&#45;&gt;q8_c -->
+<g id="edge85" class="edge">
+<title>e_15_center&#45;&gt;q8_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M742.41,-1389.54C744.65,-1407.69 754.72,-1489.14 760.11,-1532.79"/>
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+<!-- lac__D_e -->
+<g id="node56" class="node">
+<title>lac__D_e</title>
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+<text text-anchor="middle" x="1432.18" y="-1781.34" font-family="Times,serif" font-size="14.00">lac__D_e</text>
+</g>
+<!-- lac__D_e&#45;&gt;e_16_center -->
+<g id="edge88" class="edge">
+<title>lac__D_e&#45;&gt;e_16_center</title>
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+<!-- e_32_target -->
+<g id="node83" class="node">
+<title>e_32_target</title>
+<ellipse fill="black" stroke="black" cx="1591.94" cy="-2000.26" rx="1.8" ry="1.8"/>
+</g>
+<!-- lac__D_e&#45;&gt;e_32_target -->
+<g id="edge111" class="edge">
+<title>lac__D_e&#45;&gt;e_32_target</title>
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+<!-- lac__D_c -->
+<g id="node57" class="node">
+<title>lac__D_c</title>
+<ellipse fill="none" stroke="black" cx="1392.51" cy="-1386.26" rx="18" ry="18"/>
+<text text-anchor="middle" x="1392.51" y="-1382.56" font-family="Times,serif" font-size="14.00">lac__D_c</text>
+</g>
+<!-- lac__D_c&#45;&gt;e_60_center -->
+<g id="edge209" class="edge">
+<title>lac__D_c&#45;&gt;e_60_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1382.32,-1370.76C1362.29,-1340.12 1316.64,-1269.44 1281.18,-1208.27 1271.49,-1191.56 1260.9,-1171.03 1256.74,-1162.85"/>
+</g>
+<!-- e_16_center&#45;&gt;h_c -->
+<g id="edge90" class="edge">
+<title>e_16_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1218.76,-1492.92C1203.38,-1469.83 1117.61,-1342.21 1037.66,-1245.97 1026.19,-1232.16 1012.41,-1217.47 1001.32,-1206.05"/>
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+<!-- e_16_center&#45;&gt;lac__D_c -->
+<g id="edge89" class="edge">
+<title>e_16_center&#45;&gt;lac__D_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1224.76,-1494.27C1243.07,-1482.48 1327.04,-1428.42 1368.79,-1401.53"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1370.75,-1404.43 1377.26,-1396.08 1366.96,-1398.55 1370.75,-1404.43"/>
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+<!-- 2pg_c -->
+<g id="node59" class="node">
+<title>2pg_c</title>
+<ellipse fill="none" stroke="black" cx="684.29" cy="-395.02" rx="18" ry="18"/>
+<text text-anchor="middle" x="684.29" y="-391.32" font-family="Times,serif" font-size="14.00">2pg_c</text>
+</g>
+<!-- 2pg_c&#45;&gt;3pg_c -->
+<g id="edge275" class="edge">
+<title>2pg_c&#45;&gt;3pg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.06" d="M695.71,-409.1C718.59,-437.31 770.21,-500.96 797.63,-534.77"/>
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+<!-- e_17_center -->
+<g id="node60" class="node">
+<title>e_17_center</title>
+<polygon fill="none" stroke="black" points="791.89,-629.89 784.89,-629.89 784.89,-622.89 791.89,-622.89 791.89,-629.89"/>
+</g>
+<!-- 2pg_c&#45;&gt;e_17_center -->
+<g id="edge91" class="edge">
+<title>2pg_c&#45;&gt;e_17_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.06" d="M691.78,-411.66C713.5,-459.94 775.72,-598.21 786.72,-622.67"/>
+</g>
+<!-- e_17_center&#45;&gt;h2o_c -->
+<g id="edge92" class="edge">
+<title>e_17_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.06" d="M788.43,-630.03C788.57,-650.15 788.21,-749.64 768.44,-827.52 761.87,-853.4 751.13,-856.83 744.87,-882.78 741.41,-897.14 739.96,-913.51 739.41,-927.07"/>
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+</g>
+<!-- e_17_center&#45;&gt;pep_c -->
+<g id="edge93" class="edge">
+<title>e_17_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.06" d="M791.97,-627.1C817.9,-632.29 977.88,-664.27 1043.35,-677.36"/>
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+<!-- etoh_e -->
+<g id="node61" class="node">
+<title>etoh_e</title>
+<ellipse fill="none" stroke="black" cx="1316.34" cy="-1870.45" rx="18" ry="18"/>
+<text text-anchor="middle" x="1316.34" y="-1866.75" font-family="Times,serif" font-size="14.00">etoh_e</text>
+</g>
+<!-- etoh_e&#45;&gt;e_18_center -->
+<g id="edge95" class="edge">
+<title>etoh_e&#45;&gt;e_18_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1308.85,-1853.94C1281.12,-1792.84 1185.17,-1581.44 1171.08,-1550.4"/>
+</g>
+<!-- e_23_target -->
+<g id="node67" class="node">
+<title>e_23_target</title>
+<ellipse fill="black" stroke="black" cx="1426.8" cy="-2112.26" rx="1.8" ry="1.8"/>
+</g>
+<!-- etoh_e&#45;&gt;e_23_target -->
+<g id="edge102" class="edge">
+<title>etoh_e&#45;&gt;e_23_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1323.93,-1887.07C1345.04,-1933.28 1404.05,-2062.46 1421.73,-2101.16"/>
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+</g>
+<!-- e_18_center&#45;&gt;h_c -->
+<g id="edge96" class="edge">
+<title>e_18_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1166.89,-1542.84C1151.44,-1519.2 1066.34,-1387.75 1009.87,-1273.62 1000.29,-1254.26 992.82,-1230.97 987.9,-1213.23"/>
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+<!-- e_18_center&#45;&gt;etoh_c -->
+<g id="edge97" class="edge">
+<title>e_18_center&#45;&gt;etoh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1173.13,-1546.13C1193.45,-1543.69 1290.46,-1532.06 1339.38,-1526.19"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1340.09,-1529.63 1349.6,-1524.96 1339.25,-1522.68 1340.09,-1529.63"/>
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+<!-- e_24_target -->
+<g id="node68" class="node">
+<title>e_24_target</title>
+<ellipse fill="black" stroke="black" cx="1806.83" cy="-1672.53" rx="1.8" ry="1.8"/>
+</g>
+<!-- for_e -->
+<g id="node69" class="node">
+<title>for_e</title>
+<ellipse fill="none" stroke="black" cx="1583.93" cy="-1537.52" rx="18" ry="18"/>
+<text text-anchor="middle" x="1583.93" y="-1533.82" font-family="Times,serif" font-size="14.00">for_e</text>
+</g>
+<!-- for_e&#45;&gt;e_24_target -->
+<g id="edge103" class="edge">
+<title>for_e&#45;&gt;e_24_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1599.6,-1547.02C1642.34,-1572.9 1760.1,-1644.22 1796.19,-1666.08"/>
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+<!-- for_e&#45;&gt;e_41_center -->
+<g id="edge125" class="edge">
+<title>for_e&#45;&gt;e_41_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1567.28,-1530.36C1507.73,-1504.76 1307.29,-1418.57 1277.86,-1405.92"/>
+</g>
+<!-- e_25_target -->
+<g id="node70" class="node">
+<title>e_25_target</title>
+<ellipse fill="black" stroke="black" cx="1605.33" cy="-1.81" rx="1.8" ry="1.8"/>
+</g>
+<!-- fru_e -->
+<g id="node71" class="node">
+<title>fru_e</title>
+<ellipse fill="none" stroke="black" cx="1470.18" cy="-219.74" rx="18" ry="18"/>
+<text text-anchor="middle" x="1470.18" y="-216.04" font-family="Times,serif" font-size="14.00">fru_e</text>
+</g>
+<!-- fru_e&#45;&gt;e_25_target -->
+<g id="edge104" class="edge">
+<title>fru_e&#45;&gt;e_25_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1479.68,-204.42C1505.59,-162.63 1577,-47.5 1598.88,-12.22"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1601.96,-13.88 1604.26,-3.54 1596.02,-10.19 1601.96,-13.88"/>
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+<!-- fru_e&#45;&gt;e_44_center -->
+<g id="edge134" class="edge">
+<title>fru_e&#45;&gt;e_44_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1460.04,-235.13C1422.52,-292.1 1292.69,-489.2 1273.62,-518.15"/>
+</g>
+<!-- e_26_target -->
+<g id="node72" class="node">
+<title>e_26_target</title>
+<ellipse fill="black" stroke="black" cx="946.12" cy="-2215.71" rx="1.8" ry="1.8"/>
+</g>
+<!-- fum_e -->
+<g id="node73" class="node">
+<title>fum_e</title>
+<ellipse fill="none" stroke="black" cx="949.94" cy="-1951.54" rx="18" ry="18"/>
+<text text-anchor="middle" x="949.94" y="-1947.84" font-family="Times,serif" font-size="14.00">fum_e</text>
+</g>
+<!-- fum_e&#45;&gt;e_26_target -->
+<g id="edge105" class="edge">
+<title>fum_e&#45;&gt;e_26_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M949.68,-1969.7C948.95,-2020.19 946.91,-2161.31 946.3,-2203.59"/>
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+<!-- fum_e&#45;&gt;e_46_center -->
+<g id="edge142" class="edge">
+<title>fum_e&#45;&gt;e_46_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M950.19,-1933.28C951.13,-1865.38 954.39,-1629.77 954.84,-1596.97"/>
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+<!-- e_27_target -->
+<g id="node74" class="node">
+<title>e_27_target</title>
+<ellipse fill="black" stroke="black" cx="1813.63" cy="-190.22" rx="1.8" ry="1.8"/>
+</g>
+<!-- glc__D_e -->
+<g id="node75" class="node">
+<title>glc__D_e</title>
+<ellipse fill="none" stroke="black" cx="1625.01" cy="-356.6" rx="18" ry="18"/>
+<text text-anchor="middle" x="1625.01" y="-352.9" font-family="Times,serif" font-size="14.00">glc__D_e</text>
+</g>
+<!-- glc__D_e&#45;&gt;e_27_target -->
+<g id="edge106" class="edge">
+<title>glc__D_e&#45;&gt;e_27_target</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.3" d="M1638.57,-344.64C1674.84,-312.64 1773.39,-225.71 1804.25,-198.48"/>
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+<!-- glc__D_e&#45;&gt;e_49_center -->
+<g id="edge156" class="edge">
+<title>glc__D_e&#45;&gt;e_49_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.3" d="M1611.3,-368.44C1560.77,-412.08 1386.47,-562.6 1359.54,-585.86"/>
+</g>
+<!-- e_28_target -->
+<g id="node76" class="node">
+<title>e_28_target</title>
+<ellipse fill="black" stroke="black" cx="2.04" cy="-878.13" rx="1.8" ry="1.8"/>
+</g>
+<!-- gln__L_e -->
+<g id="node77" class="node">
+<title>gln__L_e</title>
+<ellipse fill="none" stroke="black" cx="273.2" cy="-924.58" rx="18" ry="18"/>
+<text text-anchor="middle" x="273.2" y="-920.88" font-family="Times,serif" font-size="14.00">gln__L_e</text>
+</g>
+<!-- gln__L_e&#45;&gt;e_28_target -->
+<g id="edge107" class="edge">
+<title>gln__L_e&#45;&gt;e_28_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M255.57,-928.38C242.95,-930.67 225.53,-932.96 210.13,-931.9 133.26,-926.61 45.01,-894.87 13.75,-882.79"/>
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+<!-- gln__L_e&#45;&gt;e_51_center -->
+<g id="edge168" class="edge">
+<title>gln__L_e&#45;&gt;e_51_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M291.19,-927.67C360.11,-939.52 605.15,-981.64 637.39,-987.18"/>
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+<!-- e_29_target -->
+<g id="node78" class="node">
+<title>e_29_target</title>
+<ellipse fill="black" stroke="black" cx="90.58" cy="-1518.57" rx="1.8" ry="1.8"/>
+</g>
+<!-- glu__L_e -->
+<g id="node79" class="node">
+<title>glu__L_e</title>
+<ellipse fill="none" stroke="black" cx="341.5" cy="-1426.3" rx="18" ry="18"/>
+<text text-anchor="middle" x="341.5" y="-1422.6" font-family="Times,serif" font-size="14.00">glu__L_e</text>
+</g>
+<!-- glu__L_e&#45;&gt;e_29_target -->
+<g id="edge108" class="edge">
+<title>glu__L_e&#45;&gt;e_29_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M324.25,-1432.64C276.3,-1450.28 142.25,-1499.57 102.09,-1514.34"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="100.76,-1511.1 92.58,-1517.83 103.17,-1517.67 100.76,-1511.1"/>
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+<!-- glu__L_e&#45;&gt;e_55_center -->
+<g id="edge192" class="edge">
+<title>glu__L_e&#45;&gt;e_55_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M357.26,-1417.04C397.3,-1393.99 506.81,-1333.82 606.1,-1305.32 639.59,-1295.71 681.69,-1290.76 694.04,-1289.45"/>
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+<!-- e_31_target -->
+<g id="node81" class="node">
+<title>e_31_target</title>
+<ellipse fill="black" stroke="black" cx="130.13" cy="-633.94" rx="1.8" ry="1.8"/>
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+<!-- h2o_e -->
+<g id="node82" class="node">
+<title>h2o_e</title>
+<ellipse fill="none" stroke="black" cx="369.19" cy="-756.71" rx="18" ry="18"/>
+<text text-anchor="middle" x="369.19" y="-753.01" font-family="Times,serif" font-size="14.00">h2o_e</text>
+</g>
+<!-- h2o_e&#45;&gt;h2o_c -->
+<g id="edge200" class="edge">
+<title>h2o_e&#45;&gt;h2o_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.4" d="M385.87,-764.24C436.62,-787.41 593.12,-860.63 714.08,-936.57 715.01,-937.15 715.95,-937.75 716.89,-938.38"/>
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+<!-- h2o_e&#45;&gt;e_31_target -->
+<g id="edge110" class="edge">
+<title>h2o_e&#45;&gt;e_31_target</title>
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+<!-- e_33_target -->
+<g id="node84" class="node">
+<title>e_33_target</title>
+<ellipse fill="black" stroke="black" cx="1235.71" cy="-2122.97" rx="1.8" ry="1.8"/>
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+<!-- mal__L_e -->
+<g id="node85" class="node">
+<title>mal__L_e</title>
+<ellipse fill="none" stroke="black" cx="1175.85" cy="-1863.61" rx="18" ry="18"/>
+<text text-anchor="middle" x="1175.85" y="-1859.91" font-family="Times,serif" font-size="14.00">mal__L_e</text>
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+<!-- mal__L_e&#45;&gt;e_33_target -->
+<g id="edge112" class="edge">
+<title>mal__L_e&#45;&gt;e_33_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1179.97,-1881.43C1191.41,-1931 1223.38,-2069.56 1232.96,-2111.07"/>
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+<!-- mal__L_e&#45;&gt;e_62_center -->
+<g id="edge221" class="edge">
+<title>mal__L_e&#45;&gt;e_62_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1171.64,-1845.96C1155.98,-1780.36 1101.64,-1552.7 1094.08,-1521.01"/>
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+<!-- e_34_target -->
+<g id="node86" class="node">
+<title>e_34_target</title>
+<ellipse fill="black" stroke="black" cx="66.3" cy="-299" rx="1.8" ry="1.8"/>
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+<!-- nh4_e -->
+<g id="node87" class="node">
+<title>nh4_e</title>
+<ellipse fill="none" stroke="black" cx="258.33" cy="-464.09" rx="18" ry="18"/>
+<text text-anchor="middle" x="258.33" y="-460.39" font-family="Times,serif" font-size="14.00">nh4_e</text>
+</g>
+<!-- nh4_e&#45;&gt;e_34_target -->
+<g id="edge113" class="edge">
+<title>nh4_e&#45;&gt;e_34_target</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.9" d="M244.52,-452.21C207.44,-420.33 106.39,-333.46 75.43,-306.85"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.9" points="77.68,-304.17 67.82,-300.31 73.12,-309.48 77.68,-304.17"/>
+</g>
+<!-- nh4_c -->
+<g id="node114" class="node">
+<title>nh4_c</title>
+<ellipse fill="none" stroke="black" cx="555.07" cy="-722.65" rx="18" ry="18"/>
+<text text-anchor="middle" x="555.07" y="-718.95" font-family="Times,serif" font-size="14.00">nh4_c</text>
+</g>
+<!-- nh4_e&#45;&gt;nh4_c -->
+<g id="edge249" class="edge">
+<title>nh4_e&#45;&gt;nh4_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.9" d="M272.25,-476.21C319.75,-517.61 475.78,-653.56 533.42,-703.79"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.9" points="531.34,-706.62 541.18,-710.55 535.94,-701.35 531.34,-706.62"/>
+</g>
+<!-- e_35_target -->
+<g id="node88" class="node">
+<title>e_35_target</title>
+<ellipse fill="black" stroke="black" cx="126.79" cy="-2226.11" rx="1.8" ry="1.8"/>
+</g>
+<!-- o2_e -->
+<g id="node89" class="node">
+<title>o2_e</title>
+<ellipse fill="none" stroke="black" cx="273.55" cy="-2032.72" rx="18" ry="18"/>
+<text text-anchor="middle" x="273.55" y="-2029.02" font-family="Times,serif" font-size="14.00">o2_e</text>
+</g>
+<!-- o2_e&#45;&gt;o2_c -->
+<g id="edge250" class="edge">
+<title>o2_e&#45;&gt;o2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.85" d="M284.32,-2017.97C320.29,-1968.7 436.45,-1809.6 480.11,-1749.81"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.85" points="483.77,-1751.99 486.24,-1741.41 476.92,-1746.99 483.77,-1751.99"/>
+</g>
+<!-- o2_e&#45;&gt;e_35_target -->
+<g id="edge114" class="edge">
+<title>o2_e&#45;&gt;e_35_target</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.4" d="M262.52,-2047.26C233.89,-2084.98 157.83,-2185.22 134.02,-2216.59"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.4" points="131.2,-2214.52 127.94,-2224.6 136.78,-2218.75 131.2,-2214.52"/>
+</g>
+<!-- e_36_target -->
+<g id="node90" class="node">
+<title>e_36_target</title>
+<ellipse fill="black" stroke="black" cx="200.78" cy="-1664.16" rx="1.8" ry="1.8"/>
+</g>
+<!-- pi_e -->
+<g id="node91" class="node">
+<title>pi_e</title>
+<ellipse fill="none" stroke="black" cx="431.69" cy="-1516.19" rx="18" ry="18"/>
+<text text-anchor="middle" x="431.69" y="-1512.49" font-family="Times,serif" font-size="14.00">pi_e</text>
+</g>
+<!-- pi_e&#45;&gt;e_36_target -->
+<g id="edge115" class="edge">
+<title>pi_e&#45;&gt;e_36_target</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.25" d="M416.18,-1526.13C372.38,-1554.19 248.54,-1633.55 211.42,-1657.34"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.25" points="209.16,-1654.63 202.63,-1662.97 212.94,-1660.52 209.16,-1654.63"/>
+</g>
+<!-- pi_e&#45;&gt;e_77_center -->
+<g id="edge277" class="edge">
+<title>pi_e&#45;&gt;e_77_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.25" d="M446.86,-1505.98C504.02,-1467.53 704.59,-1332.6 734.04,-1312.78"/>
+</g>
+<!-- e_37_target -->
+<g id="node92" class="node">
+<title>e_37_target</title>
+<ellipse fill="black" stroke="black" cx="1917.12" cy="-1245.63" rx="1.8" ry="1.8"/>
+</g>
+<!-- pyr_e -->
+<g id="node93" class="node">
+<title>pyr_e</title>
+<ellipse fill="none" stroke="black" cx="1657.9" cy="-1228.74" rx="18" ry="18"/>
+<text text-anchor="middle" x="1657.9" y="-1225.04" font-family="Times,serif" font-size="14.00">pyr_e</text>
+</g>
+<!-- pyr_e&#45;&gt;e_37_target -->
+<g id="edge116" class="edge">
+<title>pyr_e&#45;&gt;e_37_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1676.13,-1229.92C1725.94,-1233.17 1863.37,-1242.12 1905.01,-1244.84"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1904.86,-1248.33 1915.07,-1245.49 1905.31,-1241.35 1904.86,-1248.33"/>
+</g>
+<!-- pyr_e&#45;&gt;e_83_center -->
+<g id="edge308" class="edge">
+<title>pyr_e&#45;&gt;e_83_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1639.8,-1227.41C1570.45,-1222.32 1323.86,-1204.21 1291.41,-1201.83"/>
+</g>
+<!-- e_38_target -->
+<g id="node94" class="node">
+<title>e_38_target</title>
+<ellipse fill="black" stroke="black" cx="784.72" cy="-2052.99" rx="1.8" ry="1.8"/>
+</g>
+<!-- succ_e -->
+<g id="node95" class="node">
+<title>succ_e</title>
+<ellipse fill="none" stroke="black" cx="845.07" cy="-1785.55" rx="18" ry="18"/>
+<text text-anchor="middle" x="845.07" y="-1781.85" font-family="Times,serif" font-size="14.00">succ_e</text>
+</g>
+<!-- succ_e&#45;&gt;e_38_target -->
+<g id="edge117" class="edge">
+<title>succ_e&#45;&gt;e_38_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M841.02,-1803.51C829.55,-1854.35 797.06,-1998.29 787.44,-2040.94"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="783.99,-2040.32 785.21,-2050.84 790.82,-2041.86 783.99,-2040.32"/>
+</g>
+<!-- succ_e&#45;&gt;e_86_center -->
+<g id="edge313" class="edge">
+<title>succ_e&#45;&gt;e_86_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M849.09,-1767.76C861.39,-1713.26 898.09,-1550.66 904.03,-1524.35"/>
+</g>
+<!-- fdp_c -->
+<g id="node96" class="node">
+<title>fdp_c</title>
+<ellipse fill="none" stroke="black" cx="840.62" cy="-486.8" rx="18" ry="18"/>
+<text text-anchor="middle" x="840.62" y="-483.1" font-family="Times,serif" font-size="14.00">fdp_c</text>
+</g>
+<!-- e_39_center -->
+<g id="node98" class="node">
+<title>e_39_center</title>
+<polygon fill="none" stroke="black" points="885.53,-271.53 878.53,-271.53 878.53,-264.53 885.53,-264.53 885.53,-271.53"/>
+</g>
+<!-- fdp_c&#45;&gt;e_39_center -->
+<g id="edge118" class="edge">
+<title>fdp_c&#45;&gt;e_39_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.77" d="M844.01,-468.9C852.97,-421.55 876.91,-295.05 881.32,-271.75"/>
+</g>
+<!-- fdp_c&#45;&gt;e_40_center -->
+<g id="edge122" class="edge">
+<title>fdp_c&#45;&gt;e_40_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M839.94,-505.13C838.17,-552.92 833.5,-679.23 832.64,-702.49"/>
+</g>
+<!-- dhap_c -->
+<g id="node97" class="node">
+<title>dhap_c</title>
+<ellipse fill="none" stroke="black" cx="939.41" cy="-160.01" rx="18" ry="18"/>
+<text text-anchor="middle" x="939.41" y="-156.31" font-family="Times,serif" font-size="14.00">dhap_c</text>
+</g>
+<!-- dhap_c&#45;&gt;g3p_c -->
+<g id="edge349" class="edge">
+<title>dhap_c&#45;&gt;g3p_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.77" d="M943.33,-177.86C954.38,-228.14 985.83,-371.25 999.17,-431.95"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="0.77" points="995.8,-432.94 1001.37,-441.95 1002.64,-431.44 995.8,-432.94"/>
+</g>
+<!-- e_39_center&#45;&gt;g3p_c -->
+<g id="edge120" class="edge">
+<title>e_39_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.77" d="M884.38,-271.69C897.32,-291.83 960.4,-389.93 989.94,-435.88"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="0.77" points="987.03,-437.82 995.38,-444.33 992.92,-434.03 987.03,-437.82"/>
+</g>
+<!-- e_39_center&#45;&gt;dhap_c -->
+<g id="edge119" class="edge">
+<title>e_39_center&#45;&gt;dhap_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.77" d="M883.94,-264.44C890.41,-252.25 911.9,-211.8 926.15,-184.96"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="0.77" points="929.26,-186.58 930.86,-176.11 923.07,-183.3 929.26,-186.58"/>
+</g>
+<!-- e_40_center&#45;&gt;pi_c -->
+<g id="edge123" class="edge">
+<title>e_40_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M832.49,-710.11C832.42,-736.51 831.99,-889.82 831.81,-954.07"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="828.31,-954.28 831.79,-964.29 835.31,-954.3 828.31,-954.28"/>
+</g>
+<!-- e_40_center&#45;&gt;f6p_c -->
+<g id="edge124" class="edge">
+<title>e_40_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M836.07,-703.43C857.31,-686.91 967.68,-601.02 1015.74,-563.63"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1017.94,-566.34 1023.69,-557.44 1013.65,-560.82 1017.94,-566.34"/>
+</g>
+<!-- for_c -->
+<g id="node100" class="node">
+<title>for_c</title>
+<ellipse fill="none" stroke="black" cx="1470.76" cy="-1343.74" rx="18" ry="18"/>
+<text text-anchor="middle" x="1470.76" y="-1340.04" font-family="Times,serif" font-size="14.00">for_c</text>
+</g>
+<!-- for_c&#45;&gt;for_e -->
+<g id="edge129" class="edge">
+<title>for_c&#45;&gt;for_e</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1480.02,-1359.6C1499.76,-1393.39 1546.07,-1472.71 1569.63,-1513.04"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1566.63,-1514.85 1574.7,-1521.72 1572.67,-1511.32 1566.63,-1514.85"/>
+</g>
+<!-- e_41_center&#45;&gt;h_c -->
+<g id="edge128" class="edge">
+<title>e_41_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1270.54,-1401.6C1242.81,-1380.93 1067.16,-1249.94 1003.81,-1202.71"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1005.75,-1199.79 995.64,-1196.62 1001.57,-1205.4 1005.75,-1199.79"/>
+</g>
+<!-- e_41_center&#45;&gt;for_c -->
+<g id="edge127" class="edge">
+<title>e_41_center&#45;&gt;for_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1277.92,-1403.16C1292.44,-1398.41 1347.27,-1380.54 1392.67,-1366.66 1409.57,-1361.49 1428.61,-1355.9 1443.65,-1351.53"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1444.72,-1354.86 1453.36,-1348.72 1442.78,-1348.14 1444.72,-1354.86"/>
+</g>
+<!-- fum_c -->
+<g id="node102" class="node">
+<title>fum_c</title>
+<ellipse fill="none" stroke="black" cx="779.73" cy="-1615.73" rx="18" ry="18"/>
+<text text-anchor="middle" x="779.73" y="-1612.03" font-family="Times,serif" font-size="14.00">fum_c</text>
+</g>
+<!-- fum_c&#45;&gt;e_43_center -->
+<g id="edge131" class="edge">
+<title>fum_c&#45;&gt;e_43_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M767.97,-1629.64C750.26,-1650.57 717.76,-1688.99 707.57,-1701.04"/>
+</g>
+<!-- fum_c&#45;&gt;e_45_center -->
+<g id="edge139" class="edge">
+<title>fum_c&#45;&gt;e_45_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M782.81,-1597.81C793.3,-1536.88 827.2,-1339.81 832.18,-1310.89"/>
+</g>
+<!-- succ_c -->
+<g id="node103" class="node">
+<title>succ_c</title>
+<ellipse fill="none" stroke="black" cx="706.39" cy="-1491.69" rx="18" ry="18"/>
+<text text-anchor="middle" x="706.39" y="-1487.99" font-family="Times,serif" font-size="14.00">succ_c</text>
+</g>
+<!-- succ_c&#45;&gt;e_87_center -->
+<g id="edge318" class="edge">
+<title>succ_c&#45;&gt;e_87_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M724.36,-1493.42C763.45,-1497.2 854.24,-1505.99 873.63,-1507.86"/>
+</g>
+<!-- succ_c&#45;&gt;e_88_center -->
+<g id="edge322" class="edge">
+<title>succ_c&#45;&gt;e_88_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M702.5,-1509.47C693.24,-1551.75 670.34,-1656.29 665.78,-1677.09"/>
+</g>
+<!-- succ_c&#45;&gt;e_89_center -->
+<g id="edge327" class="edge">
+<title>succ_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M710.46,-1474.03C715.7,-1451.77 725.31,-1412.41 735.25,-1379.19 760.95,-1293.36 799.23,-1190.53 807.02,-1169.79"/>
+</g>
+<!-- e_43_center&#45;&gt;q8_c -->
+<g id="edge132" class="edge">
+<title>e_43_center&#45;&gt;q8_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M705.89,-1701.19C712.27,-1685.65 737.96,-1623.02 752.81,-1586.82"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="756.13,-1587.95 756.69,-1577.37 749.65,-1585.29 756.13,-1587.95"/>
+</g>
+<!-- e_43_center&#45;&gt;succ_c -->
+<g id="edge133" class="edge">
+<title>e_43_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M704.47,-1701.05C704.66,-1679.8 705.65,-1572.31 706.13,-1520.16"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="709.63,-1519.95 706.23,-1509.92 702.63,-1519.89 709.63,-1519.95"/>
+</g>
+<!-- e_44_center&#45;&gt;f6p_c -->
+<g id="edge137" class="edge">
+<title>e_44_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1267.62,-522.09C1244.87,-524.48 1122.02,-537.38 1066.01,-543.27"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1065.63,-539.79 1056.05,-544.31 1066.36,-546.75 1065.63,-539.79"/>
+</g>
+<!-- e_44_center&#45;&gt;pyr_c -->
+<g id="edge136" class="edge">
+<title>e_44_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1270.65,-525.24C1265.27,-555.55 1226.75,-772.43 1212.84,-850.77"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1209.35,-850.42 1211.04,-860.87 1216.24,-851.64 1209.35,-850.42"/>
+</g>
+<!-- mal__L_c -->
+<g id="node106" class="node">
+<title>mal__L_c</title>
+<ellipse fill="none" stroke="black" cx="1099.9" cy="-1247.54" rx="18" ry="18"/>
+<text text-anchor="middle" x="1099.9" y="-1243.84" font-family="Times,serif" font-size="14.00">mal__L_c</text>
+</g>
+<!-- mal__L_c&#45;&gt;e_63_center -->
+<g id="edge225" class="edge">
+<title>mal__L_c&#45;&gt;e_63_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1094.2,-1230.31C1088.25,-1212.28 1079.32,-1185.24 1076.06,-1175.37"/>
+</g>
+<!-- mal__L_c&#45;&gt;e_64_center -->
+<g id="edge230" class="edge">
+<title>mal__L_c&#45;&gt;e_64_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1112.62,-1234.51C1150.95,-1195.26 1264.01,-1079.51 1285.73,-1057.27"/>
+</g>
+<!-- mal__L_c&#45;&gt;e_65_center -->
+<g id="edge235" class="edge">
+<title>mal__L_c&#45;&gt;e_65_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1108.7,-1231.55C1124.77,-1202.72 1160.38,-1140.39 1194.83,-1090.68 1216.01,-1060.11 1245.01,-1025.77 1254.36,-1014.87"/>
+</g>
+<!-- e_45_center&#45;&gt;mal__L_c -->
+<g id="edge140" class="edge">
+<title>e_45_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M836.5,-1307.13C856.16,-1305.98 950.06,-1299.6 1023.72,-1279.4 1030.15,-1277.63 1031.44,-1276.25 1037.59,-1273.69 1049.57,-1268.71 1062.83,-1263.16 1074.03,-1258.45"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1075.39,-1261.67 1083.25,-1254.57 1072.67,-1255.22 1075.39,-1261.67"/>
+</g>
+<!-- e_46_center&#45;&gt;h_c -->
+<g id="edge143" class="edge">
+<title>e_46_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M954.99,-1589.53C955.61,-1566.56 959.27,-1439.18 966.62,-1335.58 969.63,-1293.09 974.67,-1243.98 977.93,-1213.89"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="981.43,-1214.04 979.04,-1203.72 974.47,-1213.28 981.43,-1214.04"/>
+</g>
+<!-- e_46_center&#45;&gt;fum_c -->
+<g id="edge144" class="edge">
+<title>e_46_center&#45;&gt;fum_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M951.24,-1593.64C933.04,-1595.98 851.39,-1606.5 807.64,-1612.13"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="807.11,-1608.67 797.64,-1613.42 808.01,-1615.61 807.11,-1608.67"/>
+</g>
+<!-- 6pgl_c -->
+<g id="node109" class="node">
+<title>6pgl_c</title>
+<ellipse fill="none" stroke="black" cx="1349.81" cy="-807.12" rx="18" ry="18"/>
+<text text-anchor="middle" x="1349.81" y="-803.42" font-family="Times,serif" font-size="14.00">6pgl_c</text>
+</g>
+<!-- 6pgl_c&#45;&gt;e_75_center -->
+<g id="edge272" class="edge">
+<title>6pgl_c&#45;&gt;e_75_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1332.2,-812.74C1302.98,-822.26 1242.89,-842.71 1194.07,-864.96 1170.64,-875.65 1165.81,-880.45 1142.39,-891.18 1136.33,-893.96 1135.07,-895.66 1128.52,-896.88 1115.81,-899.24 1100.36,-897.57 1093.43,-896.59"/>
+</g>
+<!-- e_47_center&#45;&gt;h_c -->
+<g id="edge148" class="edge">
+<title>e_47_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1202.24,-921.18C1190.06,-939.4 1135.06,-1020.72 1082.98,-1081.74 1056.64,-1112.6 1023.27,-1145.65 1002.04,-1166.01"/>
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+</g>
+<!-- e_47_center&#45;&gt;nadph_c -->
+<g id="edge149" class="edge">
+<title>e_47_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1201.11,-917.64C1193.41,-918.04 1174.74,-919 1158.46,-919.83"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.75" points="1158.02,-915.7 1148.24,-920.36 1158.45,-924 1158.02,-915.7"/>
+</g>
+<!-- e_47_center&#45;&gt;6pgl_c -->
+<g id="edge147" class="edge">
+<title>e_47_center&#45;&gt;6pgl_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1208.48,-915.58C1218.88,-910.35 1248.7,-894.83 1271.13,-878.34 1292.37,-862.73 1314.44,-842.32 1329.78,-827.36"/>
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+</g>
+<!-- 13dpg_c -->
+<g id="node111" class="node">
+<title>13dpg_c</title>
+<ellipse fill="none" stroke="black" cx="904.29" cy="-601.16" rx="18" ry="18"/>
+<text text-anchor="middle" x="904.29" y="-597.46" font-family="Times,serif" font-size="14.00">13dpg_c</text>
+</g>
+<!-- e_48_center&#45;&gt;h_c -->
+<g id="edge154" class="edge">
+<title>e_48_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.27" d="M1022.72,-851.09C1018.97,-881.2 993.98,-1082 984.61,-1157.3"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.27" points="981.11,-1157.11 983.34,-1167.46 988.05,-1157.97 981.11,-1157.11"/>
+</g>
+<!-- e_48_center&#45;&gt;nadh_c -->
+<g id="edge153" class="edge">
+<title>e_48_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.27" d="M1025.66,-851.09C1040.34,-873.75 1116.66,-991.52 1149.89,-1042.8"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.27" points="1147.01,-1044.8 1155.38,-1051.29 1152.88,-1040.99 1147.01,-1044.8"/>
+</g>
+<!-- e_48_center&#45;&gt;13dpg_c -->
+<g id="edge155" class="edge">
+<title>e_48_center&#45;&gt;13dpg_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.27" d="M1021.32,-843.42C1009.45,-818.85 944.15,-683.67 916.58,-626.6"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.27" points="919.69,-625 912.19,-617.52 913.39,-628.05 919.69,-625"/>
+</g>
+<!-- e_49_center&#45;&gt;pyr_c -->
+<g id="edge158" class="edge">
+<title>e_49_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.3" d="M1354.16,-592.55C1340.36,-619.56 1254.08,-788.41 1220.86,-853.43"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.3" points="1217.61,-852.09 1216.18,-862.59 1223.85,-855.28 1217.61,-852.09"/>
+</g>
+<!-- e_49_center&#45;&gt;g6p_c -->
+<g id="edge159" class="edge">
+<title>e_49_center&#45;&gt;g6p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.3" d="M1352.39,-590.75C1335.12,-599.56 1260.82,-637.5 1221.06,-657.8"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.3" points="1219.29,-654.77 1211.98,-662.44 1222.48,-661.01 1219.29,-654.77"/>
+</g>
+<!-- nh4_c&#45;&gt;e_50_center -->
+<g id="edge161" class="edge">
+<title>nh4_c&#45;&gt;e_50_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.4" d="M565.3,-737.47C596.38,-782.49 688.59,-916.04 704.9,-939.67"/>
+</g>
+<!-- e_50_center&#45;&gt;h_c -->
+<g id="edge165" class="edge">
+<title>e_50_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.4" d="M709.18,-947.11C711.95,-952.66 717.74,-962.93 725.38,-969.14 743.8,-984.1 755.85,-974 775.68,-987.03 854.84,-1039.06 930.16,-1124.01 963.34,-1163.84"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.4" points="960.71,-1166.14 969.77,-1171.63 966.11,-1161.69 960.71,-1166.14"/>
+</g>
+<!-- e_50_center&#45;&gt;adp_c -->
+<g id="edge164" class="edge">
+<title>e_50_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.4" d="M711.11,-942.23C717.07,-940.62 729.13,-937.51 739.54,-935.81 750.82,-933.96 763.34,-932.61 774.22,-931.65"/>
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+</g>
+<!-- e_50_center&#45;&gt;pi_c -->
+<g id="edge163" class="edge">
+<title>e_50_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.4" d="M711.09,-941.61C717.02,-939.15 729.03,-934.89 739.54,-935.81 765.25,-938.04 791.19,-952.49 808.98,-964.7"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.4" points="807.32,-967.83 817.49,-970.81 811.41,-962.14 807.32,-967.83"/>
+</g>
+<!-- e_50_center&#45;&gt;gln__L_c -->
+<g id="edge166" class="edge">
+<title>e_50_center&#45;&gt;gln__L_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.4" d="M708.67,-939.67C713.24,-926.89 728.99,-882.89 739.36,-853.91"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.4" points="742.7,-854.97 742.77,-844.37 736.11,-852.61 742.7,-854.97"/>
+</g>
+<!-- e_51_center&#45;&gt;h_c -->
+<g id="edge172" class="edge">
+<title>e_51_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M644.77,-989.42C663.66,-997.48 748.12,-1034.08 813.19,-1071.78 866.97,-1102.93 926.35,-1145.27 958.07,-1168.59"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="956.14,-1171.51 966.26,-1174.63 960.3,-1165.88 956.14,-1171.51"/>
+</g>
+<!-- e_51_center&#45;&gt;adp_c -->
+<g id="edge171" class="edge">
+<title>e_51_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M644.67,-986.1C655.68,-981.12 688.59,-965.84 714.08,-949.97 719.5,-946.59 720.06,-944.54 725.63,-941.42 731.45,-938.16 733.06,-937.39 739.54,-935.81 750.64,-933.09 763.13,-931.57 774.03,-930.73"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="774.53,-934.21 784.29,-930.1 774.1,-927.22 774.53,-934.21"/>
+</g>
+<!-- e_51_center&#45;&gt;pi_c -->
+<g id="edge170" class="edge">
+<title>e_51_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M644.66,-987.48C659.52,-986.33 715.58,-982.15 761.83,-981.27 775.58,-981.01 790.85,-981.2 803.6,-981.49"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="803.54,-984.99 813.63,-981.75 803.72,-977.99 803.54,-984.99"/>
+</g>
+<!-- e_51_center&#45;&gt;gln__L_c -->
+<g id="edge173" class="edge">
+<title>e_51_center&#45;&gt;gln__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M643.36,-984.13C655.15,-966.61 706.48,-890.35 732.93,-851.04"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="736.1,-852.6 738.78,-842.35 730.3,-848.69 736.1,-852.6"/>
+</g>
+<!-- e_52_center&#45;&gt;h_c -->
+<g id="edge179" class="edge">
+<title>e_52_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.82" d="M881.56,-923.1C891.25,-948.69 947.74,-1097.77 971.03,-1159.25"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.82" points="967.78,-1160.56 974.6,-1168.67 974.33,-1158.08 967.78,-1160.56"/>
+</g>
+<!-- e_52_center&#45;&gt;akg_c -->
+<g id="edge177" class="edge">
+<title>e_52_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.82" d="M883.71,-920.67C894.13,-924.6 925.31,-936.78 949.34,-950.48 968.86,-961.61 973.91,-964.63 990.68,-979.58 1013.63,-1000.06 1036.66,-1026.83 1051.78,-1045.48"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.82" points="1049.17,-1047.81 1058.15,-1053.43 1054.63,-1043.44 1049.17,-1047.81"/>
+</g>
+<!-- e_52_center&#45;&gt;nadph_c -->
+<g id="edge180" class="edge">
+<title>e_52_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.82" d="M883.78,-919.64C898.21,-920.8 952.64,-925.03 997.54,-926.37 1033.53,-927.45 1075.01,-925.32 1101.82,-923.49"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.82" points="1102.3,-926.97 1112.02,-922.76 1101.8,-919.98 1102.3,-926.97"/>
+</g>
+<!-- e_52_center&#45;&gt;nh4_c -->
+<g id="edge178" class="edge">
+<title>e_52_center&#45;&gt;nh4_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.82" d="M876.48,-917.52C859.86,-909.24 789.97,-874.07 734.9,-841.2 677.43,-806.88 612.4,-762.6 578.49,-739.06"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.82" points="580.38,-736.11 570.17,-733.27 576.38,-741.86 580.38,-736.11"/>
+</g>
+<!-- e_53_center&#45;&gt;glu__L_c -->
+<g id="edge184" class="edge">
+<title>e_53_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M590.84,-849.76C605.19,-863.28 656.76,-911.65 700.68,-949.97 713.41,-961.07 727.93,-973.18 739.62,-982.81"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="737.62,-985.69 747.57,-989.33 742.06,-980.28 737.62,-985.69"/>
+</g>
+<!-- e_53_center&#45;&gt;nh4_c -->
+<g id="edge183" class="edge">
+<title>e_53_center&#45;&gt;nh4_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M586.05,-842.55C582.6,-829.19 570.22,-781.27 562.19,-750.2"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="565.54,-749.2 559.65,-740.39 558.77,-750.95 565.54,-749.2"/>
+</g>
+<!-- e_54_center&#45;&gt;glu__L_c -->
+<g id="edge190" class="edge">
+<title>e_54_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M938.98,-959.3C925.37,-967.04 876.23,-993.7 831.71,-1001.99 818.1,-1004.52 802.74,-1004.57 789.89,-1003.86"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="790.01,-1000.36 779.78,-1003.11 789.5,-1007.34 790.01,-1000.36"/>
+</g>
+<!-- e_54_center&#45;&gt;nadp_c -->
+<g id="edge189" class="edge">
+<title>e_54_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M946.38,-955.58C956.71,-951.12 986.57,-938.12 1010.94,-926.37 1043.4,-910.72 1049.41,-902.23 1083.05,-889.31 1088.58,-887.19 1094.63,-885.3 1100.46,-883.69"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1101.75,-886.97 1110.56,-881.09 1100.01,-880.19 1101.75,-886.97"/>
+</g>
+<!-- e_55_center&#45;&gt;h_c -->
+<g id="edge193" class="edge">
+<title>e_55_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M701.17,-1287.78C727.33,-1278.25 889.66,-1219.07 954.43,-1195.46"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="955.75,-1198.71 963.95,-1191.99 953.36,-1192.13 955.75,-1198.71"/>
+</g>
+<!-- e_55_center&#45;&gt;glu__L_c -->
+<g id="edge194" class="edge">
+<title>e_55_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M698.39,-1285.46C703.25,-1263.58 729.18,-1146.88 750.43,-1051.68 752.09,-1044.25 753.89,-1036.2 755.56,-1028.75"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="759.03,-1029.27 757.8,-1018.74 752.2,-1027.74 759.03,-1029.27"/>
+</g>
+<!-- 6pgc_c -->
+<g id="node121" class="node">
+<title>6pgc_c</title>
+<ellipse fill="none" stroke="black" cx="1336.79" cy="-724.73" rx="18" ry="18"/>
+<text text-anchor="middle" x="1336.79" y="-721.03" font-family="Times,serif" font-size="14.00">6pgc_c</text>
+</g>
+<!-- 6pgc_c&#45;&gt;e_56_center -->
+<g id="edge195" class="edge">
+<title>6pgc_c&#45;&gt;e_56_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1322.36,-713.53C1305.94,-700.8 1280.18,-680.82 1270.75,-673.5"/>
+</g>
+<!-- xu5p__D_c -->
+<g id="node147" class="node">
+<title>xu5p__D_c</title>
+<ellipse fill="none" stroke="black" cx="1246.76" cy="-144.93" rx="18" ry="18"/>
+<text text-anchor="middle" x="1246.76" y="-141.23" font-family="Times,serif" font-size="14.00">xu5p__D_c</text>
+</g>
+<!-- ru5p__D_c&#45;&gt;xu5p__D_c -->
+<g id="edge311" class="edge">
+<title>ru5p__D_c&#45;&gt;xu5p__D_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.02" d="M1299.59,-359.42C1289.64,-319.03 1265.35,-220.39 1253.49,-172.25"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.02" points="1256.91,-171.38 1251.1,-162.52 1250.07,-173.07 1256.91,-171.38"/>
+</g>
+<!-- e_56_center&#45;&gt;co2_c -->
+<g id="edge198" class="edge">
+<title>e_56_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1266.95,-674.39C1265.95,-694.18 1261.19,-788.49 1258.77,-836.37"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.75" points="1254.62,-836.19 1258.27,-846.39 1262.92,-836.61 1254.62,-836.19"/>
+</g>
+<!-- e_56_center&#45;&gt;nadph_c -->
+<g id="edge199" class="edge">
+<title>e_56_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1265.19,-674.24C1252.03,-698.3 1175.3,-838.53 1143.65,-896.37"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.75" points="1139.96,-894.46 1138.81,-905.23 1147.25,-898.45 1139.96,-894.46"/>
+</g>
+<!-- e_56_center&#45;&gt;ru5p__D_c -->
+<g id="edge197" class="edge">
+<title>e_56_center&#45;&gt;ru5p__D_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1267.6,-666.98C1270.98,-640.02 1291.92,-473.35 1300.41,-405.72"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.75" points="1304.58,-405.83 1301.7,-395.39 1296.33,-404.8 1304.58,-405.83"/>
+</g>
+<!-- e_58_center&#45;&gt;akg_c -->
+<g id="edge204" class="edge">
+<title>e_58_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M987.64,-989.78C997.98,-999.67 1027.99,-1028.36 1048.58,-1048.05"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.26" points="1046.3,-1050.71 1055.95,-1055.1 1051.14,-1045.66 1046.3,-1050.71"/>
+</g>
+<!-- e_58_center&#45;&gt;co2_c -->
+<g id="edge203" class="edge">
+<title>e_58_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M987.59,-985.5C1005.28,-981.61 1084.24,-963.38 1143.74,-935.29 1179.38,-918.46 1188.77,-914.65 1221.61,-892.86 1226.2,-889.82 1230.93,-886.33 1235.39,-882.86"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.26" points="1237.91,-885.33 1243.52,-876.34 1233.53,-879.87 1237.91,-885.33"/>
+</g>
+<!-- e_58_center&#45;&gt;nadph_c -->
+<g id="edge205" class="edge">
+<title>e_58_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.26" d="M987.59,-984.67C1003.4,-977.64 1067.44,-949.14 1104.03,-932.86"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.26" points="1105.85,-935.88 1113.57,-928.62 1103.01,-929.48 1105.85,-935.88"/>
+</g>
+<!-- glx_c -->
+<g id="node125" class="node">
+<title>glx_c</title>
+<ellipse fill="none" stroke="black" cx="605.92" cy="-1324.92" rx="18" ry="18"/>
+<text text-anchor="middle" x="605.92" y="-1321.22" font-family="Times,serif" font-size="14.00">glx_c</text>
+</g>
+<!-- glx_c&#45;&gt;e_61_center -->
+<g id="edge215" class="edge">
+<title>glx_c&#45;&gt;e_61_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M622.26,-1316.43C673.92,-1289.56 831.84,-1207.43 857.4,-1194.13"/>
+</g>
+<!-- e_59_center&#45;&gt;succ_c -->
+<g id="edge208" class="edge">
+<title>e_59_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M521.04,-1367.22C540.9,-1380.55 637.6,-1445.49 682.9,-1475.91"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="680.98,-1478.84 691.24,-1481.51 684.89,-1473.03 680.98,-1478.84"/>
+</g>
+<!-- e_59_center&#45;&gt;glx_c -->
+<g id="edge207" class="edge">
+<title>e_59_center&#45;&gt;glx_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M521.24,-1363.08C531.23,-1358.58 558.92,-1346.1 579.94,-1336.63"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="581.65,-1339.7 589.33,-1332.4 578.77,-1333.32 581.65,-1339.7"/>
+</g>
+<!-- e_60_center&#45;&gt;h_c -->
+<g id="edge213" class="edge">
+<title>e_60_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1251.13,-1159.7C1232.62,-1161.97 1149.67,-1172.02 1081.51,-1178.29 1057.16,-1180.53 1029.43,-1182.55 1009.29,-1183.92"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1008.97,-1180.44 999.23,-1184.6 1009.44,-1187.42 1008.97,-1180.44"/>
+</g>
+<!-- e_60_center&#45;&gt;nadh_c -->
+<g id="edge212" class="edge">
+<title>e_60_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1251.2,-1156.19C1241.48,-1148.15 1214.67,-1125.46 1194.83,-1104.08 1190.59,-1099.5 1186.28,-1094.36 1182.32,-1089.4"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1184.95,-1087.09 1176.05,-1081.34 1179.43,-1091.39 1184.95,-1087.09"/>
+</g>
+<!-- e_60_center&#45;&gt;pyr_c -->
+<g id="edge211" class="edge">
+<title>e_60_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1254.31,-1155.69C1250.01,-1130.06 1223.5,-972.18 1212.56,-907.01"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1215.99,-906.31 1210.88,-897.03 1209.09,-907.47 1215.99,-906.31"/>
+</g>
+<!-- e_61_center&#45;&gt;coa_c -->
+<g id="edge217" class="edge">
+<title>e_61_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M864.42,-1190.35C880.94,-1181.16 951.77,-1141.72 990.11,-1120.37"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="992.07,-1123.29 999.1,-1115.36 988.67,-1117.17 992.07,-1123.29"/>
+</g>
+<!-- e_61_center&#45;&gt;h_c -->
+<g id="edge219" class="edge">
+<title>e_61_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M864.64,-1192.1C877.77,-1191.39 922.66,-1188.94 952.71,-1187.3"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="953.23,-1190.78 963.02,-1186.74 952.84,-1183.79 953.23,-1190.78"/>
+</g>
+<!-- e_61_center&#45;&gt;mal__L_c -->
+<g id="edge218" class="edge">
+<title>e_61_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M864.67,-1193.17C888.15,-1198.6 1015.64,-1228.07 1072.5,-1241.21"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1071.72,-1244.62 1082.26,-1243.46 1073.3,-1237.8 1071.72,-1244.62"/>
+</g>
+<!-- e_62_center&#45;&gt;h_c -->
+<g id="edge223" class="edge">
+<title>e_62_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1091.91,-1513.72C1083.72,-1490.85 1038.46,-1364.03 1004.17,-1259.75 999.11,-1244.36 993.7,-1227.09 989.39,-1213.11"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="992.61,-1211.68 986.34,-1203.14 985.92,-1213.73 992.61,-1211.68"/>
+</g>
+<!-- e_62_center&#45;&gt;mal__L_c -->
+<g id="edge222" class="edge">
+<title>e_62_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1093.3,-1513.52C1093.94,-1487.79 1097.64,-1338.67 1099.2,-1275.65"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1102.7,-1275.7 1099.45,-1265.61 1095.7,-1275.52 1102.7,-1275.7"/>
+</g>
+<!-- e_63_center&#45;&gt;h_c -->
+<g id="edge227" class="edge">
+<title>e_63_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1071.25,-1172.13C1061.14,-1173.66 1031.56,-1178.12 1009.01,-1181.53"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1008.29,-1178.1 998.93,-1183.05 1009.34,-1185.02 1008.29,-1178.1"/>
+</g>
+<!-- e_63_center&#45;&gt;nadh_c -->
+<g id="edge226" class="edge">
+<title>e_63_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1078.37,-1167.82C1090.49,-1154.99 1129.7,-1113.41 1135.01,-1107.07 1139.63,-1101.57 1144.4,-1095.45 1148.76,-1089.67"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1151.63,-1091.68 1154.78,-1081.57 1146.01,-1087.51 1151.63,-1091.68"/>
+</g>
+<!-- e_63_center&#45;&gt;oaa_c -->
+<g id="edge228" class="edge">
+<title>e_63_center&#45;&gt;oaa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1073.28,-1168.01C1068.19,-1156.33 1050.87,-1118.63 1028.98,-1092.78 1021.52,-1083.98 1016.61,-1084.88 1008.99,-1076.22 991.57,-1056.42 975.9,-1030.69 965.5,-1011.94"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="968.54,-1010.21 960.7,-1003.09 962.39,-1013.55 968.54,-1010.21"/>
+</g>
+<!-- e_64_center&#45;&gt;nadh_c -->
+<g id="edge233" class="edge">
+<title>e_64_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1285.78,-1053.93C1272.5,-1055.34 1225.17,-1060.36 1193.95,-1063.67"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1193.24,-1060.23 1183.67,-1064.76 1193.98,-1067.19 1193.24,-1060.23"/>
+</g>
+<!-- e_64_center&#45;&gt;co2_c -->
+<g id="edge231" class="edge">
+<title>e_64_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1288.75,-1049.94C1285.49,-1030.71 1270.04,-939.35 1262.09,-892.4"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1265.5,-891.57 1260.38,-882.3 1258.6,-892.74 1265.5,-891.57"/>
+</g>
+<!-- e_64_center&#45;&gt;pyr_c -->
+<g id="edge232" class="edge">
+<title>e_64_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1287.66,-1049.91C1279.04,-1031.46 1239.91,-947.61 1219.82,-904.57"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1222.9,-902.89 1215.49,-895.31 1216.55,-905.85 1222.9,-902.89"/>
+</g>
+<!-- e_65_center&#45;&gt;co2_c -->
+<g id="edge236" class="edge">
+<title>e_65_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1257.39,-1007.72C1257.39,-992.11 1257.37,-929.85 1257.36,-892.72"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1260.86,-892.53 1257.36,-882.53 1253.86,-892.53 1260.86,-892.53"/>
+</g>
+<!-- e_65_center&#45;&gt;pyr_c -->
+<g id="edge237" class="edge">
