bntseq.h

/* The MIT License

   Copyright (c) 2018-     Dana-Farber Cancer Institute
                 2009-2018 Broad Institute, Inc.
                 2008-2009 Genome Research Ltd. (GRL)

   Permission is hereby granted, free of charge, to any person obtaining
   a copy of this software and associated documentation files (the
   "Software"), to deal in the Software without restriction, including
   without limitation the rights to use, copy, modify, merge, publish,
   distribute, sublicense, and/or sell copies of the Software, and to
   permit persons to whom the Software is furnished to do so, subject to
   the following conditions:

   The above copyright notice and this permission notice shall be
   included in all copies or substantial portions of the Software.

   THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
   EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
   MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
   NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS
   BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN
   ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN
   CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
   SOFTWARE.
*/

#ifndef BWT_BNTSEQ_H
#define BWT_BNTSEQ_H

#include <assert.h>
#include <stdint.h>
#include <stdio.h>
#include <zlib.h>

#ifndef BWA_UBYTE
#define BWA_UBYTE
typedef uint8_t ubyte_t;
#endif

typedef struct {
	int64_t offset;
	int32_t len;
	int32_t n_ambs;
	uint32_t gi;
	int32_t is_alt;
	char *name, *anno;
} bntann1_t;

typedef struct {
	int64_t offset;
	int32_t len;
	char amb;
} bntamb1_t;

typedef struct {
	int64_t l_pac;
	int32_t n_seqs;
	uint32_t seed;
	bntann1_t *anns; // n_seqs elements
	int32_t n_holes;
	bntamb1_t *ambs; // n_holes elements
	FILE *fp_pac;
} bntseq_t;

extern unsigned char nst_nt4_table[256];

#ifdef __cplusplus
extern "C" {
#endif

	void bns_dump(const bntseq_t *bns, const char *prefix);
	bntseq_t *bns_restore(const char *prefix);
	bntseq_t *bns_restore_core(const char *ann_filename, const char* amb_filename, const char* pac_filename);
	void bns_destroy(bntseq_t *bns);
	int64_t bns_fasta2bntseq(gzFile fp_fa, const char *prefix, int for_only);
	int bns_pos2rid(const bntseq_t *bns, int64_t pos_f);
	int bns_cnt_ambi(const bntseq_t *bns, int64_t pos_f, int len, int *ref_id);
	uint8_t *bns_get_seq(int64_t l_pac, const uint8_t *pac, int64_t beg, int64_t end, int64_t *len);
	uint8_t *bns_fetch_seq(const bntseq_t *bns, const uint8_t *pac, int64_t *beg, int64_t mid, int64_t *end, int *rid);
	int bns_intv2rid(const bntseq_t *bns, int64_t rb, int64_t re);

#ifdef __cplusplus
}
#endif

static inline int64_t bns_depos(const bntseq_t *bns, int64_t pos, int *is_rev)
{
	return (*is_rev = (pos >= bns->l_pac))? (bns->l_pac<<1) - 1 - pos : pos;
}

#endif