diff --git a/cache.py b/cache.py
new file mode 100644
index 0000000..c4d859a
--- /dev/null
+++ b/cache.py
@@ -0,0 +1,39 @@
+import functools
+import pathlib
+
+import appdirs
+import daiquiri
+import diskcache
+
+logger = daiquiri.getLogger("cache")
+
+
+def get_cache_dir():
+    cache_dir = pathlib.Path(appdirs.user_cache_dir("tsqc", "tsqc"))
+    cache_dir.mkdir(exist_ok=True, parents=True)
+    return cache_dir
+
+
+cache = diskcache.Cache(get_cache_dir())
+
+
+def disk_cache(version):
+    def decorator(func):
+        @functools.wraps(func)
+        def wrapper(self, *args, **kwargs):
+            uuid = self.file_uuid
+            if uuid is None:
+                logger.info(f"No uuid, not caching {func.__name__}")
+                return func(self, *args, **kwargs)
+            key = f"{self.file_uuid}-{func.__name__}-{version}"
+            if key in cache:
+                logger.info(f"Fetching {key} from cache")
+                return cache[key]
+            logger.info(f"Calculating {key} and caching")
+            result = func(self, *args, **kwargs)
+            cache[key] = result
+            return result
+
+        return wrapper
+
+    return decorator
diff --git a/model.py b/model.py
index bb81dfd..b5b5a5f 100644
--- a/model.py
+++ b/model.py
@@ -7,6 +7,9 @@
 import pandas as pd
 import tskit
 
+from cache import disk_cache
+
+
 logger = daiquiri.getLogger("model")
 
 spec = [
@@ -271,7 +274,12 @@ def __init__(self, ts, name=None):
             self.ts.mutations_node, minlength=self.ts.num_nodes
         )
 
+    @property
+    def file_uuid(self):
+        return self.ts.file_uuid
+
     @cached_property
+    @disk_cache("v1")
     def summary_df(self):
         nodes_with_zero_muts = np.sum(self.nodes_num_mutations == 0)
         sites_with_zero_muts = np.sum(self.sites_num_mutations == 0)
@@ -312,6 +320,7 @@ def child_bounds(num_nodes, edges_left, edges_right, edges_child):
         return child_left, child_right
 
     @cached_property
+    @disk_cache("v1")
     def mutations_df(self):
         # FIXME use tskit's impute mutations time
         ts = self.ts
@@ -386,6 +395,7 @@ def mutations_df(self):
         )
 
     @cached_property
+    @disk_cache("v1")
     def edges_df(self):
         ts = self.ts
         left = ts.edges_left
@@ -426,6 +436,7 @@ def edges_df(self):
         )
 
     @cached_property
+    @disk_cache("v1")
     def nodes_df(self):
         ts = self.ts
         child_left, child_right = self.child_bounds(
@@ -452,6 +463,7 @@ def nodes_df(self):
         )
 
     @cached_property
+    @disk_cache("v1")
     def trees_df(self):
         ts = self.ts
         num_trees = ts.num_trees
diff --git a/requirements.txt b/requirements.txt
index 3d5fb46..376a01e 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -1,6 +1,7 @@
 click
 daiquiri
 panel
+diskcache
 hvplot
 xarray
 datashader
@@ -8,3 +9,5 @@ tskit
 seaborn
 pre-commit
 pytest
+tszip
+appdirs
diff --git a/tests/test_data_model.py b/tests/test_data_model.py
index 2501bbb..a88a211 100644
--- a/tests/test_data_model.py
+++ b/tests/test_data_model.py
@@ -1,3 +1,5 @@
+import logging
+
 import numpy as np
 import numpy.testing as nt
 import tskit
@@ -212,3 +214,29 @@ def test_multi_tree_with_polytomies_example(self):
         nt.assert_array_equal(df.total_branch_length, [11.0, 12.0])
         # nt.assert_array_equal(df.mean_internal_arity, [2.25, 2.25])
         nt.assert_array_equal(df.max_internal_arity, [3.0, 3.0])
+
+
+def test_cache(caplog, tmpdir):
+    caplog.set_level(logging.INFO)
+    ts = multiple_trees_example_ts()
+    tsm = model.TSModel(ts)
+    # Use the logging out put to determine cache usage
+    t1 = tsm.trees_df
+    t2 = tsm.trees_df
+    assert t1.equals(t2)
+    assert "No uuid, not caching trees_df" in caplog.text
+
+    ts.dump(tmpdir / "cache.trees")
+    ts = tskit.load(tmpdir / "cache.trees")
+    tsm = model.TSModel(ts)
+    # Use the logging out put to determine cache usage
+    caplog.clear()
+    t1 = tsm.trees_df
+    assert "Calculating" in caplog.text
+    caplog.clear()
+
+    ts2 = tskit.load(tmpdir / "cache.trees")
+    tsm2 = model.TSModel(ts2)
+    t2 = tsm2.trees_df
+    assert "Fetching" in caplog.text
+    assert t1.equals(t2)