+<title>e_65_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1256.06,-1007.81C1250.71,-993.49 1230.36,-939.09 1217.87,-905.71"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1221.05,-904.23 1214.27,-896.09 1214.49,-906.68 1221.05,-904.23"/>
+</g>
+<!-- e_65_center&#45;&gt;nadph_c -->
+<g id="edge238" class="edge">
+<title>e_65_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1253.71,-1008.75C1239.17,-998.47 1184.92,-960.11 1153.3,-937.76"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1155.22,-934.83 1145.03,-931.91 1151.17,-940.54 1155.22,-934.83"/>
+</g>
+<!-- e_66_center&#45;&gt;nad_c -->
+<g id="edge242" class="edge">
+<title>e_66_center&#45;&gt;nad_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M974.68,-1338.48C978.91,-1326.71 992.25,-1289.91 1004.17,-1259.75 1006.62,-1253.55 1006.7,-1251.73 1009.94,-1245.9 1031.54,-1207.2 1042,-1200.71 1068.11,-1164.89 1080.14,-1148.4 1093.85,-1129.88 1104.33,-1115.79"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="1107.93,-1118.28 1110.4,-1107.64 1100.91,-1113.05 1107.93,-1118.28"/>
+</g>
+<!-- e_66_center&#45;&gt;h_e -->
+<g id="edge243" class="edge">
+<title>e_66_center&#45;&gt;h_e</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M974.75,-1345.94C976.21,-1349.69 978.63,-1355.88 981.17,-1362.41"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="977.2,-1364.24 984.91,-1371.97 985.35,-1361.06 977.2,-1364.24"/>
+</g>
+<!-- e_66_center&#45;&gt;q8h2_c -->
+<g id="edge244" class="edge">
+<title>e_66_center&#45;&gt;q8h2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M970.79,-1345.81C954.7,-1368.21 866.22,-1491.5 828.86,-1543.55"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="825.19,-1541.16 822.91,-1551.83 832.3,-1546.26 825.19,-1541.16"/>
+</g>
+<!-- e_67_center&#45;&gt;nadh_c -->
+<g id="edge248" class="edge">
+<title>e_67_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1294.41,-957.97C1279.3,-970.71 1219.58,-1021.03 1186.95,-1048.52"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="1184.11,-1045.2 1179.28,-1054.99 1189.75,-1051.89 1184.11,-1045.2"/>
+</g>
+<!-- e_67_center&#45;&gt;nadp_c -->
+<g id="edge247" class="edge">
+<title>e_67_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1294.39,-953.02C1282.67,-946.58 1244.26,-925.75 1211.41,-910.76 1192.83,-902.27 1171.45,-893.66 1155.07,-887.3"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="1156.48,-883.15 1145.58,-883.65 1153.34,-891.32 1156.48,-883.15"/>
+</g>
+<!-- e_70_center&#45;&gt;nadh_c -->
+<g id="edge255" class="edge">
+<title>e_70_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.7" d="M1196.1,-1000.29C1192.6,-1007.86 1184.45,-1025.46 1177.43,-1040.65"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.7" points="1174.06,-1039.6 1173.03,-1050.15 1180.41,-1042.54 1174.06,-1039.6"/>
+</g>
+<!-- e_70_center&#45;&gt;accoa_c -->
+<g id="edge256" class="edge">
+<title>e_70_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.7" d="M1194.19,-997.89C1175.83,-1004.8 1092.88,-1036.03 1049.5,-1052.36"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.7" points="1048.01,-1049.18 1039.88,-1055.98 1050.47,-1055.74 1048.01,-1049.18"/>
+</g>
+<!-- e_70_center&#45;&gt;co2_c -->
+<g id="edge254" class="edge">
+<title>e_70_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.7" d="M1199.43,-992.98C1205.93,-978.56 1230.78,-923.39 1245.74,-890.18"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.7" points="1248.94,-891.6 1249.86,-881.05 1242.56,-888.73 1248.94,-891.6"/>
+</g>
+<!-- e_71_center&#45;&gt;h_c -->
+<g id="edge261" class="edge">
+<title>e_71_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.77" d="M900.54,-788.34C901.27,-799.95 903.79,-836.25 908.27,-866.04 924.77,-975.78 958.35,-1103.77 973.44,-1158.59"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="0.77" points="970.07,-1159.55 976.11,-1168.25 976.82,-1157.68 970.07,-1159.55"/>
+</g>
+<!-- e_71_center&#45;&gt;adp_c -->
+<g id="edge260" class="edge">
+<title>e_71_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.77" d="M897.89,-788.18C887.09,-804.19 842.73,-869.94 818.46,-905.92"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="0.77" points="815.45,-904.13 812.76,-914.37 821.25,-908.04 815.45,-904.13"/>
+</g>
+<!-- e_71_center&#45;&gt;fdp_c -->
+<g id="edge259" class="edge">
+<title>e_71_center&#45;&gt;fdp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.77" d="M899.55,-780.83C894.05,-753.35 859.86,-582.82 846.23,-514.78"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="0.77" points="849.62,-513.9 844.22,-504.78 842.75,-515.27 849.62,-513.9"/>
+</g>
+<!-- e_72_center&#45;&gt;accoa_c -->
+<g id="edge265" class="edge">
+<title>e_72_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1277.86,-1120.69C1260.44,-1121.98 1182.52,-1126.69 1121.11,-1112.72 1114.61,-1111.24 1113.36,-1109.64 1107.29,-1106.88 1083.88,-1096.25 1077.91,-1093.74 1055.26,-1081.55 1052.53,-1080.08 1049.7,-1078.5 1046.9,-1076.89"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1048.61,-1073.84 1038.21,-1071.81 1045.08,-1079.88 1048.61,-1073.84"/>
+</g>
+<!-- e_72_center&#45;&gt;for_c -->
+<g id="edge264" class="edge">
+<title>e_72_center&#45;&gt;for_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1284.4,-1123.91C1303.47,-1146.41 1409.19,-1271.12 1452.38,-1322.06"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1449.85,-1324.48 1458.98,-1329.85 1455.19,-1319.96 1449.85,-1324.48"/>
+</g>
+<!-- e_74_center&#45;&gt;adp_c -->
+<g id="edge269" class="edge">
+<title>e_74_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.27" d="M742.29,-694.8C748.29,-718.25 780.88,-845.58 795.41,-902.36"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.27" points="792.03,-903.28 797.9,-912.1 798.81,-901.54 792.03,-903.28"/>
+</g>
+<!-- e_74_center&#45;&gt;13dpg_c -->
+<g id="edge270" class="edge">
+<title>e_74_center&#45;&gt;13dpg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.27" d="M745.04,-689.01C762.71,-679.26 839.19,-637.07 879.39,-614.9"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.27" points="881.24,-617.87 888.3,-609.98 877.86,-611.74 881.24,-617.87"/>
+</g>
+<!-- e_75_center&#45;&gt;h_c -->
+<g id="edge274" class="edge">
+<title>e_75_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1087,-899.88C1074.63,-917.51 1023.86,-992.41 1003.27,-1062.35 993.86,-1094.33 987.77,-1132.2 984.39,-1157.48"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.75" points="980.25,-1157.04 983.1,-1167.48 988.5,-1158.09 980.25,-1157.04"/>
+</g>
+<!-- e_75_center&#45;&gt;6pgc_c -->
+<g id="edge273" class="edge">
+<title>e_75_center&#45;&gt;6pgc_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.75" d="M1092,-892.24C1095.99,-885.77 1104.82,-872.41 1114.75,-863.38 1177.92,-805.99 1267.9,-758.18 1311.36,-736.79"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.75" points="1313.21,-740.5 1320.39,-732.39 1309.58,-733.03 1313.21,-740.5"/>
+</g>
+<!-- e_77_center&#45;&gt;h_c -->
+<g id="edge279" class="edge">
+<title>e_77_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.25" d="M741.49,-1308.39C765.79,-1295.95 899.47,-1227.52 955.91,-1198.63"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.25" points="957.59,-1201.7 964.89,-1194.03 954.4,-1195.47 957.59,-1201.7"/>
+</g>
+<!-- e_77_center&#45;&gt;pi_c -->
+<g id="edge278" class="edge">
+<title>e_77_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.25" d="M738.49,-1306.67C743.52,-1284.48 770.67,-1166.26 799.79,-1071.78 806.37,-1050.45 814.92,-1026.67 821.53,-1009"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.25" points="824.9,-1009.96 825.16,-999.37 818.35,-1007.49 824.9,-1009.96"/>
+</g>
+<!-- e_78_center&#45;&gt;h_c -->
+<g id="edge284" class="edge">
+<title>e_78_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.84" d="M1003.91,-923.44C1001.71,-948.7 989.01,-1094.58 983.56,-1157.21"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="0.84" points="980.04,-1157.28 982.66,-1167.54 987.01,-1157.88 980.04,-1157.28"/>
+</g>
+<!-- e_78_center&#45;&gt;pi_c -->
+<g id="edge283" class="edge">
+<title>e_78_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.84" d="M1000.64,-920.98C982.59,-927.55 901.16,-957.15 858.3,-972.73"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="0.84" points="856.99,-969.48 848.79,-976.19 859.38,-976.06 856.99,-969.48"/>
+</g>
+<!-- e_78_center&#45;&gt;oaa_c -->
+<g id="edge285" class="edge">
+<title>e_78_center&#45;&gt;oaa_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.84" d="M1001.46,-923.29C995.54,-930.97 981.3,-949.46 969.68,-964.54"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="0.84" points="966.9,-962.41 963.57,-972.47 972.45,-966.68 966.9,-962.41"/>
+</g>
+<!-- e_79_center&#45;&gt;adp_c -->
+<g id="edge289" class="edge">
+<title>e_79_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M976.66,-796.4C957.33,-811.2 867.53,-879.9 824.94,-912.48"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="822.66,-909.82 816.85,-918.67 826.92,-915.37 822.66,-909.82"/>
+</g>
+<!-- e_79_center&#45;&gt;co2_c -->
+<g id="edge288" class="edge">
+<title>e_79_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M983.88,-794.46C1009.27,-800.95 1165.93,-841.01 1230.04,-857.41"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1229.3,-860.83 1239.85,-859.92 1231.03,-854.05 1229.3,-860.83"/>
+</g>
+<!-- e_79_center&#45;&gt;pep_c -->
+<g id="edge290" class="edge">
+<title>e_79_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M983.4,-789.88C994.12,-776.83 1030.85,-732.12 1053.28,-704.81"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1056.09,-706.9 1059.74,-696.95 1050.69,-702.45 1056.09,-706.9"/>
+</g>
+<!-- e_80_center&#45;&gt;h_c -->
+<g id="edge297" class="edge">
+<title>e_80_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.78" d="M915.34,-862.91C916.94,-878 923.58,-938.03 932.87,-986.74 944.69,-1048.66 963.26,-1120.29 973.56,-1158.46"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.78" points="970.24,-1159.57 976.23,-1168.31 976.99,-1157.74 970.24,-1159.57"/>
+</g>
+<!-- e_80_center&#45;&gt;amp_c -->
+<g id="edge295" class="edge">
+<title>e_80_center&#45;&gt;amp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.78" d="M911.4,-855.45C893.92,-836.4 815.37,-751.21 748.03,-684.35 738.78,-675.18 728.31,-665.26 719.37,-656.93"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.78" points="721.68,-654.3 711.97,-650.07 716.93,-659.44 721.68,-654.3"/>
+</g>
+<!-- e_80_center&#45;&gt;pi_c -->
+<g id="edge294" class="edge">
+<title>e_80_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.78" d="M911.78,-863.1C904.58,-871.64 886.69,-893.28 873.44,-912.64 863.46,-927.2 853.28,-944.19 845.47,-957.76"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.78" points="842.38,-956.11 840.47,-966.53 848.46,-959.57 842.38,-956.11"/>
+</g>
+<!-- e_80_center&#45;&gt;pep_c -->
+<g id="edge296" class="edge">
+<title>e_80_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.78" d="M917.81,-855.64C926.14,-844.84 951.32,-812.49 973.68,-786.86 999.79,-756.93 1031.51,-723.68 1051.54,-703.04"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.78" points="1054.14,-705.38 1058.61,-695.78 1049.13,-700.5 1054.14,-705.38"/>
+</g>
+<!-- e_81_center&#45;&gt;coa_c -->
+<g id="edge300" class="edge">
+<title>e_81_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M763.52,-1125.01C776.22,-1124.74 819.64,-1123.68 855.41,-1121.31 901.36,-1118.28 954.59,-1112.98 986.49,-1109.62"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="987.26,-1113.06 996.83,-1108.52 986.52,-1106.09 987.26,-1113.06"/>
+</g>
+<!-- e_81_center&#45;&gt;actp_c -->
+<g id="edge301" class="edge">
+<title>e_81_center&#45;&gt;actp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M755.98,-1125.54C740.59,-1127.34 682.5,-1134.03 634.59,-1138.62 589.35,-1142.95 536.74,-1147.17 505.19,-1149.62"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="504.66,-1146.15 494.96,-1150.41 505.2,-1153.13 504.66,-1146.15"/>
+</g>
+<!-- e_82_center&#45;&gt;atp_c -->
+<g id="edge306" class="edge">
+<title>e_82_center&#45;&gt;atp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M974.79,-893.69C953.39,-892.59 844.94,-887.02 792.69,-884.33"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="792.62,-880.82 782.45,-883.8 792.26,-887.81 792.62,-880.82"/>
+</g>
+<!-- e_82_center&#45;&gt;pyr_c -->
+<g id="edge305" class="edge">
+<title>e_82_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M982.18,-894.6C996.69,-897.33 1051.46,-906.77 1096.45,-902.71 1110.88,-901.41 1114.32,-899.78 1128.52,-896.88 1145.83,-893.35 1165.17,-888.98 1180.42,-885.43"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1181.31,-888.82 1190.24,-883.13 1179.71,-882 1181.31,-888.82"/>
+</g>
+<!-- e_83_center&#45;&gt;h_c -->
+<g id="edge310" class="edge">
+<title>e_83_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1284,-1201.37C1255.62,-1199.91 1079.18,-1190.81 1009.41,-1187.21"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1009.34,-1183.71 999.17,-1186.69 1008.98,-1190.7 1009.34,-1183.71"/>
+</g>
+<!-- e_83_center&#45;&gt;pyr_c -->
+<g id="edge309" class="edge">
+<title>e_83_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1286.98,-1197.95C1279.88,-1169.31 1232.59,-978.7 1214.69,-906.53"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1218.08,-905.64 1212.27,-896.78 1211.28,-907.33 1218.08,-905.64"/>
+</g>
+<!-- xu5p__D_c&#45;&gt;e_92_center -->
+<g id="edge341" class="edge">
+<title>xu5p__D_c&#45;&gt;e_92_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.91" d="M1231.35,-154.43C1201.24,-173 1136.16,-213.12 1120.36,-222.86"/>
+</g>
+<!-- xu5p__D_c&#45;&gt;e_93_center -->
+<g id="edge346" class="edge">
+<title>xu5p__D_c&#45;&gt;e_93_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.85" d="M1235.6,-159.34C1207.29,-195.92 1133.82,-290.82 1118.64,-310.43"/>
+</g>
+<!-- e_86_center&#45;&gt;h_c -->
+<g id="edge315" class="edge">
+<title>e_86_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M905.7,-1516.98C912.5,-1487.11 957.91,-1287.52 974.78,-1213.4"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="978.25,-1213.94 977.05,-1203.41 971.42,-1212.38 978.25,-1213.94"/>
+</g>
+<!-- e_86_center&#45;&gt;succ_c -->
+<g id="edge316" class="edge">
+<title>e_86_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M901.06,-1520.18C880.69,-1517.2 783.27,-1502.94 734.44,-1495.79"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="734.92,-1492.32 724.52,-1494.34 733.91,-1499.25 734.92,-1492.32"/>
+</g>
+<!-- e_87_center&#45;&gt;h_c -->
+<g id="edge320" class="edge">
+<title>e_87_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M878.48,-1504.6C887.71,-1475.91 949.27,-1284.6 972.35,-1212.86"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="975.73,-1213.77 975.46,-1203.18 969.07,-1211.62 975.73,-1213.77"/>
+</g>
+<!-- e_87_center&#45;&gt;succ_e -->
+<g id="edge319" class="edge">
+<title>e_87_center&#45;&gt;succ_e</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M876.91,-1511.73C873.97,-1537.04 855.88,-1692.63 848.35,-1757.35"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="844.84,-1757.29 847.16,-1767.63 851.79,-1758.1 844.84,-1757.29"/>
+</g>
+<!-- e_88_center&#45;&gt;q8h2_c -->
+<g id="edge323" class="edge">
+<title>e_88_center&#45;&gt;q8h2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M668.82,-1677.69C682.18,-1667.13 727.9,-1631.06 766.01,-1601.73 773.57,-1595.91 781.87,-1589.6 789.33,-1583.96"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="791.72,-1586.54 797.6,-1577.72 787.51,-1580.95 791.72,-1586.54"/>
+</g>
+<!-- e_88_center&#45;&gt;fum_c -->
+<g id="edge324" class="edge">
+<title>e_88_center&#45;&gt;fum_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M668.55,-1678.71C681.39,-1671.43 726.12,-1646.1 754.78,-1629.86"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="756.83,-1632.72 763.81,-1624.75 753.38,-1626.63 756.83,-1632.72"/>
+</g>
+<!-- e_89_center&#45;&gt;adp_c -->
+<g id="edge329" class="edge">
+<title>e_89_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M807.9,-1162.35C806.27,-1150.91 801.38,-1115.07 799.79,-1085.18 797.43,-1040.81 799.19,-989.23 800.74,-958.05"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="804.24,-958.09 801.28,-947.92 797.25,-957.72 804.24,-958.09"/>
+</g>
+<!-- e_89_center&#45;&gt;succoa_c -->
+<g id="edge330" class="edge">
+<title>e_89_center&#45;&gt;succoa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M811.96,-1167.04C821.21,-1169.7 846.93,-1177.31 867.61,-1185.61 914.87,-1204.56 968.07,-1230.97 998.58,-1246.64"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="997.16,-1249.84 1007.65,-1251.32 1000.37,-1243.62 997.16,-1249.84"/>
+</g>
+<!-- e_89_center&#45;&gt;pi_c -->
+<g id="edge328" class="edge">
+<title>e_89_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M808.88,-1162.54C811.23,-1143.99 822.34,-1056.41 828.16,-1010.55"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="831.67,-1010.74 829.45,-1000.38 824.72,-1009.86 831.67,-1010.74"/>
+</g>
+<!-- s7p_c -->
+<g id="node152" class="node">
+<title>s7p_c</title>
+<ellipse fill="none" stroke="black" cx="1091.98" cy="-39.09" rx="18" ry="18"/>
+<text text-anchor="middle" x="1091.98" y="-35.39" font-family="Times,serif" font-size="14.00">s7p_c</text>
+</g>
+<!-- s7p_c&#45;&gt;e_90_center -->
+<g id="edge331" class="edge">
+<title>s7p_c&#45;&gt;e_90_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.91" d="M1088.56,-57.16C1078.9,-108.28 1051.78,-251.76 1047.19,-276.04"/>
+</g>
+<!-- e_90_center&#45;&gt;f6p_c -->
+<g id="edge334" class="edge">
+<title>e_90_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.91" d="M1046.11,-283.2C1043.92,-302.56 1033.87,-395.18 1033.61,-471.22 1033.55,-486.7 1034.52,-503.95 1035.58,-518"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.91" points="1032.1,-518.35 1036.39,-528.03 1039.07,-517.79 1032.1,-518.35"/>
+</g>
+<!-- e_90_center&#45;&gt;e4p_c -->
+<g id="edge333" class="edge">
+<title>e_90_center&#45;&gt;e4p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.91" d="M1046.66,-283.22C1047.34,-302.72 1050.56,-395.32 1052.22,-442.92"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.91" points="1048.73,-443.29 1052.57,-453.16 1055.72,-443.05 1048.73,-443.29"/>
+</g>
+<!-- e_91_center&#45;&gt;nad_c -->
+<g id="edge338" class="edge">
+<title>e_91_center&#45;&gt;nad_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1116.48,-1137.76C1116.88,-1134.01 1117.53,-1127.92 1118.22,-1121.42"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1121.74,-1121.47 1119.32,-1111.16 1114.78,-1120.73 1121.74,-1121.47"/>
+</g>
+<!-- e_91_center&#45;&gt;h_c -->
+<g id="edge339" class="edge">
+<title>e_91_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1112.46,-1142.74C1097.87,-1147.52 1042.41,-1165.67 1008.38,-1176.81"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1006.99,-1173.58 998.58,-1180.02 1009.17,-1180.23 1006.99,-1173.58"/>
+</g>
+<!-- e_91_center&#45;&gt;nadph_c -->
+<g id="edge340" class="edge">
+<title>e_91_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1114.24,-1137.64C1110.61,-1129.52 1102.72,-1110.19 1101.65,-1092.99 1098.43,-1041.56 1112.09,-982.46 1121.57,-948.73"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1125.05,-949.29 1124.47,-938.71 1118.33,-947.34 1125.05,-949.29"/>
+</g>
+<!-- e_92_center&#45;&gt;g3p_c -->
+<g id="edge344" class="edge">
+<title>e_92_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.91" d="M1115.1,-228.71C1104.04,-251.98 1043.5,-379.3 1017.33,-434.34"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.91" points="1014.14,-432.9 1013.01,-443.43 1020.46,-435.91 1014.14,-432.9"/>
+</g>
+<!-- e_92_center&#45;&gt;s7p_c -->
+<g id="edge343" class="edge">
+<title>e_92_center&#45;&gt;s7p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.91" d="M1116.38,-221.48C1113.85,-202.61 1101.89,-113.21 1095.71,-66.96"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.91" points="1099.17,-66.44 1094.37,-56.99 1092.23,-67.37 1099.17,-66.44"/>
+</g>
+<!-- e_93_center&#45;&gt;f6p_c -->
+<g id="edge348" class="edge">
+<title>e_93_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.85" d="M1115.19,-317.88C1111.76,-336.83 1095.47,-421.42 1067,-485.23 1061.78,-496.94 1055.74,-509.78 1050.55,-520.65"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.85" points="1047.24,-519.46 1046.06,-529.99 1053.55,-522.49 1047.24,-519.46"/>
+</g>
+<!-- e_93_center&#45;&gt;g3p_c -->
+<g id="edge347" class="edge">
+<title>e_93_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.85" d="M1113.14,-317.61C1100.81,-333.85 1049.81,-401.03 1022.59,-436.9"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.85" points="1019.47,-435.21 1016.21,-445.29 1025.05,-439.44 1019.47,-435.21"/>
+</g>
+</g>
+</svg>
\ No newline at end of file
diff --git a/main/_images/c0a2bcef604ae3b0817afcfb97fcec57469cdf598b7734ff90c891e19dea50fa.svg b/main/_images/c0a2bcef604ae3b0817afcfb97fcec57469cdf598b7734ff90c891e19dea50fa.svg
new file mode 100644
index 00000000..c14290cb
--- /dev/null
+++ b/main/_images/c0a2bcef604ae3b0817afcfb97fcec57469cdf598b7734ff90c891e19dea50fa.svg
@@ -0,0 +1,2802 @@
+<?xml version="1.0" encoding="UTF-8" standalone="no"?>
+<!DOCTYPE svg PUBLIC "-//W3C//DTD SVG 1.1//EN"
+ "http://www.w3.org/Graphics/SVG/1.1/DTD/svg11.dtd">
+<!-- Generated by graphviz version 2.43.0 (0)
+ -->
+<!-- Title: %3 Pages: 1 -->
+<svg width="2169pt" height="2236pt"
+ viewBox="0.00 0.00 2169.00 2236.00" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
+<g id="graph0" class="graph" transform="scale(1 1) rotate(0) translate(4 2232)">
+<title>%3</title>
+<polygon fill="white" stroke="transparent" points="-4,4 -4,-2232 2165,-2232 2165,4 -4,4"/>
+<!-- coa_c -->
+<g id="node1" class="node">
+<title>coa_c</title>
+<ellipse fill="none" stroke="black" cx="1015" cy="-1106.52" rx="18" ry="18"/>
+<text text-anchor="middle" x="1015" y="-1102.82" font-family="Times,serif" font-size="14.00">coa_c</text>
+</g>
+<!-- e_0_center -->
+<g id="node7" class="node">
+<title>e_0_center</title>
+<polygon fill="none" stroke="black" points="1228.52,-1209.9 1221.52,-1209.9 1221.52,-1202.9 1228.52,-1202.9 1228.52,-1209.9"/>
+</g>
+<!-- coa_c&#45;&gt;e_0_center -->
+<g id="edge1" class="edge">
+<title>coa_c&#45;&gt;e_0_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1031.48,-1114.35C1076.35,-1135.69 1198.85,-1193.95 1221.42,-1204.68"/>
+</g>
+<!-- e_7_center -->
+<g id="node28" class="node">
+<title>e_7_center</title>
+<polygon fill="none" stroke="black" points="1205.03,-1100.88 1198.03,-1100.88 1198.03,-1093.88 1205.03,-1093.88 1205.03,-1100.88"/>
+</g>
+<!-- coa_c&#45;&gt;e_7_center -->
+<g id="edge25" class="edge">
+<title>coa_c&#45;&gt;e_7_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1033.03,-1108.93C1054.14,-1111.43 1090.17,-1114.74 1121.11,-1112.72 1151.18,-1110.76 1186.6,-1101.52 1197.89,-1098.41"/>
+</g>
+<!-- e_70_center -->
+<g id="node135" class="node">
+<title>e_70_center</title>
+<polygon fill="none" stroke="black" points="1201.34,-1000.02 1194.34,-1000.02 1194.34,-993.02 1201.34,-993.02 1201.34,-1000.02"/>
+</g>
+<!-- coa_c&#45;&gt;e_70_center -->
+<g id="edge251" class="edge">
+<title>coa_c&#45;&gt;e_70_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1032.12,-1100.68C1042.8,-1096.99 1056.79,-1092.05 1069.08,-1087.39 1075.32,-1085.02 1077.17,-1085.01 1082.98,-1081.74 1130.17,-1055.22 1180.28,-1012.06 1194.12,-999.84"/>
+</g>
+<!-- e_72_center -->
+<g id="node137" class="node">
+<title>e_72_center</title>
+<polygon fill="none" stroke="black" points="1284.92,-1123.9 1277.92,-1123.9 1277.92,-1116.9 1284.92,-1116.9 1284.92,-1123.9"/>
+</g>
+<!-- coa_c&#45;&gt;e_72_center -->
+<g id="edge262" class="edge">
+<title>coa_c&#45;&gt;e_72_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1033.02,-1107.63C1054.13,-1108.92 1090.15,-1111.07 1121.11,-1112.72 1183.44,-1116.03 1259.43,-1119.43 1277.46,-1120.23"/>
+</g>
+<!-- e_89_center -->
+<g id="node151" class="node">
+<title>e_89_center</title>
+<polygon fill="none" stroke="black" points="811.94,-1169.54 804.94,-1169.54 804.94,-1162.54 811.94,-1162.54 811.94,-1169.54"/>
+</g>
+<!-- coa_c&#45;&gt;e_89_center -->
+<g id="edge325" class="edge">
+<title>coa_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M997.38,-1111.59C952.31,-1124.58 834.73,-1158.46 812.2,-1164.96"/>
+</g>
+<!-- acald_c -->
+<g id="node2" class="node">
+<title>acald_c</title>
+<ellipse fill="none" stroke="black" cx="1557.48" cy="-1324.36" rx="18" ry="18"/>
+<text text-anchor="middle" x="1557.48" y="-1320.66" font-family="Times,serif" font-size="14.00">acald_c</text>
+</g>
+<!-- acald_c&#45;&gt;e_0_center -->
+<g id="edge2" class="edge">
+<title>acald_c&#45;&gt;e_0_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1540.07,-1318.18C1476.47,-1295.61 1258.82,-1218.39 1228.53,-1207.64"/>
+</g>
+<!-- nad_c -->
+<g id="node3" class="node">
+<title>nad_c</title>
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+<!-- nad_c&#45;&gt;e_0_center -->
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+<!-- nad_c&#45;&gt;e_7_center -->
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+<!-- e_9_center -->
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+<!-- nad_c&#45;&gt;e_9_center -->
+<g id="edge35" class="edge">
+<title>nad_c&#45;&gt;e_9_center</title>
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+<!-- e_12_center -->
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+<!-- nad_c&#45;&gt;e_12_center -->
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+<!-- e_48_center -->
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+<!-- nad_c&#45;&gt;e_48_center -->
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+<!-- e_60_center -->
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+<!-- nad_c&#45;&gt;e_60_center -->
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+<!-- e_63_center -->
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+<!-- nad_c&#45;&gt;e_63_center -->
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+<!-- e_64_center -->
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+<!-- e_67_center -->
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+<!-- nad_c&#45;&gt;e_67_center -->
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+<!-- nad_c&#45;&gt;e_70_center -->
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+<!-- h_c -->
+<g id="node4" class="node">
+<title>h_c</title>
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+<!-- e_15_center -->
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+<!-- h_c&#45;&gt;e_15_center -->
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+<!-- e_54_center -->
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+<!-- h_c&#45;&gt;e_54_center -->
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+<!-- e_66_center -->
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+<!-- h_c&#45;&gt;e_66_center -->
+<g id="edge241" class="edge">
+<title>h_c&#45;&gt;e_66_center</title>
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+<!-- e_82_center -->
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+<!-- h_c&#45;&gt;e_82_center -->
+<g id="edge304" class="edge">
+<title>h_c&#45;&gt;e_82_center</title>
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+</g>
+<!-- nadh_c -->
+<g id="node5" class="node">
+<title>nadh_c</title>
+<ellipse fill="none" stroke="black" cx="1165.38" cy="-1066.7" rx="18" ry="18"/>
+<text text-anchor="middle" x="1165.38" y="-1063" font-family="Times,serif" font-size="14.00">nadh_c</text>
+</g>
+<!-- nadh_c&#45;&gt;e_66_center -->
+<g id="edge240" class="edge">
+<title>nadh_c&#45;&gt;e_66_center</title>
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+<!-- e_91_center -->
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+<!-- nadh_c&#45;&gt;e_91_center -->
+<g id="edge337" class="edge">
+<title>nadh_c&#45;&gt;e_91_center</title>
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+<!-- accoa_c -->
+<g id="node6" class="node">
+<title>accoa_c</title>
+<ellipse fill="none" stroke="black" cx="1022.87" cy="-1062.38" rx="18" ry="18"/>
+<text text-anchor="middle" x="1022.87" y="-1058.68" font-family="Times,serif" font-size="14.00">accoa_c</text>
+</g>
+<!-- accoa_c&#45;&gt;e_12_center -->
+<g id="edge55" class="edge">
+<title>accoa_c&#45;&gt;e_12_center</title>
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+<!-- e_14_center -->
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+<!-- accoa_c&#45;&gt;e_14_center -->
+<g id="edge76" class="edge">
+<title>accoa_c&#45;&gt;e_14_center</title>
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+<!-- e_61_center -->
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+<!-- accoa_c&#45;&gt;e_61_center -->
+<g id="edge216" class="edge">
+<title>accoa_c&#45;&gt;e_61_center</title>
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+<!-- e_81_center -->
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+<!-- accoa_c&#45;&gt;e_81_center -->
+<g id="edge299" class="edge">
+<title>accoa_c&#45;&gt;e_81_center</title>
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+<!-- e_0_center&#45;&gt;h_c -->
+<g id="edge4" class="edge">
+<title>e_0_center&#45;&gt;h_c</title>
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+<!-- e_0_center&#45;&gt;nadh_c -->
+<g id="edge5" class="edge">
+<title>e_0_center&#45;&gt;nadh_c</title>
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+<!-- e_0_center&#45;&gt;accoa_c -->
+<g id="edge6" class="edge">
+<title>e_0_center&#45;&gt;accoa_c</title>
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+<!-- acald_e -->
+<g id="node8" class="node">
+<title>acald_e</title>
+<ellipse fill="none" stroke="black" cx="1918.06" cy="-1433.48" rx="18" ry="18"/>
+<text text-anchor="middle" x="1918.06" y="-1429.78" font-family="Times,serif" font-size="14.00">acald_e</text>
+</g>
+<!-- acald_e&#45;&gt;acald_c -->
+<g id="edge7" class="edge">
+<title>acald_e&#45;&gt;acald_c</title>
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+<!-- e_20_target -->
+<g id="node64" class="node">
+<title>e_20_target</title>
+<ellipse fill="black" stroke="black" cx="2159.66" cy="-1507.22" rx="1.8" ry="1.8"/>
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+<!-- acald_e&#45;&gt;e_20_target -->
+<g id="edge99" class="edge">
+<title>acald_e&#45;&gt;e_20_target</title>
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+<!-- ac_c -->
+<g id="node9" class="node">
+<title>ac_c</title>
+<ellipse fill="none" stroke="black" cx="464.62" cy="-1287.85" rx="18" ry="18"/>
+<text text-anchor="middle" x="464.62" y="-1284.15" font-family="Times,serif" font-size="14.00">ac_c</text>
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+<!-- e_2_center -->
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+<polygon fill="none" stroke="black" points="567.08,-1052.48 560.08,-1052.48 560.08,-1045.48 567.08,-1045.48 567.08,-1052.48"/>
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+<!-- ac_c&#45;&gt;e_2_center -->
+<g id="edge8" class="edge">
+<title>ac_c&#45;&gt;e_2_center</title>
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+</g>
+<!-- atp_c -->
+<g id="node10" class="node">
+<title>atp_c</title>
+<ellipse fill="none" stroke="black" cx="764.47" cy="-882.88" rx="18" ry="18"/>
+<text text-anchor="middle" x="764.47" y="-879.18" font-family="Times,serif" font-size="14.00">atp_c</text>
+</g>
+<!-- atp_c&#45;&gt;e_2_center -->
+<g id="edge9" class="edge">
+<title>atp_c&#45;&gt;e_2_center</title>
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+<!-- e_6_center -->
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+<!-- atp_c&#45;&gt;e_6_center -->
+<g id="edge23" class="edge">
+<title>atp_c&#45;&gt;e_6_center</title>
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+<!-- e_10_center -->
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+<!-- atp_c&#45;&gt;e_10_center -->
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+<!-- atp_c&#45;&gt;e_12_center -->
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+<!-- e_50_center -->
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+<!-- atp_c&#45;&gt;e_50_center -->
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+<!-- e_51_center -->
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+<!-- atp_c&#45;&gt;e_51_center -->
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+<!-- e_71_center -->
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+<!-- atp_c&#45;&gt;e_71_center -->
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+<!-- e_74_center -->
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+<!-- atp_c&#45;&gt;e_74_center -->
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+<title>atp_c&#45;&gt;e_74_center</title>
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+<!-- e_79_center -->
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+<!-- atp_c&#45;&gt;e_79_center -->
+<g id="edge286" class="edge">
+<title>atp_c&#45;&gt;e_79_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M781.41,-875.87C827.54,-856.79 953.47,-804.69 976.68,-795.09"/>
+</g>
+<!-- e_80_center -->
+<g id="node143" class="node">
+<title>e_80_center</title>
+<polygon fill="none" stroke="black" points="918.47,-862.84 911.47,-862.84 911.47,-855.84 918.47,-855.84 918.47,-862.84"/>
+</g>
+<!-- atp_c&#45;&gt;e_80_center -->
+<g id="edge293" class="edge">
+<title>atp_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M782.33,-880.09C817.52,-874.58 893.95,-862.63 911.38,-859.9"/>
+</g>
+<!-- atp_c&#45;&gt;e_89_center -->
+<g id="edge326" class="edge">
+<title>atp_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M767.29,-901.02C776.23,-958.64 803.66,-1135.25 807.89,-1162.5"/>
+</g>
+<!-- adp_c -->
+<g id="node11" class="node">
+<title>adp_c</title>
+<ellipse fill="none" stroke="black" cx="802.41" cy="-929.72" rx="18" ry="18"/>
+<text text-anchor="middle" x="802.41" y="-926.02" font-family="Times,serif" font-size="14.00">adp_c</text>
+</g>
+<!-- e_11_center -->
+<g id="node35" class="node">
+<title>e_11_center</title>
+<polygon fill="none" stroke="black" points="852.21,-1118.11 845.21,-1118.11 845.21,-1111.11 852.21,-1111.11 852.21,-1118.11"/>
+</g>
+<!-- adp_c&#45;&gt;e_11_center -->
+<g id="edge46" class="edge">
+<title>adp_c&#45;&gt;e_11_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M805.35,-947.83C807.11,-958.02 809.51,-970.95 812.14,-982.36 824,-1033.9 842.79,-1095.5 847.58,-1110.96"/>
+</g>
+<!-- adp_c&#45;&gt;e_82_center -->
+<g id="edge302" class="edge">
+<title>adp_c&#45;&gt;e_82_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M819.86,-925.22C834.2,-921.59 855.06,-916.48 873.44,-912.64 912.97,-904.36 961.36,-896.58 974.86,-894.46"/>
+</g>
+<!-- actp_c -->
+<g id="node12" class="node">
+<title>actp_c</title>
+<ellipse fill="none" stroke="black" cx="476.98" cy="-1151.77" rx="18" ry="18"/>
+<text text-anchor="middle" x="476.98" y="-1148.07" font-family="Times,serif" font-size="14.00">actp_c</text>
+</g>
+<!-- e_2_center&#45;&gt;adp_c -->
+<g id="edge10" class="edge">
+<title>e_2_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M567.11,-1047.91C586.64,-1041.9 682.9,-1011.23 753.1,-969.39 762.87,-963.56 772.8,-955.97 781.16,-948.98"/>
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+</g>
+<!-- e_2_center&#45;&gt;actp_c -->
+<g id="edge11" class="edge">
+<title>e_2_center&#45;&gt;actp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M560.29,-1052.88C549.79,-1065.34 516.57,-1104.78 495.39,-1129.92"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="492.48,-1127.94 488.71,-1137.84 497.83,-1132.45 492.48,-1127.94"/>
+</g>
+<!-- cit_c -->
+<g id="node14" class="node">
+<title>cit_c</title>
+<ellipse fill="none" stroke="black" cx="499.3" cy="-1028.97" rx="18" ry="18"/>
+<text text-anchor="middle" x="499.3" y="-1025.27" font-family="Times,serif" font-size="14.00">cit_c</text>
+</g>
+<!-- e_3_center -->
+<g id="node17" class="node">
+<title>e_3_center</title>
+<polygon fill="none" stroke="black" points="417.08,-914.83 410.08,-914.83 410.08,-907.83 417.08,-907.83 417.08,-914.83"/>
+</g>
+<!-- cit_c&#45;&gt;e_3_center -->
+<g id="edge12" class="edge">
+<title>cit_c&#45;&gt;e_3_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M488.44,-1014.07C468.44,-986.62 426.83,-929.51 416.13,-914.83"/>
+</g>
+<!-- h2o_c -->
+<g id="node15" class="node">
+<title>h2o_c</title>
+<ellipse fill="none" stroke="black" cx="739.36" cy="-955.4" rx="18" ry="18"/>
+<text text-anchor="middle" x="739.36" y="-951.7" font-family="Times,serif" font-size="14.00">h2o_c</text>
+</g>
+<!-- e_4_center -->
+<g id="node19" class="node">
+<title>e_4_center</title>
+<polygon fill="none" stroke="black" points="439.95,-982.98 432.95,-982.98 432.95,-975.98 439.95,-975.98 439.95,-982.98"/>
+</g>
+<!-- h2o_c&#45;&gt;e_4_center -->
+<g id="edge15" class="edge">
+<title>h2o_c&#45;&gt;e_4_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M721.32,-956.84C661.21,-961.62 469.83,-976.83 440.3,-979.18"/>
+</g>
+<!-- h2o_c&#45;&gt;e_10_center -->
+<g id="edge40" class="edge">
+<title>h2o_c&#45;&gt;e_10_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M739.71,-973.62C740.07,-981.96 740.79,-991.95 742.2,-1000.85 745.52,-1021.64 753.03,-1045.83 755.94,-1054.8"/>
+</g>
+<!-- h2o_c&#45;&gt;e_12_center -->
+<g id="edge58" class="edge">
+<title>h2o_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M752.79,-942.83C762.27,-934.41 775.56,-923.5 788.6,-915.81 842.97,-883.71 864.48,-892.8 921.67,-866.04 946.55,-854.4 974.52,-836.74 984.49,-830.29"/>
+</g>
+<!-- h2o_c&#45;&gt;e_14_center -->
+<g id="edge75" class="edge">
+<title>h2o_c&#45;&gt;e_14_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M754.27,-965.8C761.48,-971.42 769.83,-978.88 775.68,-987.03 796.79,-1016.42 804.21,-1061.32 806.02,-1074.63"/>
+</g>
+<!-- e_40_center -->
+<g id="node99" class="node">
+<title>e_40_center</title>
+<polygon fill="none" stroke="black" points="836.01,-709.7 829.01,-709.7 829.01,-702.7 836.01,-702.7 836.01,-709.7"/>
+</g>
+<!-- h2o_c&#45;&gt;e_40_center -->
+<g id="edge121" class="edge">
+<title>h2o_c&#45;&gt;e_40_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M750.42,-940.47C758.69,-928.91 769.96,-912.31 778.26,-896.81 815.47,-827.36 829.52,-729.64 832.06,-709.8"/>
+</g>
+<!-- e_45_center -->
+<g id="node107" class="node">
+<title>e_45_center</title>
+<polygon fill="none" stroke="black" points="836.29,-1310.83 829.29,-1310.83 829.29,-1303.83 836.29,-1303.83 836.29,-1310.83"/>
+</g>
+<!-- h2o_c&#45;&gt;e_45_center -->
+<g id="edge138" class="edge">
+<title>h2o_c&#45;&gt;e_45_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M739.14,-973.73C739.39,-982.1 740.18,-992.07 742.2,-1000.85 743.7,-1007.34 745.34,-1008.57 747.93,-1014.71 754.87,-1031.2 757.95,-1034.79 763.83,-1051.68 798.88,-1152.41 827.04,-1280.53 832.01,-1303.67"/>
+</g>
+<!-- h2o_c&#45;&gt;e_51_center -->
+<g id="edge167" class="edge">
+<title>h2o_c&#45;&gt;e_51_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M722.21,-961.04C698.41,-968.87 656.89,-982.53 644.49,-986.6"/>
+</g>
+<!-- e_52_center -->
+<g id="node117" class="node">
+<title>e_52_center</title>
+<polygon fill="none" stroke="black" points="883.64,-922.84 876.64,-922.84 876.64,-915.84 883.64,-915.84 883.64,-922.84"/>
+</g>
+<!-- h2o_c&#45;&gt;e_52_center -->
+<g id="edge174" class="edge">
+<title>h2o_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M757.49,-954.95C770.19,-954.32 787.48,-952.83 802.34,-949.32 831.92,-942.32 865.32,-926.63 876.37,-921.22"/>
+</g>
+<!-- e_53_center -->
+<g id="node118" class="node">
+<title>e_53_center</title>
+<polygon fill="none" stroke="black" points="590.47,-849.61 583.47,-849.61 583.47,-842.61 590.47,-842.61 590.47,-849.61"/>
+</g>
+<!-- h2o_c&#45;&gt;e_53_center -->
+<g id="edge181" class="edge">
+<title>h2o_c&#45;&gt;e_53_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M724.97,-944.59C721.42,-941.95 717.62,-939.14 714.08,-936.57 665.48,-901.17 605.58,-859.14 590.53,-848.6"/>
+</g>
+<!-- h2o_c&#45;&gt;e_61_center -->
+<g id="edge214" class="edge">
+<title>h2o_c&#45;&gt;e_61_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M754.18,-965.86C761.37,-971.5 769.73,-978.96 775.68,-987.03 828.36,-1058.46 855.18,-1167.24 860.09,-1188.59"/>
+</g>
+<!-- e_75_center -->
+<g id="node139" class="node">
+<title>e_75_center</title>
+<polygon fill="none" stroke="black" points="1093.25,-899.51 1086.25,-899.51 1086.25,-892.51 1093.25,-892.51 1093.25,-899.51"/>
+</g>
+<!-- h2o_c&#45;&gt;e_75_center -->
+<g id="edge271" class="edge">
+<title>h2o_c&#45;&gt;e_75_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M757.33,-954.09C769.96,-953.06 787.22,-951.45 802.34,-949.32 889.72,-936.98 910.77,-929.03 997.54,-912.97 1032.11,-906.58 1073.99,-898.9 1086.23,-896.66"/>
+</g>
+<!-- e_78_center -->
+<g id="node141" class="node">
+<title>e_78_center</title>
+<polygon fill="none" stroke="black" points="1007.74,-923.17 1000.74,-923.17 1000.74,-916.17 1007.74,-916.17 1007.74,-923.17"/>
+</g>
+<!-- h2o_c&#45;&gt;e_78_center -->
+<g id="edge280" class="edge">
+<title>h2o_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M757.31,-953.91C769.92,-952.8 787.18,-951.16 802.34,-949.32 882.88,-939.52 980.89,-923.53 1000.67,-920.27"/>
+</g>
+<!-- h2o_c&#45;&gt;e_80_center -->
+<g id="edge291" class="edge">
+<title>h2o_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M752.87,-942.95C762.39,-934.59 775.68,-923.7 788.6,-915.81 834.11,-887.98 895.72,-865.95 911.28,-860.59"/>
+</g>
+<!-- acon_C_c -->
+<g id="node16" class="node">
+<title>acon_C_c</title>
+<ellipse fill="none" stroke="black" cx="210.14" cy="-912.3" rx="18" ry="18"/>
+<text text-anchor="middle" x="210.14" y="-908.6" font-family="Times,serif" font-size="14.00">acon_C_c</text>
+</g>
+<!-- acon_C_c&#45;&gt;e_4_center -->
+<g id="edge16" class="edge">
+<title>acon_C_c&#45;&gt;e_4_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M225.9,-921.16C235.46,-926.41 247.96,-933.07 259.33,-938.43 324.42,-969.14 414.07,-977.71 432.9,-979.22"/>
+</g>
+<!-- e_3_center&#45;&gt;h2o_c -->
+<g id="edge13" class="edge">
+<title>e_3_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M417.24,-911.82C446.1,-915.73 637.82,-941.67 711.03,-951.57"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="710.95,-955.09 721.33,-952.96 711.89,-948.15 710.95,-955.09"/>
+</g>
+<!-- e_3_center&#45;&gt;acon_C_c -->
+<g id="edge14" class="edge">
+<title>e_3_center&#45;&gt;acon_C_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M409.68,-910.92C393.15,-909.25 327.34,-903.08 273.22,-904.98 261.74,-905.39 249.14,-906.68 238.25,-908.06"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="237.47,-904.64 228.03,-909.45 238.41,-911.57 237.47,-904.64"/>
+</g>
+<!-- icit_c -->
+<g id="node18" class="node">
+<title>icit_c</title>
+<ellipse fill="none" stroke="black" cx="634.63" cy="-1119.02" rx="18" ry="18"/>
+<text text-anchor="middle" x="634.63" y="-1115.32" font-family="Times,serif" font-size="14.00">icit_c</text>
+</g>
+<!-- e_58_center -->
+<g id="node124" class="node">
+<title>e_58_center</title>
+<polygon fill="none" stroke="black" points="987.48,-989.78 980.48,-989.78 980.48,-982.78 987.48,-982.78 987.48,-989.78"/>
+</g>
+<!-- icit_c&#45;&gt;e_58_center -->
+<g id="edge201" class="edge">
+<title>icit_c&#45;&gt;e_58_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M651.95,-1113.19C699.92,-1096.97 838.54,-1049.68 952.32,-1006.48 958.56,-1004.12 960.5,-1004.25 966.23,-1000.85 971.57,-997.67 976.99,-992.96 980.41,-989.76"/>
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+<!-- e_59_center -->
+<g id="node126" class="node">
+<title>e_59_center</title>
+<polygon fill="none" stroke="black" points="520.94,-1368.3 513.94,-1368.3 513.94,-1361.3 520.94,-1361.3 520.94,-1368.3"/>
+</g>
+<!-- icit_c&#45;&gt;e_59_center -->
+<g id="edge206" class="edge">
+<title>icit_c&#45;&gt;e_59_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M626.76,-1135.53C602.74,-1185.9 531.29,-1335.74 519.19,-1361.12"/>
+</g>
+<!-- e_4_center&#45;&gt;icit_c -->
+<g id="edge17" class="edge">
+<title>e_4_center&#45;&gt;icit_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M440.19,-980.74C451.69,-984.73 487.37,-997.81 513.24,-1015.19 535.2,-1029.95 536.91,-1038.32 556.88,-1055.68 575.17,-1071.58 596.56,-1088.92 612.27,-1101.43"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="610.35,-1104.37 620.36,-1107.84 614.69,-1098.89 610.35,-1104.37"/>
+</g>
+<!-- ac_e -->
+<g id="node20" class="node">
+<title>ac_e</title>
+<ellipse fill="none" stroke="black" cx="416.75" cy="-1683.11" rx="18" ry="18"/>
+<text text-anchor="middle" x="416.75" y="-1679.41" font-family="Times,serif" font-size="14.00">ac_e</text>
+</g>
+<!-- e_5_center -->
+<g id="node22" class="node">
+<title>e_5_center</title>
+<polygon fill="none" stroke="black" points="689.94,-1435.26 682.94,-1435.26 682.94,-1428.26 689.94,-1428.26 689.94,-1435.26"/>
+</g>
+<!-- ac_e&#45;&gt;e_5_center -->
+<g id="edge18" class="edge">
+<title>ac_e&#45;&gt;e_5_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M430.13,-1670.65C480.29,-1623.89 655.8,-1460.32 682.91,-1435.05"/>
+</g>
+<!-- e_19_target -->
+<g id="node63" class="node">
+<title>e_19_target</title>
+<ellipse fill="black" stroke="black" cx="227.74" cy="-1865.27" rx="1.8" ry="1.8"/>
+</g>
+<!-- ac_e&#45;&gt;e_19_target -->
+<g id="edge98" class="edge">
+<title>ac_e&#45;&gt;e_19_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M403.76,-1695.63C367.79,-1730.29 267.54,-1826.91 236.81,-1856.53"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="234.02,-1854.36 229.24,-1863.82 238.87,-1859.4 234.02,-1854.36"/>
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+<!-- h_e -->
+<g id="node21" class="node">
+<title>h_e</title>
+<ellipse fill="none" stroke="black" cx="991.51" cy="-1388.89" rx="18" ry="18"/>
+<text text-anchor="middle" x="991.51" y="-1385.19" font-family="Times,serif" font-size="14.00">h_e</text>
+</g>
+<!-- h_e&#45;&gt;e_5_center -->
+<g id="edge19" class="edge">
+<title>h_e&#45;&gt;e_5_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M973.34,-1391.44C912.54,-1399.98 718.43,-1427.27 689.95,-1431.27"/>
+</g>
+<!-- e_8_center -->
+<g id="node30" class="node">
+<title>e_8_center</title>
+<polygon fill="none" stroke="black" points="1202.34,-1379.26 1195.34,-1379.26 1195.34,-1372.26 1202.34,-1372.26 1202.34,-1379.26"/>
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+<!-- h_e&#45;&gt;e_8_center -->
+<g id="edge31" class="edge">
+<title>h_e&#45;&gt;e_8_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1009.55,-1387.74C1055.06,-1384.86 1172.56,-1377.43 1195.08,-1376"/>
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+<!-- h_e&#45;&gt;e_11_center -->
+<g id="edge47" class="edge">
+<title>h_e&#45;&gt;e_11_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M981.48,-1373.54C976.8,-1366.21 971.26,-1357.24 966.62,-1348.98 915.08,-1257.25 860.55,-1140.24 850.39,-1118.26"/>
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+<!-- e_16_center -->
+<g id="node58" class="node">
+<title>e_16_center</title>
+<polygon fill="none" stroke="black" points="1224.69,-1500.08 1217.69,-1500.08 1217.69,-1493.08 1224.69,-1493.08 1224.69,-1500.08"/>
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+<!-- h_e&#45;&gt;e_16_center -->
+<g id="edge87" class="edge">
+<title>h_e&#45;&gt;e_16_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M1008.03,-1396.63C1055.96,-1419.1 1193.22,-1483.46 1217.49,-1494.85"/>
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+<!-- e_18_center -->
+<g id="node62" class="node">
+<title>e_18_center</title>
+<polygon fill="none" stroke="black" points="1172.85,-1550.08 1165.85,-1550.08 1165.85,-1543.08 1172.85,-1543.08 1172.85,-1550.08"/>
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+<!-- h_e&#45;&gt;e_18_center -->
+<g id="edge94" class="edge">
+<title>h_e&#45;&gt;e_18_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1005.17,-1401C1042.58,-1434.17 1145.29,-1525.25 1165.77,-1543.41"/>
+</g>
+<!-- e_30_target -->
+<g id="node80" class="node">
+<title>e_30_target</title>
+<ellipse fill="black" stroke="black" cx="1050.19" cy="-1667.04" rx="1.8" ry="1.8"/>
+</g>
+<!-- h_e&#45;&gt;e_30_target -->
+<g id="edge109" class="edge">
+<title>h_e&#45;&gt;e_30_target</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M995.27,-1406.71C1006.3,-1458.98 1038.36,-1610.97 1047.64,-1654.97"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="1043.37,-1655.91 1049.72,-1664.79 1051.93,-1654.11 1043.37,-1655.91"/>
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+<!-- e_41_center -->
+<g id="node101" class="node">
+<title>e_41_center</title>
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+<!-- h_e&#45;&gt;e_41_center -->
+<g id="edge126" class="edge">
+<title>h_e&#45;&gt;e_41_center</title>
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+<!-- e_46_center -->
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+<!-- h_e&#45;&gt;e_46_center -->
