diff --git a/go/test/endtoend/vreplication/vdiff2_test.go b/go/test/endtoend/vreplication/vdiff2_test.go
index 2011f8613c8..99e5afa9b55 100644
--- a/go/test/endtoend/vreplication/vdiff2_test.go
+++ b/go/test/endtoend/vreplication/vdiff2_test.go
@@ -220,13 +220,13 @@ func testWorkflow(t *testing.T, vc *VitessCluster, tc *testCase, cells []*Cell)
 func testCLIErrors(t *testing.T, ksWorkflow, cells string) {
 	t.Run("Client error handling", func(t *testing.T) {
 		_, output := performVDiff2Action(t, ksWorkflow, cells, "badcmd", "", true)
-		require.Contains(t, output, "usage:")
+		require.Contains(t, output, "Usage:")
 		_, output = performVDiff2Action(t, ksWorkflow, cells, "create", "invalid_uuid", true)
-		require.Contains(t, output, "please provide a valid UUID")
+		require.Contains(t, output, "invalid UUID provided")
 		_, output = performVDiff2Action(t, ksWorkflow, cells, "resume", "invalid_uuid", true)
-		require.Contains(t, output, "can only resume a specific vdiff, please provide a valid UUID")
+		require.Contains(t, output, "invalid UUID provided")
 		_, output = performVDiff2Action(t, ksWorkflow, cells, "delete", "invalid_uuid", true)
-		require.Contains(t, output, "can only delete a specific vdiff, please provide a valid UUID")
+		require.Contains(t, output, "invalid UUID provided")
 		uuid, _ := performVDiff2Action(t, ksWorkflow, cells, "show", "last", false)
 		_, output = performVDiff2Action(t, ksWorkflow, cells, "create", uuid, true)
 		require.Contains(t, output, "already exists")
@@ -312,7 +312,7 @@ func testResume(t *testing.T, tc *testCase, cells string) {
 
 		// confirm that the VDiff was resumed, able to complete, and we compared the
 		// expected number of rows in total (original run and resume)
-		uuid, _ = performVDiff2Action(t, ksWorkflow, cells, "resume", uuid, false)
+		_, _ = performVDiff2Action(t, ksWorkflow, cells, "resume", uuid, false)
 		info := waitForVDiff2ToComplete(t, ksWorkflow, cells, uuid, ogTime)
 		require.False(t, info.HasMismatch)
 		require.Equal(t, expectedRows, info.RowsCompared)
diff --git a/go/test/endtoend/vreplication/vdiff_helper_test.go b/go/test/endtoend/vreplication/vdiff_helper_test.go
index 982ea04c957..ab4e251e49f 100644
--- a/go/test/endtoend/vreplication/vdiff_helper_test.go
+++ b/go/test/endtoend/vreplication/vdiff_helper_test.go
@@ -173,19 +173,27 @@ func doVdiff2(t *testing.T, keyspace, workflow, cells string, want *expectedVDif
 
 func performVDiff2Action(t *testing.T, ksWorkflow, cells, action, actionArg string, expectError bool, extraFlags ...string) (uuid string, output string) {
 	var err error
-	args := []string{"VDiff", "--", "--tablet_types=primary", "--source_cell=" + cells, "--format=json"}
+	targetKeyspace, workflowName, ok := strings.Cut(ksWorkflow, ".")
+	require.True(t, ok, "invalid keyspace.workflow value: %s", ksWorkflow)
+
+	args := []string{"VDiff", "--target-keyspace", targetKeyspace, "--workflow", workflowName, "--format=json", action}
+	if strings.ToLower(action) == string(vdiff2.CreateAction) {
+		args = append(args, "--tablet-types=primary", "--source-cells="+cells)
+	}
 	if len(extraFlags) > 0 {
 		args = append(args, extraFlags...)
 	}
-	args = append(args, ksWorkflow, action, actionArg)
-	output, err = vc.VtctlClient.ExecuteCommandWithOutput(args...)
+	if actionArg != "" {
+		args = append(args, actionArg)
+	}
+	output, err = vc.VtctldClient.ExecuteCommandWithOutput(args...)
 	log.Infof("vdiff2 output: %+v (err: %+v)", output, err)
 	if !expectError {
-		require.Nil(t, err)
-		uuid = gjson.Get(output, "UUID").String()
-		if action != "delete" && !(action == "show" && actionArg == "all") { // a UUID is not required
-			require.NoError(t, err)
-			require.NotEmpty(t, uuid)
+		require.NoError(t, err)
+		ouuid := gjson.Get(output, "UUID").String()
+		if action == "create" || (action == "show" && actionArg != "all") { // A UUID is returned
+			require.NotEmpty(t, ouuid)
+			uuid = ouuid
 		}
 	}
 	return uuid, output