See also: Awesome Mega Drive Games
- The Adventures Of Batman & Robin
- Alien 3
- Batman ‡
- Blades of Vengeance ‡
- Demolition Man †
- Desert Strike †
- Ex-Ranza ~ Ranger X ‡
- Granada X ‡
- Jungle Strike †
- The Legend of Galahad ~ Leander
- Prince of Persia
- Moonwalker ‡
- Mystic Defender ~ Kujakuō 2: Geneijō ‡
- Panorama Cotton ‡
- Robocop Versus the Terminator †
- Rolling Thunder 3 ‡
- Shadow Blasters ‡
- Ultracore ‡
- Universal Soldier ~ Turrican II
- Valis III †
- Wardner
- X-Men 2: Clone Wars
- Arcus Odyssey
- The Immortal
- Land Stalker ‡
- Light Crusader ‡
- Aero Blasters ~ Air Buster
- Atomic Robo-Kid
- Atomic Runner †
- Bonanza Bros.
- Chiki Chiki Boys ~ Mega Twins
- Dangerous Seed
- Double Dragon
- Fire Mustang
- Gauntlet 4
- Insector X
- Joe & Mac
- Mercs ~ Senjou No Ookami II
- Midnight Resistance
- NBA Jam
- The Punisher
- Puyo Puyo
- Raiden Trad
- Sagaia ~ Darius II
- Slap Fight MD
- Space Invaders 91
- Sunset Riders
- V-V ~ Grindstormer
- Vapor Trail
- Arrow Flash ‡
- Battle Mania ~ Trouble Shooter ‡
- Battle Mania Daiginjō ‡
- Bio-Hazard Battle ~ Crying: Aseimei Sensou ‡
- Elemental Master ‡
- Phelios ‡
- Sol Deace ‡
- Steel Empire ~ Empire of Steel, Koutetsu Teikoku ‡
- Super Fantasy Zone ‡
- Twinkle Tale ‡
- Undead Line ‡
- Verytex ‡
- Whip Rush ‡
- Bare Knuckles III ~ Streets of Rage III ‡
- Battletoads & Double Dragon †
- Golden Axe II ‡
- Golden Axe III ‡
- Mazin Saga/Mazin Wars ‡
- Mystical Fighter ‡
- Pirates of Dark Water
- Spider-Man: Maximum Carnage
- Splatter House 3 ‡
- Yu Yu Hakusho ~ Yū Yū Hakusho: Makyō Tōitsusen ‡
- The Addams Family
- Aladdin ‡
- Battletoads
- Cool Spot †
- Earthworm Jim 2 †
- Flink
- The Great Circus Mystery ~ The Magical Quest 2 Starring Mickey and Minnie
- High Seas Havoc
- Marvel Land
- Mr. Nutz
- Pulseman
- Robocod
- Sonic the Hedgehog 3 & Knuckles ‡
- Sparkster
- Tinhead
- Vectorman ‡
- Vectorman 2 ‡
- Wonderboy Monster World IV ‡
- World of Illusion ‡
- Wiz 'n' Liz †
- ShiKinJou ‡
- Wani Wani World ‡
- Championship Pro-Am ‡
- Combat Cars ‡
- F1 ~ Vroom
- Lotus Turbo Challenge ~ Lotus II
- Lotus II ~ Lotus III
- Outrun 2019
- Road Blasters
- Road Rash 3 ‡
- Skitchin'
- Super Monaco GP ‡
- Super Off Road
- Super Skidmarks
- Crusader of Centy ~ Soleil ‡
- King's Bounty
- Phantasy Star II ‡
- Phantasy Star III ‡
- Shining in the Darkness ‡
- Sword of Vermillon
- Warsong ~ Langrisser
- Ys III: Wanderers from Ys †
- Dune - The Battle for Arrakis ~ Dune II
- Pirates! Gold
- Star Control
- Starflight
- Tyrants ~ Mega-Lo-Mania
- Dino Dini's Soccer ~ Goal!
- Lemmings 2 Tribes
- Puggsy
- Shadow of the Beast
- Shadow of the Beast II
- Storm Lord
- Super Kick Off