+<g id="edge141" class="edge">
+<title>h_e&#45;&gt;e_46_center</title>
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+<!-- e_55_center -->
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+<!-- h_e&#45;&gt;e_55_center -->
+<g id="edge191" class="edge">
+<title>h_e&#45;&gt;e_55_center</title>
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+<!-- e_62_center -->
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+<!-- h_e&#45;&gt;e_62_center -->
+<g id="edge220" class="edge">
+<title>h_e&#45;&gt;e_62_center</title>
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+<!-- e_77_center -->
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+<!-- h_e&#45;&gt;e_77_center -->
+<g id="edge276" class="edge">
+<title>h_e&#45;&gt;e_77_center</title>
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+<!-- e_83_center -->
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+<!-- h_e&#45;&gt;e_83_center -->
+<g id="edge307" class="edge">
+<title>h_e&#45;&gt;e_83_center</title>
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+</g>
+<!-- e_86_center -->
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+<!-- h_e&#45;&gt;e_86_center -->
+<g id="edge314" class="edge">
+<title>h_e&#45;&gt;e_86_center</title>
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+<!-- e_87_center -->
+<g id="node149" class="node">
+<title>e_87_center</title>
+<polygon fill="none" stroke="black" points="880.82,-1511.72 873.82,-1511.72 873.82,-1504.72 880.82,-1504.72 880.82,-1511.72"/>
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+<!-- h_e&#45;&gt;e_87_center -->
+<g id="edge317" class="edge">
+<title>h_e&#45;&gt;e_87_center</title>
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+</g>
+<!-- h_e&#45;&gt;e_91_center -->
+<g id="edge336" class="edge">
+<title>h_e&#45;&gt;e_91_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M999.68,-1372.66C1025.01,-1322.36 1101.28,-1170.93 1114.2,-1145.27"/>
+</g>
+<!-- e_5_center&#45;&gt;h_c -->
+<g id="edge21" class="edge">
+<title>e_5_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M690.22,-1429.65C700.12,-1424.07 727.53,-1408.24 748.65,-1392.59 832.48,-1330.5 922.1,-1244.38 961.07,-1205.82"/>
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+</g>
+<!-- e_5_center&#45;&gt;ac_c -->
+<g id="edge20" class="edge">
+<title>e_5_center&#45;&gt;ac_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M682.59,-1429.26C659.64,-1414.37 540.06,-1336.79 488.42,-1303.29"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="490.18,-1300.26 479.89,-1297.75 486.37,-1306.13 490.18,-1300.26"/>
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+<!-- amp_c -->
+<g id="node23" class="node">
+<title>amp_c</title>
+<ellipse fill="none" stroke="black" cx="698.26" cy="-637.56" rx="18" ry="18"/>
+<text text-anchor="middle" x="698.26" y="-633.86" font-family="Times,serif" font-size="14.00">amp_c</text>
+</g>
+<!-- amp_c&#45;&gt;e_6_center -->
+<g id="edge22" class="edge">
+<title>amp_c&#45;&gt;e_6_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M688.82,-653.04C673.31,-678.5 643.28,-727.76 634.71,-741.82"/>
+</g>
+<!-- e_6_center&#45;&gt;adp_c -->
+<g id="edge24" class="edge">
+<title>e_6_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M634.57,-749.3C645.39,-767.12 694.83,-846.1 750.54,-896.67 758.52,-903.91 768.27,-910.58 777.16,-916"/>
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+</g>
+<!-- akg_c -->
+<g id="node25" class="node">
+<title>akg_c</title>
+<ellipse fill="none" stroke="black" cx="1069.22" cy="-1067.79" rx="18" ry="18"/>
+<text text-anchor="middle" x="1069.22" y="-1064.09" font-family="Times,serif" font-size="14.00">akg_c</text>
+</g>
+<!-- akg_c&#45;&gt;e_7_center -->
+<g id="edge26" class="edge">
+<title>akg_c&#45;&gt;e_7_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1087.21,-1068.96C1097.32,-1069.82 1110.13,-1071.25 1121.38,-1073.52 1125.33,-1074.32 1182.71,-1091.67 1197.88,-1096.27"/>
+</g>
+<!-- akg_c&#45;&gt;e_54_center -->
+<g id="edge185" class="edge">
+<title>akg_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1054.01,-1058.15C1034.42,-1045.17 1000.17,-1020.51 977.28,-992.98 970.85,-985.25 973.21,-980.55 966.44,-973.13 960.53,-966.67 951.5,-961.55 946.43,-958.99"/>
+</g>
+<!-- co2_c -->
+<g id="node26" class="node">
+<title>co2_c</title>
+<ellipse fill="none" stroke="black" cx="1257.36" cy="-864.4" rx="18" ry="18"/>
+<text text-anchor="middle" x="1257.36" y="-860.7" font-family="Times,serif" font-size="14.00">co2_c</text>
+</g>
+<!-- co2_c&#45;&gt;e_78_center -->
+<g id="edge281" class="edge">
+<title>co2_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1239.49,-860.46C1230.09,-858.91 1218.38,-857.83 1207.97,-859.31 1169.3,-864.83 1166,-885.88 1128.52,-896.88 1081.79,-910.6 1022.65,-917.67 1007.76,-919.3"/>
+</g>
+<!-- succoa_c -->
+<g id="node27" class="node">
+<title>succoa_c</title>
+<ellipse fill="none" stroke="black" cx="1023.77" cy="-1259.8" rx="18" ry="18"/>
+<text text-anchor="middle" x="1023.77" y="-1256.1" font-family="Times,serif" font-size="14.00">succoa_c</text>
+</g>
+<!-- e_7_center&#45;&gt;nadh_c -->
+<g id="edge30" class="edge">
+<title>e_7_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1197.94,-1094.32C1195.21,-1092.01 1191.22,-1088.63 1186.96,-1085.01"/>
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+</g>
+<!-- e_7_center&#45;&gt;co2_c -->
+<g id="edge28" class="edge">
+<title>e_7_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1202.41,-1093.72C1207.87,-1070.93 1237.41,-947.64 1250.78,-891.85"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1254.23,-892.49 1253.15,-881.95 1247.42,-890.85 1254.23,-892.49"/>
+</g>
+<!-- e_7_center&#45;&gt;succoa_c -->
+<g id="edge29" class="edge">
+<title>e_7_center&#45;&gt;succoa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1197.82,-1100.77C1178.24,-1118.66 1086.31,-1202.65 1044.53,-1240.83"/>
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+</g>
+<!-- akg_e -->
+<g id="node29" class="node">
+<title>akg_e</title>
+<ellipse fill="none" stroke="black" cx="1460.4" cy="-1630.69" rx="18" ry="18"/>
+<text text-anchor="middle" x="1460.4" y="-1626.99" font-family="Times,serif" font-size="14.00">akg_e</text>
+</g>
+<!-- akg_e&#45;&gt;e_8_center -->
+<g id="edge32" class="edge">
+<title>akg_e&#45;&gt;e_8_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1446.27,-1618.85C1425.54,-1601.34 1385.86,-1567.28 1353.75,-1536.54 1290.47,-1475.96 1218.19,-1397.04 1202.11,-1379.38"/>
+</g>
+<!-- e_21_target -->
+<g id="node65" class="node">
+<title>e_21_target</title>
+<ellipse fill="black" stroke="black" cx="1658.89" cy="-1816.17" rx="1.8" ry="1.8"/>
+</g>
+<!-- akg_e&#45;&gt;e_21_target -->
+<g id="edge100" class="edge">
+<title>akg_e&#45;&gt;e_21_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1473.73,-1643.15C1511.38,-1678.33 1617.84,-1777.81 1649.75,-1807.62"/>
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+</g>
+<!-- e_8_center&#45;&gt;h_c -->
+<g id="edge34" class="edge">
+<title>e_8_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1195.06,-1372.47C1172.21,-1352.53 1051.91,-1247.56 1002.39,-1204.36"/>
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+</g>
+<!-- e_8_center&#45;&gt;akg_c -->
+<g id="edge33" class="edge">
+<title>e_8_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1197.2,-1371.87C1185.08,-1343.07 1109,-1162.32 1080.23,-1093.95"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1083.44,-1092.56 1076.34,-1084.7 1076.99,-1095.28 1083.44,-1092.56"/>
+</g>
+<!-- etoh_c -->
+<g id="node31" class="node">
+<title>etoh_c</title>
+<ellipse fill="none" stroke="black" cx="1367.72" cy="-1522.79" rx="18" ry="18"/>
+<text text-anchor="middle" x="1367.72" y="-1519.09" font-family="Times,serif" font-size="14.00">etoh_c</text>
+</g>
+<!-- etoh_c&#45;&gt;e_9_center -->
+<g id="edge36" class="edge">
+<title>etoh_c&#45;&gt;e_9_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1361.81,-1505.78C1344.06,-1454.66 1291.9,-1304.4 1283.06,-1278.96"/>
+</g>
+<!-- e_9_center&#45;&gt;acald_c -->
+<g id="edge37" class="edge">
+<title>e_9_center&#45;&gt;acald_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1285.68,-1275.97C1312.04,-1280.66 1465.07,-1307.91 1529.21,-1319.32"/>
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+</g>
+<!-- e_9_center&#45;&gt;h_c -->
+<g id="edge39" class="edge">
+<title>e_9_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1277.98,-1274.14C1250.1,-1265.84 1076.43,-1214.14 1008.38,-1193.88"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1008.98,-1190.41 998.4,-1190.91 1006.98,-1197.12 1008.98,-1190.41"/>
+</g>
+<!-- e_9_center&#45;&gt;nadh_c -->
+<g id="edge38" class="edge">
+<title>e_9_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1279.76,-1271.65C1267.91,-1250.41 1206.95,-1141.19 1179.18,-1091.44"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1182.18,-1089.63 1174.25,-1082.61 1176.07,-1093.04 1182.18,-1089.63"/>
+</g>
+<!-- pi_c -->
+<g id="node33" class="node">
+<title>pi_c</title>
+<ellipse fill="none" stroke="black" cx="831.73" cy="-982.39" rx="18" ry="18"/>
+<text text-anchor="middle" x="831.73" y="-978.69" font-family="Times,serif" font-size="14.00">pi_c</text>
+</g>
+<!-- pi_c&#45;&gt;e_11_center -->
+<g id="edge45" class="edge">
+<title>pi_c&#45;&gt;e_11_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M834.06,-1000.49C838.09,-1031.9 846.15,-1094.65 848.22,-1110.77"/>
+</g>
+<!-- pi_c&#45;&gt;e_48_center -->
+<g id="edge150" class="edge">
+<title>pi_c&#45;&gt;e_48_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M846.76,-971.79C887.48,-943.05 998.37,-864.8 1019.64,-849.79"/>
+</g>
+<!-- pi_c&#45;&gt;e_81_center -->
+<g id="edge298" class="edge">
+<title>pi_c&#45;&gt;e_81_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M823.63,-998.48C807.19,-1031.13 770.71,-1103.58 761.84,-1121.18"/>
+</g>
+<!-- e_10_center&#45;&gt;h_c -->
+<g id="edge44" class="edge">
+<title>e_10_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M761,-1061.13C768.33,-1066.27 784.85,-1077.51 799.79,-1085.18 823.55,-1097.38 831.62,-1095.79 855.41,-1107.91 892.47,-1126.8 932.98,-1152.98 957.71,-1169.64"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="955.34,-1173.32 966.07,-1175.32 960.26,-1166.08 955.34,-1173.32"/>
+</g>
+<!-- e_10_center&#45;&gt;adp_c -->
+<g id="edge43" class="edge">
+<title>e_10_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M758.68,-1054.77C761.87,-1047.3 769.4,-1029.62 775.65,-1014.75 778.23,-1008.6 779.18,-1007.18 781.4,-1000.9 786.46,-986.62 791.31,-970.44 795.06,-957.12"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="799.37,-957.95 797.83,-947.14 790.94,-955.61 799.37,-957.95"/>
+</g>
+<!-- e_10_center&#45;&gt;pi_c -->
+<g id="edge42" class="edge">
+<title>e_10_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M760.73,-1054.72C769.8,-1045.48 794.11,-1020.71 811.77,-1002.73"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="814.98,-1005.7 818.86,-995.5 808.73,-999.57 814.98,-1005.7"/>
+</g>
+<!-- e_11_center&#45;&gt;h_c -->
+<g id="edge50" class="edge">
+<title>e_11_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M852.25,-1116.51C866.77,-1124.32 922.54,-1154.29 955.75,-1172.15"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="954.4,-1175.39 964.87,-1177.04 957.72,-1169.23 954.4,-1175.39"/>
+</g>
+<!-- e_11_center&#45;&gt;atp_c -->
+<g id="edge49" class="edge">
+<title>e_11_center&#45;&gt;atp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M847.39,-1110.97C839.11,-1088.2 794.17,-964.57 774.13,-909.44"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="777.4,-908.19 770.69,-899.98 770.82,-910.58 777.4,-908.19"/>
+</g>
+<!-- e_11_center&#45;&gt;h2o_c -->
+<g id="edge48" class="edge">
+<title>e_11_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M847.09,-1110.78C840.15,-1094.61 811.62,-1030.83 775.68,-987.03 771.6,-982.06 766.7,-977.22 761.84,-972.89"/>
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+</g>
+<!-- gln__L_c -->
+<g id="node36" class="node">
+<title>gln__L_c</title>
+<ellipse fill="none" stroke="black" cx="748.84" cy="-827.41" rx="18" ry="18"/>
+<text text-anchor="middle" x="748.84" y="-823.71" font-family="Times,serif" font-size="14.00">gln__L_c</text>
+</g>
+<!-- gln__L_c&#45;&gt;e_12_center -->
+<g id="edge51" class="edge">
+<title>gln__L_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M767.23,-827.44C818.26,-827.53 959.51,-827.77 984.48,-827.81"/>
+</g>
+<!-- gln__L_c&#45;&gt;e_53_center -->
+<g id="edge182" class="edge">
+<title>gln__L_c&#45;&gt;e_53_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M730.9,-829.49C693.69,-833.78 610.01,-843.45 590.91,-845.66"/>
+</g>
+<!-- gln__L_c&#45;&gt;e_54_center -->
+<g id="edge187" class="edge">
+<title>gln__L_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M764.54,-836.28C790.57,-851.16 844.01,-882.49 886.84,-912.64 907.31,-927.05 930.22,-946.45 938.97,-954"/>
+</g>
+<!-- 3pg_c -->
+<g id="node37" class="node">
+<title>3pg_c</title>
+<ellipse fill="none" stroke="black" cx="815.53" cy="-556.84" rx="18" ry="18"/>
+<text text-anchor="middle" x="815.53" y="-553.14" font-family="Times,serif" font-size="14.00">3pg_c</text>
+</g>
+<!-- 3pg_c&#45;&gt;e_12_center -->
+<g id="edge52" class="edge">
+<title>3pg_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M825.31,-572.18C858.86,-624.81 968.14,-796.23 985.84,-824"/>
+</g>
+<!-- 3pg_c&#45;&gt;e_74_center -->
+<g id="edge268" class="edge">
+<title>3pg_c&#45;&gt;e_74_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M806.73,-572.76C789.53,-603.87 752.36,-671.11 743.33,-687.43"/>
+</g>
+<!-- f6p_c -->
+<g id="node38" class="node">
+<title>f6p_c</title>
+<ellipse fill="none" stroke="black" cx="1038.14" cy="-546.2" rx="18" ry="18"/>
+<text text-anchor="middle" x="1038.14" y="-542.5" font-family="Times,serif" font-size="14.00">f6p_c</text>
+</g>
+<!-- f6p_c&#45;&gt;e_12_center -->
+<g id="edge53" class="edge">
+<title>f6p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1034.94,-564.24C1024.8,-621.54 993.7,-797.19 988.9,-824.29"/>
+</g>
+<!-- f6p_c&#45;&gt;e_71_center -->
+<g id="edge258" class="edge">
+<title>f6p_c&#45;&gt;e_71_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M1029.09,-561.84C1001.06,-610.32 916.67,-756.28 902.38,-781.01"/>
+</g>
+<!-- pyr_c -->
+<g id="node39" class="node">
+<title>pyr_c</title>
+<ellipse fill="none" stroke="black" cx="1207.84" cy="-878.91" rx="18" ry="18"/>
+<text text-anchor="middle" x="1207.84" y="-875.21" font-family="Times,serif" font-size="14.00">pyr_c</text>
+</g>
+<!-- pyr_c&#45;&gt;e_12_center -->
+<g id="edge54" class="edge">
+<title>pyr_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1190.29,-873.93C1174.28,-869.45 1149.95,-862.8 1128.63,-857.68 1074.85,-844.76 1008.8,-831.79 992.2,-828.57"/>
+</g>
+<!-- pyr_c&#45;&gt;e_70_center -->
+<g id="edge252" class="edge">
+<title>pyr_c&#45;&gt;e_70_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1210.23,-897.07C1210.72,-901.54 1211.17,-906.31 1211.41,-910.76 1213.22,-942.96 1202.52,-981.25 1198.96,-992.95"/>
+</g>
+<!-- pyr_c&#45;&gt;e_72_center -->
+<g id="edge263" class="edge">
+<title>pyr_c&#45;&gt;e_72_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1213.13,-896.28C1228.55,-946.89 1272.84,-1092.24 1280.34,-1116.84"/>
+</g>
+<!-- pyr_c&#45;&gt;e_80_center -->
+<g id="edge292" class="edge">
+<title>pyr_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1190.8,-872.91C1174.94,-867.67 1150.52,-860.48 1128.63,-857.68 1085.58,-852.18 942.71,-858.12 918.48,-859.18"/>
+</g>
+<!-- r5p_c -->
+<g id="node40" class="node">
+<title>r5p_c</title>
+<ellipse fill="none" stroke="black" cx="1123.47" cy="-472.63" rx="18" ry="18"/>
+<text text-anchor="middle" x="1123.47" y="-468.93" font-family="Times,serif" font-size="14.00">r5p_c</text>
+</g>
+<!-- r5p_c&#45;&gt;e_12_center -->
+<g id="edge56" class="edge">
+<title>r5p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1116.95,-489.76C1091.85,-555.72 1002.2,-791.22 989.72,-824.01"/>
+</g>
+<!-- ru5p__D_c -->
+<g id="node122" class="node">
+<title>ru5p__D_c</title>
+<ellipse fill="none" stroke="black" cx="1303.98" cy="-377.26" rx="18" ry="18"/>
+<text text-anchor="middle" x="1303.98" y="-373.56" font-family="Times,serif" font-size="14.00">ru5p__D_c</text>
+</g>
+<!-- r5p_c&#45;&gt;ru5p__D_c -->
+<g id="edge312" class="edge">
+<title>r5p_c&#45;&gt;ru5p__D_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1139.49,-464.16C1170.94,-447.55 1240.95,-410.56 1278.7,-390.62"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1280.79,-393.47 1288,-385.71 1277.52,-387.29 1280.79,-393.47"/>
+</g>
+<!-- e_92_center -->
+<g id="node155" class="node">
+<title>e_92_center</title>
+<polygon fill="none" stroke="black" points="1120.35,-228.53 1113.35,-228.53 1113.35,-221.53 1120.35,-221.53 1120.35,-228.53"/>
+</g>
+<!-- r5p_c&#45;&gt;e_92_center -->
+<g id="edge342" class="edge">
+<title>r5p_c&#45;&gt;e_92_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1123.76,-454.27C1124.14,-423.75 1124.57,-360.65 1122.57,-307.31 1121.43,-276.97 1118.26,-240.45 1117.2,-228.79"/>
+</g>
+<!-- e4p_c -->
+<g id="node41" class="node">
+<title>e4p_c</title>
+<ellipse fill="none" stroke="black" cx="1053.21" cy="-471.31" rx="18" ry="18"/>
+<text text-anchor="middle" x="1053.21" y="-467.61" font-family="Times,serif" font-size="14.00">e4p_c</text>
+</g>
+<!-- e4p_c&#45;&gt;e_12_center -->
+<g id="edge57" class="edge">
+<title>e4p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1055.8,-489.2C1057.65,-504.4 1059.51,-526.78 1057.74,-546.26 1047.11,-663.08 998.29,-800.49 989.6,-824.23"/>
+</g>
+<!-- e_93_center -->
+<g id="node156" class="node">
+<title>e_93_center</title>
+<polygon fill="none" stroke="black" points="1119.37,-317.51 1112.37,-317.51 1112.37,-310.51 1119.37,-310.51 1119.37,-317.51"/>
+</g>
+<!-- e4p_c&#45;&gt;e_93_center -->
+<g id="edge345" class="edge">
+<title>e4p_c&#45;&gt;e_93_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1059.91,-454.47C1074.18,-418.65 1106.87,-336.6 1114.33,-317.87"/>
+</g>
+<!-- g3p_c -->
+<g id="node42" class="node">
+<title>g3p_c</title>
+<ellipse fill="none" stroke="black" cx="1005.27" cy="-459.71" rx="18" ry="18"/>
+<text text-anchor="middle" x="1005.27" y="-456.01" font-family="Times,serif" font-size="14.00">g3p_c</text>
+</g>
+<!-- g3p_c&#45;&gt;e_12_center -->
+<g id="edge59" class="edge">
+<title>g3p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1004.44,-477.71C1001.25,-546.71 989.93,-792.02 988.44,-824.3"/>
+</g>
+<!-- g3p_c&#45;&gt;e_48_center -->
+<g id="edge152" class="edge">
+<title>g3p_c&#45;&gt;e_48_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1006.11,-477.88C1009.42,-549.42 1021.44,-809.35 1023.02,-843.56"/>
+</g>
+<!-- e_90_center -->
+<g id="node153" class="node">
+<title>e_90_center</title>
+<polygon fill="none" stroke="black" points="1050.03,-283.06 1043.03,-283.06 1043.03,-276.06 1050.03,-276.06 1050.03,-283.06"/>
+</g>
+<!-- g3p_c&#45;&gt;e_90_center -->
+<g id="edge332" class="edge">
+<title>g3p_c&#45;&gt;e_90_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1009.3,-442.11C1018.59,-401.56 1041.05,-303.48 1045.68,-283.25"/>
+</g>
+<!-- g6p_c -->
+<g id="node43" class="node">
+<title>g6p_c</title>
+<ellipse fill="none" stroke="black" cx="1195.72" cy="-670.74" rx="18" ry="18"/>
+<text text-anchor="middle" x="1195.72" y="-667.04" font-family="Times,serif" font-size="14.00">g6p_c</text>
+</g>
+<!-- g6p_c&#45;&gt;f6p_c -->
+<g id="edge266" class="edge">
+<title>g6p_c&#45;&gt;f6p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M1181.45,-659.47C1154.05,-637.81 1093.85,-590.23 1060.86,-564.15"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.4" points="1062.94,-560.89 1052.71,-557.71 1058.17,-566.93 1062.94,-560.89"/>
+</g>
+<!-- g6p_c&#45;&gt;e_12_center -->
+<g id="edge60" class="edge">
+<title>g6p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1181.13,-681.78C1138.34,-714.19 1014.72,-807.79 991.92,-825.06"/>
+</g>
+<!-- e_47_center -->
+<g id="node110" class="node">
+<title>e_47_center</title>
+<polygon fill="none" stroke="black" points="1208.21,-920.96 1201.21,-920.96 1201.21,-913.96 1208.21,-913.96 1208.21,-920.96"/>
+</g>
+<!-- g6p_c&#45;&gt;e_47_center -->
+<g id="edge146" class="edge">
+<title>g6p_c&#45;&gt;e_47_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1192.55,-688.72C1186.73,-725 1175.97,-809.38 1188.24,-878.78 1190.63,-892.29 1198.39,-906.82 1202.35,-913.58"/>
+</g>
+<!-- pep_c -->
+<g id="node44" class="node">
+<title>pep_c</title>
+<ellipse fill="none" stroke="black" cx="1071.25" cy="-682.94" rx="18" ry="18"/>
+<text text-anchor="middle" x="1071.25" y="-679.24" font-family="Times,serif" font-size="14.00">pep_c</text>
+</g>
+<!-- pep_c&#45;&gt;e_12_center -->
+<g id="edge62" class="edge">
+<title>pep_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1062.21,-698.72C1043.22,-731.87 1000.14,-807.1 990.3,-824.28"/>
+</g>
+<!-- e_44_center -->
+<g id="node105" class="node">
+<title>e_44_center</title>
+<polygon fill="none" stroke="black" points="1274.78,-525.21 1267.78,-525.21 1267.78,-518.21 1274.78,-518.21 1274.78,-525.21"/>
+</g>
+<!-- pep_c&#45;&gt;e_44_center -->
+<g id="edge135" class="edge">
+<title>pep_c&#45;&gt;e_44_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1085.31,-671.6C1126.57,-638.34 1245.78,-542.26 1267.77,-524.53"/>
+</g>
+<!-- e_49_center -->
+<g id="node113" class="node">
+<title>e_49_center</title>
+<polygon fill="none" stroke="black" points="1359.54,-592.38 1352.54,-592.38 1352.54,-585.38 1359.54,-585.38 1359.54,-592.38"/>
+</g>
+<!-- pep_c&#45;&gt;e_49_center -->
+<g id="edge157" class="edge">
+<title>pep_c&#45;&gt;e_49_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M1088.63,-677.19C1145.63,-658.37 1324.79,-599.2 1352.44,-590.07"/>
+</g>
+<!-- pep_c&#45;&gt;e_78_center -->
+<g id="edge282" class="edge">
+<title>pep_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1067.79,-700.63C1061.5,-731.92 1047.22,-798.9 1029.89,-853.99 1022.25,-878.28 1010.09,-906.46 1005.8,-916.17"/>
+</g>
+<!-- pep_c&#45;&gt;e_82_center -->
+<g id="edge303" class="edge">
+<title>pep_c&#45;&gt;e_82_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M1063.97,-699.49C1044.15,-744.56 990.06,-867.6 980.09,-890.27"/>
+</g>
+<!-- oaa_c -->
+<g id="node45" class="node">
+<title>oaa_c</title>
+<ellipse fill="none" stroke="black" cx="952.47" cy="-986.88" rx="18" ry="18"/>
+<text text-anchor="middle" x="952.47" y="-983.18" font-family="Times,serif" font-size="14.00">oaa_c</text>
+</g>
+<!-- oaa_c&#45;&gt;e_12_center -->
+<g id="edge63" class="edge">
+<title>oaa_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M955.54,-968.78C959.04,-948.73 965.14,-915.5 971.8,-887.19 976.8,-865.94 984.29,-840.86 987.13,-831.54"/>
+</g>
+<!-- oaa_c&#45;&gt;e_14_center -->
+<g id="edge77" class="edge">
+<title>oaa_c&#45;&gt;e_14_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M937.13,-996.51C904.04,-1017.27 827.56,-1065.26 810.09,-1076.22"/>
+</g>
+<!-- oaa_c&#45;&gt;e_79_center -->
+<g id="edge287" class="edge">
+<title>oaa_c&#45;&gt;e_79_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M955.05,-969.04C961.25,-926.04 976.76,-818.66 979.84,-797.29"/>
+</g>
+<!-- nadph_c -->
+<g id="node46" class="node">
+<title>nadph_c</title>
+<ellipse fill="none" stroke="black" cx="1130.02" cy="-921.3" rx="18" ry="18"/>
+<text text-anchor="middle" x="1130.02" y="-917.6" font-family="Times,serif" font-size="14.00">nadph_c</text>
+</g>
+<!-- nadph_c&#45;&gt;e_12_center -->
+<g id="edge65" class="edge">
+<title>nadph_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1112.58,-915.6C1103.52,-912.34 1092.42,-907.88 1083.05,-902.71 1043.76,-881.02 1003.93,-843.26 991.92,-831.45"/>
+</g>
+<!-- nadph_c&#45;&gt;e_54_center -->
+<g id="edge188" class="edge">
+<title>nadph_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1112.05,-924.74C1069.92,-932.81 966.75,-952.57 946.23,-956.5"/>
+</g>
+<!-- nadph_c&#45;&gt;e_67_center -->
+<g id="edge246" class="edge">
+<title>nadph_c&#45;&gt;e_67_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1147.67,-924.84C1186.07,-932.54 1275.28,-950.44 1294.34,-954.26"/>
+</g>
+<!-- glu__L_c -->
+<g id="node47" class="node">
+<title>glu__L_c</title>
+<ellipse fill="none" stroke="black" cx="761.8" cy="-1000.87" rx="18" ry="18"/>
+<text text-anchor="middle" x="761.8" y="-997.17" font-family="Times,serif" font-size="14.00">glu__L_c</text>
+</g>
+<!-- glu__L_c&#45;&gt;e_12_center -->
+<g id="edge66" class="edge">
+<title>glu__L_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M776.14,-989.3C797.27,-972.29 838.1,-939.64 873.44,-912.64 916.76,-879.53 970.43,-840.68 984.67,-830.41"/>
+</g>
+<!-- glu__L_c&#45;&gt;e_50_center -->
+<g id="edge162" class="edge">
+<title>glu__L_c&#45;&gt;e_50_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M747.22,-989.57C740.24,-983.83 731.99,-976.51 725.38,-969.14 718.81,-961.81 712.58,-951.99 709.46,-946.81"/>
+</g>
+<!-- glu__L_c&#45;&gt;e_52_center -->
+<g id="edge176" class="edge">
+<title>glu__L_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M776.79,-990.55C804.4,-971.52 861.84,-931.94 876.61,-921.77"/>
+</g>
+<!-- nadp_c -->
+<g id="node48" class="node">
+<title>nadp_c</title>
+<ellipse fill="none" stroke="black" cx="1128.57" cy="-877.28" rx="18" ry="18"/>
+<text text-anchor="middle" x="1128.57" y="-873.58" font-family="Times,serif" font-size="14.00">nadp_c</text>
+</g>
+<!-- nadp_c&#45;&gt;e_47_center -->
+<g id="edge145" class="edge">
+<title>nadp_c&#45;&gt;e_47_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1144.72,-885.8C1162.88,-895.38 1191.14,-910.29 1201.09,-915.54"/>
+</g>
+<!-- nadp_c&#45;&gt;e_52_center -->
+<g id="edge175" class="edge">
+<title>nadp_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1110.71,-880.31C1058.64,-889.12 909.11,-914.43 883.8,-918.72"/>
+</g>
+<!-- e_56_center -->
+<g id="node123" class="node">
+<title>e_56_center</title>
+<polygon fill="none" stroke="black" points="1270.63,-674.19 1263.63,-674.19 1263.63,-667.19 1270.63,-667.19 1270.63,-674.19"/>
+</g>
+<!-- nadp_c&#45;&gt;e_56_center -->
+<g id="edge196" class="edge">
+<title>nadp_c&#45;&gt;e_56_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1138.76,-862.09C1167.76,-818.85 1249.63,-696.79 1264.72,-674.28"/>
+</g>
+<!-- nadp_c&#45;&gt;e_58_center -->
+<g id="edge202" class="edge">
+<title>nadp_c&#45;&gt;e_58_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1114.26,-888.77C1108.72,-893.17 1102.32,-898.21 1096.45,-902.71 1053.99,-935.28 1001.44,-973.59 987.5,-983.72"/>
+</g>
+<!-- e_65_center -->
+<g id="node132" class="node">
+<title>e_65_center</title>
+<polygon fill="none" stroke="black" points="1260.89,-1014.85 1253.89,-1014.85 1253.89,-1007.85 1260.89,-1007.85 1260.89,-1014.85"/>
+</g>
+<!-- nadp_c&#45;&gt;e_65_center -->
+<g id="edge234" class="edge">
+<title>nadp_c&#45;&gt;e_65_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1141.4,-890.63C1169.91,-920.3 1237.33,-990.48 1253.74,-1007.56"/>
+</g>
+<!-- nadp_c&#45;&gt;e_91_center -->
+<g id="edge335" class="edge">
+<title>nadp_c&#45;&gt;e_91_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1120.3,-893.49C1116.58,-901.58 1112.56,-911.63 1110.42,-921.11 1093.59,-995.72 1092.58,-1017.04 1101.65,-1092.99 1103.69,-1110.11 1111.06,-1129.48 1114.4,-1137.63"/>
+</g>
+<!-- e_12_center&#45;&gt;coa_c -->
+<g id="edge67" class="edge">
+<title>e_12_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M988.24,-831.43C988.1,-853.22 988.11,-969.33 1003.27,-1062.35 1004.16,-1067.79 1005.43,-1073.53 1006.81,-1079.01"/>
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+</g>
+<!-- e_12_center&#45;&gt;h_c -->
+<g id="edge73" class="edge">
+<title>e_12_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M988.36,-831.57C988.72,-848.63 990.21,-920.56 990.68,-979.58 991.18,-1043.26 986.35,-1117.88 983.36,-1157.56"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="979.86,-1157.32 982.58,-1167.56 986.84,-1157.86 979.86,-1157.32"/>
+</g>
+<!-- e_12_center&#45;&gt;nadh_c -->
+<g id="edge69" class="edge">
+<title>e_12_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M991.06,-831.57C1008.94,-855.69 1108.25,-989.65 1148.46,-1043.89"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1145.84,-1046.23 1154.61,-1052.18 1151.46,-1042.06 1145.84,-1046.23"/>
+</g>
+<!-- e_12_center&#45;&gt;adp_c -->
+<g id="edge71" class="edge">
+<title>e_12_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M984.69,-829.93C974.74,-835.77 945.93,-852.61 921.67,-866.04 889.4,-883.91 851.81,-903.83 827.59,-916.56"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="825.93,-913.48 818.7,-921.22 829.18,-919.68 825.93,-913.48"/>
+</g>
+<!-- e_12_center&#45;&gt;akg_c -->
+<g id="edge68" class="edge">
+<title>e_12_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M989.55,-831.58C997.52,-855.22 1040.89,-983.8 1060.08,-1040.69"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1056.85,-1042.08 1063.36,-1050.43 1063.48,-1039.84 1056.85,-1042.08"/>
+</g>
+<!-- e_12_center&#45;&gt;pi_c -->
+<g id="edge70" class="edge">
+<title>e_12_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M984.71,-831.33C967.21,-848.62 889.67,-925.18 852.17,-962.21"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="849.47,-959.95 844.82,-969.47 854.39,-964.93 849.47,-959.95"/>
+</g>
+<!-- e_12_center&#45;&gt;nadp_c -->
+<g id="edge72" class="edge">
+<title>e_12_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M992.2,-828.94C999.61,-831.07 1016.15,-835.93 1029.89,-840.59 1054.51,-848.93 1082.23,-859.33 1102.01,-866.92"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1100.98,-870.28 1111.57,-870.61 1103.5,-863.75 1100.98,-870.28"/>
+</g>
+<!-- co2_e -->
+<g id="node50" class="node">
+<title>co2_e</title>
+<ellipse fill="none" stroke="black" cx="1628.62" cy="-713.55" rx="18" ry="18"/>
+<text text-anchor="middle" x="1628.62" y="-709.85" font-family="Times,serif" font-size="14.00">co2_e</text>
+</g>
+<!-- co2_e&#45;&gt;co2_c -->
+<g id="edge74" class="edge">
+<title>co2_e&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1611.7,-720.42C1552.75,-744.38 1356.06,-824.29 1284.06,-853.55"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1282.32,-850.48 1274.37,-857.48 1284.96,-856.96 1282.32,-850.48"/>
+</g>
+<!-- e_22_target -->
+<g id="node66" class="node">
+<title>e_22_target</title>
+<ellipse fill="black" stroke="black" cx="1877.52" cy="-612.17" rx="1.8" ry="1.8"/>
+</g>
+<!-- co2_e&#45;&gt;e_22_target -->
+<g id="edge101" class="edge">
+<title>co2_e&#45;&gt;e_22_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1645.34,-706.74C1692.55,-687.51 1826.04,-633.14 1866.05,-616.84"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1867.59,-620 1875.53,-612.98 1864.95,-613.52 1867.59,-620"/>
+</g>
+<!-- e_14_center&#45;&gt;coa_c -->
+<g id="edge79" class="edge">
+<title>e_14_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M810.11,-1078.96C830.91,-1081.76 936.09,-1095.91 987.13,-1102.77"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="986.77,-1106.25 997.15,-1104.12 987.71,-1099.31 986.77,-1106.25"/>
+</g>
+<!-- e_14_center&#45;&gt;h_c -->
+<g id="edge80" class="edge">
+<title>e_14_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M810.06,-1080.6C818.15,-1085.43 838.49,-1097.58 855.41,-1107.91 890.92,-1129.59 931.84,-1155.02 957.08,-1170.76"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="955.3,-1173.78 965.63,-1176.1 959,-1167.84 955.3,-1173.78"/>
+</g>
+<!-- e_14_center&#45;&gt;cit_c -->
+<g id="edge78" class="edge">
+<title>e_14_center&#45;&gt;cit_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M802.61,-1077.85C774.19,-1073.27 597.53,-1044.8 527.68,-1033.54"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="527.85,-1030.03 517.42,-1031.89 526.74,-1036.94 527.85,-1030.03"/>
+</g>
+<!-- q8h2_c -->
+<g id="node52" class="node">
+<title>q8h2_c</title>
+<ellipse fill="none" stroke="black" cx="812.2" cy="-1566.75" rx="18" ry="18"/>
+<text text-anchor="middle" x="812.2" y="-1563.05" font-family="Times,serif" font-size="14.00">q8h2_c</text>
+</g>
+<!-- q8h2_c&#45;&gt;e_15_center -->
+<g id="edge81" class="edge">
+<title>q8h2_c&#45;&gt;e_15_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M805.59,-1549.74C789.95,-1509.46 751.37,-1410.13 743.41,-1389.63"/>
+</g>
+<!-- e_43_center -->
+<g id="node104" class="node">
+<title>e_43_center</title>
+<polygon fill="none" stroke="black" points="707.93,-1708.25 700.93,-1708.25 700.93,-1701.25 707.93,-1701.25 707.93,-1708.25"/>
+</g>
+<!-- q8h2_c&#45;&gt;e_43_center -->
+<g id="edge130" class="edge">
+<title>q8h2_c&#45;&gt;e_43_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M796.86,-1576.17C787.24,-1582.58 775.01,-1591.69 766.01,-1601.73 735.42,-1635.87 711.93,-1687.41 705.93,-1701.23"/>
+</g>
+<!-- o2_c -->
+<g id="node53" class="node">
+<title>o2_c</title>
+<ellipse fill="none" stroke="black" cx="496.9" cy="-1726.81" rx="18" ry="18"/>
+<text text-anchor="middle" x="496.9" y="-1723.11" font-family="Times,serif" font-size="14.00">o2_c</text>
+</g>
+<!-- o2_c&#45;&gt;e_15_center -->
+<g id="edge83" class="edge">
+<title>o2_c&#45;&gt;e_15_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M507.43,-1712.16C551.04,-1651.49 716.27,-1421.63 739.29,-1389.6"/>
+</g>
+<!-- q8_c -->
+<g id="node54" class="node">
+<title>q8_c</title>
+<ellipse fill="none" stroke="black" cx="763.56" cy="-1560.62" rx="18" ry="18"/>
+<text text-anchor="middle" x="763.56" y="-1556.92" font-family="Times,serif" font-size="14.00">q8_c</text>
+</g>
+<!-- q8_c&#45;&gt;e_66_center -->
+<g id="edge239" class="edge">
+<title>q8_c&#45;&gt;e_66_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M776.05,-1547.62C817.15,-1504.84 946.85,-1369.83 969.82,-1345.92"/>
+</g>
+<!-- e_88_center -->
+<g id="node150" class="node">
+<title>e_88_center</title>
+<polygon fill="none" stroke="black" points="668.49,-1684.22 661.49,-1684.22 661.49,-1677.22 668.49,-1677.22 668.49,-1684.22"/>
+</g>
+<!-- q8_c&#45;&gt;e_88_center -->
+<g id="edge321" class="edge">
+<title>q8_c&#45;&gt;e_88_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M751.86,-1574.87C729.22,-1602.46 680.52,-1661.8 667.98,-1677.08"/>
+</g>
+<!-- e_15_center&#45;&gt;h2o_c -->
+<g id="edge84" class="edge">
+<title>e_15_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M742.13,-1382.16C742.61,-1371.82 743.93,-1341.92 744.37,-1317.05 744.47,-1311.09 744.41,-1309.6 744.37,-1303.65 743.51,-1184.68 741.02,-1042.88 739.91,-983.61"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="743.4,-983.46 739.72,-973.53 736.41,-983.59 743.4,-983.46"/>
+</g>
+<!-- e_15_center&#45;&gt;h_e -->
+<g id="edge86" class="edge">
+<title>e_15_center&#45;&gt;h_e</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M745.48,-1385.93C768.96,-1386.21 903.51,-1387.83 963.11,-1388.54"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="963.28,-1392.05 973.32,-1388.67 963.36,-1385.05 963.28,-1392.05"/>
+</g>
+<!-- e_15_center&#45;&gt;q8_c -->
+<g id="edge85" class="edge">
+<title>e_15_center&#45;&gt;q8_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M742.41,-1389.54C744.65,-1407.69 754.72,-1489.14 760.11,-1532.79"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="756.65,-1533.26 761.35,-1542.76 763.59,-1532.4 756.65,-1533.26"/>
+</g>
+<!-- lac__D_e -->
+<g id="node56" class="node">
+<title>lac__D_e</title>
+<ellipse fill="none" stroke="black" cx="1432.18" cy="-1785.04" rx="18" ry="18"/>
+<text text-anchor="middle" x="1432.18" y="-1781.34" font-family="Times,serif" font-size="14.00">lac__D_e</text>
+</g>
+<!-- lac__D_e&#45;&gt;e_16_center -->
+<g id="edge88" class="edge">
+<title>lac__D_e&#45;&gt;e_16_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M1421.43,-1770.34C1381.79,-1716.15 1245.06,-1529.21 1223.94,-1500.34"/>
+</g>
+<!-- e_32_target -->
+<g id="node83" class="node">
+<title>e_32_target</title>
+<ellipse fill="black" stroke="black" cx="1591.94" cy="-2000.26" rx="1.8" ry="1.8"/>
+</g>
+<!-- lac__D_e&#45;&gt;e_32_target -->
+<g id="edge111" class="edge">
+<title>lac__D_e&#45;&gt;e_32_target</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1442.91,-1799.5C1473.21,-1840.32 1558.9,-1955.75 1584.58,-1990.34"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="1581.19,-1993.12 1590.66,-1998.54 1588.21,-1987.9 1581.19,-1993.12"/>
+</g>
+<!-- lac__D_c -->
+<g id="node57" class="node">
+<title>lac__D_c</title>
+<ellipse fill="none" stroke="black" cx="1392.51" cy="-1386.26" rx="18" ry="18"/>
+<text text-anchor="middle" x="1392.51" y="-1382.56" font-family="Times,serif" font-size="14.00">lac__D_c</text>
+</g>
+<!-- lac__D_c&#45;&gt;e_60_center -->
+<g id="edge209" class="edge">
+<title>lac__D_c&#45;&gt;e_60_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M1382.32,-1370.76C1362.29,-1340.12 1316.64,-1269.44 1281.18,-1208.27 1271.49,-1191.56 1260.9,-1171.03 1256.74,-1162.85"/>
+</g>
+<!-- e_16_center&#45;&gt;h_c -->
+<g id="edge90" class="edge">
+<title>e_16_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M1218.76,-1492.92C1203.38,-1469.83 1117.61,-1342.21 1037.66,-1245.97 1026.19,-1232.16 1012.41,-1217.47 1001.32,-1206.05"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.49" points="1003.64,-1203.41 994.14,-1198.72 998.64,-1208.31 1003.64,-1203.41"/>
+</g>
+<!-- e_16_center&#45;&gt;lac__D_c -->
+<g id="edge89" class="edge">
+<title>e_16_center&#45;&gt;lac__D_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M1224.76,-1494.27C1243.07,-1482.48 1327.04,-1428.42 1368.79,-1401.53"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.49" points="1370.75,-1404.43 1377.26,-1396.08 1366.96,-1398.55 1370.75,-1404.43"/>
+</g>
+<!-- 2pg_c -->
+<g id="node59" class="node">
+<title>2pg_c</title>
+<ellipse fill="none" stroke="black" cx="684.29" cy="-395.02" rx="18" ry="18"/>
+<text text-anchor="middle" x="684.29" y="-391.32" font-family="Times,serif" font-size="14.00">2pg_c</text>
+</g>
+<!-- 2pg_c&#45;&gt;3pg_c -->
+<g id="edge275" class="edge">
+<title>2pg_c&#45;&gt;3pg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M695.71,-409.1C718.59,-437.31 770.21,-500.96 797.63,-534.77"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.49" points="795.03,-537.12 804.05,-542.68 800.47,-532.71 795.03,-537.12"/>
+</g>
+<!-- e_17_center -->
+<g id="node60" class="node">
+<title>e_17_center</title>
+<polygon fill="none" stroke="black" points="791.89,-629.89 784.89,-629.89 784.89,-622.89 791.89,-622.89 791.89,-629.89"/>
+</g>
+<!-- 2pg_c&#45;&gt;e_17_center -->
+<g id="edge91" class="edge">
+<title>2pg_c&#45;&gt;e_17_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M691.78,-411.66C713.5,-459.94 775.72,-598.21 786.72,-622.67"/>
+</g>
+<!-- e_17_center&#45;&gt;h2o_c -->
+<g id="edge92" class="edge">
+<title>e_17_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M788.43,-630.03C788.57,-650.15 788.21,-749.64 768.44,-827.52 761.87,-853.4 751.13,-856.83 744.87,-882.78 741.41,-897.14 739.96,-913.51 739.41,-927.07"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="735.03,-927.13 739.13,-937.25 743.78,-927.37 735.03,-927.13"/>
+</g>
+<!-- e_17_center&#45;&gt;pep_c -->
+<g id="edge93" class="edge">
+<title>e_17_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M791.97,-627.1C817.9,-632.29 977.88,-664.27 1043.35,-677.36"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="1042.71,-681.69 1053.37,-679.36 1044.42,-673.11 1042.71,-681.69"/>
+</g>
+<!-- etoh_e -->
+<g id="node61" class="node">
+<title>etoh_e</title>
+<ellipse fill="none" stroke="black" cx="1316.34" cy="-1870.45" rx="18" ry="18"/>
+<text text-anchor="middle" x="1316.34" y="-1866.75" font-family="Times,serif" font-size="14.00">etoh_e</text>
+</g>
+<!-- etoh_e&#45;&gt;e_18_center -->
+<g id="edge95" class="edge">
+<title>etoh_e&#45;&gt;e_18_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1308.85,-1853.94C1281.12,-1792.84 1185.17,-1581.44 1171.08,-1550.4"/>
+</g>
+<!-- e_23_target -->
+<g id="node67" class="node">
+<title>e_23_target</title>
+<ellipse fill="black" stroke="black" cx="1426.8" cy="-2112.26" rx="1.8" ry="1.8"/>
+</g>
+<!-- etoh_e&#45;&gt;e_23_target -->
+<g id="edge102" class="edge">
+<title>etoh_e&#45;&gt;e_23_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1323.93,-1887.07C1345.04,-1933.28 1404.05,-2062.46 1421.73,-2101.16"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1418.58,-2102.69 1425.92,-2110.33 1424.95,-2099.78 1418.58,-2102.69"/>
+</g>
+<!-- e_18_center&#45;&gt;h_c -->
+<g id="edge96" class="edge">
+<title>e_18_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1166.89,-1542.84C1151.44,-1519.2 1066.34,-1387.75 1009.87,-1273.62 1000.29,-1254.26 992.82,-1230.97 987.9,-1213.23"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="991.26,-1212.26 985.29,-1203.5 984.5,-1214.07 991.26,-1212.26"/>
+</g>
+<!-- e_18_center&#45;&gt;etoh_c -->
+<g id="edge97" class="edge">
+<title>e_18_center&#45;&gt;etoh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1173.13,-1546.13C1193.45,-1543.69 1290.46,-1532.06 1339.38,-1526.19"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1340.09,-1529.63 1349.6,-1524.96 1339.25,-1522.68 1340.09,-1529.63"/>
+</g>
+<!-- e_24_target -->
+<g id="node68" class="node">
+<title>e_24_target</title>
+<ellipse fill="black" stroke="black" cx="1806.83" cy="-1672.53" rx="1.8" ry="1.8"/>
+</g>
+<!-- for_e -->
+<g id="node69" class="node">
+<title>for_e</title>
+<ellipse fill="none" stroke="black" cx="1583.93" cy="-1537.52" rx="18" ry="18"/>
+<text text-anchor="middle" x="1583.93" y="-1533.82" font-family="Times,serif" font-size="14.00">for_e</text>
+</g>
+<!-- for_e&#45;&gt;e_24_target -->
+<g id="edge103" class="edge">
+<title>for_e&#45;&gt;e_24_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1599.6,-1547.02C1642.34,-1572.9 1760.1,-1644.22 1796.19,-1666.08"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1794.7,-1669.27 1805.07,-1671.45 1798.32,-1663.28 1794.7,-1669.27"/>
+</g>
+<!-- for_e&#45;&gt;e_41_center -->
+<g id="edge125" class="edge">
+<title>for_e&#45;&gt;e_41_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1567.28,-1530.36C1507.73,-1504.76 1307.29,-1418.57 1277.86,-1405.92"/>
+</g>
+<!-- e_25_target -->
+<g id="node70" class="node">
+<title>e_25_target</title>
+<ellipse fill="black" stroke="black" cx="1605.33" cy="-1.81" rx="1.8" ry="1.8"/>
+</g>
+<!-- fru_e -->
+<g id="node71" class="node">
+<title>fru_e</title>
+<ellipse fill="none" stroke="black" cx="1470.18" cy="-219.74" rx="18" ry="18"/>
+<text text-anchor="middle" x="1470.18" y="-216.04" font-family="Times,serif" font-size="14.00">fru_e</text>
+</g>
+<!-- fru_e&#45;&gt;e_25_target -->
+<g id="edge104" class="edge">
+<title>fru_e&#45;&gt;e_25_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1479.68,-204.42C1505.59,-162.63 1577,-47.5 1598.88,-12.22"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1601.96,-13.88 1604.26,-3.54 1596.02,-10.19 1601.96,-13.88"/>
+</g>
+<!-- fru_e&#45;&gt;e_44_center -->
+<g id="edge134" class="edge">
+<title>fru_e&#45;&gt;e_44_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1460.04,-235.13C1422.52,-292.1 1292.69,-489.2 1273.62,-518.15"/>
+</g>
+<!-- e_26_target -->
+<g id="node72" class="node">
+<title>e_26_target</title>
+<ellipse fill="black" stroke="black" cx="946.12" cy="-2215.71" rx="1.8" ry="1.8"/>
+</g>
+<!-- fum_e -->
+<g id="node73" class="node">
+<title>fum_e</title>
+<ellipse fill="none" stroke="black" cx="949.94" cy="-1951.54" rx="18" ry="18"/>
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+<!-- gln__L_e&#45;&gt;e_28_target -->
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+<!-- e_29_target -->
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+<!-- glu__L_e&#45;&gt;e_29_target -->
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+<!-- glu__L_e&#45;&gt;e_55_center -->
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+<!-- e_31_target -->
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+<!-- h2o_e -->
+<g id="node82" class="node">
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+<!-- h2o_e&#45;&gt;h2o_c -->
+<g id="edge200" class="edge">
+<title>h2o_e&#45;&gt;h2o_c</title>
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+<!-- h2o_e&#45;&gt;e_31_target -->
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+<title>h2o_e&#45;&gt;e_31_target</title>
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+<!-- e_33_target -->
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+<!-- mal__L_e -->
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+<title>mal__L_e</title>
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+<!-- mal__L_e&#45;&gt;e_33_target -->
+<g id="edge112" class="edge">
+<title>mal__L_e&#45;&gt;e_33_target</title>
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+<!-- e_34_target -->
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+<title>e_34_target</title>
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+<!-- nh4_e -->
+<g id="node87" class="node">
+<title>nh4_e</title>
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+<!-- nh4_e&#45;&gt;e_34_target -->
+<g id="edge113" class="edge">
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+<!-- nh4_c -->
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+<title>nh4_c</title>
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+<!-- nh4_e&#45;&gt;nh4_c -->
+<g id="edge249" class="edge">
+<title>nh4_e&#45;&gt;nh4_c</title>
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+<!-- e_35_target -->
+<g id="node88" class="node">
+<title>e_35_target</title>
+<ellipse fill="black" stroke="black" cx="126.79" cy="-2226.11" rx="1.8" ry="1.8"/>
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+<!-- o2_e -->
+<g id="node89" class="node">
+<title>o2_e</title>
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+<!-- o2_e&#45;&gt;o2_c -->
+<g id="edge250" class="edge">
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+<!-- o2_e&#45;&gt;e_35_target -->
+<g id="edge114" class="edge">
+<title>o2_e&#45;&gt;e_35_target</title>
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+<!-- e_36_target -->
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+<title>e_36_target</title>
+<ellipse fill="black" stroke="black" cx="200.78" cy="-1664.16" rx="1.8" ry="1.8"/>
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+<!-- pi_e -->
+<g id="node91" class="node">
+<title>pi_e</title>
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+<!-- pi_e&#45;&gt;e_36_target -->
+<g id="edge115" class="edge">
+<title>pi_e&#45;&gt;e_36_target</title>
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+<!-- pi_e&#45;&gt;e_77_center -->
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+<title>pi_e&#45;&gt;e_77_center</title>
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+<!-- e_37_target -->
+<g id="node92" class="node">
+<title>e_37_target</title>
+<ellipse fill="black" stroke="black" cx="1917.12" cy="-1245.63" rx="1.8" ry="1.8"/>
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+<!-- pyr_e -->
+<g id="node93" class="node">
+<title>pyr_e</title>
+<ellipse fill="none" stroke="black" cx="1657.9" cy="-1228.74" rx="18" ry="18"/>
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+<!-- pyr_e&#45;&gt;e_37_target -->
+<g id="edge116" class="edge">
+<title>pyr_e&#45;&gt;e_37_target</title>
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+<!-- pyr_e&#45;&gt;e_83_center -->
+<g id="edge308" class="edge">
+<title>pyr_e&#45;&gt;e_83_center</title>
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+<!-- e_38_target -->
+<g id="node94" class="node">
+<title>e_38_target</title>
+<ellipse fill="black" stroke="black" cx="784.72" cy="-2052.99" rx="1.8" ry="1.8"/>
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+<!-- succ_e -->
+<g id="node95" class="node">
+<title>succ_e</title>
+<ellipse fill="none" stroke="black" cx="845.07" cy="-1785.55" rx="18" ry="18"/>
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+<!-- succ_e&#45;&gt;e_38_target -->
+<g id="edge117" class="edge">
+<title>succ_e&#45;&gt;e_38_target</title>
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+<!-- succ_e&#45;&gt;e_86_center -->
+<g id="edge313" class="edge">
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+<!-- fdp_c -->
+<g id="node96" class="node">
+<title>fdp_c</title>
+<ellipse fill="none" stroke="black" cx="840.62" cy="-486.8" rx="18" ry="18"/>
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+<!-- e_39_center -->
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+<title>e_39_center</title>
+<polygon fill="none" stroke="black" points="885.53,-271.53 878.53,-271.53 878.53,-264.53 885.53,-264.53 885.53,-271.53"/>
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+<!-- fdp_c&#45;&gt;e_39_center -->
+<g id="edge118" class="edge">
+<title>fdp_c&#45;&gt;e_39_center</title>
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+<!-- fdp_c&#45;&gt;e_40_center -->
+<g id="edge122" class="edge">
+<title>fdp_c&#45;&gt;e_40_center</title>
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+<!-- dhap_c -->
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+<title>dhap_c</title>
+<ellipse fill="none" stroke="black" cx="939.41" cy="-160.01" rx="18" ry="18"/>
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+<!-- dhap_c&#45;&gt;g3p_c -->
+<g id="edge349" class="edge">
+<title>dhap_c&#45;&gt;g3p_c</title>
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+<!-- e_39_center&#45;&gt;g3p_c -->
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+<title>e_39_center&#45;&gt;g3p_c</title>
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+<!-- e_40_center&#45;&gt;pi_c -->
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+<!-- e_40_center&#45;&gt;f6p_c -->
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+<title>e_40_center&#45;&gt;f6p_c</title>
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+<!-- for_c -->
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+<ellipse fill="none" stroke="black" cx="1470.76" cy="-1343.74" rx="18" ry="18"/>
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+<!-- for_c&#45;&gt;for_e -->
+<g id="edge129" class="edge">
+<title>for_c&#45;&gt;for_e</title>
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+<!-- e_41_center&#45;&gt;h_c -->
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+<!-- fum_c -->
+<g id="node102" class="node">
+<title>fum_c</title>
+<ellipse fill="none" stroke="black" cx="779.73" cy="-1615.73" rx="18" ry="18"/>
+<text text-anchor="middle" x="779.73" y="-1612.03" font-family="Times,serif" font-size="14.00">fum_c</text>
+</g>
+<!-- fum_c&#45;&gt;e_43_center -->
+<g id="edge131" class="edge">
+<title>fum_c&#45;&gt;e_43_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M767.97,-1629.64C750.26,-1650.57 717.76,-1688.99 707.57,-1701.04"/>
+</g>
+<!-- fum_c&#45;&gt;e_45_center -->
+<g id="edge139" class="edge">
+<title>fum_c&#45;&gt;e_45_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M782.81,-1597.81C793.3,-1536.88 827.2,-1339.81 832.18,-1310.89"/>
+</g>
+<!-- succ_c -->
+<g id="node103" class="node">
+<title>succ_c</title>
+<ellipse fill="none" stroke="black" cx="706.39" cy="-1491.69" rx="18" ry="18"/>
+<text text-anchor="middle" x="706.39" y="-1487.99" font-family="Times,serif" font-size="14.00">succ_c</text>
+</g>
+<!-- succ_c&#45;&gt;e_87_center -->
+<g id="edge318" class="edge">
+<title>succ_c&#45;&gt;e_87_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M724.36,-1493.42C763.45,-1497.2 854.24,-1505.99 873.63,-1507.86"/>
+</g>
+<!-- succ_c&#45;&gt;e_88_center -->
+<g id="edge322" class="edge">
+<title>succ_c&#45;&gt;e_88_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M702.5,-1509.47C693.24,-1551.75 670.34,-1656.29 665.78,-1677.09"/>
+</g>
+<!-- succ_c&#45;&gt;e_89_center -->
+<g id="edge327" class="edge">
+<title>succ_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M710.46,-1474.03C715.7,-1451.77 725.31,-1412.41 735.25,-1379.19 760.95,-1293.36 799.23,-1190.53 807.02,-1169.79"/>
+</g>
+<!-- e_43_center&#45;&gt;q8_c -->
+<g id="edge132" class="edge">
+<title>e_43_center&#45;&gt;q8_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M705.89,-1701.19C712.27,-1685.65 737.96,-1623.02 752.81,-1586.82"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="756.13,-1587.95 756.69,-1577.37 749.65,-1585.29 756.13,-1587.95"/>
+</g>
+<!-- e_43_center&#45;&gt;succ_c -->
+<g id="edge133" class="edge">
+<title>e_43_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M704.47,-1701.05C704.66,-1679.8 705.65,-1572.31 706.13,-1520.16"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="709.63,-1519.95 706.23,-1509.92 702.63,-1519.89 709.63,-1519.95"/>
+</g>
+<!-- e_44_center&#45;&gt;f6p_c -->
+<g id="edge137" class="edge">
+<title>e_44_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1267.62,-522.09C1244.87,-524.48 1122.02,-537.38 1066.01,-543.27"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1065.63,-539.79 1056.05,-544.31 1066.36,-546.75 1065.63,-539.79"/>
+</g>
+<!-- e_44_center&#45;&gt;pyr_c -->
+<g id="edge136" class="edge">
+<title>e_44_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1270.65,-525.24C1265.27,-555.55 1226.75,-772.43 1212.84,-850.77"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1209.35,-850.42 1211.04,-860.87 1216.24,-851.64 1209.35,-850.42"/>
+</g>
+<!-- mal__L_c -->
+<g id="node106" class="node">
+<title>mal__L_c</title>
+<ellipse fill="none" stroke="black" cx="1099.9" cy="-1247.54" rx="18" ry="18"/>
+<text text-anchor="middle" x="1099.9" y="-1243.84" font-family="Times,serif" font-size="14.00">mal__L_c</text>
+</g>
+<!-- mal__L_c&#45;&gt;e_63_center -->
+<g id="edge225" class="edge">
+<title>mal__L_c&#45;&gt;e_63_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1094.2,-1230.31C1088.25,-1212.28 1079.32,-1185.24 1076.06,-1175.37"/>
+</g>
+<!-- mal__L_c&#45;&gt;e_64_center -->
+<g id="edge230" class="edge">
+<title>mal__L_c&#45;&gt;e_64_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1112.62,-1234.51C1150.95,-1195.26 1264.01,-1079.51 1285.73,-1057.27"/>
+</g>
+<!-- mal__L_c&#45;&gt;e_65_center -->
+<g id="edge235" class="edge">
+<title>mal__L_c&#45;&gt;e_65_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1108.7,-1231.55C1124.77,-1202.72 1160.38,-1140.39 1194.83,-1090.68 1216.01,-1060.11 1245.01,-1025.77 1254.36,-1014.87"/>
+</g>
+<!-- e_45_center&#45;&gt;mal__L_c -->
+<g id="edge140" class="edge">
+<title>e_45_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M836.5,-1307.13C856.16,-1305.98 950.06,-1299.6 1023.72,-1279.4 1030.15,-1277.63 1031.44,-1276.25 1037.59,-1273.69 1049.57,-1268.71 1062.83,-1263.16 1074.03,-1258.45"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1075.39,-1261.67 1083.25,-1254.57 1072.67,-1255.22 1075.39,-1261.67"/>
+</g>
+<!-- e_46_center&#45;&gt;h_c -->
+<g id="edge143" class="edge">
+<title>e_46_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M954.99,-1589.53C955.61,-1566.56 959.27,-1439.18 966.62,-1335.58 969.63,-1293.09 974.67,-1243.98 977.93,-1213.89"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="981.43,-1214.04 979.04,-1203.72 974.47,-1213.28 981.43,-1214.04"/>
+</g>
+<!-- e_46_center&#45;&gt;fum_c -->
+<g id="edge144" class="edge">
+<title>e_46_center&#45;&gt;fum_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M951.24,-1593.64C933.04,-1595.98 851.39,-1606.5 807.64,-1612.13"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="807.11,-1608.67 797.64,-1613.42 808.01,-1615.61 807.11,-1608.67"/>
+</g>
+<!-- 6pgl_c -->
+<g id="node109" class="node">
+<title>6pgl_c</title>
+<ellipse fill="none" stroke="black" cx="1349.81" cy="-807.12" rx="18" ry="18"/>
+<text text-anchor="middle" x="1349.81" y="-803.42" font-family="Times,serif" font-size="14.00">6pgl_c</text>
+</g>
+<!-- 6pgl_c&#45;&gt;e_75_center -->
+<g id="edge272" class="edge">
+<title>6pgl_c&#45;&gt;e_75_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1332.2,-812.74C1302.98,-822.26 1242.89,-842.71 1194.07,-864.96 1170.64,-875.65 1165.81,-880.45 1142.39,-891.18 1136.33,-893.96 1135.07,-895.66 1128.52,-896.88 1115.81,-899.24 1100.36,-897.57 1093.43,-896.59"/>
+</g>
+<!-- e_47_center&#45;&gt;h_c -->
+<g id="edge148" class="edge">
+<title>e_47_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1202.24,-921.18C1190.06,-939.4 1135.06,-1020.72 1082.98,-1081.74 1056.64,-1112.6 1023.27,-1145.65 1002.04,-1166.01"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="999.36,-1163.73 994.54,-1173.16 1004.19,-1168.8 999.36,-1163.73"/>
+</g>
+<!-- e_47_center&#45;&gt;nadph_c -->
+<g id="edge149" class="edge">
+<title>e_47_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1201.11,-917.64C1193.41,-918.04 1174.74,-919 1158.46,-919.83"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1158.05,-916.35 1148.24,-920.36 1158.41,-923.34 1158.05,-916.35"/>
+</g>
+<!-- e_47_center&#45;&gt;6pgl_c -->
+<g id="edge147" class="edge">
+<title>e_47_center&#45;&gt;6pgl_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1208.48,-915.58C1218.88,-910.35 1248.7,-894.83 1271.13,-878.34 1292.37,-862.73 1314.44,-842.32 1329.78,-827.36"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1332.5,-829.6 1337.15,-820.08 1327.58,-824.62 1332.5,-829.6"/>
+</g>
+<!-- 13dpg_c -->
+<g id="node111" class="node">
+<title>13dpg_c</title>
+<ellipse fill="none" stroke="black" cx="904.29" cy="-601.16" rx="18" ry="18"/>
+<text text-anchor="middle" x="904.29" y="-597.46" font-family="Times,serif" font-size="14.00">13dpg_c</text>
+</g>
+<!-- e_48_center&#45;&gt;h_c -->
+<g id="edge154" class="edge">
+<title>e_48_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1022.72,-851.09C1018.97,-881.2 993.98,-1082 984.61,-1157.3"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="980.24,-1157 983.34,-1167.46 988.92,-1158.08 980.24,-1157"/>
+</g>
+<!-- e_48_center&#45;&gt;nadh_c -->
+<g id="edge153" class="edge">
+<title>e_48_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1025.66,-851.09C1040.34,-873.75 1116.66,-991.52 1149.89,-1042.8"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="1146.27,-1045.27 1155.38,-1051.29 1153.62,-1040.51 1146.27,-1045.27"/>
+</g>
+<!-- e_48_center&#45;&gt;13dpg_c -->
+<g id="edge155" class="edge">
+<title>e_48_center&#45;&gt;13dpg_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1021.32,-843.42C1009.45,-818.85 944.15,-683.67 916.58,-626.6"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="920.48,-624.62 912.19,-617.52 912.6,-628.43 920.48,-624.62"/>
+</g>
+<!-- e_49_center&#45;&gt;pyr_c -->
+<g id="edge158" class="edge">
+<title>e_49_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M1354.16,-592.55C1340.36,-619.56 1254.08,-788.41 1220.86,-853.43"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.4" points="1217.3,-851.94 1216.18,-862.59 1224.16,-855.44 1217.3,-851.94"/>
+</g>
+<!-- e_49_center&#45;&gt;g6p_c -->
+<g id="edge159" class="edge">
+<title>e_49_center&#45;&gt;g6p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M1352.39,-590.75C1335.12,-599.56 1260.82,-637.5 1221.06,-657.8"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.4" points="1219.13,-654.46 1211.98,-662.44 1222.63,-661.32 1219.13,-654.46"/>
+</g>
+<!-- nh4_c&#45;&gt;e_50_center -->
+<g id="edge161" class="edge">
+<title>nh4_c&#45;&gt;e_50_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M565.3,-737.47C596.38,-782.49 688.59,-916.04 704.9,-939.67"/>
+</g>
+<!-- e_50_center&#45;&gt;h_c -->
+<g id="edge165" class="edge">
+<title>e_50_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M709.18,-947.11C711.95,-952.66 717.74,-962.93 725.38,-969.14 743.8,-984.1 755.85,-974 775.68,-987.03 854.84,-1039.06 930.16,-1124.01 963.34,-1163.84"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="960.71,-1166.14 969.77,-1171.63 966.11,-1161.69 960.71,-1166.14"/>
+</g>
+<!-- e_50_center&#45;&gt;adp_c -->
+<g id="edge164" class="edge">
+<title>e_50_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M711.11,-942.23C717.07,-940.62 729.13,-937.51 739.54,-935.81 750.82,-933.96 763.34,-932.61 774.22,-931.65"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="774.76,-935.12 784.44,-930.83 774.19,-928.14 774.76,-935.12"/>
+</g>
+<!-- e_50_center&#45;&gt;pi_c -->
+<g id="edge163" class="edge">
+<title>e_50_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M711.09,-941.61C717.02,-939.15 729.03,-934.89 739.54,-935.81 765.25,-938.04 791.19,-952.49 808.98,-964.7"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="807.32,-967.83 817.49,-970.81 811.41,-962.14 807.32,-967.83"/>
+</g>
+<!-- e_50_center&#45;&gt;gln__L_c -->
+<g id="edge166" class="edge">
+<title>e_50_center&#45;&gt;gln__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M708.67,-939.67C713.24,-926.89 728.99,-882.89 739.36,-853.91"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="742.7,-854.97 742.77,-844.37 736.11,-852.61 742.7,-854.97"/>
+</g>
+<!-- e_51_center&#45;&gt;h_c -->
+<g id="edge172" class="edge">
+<title>e_51_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M644.77,-989.42C663.66,-997.48 748.12,-1034.08 813.19,-1071.78 866.97,-1102.93 926.35,-1145.27 958.07,-1168.59"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="956.14,-1171.51 966.26,-1174.63 960.3,-1165.88 956.14,-1171.51"/>
+</g>
+<!-- e_51_center&#45;&gt;adp_c -->
+<g id="edge171" class="edge">
+<title>e_51_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M644.67,-986.1C655.68,-981.12 688.59,-965.84 714.08,-949.97 719.5,-946.59 720.06,-944.54 725.63,-941.42 731.45,-938.16 733.06,-937.39 739.54,-935.81 750.64,-933.09 763.13,-931.57 774.03,-930.73"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="774.53,-934.21 784.29,-930.1 774.1,-927.22 774.53,-934.21"/>
+</g>
+<!-- e_51_center&#45;&gt;pi_c -->
+<g id="edge170" class="edge">
+<title>e_51_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M644.66,-987.48C659.52,-986.33 715.58,-982.15 761.83,-981.27 775.58,-981.01 790.85,-981.2 803.6,-981.49"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="803.54,-984.99 813.63,-981.75 803.72,-977.99 803.54,-984.99"/>
+</g>
+<!-- e_51_center&#45;&gt;gln__L_c -->
+<g id="edge173" class="edge">
+<title>e_51_center&#45;&gt;gln__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M643.36,-984.13C655.15,-966.61 706.48,-890.35 732.93,-851.04"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="736.1,-852.6 738.78,-842.35 730.3,-848.69 736.1,-852.6"/>
+</g>
+<!-- e_52_center&#45;&gt;h_c -->
+<g id="edge179" class="edge">
+<title>e_52_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M881.56,-923.1C891.25,-948.69 947.74,-1097.77 971.03,-1159.25"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="967.78,-1160.56 974.6,-1168.67 974.33,-1158.08 967.78,-1160.56"/>
+</g>
+<!-- e_52_center&#45;&gt;akg_c -->
+<g id="edge177" class="edge">
+<title>e_52_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M883.71,-920.67C894.13,-924.6 925.31,-936.78 949.34,-950.48 968.86,-961.61 973.91,-964.63 990.68,-979.58 1013.63,-1000.06 1036.66,-1026.83 1051.78,-1045.48"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1049.17,-1047.81 1058.15,-1053.43 1054.63,-1043.44 1049.17,-1047.81"/>
+</g>
+<!-- e_52_center&#45;&gt;nadph_c -->
+<g id="edge180" class="edge">
+<title>e_52_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M883.78,-919.64C898.21,-920.8 952.64,-925.03 997.54,-926.37 1033.53,-927.45 1075.01,-925.32 1101.82,-923.49"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1102.3,-926.97 1112.02,-922.76 1101.8,-919.98 1102.3,-926.97"/>
+</g>
+<!-- e_52_center&#45;&gt;nh4_c -->
+<g id="edge178" class="edge">
+<title>e_52_center&#45;&gt;nh4_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M876.48,-917.52C859.86,-909.24 789.97,-874.07 734.9,-841.2 677.43,-806.88 612.4,-762.6 578.49,-739.06"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="580.38,-736.11 570.17,-733.27 576.38,-741.86 580.38,-736.11"/>
+</g>
+<!-- e_53_center&#45;&gt;glu__L_c -->
+<g id="edge184" class="edge">
+<title>e_53_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M590.84,-849.76C605.19,-863.28 656.76,-911.65 700.68,-949.97 713.41,-961.07 727.93,-973.18 739.62,-982.81"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="737.62,-985.69 747.57,-989.33 742.06,-980.28 737.62,-985.69"/>
+</g>
+<!-- e_53_center&#45;&gt;nh4_c -->
+<g id="edge183" class="edge">
+<title>e_53_center&#45;&gt;nh4_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M586.05,-842.55C582.6,-829.19 570.22,-781.27 562.19,-750.2"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="565.54,-749.2 559.65,-740.39 558.77,-750.95 565.54,-749.2"/>
+</g>
+<!-- e_54_center&#45;&gt;glu__L_c -->
+<g id="edge190" class="edge">
+<title>e_54_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M938.98,-959.3C925.37,-967.04 876.23,-993.7 831.71,-1001.99 818.1,-1004.52 802.74,-1004.57 789.89,-1003.86"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="790.01,-1000.36 779.78,-1003.11 789.5,-1007.34 790.01,-1000.36"/>
+</g>
+<!-- e_54_center&#45;&gt;nadp_c -->
+<g id="edge189" class="edge">
+<title>e_54_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M946.38,-955.58C956.71,-951.12 986.57,-938.12 1010.94,-926.37 1043.4,-910.72 1049.41,-902.23 1083.05,-889.31 1088.58,-887.19 1094.63,-885.3 1100.46,-883.69"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1101.75,-886.97 1110.56,-881.09 1100.01,-880.19 1101.75,-886.97"/>
+</g>
+<!-- e_55_center&#45;&gt;h_c -->
+<g id="edge193" class="edge">
+<title>e_55_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M701.17,-1287.78C727.33,-1278.25 889.66,-1219.07 954.43,-1195.46"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="955.75,-1198.71 963.95,-1191.99 953.36,-1192.13 955.75,-1198.71"/>
+</g>
+<!-- e_55_center&#45;&gt;glu__L_c -->
+<g id="edge194" class="edge">
+<title>e_55_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M698.39,-1285.46C703.25,-1263.58 729.18,-1146.88 750.43,-1051.68 752.09,-1044.25 753.89,-1036.2 755.56,-1028.75"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="759.03,-1029.27 757.8,-1018.74 752.2,-1027.74 759.03,-1029.27"/>
+</g>
+<!-- 6pgc_c -->
+<g id="node121" class="node">
+<title>6pgc_c</title>
+<ellipse fill="none" stroke="black" cx="1336.79" cy="-724.73" rx="18" ry="18"/>
+<text text-anchor="middle" x="1336.79" y="-721.03" font-family="Times,serif" font-size="14.00">6pgc_c</text>
+</g>
+<!-- 6pgc_c&#45;&gt;e_56_center -->
+<g id="edge195" class="edge">
+<title>6pgc_c&#45;&gt;e_56_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1322.36,-713.53C1305.94,-700.8 1280.18,-680.82 1270.75,-673.5"/>
+</g>
+<!-- xu5p__D_c -->
+<g id="node147" class="node">
+<title>xu5p__D_c</title>
+<ellipse fill="none" stroke="black" cx="1246.76" cy="-144.93" rx="18" ry="18"/>
+<text text-anchor="middle" x="1246.76" y="-141.23" font-family="Times,serif" font-size="14.00">xu5p__D_c</text>
+</g>
+<!-- ru5p__D_c&#45;&gt;xu5p__D_c -->
+<g id="edge311" class="edge">
+<title>ru5p__D_c&#45;&gt;xu5p__D_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1299.59,-359.42C1289.64,-319.03 1265.35,-220.39 1253.49,-172.25"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1256.89,-171.39 1251.1,-162.52 1250.09,-173.06 1256.89,-171.39"/>
+</g>
+<!-- e_56_center&#45;&gt;co2_c -->
+<g id="edge198" class="edge">
+<title>e_56_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1266.95,-674.39C1265.95,-694.18 1261.19,-788.49 1258.77,-836.37"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1255.27,-836.22 1258.27,-846.39 1262.27,-836.58 1255.27,-836.22"/>
+</g>
+<!-- e_56_center&#45;&gt;nadph_c -->
+<g id="edge199" class="edge">
+<title>e_56_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1265.19,-674.24C1252.03,-698.3 1175.3,-838.53 1143.65,-896.37"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1140.54,-894.78 1138.81,-905.23 1146.68,-898.14 1140.54,-894.78"/>
+</g>
+<!-- e_56_center&#45;&gt;ru5p__D_c -->
+<g id="edge197" class="edge">
+<title>e_56_center&#45;&gt;ru5p__D_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1267.6,-666.98C1270.98,-640.02 1291.92,-473.35 1300.41,-405.72"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1303.93,-405.75 1301.7,-395.39 1296.99,-404.88 1303.93,-405.75"/>
+</g>
+<!-- e_58_center&#45;&gt;akg_c -->
+<g id="edge204" class="edge">
+<title>e_58_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M987.64,-989.78C997.98,-999.67 1027.99,-1028.36 1048.58,-1048.05"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1046.3,-1050.71 1055.95,-1055.1 1051.14,-1045.66 1046.3,-1050.71"/>
+</g>
+<!-- e_58_center&#45;&gt;co2_c -->
+<g id="edge203" class="edge">
+<title>e_58_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M987.59,-985.5C1005.28,-981.61 1084.24,-963.38 1143.74,-935.29 1179.38,-918.46 1188.77,-914.65 1221.61,-892.86 1226.2,-889.82 1230.93,-886.33 1235.39,-882.86"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1237.91,-885.33 1243.52,-876.34 1233.53,-879.87 1237.91,-885.33"/>
+</g>
+<!-- e_58_center&#45;&gt;nadph_c -->
+<g id="edge205" class="edge">
+<title>e_58_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M987.59,-984.67C1003.4,-977.64 1067.44,-949.14 1104.03,-932.86"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1105.85,-935.88 1113.57,-928.62 1103.01,-929.48 1105.85,-935.88"/>
+</g>
+<!-- glx_c -->
+<g id="node125" class="node">
+<title>glx_c</title>
+<ellipse fill="none" stroke="black" cx="605.92" cy="-1324.92" rx="18" ry="18"/>
+<text text-anchor="middle" x="605.92" y="-1321.22" font-family="Times,serif" font-size="14.00">glx_c</text>
+</g>
+<!-- glx_c&#45;&gt;e_61_center -->
+<g id="edge215" class="edge">
+<title>glx_c&#45;&gt;e_61_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M622.26,-1316.43C673.92,-1289.56 831.84,-1207.43 857.4,-1194.13"/>
+</g>
+<!-- e_59_center&#45;&gt;succ_c -->
+<g id="edge208" class="edge">
+<title>e_59_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M521.04,-1367.22C540.9,-1380.55 637.6,-1445.49 682.9,-1475.91"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="680.98,-1478.84 691.24,-1481.51 684.89,-1473.03 680.98,-1478.84"/>
+</g>
+<!-- e_59_center&#45;&gt;glx_c -->
+<g id="edge207" class="edge">
+<title>e_59_center&#45;&gt;glx_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M521.24,-1363.08C531.23,-1358.58 558.92,-1346.1 579.94,-1336.63"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="581.65,-1339.7 589.33,-1332.4 578.77,-1333.32 581.65,-1339.7"/>
+</g>
+<!-- e_60_center&#45;&gt;h_c -->
+<g id="edge213" class="edge">
+<title>e_60_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M1251.13,-1159.7C1232.62,-1161.97 1149.67,-1172.02 1081.51,-1178.29 1057.16,-1180.53 1029.43,-1182.55 1009.29,-1183.92"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.49" points="1008.97,-1180.44 999.23,-1184.6 1009.44,-1187.42 1008.97,-1180.44"/>
+</g>
+<!-- e_60_center&#45;&gt;nadh_c -->
+<g id="edge212" class="edge">
+<title>e_60_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M1251.2,-1156.19C1241.48,-1148.15 1214.67,-1125.46 1194.83,-1104.08 1190.59,-1099.5 1186.28,-1094.36 1182.32,-1089.4"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.49" points="1184.95,-1087.09 1176.05,-1081.34 1179.43,-1091.39 1184.95,-1087.09"/>
+</g>
+<!-- e_60_center&#45;&gt;pyr_c -->
+<g id="edge211" class="edge">
+<title>e_60_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M1254.31,-1155.69C1250.01,-1130.06 1223.5,-972.18 1212.56,-907.01"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.49" points="1215.99,-906.31 1210.88,-897.03 1209.09,-907.47 1215.99,-906.31"/>
+</g>
+<!-- e_61_center&#45;&gt;coa_c -->
+<g id="edge217" class="edge">
+<title>e_61_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M864.42,-1190.35C880.94,-1181.16 951.77,-1141.72 990.11,-1120.37"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="992.07,-1123.29 999.1,-1115.36 988.67,-1117.17 992.07,-1123.29"/>
+</g>
+<!-- e_61_center&#45;&gt;h_c -->
+<g id="edge219" class="edge">
+<title>e_61_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M864.64,-1192.1C877.77,-1191.39 922.66,-1188.94 952.71,-1187.3"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="953.23,-1190.78 963.02,-1186.74 952.84,-1183.79 953.23,-1190.78"/>
+</g>
+<!-- e_61_center&#45;&gt;mal__L_c -->
+<g id="edge218" class="edge">
+<title>e_61_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M864.67,-1193.17C888.15,-1198.6 1015.64,-1228.07 1072.5,-1241.21"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1071.72,-1244.62 1082.26,-1243.46 1073.3,-1237.8 1071.72,-1244.62"/>
+</g>
+<!-- e_62_center&#45;&gt;h_c -->
+<g id="edge223" class="edge">
+<title>e_62_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1091.91,-1513.72C1083.72,-1490.85 1038.46,-1364.03 1004.17,-1259.75 999.11,-1244.36 993.7,-1227.09 989.39,-1213.11"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="992.61,-1211.68 986.34,-1203.14 985.92,-1213.73 992.61,-1211.68"/>
+</g>
+<!-- e_62_center&#45;&gt;mal__L_c -->
+<g id="edge222" class="edge">
+<title>e_62_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1093.3,-1513.52C1093.94,-1487.79 1097.64,-1338.67 1099.2,-1275.65"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1102.7,-1275.7 1099.45,-1265.61 1095.7,-1275.52 1102.7,-1275.7"/>
+</g>
+<!-- e_63_center&#45;&gt;h_c -->
+<g id="edge227" class="edge">
+<title>e_63_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1071.25,-1172.13C1061.14,-1173.66 1031.56,-1178.12 1009.01,-1181.53"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1008.29,-1178.1 998.93,-1183.05 1009.34,-1185.02 1008.29,-1178.1"/>
+</g>
+<!-- e_63_center&#45;&gt;nadh_c -->
+<g id="edge226" class="edge">
+<title>e_63_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1078.37,-1167.82C1090.49,-1154.99 1129.7,-1113.41 1135.01,-1107.07 1139.63,-1101.57 1144.4,-1095.45 1148.76,-1089.67"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1151.63,-1091.68 1154.78,-1081.57 1146.01,-1087.51 1151.63,-1091.68"/>
+</g>
+<!-- e_63_center&#45;&gt;oaa_c -->
+<g id="edge228" class="edge">
+<title>e_63_center&#45;&gt;oaa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1073.28,-1168.01C1068.19,-1156.33 1050.87,-1118.63 1028.98,-1092.78 1021.52,-1083.98 1016.61,-1084.88 1008.99,-1076.22 991.57,-1056.42 975.9,-1030.69 965.5,-1011.94"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="968.54,-1010.21 960.7,-1003.09 962.39,-1013.55 968.54,-1010.21"/>
+</g>
+<!-- e_64_center&#45;&gt;nadh_c -->
+<g id="edge233" class="edge">
+<title>e_64_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1285.78,-1053.93C1272.5,-1055.34 1225.17,-1060.36 1193.95,-1063.67"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1193.24,-1060.23 1183.67,-1064.76 1193.98,-1067.19 1193.24,-1060.23"/>
+</g>
+<!-- e_64_center&#45;&gt;co2_c -->
+<g id="edge231" class="edge">
+<title>e_64_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1288.75,-1049.94C1285.49,-1030.71 1270.04,-939.35 1262.09,-892.4"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1265.5,-891.57 1260.38,-882.3 1258.6,-892.74 1265.5,-891.57"/>
+</g>
+<!-- e_64_center&#45;&gt;pyr_c -->
+<g id="edge232" class="edge">
+<title>e_64_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1287.66,-1049.91C1279.04,-1031.46 1239.91,-947.61 1219.82,-904.57"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1222.9,-902.89 1215.49,-895.31 1216.55,-905.85 1222.9,-902.89"/>
+</g>
+<!-- e_65_center&#45;&gt;co2_c -->
+<g id="edge236" class="edge">
+<title>e_65_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1257.39,-1007.72C1257.39,-992.11 1257.37,-929.85 1257.36,-892.72"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1260.86,-892.53 1257.36,-882.53 1253.86,-892.53 1260.86,-892.53"/>
+</g>
+<!-- e_65_center&#45;&gt;pyr_c -->
+<g id="edge237" class="edge">
+<title>e_65_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1256.06,-1007.81C1250.71,-993.49 1230.36,-939.09 1217.87,-905.71"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1221.05,-904.23 1214.27,-896.09 1214.49,-906.68 1221.05,-904.23"/>
+</g>
+<!-- e_65_center&#45;&gt;nadph_c -->
+<g id="edge238" class="edge">
+<title>e_65_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1253.71,-1008.75C1239.17,-998.47 1184.92,-960.11 1153.3,-937.76"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1155.22,-934.83 1145.03,-931.91 1151.17,-940.54 1155.22,-934.83"/>
+</g>
+<!-- e_66_center&#45;&gt;nad_c -->
+<g id="edge242" class="edge">
+<title>e_66_center&#45;&gt;nad_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M974.68,-1338.48C978.91,-1326.71 992.25,-1289.91 1004.17,-1259.75 1006.62,-1253.55 1006.7,-1251.73 1009.94,-1245.9 1031.54,-1207.2 1042,-1200.71 1068.11,-1164.89 1080.14,-1148.4 1093.85,-1129.88 1104.33,-1115.79"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1107.23,-1117.76 1110.4,-1107.64 1101.62,-1113.57 1107.23,-1117.76"/>
+</g>
+<!-- e_66_center&#45;&gt;h_e -->
+<g id="edge243" class="edge">
+<title>e_66_center&#45;&gt;h_e</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M974.75,-1345.94C976.21,-1349.69 978.63,-1355.88 981.17,-1362.41"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="978.01,-1363.93 984.91,-1371.97 984.53,-1361.38 978.01,-1363.93"/>
+</g>
+<!-- e_66_center&#45;&gt;q8h2_c -->
+<g id="edge244" class="edge">
+<title>e_66_center&#45;&gt;q8h2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M970.79,-1345.81C954.7,-1368.21 866.22,-1491.5 828.86,-1543.55"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="825.9,-1541.67 822.91,-1551.83 831.58,-1545.75 825.9,-1541.67"/>
+</g>
+<!-- e_67_center&#45;&gt;nadh_c -->
+<g id="edge248" class="edge">
+<title>e_67_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1294.41,-957.97C1279.3,-970.71 1219.58,-1021.03 1186.95,-1048.52"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1184.67,-1045.87 1179.28,-1054.99 1189.18,-1051.22 1184.67,-1045.87"/>
+</g>
+<!-- e_67_center&#45;&gt;nadp_c -->
+<g id="edge247" class="edge">
+<title>e_67_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1294.39,-953.02C1282.67,-946.58 1244.26,-925.75 1211.41,-910.76 1192.83,-902.27 1171.45,-893.66 1155.07,-887.3"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1156.17,-883.97 1145.58,-883.65 1153.65,-890.5 1156.17,-883.97"/>
+</g>
+<!-- e_70_center&#45;&gt;nadh_c -->
+<g id="edge255" class="edge">
+<title>e_70_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1196.1,-1000.29C1192.6,-1007.86 1184.45,-1025.46 1177.43,-1040.65"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1174.06,-1039.6 1173.03,-1050.15 1180.41,-1042.54 1174.06,-1039.6"/>
+</g>
+<!-- e_70_center&#45;&gt;accoa_c -->
+<g id="edge256" class="edge">
+<title>e_70_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1194.19,-997.89C1175.83,-1004.8 1092.88,-1036.03 1049.5,-1052.36"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1048.01,-1049.18 1039.88,-1055.98 1050.47,-1055.74 1048.01,-1049.18"/>
+</g>
+<!-- e_70_center&#45;&gt;co2_c -->
+<g id="edge254" class="edge">
+<title>e_70_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1199.43,-992.98C1205.93,-978.56 1230.78,-923.39 1245.74,-890.18"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1248.94,-891.6 1249.86,-881.05 1242.56,-888.73 1248.94,-891.6"/>
+</g>
+<!-- e_71_center&#45;&gt;h_c -->
+<g id="edge261" class="edge">
+<title>e_71_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M900.54,-788.34C901.27,-799.95 903.79,-836.25 908.27,-866.04 924.77,-975.78 958.35,-1103.77 973.44,-1158.59"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.4" points="969.73,-1159.64 976.11,-1168.25 977.15,-1157.59 969.73,-1159.64"/>
+</g>
+<!-- e_71_center&#45;&gt;adp_c -->
+<g id="edge260" class="edge">
+<title>e_71_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M897.89,-788.18C887.09,-804.19 842.73,-869.94 818.46,-905.92"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.4" points="815.16,-903.93 812.76,-914.37 821.54,-908.24 815.16,-903.93"/>
+</g>
+<!-- e_71_center&#45;&gt;fdp_c -->
+<g id="edge259" class="edge">
+<title>e_71_center&#45;&gt;fdp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M899.55,-780.83C894.05,-753.35 859.86,-582.82 846.23,-514.78"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.4" points="849.96,-513.83 844.22,-504.78 842.41,-515.34 849.96,-513.83"/>
+</g>
+<!-- e_72_center&#45;&gt;accoa_c -->
+<g id="edge265" class="edge">
+<title>e_72_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1277.86,-1120.69C1260.44,-1121.98 1182.52,-1126.69 1121.11,-1112.72 1114.61,-1111.24 1113.36,-1109.64 1107.29,-1106.88 1083.88,-1096.25 1077.91,-1093.74 1055.26,-1081.55 1052.53,-1080.08 1049.7,-1078.5 1046.9,-1076.89"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1048.61,-1073.84 1038.21,-1071.81 1045.08,-1079.88 1048.61,-1073.84"/>
+</g>
+<!-- e_72_center&#45;&gt;for_c -->
+<g id="edge264" class="edge">
+<title>e_72_center&#45;&gt;for_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1284.4,-1123.91C1303.47,-1146.41 1409.19,-1271.12 1452.38,-1322.06"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1449.85,-1324.48 1458.98,-1329.85 1455.19,-1319.96 1449.85,-1324.48"/>
+</g>
+<!-- e_74_center&#45;&gt;adp_c -->
+<g id="edge269" class="edge">
+<title>e_74_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M742.29,-694.8C748.29,-718.25 780.88,-845.58 795.41,-902.36"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.49" points="792.03,-903.28 797.9,-912.1 798.81,-901.54 792.03,-903.28"/>
+</g>
+<!-- e_74_center&#45;&gt;13dpg_c -->
+<g id="edge270" class="edge">
+<title>e_74_center&#45;&gt;13dpg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="1.49" d="M745.04,-689.01C762.71,-679.26 839.19,-637.07 879.39,-614.9"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="1.49" points="881.24,-617.87 888.3,-609.98 877.86,-611.74 881.24,-617.87"/>
+</g>
+<!-- e_75_center&#45;&gt;h_c -->
+<g id="edge274" class="edge">
+<title>e_75_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1087,-899.88C1074.63,-917.51 1023.86,-992.41 1003.27,-1062.35 993.86,-1094.33 987.77,-1132.2 984.39,-1157.48"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="980.9,-1157.12 983.1,-1167.48 987.85,-1158.01 980.9,-1157.12"/>
+</g>
+<!-- e_75_center&#45;&gt;6pgc_c -->
+<g id="edge273" class="edge">
+<title>e_75_center&#45;&gt;6pgc_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1092,-892.24C1095.99,-885.77 1104.82,-872.41 1114.75,-863.38 1177.92,-805.99 1267.9,-758.18 1311.36,-736.79"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1312.93,-739.91 1320.39,-732.39 1309.86,-733.62 1312.93,-739.91"/>
+</g>
+<!-- e_77_center&#45;&gt;h_c -->
+<g id="edge279" class="edge">
+<title>e_77_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M741.49,-1308.39C765.79,-1295.95 899.47,-1227.52 955.91,-1198.63"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="957.59,-1201.7 964.89,-1194.03 954.4,-1195.47 957.59,-1201.7"/>
+</g>
+<!-- e_77_center&#45;&gt;pi_c -->
+<g id="edge278" class="edge">
+<title>e_77_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M738.49,-1306.67C743.52,-1284.48 770.67,-1166.26 799.79,-1071.78 806.37,-1050.45 814.92,-1026.67 821.53,-1009"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="824.9,-1009.96 825.16,-999.37 818.35,-1007.49 824.9,-1009.96"/>
+</g>
+<!-- e_78_center&#45;&gt;h_c -->
+<g id="edge284" class="edge">
+<title>e_78_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1003.91,-923.44C1001.71,-948.7 989.01,-1094.58 983.56,-1157.21"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="980.04,-1157.28 982.66,-1167.54 987.01,-1157.88 980.04,-1157.28"/>
+</g>
+<!-- e_78_center&#45;&gt;pi_c -->
+<g id="edge283" class="edge">
+<title>e_78_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1000.64,-920.98C982.59,-927.55 901.16,-957.15 858.3,-972.73"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="856.99,-969.48 848.79,-976.19 859.38,-976.06 856.99,-969.48"/>
+</g>
+<!-- e_78_center&#45;&gt;oaa_c -->
+<g id="edge285" class="edge">
+<title>e_78_center&#45;&gt;oaa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1001.46,-923.29C995.54,-930.97 981.3,-949.46 969.68,-964.54"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="966.9,-962.41 963.57,-972.47 972.45,-966.68 966.9,-962.41"/>
+</g>
+<!-- e_79_center&#45;&gt;adp_c -->
+<g id="edge289" class="edge">
+<title>e_79_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M976.66,-796.4C957.33,-811.2 867.53,-879.9 824.94,-912.48"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="822.66,-909.82 816.85,-918.67 826.92,-915.37 822.66,-909.82"/>
+</g>
+<!-- e_79_center&#45;&gt;co2_c -->
+<g id="edge288" class="edge">
+<title>e_79_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M983.88,-794.46C1009.27,-800.95 1165.93,-841.01 1230.04,-857.41"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1229.3,-860.83 1239.85,-859.92 1231.03,-854.05 1229.3,-860.83"/>
+</g>
+<!-- e_79_center&#45;&gt;pep_c -->
+<g id="edge290" class="edge">
+<title>e_79_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M983.4,-789.88C994.12,-776.83 1030.85,-732.12 1053.28,-704.81"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1056.09,-706.9 1059.74,-696.95 1050.69,-702.45 1056.09,-706.9"/>
+</g>
+<!-- e_80_center&#45;&gt;h_c -->
+<g id="edge297" class="edge">
+<title>e_80_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M915.34,-862.91C916.94,-878 923.58,-938.03 932.87,-986.74 944.69,-1048.66 963.26,-1120.29 973.56,-1158.46"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="970.24,-1159.57 976.23,-1168.31 976.99,-1157.74 970.24,-1159.57"/>
+</g>
+<!-- e_80_center&#45;&gt;amp_c -->
+<g id="edge295" class="edge">
+<title>e_80_center&#45;&gt;amp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M911.4,-855.45C893.92,-836.4 815.37,-751.21 748.03,-684.35 738.78,-675.18 728.31,-665.26 719.37,-656.93"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="721.68,-654.3 711.97,-650.07 716.93,-659.44 721.68,-654.3"/>
+</g>
+<!-- e_80_center&#45;&gt;pi_c -->
+<g id="edge294" class="edge">
+<title>e_80_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M911.78,-863.1C904.58,-871.64 886.69,-893.28 873.44,-912.64 863.46,-927.2 853.28,-944.19 845.47,-957.76"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="842.38,-956.11 840.47,-966.53 848.46,-959.57 842.38,-956.11"/>
+</g>
+<!-- e_80_center&#45;&gt;pep_c -->
+<g id="edge296" class="edge">
+<title>e_80_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M917.81,-855.64C926.14,-844.84 951.32,-812.49 973.68,-786.86 999.79,-756.93 1031.51,-723.68 1051.54,-703.04"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1054.14,-705.38 1058.61,-695.78 1049.13,-700.5 1054.14,-705.38"/>
+</g>
+<!-- e_81_center&#45;&gt;coa_c -->
+<g id="edge300" class="edge">
+<title>e_81_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M763.52,-1125.01C776.22,-1124.74 819.64,-1123.68 855.41,-1121.31 901.36,-1118.28 954.59,-1112.98 986.49,-1109.62"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="987.26,-1113.06 996.83,-1108.52 986.52,-1106.09 987.26,-1113.06"/>
+</g>
+<!-- e_81_center&#45;&gt;actp_c -->
+<g id="edge301" class="edge">
+<title>e_81_center&#45;&gt;actp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M755.98,-1125.54C740.59,-1127.34 682.5,-1134.03 634.59,-1138.62 589.35,-1142.95 536.74,-1147.17 505.19,-1149.62"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="504.66,-1146.15 494.96,-1150.41 505.2,-1153.13 504.66,-1146.15"/>
+</g>
+<!-- e_82_center&#45;&gt;atp_c -->
+<g id="edge306" class="edge">
+<title>e_82_center&#45;&gt;atp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M974.79,-893.69C953.39,-892.59 844.94,-887.02 792.69,-884.33"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.4" points="792.63,-880.47 782.45,-883.8 792.24,-888.16 792.63,-880.47"/>
+</g>
+<!-- e_82_center&#45;&gt;pyr_c -->
+<g id="edge305" class="edge">
+<title>e_82_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.4" d="M982.18,-894.6C996.69,-897.33 1051.46,-906.77 1096.45,-902.71 1110.88,-901.41 1114.32,-899.78 1128.52,-896.88 1145.83,-893.35 1165.17,-888.98 1180.42,-885.43"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.4" points="1181.39,-889.16 1190.24,-883.13 1179.63,-881.66 1181.39,-889.16"/>
+</g>
+<!-- e_83_center&#45;&gt;h_c -->
+<g id="edge310" class="edge">
+<title>e_83_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1284,-1201.37C1255.62,-1199.91 1079.18,-1190.81 1009.41,-1187.21"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1009.34,-1183.71 999.17,-1186.69 1008.98,-1190.7 1009.34,-1183.71"/>
+</g>
+<!-- e_83_center&#45;&gt;pyr_c -->
+<g id="edge309" class="edge">
+<title>e_83_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1286.98,-1197.95C1279.88,-1169.31 1232.59,-978.7 1214.69,-906.53"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1218.08,-905.64 1212.27,-896.78 1211.28,-907.33 1218.08,-905.64"/>
+</g>
+<!-- xu5p__D_c&#45;&gt;e_92_center -->
+<g id="edge341" class="edge">
+<title>xu5p__D_c&#45;&gt;e_92_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1231.35,-154.43C1201.24,-173 1136.16,-213.12 1120.36,-222.86"/>
+</g>
+<!-- xu5p__D_c&#45;&gt;e_93_center -->
+<g id="edge346" class="edge">
+<title>xu5p__D_c&#45;&gt;e_93_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1235.6,-159.34C1207.29,-195.92 1133.82,-290.82 1118.64,-310.43"/>
+</g>
+<!-- e_86_center&#45;&gt;h_c -->
+<g id="edge315" class="edge">
+<title>e_86_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M905.7,-1516.98C912.5,-1487.11 957.91,-1287.52 974.78,-1213.4"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="978.25,-1213.94 977.05,-1203.41 971.42,-1212.38 978.25,-1213.94"/>
+</g>
+<!-- e_86_center&#45;&gt;succ_c -->
+<g id="edge316" class="edge">
+<title>e_86_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M901.06,-1520.18C880.69,-1517.2 783.27,-1502.94 734.44,-1495.79"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="734.92,-1492.32 724.52,-1494.34 733.91,-1499.25 734.92,-1492.32"/>
+</g>
+<!-- e_87_center&#45;&gt;h_c -->
+<g id="edge320" class="edge">
+<title>e_87_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M878.48,-1504.6C887.71,-1475.91 949.27,-1284.6 972.35,-1212.86"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="975.73,-1213.77 975.46,-1203.18 969.07,-1211.62 975.73,-1213.77"/>
+</g>
+<!-- e_87_center&#45;&gt;succ_e -->
+<g id="edge319" class="edge">
+<title>e_87_center&#45;&gt;succ_e</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M876.91,-1511.73C873.97,-1537.04 855.88,-1692.63 848.35,-1757.35"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="844.84,-1757.29 847.16,-1767.63 851.79,-1758.1 844.84,-1757.29"/>
+</g>
+<!-- e_88_center&#45;&gt;q8h2_c -->
+<g id="edge323" class="edge">
+<title>e_88_center&#45;&gt;q8h2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M668.82,-1677.69C682.18,-1667.13 727.9,-1631.06 766.01,-1601.73 773.57,-1595.91 781.87,-1589.6 789.33,-1583.96"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="791.72,-1586.54 797.6,-1577.72 787.51,-1580.95 791.72,-1586.54"/>
+</g>
+<!-- e_88_center&#45;&gt;fum_c -->
+<g id="edge324" class="edge">
+<title>e_88_center&#45;&gt;fum_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M668.55,-1678.71C681.39,-1671.43 726.12,-1646.1 754.78,-1629.86"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="756.83,-1632.72 763.81,-1624.75 753.38,-1626.63 756.83,-1632.72"/>
+</g>
+<!-- e_89_center&#45;&gt;adp_c -->
+<g id="edge329" class="edge">
+<title>e_89_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M807.9,-1162.35C806.27,-1150.91 801.38,-1115.07 799.79,-1085.18 797.43,-1040.81 799.19,-989.23 800.74,-958.05"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="804.24,-958.09 801.28,-947.92 797.25,-957.72 804.24,-958.09"/>
+</g>
+<!-- e_89_center&#45;&gt;succoa_c -->
+<g id="edge330" class="edge">
+<title>e_89_center&#45;&gt;succoa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M811.96,-1167.04C821.21,-1169.7 846.93,-1177.31 867.61,-1185.61 914.87,-1204.56 968.07,-1230.97 998.58,-1246.64"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="997.16,-1249.84 1007.65,-1251.32 1000.37,-1243.62 997.16,-1249.84"/>
+</g>
+<!-- e_89_center&#45;&gt;pi_c -->
+<g id="edge328" class="edge">
+<title>e_89_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M808.88,-1162.54C811.23,-1143.99 822.34,-1056.41 828.16,-1010.55"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="831.67,-1010.74 829.45,-1000.38 824.72,-1009.86 831.67,-1010.74"/>
+</g>
+<!-- s7p_c -->
+<g id="node152" class="node">
+<title>s7p_c</title>
+<ellipse fill="none" stroke="black" cx="1091.98" cy="-39.09" rx="18" ry="18"/>
+<text text-anchor="middle" x="1091.98" y="-35.39" font-family="Times,serif" font-size="14.00">s7p_c</text>
+</g>
+<!-- s7p_c&#45;&gt;e_90_center -->
+<g id="edge331" class="edge">
+<title>s7p_c&#45;&gt;e_90_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1088.56,-57.16C1078.9,-108.28 1051.78,-251.76 1047.19,-276.04"/>
+</g>
+<!-- e_90_center&#45;&gt;f6p_c -->
+<g id="edge334" class="edge">
+<title>e_90_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1046.11,-283.2C1043.92,-302.56 1033.87,-395.18 1033.61,-471.22 1033.55,-486.7 1034.52,-503.95 1035.58,-518"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1032.1,-518.35 1036.39,-528.03 1039.07,-517.79 1032.1,-518.35"/>
+</g>
+<!-- e_90_center&#45;&gt;e4p_c -->
+<g id="edge333" class="edge">
+<title>e_90_center&#45;&gt;e4p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1046.66,-283.22C1047.34,-302.72 1050.56,-395.32 1052.22,-442.92"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1048.73,-443.29 1052.57,-453.16 1055.72,-443.05 1048.73,-443.29"/>
+</g>
+<!-- e_91_center&#45;&gt;nad_c -->
+<g id="edge338" class="edge">
+<title>e_91_center&#45;&gt;nad_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1116.48,-1137.76C1116.88,-1134.01 1117.53,-1127.92 1118.22,-1121.42"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1121.74,-1121.47 1119.32,-1111.16 1114.78,-1120.73 1121.74,-1121.47"/>
+</g>
+<!-- e_91_center&#45;&gt;h_c -->
+<g id="edge339" class="edge">
+<title>e_91_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1112.46,-1142.74C1097.87,-1147.52 1042.41,-1165.67 1008.38,-1176.81"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1006.99,-1173.58 998.58,-1180.02 1009.17,-1180.23 1006.99,-1173.58"/>
+</g>
+<!-- e_91_center&#45;&gt;nadph_c -->
+<g id="edge340" class="edge">
+<title>e_91_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1114.24,-1137.64C1110.61,-1129.52 1102.72,-1110.19 1101.65,-1092.99 1098.43,-1041.56 1112.09,-982.46 1121.57,-948.73"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1125.05,-949.29 1124.47,-938.71 1118.33,-947.34 1125.05,-949.29"/>
+</g>
+<!-- e_92_center&#45;&gt;g3p_c -->
+<g id="edge344" class="edge">
+<title>e_92_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1115.1,-228.71C1104.04,-251.98 1043.5,-379.3 1017.33,-434.34"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1014.14,-432.9 1013.01,-443.43 1020.46,-435.91 1014.14,-432.9"/>
+</g>
+<!-- e_92_center&#45;&gt;s7p_c -->
+<g id="edge343" class="edge">
+<title>e_92_center&#45;&gt;s7p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1116.38,-221.48C1113.85,-202.61 1101.89,-113.21 1095.71,-66.96"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1099.17,-66.44 1094.37,-56.99 1092.23,-67.37 1099.17,-66.44"/>
+</g>
+<!-- e_93_center&#45;&gt;f6p_c -->
+<g id="edge348" class="edge">
+<title>e_93_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1115.19,-317.88C1111.76,-336.83 1095.47,-421.42 1067,-485.23 1061.78,-496.94 1055.74,-509.78 1050.55,-520.65"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1047.24,-519.46 1046.06,-529.99 1053.55,-522.49 1047.24,-519.46"/>
+</g>
+<!-- e_93_center&#45;&gt;g3p_c -->
+<g id="edge347" class="edge">
+<title>e_93_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1113.14,-317.61C1100.81,-333.85 1049.81,-401.03 1022.59,-436.9"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1019.47,-435.21 1016.21,-445.29 1025.05,-439.44 1019.47,-435.21"/>
+</g>
+</g>
+</svg>
\ No newline at end of file
diff --git a/main/_images/dec6276183962256e742330421b2a44e56185827fc963f98fbd9ba25aef73f96.svg b/main/_images/dec6276183962256e742330421b2a44e56185827fc963f98fbd9ba25aef73f96.svg
new file mode 100644
index 00000000..d076da63
--- /dev/null
+++ b/main/_images/dec6276183962256e742330421b2a44e56185827fc963f98fbd9ba25aef73f96.svg
@@ -0,0 +1,137 @@
+<?xml version="1.0" encoding="UTF-8" standalone="no"?>
+<!DOCTYPE svg PUBLIC "-//W3C//DTD SVG 1.1//EN"
+ "http://www.w3.org/Graphics/SVG/1.1/DTD/svg11.dtd">
+<!-- Generated by graphviz version 2.43.0 (0)
+ -->
+<!-- Title: %3 Pages: 1 -->
+<svg width="44pt" height="699pt"
+ viewBox="0.00 0.00 44.00 699.20" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
+<g id="graph0" class="graph" transform="scale(1 1) rotate(0) translate(4 695.2)">
+<title>%3</title>
+<polygon fill="white" stroke="transparent" points="-4,4 -4,-695.2 40,-695.2 40,4 -4,4"/>
+<!-- 3066 -->
+<g id="node1" class="node">
+<title>3066</title>
+<ellipse fill="none" stroke="black" cx="18" cy="-201.6" rx="18" ry="18"/>
+<text text-anchor="middle" x="18" y="-197.9" font-family="Times,serif" font-size="14.00">3066</text>
+</g>
+<!-- 1511 -->
+<g id="node2" class="node">
+<title>1511</title>
+<ellipse fill="none" stroke="black" cx="18" cy="-129.6" rx="18" ry="18"/>
+<text text-anchor="middle" x="18" y="-125.9" font-family="Times,serif" font-size="14.00">1511</text>
+</g>
+<!-- 3066&#45;&gt;1511 -->
+<g id="edge1" class="edge">
+<title>3066&#45;&gt;1511</title>
+<path fill="none" stroke="black" d="M18,-183.3C18,-175.58 18,-166.31 18,-157.71"/>
+<polygon fill="black" stroke="black" points="21.5,-157.7 18,-147.7 14.5,-157.7 21.5,-157.7"/>
+</g>
+<!-- 3629 -->
+<g id="node9" class="node">
+<title>3629</title>
+<ellipse fill="none" stroke="black" cx="18" cy="-57.6" rx="18" ry="18"/>
+<text text-anchor="middle" x="18" y="-53.9" font-family="Times,serif" font-size="14.00">3629</text>
+</g>
+<!-- 1511&#45;&gt;3629 -->
+<g id="edge8" class="edge">
+<title>1511&#45;&gt;3629</title>
+<path fill="none" stroke="black" d="M18,-111.3C18,-103.58 18,-94.31 18,-85.71"/>
+<polygon fill="black" stroke="black" points="21.5,-85.7 18,-75.7 14.5,-85.7 21.5,-85.7"/>
+</g>
+<!-- 32 -->
+<g id="node3" class="node">
+<title>32</title>
+<ellipse fill="none" stroke="black" cx="18" cy="-417.6" rx="18" ry="18"/>
+<text text-anchor="middle" x="18" y="-413.9" font-family="Times,serif" font-size="14.00">32</text>
+</g>
+<!-- 676 -->
+<g id="node4" class="node">
+<title>676</title>
+<ellipse fill="none" stroke="black" cx="18" cy="-345.6" rx="18" ry="18"/>
+<text text-anchor="middle" x="18" y="-341.9" font-family="Times,serif" font-size="14.00">676</text>
+</g>
+<!-- 32&#45;&gt;676 -->
+<g id="edge2" class="edge">
+<title>32&#45;&gt;676</title>
+<path fill="none" stroke="black" d="M18,-399.3C18,-391.58 18,-382.31 18,-373.71"/>
+<polygon fill="black" stroke="black" points="21.5,-373.7 18,-363.7 14.5,-373.7 21.5,-373.7"/>
+</g>
+<!-- 1125 -->
+<g id="node5" class="node">
+<title>1125</title>
+<ellipse fill="none" stroke="black" cx="18" cy="-273.6" rx="18" ry="18"/>
+<text text-anchor="middle" x="18" y="-269.9" font-family="Times,serif" font-size="14.00">1125</text>
+</g>
+<!-- 676&#45;&gt;1125 -->
+<g id="edge3" class="edge">
+<title>676&#45;&gt;1125</title>
+<path fill="none" stroke="black" d="M18,-327.3C18,-319.58 18,-310.31 18,-301.71"/>
+<polygon fill="black" stroke="black" points="21.5,-301.7 18,-291.7 14.5,-301.7 21.5,-301.7"/>
+</g>
+<!-- 1125&#45;&gt;3066 -->
+<g id="edge7" class="edge">
+<title>1125&#45;&gt;3066</title>
+<path fill="none" stroke="black" d="M18,-255.3C18,-247.58 18,-238.31 18,-229.71"/>
+<polygon fill="black" stroke="black" points="21.5,-229.7 18,-219.7 14.5,-229.7 21.5,-229.7"/>
+</g>
+<!-- 3439 -->
+<g id="node6" class="node">
+<title>3439</title>
+<ellipse fill="none" stroke="black" cx="18" cy="-633.6" rx="18" ry="18"/>
+<text text-anchor="middle" x="18" y="-629.9" font-family="Times,serif" font-size="14.00">3439</text>
+</g>
+<!-- 125 -->
+<g id="node7" class="node">
+<title>125</title>
+<ellipse fill="none" stroke="black" cx="18" cy="-561.6" rx="18" ry="18"/>
+<text text-anchor="middle" x="18" y="-557.9" font-family="Times,serif" font-size="14.00">125</text>
+</g>
+<!-- 3439&#45;&gt;125 -->
+<g id="edge4" class="edge">
+<title>3439&#45;&gt;125</title>
+<path fill="none" stroke="black" d="M18,-615.3C18,-607.58 18,-598.31 18,-589.71"/>
+<polygon fill="black" stroke="black" points="21.5,-589.7 18,-579.7 14.5,-589.7 21.5,-589.7"/>
+</g>
+<!-- 38 -->
+<g id="node8" class="node">
+<title>38</title>
+<ellipse fill="none" stroke="black" cx="18" cy="-489.6" rx="18" ry="18"/>
+<text text-anchor="middle" x="18" y="-485.9" font-family="Times,serif" font-size="14.00">38</text>
+</g>
+<!-- 125&#45;&gt;38 -->
+<g id="edge6" class="edge">
+<title>125&#45;&gt;38</title>
+<path fill="none" stroke="black" d="M18,-543.3C18,-535.58 18,-526.31 18,-517.71"/>
+<polygon fill="black" stroke="black" points="21.5,-517.7 18,-507.7 14.5,-517.7 21.5,-517.7"/>
+</g>
+<!-- 38&#45;&gt;32 -->
+<g id="edge5" class="edge">
+<title>38&#45;&gt;32</title>
+<path fill="none" stroke="black" d="M18,-471.3C18,-463.58 18,-454.31 18,-445.71"/>
+<polygon fill="black" stroke="black" points="21.5,-445.7 18,-435.7 14.5,-445.7 21.5,-445.7"/>
+</g>
+<!-- e_9_target -->
+<g id="node11" class="node">
+<title>e_9_target</title>
+<ellipse fill="black" stroke="black" cx="18" cy="-1.8" rx="1.8" ry="1.8"/>
+</g>
+<!-- 3629&#45;&gt;e_9_target -->
+<g id="edge10" class="edge">
+<title>3629&#45;&gt;e_9_target</title>
+<path fill="none" stroke="black" d="M18,-39.58C18,-31.17 18,-21.28 18,-13.87"/>
+<polygon fill="black" stroke="black" points="21.5,-13.73 18,-3.73 14.5,-13.73 21.5,-13.73"/>
+</g>
+<!-- e_8_source -->
+<g id="node10" class="node">
+<title>e_8_source</title>
+<ellipse fill="black" stroke="black" cx="18" cy="-689.4" rx="1.8" ry="1.8"/>
+</g>
+<!-- e_8_source&#45;&gt;3439 -->
+<g id="edge9" class="edge">
+<title>e_8_source&#45;&gt;3439</title>
+<path fill="none" stroke="black" d="M18,-687.47C18,-684.24 18,-673.15 18,-661.95"/>
+<polygon fill="black" stroke="black" points="21.5,-661.86 18,-651.86 14.5,-661.86 21.5,-661.86"/>
+</g>
+</g>
+</svg>
\ No newline at end of file
diff --git a/main/_images/eb3415394c9f08fabfe60fdc383035155cbbd36db6b706e0265150618fe18179.svg b/main/_images/eb3415394c9f08fabfe60fdc383035155cbbd36db6b706e0265150618fe18179.svg
new file mode 100644
index 00000000..84924a89
--- /dev/null
+++ b/main/_images/eb3415394c9f08fabfe60fdc383035155cbbd36db6b706e0265150618fe18179.svg
@@ -0,0 +1,2802 @@
+<?xml version="1.0" encoding="UTF-8" standalone="no"?>
+<!DOCTYPE svg PUBLIC "-//W3C//DTD SVG 1.1//EN"
+ "http://www.w3.org/Graphics/SVG/1.1/DTD/svg11.dtd">
+<!-- Generated by graphviz version 2.43.0 (0)
+ -->
+<!-- Title: %3 Pages: 1 -->
+<svg width="2099pt" height="2511pt"
+ viewBox="0.00 0.00 2099.00 2511.00" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
+<g id="graph0" class="graph" transform="scale(1 1) rotate(0) translate(4 2507)">
+<title>%3</title>
+<polygon fill="white" stroke="transparent" points="-4,4 -4,-2507 2095,-2507 2095,4 -4,4"/>
+<!-- acald_c -->
+<g id="node1" class="node">
+<title>acald_c</title>
+<ellipse fill="none" stroke="black" cx="1463.73" cy="-1375.02" rx="18" ry="18"/>
+<text text-anchor="middle" x="1463.73" y="-1371.32" font-family="Times,serif" font-size="14.00">acald_c</text>
+</g>
+<!-- e_0_center -->
+<g id="node7" class="node">
+<title>e_0_center</title>
+<polygon fill="none" stroke="black" points="1109.89,-1309.27 1102.89,-1309.27 1102.89,-1302.27 1109.89,-1302.27 1109.89,-1309.27"/>
+</g>
+<!-- acald_c&#45;&gt;e_0_center -->
+<g id="edge1" class="edge">
+<title>acald_c&#45;&gt;e_0_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1446.01,-1371.58C1378.97,-1358.59 1143.04,-1312.87 1110.19,-1306.51"/>
+</g>
+<!-- coa_c -->
+<g id="node2" class="node">
+<title>coa_c</title>
+<ellipse fill="none" stroke="black" cx="853.92" cy="-1209.28" rx="18" ry="18"/>
+<text text-anchor="middle" x="853.92" y="-1205.58" font-family="Times,serif" font-size="14.00">coa_c</text>
+</g>
+<!-- coa_c&#45;&gt;e_0_center -->
+<g id="edge2" class="edge">
+<title>coa_c&#45;&gt;e_0_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M870.88,-1216.47C896.39,-1227.22 946.2,-1247.96 989.06,-1264.25 1033.49,-1281.14 1088.21,-1299.66 1102.71,-1304.54"/>
+</g>
+<!-- e_7_center -->
+<g id="node28" class="node">
+<title>e_7_center</title>
+<polygon fill="none" stroke="black" points="1089.98,-1225.34 1082.98,-1225.34 1082.98,-1218.34 1089.98,-1218.34 1089.98,-1225.34"/>
+</g>
+<!-- coa_c&#45;&gt;e_7_center -->
+<g id="edge25" class="edge">
+<title>coa_c&#45;&gt;e_7_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M872.05,-1210.31C892.15,-1211.47 925.53,-1213.42 954.28,-1215.22 995.23,-1217.78 1005.4,-1219.65 1046.4,-1221.28 1059.75,-1221.81 1075.62,-1221.86 1082.72,-1221.85"/>
+</g>
+<!-- e_70_center -->
+<g id="node135" class="node">
+<title>e_70_center</title>
+<polygon fill="none" stroke="black" points="962.56,-1086.92 955.56,-1086.92 955.56,-1079.92 962.56,-1079.92 962.56,-1086.92"/>
+</g>
+<!-- coa_c&#45;&gt;e_70_center -->
+<g id="edge251" class="edge">
+<title>coa_c&#45;&gt;e_70_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.67" d="M865.57,-1195.33C889.31,-1166.91 942.18,-1103.62 955.81,-1087.31"/>
+</g>
+<!-- e_72_center -->
+<g id="node137" class="node">
+<title>e_72_center</title>
+<polygon fill="none" stroke="black" points="618.84,-1227.66 611.84,-1227.66 611.84,-1220.66 618.84,-1220.66 618.84,-1227.66"/>
+</g>
+<!-- coa_c&#45;&gt;e_72_center -->
+<g id="edge262" class="edge">
+<title>coa_c&#45;&gt;e_72_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M835.97,-1211.33C802.79,-1215.02 729.6,-1222.62 667.67,-1225.28 649.33,-1226.07 627.35,-1224.92 618.9,-1224.4"/>
+</g>
+<!-- e_89_center -->
+<g id="node151" class="node">
+<title>e_89_center</title>
+<polygon fill="none" stroke="black" points="747.48,-1303.97 740.48,-1303.97 740.48,-1296.97 747.48,-1296.97 747.48,-1303.97"/>
+</g>
+<!-- coa_c&#45;&gt;e_89_center -->
+<g id="edge326" class="edge">
+<title>coa_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.74" d="M839.99,-1220.82C814.57,-1241.91 761.94,-1285.57 747.64,-1297.44"/>
+</g>
+<!-- nad_c -->
+<g id="node3" class="node">
+<title>nad_c</title>
+<ellipse fill="none" stroke="black" cx="1095.67" cy="-1181.36" rx="18" ry="18"/>
+<text text-anchor="middle" x="1095.67" y="-1177.66" font-family="Times,serif" font-size="14.00">nad_c</text>
+</g>
+<!-- nad_c&#45;&gt;e_0_center -->
+<g id="edge3" class="edge">
+<title>nad_c&#45;&gt;e_0_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1097.23,-1199.45C1099.81,-1229.37 1104.8,-1287.35 1106.08,-1302.22"/>
+</g>
+<!-- nad_c&#45;&gt;e_7_center -->
+<g id="edge26" class="edge">
+<title>nad_c&#45;&gt;e_7_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M1091.61,-1199.23C1090,-1206.35 1088.29,-1213.86 1087.31,-1218.18"/>
+</g>
+<!-- e_9_center -->
+<g id="node32" class="node">
+<title>e_9_center</title>
+<polygon fill="none" stroke="black" points="1221.67,-1365.96 1214.67,-1365.96 1214.67,-1358.96 1221.67,-1358.96 1221.67,-1365.96"/>
+</g>
+<!-- nad_c&#45;&gt;e_9_center -->
+<g id="edge36" class="edge">
+<title>nad_c&#45;&gt;e_9_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1105.91,-1196.49C1132.36,-1235.59 1201.9,-1338.4 1215.75,-1358.88"/>
+</g>
+<!-- e_12_center -->
+<g id="node49" class="node">
+<title>e_12_center</title>
+<polygon fill="none" stroke="black" points="953.46,-947.32 946.46,-947.32 946.46,-940.32 953.46,-940.32 953.46,-947.32"/>
+</g>
+<!-- nad_c&#45;&gt;e_12_center -->
+<g id="edge66" class="edge">
+<title>nad_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M1086.01,-1165.84C1076.4,-1150.4 1061.25,-1126.01 1048.23,-1104.84 1009.45,-1041.8 962.55,-964.57 952.09,-947.34"/>
+</g>
+<!-- e_48_center -->
+<g id="node112" class="node">
+<title>e_48_center</title>
+<polygon fill="none" stroke="black" points="978.22,-955.8 971.22,-955.8 971.22,-948.8 978.22,-948.8 978.22,-955.8"/>
+</g>
+<!-- nad_c&#45;&gt;e_48_center -->
+<g id="edge151" class="edge">
+<title>nad_c&#45;&gt;e_48_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.51" d="M1085.57,-1166.1C1075.63,-1150.85 1060.24,-1126.6 1048.23,-1104.84 1016.42,-1047.18 984,-973.64 976.39,-956.15"/>
+</g>
+<!-- e_60_center -->
+<g id="node127" class="node">
+<title>e_60_center</title>
+<polygon fill="none" stroke="black" points="999.26,-1261.05 992.26,-1261.05 992.26,-1254.05 999.26,-1254.05 999.26,-1261.05"/>
+</g>
+<!-- nad_c&#45;&gt;e_60_center -->
+<g id="edge210" class="edge">
+<title>nad_c&#45;&gt;e_60_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1083.11,-1194.66C1076.58,-1201.27 1068.3,-1209.19 1060.28,-1215.58 1038.54,-1232.89 1009.53,-1249.78 999.42,-1255.5"/>
+</g>
+<!-- e_63_center -->
+<g id="node130" class="node">
+<title>e_63_center</title>
+<polygon fill="none" stroke="black" points="951.08,-1225.42 944.08,-1225.42 944.08,-1218.42 951.08,-1218.42 951.08,-1225.42"/>
+</g>
+<!-- nad_c&#45;&gt;e_63_center -->
+<g id="edge225" class="edge">
+<title>nad_c&#45;&gt;e_63_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M1077.29,-1180.04C1067.99,-1179.77 1056.56,-1180.06 1046.51,-1182.08 1007.3,-1189.98 963.83,-1212.91 951.2,-1219.88"/>
+</g>
+<!-- e_64_center -->
+<g id="node131" class="node">
+<title>e_64_center</title>
+<polygon fill="none" stroke="black" points="1000.43,-1109.55 993.43,-1109.55 993.43,-1102.55 1000.43,-1102.55 1000.43,-1109.55"/>
+</g>
+<!-- nad_c&#45;&gt;e_64_center -->
+<g id="edge230" class="edge">
+<title>nad_c&#45;&gt;e_64_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1081.1,-1170.25C1057.93,-1152.57 1013.94,-1119.02 1000.76,-1108.97"/>
+</g>
+<!-- e_67_center -->
+<g id="node134" class="node">
+<title>e_67_center</title>
+<polygon fill="none" stroke="black" points="1281.96,-1138.68 1274.96,-1138.68 1274.96,-1131.68 1281.96,-1131.68 1281.96,-1138.68"/>
+</g>
+<!-- nad_c&#45;&gt;e_67_center -->
+<g id="edge246" class="edge">
+<title>nad_c&#45;&gt;e_67_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1113.2,-1176.93C1154.12,-1166.59 1254.07,-1141.34 1274.7,-1136.13"/>
+</g>
+<!-- nad_c&#45;&gt;e_70_center -->
+<g id="edge253" class="edge">
+<title>nad_c&#45;&gt;e_70_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.67" d="M1079.71,-1172.19C1058.52,-1159.75 1020.28,-1136.37 990.23,-1112.75 979.48,-1104.31 968.08,-1092.85 962.52,-1087.07"/>
+</g>
+<!-- accoa_c -->
+<g id="node4" class="node">
+<title>accoa_c</title>
+<ellipse fill="none" stroke="black" cx="810.37" cy="-1159.91" rx="18" ry="18"/>
+<text text-anchor="middle" x="810.37" y="-1156.21" font-family="Times,serif" font-size="14.00">accoa_c</text>
+</g>
+<!-- accoa_c&#45;&gt;e_12_center -->
+<g id="edge63" class="edge">
+<title>accoa_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M820.18,-1144.72C848.98,-1100.14 932.17,-971.36 947.51,-947.61"/>
+</g>
+<!-- e_14_center -->
+<g id="node51" class="node">
+<title>e_14_center</title>
+<polygon fill="none" stroke="black" points="664.47,-1222.08 657.47,-1222.08 657.47,-1215.08 664.47,-1215.08 664.47,-1222.08"/>
+</g>
+<!-- accoa_c&#45;&gt;e_14_center -->
+<g id="edge75" class="edge">
+<title>accoa_c&#45;&gt;e_14_center</title>
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+</g>
+<!-- e_61_center -->
+<g id="node128" class="node">
+<title>e_61_center</title>
+<polygon fill="none" stroke="black" points="754.54,-1348.04 747.54,-1348.04 747.54,-1341.04 754.54,-1341.04 754.54,-1348.04"/>
+</g>
+<!-- accoa_c&#45;&gt;e_61_center -->
+<g id="edge214" class="edge">
+<title>accoa_c&#45;&gt;e_61_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M807.24,-1177.9C803.81,-1196.4 797.73,-1225.93 789.86,-1250.73 778.45,-1286.69 758.99,-1328.08 752.91,-1340.7"/>
+</g>
+<!-- e_81_center -->
+<g id="node144" class="node">
+<title>e_81_center</title>
+<polygon fill="none" stroke="black" points="595.3,-1133.39 588.3,-1133.39 588.3,-1126.39 595.3,-1126.39 595.3,-1133.39"/>
+</g>
+<!-- accoa_c&#45;&gt;e_81_center -->
+<g id="edge298" class="edge">
+<title>accoa_c&#45;&gt;e_81_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M792.1,-1158.48C775.18,-1157.08 749.32,-1154.72 726.96,-1151.83 674.62,-1145.05 611.41,-1133.53 595.55,-1130.59"/>
+</g>
+<!-- nadh_c -->
+<g id="node5" class="node">
+<title>nadh_c</title>
+<ellipse fill="none" stroke="black" cx="1046.46" cy="-1201.68" rx="18" ry="18"/>
+<text text-anchor="middle" x="1046.46" y="-1197.98" font-family="Times,serif" font-size="14.00">nadh_c</text>
+</g>
+<!-- e_66_center -->
+<g id="node133" class="node">
+<title>e_66_center</title>
+<polygon fill="none" stroke="black" points="969.17,-1479.02 962.17,-1479.02 962.17,-1472.02 969.17,-1472.02 969.17,-1479.02"/>
+</g>
+<!-- nadh_c&#45;&gt;e_66_center -->
+<g id="edge240" class="edge">
+<title>nadh_c&#45;&gt;e_66_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1041.28,-1219.22C1024.91,-1274.71 974.88,-1444.3 966.78,-1471.75"/>
+</g>
+<!-- e_91_center -->
+<g id="node154" class="node">
+<title>e_91_center</title>
+<polygon fill="none" stroke="black" points="1119.77,-1275.95 1112.77,-1275.95 1112.77,-1268.95 1119.77,-1268.95 1119.77,-1275.95"/>
+</g>
+<!-- nadh_c&#45;&gt;e_91_center -->
+<g id="edge336" class="edge">
+<title>nadh_c&#45;&gt;e_91_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1059.26,-1214.66C1075.64,-1231.26 1103.04,-1259.03 1112.73,-1268.87"/>
+</g>
+<!-- h_c -->
+<g id="node6" class="node">
+<title>h_c</title>
+<ellipse fill="none" stroke="black" cx="911.41" cy="-1310.11" rx="18" ry="18"/>
+<text text-anchor="middle" x="911.41" y="-1306.41" font-family="Times,serif" font-size="14.00">h_c</text>
+</g>
+<!-- e_15_center -->
+<g id="node55" class="node">
+<title>e_15_center</title>
+<polygon fill="none" stroke="black" points="740.69,-1560.2 733.69,-1560.2 733.69,-1553.2 740.69,-1553.2 740.69,-1560.2"/>
+</g>
+<!-- h_c&#45;&gt;e_15_center -->
+<g id="edge83" class="edge">
+<title>h_c&#45;&gt;e_15_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M899.89,-1324.51C878.68,-1351.19 832.36,-1410.34 796.42,-1462.44 772.72,-1496.8 746.85,-1540.28 739.34,-1553.03"/>
+</g>
+<!-- e_54_center -->
+<g id="node119" class="node">
+<title>e_54_center</title>
+<polygon fill="none" stroke="black" points="1093.53,-1117 1086.53,-1117 1086.53,-1110 1093.53,-1110 1093.53,-1117"/>
+</g>
+<!-- h_c&#45;&gt;e_54_center -->
+<g id="edge185" class="edge">
+<title>h_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M923.69,-1296.6C960.1,-1256.52 1066.24,-1139.68 1086.62,-1117.25"/>
+</g>
+<!-- h_c&#45;&gt;e_66_center -->
+<g id="edge241" class="edge">
+<title>h_c&#45;&gt;e_66_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M913.63,-1328.02C915.97,-1344.85 920.22,-1370.64 926.62,-1392.38 928.5,-1398.77 929.61,-1400.16 932.32,-1406.25 943.63,-1431.61 958.58,-1461.49 963.78,-1471.8"/>
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+<!-- e_82_center -->
+<g id="node145" class="node">
+<title>e_82_center</title>
+<polygon fill="none" stroke="black" points="780.91,-1045.84 773.91,-1045.84 773.91,-1038.84 780.91,-1038.84 780.91,-1045.84"/>
+</g>
+<!-- h_c&#45;&gt;e_82_center -->
+<g id="edge303" class="edge">
+<title>h_c&#45;&gt;e_82_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.12" d="M905.12,-1292.95C897.72,-1272.85 884.98,-1238.6 873.52,-1209.37 871.08,-1203.17 870.81,-1201.46 867.85,-1195.49 837.11,-1133.53 790.92,-1062.75 779.86,-1046.02"/>
+</g>
+<!-- e_0_center&#45;&gt;accoa_c -->
+<g id="edge4" class="edge">
+<title>e_0_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1102.89,-1303.69C1089.9,-1296.01 1043.15,-1268.84 1002.46,-1250.85 975.85,-1239.08 967.5,-1240.37 940.88,-1228.62 902.9,-1211.87 860.69,-1188.78 834.84,-1174.1"/>
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+</g>
+<!-- e_0_center&#45;&gt;nadh_c -->
+<g id="edge5" class="edge">
+<title>e_0_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1104.11,-1301.81C1097.06,-1289.58 1075.21,-1251.61 1060.52,-1226.1"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1063.5,-1224.26 1055.48,-1217.34 1057.43,-1227.75 1063.5,-1224.26"/>
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+<!-- e_0_center&#45;&gt;h_c -->
+<g id="edge6" class="edge">
+<title>e_0_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1102.67,-1305.85C1082.74,-1306.29 987.81,-1308.41 939.62,-1309.49"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="939.46,-1305.99 929.54,-1309.71 939.62,-1312.99 939.46,-1305.99"/>
+</g>
+<!-- acald_e -->
+<g id="node8" class="node">
+<title>acald_e</title>
+<ellipse fill="none" stroke="black" cx="1845.44" cy="-1428.03" rx="18" ry="18"/>
+<text text-anchor="middle" x="1845.44" y="-1424.33" font-family="Times,serif" font-size="14.00">acald_e</text>
+</g>
+<!-- acald_e&#45;&gt;acald_c -->
+<g id="edge7" class="edge">
+<title>acald_e&#45;&gt;acald_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1827.54,-1425.55C1766.43,-1417.06 1565.72,-1389.18 1491.58,-1378.88"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1491.98,-1375.41 1481.59,-1377.5 1491.01,-1382.34 1491.98,-1375.41"/>
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+<!-- e_20_target -->
+<g id="node64" class="node">
+<title>e_20_target</title>
+<ellipse fill="black" stroke="black" cx="2089.18" cy="-1466.88" rx="1.8" ry="1.8"/>
+</g>
+<!-- acald_e&#45;&gt;e_20_target -->
+<g id="edge99" class="edge">
+<title>acald_e&#45;&gt;e_20_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1863.36,-1430.89C1910.67,-1438.43 2037.97,-1458.72 2077.38,-1465"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="2076.84,-1468.45 2087.26,-1466.57 2077.94,-1461.54 2076.84,-1468.45"/>
+</g>
+<!-- atp_c -->
+<g id="node9" class="node">
+<title>atp_c</title>
+<ellipse fill="none" stroke="black" cx="722.32" cy="-1049.99" rx="18" ry="18"/>
+<text text-anchor="middle" x="722.32" y="-1046.29" font-family="Times,serif" font-size="14.00">atp_c</text>
+</g>
+<!-- e_2_center -->
+<g id="node13" class="node">
+<title>e_2_center</title>
+<polygon fill="none" stroke="black" points="489.88,-1132.95 482.88,-1132.95 482.88,-1125.95 489.88,-1125.95 489.88,-1132.95"/>
+</g>
+<!-- atp_c&#45;&gt;e_2_center -->
+<g id="edge8" class="edge">
+<title>atp_c&#45;&gt;e_2_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M704.97,-1055.83C655.37,-1072.53 514.98,-1119.81 490.15,-1128.18"/>
+</g>
+<!-- e_6_center -->
+<g id="node24" class="node">
+<title>e_6_center</title>
+<polygon fill="none" stroke="black" points="528.76,-914.56 521.76,-914.56 521.76,-907.56 528.76,-907.56 528.76,-914.56"/>
+</g>
+<!-- atp_c&#45;&gt;e_6_center -->
+<g id="edge22" class="edge">
+<title>atp_c&#45;&gt;e_6_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M707.5,-1039.54C666.15,-1010.39 551.04,-929.23 528.96,-913.66"/>
+</g>
+<!-- e_10_center -->
+<g id="node34" class="node">
+<title>e_10_center</title>
+<polygon fill="none" stroke="black" points="711.89,-1184.23 704.89,-1184.23 704.89,-1177.23 711.89,-1177.23 711.89,-1184.23"/>
+</g>
+<!-- atp_c&#45;&gt;e_10_center -->
+<g id="edge40" class="edge">
+<title>atp_c&#45;&gt;e_10_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.51" d="M718.08,-1067.5C714.32,-1084.05 709.17,-1109.65 707.37,-1132.21 706.04,-1149.01 707.41,-1169.18 708.08,-1177.2"/>
+</g>
+<!-- atp_c&#45;&gt;e_12_center -->
+<g id="edge62" class="edge">
+<title>atp_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M739.54,-1044.64C770.58,-1034.68 837.55,-1011.79 890.07,-983.87 912.6,-971.89 937.25,-953.57 946.34,-946.62"/>
+</g>
+<!-- e_50_center -->
+<g id="node115" class="node">
+<title>e_50_center</title>
+<polygon fill="none" stroke="black" points="962.14,-1043.72 955.14,-1043.72 955.14,-1036.72 962.14,-1036.72 962.14,-1043.72"/>
+</g>
+<!-- atp_c&#45;&gt;e_50_center -->
+<g id="edge160" class="edge">
+<title>atp_c&#45;&gt;e_50_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.55" d="M740.46,-1050.25C752.78,-1050.3 769.45,-1050.1 784.11,-1049.04 804.61,-1047.56 809.48,-1044.65 829.97,-1043.1 879.43,-1039.35 939.87,-1039.94 955.05,-1040.16"/>
+</g>
+<!-- e_51_center -->
+<g id="node116" class="node">
+<title>e_51_center</title>
+<polygon fill="none" stroke="black" points="627.63,-1045.2 620.63,-1045.2 620.63,-1038.2 627.63,-1038.2 627.63,-1045.2"/>
+</g>
+<!-- atp_c&#45;&gt;e_51_center -->
+<g id="edge167" class="edge">
+<title>atp_c&#45;&gt;e_51_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M704.31,-1048.47C680.39,-1046.45 639.75,-1043.02 627.64,-1042"/>
+</g>
+<!-- e_71_center -->
+<g id="node136" class="node">
+<title>e_71_center</title>
+<polygon fill="none" stroke="black" points="842.37,-904.95 835.37,-904.95 835.37,-897.95 842.37,-897.95 842.37,-904.95"/>
+</g>
+<!-- atp_c&#45;&gt;e_71_center -->
+<g id="edge257" class="edge">
+<title>atp_c&#45;&gt;e_71_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.34" d="M731.83,-1034.33C742.73,-1016.77 761.49,-987.7 780.02,-964.44 799.22,-940.32 825.63,-914.23 835.21,-904.96"/>
+</g>
+<!-- e_74_center -->
+<g id="node138" class="node">
+<title>e_74_center</title>
+<polygon fill="none" stroke="black" points="668.33,-810.83 661.33,-810.83 661.33,-803.83 668.33,-803.83 668.33,-810.83"/>
+</g>
+<!-- atp_c&#45;&gt;e_74_center -->
+<g id="edge268" class="edge">
+<title>atp_c&#45;&gt;e_74_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.96" d="M711.7,-1035.26C706.39,-1027.04 700.48,-1016.37 697.5,-1005.89 675.67,-928.93 666.75,-830.77 665.11,-810.93"/>
+</g>
+<!-- e_79_center -->
+<g id="node142" class="node">
+<title>e_79_center</title>
+<polygon fill="none" stroke="black" points="875.97,-895.95 868.97,-895.95 868.97,-888.95 875.97,-888.95 875.97,-895.95"/>
+</g>
+<!-- atp_c&#45;&gt;e_79_center -->
+<g id="edge286" class="edge">
+<title>atp_c&#45;&gt;e_79_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M730.98,-1034.08C741.26,-1016.05 759.6,-986.3 780.02,-964.44 810.29,-932.03 856.05,-902.61 868.96,-894.6"/>
+</g>
+<!-- e_80_center -->
+<g id="node143" class="node">
+<title>e_80_center</title>
+<polygon fill="none" stroke="black" points="668.01,-1026.38 661.01,-1026.38 661.01,-1019.38 668.01,-1019.38 668.01,-1026.38"/>
+</g>
+<!-- atp_c&#45;&gt;e_80_center -->
+<g id="edge291" class="edge">
+<title>atp_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M705.91,-1042.29C692.82,-1036.16 675.51,-1028.04 668.11,-1024.57"/>
+</g>
+<!-- atp_c&#45;&gt;e_89_center -->
+<g id="edge325" class="edge">
+<title>atp_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.74" d="M728.97,-1066.98C735,-1083.39 743.41,-1109.08 746.57,-1132.24 755.5,-1197.65 746.65,-1278.68 744.45,-1296.77"/>
+</g>
+<!-- ac_c -->
+<g id="node10" class="node">
+<title>ac_c</title>
+<ellipse fill="none" stroke="black" cx="421.51" cy="-1397.64" rx="18" ry="18"/>
+<text text-anchor="middle" x="421.51" y="-1393.94" font-family="Times,serif" font-size="14.00">ac_c</text>
+</g>
+<!-- ac_c&#45;&gt;e_2_center -->
+<g id="edge9" class="edge">
+<title>ac_c&#45;&gt;e_2_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M425.77,-1380.05C439.02,-1325.27 479.02,-1159.89 485.49,-1133.12"/>
+</g>
+<!-- actp_c -->
+<g id="node11" class="node">
+<title>actp_c</title>
+<ellipse fill="none" stroke="black" cx="325.97" cy="-1083.54" rx="18" ry="18"/>
+<text text-anchor="middle" x="325.97" y="-1079.84" font-family="Times,serif" font-size="14.00">actp_c</text>
+</g>
+<!-- adp_c -->
+<g id="node12" class="node">
+<title>adp_c</title>
+<ellipse fill="none" stroke="black" cx="717.1" cy="-1005.95" rx="18" ry="18"/>
+<text text-anchor="middle" x="717.1" y="-1002.25" font-family="Times,serif" font-size="14.00">adp_c</text>
+</g>
+<!-- e_11_center -->
+<g id="node35" class="node">
+<title>e_11_center</title>
+<polygon fill="none" stroke="black" points="786.66,-1247.53 779.66,-1247.53 779.66,-1240.53 786.66,-1240.53 786.66,-1247.53"/>
+</g>
+<!-- adp_c&#45;&gt;e_11_center -->
+<g id="edge47" class="edge">
+<title>adp_c&#45;&gt;e_11_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M727.54,-1020.75C732.79,-1029 738.71,-1039.69 741.92,-1050.11 747.83,-1069.36 777.39,-1215.44 782.43,-1240.41"/>
+</g>
+<!-- adp_c&#45;&gt;e_82_center -->
+<g id="edge304" class="edge">
+<title>adp_c&#45;&gt;e_82_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.12" d="M732.63,-1015.32C746.32,-1023.58 765.3,-1035.03 773.44,-1039.95"/>
+</g>
+<!-- e_2_center&#45;&gt;actp_c -->
+<g id="edge10" class="edge">
+<title>e_2_center&#45;&gt;actp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M482.73,-1128.4C465.69,-1123.53 393.2,-1102.78 353.04,-1091.29"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="353.92,-1087.9 343.34,-1088.52 351.99,-1094.63 353.92,-1087.9"/>
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+<!-- e_2_center&#45;&gt;adp_c -->
+<g id="edge11" class="edge">
+<title>e_2_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M490,-1127.51C512.88,-1115.26 638.04,-1048.27 692.16,-1019.3"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="693.94,-1022.32 701.1,-1014.51 690.63,-1016.15 693.94,-1022.32"/>
+</g>
+<!-- cit_c -->
+<g id="node14" class="node">
+<title>cit_c</title>
+<ellipse fill="none" stroke="black" cx="368.41" cy="-1238.7" rx="18" ry="18"/>
+<text text-anchor="middle" x="368.41" y="-1235" font-family="Times,serif" font-size="14.00">cit_c</text>
+</g>
+<!-- e_3_center -->
+<g id="node17" class="node">
+<title>e_3_center</title>
+<polygon fill="none" stroke="black" points="393.82,-1145.99 386.82,-1145.99 386.82,-1138.99 393.82,-1138.99 393.82,-1145.99"/>
+</g>
+<!-- cit_c&#45;&gt;e_3_center -->
+<g id="edge12" class="edge">
+<title>cit_c&#45;&gt;e_3_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M372.43,-1221.05C377.72,-1197.83 386.67,-1158.53 389.46,-1146.26"/>
+</g>
+<!-- acon_C_c -->
+<g id="node15" class="node">
+<title>acon_C_c</title>
+<ellipse fill="none" stroke="black" cx="208.35" cy="-1202.14" rx="18" ry="18"/>
+<text text-anchor="middle" x="208.35" y="-1198.44" font-family="Times,serif" font-size="14.00">acon_C_c</text>
+</g>
+<!-- e_4_center -->
+<g id="node19" class="node">
+<title>e_4_center</title>
+<polygon fill="none" stroke="black" points="453.87,-1244.9 446.87,-1244.9 446.87,-1237.9 453.87,-1237.9 453.87,-1244.9"/>
+</g>
+<!-- acon_C_c&#45;&gt;e_4_center -->
+<g id="edge15" class="edge">
+<title>acon_C_c&#45;&gt;e_4_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M226.74,-1203.12C256.67,-1204.94 317.69,-1209.54 368.53,-1219.1 399.21,-1224.87 435.2,-1236.38 446.67,-1240.16"/>
+</g>
+<!-- h2o_c -->
+<g id="node16" class="node">
+<title>h2o_c</title>
+<ellipse fill="none" stroke="black" cx="726.97" cy="-1132.23" rx="18" ry="18"/>
+<text text-anchor="middle" x="726.97" y="-1128.53" font-family="Times,serif" font-size="14.00">h2o_c</text>
+</g>
+<!-- h2o_c&#45;&gt;e_4_center -->
+<g id="edge16" class="edge">
+<title>h2o_c&#45;&gt;e_4_center</title>
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+</g>
+<!-- h2o_c&#45;&gt;e_10_center -->
+<g id="edge41" class="edge">
+<title>h2o_c&#45;&gt;e_10_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.51" d="M720.47,-1149.19C716.62,-1159.25 712.07,-1171.14 709.81,-1177.04"/>
+</g>
+<!-- h2o_c&#45;&gt;e_12_center -->
+<g id="edge58" class="edge">
+<title>h2o_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M737.77,-1117.34C744.05,-1109.12 752.35,-1098.95 760.71,-1090.78 828.84,-1024.2 926.52,-959.14 946.36,-946.16"/>
+</g>
+<!-- h2o_c&#45;&gt;e_14_center -->
+<g id="edge76" class="edge">
+<title>h2o_c&#45;&gt;e_14_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M715.78,-1146.87C700.18,-1167.28 672.83,-1203.06 663.89,-1214.76"/>
+</g>
+<!-- e_40_center -->
+<g id="node99" class="node">
+<title>e_40_center</title>
+<polygon fill="none" stroke="black" points="793.71,-837.53 786.71,-837.53 786.71,-830.53 793.71,-830.53 793.71,-837.53"/>
+</g>
+<!-- h2o_c&#45;&gt;e_40_center -->
+<g id="edge121" class="edge">
+<title>h2o_c&#45;&gt;e_40_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M730.74,-1114.46C743.29,-1055.28 783.24,-866.89 789.41,-837.81"/>
+</g>
+<!-- e_45_center -->
+<g id="node107" class="node">
+<title>e_45_center</title>
+<polygon fill="none" stroke="black" points="806.62,-1472.64 799.62,-1472.64 799.62,-1465.64 806.62,-1465.64 806.62,-1472.64"/>
+</g>
+<!-- h2o_c&#45;&gt;e_45_center -->
+<g id="edge138" class="edge">
+<title>h2o_c&#45;&gt;e_45_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M730.96,-1149.86C745.53,-1214.31 795.38,-1434.88 802.32,-1465.58"/>
+</g>
+<!-- h2o_c&#45;&gt;e_51_center -->
+<g id="edge169" class="edge">
+<title>h2o_c&#45;&gt;e_51_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M713.1,-1120.02C689.2,-1098.98 641.48,-1056.98 627.85,-1044.98"/>
+</g>
+<!-- e_52_center -->
+<g id="node117" class="node">
+<title>e_52_center</title>
+<polygon fill="none" stroke="black" points="1058.43,-1101.64 1051.43,-1101.64 1051.43,-1094.64 1058.43,-1094.64 1058.43,-1101.64"/>
+</g>
+<!-- h2o_c&#45;&gt;e_52_center -->
+<g id="edge175" class="edge">
+<title>h2o_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.57" d="M744.78,-1129.34C787.17,-1122.63 897.43,-1106 990.23,-1099.35 1013.54,-1097.68 1041.68,-1097.92 1051.42,-1098.07"/>
+</g>
+<!-- e_53_center -->
+<g id="node118" class="node">
+<title>e_53_center</title>
+<polygon fill="none" stroke="black" points="1025.69,-977.67 1018.69,-977.67 1018.69,-970.67 1025.69,-970.67 1025.69,-977.67"/>
+</g>
+<!-- h2o_c&#45;&gt;e_53_center -->
+<g id="edge181" class="edge">
+<title>h2o_c&#45;&gt;e_53_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M745.25,-1130.14C754.18,-1128.88 765.03,-1126.97 774.53,-1124.26 780.94,-1122.42 782.46,-1121.57 788.39,-1118.53 886.1,-1068.62 996.96,-991.87 1018.47,-976.79"/>
+</g>
+<!-- h2o_c&#45;&gt;e_61_center -->
+<g id="edge215" class="edge">
+<title>h2o_c&#45;&gt;e_61_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M730.42,-1150.06C735.97,-1179.74 746.66,-1241.2 750.68,-1293.77 752.03,-1311.35 751.49,-1332.45 751.19,-1340.84"/>
+</g>
+<!-- e_75_center -->
+<g id="node139" class="node">
+<title>e_75_center</title>
+<polygon fill="none" stroke="black" points="1082.37,-1040.83 1075.37,-1040.83 1075.37,-1033.83 1082.37,-1033.83 1082.37,-1040.83"/>
+</g>
+<!-- h2o_c&#45;&gt;e_75_center -->
+<g id="edge272" class="edge">
+<title>h2o_c&#45;&gt;e_75_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M745.13,-1129.67C754.03,-1128.3 764.89,-1126.43 774.53,-1124.26 838.04,-1109.91 1044.8,-1047.62 1075.14,-1038.45"/>
+</g>
+<!-- e_78_center -->
+<g id="node141" class="node">
+<title>e_78_center</title>
+<polygon fill="none" stroke="black" points="885.39,-1033.68 878.39,-1033.68 878.39,-1026.68 885.39,-1026.68 885.39,-1033.68"/>
+</g>
+<!-- h2o_c&#45;&gt;e_78_center -->
+<g id="edge282" class="edge">
+<title>h2o_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.66" d="M737.73,-1117.3C744,-1109.07 752.31,-1098.91 760.71,-1090.78 782.92,-1069.31 789.23,-1064.03 816.08,-1048.74 837.74,-1036.41 868.15,-1031.82 878.38,-1030.57"/>
+</g>
+<!-- h2o_c&#45;&gt;e_80_center -->
+<g id="edge293" class="edge">
+<title>h2o_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M718.02,-1116.56C703.32,-1090.81 674.85,-1040.99 666.73,-1026.76"/>
+</g>
+<!-- e_3_center&#45;&gt;acon_C_c -->
+<g id="edge13" class="edge">
+<title>e_3_center&#45;&gt;acon_C_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M386.52,-1143.73C367.34,-1150.02 280.36,-1178.53 235.42,-1193.26"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3" points="234.14,-1190 225.73,-1196.44 236.32,-1196.65 234.14,-1190"/>
+</g>
+<!-- e_3_center&#45;&gt;h2o_c -->
+<g id="edge14" class="edge">
+<title>e_3_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M394.02,-1142.39C414.46,-1141.86 515.74,-1139.17 598.5,-1136.59 632.85,-1135.52 672.36,-1134.16 698.4,-1133.24"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3" points="698.81,-1136.73 708.68,-1132.88 698.56,-1129.74 698.81,-1136.73"/>
+</g>
+<!-- icit_c -->
+<g id="node18" class="node">
+<title>icit_c</title>
+<ellipse fill="none" stroke="black" cx="668.2" cy="-1365.43" rx="18" ry="18"/>
+<text text-anchor="middle" x="668.2" y="-1361.73" font-family="Times,serif" font-size="14.00">icit_c</text>
+</g>
+<!-- e_58_center -->
+<g id="node124" class="node">
+<title>e_58_center</title>
+<polygon fill="none" stroke="black" points="1001.97,-1169.74 994.97,-1169.74 994.97,-1162.74 1001.97,-1162.74 1001.97,-1169.74"/>
+</g>
+<!-- icit_c&#45;&gt;e_58_center -->
+<g id="edge202" class="edge">
+<title>icit_c&#45;&gt;e_58_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M683.69,-1356.09C744.39,-1319.48 964.29,-1186.85 994.92,-1168.38"/>
+</g>
+<!-- e_59_center -->
+<g id="node126" class="node">
+<title>e_59_center</title>
+<polygon fill="none" stroke="black" points="543.05,-1617.62 536.05,-1617.62 536.05,-1610.62 543.05,-1610.62 543.05,-1617.62"/>
+</g>
+<!-- icit_c&#45;&gt;e_59_center -->
+<g id="edge206" class="edge">
+<title>icit_c&#45;&gt;e_59_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M659.76,-1381.75C633.6,-1432.32 554.83,-1584.59 541.48,-1610.38"/>
+</g>
+<!-- e_4_center&#45;&gt;icit_c -->
+<g id="edge17" class="edge">
+<title>e_4_center&#45;&gt;icit_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M454.15,-1243.56C476.49,-1256.27 591.98,-1322.03 643.43,-1351.33"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3" points="641.83,-1354.44 652.25,-1356.35 645.29,-1348.36 641.83,-1354.44"/>
+</g>
+<!-- ac_e -->
+<g id="node20" class="node">
+<title>ac_e</title>
+<ellipse fill="none" stroke="black" cx="406.26" cy="-1866.13" rx="18" ry="18"/>
+<text text-anchor="middle" x="406.26" y="-1862.43" font-family="Times,serif" font-size="14.00">ac_e</text>
+</g>
+<!-- e_5_center -->
+<g id="node22" class="node">
+<title>e_5_center</title>
+<polygon fill="none" stroke="black" points="641.65,-1579.97 634.65,-1579.97 634.65,-1572.97 641.65,-1572.97 641.65,-1579.97"/>
+</g>
+<!-- ac_e&#45;&gt;e_5_center -->
+<g id="edge18" class="edge">
+<title>ac_e&#45;&gt;e_5_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M417.76,-1851.77C460.9,-1797.89 611.8,-1609.39 635.11,-1580.26"/>
+</g>
+<!-- e_19_target -->
+<g id="node63" class="node">
+<title>e_19_target</title>
+<ellipse fill="black" stroke="black" cx="236.03" cy="-2074.13" rx="1.8" ry="1.8"/>
+</g>
+<!-- ac_e&#45;&gt;e_19_target -->
+<g id="edge98" class="edge">
+<title>ac_e&#45;&gt;e_19_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M394.83,-1880.1C362.54,-1919.55 271.24,-2031.11 243.88,-2064.55"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="241.02,-2062.51 237.4,-2072.47 246.44,-2066.95 241.02,-2062.51"/>
+</g>
+<!-- h_e -->
+<g id="node21" class="node">
+<title>h_e</title>
+<ellipse fill="none" stroke="black" cx="917.98" cy="-1515.32" rx="18" ry="18"/>
+<text text-anchor="middle" x="917.98" y="-1511.62" font-family="Times,serif" font-size="14.00">h_e</text>
+</g>
+<!-- h_e&#45;&gt;e_5_center -->
+<g id="edge19" class="edge">
+<title>h_e&#45;&gt;e_5_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M900.03,-1518.05C866.5,-1523.28 792.2,-1535.48 730.49,-1550 695.75,-1558.17 654.56,-1571.18 641.98,-1575.23"/>
+</g>
+<!-- e_8_center -->
+<g id="node30" class="node">
+<title>e_8_center</title>
+<polygon fill="none" stroke="black" points="1208.84,-1472.44 1201.84,-1472.44 1201.84,-1465.44 1208.84,-1465.44 1208.84,-1472.44"/>
+</g>
+<!-- h_e&#45;&gt;e_8_center -->
+<g id="edge32" class="edge">
+<title>h_e&#45;&gt;e_8_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M935.45,-1510.95C974.15,-1501.5 1070.18,-1479.27 1152.03,-1470.37 1170.62,-1468.35 1193.06,-1468.63 1201.7,-1468.84"/>
+</g>
+<!-- h_e&#45;&gt;e_11_center -->
+<g id="edge46" class="edge">
+<title>h_e&#45;&gt;e_11_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M909.95,-1499.17C883.31,-1445.55 798.73,-1275.38 785.04,-1247.82"/>
+</g>
+<!-- e_16_center -->
+<g id="node58" class="node">
+<title>e_16_center</title>
+<polygon fill="none" stroke="black" points="1128.72,-1639.08 1121.72,-1639.08 1121.72,-1632.08 1128.72,-1632.08 1128.72,-1639.08"/>
+</g>
+<!-- h_e&#45;&gt;e_16_center -->
+<g id="edge88" class="edge">
+<title>h_e&#45;&gt;e_16_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M933.56,-1524.36C977.24,-1549.71 1099.16,-1620.46 1121.63,-1633.5"/>
+</g>
+<!-- e_18_center -->
+<g id="node62" class="node">
+<title>e_18_center</title>
+<polygon fill="none" stroke="black" points="1079.89,-1678.71 1072.89,-1678.71 1072.89,-1671.71 1079.89,-1671.71 1079.89,-1678.71"/>
+</g>
+<!-- h_e&#45;&gt;e_18_center -->
+<g id="edge94" class="edge">
+<title>h_e&#45;&gt;e_18_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M930.68,-1528.14C964.16,-1561.93 1053.58,-1652.19 1072.74,-1671.53"/>
+</g>
+<!-- e_30_target -->
+<g id="node80" class="node">
+<title>e_30_target</title>
+<ellipse fill="black" stroke="black" cx="998.28" cy="-1791.02" rx="1.8" ry="1.8"/>
+</g>
+<!-- h_e&#45;&gt;e_30_target -->
+<g id="edge109" class="edge">
+<title>h_e&#45;&gt;e_30_target</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.64" d="M923.13,-1532.99C938.22,-1584.8 982.1,-1735.44 994.8,-1779.06"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.64" points="990.94,-1780.32 997.64,-1788.79 998.74,-1778.05 990.94,-1780.32"/>
+</g>
+<!-- e_41_center -->
+<g id="node101" class="node">
+<title>e_41_center</title>
+<polygon fill="none" stroke="black" points="623.85,-1525.03 616.85,-1525.03 616.85,-1518.03 623.85,-1518.03 623.85,-1525.03"/>
+</g>
+<!-- h_e&#45;&gt;e_41_center -->
+<g id="edge126" class="edge">
+<title>h_e&#45;&gt;e_41_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M899.81,-1515.7C840.24,-1516.95 653,-1520.85 624.11,-1521.45"/>
+</g>
+<!-- e_46_center -->
+<g id="node108" class="node">
+<title>e_46_center</title>
+<polygon fill="none" stroke="black" points="1009.41,-1702.36 1002.41,-1702.36 1002.41,-1695.36 1009.41,-1695.36 1009.41,-1702.36"/>
+</g>
+<!-- h_e&#45;&gt;e_46_center -->
+<g id="edge141" class="edge">
+<title>h_e&#45;&gt;e_46_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M925.79,-1531.61C945.12,-1571.97 994.39,-1674.81 1004.2,-1695.29"/>
+</g>
+<!-- e_55_center -->
+<g id="node120" class="node">
+<title>e_55_center</title>
+<polygon fill="none" stroke="black" points="1216.28,-1409.79 1209.28,-1409.79 1209.28,-1402.79 1216.28,-1402.79 1216.28,-1409.79"/>
+</g>
+<!-- h_e&#45;&gt;e_55_center -->
+<g id="edge191" class="edge">
+<title>h_e&#45;&gt;e_55_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M935.11,-1508.99C993.11,-1487.54 1180.15,-1418.36 1209.02,-1407.68"/>
+</g>
+<!-- e_62_center -->
+<g id="node129" class="node">
+<title>e_62_center</title>
+<polygon fill="none" stroke="black" points="1122.92,-1561.31 1115.92,-1561.31 1115.92,-1554.31 1122.92,-1554.31 1122.92,-1561.31"/>
+</g>
+<!-- h_e&#45;&gt;e_62_center -->
+<g id="edge220" class="edge">
+<title>h_e&#45;&gt;e_62_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M935.86,-1519.09C980.34,-1528.48 1094.01,-1552.45 1115.78,-1557.04"/>
+</g>
+<!-- e_77_center -->
+<g id="node140" class="node">
+<title>e_77_center</title>
+<polygon fill="none" stroke="black" points="684.54,-1447.11 677.54,-1447.11 677.54,-1440.11 684.54,-1440.11 684.54,-1447.11"/>
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+<!-- h_e&#45;&gt;e_77_center -->
+<g id="edge276" class="edge">
+<title>h_e&#45;&gt;e_77_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.04" d="M900.56,-1510.05C850.76,-1494.98 709.76,-1452.31 684.83,-1444.76"/>
+</g>
+<!-- e_83_center -->
+<g id="node146" class="node">
+<title>e_83_center</title>
+<polygon fill="none" stroke="black" points="647.66,-1323.57 640.66,-1323.57 640.66,-1316.57 647.66,-1316.57 647.66,-1323.57"/>
+</g>
+<!-- h_e&#45;&gt;e_83_center -->
+<g id="edge308" class="edge">
+<title>h_e&#45;&gt;e_83_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M903.26,-1504.83C850.83,-1467.44 674.87,-1341.97 647.69,-1322.59"/>
+</g>
+<!-- e_86_center -->
+<g id="node148" class="node">
+<title>e_86_center</title>
+<polygon fill="none" stroke="black" points="869.69,-1649.3 862.69,-1649.3 862.69,-1642.3 869.69,-1642.3 869.69,-1649.3"/>
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+<!-- h_e&#45;&gt;e_86_center -->
+<g id="edge314" class="edge">
+<title>h_e&#45;&gt;e_86_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M911.32,-1532.11C899.19,-1562.67 874.16,-1625.73 867.73,-1641.94"/>
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+<!-- e_87_center -->
+<g id="node149" class="node">
+<title>e_87_center</title>
+<polygon fill="none" stroke="black" points="900.54,-1654.28 893.54,-1654.28 893.54,-1647.28 900.54,-1647.28 900.54,-1654.28"/>
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+<!-- h_e&#45;&gt;e_87_center -->
+<g id="edge317" class="edge">
+<title>h_e&#45;&gt;e_87_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M915.2,-1533.31C910.22,-1565.55 900.05,-1631.31 897.58,-1647.24"/>
+</g>
+<!-- h_e&#45;&gt;e_91_center -->
+<g id="edge337" class="edge">
+<title>h_e&#45;&gt;e_91_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M929.5,-1501.22C968.18,-1453.84 1092.2,-1301.94 1113.22,-1276.18"/>
+</g>
+<!-- e_5_center&#45;&gt;h_c -->
+<g id="edge21" class="edge">
+<title>e_5_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M642.01,-1572.71C669.21,-1546.19 832.53,-1387.01 890.78,-1330.22"/>
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+<!-- e_5_center&#45;&gt;ac_c -->
+<g id="edge20" class="edge">
+<title>e_5_center&#45;&gt;ac_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M634.39,-1573.37C611.76,-1554.69 493.04,-1456.68 443.38,-1415.69"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="445.43,-1412.85 435.49,-1409.18 440.97,-1418.24 445.43,-1412.85"/>
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+<!-- amp_c -->
+<g id="node23" class="node">
+<title>amp_c</title>
+<ellipse fill="none" stroke="black" cx="426.43" cy="-860.23" rx="18" ry="18"/>
+<text text-anchor="middle" x="426.43" y="-856.53" font-family="Times,serif" font-size="14.00">amp_c</text>
+</g>
+<!-- amp_c&#45;&gt;e_6_center -->
+<g id="edge23" class="edge">
+<title>amp_c&#45;&gt;e_6_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M442.75,-868.63C466.44,-880.81 508.9,-902.64 521.59,-909.17"/>
+</g>
+<!-- e_6_center&#45;&gt;adp_c -->
+<g id="edge24" class="edge">
+<title>e_6_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M528.93,-912.87C548.85,-922.72 645.04,-970.3 691.66,-993.37"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="690.3,-996.6 700.81,-997.89 693.4,-990.32 690.3,-996.6"/>
+</g>
+<!-- akg_c -->
+<g id="node25" class="node">
+<title>akg_c</title>
+<ellipse fill="none" stroke="black" cx="1166.85" cy="-1189.81" rx="18" ry="18"/>
+<text text-anchor="middle" x="1166.85" y="-1186.11" font-family="Times,serif" font-size="14.00">akg_c</text>
+</g>
+<!-- akg_c&#45;&gt;e_7_center -->
+<g id="edge27" class="edge">
+<title>akg_c&#45;&gt;e_7_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M1149.81,-1196.6C1130.45,-1204.31 1100.24,-1216.35 1090,-1220.43"/>
+</g>
+<!-- akg_c&#45;&gt;e_54_center -->
+<g id="edge188" class="edge">
+<title>akg_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1153.82,-1176.86C1135.84,-1159 1104.43,-1127.8 1093.73,-1117.17"/>
+</g>
+<!-- co2_c -->
+<g id="node26" class="node">
+<title>co2_c</title>
+<ellipse fill="none" stroke="black" cx="1132.22" cy="-954.15" rx="18" ry="18"/>
+<text text-anchor="middle" x="1132.22" y="-950.45" font-family="Times,serif" font-size="14.00">co2_c</text>
+</g>
+<!-- co2_c&#45;&gt;e_78_center -->
+<g id="edge280" class="edge">
+<title>co2_c&#45;&gt;e_78_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.66" d="M1115.28,-960.42C1104.12,-964.48 1089.17,-969.79 1075.82,-974.08 999.73,-998.5 905.35,-1023.92 885.61,-1029.19"/>
+</g>
+<!-- succoa_c -->
+<g id="node27" class="node">
+<title>succoa_c</title>
+<ellipse fill="none" stroke="black" cx="946.22" cy="-1392.43" rx="18" ry="18"/>
+<text text-anchor="middle" x="946.22" y="-1388.73" font-family="Times,serif" font-size="14.00">succoa_c</text>
+</g>
+<!-- e_7_center&#45;&gt;nadh_c -->
+<g id="edge29" class="edge">
+<title>e_7_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M1082.78,-1219.98C1080.07,-1218.61 1076.12,-1216.62 1071.82,-1214.45"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.74" points="1073.27,-1211.26 1062.76,-1209.89 1070.12,-1217.52 1073.27,-1211.26"/>
+</g>
+<!-- e_7_center&#45;&gt;co2_c -->
+<g id="edge28" class="edge">
+<title>e_7_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M1084.75,-1218.11C1081.66,-1211.05 1075.55,-1195.19 1076.08,-1181.22 1077.16,-1152.61 1089.14,-1147.8 1096.73,-1120.2 1109.92,-1072.24 1121.14,-1015.36 1127.26,-982.16"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.74" points="1130.71,-982.71 1129.06,-972.25 1123.82,-981.46 1130.71,-982.71"/>
+</g>
+<!-- e_7_center&#45;&gt;succoa_c -->
+<g id="edge30" class="edge">
+<title>e_7_center&#45;&gt;succoa_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M1084.1,-1225.65C1073.99,-1241.74 1033.17,-1305.38 991.77,-1351.28 984.64,-1359.18 976.14,-1367.18 968.42,-1374"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.74" points="965.74,-1371.69 960.46,-1380.87 970.32,-1376.99 965.74,-1371.69"/>
+</g>
+<!-- akg_e -->
+<g id="node29" class="node">
+<title>akg_e</title>
+<ellipse fill="none" stroke="black" cx="1509.21" cy="-1660.96" rx="18" ry="18"/>
+<text text-anchor="middle" x="1509.21" y="-1657.26" font-family="Times,serif" font-size="14.00">akg_e</text>
+</g>
+<!-- akg_e&#45;&gt;e_8_center -->
+<g id="edge31" class="edge">
+<title>akg_e&#45;&gt;e_8_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1493.72,-1651.17C1436.39,-1614.95 1238.05,-1489.61 1208.92,-1471.21"/>
+</g>
+<!-- e_21_target -->
+<g id="node65" class="node">
+<title>e_21_target</title>
+<ellipse fill="black" stroke="black" cx="1735.18" cy="-1802.02" rx="1.8" ry="1.8"/>
+</g>
+<!-- akg_e&#45;&gt;e_21_target -->
+<g id="edge100" class="edge">
+<title>akg_e&#45;&gt;e_21_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1524.74,-1670.66C1567.93,-1697.62 1688.64,-1772.97 1724.81,-1795.55"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1723.04,-1798.57 1733.38,-1800.89 1726.75,-1792.63 1723.04,-1798.57"/>
+</g>
+<!-- e_8_center&#45;&gt;h_c -->
+<g id="edge33" class="edge">
+<title>e_8_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1201.79,-1467.54C1179.41,-1458.65 1055.75,-1408.52 964.05,-1351.22 953.36,-1344.54 942.25,-1336.12 933.02,-1328.64"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="935.06,-1325.79 925.12,-1322.12 930.6,-1331.19 935.06,-1325.79"/>
+</g>
+<!-- e_8_center&#45;&gt;akg_c -->
+<g id="edge34" class="edge">
+<title>e_8_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1204.85,-1465.41C1201.33,-1439.89 1179.66,-1282.69 1170.71,-1217.79"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1174.17,-1217.28 1169.34,-1207.85 1167.24,-1218.23 1174.17,-1217.28"/>
+</g>
+<!-- etoh_c -->
+<g id="node31" class="node">
+<title>etoh_c</title>
+<ellipse fill="none" stroke="black" cx="1289.88" cy="-1612.42" rx="18" ry="18"/>
+<text text-anchor="middle" x="1289.88" y="-1608.72" font-family="Times,serif" font-size="14.00">etoh_c</text>
+</g>
+<!-- etoh_c&#45;&gt;e_9_center -->
+<g id="edge35" class="edge">
+<title>etoh_c&#45;&gt;e_9_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1284.84,-1594.84C1269.92,-1542.83 1226.58,-1391.74 1219.24,-1366.16"/>
+</g>
+<!-- e_9_center&#45;&gt;acald_c -->
+<g id="edge38" class="edge">
+<title>e_9_center&#45;&gt;acald_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1222.03,-1362.65C1246.16,-1363.89 1377.16,-1370.59 1435.58,-1373.58"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1435.44,-1377.07 1445.6,-1374.09 1435.8,-1370.08 1435.44,-1377.07"/>
+</g>
+<!-- e_9_center&#45;&gt;nadh_c -->
+<g id="edge37" class="edge">
+<title>e_9_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1214.67,-1358.64C1202.43,-1345.38 1160.37,-1300.26 1122.97,-1265.75 1113.15,-1256.69 1087.41,-1235.3 1068.48,-1219.72"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1070.55,-1216.89 1060.6,-1213.25 1066.1,-1222.3 1070.55,-1216.89"/>
+</g>
+<!-- e_9_center&#45;&gt;h_c -->
+<g id="edge39" class="edge">
+<title>e_9_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1214.52,-1361.68C1192.47,-1357.01 1074.87,-1332.37 977.98,-1317.79 965.47,-1315.91 951.58,-1314.24 939.74,-1312.95"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="939.85,-1309.44 929.54,-1311.86 939.11,-1316.4 939.85,-1309.44"/>
+</g>
+<!-- pi_c -->
+<g id="node33" class="node">
+<title>pi_c</title>
+<ellipse fill="none" stroke="black" cx="774.55" cy="-1104.66" rx="18" ry="18"/>
+<text text-anchor="middle" x="774.55" y="-1100.96" font-family="Times,serif" font-size="14.00">pi_c</text>
+</g>
+<!-- pi_c&#45;&gt;e_11_center -->
+<g id="edge45" class="edge">
+<title>pi_c&#45;&gt;e_11_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M775.68,-1122.88C777.72,-1155.94 781.91,-1223.9 782.93,-1240.38"/>
+</g>
+<!-- pi_c&#45;&gt;e_48_center -->
+<g id="edge150" class="edge">
+<title>pi_c&#45;&gt;e_48_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.51" d="M792.07,-1099.39C806.52,-1094.63 827.22,-1086.81 843.61,-1076.65 903.33,-1039.62 958.93,-972.19 971.89,-955.91"/>
+</g>
+<!-- pi_c&#45;&gt;e_81_center -->
+<g id="edge299" class="edge">
+<title>pi_c&#45;&gt;e_81_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M756.7,-1107.12C715.56,-1112.8 616.07,-1126.54 595.54,-1129.38"/>
+</g>
+<!-- e_10_center&#45;&gt;h_c -->
+<g id="edge43" class="edge">
+<title>e_10_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.51" d="M711.92,-1182.98C732.59,-1196.16 838.91,-1263.91 887.33,-1294.77"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.51" points="885.62,-1297.83 895.94,-1300.25 889.38,-1291.93 885.62,-1297.83"/>
+</g>
+<!-- e_10_center&#45;&gt;adp_c -->
+<g id="edge44" class="edge">
+<title>e_10_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.51" d="M707.75,-1177.07C705.16,-1161.57 695.84,-1099.88 702.72,-1049.86 703.51,-1044.1 705.01,-1038.08 706.75,-1032.41"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.51" points="710.14,-1033.31 710.04,-1022.71 703.51,-1031.05 710.14,-1033.31"/>
+</g>
+<!-- e_10_center&#45;&gt;pi_c -->
+<g id="edge42" class="edge">
+<title>e_10_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.51" d="M711.88,-1177.17C717.92,-1170.97 730.63,-1157.76 740.82,-1146.09 746.11,-1140.04 751.68,-1133.34 756.73,-1127.12"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.51" points="759.69,-1129.03 763.24,-1119.05 754.24,-1124.64 759.69,-1129.03"/>
+</g>
+<!-- e_11_center&#45;&gt;h_c -->
+<g id="edge50" class="edge">
+<title>e_11_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M786.86,-1245.94C801.22,-1253.34 854.1,-1280.59 886.16,-1297.1"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="884.48,-1301.16 895.38,-1301.85 888.49,-1293.38 884.48,-1301.16"/>
+</g>
+<!-- e_11_center&#45;&gt;atp_c -->
+<g id="edge48" class="edge">
+<title>e_11_center&#45;&gt;atp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M781.99,-1240.33C775.74,-1220.36 745.74,-1124.69 730.8,-1077.06"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="734.94,-1075.63 727.77,-1067.39 726.59,-1078.25 734.94,-1075.63"/>
+</g>
+<!-- e_11_center&#45;&gt;h2o_c -->
+<g id="edge49" class="edge">
+<title>e_11_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M781.29,-1240.31C774.92,-1227.64 753.68,-1185.38 739.73,-1157.61"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="743.53,-1155.43 735.13,-1148.46 735.71,-1159.36 743.53,-1155.43"/>
+</g>
+<!-- nadph_c -->
+<g id="node36" class="node">
+<title>nadph_c</title>
+<ellipse fill="none" stroke="black" cx="1159.98" cy="-1014.03" rx="18" ry="18"/>
+<text text-anchor="middle" x="1159.98" y="-1010.33" font-family="Times,serif" font-size="14.00">nadph_c</text>
+</g>
+<!-- nadph_c&#45;&gt;e_12_center -->
+<g id="edge51" class="edge">
+<title>nadph_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M1143.23,-1007.27C1102.04,-990.7 998.02,-949.16 981.42,-945.6 971.58,-943.49 959.63,-943.49 953.69,-943.66"/>
+</g>
+<!-- nadph_c&#45;&gt;e_54_center -->
+<g id="edge186" class="edge">
+<title>nadph_c&#45;&gt;e_54_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1149.36,-1029.14C1132.85,-1052.62 1101.96,-1096.53 1092.71,-1109.68"/>
+</g>
+<!-- nadph_c&#45;&gt;e_67_center -->
+<g id="edge245" class="edge">
+<title>nadph_c&#45;&gt;e_67_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1175.22,-1024.3C1184.89,-1031.13 1197.42,-1040.58 1207.46,-1050.17 1237.21,-1078.6 1266.83,-1118.9 1275.75,-1131.36"/>
+</g>
+<!-- g3p_c -->
+<g id="node37" class="node">
+<title>g3p_c</title>
+<ellipse fill="none" stroke="black" cx="1021.46" cy="-580.96" rx="18" ry="18"/>
+<text text-anchor="middle" x="1021.46" y="-577.26" font-family="Times,serif" font-size="14.00">g3p_c</text>
+</g>
+<!-- g3p_c&#45;&gt;e_12_center -->
+<g id="edge52" class="edge">
+<title>g3p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M1017.92,-598.95C1004.5,-667.02 957.29,-906.6 950.72,-939.95"/>
+</g>
+<!-- g3p_c&#45;&gt;e_48_center -->
+<g id="edge152" class="edge">
+<title>g3p_c&#45;&gt;e_48_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.51" d="M1019.21,-598.87C1010.49,-668.12 979.28,-916.12 975.17,-948.75"/>
+</g>
+<!-- e_90_center -->
+<g id="node153" class="node">
+<title>e_90_center</title>
+<polygon fill="none" stroke="black" points="1065.65,-407.95 1058.65,-407.95 1058.65,-400.95 1065.65,-400.95 1065.65,-407.95"/>
+</g>
+<!-- g3p_c&#45;&gt;e_90_center -->
+<g id="edge332" class="edge">
+<title>g3p_c&#45;&gt;e_90_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.87" d="M1025.51,-563.39C1034.72,-523.45 1056.77,-427.78 1061.32,-408.05"/>
+</g>
+<!-- glu__L_c -->
+<g id="node38" class="node">
+<title>glu__L_c</title>
+<ellipse fill="none" stroke="black" cx="1150.94" cy="-1115.12" rx="18" ry="18"/>
+<text text-anchor="middle" x="1150.94" y="-1111.42" font-family="Times,serif" font-size="14.00">glu__L_c</text>
+</g>
+<!-- glu__L_c&#45;&gt;e_12_center -->
+<g id="edge53" class="edge">
+<title>glu__L_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M1137.12,-1103.35C1095.97,-1068.27 975.69,-965.75 953.5,-946.84"/>
+</g>
+<!-- glu__L_c&#45;&gt;e_50_center -->
+<g id="edge161" class="edge">
+<title>glu__L_c&#45;&gt;e_50_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.55" d="M1133.87,-1108.47C1091.59,-1092 983.84,-1050.04 962.39,-1041.68"/>
+</g>
+<!-- glu__L_c&#45;&gt;e_52_center -->
+<g id="edge176" class="edge">
+<title>glu__L_c&#45;&gt;e_52_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.57" d="M1132.88,-1111.93C1109.63,-1107.81 1070.78,-1100.94 1058.66,-1098.8"/>
+</g>
+<!-- oaa_c -->
+<g id="node39" class="node">
+<title>oaa_c</title>
+<ellipse fill="none" stroke="black" cx="829.84" cy="-1062.7" rx="18" ry="18"/>
+<text text-anchor="middle" x="829.84" y="-1059" font-family="Times,serif" font-size="14.00">oaa_c</text>
+</g>
+<!-- oaa_c&#45;&gt;e_12_center -->
+<g id="edge54" class="edge">
+<title>oaa_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M842.7,-1049.97C869.57,-1023.38 930.5,-963.08 946.21,-947.53"/>
+</g>
+<!-- oaa_c&#45;&gt;e_14_center -->
+<g id="edge77" class="edge">
+<title>oaa_c&#45;&gt;e_14_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M819.62,-1077.95C811.62,-1089.51 799.95,-1105.55 788.39,-1118.53 758.66,-1151.93 751,-1160.79 715.09,-1187.43 697.33,-1200.61 673.51,-1212.57 664.57,-1216.88"/>
+</g>
+<!-- oaa_c&#45;&gt;e_79_center -->
+<g id="edge287" class="edge">
+<title>oaa_c&#45;&gt;e_79_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M834.24,-1045.12C843.94,-1006.38 866.69,-915.55 871.55,-896.14"/>
+</g>
+<!-- pyr_c -->
+<g id="node40" class="node">
+<title>pyr_c</title>
+<ellipse fill="none" stroke="black" cx="793.8" cy="-978.37" rx="18" ry="18"/>
+<text text-anchor="middle" x="793.8" y="-974.67" font-family="Times,serif" font-size="14.00">pyr_c</text>
+</g>
+<!-- pyr_c&#45;&gt;e_12_center -->
+<g id="edge55" class="edge">
+<title>pyr_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M810.55,-971.36C827,-964.8 852.97,-955.28 876.37,-950.34 902.73,-944.78 935.36,-943.96 946.24,-943.84"/>
+</g>
+<!-- pyr_c&#45;&gt;e_70_center -->
+<g id="edge252" class="edge">
+<title>pyr_c&#45;&gt;e_70_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.67" d="M808.15,-989.47C824.14,-1001.65 850.94,-1021.51 875.19,-1036.88 905.29,-1055.96 943.67,-1075.66 955.46,-1081.61"/>
+</g>
+<!-- pyr_c&#45;&gt;e_72_center -->
+<g id="edge263" class="edge">
+<title>pyr_c&#45;&gt;e_72_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M783.82,-993.68C772.5,-1010.93 753.36,-1039.72 736.09,-1063.93 690.78,-1127.45 632.31,-1202.49 618.41,-1220.26"/>
+</g>
+<!-- pyr_c&#45;&gt;e_80_center -->
+<g id="edge292" class="edge">
+<title>pyr_c&#45;&gt;e_80_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M775.49,-977.28C756.21,-976.97 725.63,-978.93 703.28,-992.05 689.34,-1000.23 674.97,-1013.03 668.31,-1019.24"/>
+</g>
+<!-- e4p_c -->
+<g id="node41" class="node">
+<title>e4p_c</title>
+<ellipse fill="none" stroke="black" cx="1070.84" cy="-611.61" rx="18" ry="18"/>
+<text text-anchor="middle" x="1070.84" y="-607.91" font-family="Times,serif" font-size="14.00">e4p_c</text>
+</g>
+<!-- e4p_c&#45;&gt;e_12_center -->
+<g id="edge56" class="edge">
+<title>e4p_c&#45;&gt;e_12_center</title>
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+<!-- e4p_c&#45;&gt;e_93_center -->
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+<title>e4p_c&#45;&gt;e_93_center</title>
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+<!-- r5p_c -->
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+</g>
+<!-- r5p_c&#45;&gt;e_12_center -->
+<g id="edge57" class="edge">
+<title>r5p_c&#45;&gt;e_12_center</title>
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+<!-- ru5p__D_c -->
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+<!-- r5p_c&#45;&gt;ru5p__D_c -->
+<g id="edge312" class="edge">
+<title>r5p_c&#45;&gt;ru5p__D_c</title>
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+<!-- e_92_center -->
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+<!-- r5p_c&#45;&gt;e_92_center -->
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+<title>r5p_c&#45;&gt;e_92_center</title>
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+<!-- gln__L_c -->
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+</g>
+<!-- gln__L_c&#45;&gt;e_12_center -->
+<g id="edge59" class="edge">
+<title>gln__L_c&#45;&gt;e_12_center</title>
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+<!-- gln__L_c&#45;&gt;e_53_center -->
+<g id="edge182" class="edge">
+<title>gln__L_c&#45;&gt;e_53_center</title>
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+</g>
+<!-- gln__L_c&#45;&gt;e_54_center -->
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+<title>gln__L_c&#45;&gt;e_54_center</title>
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+<!-- g6p_c -->
+<g id="node44" class="node">
+<title>g6p_c</title>
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+<text text-anchor="middle" x="920.29" y="-737.12" font-family="Times,serif" font-size="14.00">g6p_c</text>
+</g>
+<!-- f6p_c -->
+<g id="node46" class="node">
+<title>f6p_c</title>
+<ellipse fill="none" stroke="black" cx="934.92" cy="-649.11" rx="18" ry="18"/>
+<text text-anchor="middle" x="934.92" y="-645.41" font-family="Times,serif" font-size="14.00">f6p_c</text>
+</g>
+<!-- g6p_c&#45;&gt;f6p_c -->
+<g id="edge266" class="edge">
+<title>g6p_c&#45;&gt;f6p_c</title>
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+<!-- g6p_c&#45;&gt;e_12_center -->
+<g id="edge60" class="edge">
+<title>g6p_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M922.92,-758.83C929.48,-803.66 946.22,-918.21 949.42,-940.15"/>
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+<!-- e_47_center -->
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+<title>e_47_center</title>
+<polygon fill="none" stroke="black" points="1072.62,-970.88 1065.62,-970.88 1065.62,-963.88 1072.62,-963.88 1072.62,-970.88"/>
+</g>
+<!-- g6p_c&#45;&gt;e_47_center -->
+<g id="edge146" class="edge">
+<title>g6p_c&#45;&gt;e_47_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M930.29,-756.03C960.66,-802.27 1050.75,-939.41 1066.7,-963.68"/>
+</g>
+<!-- pep_c -->
+<g id="node45" class="node">
+<title>pep_c</title>
+<ellipse fill="none" stroke="black" cx="744.99" cy="-829.05" rx="18" ry="18"/>
+<text text-anchor="middle" x="744.99" y="-825.35" font-family="Times,serif" font-size="14.00">pep_c</text>
+</g>
+<!-- pep_c&#45;&gt;e_12_center -->
+<g id="edge61" class="edge">
+<title>pep_c&#45;&gt;e_12_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M760.51,-838.32C783.4,-851.92 827.61,-877.97 865.77,-899.15 896.73,-916.34 934.76,-936 946.4,-941.99"/>
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+<!-- e_44_center -->
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+</g>
+<!-- pep_c&#45;&gt;e_44_center -->
+<g id="edge135" class="edge">
+<title>pep_c&#45;&gt;e_44_center</title>
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+<!-- e_49_center -->
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+<!-- pep_c&#45;&gt;e_49_center -->
+<g id="edge157" class="edge">
+<title>pep_c&#45;&gt;e_49_center</title>
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+<!-- pep_c&#45;&gt;e_78_center -->
+<g id="edge281" class="edge">
+<title>pep_c&#45;&gt;e_78_center</title>
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+<!-- pep_c&#45;&gt;e_82_center -->
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+<title>pep_c&#45;&gt;e_82_center</title>
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+</g>
+<!-- f6p_c&#45;&gt;e_12_center -->
+<g id="edge64" class="edge">
+<title>f6p_c&#45;&gt;e_12_center</title>
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+<!-- f6p_c&#45;&gt;e_71_center -->
+<g id="edge258" class="edge">
+<title>f6p_c&#45;&gt;e_71_center</title>
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+<!-- 3pg_c -->
+<g id="node47" class="node">
+<title>3pg_c</title>
+<ellipse fill="none" stroke="black" cx="722.61" cy="-704.24" rx="18" ry="18"/>
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+</g>
+<!-- 3pg_c&#45;&gt;e_12_center -->
+<g id="edge65" class="edge">
+<title>3pg_c&#45;&gt;e_12_center</title>
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+</g>
+<!-- 3pg_c&#45;&gt;e_74_center -->
+<g id="edge267" class="edge">
+<title>3pg_c&#45;&gt;e_74_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.96" d="M713.58,-720.35C699.74,-745.04 674.12,-790.76 666.81,-803.79"/>
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+<!-- nadp_c -->
+<g id="node48" class="node">
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+<ellipse fill="none" stroke="black" cx="1193.56" cy="-1063.99" rx="18" ry="18"/>
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+<!-- nadp_c&#45;&gt;e_47_center -->
+<g id="edge145" class="edge">
+<title>nadp_c&#45;&gt;e_47_center</title>
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+<!-- nadp_c&#45;&gt;e_52_center -->
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+<title>nadp_c&#45;&gt;e_52_center</title>
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+<!-- e_56_center -->
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+<!-- nadp_c&#45;&gt;e_56_center -->
+<g id="edge195" class="edge">
+<title>nadp_c&#45;&gt;e_56_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1197.91,-1046.12C1205.36,-1017.18 1222.12,-958.74 1246.08,-913.5 1264.3,-879.09 1292.07,-840.87 1300.69,-829.25"/>
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+<!-- nadp_c&#45;&gt;e_58_center -->
+<g id="edge201" class="edge">
+<title>nadp_c&#45;&gt;e_58_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M1178.03,-1073.57C1159.1,-1085.12 1126.01,-1104.88 1096.73,-1120.2 1060.67,-1139.06 1015.51,-1158.87 1002.27,-1164.6"/>
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+<!-- e_65_center -->
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+<!-- nadp_c&#45;&gt;e_65_center -->
+<g id="edge235" class="edge">
+<title>nadp_c&#45;&gt;e_65_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1175.29,-1063.67C1138.82,-1063.03 1058.93,-1061.64 1040.71,-1061.32"/>
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+<!-- nadp_c&#45;&gt;e_91_center -->
+<g id="edge335" class="edge">
+<title>nadp_c&#45;&gt;e_91_center</title>
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+<!-- e_12_center&#45;&gt;coa_c -->
+<g id="edge72" class="edge">
+<title>e_12_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M948.6,-947.57C939.4,-973.01 885.86,-1121 863.61,-1182.49"/>
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+<!-- e_12_center&#45;&gt;nadh_c -->
+<g id="edge68" class="edge">
+<title>e_12_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M951.32,-947.46C960.55,-972.12 1014.12,-1115.25 1036.56,-1175.24"/>
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+<!-- e_12_center&#45;&gt;h_c -->
+<g id="edge70" class="edge">
+<title>e_12_center&#45;&gt;h_c</title>
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+<!-- e_12_center&#45;&gt;adp_c -->
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+<title>e_12_center&#45;&gt;adp_c</title>
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+<!-- e_12_center&#45;&gt;akg_c -->
+<g id="edge71" class="edge">
+<title>e_12_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="0.46" d="M953.2,-947.34C969.09,-964.58 1040.16,-1041.95 1096.73,-1106.8 1114.58,-1127.26 1134.52,-1150.95 1148.56,-1167.77"/>
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+<!-- e_12_center&#45;&gt;pi_c -->
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+<!-- e_12_center&#45;&gt;nadp_c -->
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+<!-- co2_e -->
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+<ellipse fill="none" stroke="black" cx="1465.37" cy="-728.13" rx="18" ry="18"/>
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+<!-- co2_e&#45;&gt;co2_c -->
+<g id="edge74" class="edge">
+<title>co2_e&#45;&gt;co2_c</title>
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+<!-- e_22_target -->
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+<title>e_22_target</title>
+<ellipse fill="black" stroke="black" cx="1684.99" cy="-570.23" rx="1.8" ry="1.8"/>
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+<!-- co2_e&#45;&gt;e_22_target -->
+<g id="edge101" class="edge">
+<title>co2_e&#45;&gt;e_22_target</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M1480.12,-717.53C1521.78,-687.58 1639.56,-602.89 1674.87,-577.51"/>
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+<!-- e_14_center&#45;&gt;coa_c -->
+<g id="edge79" class="edge">
+<title>e_14_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M664.65,-1218.4C684.32,-1217.45 777.85,-1212.94 825.65,-1210.64"/>
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+<!-- e_14_center&#45;&gt;h_c -->
+<g id="edge80" class="edge">
+<title>e_14_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M664.51,-1219.87C688.29,-1228.57 825.6,-1278.75 884.55,-1300.29"/>
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+<!-- e_14_center&#45;&gt;cit_c -->
+<g id="edge78" class="edge">
+<title>e_14_center&#45;&gt;cit_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M657.42,-1218.34C648.96,-1217.82 626.98,-1216.66 608.64,-1217.46 531.74,-1220.86 441.4,-1230.33 396.58,-1235.4"/>
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+<!-- o2_c -->
+<g id="node52" class="node">
+<title>o2_c</title>
+<ellipse fill="none" stroke="black" cx="558.29" cy="-1940.84" rx="18" ry="18"/>
+<text text-anchor="middle" x="558.29" y="-1937.14" font-family="Times,serif" font-size="14.00">o2_c</text>
+</g>
+<!-- o2_c&#45;&gt;e_15_center -->
+<g id="edge81" class="edge">
+<title>o2_c&#45;&gt;e_15_center</title>
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+<!-- q8h2_c&#45;&gt;e_15_center -->
+<g id="edge82" class="edge">
+<title>q8h2_c&#45;&gt;e_15_center</title>
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+<!-- e_43_center -->
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+<!-- q8h2_c&#45;&gt;e_43_center -->
+<g id="edge130" class="edge">
+<title>q8h2_c&#45;&gt;e_43_center</title>
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+<!-- q8_c -->
+<g id="node54" class="node">
+<title>q8_c</title>
+<ellipse fill="none" stroke="black" cx="845.94" cy="-1731.79" rx="18" ry="18"/>
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+</g>
+<!-- q8_c&#45;&gt;e_66_center -->
+<g id="edge239" class="edge">
+<title>q8_c&#45;&gt;e_66_center</title>
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+<!-- e_88_center -->
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+<!-- q8_c&#45;&gt;e_88_center -->
+<g id="edge321" class="edge">
+<title>q8_c&#45;&gt;e_88_center</title>
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+<!-- e_15_center&#45;&gt;h2o_c -->
+<g id="edge86" class="edge">
+<title>e_15_center&#45;&gt;h2o_c</title>
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+<!-- e_15_center&#45;&gt;h_e -->
+<g id="edge85" class="edge">
+<title>e_15_center&#45;&gt;h_e</title>
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+<!-- e_15_center&#45;&gt;q8_c -->
+<g id="edge84" class="edge">
+<title>e_15_center&#45;&gt;q8_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M739.46,-1560.36C751.11,-1579.11 804.64,-1665.3 831.08,-1707.87"/>
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+<!-- lac__D_e -->
+<g id="node56" class="node">
+<title>lac__D_e</title>
+<ellipse fill="none" stroke="black" cx="1328.12" cy="-1933.24" rx="18" ry="18"/>
+<text text-anchor="middle" x="1328.12" y="-1929.54" font-family="Times,serif" font-size="14.00">lac__D_e</text>
+</g>
+<!-- lac__D_e&#45;&gt;e_16_center -->
+<g id="edge87" class="edge">
+<title>lac__D_e&#45;&gt;e_16_center</title>
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+</g>
+<!-- e_32_target -->
+<g id="node83" class="node">
+<title>e_32_target</title>
+<ellipse fill="black" stroke="black" cx="1480.69" cy="-2153.52" rx="1.8" ry="1.8"/>
+</g>
+<!-- lac__D_e&#45;&gt;e_32_target -->
+<g id="edge111" class="edge">
+<title>lac__D_e&#45;&gt;e_32_target</title>
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+<!-- lac__D_c -->
+<g id="node57" class="node">
+<title>lac__D_c</title>
+<ellipse fill="none" stroke="black" cx="1151.88" cy="-1489.97" rx="18" ry="18"/>
+<text text-anchor="middle" x="1151.88" y="-1486.27" font-family="Times,serif" font-size="14.00">lac__D_c</text>
+</g>
+<!-- lac__D_c&#45;&gt;e_60_center -->
+<g id="edge209" class="edge">
+<title>lac__D_c&#45;&gt;e_60_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1141.63,-1474.72C1110.02,-1427.66 1015.11,-1286.36 998.32,-1261.35"/>
+</g>
+<!-- e_16_center&#45;&gt;h_c -->
+<g id="edge90" class="edge">
+<title>e_16_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1122.95,-1631.92C1108.63,-1608.77 1029.03,-1480.52 960.11,-1378.6 949.75,-1363.28 937.71,-1346.34 928.2,-1333.15"/>
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+</g>
+<!-- e_16_center&#45;&gt;lac__D_c -->
+<g id="edge89" class="edge">
+<title>e_16_center&#45;&gt;lac__D_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1125.88,-1631.98C1128.71,-1616.52 1140,-1554.83 1146.74,-1518.03"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1150.23,-1518.4 1148.59,-1507.94 1143.34,-1517.14 1150.23,-1518.4"/>
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+<!-- 2pg_c -->
+<g id="node59" class="node">
+<title>2pg_c</title>
+<ellipse fill="none" stroke="black" cx="497.28" cy="-600.44" rx="18" ry="18"/>
+<text text-anchor="middle" x="497.28" y="-596.74" font-family="Times,serif" font-size="14.00">2pg_c</text>
+</g>
+<!-- 2pg_c&#45;&gt;3pg_c -->
+<g id="edge275" class="edge">
+<title>2pg_c&#45;&gt;3pg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.96" d="M513.85,-608.07C552.75,-625.99 650.17,-670.87 696.86,-692.38"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.96" points="695.47,-695.59 706.02,-696.6 698.4,-689.24 695.47,-695.59"/>
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+<!-- e_17_center -->
+<g id="node60" class="node">
+<title>e_17_center</title>
+<polygon fill="none" stroke="black" points="571.44,-825.54 564.44,-825.54 564.44,-818.54 571.44,-818.54 571.44,-825.54"/>
+</g>
+<!-- 2pg_c&#45;&gt;e_17_center -->
+<g id="edge91" class="edge">
+<title>2pg_c&#45;&gt;e_17_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.38" d="M502.82,-617.83C517.92,-665.17 559.14,-794.42 566.73,-818.24"/>
+</g>
+<!-- e_17_center&#45;&gt;h2o_c -->
+<g id="edge93" class="edge">
+<title>e_17_center&#45;&gt;h2o_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.38" d="M569.97,-825.72C580.7,-845.2 631.92,-938.52 671.21,-1016.18 686.75,-1046.9 703.77,-1082.65 714.87,-1106.27"/>
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+<!-- e_17_center&#45;&gt;pep_c -->
+<g id="edge92" class="edge">
+<title>e_17_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.38" d="M571.64,-822.19C590.04,-822.92 672.56,-826.18 716.78,-827.93"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.38" points="716.74,-831.76 726.88,-828.33 717.04,-824.11 716.74,-831.76"/>
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+<!-- etoh_e -->
+<g id="node61" class="node">
+<title>etoh_e</title>
+<ellipse fill="none" stroke="black" cx="1127.45" cy="-2036.97" rx="18" ry="18"/>
+<text text-anchor="middle" x="1127.45" y="-2033.27" font-family="Times,serif" font-size="14.00">etoh_e</text>
+</g>
+<!-- etoh_e&#45;&gt;e_18_center -->
+<g id="edge95" class="edge">
+<title>etoh_e&#45;&gt;e_18_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1124.92,-2019.03C1115.34,-1951.17 1081.63,-1712.31 1076.93,-1679.06"/>
+</g>
+<!-- e_23_target -->
+<g id="node67" class="node">
+<title>e_23_target</title>
+<ellipse fill="black" stroke="black" cx="1179.89" cy="-2295.78" rx="1.8" ry="1.8"/>
+</g>
+<!-- etoh_e&#45;&gt;e_23_target -->
+<g id="edge102" class="edge">
+<title>etoh_e&#45;&gt;e_23_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1131.06,-2054.76C1141.08,-2104.22 1169.09,-2242.48 1177.48,-2283.9"/>
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+</g>
+<!-- e_18_center&#45;&gt;h_c -->
+<g id="edge97" class="edge">
+<title>e_18_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1075.35,-1671.52C1068.01,-1645.9 1022.63,-1491.92 960.11,-1378.6 951.09,-1362.25 938.92,-1345.14 929,-1332.1"/>
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+<!-- e_18_center&#45;&gt;etoh_c -->
+<g id="edge96" class="edge">
+<title>e_18_center&#45;&gt;etoh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1080.1,-1674.12C1101.54,-1667.81 1210.59,-1635.74 1262.44,-1620.49"/>
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+<!-- e_24_target -->
+<g id="node68" class="node">
+<title>e_24_target</title>
+<ellipse fill="black" stroke="black" cx="66.67" cy="-1786.44" rx="1.8" ry="1.8"/>
+</g>
+<!-- for_e -->
+<g id="node69" class="node">
+<title>for_e</title>
+<ellipse fill="none" stroke="black" cx="300.68" cy="-1655.94" rx="18" ry="18"/>
+<text text-anchor="middle" x="300.68" y="-1652.24" font-family="Times,serif" font-size="14.00">for_e</text>
+</g>
+<!-- for_e&#45;&gt;e_24_target -->
+<g id="edge103" class="edge">
+<title>for_e&#45;&gt;e_24_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M284.6,-1664.91C239.87,-1689.85 114.86,-1759.57 77.4,-1780.46"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="75.56,-1777.48 68.53,-1785.4 78.97,-1783.59 75.56,-1777.48"/>
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+<!-- for_e&#45;&gt;e_41_center -->
+<g id="edge125" class="edge">
+<title>for_e&#45;&gt;e_41_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M317.42,-1648.91C378.31,-1623.3 586.09,-1535.94 616.6,-1523.11"/>
+</g>
+<!-- e_25_target -->
+<g id="node70" class="node">
+<title>e_25_target</title>
+<ellipse fill="black" stroke="black" cx="573.51" cy="-1.74" rx="1.8" ry="1.8"/>
+</g>
+<!-- fru_e -->
+<g id="node71" class="node">
+<title>fru_e</title>
+<ellipse fill="none" stroke="black" cx="639.15" cy="-248.46" rx="18" ry="18"/>
+<text text-anchor="middle" x="639.15" y="-244.76" font-family="Times,serif" font-size="14.00">fru_e</text>
+</g>
+<!-- fru_e&#45;&gt;e_25_target -->
+<g id="edge104" class="edge">
+<title>fru_e&#45;&gt;e_25_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M634.43,-230.71C621.75,-183.07 587.21,-53.24 576.63,-13.47"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="579.98,-12.45 574.03,-3.69 573.21,-14.25 579.98,-12.45"/>
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+<!-- fru_e&#45;&gt;e_44_center -->
+<g id="edge134" class="edge">
+<title>fru_e&#45;&gt;e_44_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M644.05,-266.2C662.27,-332.13 725.48,-560.96 734.27,-592.81"/>
+</g>
+<!-- e_26_target -->
+<g id="node72" class="node">
+<title>e_26_target</title>
+<ellipse fill="black" stroke="black" cx="1276.35" cy="-2268.64" rx="1.8" ry="1.8"/>
+</g>
+<!-- fum_e -->
+<g id="node73" class="node">
+<title>fum_e</title>
+<ellipse fill="none" stroke="black" cx="1172.91" cy="-2025.98" rx="18" ry="18"/>
+<text text-anchor="middle" x="1172.91" y="-2022.28" font-family="Times,serif" font-size="14.00">fum_e</text>
+</g>
+<!-- fum_e&#45;&gt;e_26_target -->
+<g id="edge105" class="edge">
+<title>fum_e&#45;&gt;e_26_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1180.02,-2042.66C1199.79,-2089.04 1255.05,-2218.67 1271.6,-2257.51"/>
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+<!-- fum_e&#45;&gt;e_46_center -->
+<g id="edge142" class="edge">
+<title>fum_e&#45;&gt;e_46_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1164.63,-2009.76C1133.43,-1948.65 1023.97,-1734.23 1007.89,-1702.74"/>
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+<!-- e_27_target -->
+<g id="node74" class="node">
+<title>e_27_target</title>
+<ellipse fill="black" stroke="black" cx="368.59" cy="-97.54" rx="1.8" ry="1.8"/>
+</g>
+<!-- glc__D_e -->
+<g id="node75" class="node">
+<title>glc__D_e</title>
+<ellipse fill="none" stroke="black" cx="497.17" cy="-318.79" rx="18" ry="18"/>
+<text text-anchor="middle" x="497.17" y="-315.09" font-family="Times,serif" font-size="14.00">glc__D_e</text>
+</g>
+<!-- glc__D_e&#45;&gt;e_27_target -->
+<g id="edge106" class="edge">
+<title>glc__D_e&#45;&gt;e_27_target</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.78" d="M487.92,-302.88C463.09,-260.15 395.43,-143.73 374.7,-108.07"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.78" points="377.66,-106.18 369.61,-99.29 371.6,-109.7 377.66,-106.18"/>
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+<!-- glc__D_e&#45;&gt;e_49_center -->
+<g id="edge156" class="edge">
+<title>glc__D_e&#45;&gt;e_49_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.78" d="M506.27,-334.43C540.55,-393.36 660.83,-600.14 678.49,-630.51"/>
+</g>
+<!-- e_28_target -->
+<g id="node76" class="node">
+<title>e_28_target</title>
+<ellipse fill="black" stroke="black" cx="50.77" cy="-721.47" rx="1.8" ry="1.8"/>
+</g>
+<!-- gln__L_e -->
+<g id="node77" class="node">
+<title>gln__L_e</title>
+<ellipse fill="none" stroke="black" cx="285.16" cy="-852.78" rx="18" ry="18"/>
+<text text-anchor="middle" x="285.16" y="-849.08" font-family="Times,serif" font-size="14.00">gln__L_e</text>
+</g>
+<!-- gln__L_e&#45;&gt;e_28_target -->
+<g id="edge107" class="edge">
+<title>gln__L_e&#45;&gt;e_28_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M269.42,-843.96C224.96,-819.06 99.25,-748.63 61.57,-727.52"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="63.08,-724.36 52.65,-722.53 59.66,-730.47 63.08,-724.36"/>
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+<!-- gln__L_e&#45;&gt;e_51_center -->
+<g id="edge168" class="edge">
+<title>gln__L_e&#45;&gt;e_51_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M301.05,-861.64C363.36,-896.36 589.05,-1022.16 620.49,-1039.67"/>
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+<!-- e_29_target -->
+<g id="node78" class="node">
+<title>e_29_target</title>
+<ellipse fill="black" stroke="black" cx="1800.55" cy="-1618.66" rx="1.8" ry="1.8"/>
+</g>
+<!-- glu__L_e -->
+<g id="node79" class="node">
+<title>glu__L_e</title>
+<ellipse fill="none" stroke="black" cx="1551.02" cy="-1527.4" rx="18" ry="18"/>
+<text text-anchor="middle" x="1551.02" y="-1523.7" font-family="Times,serif" font-size="14.00">glu__L_e</text>
+</g>
+<!-- glu__L_e&#45;&gt;e_29_target -->
+<g id="edge108" class="edge">
+<title>glu__L_e&#45;&gt;e_29_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1568.17,-1533.67C1615.86,-1551.12 1749.16,-1599.87 1789.1,-1614.48"/>
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+<!-- glu__L_e&#45;&gt;e_55_center -->
+<g id="edge192" class="edge">
+<title>glu__L_e&#45;&gt;e_55_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1533.78,-1521.23C1469.7,-1498.28 1247.32,-1418.66 1216.37,-1407.57"/>
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+<!-- e_31_target -->
+<g id="node81" class="node">
+<title>e_31_target</title>
+<ellipse fill="black" stroke="black" cx="44.62" cy="-934.97" rx="1.8" ry="1.8"/>
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+<!-- h2o_e -->
+<g id="node82" class="node">
+<title>h2o_e</title>
+<ellipse fill="none" stroke="black" cx="313.99" cy="-1001.71" rx="18" ry="18"/>
+<text text-anchor="middle" x="313.99" y="-998.01" font-family="Times,serif" font-size="14.00">h2o_e</text>
+</g>
+<!-- h2o_e&#45;&gt;h2o_c -->
+<g id="edge200" class="edge">
+<title>h2o_e&#45;&gt;h2o_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.96" d="M331.21,-1007.15C395.49,-1027.47 621.74,-1098.97 700.05,-1123.72"/>
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+<!-- h2o_e&#45;&gt;e_31_target -->
+<g id="edge110" class="edge">
+<title>h2o_e&#45;&gt;e_31_target</title>
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+</g>
+<!-- e_33_target -->
+<g id="node84" class="node">
+<title>e_33_target</title>
+<ellipse fill="black" stroke="black" cx="1568.27" cy="-1997.95" rx="1.8" ry="1.8"/>
+</g>
+<!-- mal__L_e -->
+<g id="node85" class="node">
+<title>mal__L_e</title>
+<ellipse fill="none" stroke="black" cx="1379.92" cy="-1814.92" rx="18" ry="18"/>
+<text text-anchor="middle" x="1379.92" y="-1811.22" font-family="Times,serif" font-size="14.00">mal__L_e</text>
+</g>
+<!-- mal__L_e&#45;&gt;e_33_target -->
+<g id="edge112" class="edge">
+<title>mal__L_e&#45;&gt;e_33_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1392.86,-1827.5C1428.71,-1862.33 1528.61,-1959.41 1559.23,-1989.17"/>
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+<!-- mal__L_e&#45;&gt;e_62_center -->
+<g id="edge221" class="edge">
+<title>mal__L_e&#45;&gt;e_62_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1367,-1802.17C1318.75,-1754.54 1150.46,-1588.44 1123.17,-1561.51"/>
+</g>
+<!-- e_34_target -->
+<g id="node86" class="node">
+<title>e_34_target</title>
+<ellipse fill="black" stroke="black" cx="1865.81" cy="-666.02" rx="1.8" ry="1.8"/>
+</g>
+<!-- nh4_e -->
+<g id="node87" class="node">
+<title>nh4_e</title>
+<ellipse fill="none" stroke="black" cx="1628.87" cy="-770.95" rx="18" ry="18"/>
+<text text-anchor="middle" x="1628.87" y="-767.25" font-family="Times,serif" font-size="14.00">nh4_e</text>
+</g>
+<!-- nh4_e&#45;&gt;e_34_target -->
+<g id="edge113" class="edge">
+<title>nh4_e&#45;&gt;e_34_target</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.65" d="M1645.53,-763.57C1690.96,-743.45 1816.13,-688.02 1854.49,-671.03"/>
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+<!-- nh4_c -->
+<g id="node114" class="node">
+<title>nh4_c</title>
+<ellipse fill="none" stroke="black" cx="1259.89" cy="-927.4" rx="18" ry="18"/>
+<text text-anchor="middle" x="1259.89" y="-923.7" font-family="Times,serif" font-size="14.00">nh4_c</text>
+</g>
+<!-- nh4_e&#45;&gt;nh4_c -->
+<g id="edge249" class="edge">
+<title>nh4_e&#45;&gt;nh4_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.65" d="M1612.06,-778.08C1553.47,-802.92 1357.99,-885.81 1286.43,-916.15"/>
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+<!-- e_35_target -->
+<g id="node88" class="node">
+<title>e_35_target</title>
+<ellipse fill="black" stroke="black" cx="299.66" cy="-2500.92" rx="1.8" ry="1.8"/>
+</g>
+<!-- o2_e -->
+<g id="node89" class="node">
+<title>o2_e</title>
+<ellipse fill="none" stroke="black" cx="405.25" cy="-2275.53" rx="18" ry="18"/>
+<text text-anchor="middle" x="405.25" y="-2271.83" font-family="Times,serif" font-size="14.00">o2_e</text>
+</g>
+<!-- o2_e&#45;&gt;o2_c -->
+<g id="edge250" class="edge">
+<title>o2_e&#45;&gt;o2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.98" d="M412.84,-2258.94C437.62,-2204.74 516.31,-2032.65 546.42,-1966.81"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.98" points="550.46,-1968.45 550.66,-1957.54 542.54,-1964.82 550.46,-1968.45"/>
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+<!-- o2_e&#45;&gt;e_35_target -->
+<g id="edge114" class="edge">
+<title>o2_e&#45;&gt;e_35_target</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.96" d="M397.49,-2292.11C377.04,-2335.76 322.09,-2453.05 304.89,-2489.77"/>
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+<!-- e_36_target -->
+<g id="node90" class="node">
+<title>e_36_target</title>
+<ellipse fill="black" stroke="black" cx="191.03" cy="-1872.16" rx="1.8" ry="1.8"/>
+</g>
+<!-- pi_e -->
+<g id="node91" class="node">
+<title>pi_e</title>
+<ellipse fill="none" stroke="black" cx="399.26" cy="-1694.73" rx="18" ry="18"/>
+<text text-anchor="middle" x="399.26" y="-1691.03" font-family="Times,serif" font-size="14.00">pi_e</text>
+</g>
+<!-- pi_e&#45;&gt;e_36_target -->
+<g id="edge115" class="edge">
+<title>pi_e&#45;&gt;e_36_target</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.04" d="M385.27,-1706.65C345.78,-1740.3 234.1,-1835.46 200.62,-1863.98"/>
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+<!-- pi_e&#45;&gt;e_77_center -->
+<g id="edge277" class="edge">
+<title>pi_e&#45;&gt;e_77_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.04" d="M412.85,-1682.62C464.74,-1636.37 648.88,-1472.27 677.33,-1446.92"/>
+</g>
+<!-- e_37_target -->
+<g id="node92" class="node">
+<title>e_37_target</title>
+<ellipse fill="black" stroke="black" cx="1.92" cy="-1481.45" rx="1.8" ry="1.8"/>
+</g>
+<!-- pyr_e -->
+<g id="node93" class="node">
+<title>pyr_e</title>
+<ellipse fill="none" stroke="black" cx="271.08" cy="-1416.72" rx="18" ry="18"/>
+<text text-anchor="middle" x="271.08" y="-1413.02" font-family="Times,serif" font-size="14.00">pyr_e</text>
+</g>
+<!-- pyr_e&#45;&gt;e_37_target -->
+<g id="edge116" class="edge">
+<title>pyr_e&#45;&gt;e_37_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M253.42,-1420.96C202.54,-1433.2 56.57,-1468.31 13.82,-1478.59"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="12.99,-1475.19 4.08,-1480.93 14.63,-1481.99 12.99,-1475.19"/>
+</g>
+<!-- pyr_e&#45;&gt;e_83_center -->
+<g id="edge307" class="edge">
+<title>pyr_e&#45;&gt;e_83_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M288.58,-1412.19C357.44,-1394.35 607.64,-1329.53 640.57,-1321"/>
+</g>
+<!-- e_38_target -->
+<g id="node94" class="node">
+<title>e_38_target</title>
+<ellipse fill="black" stroke="black" cx="867.98" cy="-2203.58" rx="1.8" ry="1.8"/>
+</g>
+<!-- succ_e -->
+<g id="node95" class="node">
+<title>succ_e</title>
+<ellipse fill="none" stroke="black" cx="880.7" cy="-1935.02" rx="18" ry="18"/>
+<text text-anchor="middle" x="880.7" y="-1931.32" font-family="Times,serif" font-size="14.00">succ_e</text>
+</g>
+<!-- succ_e&#45;&gt;e_38_target -->
+<g id="edge117" class="edge">
+<title>succ_e&#45;&gt;e_38_target</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M879.84,-1953.05C877.43,-2003.99 870.61,-2148.03 868.56,-2191.2"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="865.06,-2191.27 868.08,-2201.43 872.05,-2191.6 865.06,-2191.27"/>
+</g>
+<!-- succ_e&#45;&gt;e_86_center -->
+<g id="edge313" class="edge">
+<title>succ_e&#45;&gt;e_86_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M879.79,-1916.92C876.86,-1858.56 867.78,-1677.39 866.37,-1649.44"/>
+</g>
+<!-- fdp_c -->
+<g id="node96" class="node">
+<title>fdp_c</title>
+<ellipse fill="none" stroke="black" cx="837.15" cy="-608.74" rx="18" ry="18"/>
+<text text-anchor="middle" x="837.15" y="-605.04" font-family="Times,serif" font-size="14.00">fdp_c</text>
+</g>
+<!-- e_39_center -->
+<g id="node98" class="node">
+<title>e_39_center</title>
+<polygon fill="none" stroke="black" points="934.69,-385.26 927.69,-385.26 927.69,-378.26 934.69,-378.26 934.69,-385.26"/>
+</g>
+<!-- fdp_c&#45;&gt;e_39_center -->
+<g id="edge118" class="edge">
+<title>fdp_c&#45;&gt;e_39_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.34" d="M844.07,-592.05C863.83,-544.34 919.79,-409.28 929.69,-385.39"/>
+</g>
+<!-- fdp_c&#45;&gt;e_40_center -->
+<g id="edge122" class="edge">
+<title>fdp_c&#45;&gt;e_40_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M833.1,-626.48C828.2,-648.05 819.77,-685.58 813.03,-717.87 803.8,-762.13 793.58,-816.1 790.89,-830.41"/>
+</g>
+<!-- dhap_c -->
+<g id="node97" class="node">
+<title>dhap_c</title>
+<ellipse fill="none" stroke="black" cx="1017.71" cy="-277.36" rx="18" ry="18"/>
+<text text-anchor="middle" x="1017.71" y="-273.66" font-family="Times,serif" font-size="14.00">dhap_c</text>
+</g>
+<!-- dhap_c&#45;&gt;g3p_c -->
+<g id="edge349" class="edge">
+<title>dhap_c&#45;&gt;g3p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.34" d="M1017.94,-295.45C1018.56,-346.26 1020.35,-490.66 1021.11,-552.4"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.34" points="1017.61,-552.63 1021.24,-562.59 1024.61,-552.54 1017.61,-552.63"/>
+</g>
+<!-- e_39_center&#45;&gt;g3p_c -->
+<g id="edge120" class="edge">
+<title>e_39_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.34" d="M932.92,-385.56C942.33,-406.35 987.96,-507.04 1009.79,-555.2"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.34" points="1006.62,-556.69 1013.94,-564.36 1013,-553.8 1006.62,-556.69"/>
+</g>
+<!-- e_39_center&#45;&gt;dhap_c -->
+<g id="edge119" class="edge">
+<title>e_39_center&#45;&gt;dhap_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.34" d="M934.48,-377.8C945.01,-365.09 978.45,-324.74 999.6,-299.22"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.34" points="1002.31,-301.44 1005.99,-291.51 996.92,-296.97 1002.31,-301.44"/>
+</g>
+<!-- e_40_center&#45;&gt;pi_c -->
+<g id="edge124" class="edge">
+<title>e_40_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M789.55,-837.56C785.85,-857.98 767.74,-962.88 770.71,-1049.04 771.02,-1057.98 771.61,-1067.72 772.23,-1076.5"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="768.75,-1076.93 772.99,-1086.64 775.73,-1076.41 768.75,-1076.93"/>
+</g>
+<!-- e_40_center&#45;&gt;f6p_c -->
+<g id="edge123" class="edge">
+<title>e_40_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M792.97,-830.5C808.25,-810.98 882.95,-715.51 917.43,-671.46"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="920.35,-673.41 923.76,-663.37 914.84,-669.09 920.35,-673.41"/>
+</g>
+<!-- for_c -->
+<g id="node100" class="node">
+<title>for_c</title>
+<ellipse fill="none" stroke="black" cx="426.89" cy="-1463.4" rx="18" ry="18"/>
+<text text-anchor="middle" x="426.89" y="-1459.7" font-family="Times,serif" font-size="14.00">for_c</text>
+</g>
+<!-- for_c&#45;&gt;for_e -->
+<g id="edge129" class="edge">
+<title>for_c&#45;&gt;for_e</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M416.99,-1478.51C395.11,-1511.89 342.51,-1592.13 316.21,-1632.26"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="313.27,-1630.36 310.72,-1640.64 319.13,-1634.19 313.27,-1630.36"/>
+</g>
+<!-- e_41_center&#45;&gt;h_c -->
+<g id="edge128" class="edge">
+<title>e_41_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M624.03,-1518.86C651.49,-1498.91 825.15,-1372.77 888.41,-1326.83"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="890.54,-1329.6 896.57,-1320.9 886.42,-1323.94 890.54,-1329.6"/>
+</g>
+<!-- e_41_center&#45;&gt;for_c -->
+<g id="edge127" class="edge">
+<title>e_41_center&#45;&gt;for_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M616.66,-1520.42C596.75,-1514.44 501.37,-1485.78 453.88,-1471.51"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="454.83,-1468.14 444.25,-1468.61 452.82,-1474.84 454.83,-1468.14"/>
+</g>
+<!-- fum_c -->
+<g id="node102" class="node">
+<title>fum_c</title>
+<ellipse fill="none" stroke="black" cx="826.44" cy="-1778.39" rx="18" ry="18"/>
+<text text-anchor="middle" x="826.44" y="-1774.69" font-family="Times,serif" font-size="14.00">fum_c</text>
+</g>
+<!-- fum_c&#45;&gt;e_43_center -->
+<g id="edge131" class="edge">
+<title>fum_c&#45;&gt;e_43_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M812.15,-1789.34C786.69,-1808.84 734.82,-1848.57 720.74,-1859.36"/>
+</g>
+<!-- fum_c&#45;&gt;e_45_center -->
+<g id="edge139" class="edge">
+<title>fum_c&#45;&gt;e_45_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M825.09,-1760.43C820.48,-1699.33 805.58,-1501.7 803.39,-1472.7"/>
+</g>
+<!-- succ_c -->
+<g id="node103" class="node">
+<title>succ_c</title>
+<ellipse fill="none" stroke="black" cx="717.27" cy="-1656.99" rx="18" ry="18"/>
+<text text-anchor="middle" x="717.27" y="-1653.29" font-family="Times,serif" font-size="14.00">succ_c</text>
+</g>
+<!-- succ_c&#45;&gt;e_87_center -->
+<g id="edge318" class="edge">
+<title>succ_c&#45;&gt;e_87_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M735.49,-1656.71C764.56,-1656.22 823.22,-1654.99 872.89,-1652.5 880.11,-1652.14 888.53,-1651.49 893.28,-1651.1"/>
+</g>
+<!-- succ_c&#45;&gt;e_88_center -->
+<g id="edge322" class="edge">
+<title>succ_c&#45;&gt;e_88_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M720.66,-1674.8C729.74,-1722.61 754.27,-1851.7 758.79,-1875.49"/>
+</g>
+<!-- succ_c&#45;&gt;e_89_center -->
+<g id="edge327" class="edge">
+<title>succ_c&#45;&gt;e_89_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.74" d="M718.63,-1638.82C723.69,-1571.27 741.26,-1336.88 743.7,-1304.25"/>
+</g>
+<!-- e_43_center&#45;&gt;q8_c -->
+<g id="edge132" class="edge">
+<title>e_43_center&#45;&gt;q8_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M720.76,-1858.36C733.36,-1845.3 776.5,-1800.68 812.72,-1764.4 816.86,-1760.25 821.32,-1755.84 825.58,-1751.64"/>
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+</g>
+<!-- e_43_center&#45;&gt;succ_c -->
+<g id="edge133" class="edge">
+<title>e_43_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M717.14,-1858.56C717.15,-1838.24 717.22,-1736.05 717.25,-1685.45"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="720.75,-1685.21 717.26,-1675.2 713.75,-1685.2 720.75,-1685.21"/>
+</g>
+<!-- e_44_center&#45;&gt;pyr_c -->
+<g id="edge137" class="edge">
+<title>e_44_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M735.87,-600.28C740.88,-632.97 777,-868.68 789.53,-950.49"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="786.1,-951.19 791.07,-960.55 793.02,-950.13 786.1,-951.19"/>
+</g>
+<!-- e_44_center&#45;&gt;f6p_c -->
+<g id="edge136" class="edge">
+<title>e_44_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M739.14,-597.85C752.53,-602.5 798.42,-618.2 837.12,-628.34 860.61,-634.49 887.62,-640.12 907.3,-643.96"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="906.65,-647.4 917.14,-645.85 907.98,-640.53 906.65,-647.4"/>
+</g>
+<!-- mal__L_c -->
+<g id="node106" class="node">
+<title>mal__L_c</title>
+<ellipse fill="none" stroke="black" cx="977.94" cy="-1337.39" rx="18" ry="18"/>
+<text text-anchor="middle" x="977.94" y="-1333.69" font-family="Times,serif" font-size="14.00">mal__L_c</text>
+</g>
+<!-- mal__L_c&#45;&gt;e_63_center -->
+<g id="edge224" class="edge">
+<title>mal__L_c&#45;&gt;e_63_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M973.32,-1319.85C966.03,-1292.09 952.26,-1239.72 948.53,-1225.54"/>
+</g>
+<!-- mal__L_c&#45;&gt;e_64_center -->
+<g id="edge229" class="edge">
+<title>mal__L_c&#45;&gt;e_64_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M979.24,-1319.2C981.57,-1287 986.68,-1217.85 991.77,-1159.54 993.4,-1140.77 995.67,-1118.32 996.56,-1109.68"/>
+</g>
+<!-- mal__L_c&#45;&gt;e_65_center -->
+<g id="edge234" class="edge">
+<title>mal__L_c&#45;&gt;e_65_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M979.62,-1319.39C981.4,-1301.82 984.59,-1274.36 989.06,-1250.85 1003.5,-1174.8 1030.21,-1083.82 1035.88,-1064.83"/>
+</g>
+<!-- e_45_center&#45;&gt;mal__L_c -->
+<g id="edge140" class="edge">
+<title>e_45_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M806.78,-1466.39C825.68,-1452.14 913.18,-1386.19 955.24,-1354.5"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.74" points="957.6,-1357.1 963.48,-1348.28 953.39,-1351.51 957.6,-1357.1"/>
+</g>
+<!-- e_46_center&#45;&gt;h_c -->
+<g id="edge143" class="edge">
+<title>e_46_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1004.87,-1695.25C997.65,-1670.03 954.43,-1517.94 926.62,-1392.38 922.66,-1374.52 918.92,-1354.32 916.14,-1338.41"/>
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+</g>
+<!-- e_46_center&#45;&gt;fum_c -->
+<g id="edge144" class="edge">
+<title>e_46_center&#45;&gt;fum_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1002.17,-1700.53C983.12,-1708.97 896.25,-1747.46 852.21,-1766.98"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="850.72,-1763.81 843,-1771.06 853.56,-1770.21 850.72,-1763.81"/>
+</g>
+<!-- 6pgl_c -->
+<g id="node109" class="node">
+<title>6pgl_c</title>
+<ellipse fill="none" stroke="black" cx="1228.21" cy="-853.67" rx="18" ry="18"/>
+<text text-anchor="middle" x="1228.21" y="-849.97" font-family="Times,serif" font-size="14.00">6pgl_c</text>
+</g>
+<!-- 6pgl_c&#45;&gt;e_75_center -->
+<g id="edge271" class="edge">
+<title>6pgl_c&#45;&gt;e_75_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1218.24,-869.01C1203.41,-891.47 1174.23,-934.32 1145.99,-968.09 1123.44,-995.06 1092.72,-1024.37 1082.41,-1034.04"/>
+</g>
+<!-- e_47_center&#45;&gt;h_c -->
+<g id="edge148" class="edge">
+<title>e_47_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1067.48,-971.03C1062.11,-982.99 1044.57,-1022.11 1030.26,-1054.55 996.19,-1131.78 990.83,-1152.53 954.28,-1228.62 945.05,-1247.83 933.8,-1269.14 925.15,-1285.14"/>
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+</g>
+<!-- e_47_center&#45;&gt;nadph_c -->
+<g id="edge149" class="edge">
+<title>e_47_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1073.03,-969.38C1083.5,-974.76 1112.9,-989.86 1134.63,-1001.01"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.71" points="1133.19,-1004.21 1143.69,-1005.67 1136.39,-997.98 1133.19,-1004.21"/>
+</g>
+<!-- e_47_center&#45;&gt;6pgl_c -->
+<g id="edge147" class="edge">
+<title>e_47_center&#45;&gt;6pgl_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1072.74,-964.79C1090.13,-952.36 1165.77,-898.3 1204.77,-870.43"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.71" points="1207.29,-872.93 1213.39,-864.26 1203.22,-867.23 1207.29,-872.93"/>
+</g>
+<!-- 13dpg_c -->
+<g id="node111" class="node">
+<title>13dpg_c</title>
+<ellipse fill="none" stroke="black" cx="832.63" cy="-717.99" rx="18" ry="18"/>
+<text text-anchor="middle" x="832.63" y="-714.29" font-family="Times,serif" font-size="14.00">13dpg_c</text>
+</g>
+<!-- e_48_center&#45;&gt;nadh_c -->
+<g id="edge154" class="edge">
+<title>e_48_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.51" d="M975.74,-955.83C982.53,-979.45 1021.69,-1115.59 1038.64,-1174.51"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.51" points="1034.89,-1175.72 1041.44,-1184.24 1042.47,-1173.54 1034.89,-1175.72"/>
+</g>
+<!-- e_48_center&#45;&gt;h_c -->
+<g id="edge155" class="edge">
+<title>e_48_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.51" d="M973.51,-955.98C969.78,-967.38 958.4,-1003.15 951.94,-1033.52 932.8,-1123.52 919.78,-1231.92 914.32,-1282.1"/>
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+<!-- e_48_center&#45;&gt;13dpg_c -->
+<g id="edge153" class="edge">
+<title>e_48_center&#45;&gt;13dpg_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="4.51" d="M972.49,-948.62C958.31,-925.23 880.27,-796.54 847.32,-742.21"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="4.51" points="850.63,-740.06 842.08,-733.56 843.89,-744.15 850.63,-740.06"/>
+</g>
+<!-- e_49_center&#45;&gt;pyr_c -->
+<g id="edge159" class="edge">
+<title>e_49_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.78" d="M681.06,-637.83C683.45,-658.49 696.92,-764.21 731.02,-842.8 747.76,-881.37 768.47,-925.45 781.41,-952.6"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.78" points="778.34,-954.28 785.81,-961.79 784.65,-951.26 778.34,-954.28"/>
+</g>
+<!-- e_49_center&#45;&gt;g6p_c -->
+<g id="edge158" class="edge">
+<title>e_49_center&#45;&gt;g6p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.78" d="M684.32,-635.69C702.22,-642.78 782.36,-674.76 846.58,-704.21 862.83,-711.67 880.8,-720.58 894.93,-727.74"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.78" points="893.54,-730.96 904.04,-732.38 896.72,-724.72 893.54,-730.96"/>
+</g>
+<!-- nh4_c&#45;&gt;e_50_center -->
+<g id="edge162" class="edge">
+<title>nh4_c&#45;&gt;e_50_center</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.55" d="M1242.83,-933.79C1184.08,-955.79 992.13,-1027.68 962.5,-1038.78"/>
+</g>
+<!-- e_50_center&#45;&gt;h_c -->
+<g id="edge163" class="edge">
+<title>e_50_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.55" d="M957.97,-1044.04C953.47,-1069.78 927.36,-1218.95 916.33,-1282"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.55" points="912.85,-1281.58 914.58,-1292.04 919.75,-1282.79 912.85,-1281.58"/>
+</g>
+<!-- e_50_center&#45;&gt;adp_c -->
+<g id="edge166" class="edge">
+<title>e_50_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.55" d="M954.88,-1039.14C944.45,-1036.17 914.23,-1027.84 888.59,-1023.48 838.54,-1014.98 779.52,-1010.05 745.39,-1007.69"/>
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+</g>
+<!-- e_50_center&#45;&gt;pi_c -->
+<g id="edge164" class="edge">
+<title>e_50_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.55" d="M955.13,-1041.45C936.32,-1048.03 846.69,-1079.41 801.18,-1095.34"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.55" points="799.95,-1092.06 791.67,-1098.67 802.26,-1098.67 799.95,-1092.06"/>
+</g>
+<!-- e_50_center&#45;&gt;gln__L_c -->
+<g id="edge165" class="edge">
+<title>e_50_center&#45;&gt;gln__L_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.55" d="M955.1,-1037.2C945.36,-1028.89 917.55,-1005.16 897.73,-988.25"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.55" points="899.94,-985.53 890.06,-981.7 895.4,-990.86 899.94,-985.53"/>
+</g>
+<!-- e_51_center&#45;&gt;h_c -->
+<g id="edge170" class="edge">
+<title>e_51_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M626.98,-1045.51C637.61,-1059.57 676.13,-1109.64 713.1,-1146.07 772.33,-1204.43 850.23,-1264.62 888.37,-1293.15"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="886.63,-1296.22 896.74,-1299.38 890.81,-1290.6 886.63,-1296.22"/>
+</g>
+<!-- e_51_center&#45;&gt;adp_c -->
+<g id="edge173" class="edge">
+<title>e_51_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M627.64,-1041.08C635.57,-1039.61 655.44,-1035.59 671.21,-1029.58 678.19,-1026.93 685.49,-1023.5 692.15,-1020.08"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="694.19,-1022.96 701.37,-1015.17 690.89,-1016.78 694.19,-1022.96"/>
+</g>
+<!-- e_51_center&#45;&gt;pi_c -->
+<g id="edge171" class="edge">
+<title>e_51_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M627.85,-1043.26C644.25,-1050.13 711,-1078.06 748.56,-1093.78"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="747.29,-1097.04 757.87,-1097.68 750,-1090.59 747.29,-1097.04"/>
+</g>
+<!-- e_51_center&#45;&gt;gln__L_c -->
+<g id="edge172" class="edge">
+<title>e_51_center&#45;&gt;gln__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M627.72,-1041.3C640.2,-1039.83 682.81,-1034.44 717.05,-1025.55 764.87,-1013.13 818.83,-992.92 850.06,-980.59"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="851.37,-983.84 859.36,-976.88 848.78,-977.33 851.37,-983.84"/>
+</g>
+<!-- e_52_center&#45;&gt;h_c -->
+<g id="edge179" class="edge">
+<title>e_52_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.57" d="M1052.46,-1101.88C1045.24,-1112.84 1023.48,-1145.78 1005.17,-1172.94 978.22,-1212.9 946.5,-1259.15 927.73,-1286.44"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.57" points="924.67,-1284.71 921.88,-1294.93 930.43,-1288.68 924.67,-1284.71"/>
+</g>
+<!-- e_52_center&#45;&gt;akg_c -->
+<g id="edge180" class="edge">
+<title>e_52_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.57" d="M1058.66,-1101.19C1071.86,-1112 1117.1,-1149.05 1144.73,-1171.68"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.57" points="1142.73,-1174.57 1152.68,-1178.2 1147.16,-1169.16 1142.73,-1174.57"/>
+</g>
+<!-- e_52_center&#45;&gt;nadph_c -->
+<g id="edge178" class="edge">
+<title>e_52_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.57" d="M1058.92,-1094.94C1071.65,-1084.75 1111.96,-1052.48 1137.66,-1031.91"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.57" points="1140.13,-1034.41 1145.75,-1025.43 1135.76,-1028.95 1140.13,-1034.41"/>
+</g>
+<!-- e_52_center&#45;&gt;nh4_c -->
+<g id="edge177" class="edge">
+<title>e_52_center&#45;&gt;nh4_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.57" d="M1057.79,-1094.44C1068.46,-1080.83 1107.27,-1032.56 1146.2,-1000.1 1174.63,-976.39 1211.28,-954.25 1235.17,-940.78"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.57" points="1236.92,-943.81 1243.96,-935.89 1233.52,-937.69 1236.92,-943.81"/>
+</g>
+<!-- e_53_center&#45;&gt;glu__L_c -->
+<g id="edge184" class="edge">
+<title>e_53_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1025.83,-977.02C1035.89,-984.95 1064.66,-1008.22 1085.57,-1030.63 1103.67,-1050.03 1121.96,-1074.13 1134.57,-1091.62"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1131.96,-1093.99 1140.61,-1100.11 1137.66,-1089.93 1131.96,-1093.99"/>
+</g>
+<!-- e_53_center&#45;&gt;nh4_c -->
+<g id="edge183" class="edge">
+<title>e_53_center&#45;&gt;nh4_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1025.88,-972.39C1039.57,-965.9 1088.92,-943.38 1132.34,-934.55 1165.81,-927.74 1205.17,-926.54 1231.22,-926.66"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1231.47,-930.16 1241.51,-926.78 1231.55,-923.16 1231.47,-930.16"/>
+</g>
+<!-- e_54_center&#45;&gt;glu__L_c -->
+<g id="edge190" class="edge">
+<title>e_54_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1093.66,-1113.59C1099.42,-1113.75 1111.19,-1114.06 1122.57,-1114.36"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1122.63,-1117.87 1132.72,-1114.63 1122.82,-1110.87 1122.63,-1117.87"/>
+</g>
+<!-- e_54_center&#45;&gt;nadp_c -->
+<g id="edge189" class="edge">
+<title>e_54_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1093.96,-1111.62C1105.95,-1105.88 1142.76,-1088.28 1168.1,-1076.16"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1169.67,-1079.29 1177.18,-1071.82 1166.65,-1072.98 1169.67,-1079.29"/>
+</g>
+<!-- e_55_center&#45;&gt;h_c -->
+<g id="edge193" class="edge">
+<title>e_55_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1209.02,-1404.47C1187.29,-1394.02 1075.36,-1341.38 977.98,-1317.79 965.6,-1314.79 951.63,-1312.96 939.7,-1311.83"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="939.67,-1308.32 929.42,-1310.99 939.1,-1315.3 939.67,-1308.32"/>
+</g>
+<!-- e_55_center&#45;&gt;glu__L_c -->
+<g id="edge194" class="edge">
+<title>e_55_center&#45;&gt;glu__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1212.7,-1402.65C1212.14,-1381.69 1208.27,-1274.19 1186.45,-1189.95 1184.78,-1183.49 1183.53,-1182.13 1180.81,-1176.05 1175.49,-1164.15 1169.19,-1151.17 1163.75,-1140.25"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1166.85,-1138.63 1159.24,-1131.27 1160.6,-1141.77 1166.85,-1138.63"/>
+</g>
+<!-- 6pgc_c -->
+<g id="node121" class="node">
+<title>6pgc_c</title>
+<ellipse fill="none" stroke="black" cx="1357.1" cy="-922.35" rx="18" ry="18"/>
+<text text-anchor="middle" x="1357.1" y="-918.65" font-family="Times,serif" font-size="14.00">6pgc_c</text>
+</g>
+<!-- 6pgc_c&#45;&gt;e_56_center -->
+<g id="edge196" class="edge">
+<title>6pgc_c&#45;&gt;e_56_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1348.22,-906.39C1335.34,-883.24 1312.24,-841.72 1305.33,-829.31"/>
+</g>
+<!-- xu5p__D_c -->
+<g id="node147" class="node">
+<title>xu5p__D_c</title>
+<ellipse fill="none" stroke="black" cx="1309.8" cy="-319.98" rx="18" ry="18"/>
+<text text-anchor="middle" x="1309.8" y="-316.28" font-family="Times,serif" font-size="14.00">xu5p__D_c</text>
+</g>
+<!-- ru5p__D_c&#45;&gt;xu5p__D_c -->
+<g id="edge311" class="edge">
+<title>ru5p__D_c&#45;&gt;xu5p__D_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.76" d="M1358.64,-524.38C1349.4,-485.68 1327.42,-393.7 1316.38,-347.48"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.76" points="1319.73,-346.47 1314,-337.56 1312.92,-348.1 1319.73,-346.47"/>
+</g>
+<!-- e_56_center&#45;&gt;co2_c -->
+<g id="edge198" class="edge">
+<title>e_56_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1299.76,-828.4C1281.3,-842.25 1196.02,-906.26 1154.73,-937.25"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.71" points="1152.53,-934.53 1146.63,-943.33 1156.73,-940.13 1152.53,-934.53"/>
+</g>
+<!-- e_56_center&#45;&gt;nadph_c -->
+<g id="edge199" class="edge">
+<title>e_56_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1300.6,-829.31C1285.47,-849.19 1211.46,-946.41 1177.31,-991.27"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.71" points="1174.31,-989.43 1171.04,-999.5 1179.88,-993.67 1174.31,-989.43"/>
+</g>
+<!-- e_56_center&#45;&gt;ru5p__D_c -->
+<g id="edge197" class="edge">
+<title>e_56_center&#45;&gt;ru5p__D_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1304.09,-822.13C1309.55,-796.14 1343.24,-635.78 1357.03,-570.14"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.71" points="1360.5,-570.61 1359.14,-560.1 1353.65,-569.17 1360.5,-570.61"/>
+</g>
+<!-- e_58_center&#45;&gt;akg_c -->
+<g id="edge205" class="edge">
+<title>e_58_center&#45;&gt;akg_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M1002.21,-1165.5C1015.25,-1163.07 1059.76,-1155.75 1095.81,-1161.76 1111.55,-1164.38 1128.19,-1170.73 1141.4,-1176.73"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3" points="1140.24,-1180.05 1150.77,-1181.18 1143.24,-1173.73 1140.24,-1180.05"/>
+</g>
+<!-- e_58_center&#45;&gt;co2_c -->
+<g id="edge203" class="edge">
+<title>e_58_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M1000.85,-1162.43C1007.84,-1151.3 1029.01,-1117.96 1048.23,-1091.44 1063.97,-1069.72 1071.03,-1066.56 1085.57,-1044.03 1098.98,-1023.24 1111.74,-998.15 1120.51,-979.77"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3" points="1123.75,-981.11 1124.84,-970.57 1117.42,-978.13 1123.75,-981.11"/>
+</g>
+<!-- e_58_center&#45;&gt;nadph_c -->
+<g id="edge204" class="edge">
+<title>e_58_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3" d="M1002.14,-1162.77C1020.21,-1145.75 1100.21,-1070.36 1138.9,-1033.91"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3" points="1141.61,-1036.16 1146.49,-1026.75 1136.81,-1031.06 1141.61,-1036.16"/>
+</g>
+<!-- glx_c -->
+<g id="node125" class="node">
+<title>glx_c</title>
+<ellipse fill="none" stroke="black" cx="518.83" cy="-1516.48" rx="18" ry="18"/>
+<text text-anchor="middle" x="518.83" y="-1512.78" font-family="Times,serif" font-size="14.00">glx_c</text>
+</g>
+<!-- glx_c&#45;&gt;e_61_center -->
+<g id="edge216" class="edge">
+<title>glx_c&#45;&gt;e_61_center</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M533.35,-1505.72C579.82,-1471.32 723.22,-1365.14 747.52,-1347.15"/>
+</g>
+<!-- e_59_center&#45;&gt;succ_c -->
+<g id="edge208" class="edge">
+<title>e_59_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M543.26,-1615.01C561.86,-1619.5 645.75,-1639.73 689.9,-1650.39"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="689.16,-1653.81 699.7,-1652.75 690.8,-1647 689.16,-1653.81"/>
+</g>
+<!-- e_59_center&#45;&gt;glx_c -->
+<g id="edge207" class="edge">
+<title>e_59_center&#45;&gt;glx_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M538.76,-1610.41C536.48,-1599.67 529.72,-1567.79 524.7,-1544.14"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="528.1,-1543.33 522.6,-1534.27 521.26,-1544.78 528.1,-1543.33"/>
+</g>
+<!-- e_60_center&#45;&gt;nadh_c -->
+<g id="edge211" class="edge">
+<title>e_60_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M999.09,-1253.88C1004.74,-1247.65 1016.64,-1234.54 1027.09,-1223.02"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1029.88,-1225.16 1034.01,-1215.4 1024.7,-1220.45 1029.88,-1225.16"/>
+</g>
+<!-- e_60_center&#45;&gt;h_c -->
+<g id="edge213" class="edge">
+<title>e_60_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M992.14,-1259.81C982.51,-1265.81 955.67,-1282.53 935.56,-1295.07"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="933.52,-1292.21 926.88,-1300.47 937.22,-1298.16 933.52,-1292.21"/>
+</g>
+<!-- e_60_center&#45;&gt;pyr_c -->
+<g id="edge212" class="edge">
+<title>e_60_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M993.21,-1254.02C974.23,-1227.79 854.7,-1062.55 810.34,-1001.23"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="813.06,-999.02 804.36,-992.97 807.39,-1003.12 813.06,-999.02"/>
+</g>
+<!-- e_61_center&#45;&gt;coa_c -->
+<g id="edge218" class="edge">
+<title>e_61_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M753.79,-1340.92C765.4,-1325.65 811,-1265.7 836.47,-1232.22"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="839.51,-1234 842.78,-1223.92 833.94,-1229.76 839.51,-1234"/>
+</g>
+<!-- e_61_center&#45;&gt;h_c -->
+<g id="edge219" class="edge">
+<title>e_61_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M754.69,-1343.76C771.64,-1340.12 843.52,-1324.69 883.79,-1316.04"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="884.73,-1319.42 893.77,-1313.9 883.26,-1312.58 884.73,-1319.42"/>
+</g>
+<!-- e_61_center&#45;&gt;mal__L_c -->
+<g id="edge217" class="edge">
+<title>e_61_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M754.6,-1344.43C776.59,-1343.74 894.66,-1340.02 949.68,-1338.28"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="949.91,-1341.78 959.8,-1337.96 949.69,-1334.78 949.91,-1341.78"/>
+</g>
+<!-- e_62_center&#45;&gt;h_c -->
+<g id="edge223" class="edge">
+<title>e_62_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1116.48,-1554.31C1096.14,-1530.09 975.83,-1386.82 929.55,-1331.71"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="932.14,-1329.35 923.03,-1323.94 926.78,-1333.85 932.14,-1329.35"/>
+</g>
+<!-- e_62_center&#45;&gt;mal__L_c -->
+<g id="edge222" class="edge">
+<title>e_62_center&#45;&gt;mal__L_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1116.97,-1553.98C1102.32,-1531.17 1026.05,-1412.35 993.11,-1361.04"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="996.02,-1359.08 987.67,-1352.56 990.13,-1362.86 996.02,-1359.08"/>
+</g>
+<!-- e_63_center&#45;&gt;nadh_c -->
+<g id="edge226" class="edge">
+<title>e_63_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M951.33,-1221.15C962.21,-1218.92 994.49,-1212.32 1018.45,-1207.41"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.74" points="1019.35,-1210.8 1028.44,-1205.37 1017.94,-1203.94 1019.35,-1210.8"/>
+</g>
+<!-- e_63_center&#45;&gt;h_c -->
+<g id="edge227" class="edge">
+<title>e_63_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M946.02,-1225.71C941.96,-1235.62 930.75,-1262.96 922.18,-1283.86"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.74" points="918.9,-1282.63 918.34,-1293.21 925.38,-1285.29 918.9,-1282.63"/>
+</g>
+<!-- e_63_center&#45;&gt;oaa_c -->
+<g id="edge228" class="edge">
+<title>e_63_center&#45;&gt;oaa_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M944.9,-1218.3C931.95,-1200.78 875.3,-1124.17 846.61,-1085.38"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.74" points="849.38,-1083.23 840.62,-1077.27 843.75,-1087.39 849.38,-1083.23"/>
+</g>
+<!-- e_64_center&#45;&gt;nadh_c -->
+<g id="edge232" class="edge">
+<title>e_64_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M998.81,-1109.69C1004.4,-1120.48 1021.28,-1153.07 1033.36,-1176.39"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1030.33,-1178.15 1038.04,-1185.42 1036.54,-1174.93 1030.33,-1178.15"/>
+</g>
+<!-- e_64_center&#45;&gt;co2_c -->
+<g id="edge231" class="edge">
+<title>e_64_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M998.94,-1102.37C1003.78,-1093.65 1016.67,-1071.23 1030.26,-1054.55 1055.45,-1023.64 1089.13,-992.03 1110.75,-972.74"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1113.23,-975.22 1118.4,-965.98 1108.59,-969.97 1113.23,-975.22"/>
+</g>
+<!-- e_64_center&#45;&gt;pyr_c -->
+<g id="edge233" class="edge">
+<title>e_64_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M993.1,-1105.05C985.21,-1102.9 966.69,-1097.46 952.36,-1090.12 899.99,-1063.27 845.23,-1021.01 815.75,-996.88"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="817.73,-993.97 807.79,-990.3 813.27,-999.37 817.73,-993.97"/>
+</g>
+<!-- e_65_center&#45;&gt;co2_c -->
+<g id="edge236" class="edge">
+<title>e_65_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1040.13,-1057.69C1051.36,-1045.06 1089.87,-1001.76 1113.38,-975.32"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1116.12,-977.51 1120.15,-967.71 1110.89,-972.86 1116.12,-977.51"/>
+</g>
+<!-- e_65_center&#45;&gt;nadph_c -->
+<g id="edge238" class="edge">
+<title>e_65_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1040.52,-1060.05C1048.57,-1057.31 1068.82,-1050.37 1085.57,-1044.03 1101.61,-1037.96 1119.43,-1030.79 1133.61,-1024.98"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1135.3,-1028.07 1143.22,-1021.03 1132.64,-1021.6 1135.3,-1028.07"/>
+</g>
+<!-- e_65_center&#45;&gt;pyr_c -->
+<g id="edge237" class="edge">
+<title>e_65_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1033.41,-1059.79C1023.02,-1055.54 991.73,-1042.87 965.34,-1033.52 914.83,-1015.64 855.12,-997 821.13,-986.62"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="822.04,-983.23 811.45,-983.67 820,-989.93 822.04,-983.23"/>
+</g>
+<!-- e_66_center&#45;&gt;nad_c -->
+<g id="edge244" class="edge">
+<title>e_66_center&#45;&gt;nad_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M967.24,-1471.83C977.18,-1448.53 1032.41,-1319.38 1079.78,-1215.14 1080.98,-1212.48 1082.26,-1209.71 1083.54,-1206.96"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="1087.54,-1208.72 1087.82,-1197.81 1079.62,-1205.01 1087.54,-1208.72"/>
+</g>
+<!-- e_66_center&#45;&gt;h_e -->
+<g id="edge243" class="edge">
+<title>e_66_center&#45;&gt;h_e</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M961.93,-1478.64C957.13,-1482.64 948.44,-1489.9 940.05,-1496.91"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="937.1,-1493.67 932.23,-1503.43 942.71,-1500.39 937.1,-1493.67"/>
+</g>
+<!-- e_66_center&#45;&gt;q8h2_c -->
+<g id="edge242" class="edge">
+<title>e_66_center&#45;&gt;q8h2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="5" d="M963.42,-1479.2C958.05,-1487.96 944.03,-1510.68 931.74,-1529.28 889.57,-1593.1 837.7,-1666.9 811.69,-1703.61"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="5" points="807.88,-1701.43 805.66,-1712.11 815.01,-1706.49 807.88,-1701.43"/>
+</g>
+<!-- e_67_center&#45;&gt;nadh_c -->
+<g id="edge248" class="edge">
+<title>e_67_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1274.88,-1136.09C1259.78,-1139.98 1199.83,-1155.96 1153.09,-1175.86 1127.42,-1186.79 1122.89,-1195.4 1095.54,-1200.96 1088.96,-1202.29 1081.79,-1202.87 1075.01,-1203.04"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1074.82,-1199.54 1064.81,-1203.01 1074.8,-1206.54 1074.82,-1199.54"/>
+</g>
+<!-- e_67_center&#45;&gt;nadp_c -->
+<g id="edge247" class="edge">
+<title>e_67_center&#45;&gt;nadp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1274.81,-1132.12C1264.71,-1123.65 1235.79,-1099.4 1215.34,-1082.25"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1217.35,-1079.37 1207.44,-1075.63 1212.85,-1084.73 1217.35,-1079.37"/>
+</g>
+<!-- e_70_center&#45;&gt;accoa_c -->
+<g id="edge254" class="edge">
+<title>e_70_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.67" d="M955.39,-1085.31C939.13,-1093.67 872.85,-1127.77 835.78,-1146.84"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.67" points="833.89,-1143.88 826.6,-1151.56 837.09,-1150.1 833.89,-1143.88"/>
+</g>
+<!-- e_70_center&#45;&gt;nadh_c -->
+<g id="edge256" class="edge">
+<title>e_70_center&#45;&gt;nadh_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.67" d="M961.77,-1087.09C971.89,-1100.78 1008,-1149.64 1029.66,-1178.95"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.67" points="1026.86,-1181.05 1035.62,-1187.01 1032.49,-1176.89 1026.86,-1181.05"/>
+</g>
+<!-- e_70_center&#45;&gt;co2_c -->
+<g id="edge255" class="edge">
+<title>e_70_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.67" d="M962.68,-1080.72C981.36,-1066.77 1067.65,-1002.35 1109.43,-971.16"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.67" points="1111.71,-973.82 1117.63,-965.04 1107.52,-968.21 1111.71,-973.82"/>
+</g>
+<!-- e_71_center&#45;&gt;h_c -->
+<g id="edge260" class="edge">
+<title>e_71_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.34" d="M839.5,-904.98C845.39,-938.16 891.12,-1195.77 906.43,-1282.06"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.34" points="903.03,-1282.92 908.23,-1292.16 909.92,-1281.7 903.03,-1282.92"/>
+</g>
+<!-- e_71_center&#45;&gt;adp_c -->
+<g id="edge261" class="edge">
+<title>e_71_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.34" d="M835.36,-904.46C821.39,-916.45 769.05,-961.37 738.89,-987.25"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.34" points="736.34,-984.83 731.03,-994 740.89,-990.14 736.34,-984.83"/>
+</g>
+<!-- e_71_center&#45;&gt;fdp_c -->
+<g id="edge259" class="edge">
+<title>e_71_center&#45;&gt;fdp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="3.34" d="M839.44,-897.71C842.26,-878.67 854.56,-790.52 852.23,-718.11 851.33,-690.12 846.55,-658.46 842.61,-636.43"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="3.34" points="846.02,-635.64 840.76,-626.45 839.14,-636.92 846.02,-635.64"/>
+</g>
+<!-- e_72_center&#45;&gt;accoa_c -->
+<g id="edge264" class="edge">
+<title>e_72_center&#45;&gt;accoa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M619.06,-1222.94C639.18,-1216.31 735.75,-1184.49 783.51,-1168.76"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="784.78,-1172.03 793.18,-1165.57 782.59,-1165.38 784.78,-1172.03"/>
+</g>
+<!-- e_72_center&#45;&gt;for_c -->
+<g id="edge265" class="edge">
+<title>e_72_center&#45;&gt;for_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M612.38,-1227.92C593.27,-1252.19 486.75,-1387.41 444.33,-1441.26"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="441.53,-1439.16 438.09,-1449.18 447.03,-1443.49 441.53,-1439.16"/>
+</g>
+<!-- e_74_center&#45;&gt;adp_c -->
+<g id="edge270" class="edge">
+<title>e_74_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.96" d="M665.82,-811.12C671.22,-831.61 697.1,-929.96 709.9,-978.6"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.96" points="706.57,-979.67 712.5,-988.45 713.34,-977.89 706.57,-979.67"/>
+</g>
+<!-- e_74_center&#45;&gt;13dpg_c -->
+<g id="edge269" class="edge">
+<title>e_74_center&#45;&gt;13dpg_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="3.96" d="M668.33,-805.47C686.01,-796.05 766.23,-753.34 807.67,-731.28"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="3.96" points="809.42,-734.31 816.6,-726.52 806.13,-728.13 809.42,-734.31"/>
+</g>
+<!-- e_75_center&#45;&gt;h_c -->
+<g id="edge273" class="edge">
+<title>e_75_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1076.75,-1040.98C1071.72,-1049.68 1058.7,-1072.31 1048.23,-1091.44 1028.57,-1127.38 1026.33,-1137.86 1005.17,-1172.94 980.27,-1214.21 947.93,-1260.05 928.47,-1286.91"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.71" points="925.45,-1285.11 922.39,-1295.26 931.11,-1289.23 925.45,-1285.11"/>
+</g>
+<!-- e_75_center&#45;&gt;6pgc_c -->
+<g id="edge274" class="edge">
+<title>e_75_center&#45;&gt;6pgc_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.71" d="M1082.44,-1035.15C1092.35,-1029.17 1121.14,-1012.08 1146.2,-1000.1 1210,-969.58 1289.16,-943.31 1329.96,-930.57"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.71" points="1331.19,-933.85 1339.71,-927.55 1329.12,-927.16 1331.19,-933.85"/>
+</g>
+<!-- e_77_center&#45;&gt;h_c -->
+<g id="edge279" class="edge">
+<title>e_77_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.04" d="M684.66,-1441.52C707.55,-1428.25 833.07,-1355.52 886.89,-1324.33"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.04" points="888.87,-1327.22 895.77,-1319.18 885.36,-1321.17 888.87,-1327.22"/>
+</g>
+<!-- e_77_center&#45;&gt;pi_c -->
+<g id="edge278" class="edge">
+<title>e_77_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.04" d="M682.09,-1439.81C690.45,-1409.51 746.4,-1206.71 766.98,-1132.12"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.04" points="770.46,-1132.65 769.75,-1122.08 763.71,-1130.79 770.46,-1132.65"/>
+</g>
+<!-- e_78_center&#45;&gt;h_c -->
+<g id="edge284" class="edge">
+<title>e_78_center&#45;&gt;h_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.66" d="M882.26,-1033.72C884.96,-1059.32 901.59,-1216.97 908.45,-1282.06"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.66" points="904.98,-1282.45 909.51,-1292.03 911.94,-1281.71 904.98,-1282.45"/>
+</g>
+<!-- e_78_center&#45;&gt;pi_c -->
+<g id="edge283" class="edge">
+<title>e_78_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.66" d="M879.77,-1033.84C874.62,-1042.44 860.62,-1064.14 843.61,-1076.65 831.15,-1085.81 815.27,-1092.52 801.88,-1097.07"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.66" points="800.69,-1093.78 792.22,-1100.14 802.81,-1100.45 800.69,-1093.78"/>
+</g>
+<!-- e_78_center&#45;&gt;oaa_c -->
+<g id="edge285" class="edge">
+<title>e_78_center&#45;&gt;oaa_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.66" d="M878.15,-1032.52C872.99,-1035.74 863.27,-1041.82 853.89,-1047.67"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.66" points="851.79,-1044.86 845.16,-1053.13 855.5,-1050.8 851.79,-1044.86"/>
+</g>
+<!-- e_79_center&#45;&gt;adp_c -->
+<g id="edge290" class="edge">
+<title>e_79_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M868.93,-895.04C852,-907.41 778.44,-961.14 740.28,-989.02"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="737.84,-986.47 731.83,-995.19 741.97,-992.12 737.84,-986.47"/>
+</g>
+<!-- e_79_center&#45;&gt;co2_c -->
+<g id="edge288" class="edge">
+<title>e_79_center&#45;&gt;co2_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M876.14,-893.32C900.8,-899.18 1043.22,-933.01 1104.35,-947.53"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1103.9,-951.02 1114.44,-949.93 1105.52,-944.21 1103.9,-951.02"/>
+</g>
+<!-- e_79_center&#45;&gt;pep_c -->
+<g id="edge289" class="edge">
+<title>e_79_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M868.79,-890.62C854.58,-883.56 802.49,-857.65 770.58,-841.78"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="771.9,-838.53 761.39,-837.21 768.79,-844.8 771.9,-838.53"/>
+</g>
+<!-- e_80_center&#45;&gt;h_c -->
+<g id="edge296" class="edge">
+<title>e_80_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M667.63,-1026.51C691.04,-1053.74 839.59,-1226.56 892.63,-1288.26"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="890.28,-1290.9 899.45,-1296.2 895.59,-1286.34 890.28,-1290.9"/>
+</g>
+<!-- e_80_center&#45;&gt;amp_c -->
+<g id="edge294" class="edge">
+<title>e_80_center&#45;&gt;amp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M660.77,-1020.33C636.84,-1003.98 504.47,-913.55 449.93,-876.28"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="451.81,-873.33 441.58,-870.58 447.86,-879.11 451.81,-873.33"/>
+</g>
+<!-- e_80_center&#45;&gt;pi_c -->
+<g id="edge297" class="edge">
+<title>e_80_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M667.94,-1026.53C675.06,-1034 692.15,-1051.38 708.37,-1063.76 721.5,-1073.78 737.19,-1083.56 750,-1091.04"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="748.32,-1094.12 758.74,-1096.06 751.81,-1088.05 748.32,-1094.12"/>
+</g>
+<!-- e_80_center&#45;&gt;pep_c -->
+<g id="edge295" class="edge">
+<title>e_80_center&#45;&gt;pep_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M666.05,-1019.18C674.39,-999.1 714.56,-902.33 734.17,-855.1"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="737.42,-856.39 738.02,-845.82 730.96,-853.71 737.42,-856.39"/>
+</g>
+<!-- e_81_center&#45;&gt;coa_c -->
+<g id="edge300" class="edge">
+<title>e_81_center&#45;&gt;coa_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M595.5,-1131.02C620.5,-1138.59 765.38,-1182.46 826.61,-1201.01"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="825.77,-1204.41 836.36,-1203.96 827.8,-1197.71 825.77,-1204.41"/>
+</g>
+<!-- e_81_center&#45;&gt;actp_c -->
+<g id="edge301" class="edge">
+<title>e_81_center&#45;&gt;actp_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M588.04,-1129.24C562.69,-1124.82 415.76,-1099.2 353.66,-1088.37"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="354.23,-1084.92 343.77,-1086.65 353.02,-1091.81 354.23,-1084.92"/>
+</g>
+<!-- e_82_center&#45;&gt;atp_c -->
+<g id="edge305" class="edge">
+<title>e_82_center&#45;&gt;atp_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.12" d="M773.8,-1042.84C768.87,-1043.53 759.6,-1044.81 750.27,-1046.11"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.12" points="749.74,-1042.65 740.32,-1047.49 750.7,-1049.58 749.74,-1042.65"/>
+</g>
+<!-- e_82_center&#45;&gt;pyr_c -->
+<g id="edge306" class="edge">
+<title>e_82_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="1.12" d="M778.39,-1038.53C780.04,-1032.08 783.53,-1018.47 786.77,-1005.82"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="1.12" points="790.18,-1006.6 789.28,-996.04 783.4,-1004.86 790.18,-1006.6"/>
+</g>
+<!-- e_83_center&#45;&gt;h_c -->
+<g id="edge310" class="edge">
+<title>e_83_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M647.93,-1319.93C673.31,-1318.98 819.84,-1313.53 882.74,-1311.18"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="883.26,-1314.67 893.12,-1310.8 883,-1307.67 883.26,-1314.67"/>
+</g>
+<!-- e_83_center&#45;&gt;pyr_c -->
+<g id="edge309" class="edge">
+<title>e_83_center&#45;&gt;pyr_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M645.05,-1316.35C650.03,-1295.8 675.64,-1194.37 713.12,-1118.36 733.74,-1076.54 761.6,-1030.01 778.6,-1002.52"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="781.61,-1004.3 783.92,-993.96 775.67,-1000.6 781.61,-1004.3"/>
+</g>
+<!-- xu5p__D_c&#45;&gt;e_92_center -->
+<g id="edge342" class="edge">
+<title>xu5p__D_c&#45;&gt;e_92_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.87" d="M1293.37,-327.64C1264.17,-341.26 1204.89,-368.92 1189.66,-376.02"/>
+</g>
+<!-- xu5p__D_c&#45;&gt;e_93_center -->
+<g id="edge346" class="edge">
+<title>xu5p__D_c&#45;&gt;e_93_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.51" d="M1294.8,-330.05C1254.9,-356.85 1147.74,-428.83 1126.38,-443.17"/>
+</g>
+<!-- e_86_center&#45;&gt;h_c -->
+<g id="edge316" class="edge">
+<title>e_86_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M866.7,-1642.03C870.72,-1612.17 897.55,-1413.02 907.61,-1338.33"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="911.1,-1338.63 908.97,-1328.25 904.17,-1337.7 911.1,-1338.63"/>
+</g>
+<!-- e_86_center&#45;&gt;succ_c -->
+<g id="edge315" class="edge">
+<title>e_86_center&#45;&gt;succ_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M862.51,-1646.08C846.65,-1647.27 783.28,-1652.03 745.68,-1654.85"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="745.08,-1651.39 735.38,-1655.63 745.61,-1658.37 745.08,-1651.39"/>
+</g>
+<!-- e_87_center&#45;&gt;h_c -->
+<g id="edge320" class="edge">
+<title>e_87_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M897,-1647C896.86,-1631.02 896.47,-1567.41 898.38,-1515.18 900.7,-1451.96 906.06,-1377.93 909.14,-1338.4"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="912.64,-1338.45 909.94,-1328.2 905.66,-1337.9 912.64,-1338.45"/>
+</g>
+<!-- e_87_center&#45;&gt;succ_e -->
+<g id="edge319" class="edge">
+<title>e_87_center&#45;&gt;succ_e</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M896.83,-1654.37C895.34,-1680.37 886.13,-1840.44 882.34,-1906.53"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="878.83,-1906.46 881.75,-1916.65 885.82,-1906.87 878.83,-1906.46"/>
+</g>
+<!-- e_88_center&#45;&gt;q8h2_c -->
+<g id="edge323" class="edge">
+<title>e_88_center&#45;&gt;q8h2_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M760.39,-1875.51C764.23,-1859.09 779.73,-1792.83 788.69,-1754.54"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.74" points="792.15,-1755.08 791.02,-1744.55 785.34,-1753.49 792.15,-1755.08"/>
+</g>
+<!-- e_88_center&#45;&gt;fum_c -->
+<g id="edge324" class="edge">
+<title>e_88_center&#45;&gt;fum_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="2.74" d="M762.05,-1875.45C769.92,-1863.59 794.33,-1826.79 810.74,-1802.07"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="2.74" points="813.76,-1803.84 816.37,-1793.58 807.93,-1799.97 813.76,-1803.84"/>
+</g>
+<!-- e_89_center&#45;&gt;adp_c -->
+<g id="edge330" class="edge">
+<title>e_89_center&#45;&gt;adp_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.74" d="M743.14,-1296.95C738.09,-1275.89 712.03,-1166.42 707.37,-1132.21 702.42,-1095.89 697.96,-1086.21 702.72,-1049.86 703.47,-1044.09 704.95,-1038.07 706.69,-1032.4"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.74" points="710.08,-1033.3 709.98,-1022.7 703.45,-1031.04 710.08,-1033.3"/>
+</g>
+<!-- e_89_center&#45;&gt;succoa_c -->
+<g id="edge329" class="edge">
+<title>e_89_center&#45;&gt;succoa_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.74" d="M747.49,-1302.06C767.81,-1311.3 871.11,-1358.27 920.22,-1380.6"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.74" points="919,-1383.89 929.55,-1384.85 921.9,-1377.52 919,-1383.89"/>
+</g>
+<!-- e_89_center&#45;&gt;pi_c -->
+<g id="edge328" class="edge">
+<title>e_89_center&#45;&gt;pi_c</title>
+<path fill="none" stroke="#8b1a1a" stroke-width="2.74" d="M744.57,-1296.73C747.7,-1276.68 762.65,-1180.92 770.18,-1132.63"/>
+<polygon fill="#8b1a1a" stroke="#8b1a1a" stroke-width="2.74" points="773.68,-1132.96 771.76,-1122.54 766.76,-1131.88 773.68,-1132.96"/>
+</g>
+<!-- s7p_c -->
+<g id="node152" class="node">
+<title>s7p_c</title>
+<ellipse fill="none" stroke="black" cx="1172.99" cy="-195.1" rx="18" ry="18"/>
+<text text-anchor="middle" x="1172.99" y="-191.4" font-family="Times,serif" font-size="14.00">s7p_c</text>
+</g>
+<!-- s7p_c&#45;&gt;e_90_center -->
+<g id="edge331" class="edge">
+<title>s7p_c&#45;&gt;e_90_center</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.87" d="M1164.48,-211.18C1140.95,-255.61 1076.03,-378.24 1064.06,-400.84"/>
+</g>
+<!-- e_90_center&#45;&gt;e4p_c -->
+<g id="edge334" class="edge">
+<title>e_90_center&#45;&gt;e4p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.87" d="M1062.3,-408.04C1063.17,-428.66 1067.53,-532.7 1069.66,-583.55"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="0.87" points="1066.17,-583.7 1070.08,-593.55 1073.16,-583.41 1066.17,-583.7"/>
+</g>
+<!-- e_90_center&#45;&gt;f6p_c -->
+<g id="edge333" class="edge">
+<title>e_90_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.87" d="M1060.15,-408.29C1047.45,-432.71 977.57,-567.08 948.07,-623.82"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="0.87" points="944.88,-622.36 943.37,-632.85 951.09,-625.59 944.88,-622.36"/>
+</g>
+<!-- e_91_center&#45;&gt;nad_c -->
+<g id="edge340" class="edge">
+<title>e_91_center&#45;&gt;nad_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1115.38,-1268.54C1113.09,-1258.41 1106.82,-1230.64 1101.96,-1209.14"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1105.33,-1208.17 1099.71,-1199.19 1098.5,-1209.72 1105.33,-1208.17"/>
+</g>
+<!-- e_91_center&#45;&gt;h_c -->
+<g id="edge339" class="edge">
+<title>e_91_center&#45;&gt;h_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1112.71,-1273.1C1092.33,-1276.85 989.44,-1295.77 939.16,-1305.01"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="938.48,-1301.58 929.27,-1306.83 939.74,-1308.46 938.48,-1301.58"/>
+</g>
+<!-- e_91_center&#45;&gt;nadph_c -->
+<g id="edge338" class="edge">
+<title>e_91_center&#45;&gt;nadph_c</title>
+<path fill="none" stroke="black" stroke-width="0.25" d="M1116.38,-1268.52C1116.96,-1250.67 1119.98,-1175.49 1131.34,-1115.06 1136.13,-1089.58 1144.44,-1061.23 1150.88,-1041.07"/>
+<polygon fill="black" stroke="black" stroke-width="0.25" points="1154.28,-1041.92 1154.04,-1031.33 1147.62,-1039.75 1154.28,-1041.92"/>
+</g>
+<!-- e_92_center&#45;&gt;g3p_c -->
+<g id="edge344" class="edge">
+<title>e_92_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.87" d="M1183.26,-381.5C1175.15,-392.54 1150.67,-425.67 1129.35,-452.38 1098.8,-490.64 1061.88,-534.06 1040.11,-559.39"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="0.87" points="1037.21,-557.39 1033.34,-567.25 1042.52,-561.96 1037.21,-557.39"/>
+</g>
+<!-- e_92_center&#45;&gt;s7p_c -->
+<g id="edge343" class="edge">
+<title>e_92_center&#45;&gt;s7p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.87" d="M1185.76,-373.9C1184.39,-354.79 1178.24,-268.59 1175,-223.23"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="0.87" points="1178.48,-222.88 1174.28,-213.16 1171.5,-223.38 1178.48,-222.88"/>
+</g>
+<!-- e_93_center&#45;&gt;g3p_c -->
+<g id="edge348" class="edge">
+<title>e_93_center&#45;&gt;g3p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.51" d="M1119.94,-449.3C1108.52,-464.57 1063.67,-524.52 1038.62,-558.01"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="0.51" points="1035.61,-556.2 1032.42,-566.31 1041.21,-560.4 1035.61,-556.2"/>
+</g>
+<!-- e_93_center&#45;&gt;f6p_c -->
+<g id="edge347" class="edge">
+<title>e_93_center&#45;&gt;f6p_c</title>
+<path fill="none" stroke="#104e8b" stroke-width="0.51" d="M1119.03,-449.41C1104.73,-464.16 1050.84,-519.93 1007.72,-566.98 989.02,-587.38 968.11,-611.07 953.51,-627.74"/>
+<polygon fill="#104e8b" stroke="#104e8b" stroke-width="0.51" points="950.83,-625.49 946.89,-635.32 956.11,-630.1 950.83,-625.49"/>
+</g>
+</g>
+</svg>
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diff --git a/main/_static/switcher.json b/main/_static/switcher.json
index c82c96ef..70481cd2 100644
--- a/main/_static/switcher.json
+++ b/main/_static/switcher.json
@@ -1,12 +1,12 @@
 [
     {
       "name": "latest (dev)",
-      "version": "dev",
+      "version": "1.0.0-alpha.0",
       "url": "https://saezlab.github.io/corneto/dev/"
     },
     {
       "name": "v1.0.0-alpha.0",
-      "version": "v1.0.0-alpha.0",
+      "version": "1.0.0-alpha.0",
       "url": "https://saezlab.github.io/corneto/main/"
     }
 ]
\ No newline at end of file
diff --git a/main/api/corneto.backend.html b/main/api/corneto.backend.html
index f1c97fbc..21ba7d5c 100644
--- a/main/api/corneto.backend.html
+++ b/main/api/corneto.backend.html
@@ -63,7 +63,7 @@
     <script>
         DOCUMENTATION_OPTIONS.theme_version = '0.15.2';
         DOCUMENTATION_OPTIONS.theme_switcher_json_url = 'https://saezlab.github.io/corneto/dev/_static/switcher.json';
-        DOCUMENTATION_OPTIONS.theme_switcher_version_match = 'dev';
+        DOCUMENTATION_OPTIONS.theme_switcher_version_match = '1.0.0-alpha.0';
         DOCUMENTATION_OPTIONS.show_version_warning_banner = false;
         </script>
     <link rel="index" title="Index" href="../genindex.html" />
diff --git a/main/api/corneto.html b/main/api/corneto.html
index ef437254..7d8645ac 100644
--- a/main/api/corneto.html
+++ b/main/api/corneto.html
@@ -63,7 +63,7 @@
     <script>
         DOCUMENTATION_OPTIONS.theme_version = '0.15.2';
         DOCUMENTATION_OPTIONS.theme_switcher_json_url = 'https://saezlab.github.io/corneto/dev/_static/switcher.json';
-        DOCUMENTATION_OPTIONS.theme_switcher_version_match = 'dev';
+        DOCUMENTATION_OPTIONS.theme_switcher_version_match = '1.0.0-alpha.0';
         DOCUMENTATION_OPTIONS.show_version_warning_banner = false;
         </script>
     <link rel="index" title="Index" href="../genindex.html" />
diff --git a/main/api/corneto.methods.html b/main/api/corneto.methods.html
index 4a17ce44..db84cdc5 100644
--- a/main/api/corneto.methods.html
+++ b/main/api/corneto.methods.html
@@ -63,7 +63,7 @@
     <script>
         DOCUMENTATION_OPTIONS.theme_version = '0.15.2';
         DOCUMENTATION_OPTIONS.theme_switcher_json_url = 'https://saezlab.github.io/corneto/dev/_static/switcher.json';
-        DOCUMENTATION_OPTIONS.theme_switcher_version_match = 'dev';
+        DOCUMENTATION_OPTIONS.theme_switcher_version_match = '1.0.0-alpha.0';
         DOCUMENTATION_OPTIONS.show_version_warning_banner = false;
         </script>
     <link rel="index" title="Index" href="../genindex.html" />
diff --git a/main/api/corneto.methods.metabolism.html b/main/api/corneto.methods.metabolism.html
index 39010a60..23b62efd 100644
--- a/main/api/corneto.methods.metabolism.html
+++ b/main/api/corneto.methods.metabolism.html
@@ -63,7 +63,7 @@
     <script>
         DOCUMENTATION_OPTIONS.theme_version = '0.15.2';
         DOCUMENTATION_OPTIONS.theme_switcher_json_url = 'https://saezlab.github.io/corneto/dev/_static/switcher.json';
-        DOCUMENTATION_OPTIONS.theme_switcher_version_match = 'dev';
+        DOCUMENTATION_OPTIONS.theme_switcher_version_match = '1.0.0-alpha.0';
         DOCUMENTATION_OPTIONS.show_version_warning_banner = false;
         </script>
     <link rel="index" title="Index" href="../genindex.html" />
diff --git a/main/api/corneto.utils.html b/main/api/corneto.utils.html
index d3b76ac6..6a35a695 100644
--- a/main/api/corneto.utils.html
+++ b/main/api/corneto.utils.html
@@ -63,7 +63,7 @@
     <script>
         DOCUMENTATION_OPTIONS.theme_version = '0.15.2';
         DOCUMENTATION_OPTIONS.theme_switcher_json_url = 'https://saezlab.github.io/corneto/dev/_static/switcher.json';
-        DOCUMENTATION_OPTIONS.theme_switcher_version_match = 'dev';
+        DOCUMENTATION_OPTIONS.theme_switcher_version_match = '1.0.0-alpha.0';
         DOCUMENTATION_OPTIONS.show_version_warning_banner = false;
         </script>
     <link rel="index" title="Index" href="../genindex.html" />
diff --git a/main/api/index.html b/main/api/index.html
index 8d941b40..4d78883c 100644
--- a/main/api/index.html
+++ b/main/api/index.html
@@ -63,7 +63,7 @@
     <script>
         DOCUMENTATION_OPTIONS.theme_version = '0.15.2';
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diff --git a/main/api/modules.html b/main/api/modules.html
index e194b1a4..5199d613 100644
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diff --git a/main/genindex.html b/main/genindex.html
index 4a786eff..523425fe 100644
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diff --git a/main/guide/index.html b/main/guide/index.html
index 69966dbd..49c59f3e 100644
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diff --git a/main/guide/interactomics/index.html b/main/guide/interactomics/index.html
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diff --git a/main/guide/interoperability/cobrapy.html b/main/guide/interoperability/cobrapy.html
index 533b5f07..2f2bed9c 100644
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diff --git a/main/guide/interoperability/cvxpy.html b/main/guide/interoperability/cvxpy.html
index 01978933..422cfd73 100644
--- a/main/guide/interoperability/cvxpy.html
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@@ -63,7 +63,7 @@
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@@ -503,25 +503,25 @@ <h1>CVXPY: Convex optimization, for everyone<a class="headerlink" href="#cvxpy-c
                                      CVXPY                                     
                                      v1.4.3                                    
 ===============================================================================
-(CVXPY) Apr 25 10:40:00 AM: Your problem has 5 variables, 2 constraints, and 0 parameters.
-(CVXPY) Apr 25 10:40:00 AM: It is compliant with the following grammars: DCP, DQCP
-(CVXPY) Apr 25 10:40:00 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)
-(CVXPY) Apr 25 10:40:00 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.
-(CVXPY) Apr 25 10:40:00 AM: Your problem is compiled with the CPP canonicalization backend.
+(CVXPY) Apr 25 10:46:24 AM: Your problem has 5 variables, 2 constraints, and 0 parameters.
+(CVXPY) Apr 25 10:46:24 AM: It is compliant with the following grammars: DCP, DQCP
+(CVXPY) Apr 25 10:46:24 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)
+(CVXPY) Apr 25 10:46:24 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.
+(CVXPY) Apr 25 10:46:24 AM: Your problem is compiled with the CPP canonicalization backend.
 -------------------------------------------------------------------------------
                                   Compilation                                  
 -------------------------------------------------------------------------------
-(CVXPY) Apr 25 10:40:00 AM: Compiling problem (target solver=OSQP).
-(CVXPY) Apr 25 10:40:00 AM: Reduction chain: CvxAttr2Constr -&gt; Qp2SymbolicQp -&gt; QpMatrixStuffing -&gt; OSQP
-(CVXPY) Apr 25 10:40:00 AM: Applying reduction CvxAttr2Constr
-(CVXPY) Apr 25 10:40:00 AM: Applying reduction Qp2SymbolicQp
-(CVXPY) Apr 25 10:40:00 AM: Applying reduction QpMatrixStuffing
-(CVXPY) Apr 25 10:40:00 AM: Applying reduction OSQP
-(CVXPY) Apr 25 10:40:00 AM: Finished problem compilation (took 9.753e-03 seconds).
+(CVXPY) Apr 25 10:46:24 AM: Compiling problem (target solver=OSQP).
+(CVXPY) Apr 25 10:46:24 AM: Reduction chain: CvxAttr2Constr -&gt; Qp2SymbolicQp -&gt; QpMatrixStuffing -&gt; OSQP
+(CVXPY) Apr 25 10:46:24 AM: Applying reduction CvxAttr2Constr
+(CVXPY) Apr 25 10:46:24 AM: Applying reduction Qp2SymbolicQp
+(CVXPY) Apr 25 10:46:24 AM: Applying reduction QpMatrixStuffing
+(CVXPY) Apr 25 10:46:24 AM: Applying reduction OSQP
+(CVXPY) Apr 25 10:46:24 AM: Finished problem compilation (took 9.047e-03 seconds).
 -------------------------------------------------------------------------------
                                 Numerical solver                               
 -------------------------------------------------------------------------------
-(CVXPY) Apr 25 10:40:00 AM: Invoking solver OSQP  to obtain a solution.
+(CVXPY) Apr 25 10:46:24 AM: Invoking solver OSQP  to obtain a solution.
 -----------------------------------------------------------------
            OSQP v0.6.3  -  Operator Splitting QP Solver
               (c) Bartolomeo Stellato,  Goran Banjac
@@ -539,24 +539,24 @@ <h1>CVXPY: Convex optimization, for everyone<a class="headerlink" href="#cvxpy-c
           warm start: on, polish: on, time_limit: off
 
 iter   objective    pri res    dua res    rho        time
-   1  -5.2220e+00   3.68e+00   1.70e+02   1.00e-01   4.35e-05s
- 150   6.9994e-01   1.96e-05   7.82e-06   4.77e+00   9.17e-05s
-plsh   7.0000e-01   1.95e-30   0.00e+00   --------   1.20e-04s
+   1  -5.2220e+00   3.68e+00   1.70e+02   1.00e-01   4.43e-05s
+ 150   6.9994e-01   1.96e-05   7.82e-06   4.77e+00   9.01e-05s
+plsh   7.0000e-01   1.95e-30   0.00e+00   --------   1.23e-04s
 
 status:               solved
 solution polish:      successful
 number of iterations: 150
 optimal objective:    0.7000
-run time:             1.20e-04s
+run time:             1.23e-04s
 optimal rho estimate: 9.81e+00
 
 -------------------------------------------------------------------------------
                                     Summary                                    
 -------------------------------------------------------------------------------
-(CVXPY) Apr 25 10:40:00 AM: Problem status: optimal
-(CVXPY) Apr 25 10:40:00 AM: Optimal value: -3.000e-01
-(CVXPY) Apr 25 10:40:00 AM: Compilation took 9.753e-03 seconds
-(CVXPY) Apr 25 10:40:00 AM: Solver (including time spent in interface) took 2.524e-03 seconds
+(CVXPY) Apr 25 10:46:24 AM: Problem status: optimal
+(CVXPY) Apr 25 10:46:24 AM: Optimal value: -3.000e-01
+(CVXPY) Apr 25 10:46:24 AM: Compilation took 9.047e-03 seconds
+(CVXPY) Apr 25 10:46:24 AM: Solver (including time spent in interface) took 1.582e-03 seconds
 </pre></div>
 </div>
 </div>
diff --git a/main/guide/interoperability/decoupler.html b/main/guide/interoperability/decoupler.html
index 81b8cc9a..772f8115 100644
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diff --git a/main/guide/interoperability/index.html b/main/guide/interoperability/index.html
index 7f32fca3..cd035a9a 100644
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diff --git a/main/guide/interoperability/liana.html b/main/guide/interoperability/liana.html
index dbed236b..6887d77e 100644
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diff --git a/main/guide/interoperability/networkx.html b/main/guide/interoperability/networkx.html
index e189bd25..975ebdd7 100644
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diff --git a/main/guide/interoperability/omnipath.html b/main/guide/interoperability/omnipath.html
index bf0885b0..8b18f853 100644
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@@ -63,7 +63,7 @@
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diff --git a/main/guide/interoperability/picos.html b/main/guide/interoperability/picos.html
index cbe272d1..45c62f1a 100644
--- a/main/guide/interoperability/picos.html
+++ b/main/guide/interoperability/picos.html
@@ -63,7 +63,7 @@
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@@ -528,7 +528,7 @@ <h1>PICOS: A Python interface to conic optimization solvers<a class="headerlink"
 Solver claims optimal solution for feasible problem.
 Applying the solution.
 Applied solution is primal feasible.
-Search 1.4e-02s, solve 1.9e-02s, overhead 31%.
+Search 1.4e-02s, solve 1.9e-02s, overhead 34%.
 =============[ PICOS ]=============
 </pre></div>
 </div>
diff --git a/main/guide/intro/acyclic-flows.html b/main/guide/intro/acyclic-flows.html
index 7def2943..4d9c856a 100644
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diff --git a/main/guide/intro/constrained-optimization.html b/main/guide/intro/constrained-optimization.html
index 0e3ba959..1418a9fd 100644
--- a/main/guide/intro/constrained-optimization.html
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@@ -63,7 +63,7 @@
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@@ -505,7 +505,7 @@ <h2>The Knapsack Problem<a class="headerlink" href="#the-knapsack-problem" title
 </div>
 </div>
 <div class="cell_output docutils container">
-<div class="output text_plain highlight-myst-ansi notranslate"><div class="highlight"><pre><span></span>&lt;corneto.backend._cvxpy_backend.CvxpyBackend at 0x7fcc1ca007d0&gt;
+<div class="output text_plain highlight-myst-ansi notranslate"><div class="highlight"><pre><span></span>&lt;corneto.backend._cvxpy_backend.CvxpyBackend at 0x7f086c7f8e50&gt;
 </pre></div>
 </div>
 </div>
@@ -542,7 +542,7 @@ <h2>The Knapsack Problem<a class="headerlink" href="#the-knapsack-problem" title
 </div>
 </div>
 <div class="cell_output docutils container">
-<div class="output text_plain highlight-myst-ansi notranslate"><div class="highlight"><pre><span></span>&lt;corneto.backend._base.ProblemDef at 0x7fcbeded6210&gt;
+<div class="output text_plain highlight-myst-ansi notranslate"><div class="highlight"><pre><span></span>&lt;corneto.backend._base.ProblemDef at 0x7f087c7beed0&gt;
 </pre></div>
 </div>
 </div>
@@ -631,29 +631,31 @@ <h2>A more complex knapsack<a class="headerlink" href="#a-more-complex-knapsack"
                                      CVXPY                                     
                                      v1.4.3                                    
 ===============================================================================
-(CVXPY) Apr 25 10:40:09 AM: Your problem has 50 variables, 1 constraints, and 0 parameters.
-(CVXPY) Apr 25 10:40:09 AM: It is compliant with the following grammars: DCP, DQCP
-(CVXPY) Apr 25 10:40:09 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)
-(CVXPY) Apr 25 10:40:09 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.
-(CVXPY) Apr 25 10:40:09 AM: Your problem is compiled with the CPP canonicalization backend.
+(CVXPY) Apr 25 10:46:32 AM: Your problem has 50 variables, 1 constraints, and 0 parameters.
+(CVXPY) Apr 25 10:46:32 AM: It is compliant with the following grammars: DCP, DQCP
+(CVXPY) Apr 25 10:46:32 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)
+(CVXPY) Apr 25 10:46:32 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.
+(CVXPY) Apr 25 10:46:32 AM: Your problem is compiled with the CPP canonicalization backend.
 -------------------------------------------------------------------------------
                                   Compilation                                  
 -------------------------------------------------------------------------------
-(CVXPY) Apr 25 10:40:09 AM: Compiling problem (target solver=SCIP).
-(CVXPY) Apr 25 10:40:09 AM: Reduction chain: FlipObjective -&gt; Dcp2Cone -&gt; CvxAttr2Constr -&gt; ConeMatrixStuffing -&gt; SCIP
-(CVXPY) Apr 25 10:40:09 AM: Applying reduction FlipObjective
-(CVXPY) Apr 25 10:40:09 AM: Applying reduction Dcp2Cone
-(CVXPY) Apr 25 10:40:09 AM: Applying reduction CvxAttr2Constr
-(CVXPY) Apr 25 10:40:09 AM: Applying reduction ConeMatrixStuffing
-(CVXPY) Apr 25 10:40:09 AM: Applying reduction SCIP
-(CVXPY) Apr 25 10:40:09 AM: Finished problem compilation (took 8.441e-03 seconds).
+(CVXPY) Apr 25 10:46:32 AM: Compiling problem (target solver=SCIP).
+(CVXPY) Apr 25 10:46:32 AM: Reduction chain: FlipObjective -&gt; Dcp2Cone -&gt; CvxAttr2Constr -&gt; ConeMatrixStuffing -&gt; SCIP
+(CVXPY) Apr 25 10:46:32 AM: Applying reduction FlipObjective
+(CVXPY) Apr 25 10:46:32 AM: Applying reduction Dcp2Cone
+(CVXPY) Apr 25 10:46:32 AM: Applying reduction CvxAttr2Constr
+(CVXPY) Apr 25 10:46:32 AM: Applying reduction ConeMatrixStuffing
+(CVXPY) Apr 25 10:46:32 AM: Applying reduction SCIP
+(CVXPY) Apr 25 10:46:32 AM: Finished problem compilation (took 8.368e-03 seconds).
 -------------------------------------------------------------------------------
                                 Numerical solver                               
 -------------------------------------------------------------------------------
-(CVXPY) Apr 25 10:40:09 AM: Invoking solver SCIP  to obtain a solution.
+(CVXPY) Apr 25 10:46:32 AM: Invoking solver SCIP  to obtain a solution.
 -------------------------------------------------------------------------------
                                     Summary                                    
--------------------------------------------------------------------------------feasible solution found by trivial heuristic after 0.0 seconds, objective value -6.000000e+02
+-------------------------------------------------------------------------------
+(CVXPY) Apr 25 10:46:32 AM: Problem status: optimal
+feasible solution found by trivial heuristic after 0.0 seconds, objective value -6.000000e+02
 presolving:
 (round 1, fast)       4 del vars, 0 del conss, 0 add conss, 0 chg bounds, 0 chg sides, 0 chg coeffs, 0 upgd conss, 0 impls, 0 clqs
 (round 2, exhaustive) 4 del vars, 0 del conss, 0 add conss, 0 chg bounds, 0 chg sides, 0 chg coeffs, 1 upgd conss, 0 impls, 0 clqs
@@ -670,11 +672,9 @@ <h2>A more complex knapsack<a class="headerlink" href="#a-more-complex-knapsack"
 Primal Bound       : -7.53400000000000e+03 (3 solutions)
 Dual Bound         : -7.53400000000000e+03
 Gap                : 0.00 %
-
-(CVXPY) Apr 25 10:40:09 AM: Problem status: optimal
-(CVXPY) Apr 25 10:40:09 AM: Optimal value: 7.534e+03
-(CVXPY) Apr 25 10:40:09 AM: Compilation took 8.441e-03 seconds
-(CVXPY) Apr 25 10:40:09 AM: Solver (including time spent in interface) took 3.624e-03 seconds
+(CVXPY) Apr 25 10:46:32 AM: Optimal value: 7.534e+03
+(CVXPY) Apr 25 10:46:32 AM: Compilation took 8.368e-03 seconds
+(CVXPY) Apr 25 10:46:32 AM: Solver (including time spent in interface) took 3.592e-03 seconds
 </pre></div>
 </div>
 <div class="output text_plain highlight-myst-ansi notranslate"><div class="highlight"><pre><span></span>Problem(Maximize(Expression(AFFINE, NONNEGATIVE, ())), [Inequality(Expression(AFFINE, NONNEGATIVE, ()))])
diff --git a/main/guide/intro/index.html b/main/guide/intro/index.html
index 195fdac1..87aa7ea0 100644
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diff --git a/main/guide/intro/multi-commodity-network-flows.html b/main/guide/intro/multi-commodity-network-flows.html
index 68136de2..b5b41e34 100644
--- a/main/guide/intro/multi-commodity-network-flows.html
+++ b/main/guide/intro/multi-commodity-network-flows.html
@@ -63,7 +63,7 @@
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@@ -572,29 +572,29 @@ <h1>Multi-commodity Network Flows<a class="headerlink" href="#multi-commodity-ne
                                      CVXPY                                     
                                      v1.4.3                                    
 ===============================================================================
-(CVXPY) Apr 25 10:40:10 AM: Your problem has 20 variables, 5 constraints, and 0 parameters.
-(CVXPY) Apr 25 10:40:10 AM: It is compliant with the following grammars: DCP, DQCP
-(CVXPY) Apr 25 10:40:10 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)
-(CVXPY) Apr 25 10:40:10 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.
-(CVXPY) Apr 25 10:40:10 AM: Your problem is compiled with the CPP canonicalization backend.
+(CVXPY) Apr 25 10:46:33 AM: Your problem has 20 variables, 5 constraints, and 0 parameters.
+(CVXPY) Apr 25 10:46:33 AM: It is compliant with the following grammars: DCP, DQCP
+(CVXPY) Apr 25 10:46:33 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)
+(CVXPY) Apr 25 10:46:33 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.
+(CVXPY) Apr 25 10:46:33 AM: Your problem is compiled with the CPP canonicalization backend.
 -------------------------------------------------------------------------------
                                   Compilation                                  
 -------------------------------------------------------------------------------
-(CVXPY) Apr 25 10:40:10 AM: Compiling problem (target solver=SCIP).
-(CVXPY) Apr 25 10:40:10 AM: Reduction chain: Dcp2Cone -&gt; CvxAttr2Constr -&gt; ConeMatrixStuffing -&gt; SCIP
-(CVXPY) Apr 25 10:40:10 AM: Applying reduction Dcp2Cone
-(CVXPY) Apr 25 10:40:10 AM: Applying reduction CvxAttr2Constr
-(CVXPY) Apr 25 10:40:10 AM: Applying reduction ConeMatrixStuffing
-(CVXPY) Apr 25 10:40:10 AM: Applying reduction SCIP
-(CVXPY) Apr 25 10:40:10 AM: Finished problem compilation (took 1.412e-02 seconds).
+(CVXPY) Apr 25 10:46:33 AM: Compiling problem (target solver=SCIP).
+(CVXPY) Apr 25 10:46:33 AM: Reduction chain: Dcp2Cone -&gt; CvxAttr2Constr -&gt; ConeMatrixStuffing -&gt; SCIP
+(CVXPY) Apr 25 10:46:33 AM: Applying reduction Dcp2Cone
+(CVXPY) Apr 25 10:46:33 AM: Applying reduction CvxAttr2Constr
+(CVXPY) Apr 25 10:46:33 AM: Applying reduction ConeMatrixStuffing
+(CVXPY) Apr 25 10:46:33 AM: Applying reduction SCIP
+(CVXPY) Apr 25 10:46:33 AM: Finished problem compilation (took 1.440e-02 seconds).
 -------------------------------------------------------------------------------
                                 Numerical solver                               
 -------------------------------------------------------------------------------
-(CVXPY) Apr 25 10:40:10 AM: Invoking solver SCIP  to obtain a solution.
+(CVXPY) Apr 25 10:46:33 AM: Invoking solver SCIP  to obtain a solution.
 -------------------------------------------------------------------------------
                                     Summary                                    
 -------------------------------------------------------------------------------
-(CVXPY) Apr 25 10:40:10 AM: Problem status: optimal
+(CVXPY) Apr 25 10:46:33 AM: Problem status: optimal
 presolving:
    (0.0s) symmetry computation started: requiring (bin +, int +, cont +), (fixed: bin -, int -, cont -)
    (0.0s) no symmetry present (symcode time: 0.00)
@@ -615,9 +615,9 @@ <h1>Multi-commodity Network Flows<a class="headerlink" href="#multi-commodity-ne
 Primal Bound       : -1.90000000000000e+02 (1 solutions)
 Dual Bound         : -1.90000000000000e+02
 Gap                : 0.00 %
-(CVXPY) Apr 25 10:40:10 AM: Optimal value: -1.900e+02
-(CVXPY) Apr 25 10:40:10 AM: Compilation took 1.412e-02 seconds
-(CVXPY) Apr 25 10:40:10 AM: Solver (including time spent in interface) took 6.421e-03 seconds
+(CVXPY) Apr 25 10:46:33 AM: Optimal value: -1.900e+02
+(CVXPY) Apr 25 10:46:33 AM: Compilation took 1.440e-02 seconds
+(CVXPY) Apr 25 10:46:33 AM: Solver (including time spent in interface) took 6.373e-03 seconds
 </pre></div>
 </div>
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diff --git a/main/guide/intro/prior-knowledge.html b/main/guide/intro/prior-knowledge.html
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@@ -709,7 +709,7 @@ <h2>Hypergraphs<a class="headerlink" href="#hypergraphs" title="Permalink to thi
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@@ -513,7 +513,7 @@ <h2>Using COBRApy<a class="headerlink" href="#using-cobrapy" title="Permalink to
                 <td><strong>Name</strong></td><td>Biomass Objective Function with GAM</td>
             </tr><tr>
                 <td><strong>Memory address</strong></td>
-                <td>0x7f4ff9f4e350</td>
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diff --git a/main/guide/metabolism/index.html b/main/guide/metabolism/index.html
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diff --git a/main/guide/metabolism/sparse-fba.html b/main/guide/metabolism/sparse-fba.html
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@@ -546,7 +546,7 @@ <h2>Manual implementation of sparse FBA<a class="headerlink" href="#manual-imple
 </div>
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 <p>Now we are going to see how to use specialized building blocks from CORNETO to automatically add indicators for the presence of reactions in a model. Indicators are binary variables associated to a continuous variable: when the indicator is 0, the continuous variable is 0; and when the indicator is 1, the continuous variable is unconstrained.</p>
 <p>By creating indicators for flow, we can try for example to minimize the number of reactions with flux in the model, by minimizing the total number of ones in the indicator vector.</p>
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@@ -599,33 +599,33 @@ <h2>Exact Steiner Trees with CORNETO<a class="headerlink" href="#exact-steiner-t
                                      CVXPY                                     
                                      v1.4.3                                    
 ===============================================================================
-(CVXPY) Apr 25 10:40:58 AM: Your problem has 310 variables, 7 constraints, and 0 parameters.
-(CVXPY) Apr 25 10:40:58 AM: It is compliant with the following grammars: DCP, DQCP
-(CVXPY) Apr 25 10:40:58 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)
-(CVXPY) Apr 25 10:40:58 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.
-(CVXPY) Apr 25 10:40:58 AM: Your problem is compiled with the CPP canonicalization backend.
+(CVXPY) Apr 25 10:47:26 AM: Your problem has 310 variables, 7 constraints, and 0 parameters.
+(CVXPY) Apr 25 10:47:26 AM: It is compliant with the following grammars: DCP, DQCP
+(CVXPY) Apr 25 10:47:26 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)
+(CVXPY) Apr 25 10:47:26 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.
+(CVXPY) Apr 25 10:47:26 AM: Your problem is compiled with the CPP canonicalization backend.
 -------------------------------------------------------------------------------
                                   Compilation                                  
 -------------------------------------------------------------------------------
-(CVXPY) Apr 25 10:40:58 AM: Compiling problem (target solver=SCIPY).
-(CVXPY) Apr 25 10:40:58 AM: Reduction chain: Dcp2Cone -&gt; CvxAttr2Constr -&gt; ConeMatrixStuffing -&gt; SCIPY
-(CVXPY) Apr 25 10:40:58 AM: Applying reduction Dcp2Cone
-(CVXPY) Apr 25 10:40:58 AM: Applying reduction CvxAttr2Constr
-(CVXPY) Apr 25 10:40:58 AM: Applying reduction ConeMatrixStuffing
-(CVXPY) Apr 25 10:40:58 AM: Applying reduction SCIPY
-(CVXPY) Apr 25 10:40:58 AM: Finished problem compilation (took 1.355e-02 seconds).
+(CVXPY) Apr 25 10:47:26 AM: Compiling problem (target solver=SCIPY).
+(CVXPY) Apr 25 10:47:26 AM: Reduction chain: Dcp2Cone -&gt; CvxAttr2Constr -&gt; ConeMatrixStuffing -&gt; SCIPY
+(CVXPY) Apr 25 10:47:26 AM: Applying reduction Dcp2Cone
+(CVXPY) Apr 25 10:47:26 AM: Applying reduction CvxAttr2Constr
+(CVXPY) Apr 25 10:47:26 AM: Applying reduction ConeMatrixStuffing
+(CVXPY) Apr 25 10:47:26 AM: Applying reduction SCIPY
+(CVXPY) Apr 25 10:47:26 AM: Finished problem compilation (took 1.438e-02 seconds).
 -------------------------------------------------------------------------------
                                 Numerical solver                               
 -------------------------------------------------------------------------------
-(CVXPY) Apr 25 10:40:58 AM: Invoking solver SCIPY  to obtain a solution.
+(CVXPY) Apr 25 10:47:26 AM: Invoking solver SCIPY  to obtain a solution.
 Solver terminated with message: Optimization terminated successfully. (HiGHS Status 7: Optimal)
 -------------------------------------------------------------------------------
                                     Summary                                    
 -------------------------------------------------------------------------------
-(CVXPY) Apr 25 10:41:32 AM: Problem status: optimal
-(CVXPY) Apr 25 10:41:32 AM: Optimal value: 4.100e+01
-(CVXPY) Apr 25 10:41:32 AM: Compilation took 1.355e-02 seconds
-(CVXPY) Apr 25 10:41:32 AM: Solver (including time spent in interface) took 3.391e+01 seconds
+(CVXPY) Apr 25 10:48:00 AM: Problem status: optimal
+(CVXPY) Apr 25 10:48:00 AM: Optimal value: 4.100e+01
+(CVXPY) Apr 25 10:48:00 AM: Compilation took 1.438e-02 seconds
+(CVXPY) Apr 25 10:48:00 AM: Solver (including time spent in interface) took 3.394e+01 seconds
 </pre></div>
 </div>
 <img alt="../../_images/7ac2b48505a5381dce8da60f48407c921ef447f293d58fdfa4eacc5f29a7aca2.svg" src="../../_images/7ac2b48505a5381dce8da60f48407c921ef447f293d58fdfa4eacc5f29a7aca2.svg" /></div>
@@ -658,33 +658,33 @@ <h2>Exact Steiner Trees with CORNETO<a class="headerlink" href="#exact-steiner-t
                                      CVXPY                                     
                                      v1.4.3                                    
 ===============================================================================
-(CVXPY) Apr 25 10:41:32 AM: Your problem has 670 variables, 17 constraints, and 0 parameters.
-(CVXPY) Apr 25 10:41:32 AM: It is compliant with the following grammars: DCP, DQCP
-(CVXPY) Apr 25 10:41:32 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)
-(CVXPY) Apr 25 10:41:32 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.
-(CVXPY) Apr 25 10:41:32 AM: Your problem is compiled with the CPP canonicalization backend.
+(CVXPY) Apr 25 10:48:00 AM: Your problem has 670 variables, 17 constraints, and 0 parameters.
+(CVXPY) Apr 25 10:48:00 AM: It is compliant with the following grammars: DCP, DQCP
+(CVXPY) Apr 25 10:48:00 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)
+(CVXPY) Apr 25 10:48:00 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.
+(CVXPY) Apr 25 10:48:00 AM: Your problem is compiled with the CPP canonicalization backend.
 -------------------------------------------------------------------------------
                                   Compilation                                  
 -------------------------------------------------------------------------------
-(CVXPY) Apr 25 10:41:32 AM: Compiling problem (target solver=SCIPY).
-(CVXPY) Apr 25 10:41:32 AM: Reduction chain: Dcp2Cone -&gt; CvxAttr2Constr -&gt; ConeMatrixStuffing -&gt; SCIPY
-(CVXPY) Apr 25 10:41:32 AM: Applying reduction Dcp2Cone
-(CVXPY) Apr 25 10:41:32 AM: Applying reduction CvxAttr2Constr
-(CVXPY) Apr 25 10:41:32 AM: Applying reduction ConeMatrixStuffing
-(CVXPY) Apr 25 10:41:32 AM: Applying reduction SCIPY
-(CVXPY) Apr 25 10:41:32 AM: Finished problem compilation (took 2.558e-02 seconds).
+(CVXPY) Apr 25 10:48:00 AM: Compiling problem (target solver=SCIPY).
+(CVXPY) Apr 25 10:48:00 AM: Reduction chain: Dcp2Cone -&gt; CvxAttr2Constr -&gt; ConeMatrixStuffing -&gt; SCIPY
+(CVXPY) Apr 25 10:48:00 AM: Applying reduction Dcp2Cone
+(CVXPY) Apr 25 10:48:00 AM: Applying reduction CvxAttr2Constr
+(CVXPY) Apr 25 10:48:00 AM: Applying reduction ConeMatrixStuffing
+(CVXPY) Apr 25 10:48:00 AM: Applying reduction SCIPY
+(CVXPY) Apr 25 10:48:00 AM: Finished problem compilation (took 2.385e-02 seconds).
 -------------------------------------------------------------------------------
                                 Numerical solver                               
 -------------------------------------------------------------------------------
-(CVXPY) Apr 25 10:41:32 AM: Invoking solver SCIPY  to obtain a solution.
+(CVXPY) Apr 25 10:48:00 AM: Invoking solver SCIPY  to obtain a solution.
 Solver terminated with message: Optimization terminated successfully. (HiGHS Status 7: Optimal)
 -------------------------------------------------------------------------------
                                     Summary                                    
 -------------------------------------------------------------------------------
-(CVXPY) Apr 25 10:41:49 AM: Problem status: optimal
-(CVXPY) Apr 25 10:41:49 AM: Optimal value: 4.100e+01
-(CVXPY) Apr 25 10:41:49 AM: Compilation took 2.558e-02 seconds
-(CVXPY) Apr 25 10:41:49 AM: Solver (including time spent in interface) took 1.722e+01 seconds
+(CVXPY) Apr 25 10:48:17 AM: Problem status: optimal
+(CVXPY) Apr 25 10:48:17 AM: Optimal value: 4.100e+01
+(CVXPY) Apr 25 10:48:17 AM: Compilation took 2.385e-02 seconds
+(CVXPY) Apr 25 10:48:17 AM: Solver (including time spent in interface) took 1.726e+01 seconds
 Optimal value: 41.0
 </pre></div>
 </div>
diff --git a/main/guide/signaling/carnival.html b/main/guide/signaling/carnival.html
index 3a8fb001..577dea1b 100644
--- a/main/guide/signaling/carnival.html
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@@ -63,7 +63,7 @@
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@@ -532,43 +532,41 @@ <h2>A toy example<a class="headerlink" href="#a-toy-example" title="Permalink to
 </div>
 </div>
 <div class="cell_output docutils container">
-<div class="output stream highlight-myst-ansi notranslate"><div class="highlight"><pre><span></span>(CORNETO) Apr 25 10:41:51 AM - INFO    : 2/2 inputs mapped to the graph
-(CORNETO) Apr 25 10:41:51 AM - INFO    : 2/2 outputs mapped to the graph
-(CORNETO) Apr 25 10:41:51 AM - INFO    : Pruning the graph with size: V x E = (6, 6)...
-(CORNETO) Apr 25 10:41:51 AM - INFO    : Finished. Final size: V x E = (6, 6).
-(CORNETO) Apr 25 10:41:51 AM - INFO    : 2/2 inputs after pruning.
-(CORNETO) Apr 25 10:41:51 AM - INFO    : 2/2 outputs after pruning.
-(CORNETO) Apr 25 10:41:51 AM - INFO    : Converting into a flow graph...
-(CORNETO) Apr 25 10:41:51 AM - INFO    : Creating a network flow problem...
-(CORNETO) Apr 25 10:41:51 AM - INFO    : Preprocess completed.
+<div class="output stream highlight-myst-ansi notranslate"><div class="highlight"><pre><span></span>(CORNETO) Apr 25 10:48:19 AM - INFO    : 2/2 inputs mapped to the graph
+(CORNETO) Apr 25 10:48:19 AM - INFO    : 2/2 outputs mapped to the graph
+(CORNETO) Apr 25 10:48:19 AM - INFO    : Pruning the graph with size: V x E = (6, 6)...
+(CORNETO) Apr 25 10:48:19 AM - INFO    : Finished. Final size: V x E = (6, 6).
+(CORNETO) Apr 25 10:48:19 AM - INFO    : 2/2 inputs after pruning.
+(CORNETO) Apr 25 10:48:19 AM - INFO    : 2/2 outputs after pruning.
+(CORNETO) Apr 25 10:48:19 AM - INFO    : Converting into a flow graph...
+(CORNETO) Apr 25 10:48:19 AM - INFO    : Creating a network flow problem...
+(CORNETO) Apr 25 10:48:19 AM - INFO    : Preprocess completed.
 ===============================================================================
                                      CVXPY                                     
                                      v1.4.3                                    
 ===============================================================================
-(CVXPY) Apr 25 10:41:51 AM: Your problem has 86 variables, 20 constraints, and 0 parameters.
-(CVXPY) Apr 25 10:41:51 AM: It is compliant with the following grammars: DCP, DQCP
-(CVXPY) Apr 25 10:41:51 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)
-(CVXPY) Apr 25 10:41:51 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.
-(CVXPY) Apr 25 10:41:51 AM: Your problem is compiled with the CPP canonicalization backend.
+(CVXPY) Apr 25 10:48:19 AM: Your problem has 86 variables, 20 constraints, and 0 parameters.
+(CVXPY) Apr 25 10:48:19 AM: It is compliant with the following grammars: DCP, DQCP
+(CVXPY) Apr 25 10:48:19 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)
+(CVXPY) Apr 25 10:48:19 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.
+(CVXPY) Apr 25 10:48:19 AM: Your problem is compiled with the CPP canonicalization backend.
 -------------------------------------------------------------------------------
                                   Compilation                                  
 -------------------------------------------------------------------------------
-(CVXPY) Apr 25 10:41:51 AM: Compiling problem (target solver=SCIP).
-(CVXPY) Apr 25 10:41:51 AM: Reduction chain: Dcp2Cone -&gt; CvxAttr2Constr -&gt; ConeMatrixStuffing -&gt; SCIP
-(CVXPY) Apr 25 10:41:51 AM: Applying reduction Dcp2Cone
-(CVXPY) Apr 25 10:41:51 AM: Applying reduction CvxAttr2Constr
-(CVXPY) Apr 25 10:41:51 AM: Applying reduction ConeMatrixStuffing
-(CVXPY) Apr 25 10:41:51 AM: Applying reduction SCIP
-(CVXPY) Apr 25 10:41:51 AM: Finished problem compilation (took 2.805e-02 seconds).
+(CVXPY) Apr 25 10:48:19 AM: Compiling problem (target solver=SCIP).
+(CVXPY) Apr 25 10:48:19 AM: Reduction chain: Dcp2Cone -&gt; CvxAttr2Constr -&gt; ConeMatrixStuffing -&gt; SCIP
+(CVXPY) Apr 25 10:48:19 AM: Applying reduction Dcp2Cone
+(CVXPY) Apr 25 10:48:19 AM: Applying reduction CvxAttr2Constr
+(CVXPY) Apr 25 10:48:19 AM: Applying reduction ConeMatrixStuffing
+(CVXPY) Apr 25 10:48:19 AM: Applying reduction SCIP
+(CVXPY) Apr 25 10:48:19 AM: Finished problem compilation (took 3.197e-02 seconds).
 -------------------------------------------------------------------------------
                                 Numerical solver                               
 -------------------------------------------------------------------------------
-(CVXPY) Apr 25 10:41:51 AM: Invoking solver SCIP  to obtain a solution.
+(CVXPY) Apr 25 10:48:19 AM: Invoking solver SCIP  to obtain a solution.
 -------------------------------------------------------------------------------
                                     Summary                                    
--------------------------------------------------------------------------------
-(CVXPY) Apr 25 10:41:51 AM: Problem status: optimal
-presolving:
+-------------------------------------------------------------------------------presolving:
 (round 1, fast)       36 del vars, 95 del conss, 0 add conss, 48 chg bounds, 1 chg sides, 23 chg coeffs, 0 upgd conss, 0 impls, 28 clqs
 (round 2, fast)       54 del vars, 129 del conss, 0 add conss, 52 chg bounds, 9 chg sides, 31 chg coeffs, 0 upgd conss, 0 impls, 20 clqs
 (round 3, fast)       63 del vars, 145 del conss, 0 add conss, 52 chg bounds, 11 chg sides, 33 chg coeffs, 0 upgd conss, 0 impls, 18 clqs
@@ -599,14 +597,13 @@ <h2>A toy example<a class="headerlink" href="#a-toy-example" title="Permalink to
 Presolving Time: 0.00
 
  time | node  | left  |LP iter|LP it/n|mem/heur|mdpt |vars |cons |rows |cuts |sepa|confs|strbr|  dualbound   | primalbound  |  gap   | compl. 
-p 0.0s|     1 |     0 |     1 |     - |  clique|   0 |  27 |  45 |  42 |   0 |  0 |   0 |   0 |-3.500000e+00 | 1.000000e-01 |    Inf | unknown
-p 0.0s|     1 |     0 |     1 |     - |   locks|   0 |  27 |  45 |  42 |   0 |  0 |   0 |   0 |-3.500000e+00 |-6.000000e-01 | 483.33%| unknown
-p 0.0s|     1 |     0 |     1 |     - | vbounds|   0 |  27 |  46 |  42 |   0 |  0 |   1 |   0 |-3.500000e+00 |-1.600000e+00 | 118.75%| unknown
-p 0.0s|     1 |     0 |     1 |     - | vbounds|   0 |  27 |  48 |  42 |   0 |  0 |   3 |   0 |-3.500000e+00 |-3.200000e+00 |   9.37%| unknown
-  0.0s|     1 |     0 |    16 |     - |  1789k |   0 |  27 |  29 |  42 |   0 |  0 |   9 |   0 |-3.300000e+00 |-3.200000e+00 |   3.13%| unknown
-  0.0s|     1 |     0 |    21 |     - |  1810k |   0 |  27 |  29 |  45 |   3 |  1 |   9 |   0 |-3.300000e+00 |-3.200000e+00 |   3.13%| unknown
-r 0.0s|     1 |     0 |    21 |     - |rounding|   0 |  27 |  29 |  45 |   3 |  1 |   9 |   0 |-3.300000e+00 |-3.300000e+00 |   0.00%| unknown
-  0.0s|     1 |     0 |    21 |     - |  1810k |   0 |  27 |  29 |  45 |   3 |  1 |   9 |   0 |-3.300000e+00 |-3.300000e+00 |   0.00%| unknown
+p 0.0s|     1 |     0 |     0 |     - |  clique|   0 |  27 |  45 |  42 |   0 |  0 |   0 |   0 |-3.500000e+00 | 1.000000e-01 |    Inf | unknown
+p 0.0s|     1 |     0 |     0 |     - |   locks|   0 |  27 |  45 |  42 |   0 |  0 |   0 |   0 |-3.500000e+00 |-6.000000e-01 | 483.33%| unknown
+p 0.0s|     1 |     0 |     0 |     - | vbounds|   0 |  27 |  45 |  42 |   0 |  0 |   0 |   0 |-3.500000e+00 |-1.600000e+00 | 118.75%| unknown
+p 0.0s|     1 |     0 |     0 |     - | vbounds|   0 |  27 |  46 |  42 |   0 |  0 |   1 |   0 |-3.500000e+00 |-3.200000e+00 |   9.37%| unknown
+  0.0s|     1 |     0 |    14 |     - |  1786k |   0 |  27 |  29 |  42 |   0 |  0 |   7 |   0 |-3.300000e+00 |-3.200000e+00 |   3.13%| unknown
+r 0.0s|     1 |     0 |    14 |     - |rounding|   0 |  27 |  29 |  42 |   0 |  0 |   7 |   0 |-3.300000e+00 |-3.300000e+00 |   0.00%| unknown
+  0.0s|     1 |     0 |    14 |     - |  1786k |   0 |  27 |  29 |  42 |   0 |  0 |   7 |   0 |-3.300000e+00 |-3.300000e+00 |   0.00%| unknown
 
 SCIP Status        : problem is solved [optimal solution found]
 Solving Time (sec) : 0.00
@@ -614,10 +611,12 @@ <h2>A toy example<a class="headerlink" href="#a-toy-example" title="Permalink to
 Primal Bound       : -3.30000000000000e+00 (5 solutions)
 Dual Bound         : -3.30000000000000e+00
 Gap                : 0.00 %
-(CVXPY) Apr 25 10:41:51 AM: Optimal value: 7.000e-01
-(CVXPY) Apr 25 10:41:51 AM: Compilation took 2.805e-02 seconds
-(CVXPY) Apr 25 10:41:51 AM: Solver (including time spent in interface) took 1.459e-02 seconds
-(CORNETO) Apr 25 10:41:51 AM - INFO    : Finished in 0.07 s.
+
+(CVXPY) Apr 25 10:48:19 AM: Problem status: optimal
+(CVXPY) Apr 25 10:48:19 AM: Optimal value: 7.000e-01
+(CVXPY) Apr 25 10:48:19 AM: Compilation took 3.197e-02 seconds
+(CVXPY) Apr 25 10:48:19 AM: Solver (including time spent in interface) took 1.419e-02 seconds
+(CORNETO) Apr 25 10:48:19 AM - INFO    : Finished in 0.07 s.
 </pre></div>
 </div>
 </div>
@@ -683,32 +682,32 @@ <h2>A toy example<a class="headerlink" href="#a-toy-example" title="Permalink to
   <tbody>
     <tr>
       <th>0</th>
-      <td>I2</td>
+      <td>M2</td>
       <td>1.0</td>
     </tr>
     <tr>
       <th>1</th>
-      <td>M1</td>
+      <td>I1</td>
       <td>1.0</td>
     </tr>
     <tr>
       <th>2</th>
-      <td>N1</td>
-      <td>0.0</td>
+      <td>N2</td>
+      <td>-1.0</td>
     </tr>
     <tr>
       <th>3</th>
-      <td>N2</td>
-      <td>-1.0</td>
+      <td>N1</td>
+      <td>0.0</td>
     </tr>
     <tr>
       <th>4</th>
-      <td>I1</td>
+      <td>M1</td>
       <td>1.0</td>
     </tr>
     <tr>
       <th>5</th>
-      <td>M2</td>
+      <td>I2</td>
       <td>1.0</td>
     </tr>
     <tr>
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