diff --git a/articles/MultiAssayExperiment_Analysis.html b/articles/MultiAssayExperiment_Analysis.html index 1876b88..25ee684 100644 --- a/articles/MultiAssayExperiment_Analysis.html +++ b/articles/MultiAssayExperiment_Analysis.html @@ -109,7 +109,7 @@

Marcel NY

Levi Waldron

- CUNY School of Public Health, New York, NY

September 26, 2023

+ CUNY School of Public Health, New York, NY

November 21, 2023

Source: vignettes/MultiAssayExperiment_Analysis.Rmd diff --git a/articles/Ramos_MultiAssayExperiment.html b/articles/Ramos_MultiAssayExperiment.html index 1127413..e1d1ee1 100644 --- a/articles/Ramos_MultiAssayExperiment.html +++ b/articles/Ramos_MultiAssayExperiment.html @@ -109,7 +109,7 @@

Marcel NY

Levi Waldron

- CUNY School of Public Health, New York, NY

September 26, 2023

+ CUNY School of Public Health, New York, NY

November 21, 2023

Source: vignettes/Ramos_MultiAssayExperiment.Rmd @@ -1009,40 +1009,40 @@

Listing the studies available
 cbio <- cBioPortal()
 getStudies(cbio)
-
## # A tibble: 391 × 13
+
## # A tibble: 393 × 13
 ##    name          description publicStudy groups status importDate allSampleCount
 ##    <chr>         <chr>       <lgl>       <chr>   <int> <chr>               <int>
 ##  1 Adrenocortic… "TCGA Adre… TRUE        PUBLIC      0 2023-06-1…             92
 ##  2 Acute Myeloi… "TCGA Acut… TRUE        PUBLIC      0 2023-06-1…            200
 ##  3 Bladder Urot… "TCGA Blad… TRUE        PUBLIC      0 2023-06-1…            413
-##  4 Breast Invas… "TCGA Brea… TRUE        PUBLIC      0 2023-06-1…           1108
-##  5 Kidney Renal… "TCGA Kidn… TRUE        PUBLIC      0 2023-06-1…            538
-##  6 Cervical Squ… "TCGA Cerv… TRUE        PUBLIC      0 2023-06-1…            310
-##  7 Cholangiocar… "TCGA Chol… TRUE        PUBLIC      0 2023-06-1…             51
-##  8 Kidney Chrom… "TCGA Kidn… TRUE        PUBLIC      0 2023-06-1…            113
-##  9 Colorectal A… "TCGA Colo… TRUE        PUBLIC      0 2023-06-1…            640
-## 10 Lymphoid Neo… "TCGA Lymp… TRUE        PUBLIC      0 2023-06-1…             48
-## # ℹ 381 more rows
+##  4 Kidney Renal… "TCGA Kidn… TRUE        PUBLIC      0 2023-06-1…            538
+##  5 Cervical Squ… "TCGA Cerv… TRUE        PUBLIC      0 2023-06-1…            310
+##  6 Cholangiocar… "TCGA Chol… TRUE        PUBLIC      0 2023-06-1…             51
+##  7 Kidney Chrom… "TCGA Kidn… TRUE        PUBLIC      0 2023-06-1…            113
+##  8 Colorectal A… "TCGA Colo… TRUE        PUBLIC      0 2023-06-1…            640
+##  9 Lymphoid Neo… "TCGA Lymp… TRUE        PUBLIC      0 2023-06-1…             48
+## 10 Esophageal C… "TCGA Esop… TRUE        PUBLIC      0 2023-06-1…            186
+## # ℹ 383 more rows
 ## # ℹ 6 more variables: readPermission <lgl>, studyId <chr>, cancerTypeId <chr>,
 ## #   referenceGenome <chr>, pmid <chr>, citation <chr>

We can also see the build status of the datasets using the buildReport argument.

 getStudies(cbio, buildReport = TRUE)
-
## # A tibble: 391 × 15
+
## # A tibble: 393 × 15
 ##    name          description publicStudy groups status importDate allSampleCount
 ##    <chr>         <chr>       <lgl>       <chr>   <int> <chr>               <int>
 ##  1 Adrenocortic… "TCGA Adre… TRUE        PUBLIC      0 2023-06-1…             92
 ##  2 Acute Myeloi… "TCGA Acut… TRUE        PUBLIC      0 2023-06-1…            200
 ##  3 Bladder Urot… "TCGA Blad… TRUE        PUBLIC      0 2023-06-1…            413
-##  4 Breast Invas… "TCGA Brea… TRUE        PUBLIC      0 2023-06-1…           1108
-##  5 Kidney Renal… "TCGA Kidn… TRUE        PUBLIC      0 2023-06-1…            538
-##  6 Cervical Squ… "TCGA Cerv… TRUE        PUBLIC      0 2023-06-1…            310
-##  7 Cholangiocar… "TCGA Chol… TRUE        PUBLIC      0 2023-06-1…             51
-##  8 Kidney Chrom… "TCGA Kidn… TRUE        PUBLIC      0 2023-06-1…            113
-##  9 Colorectal A… "TCGA Colo… TRUE        PUBLIC      0 2023-06-1…            640
-## 10 Lymphoid Neo… "TCGA Lymp… TRUE        PUBLIC      0 2023-06-1…             48
-## # ℹ 381 more rows
+##  4 Kidney Renal… "TCGA Kidn… TRUE        PUBLIC      0 2023-06-1…            538
+##  5 Cervical Squ… "TCGA Cerv… TRUE        PUBLIC      0 2023-06-1…            310
+##  6 Cholangiocar… "TCGA Chol… TRUE        PUBLIC      0 2023-06-1…             51
+##  7 Kidney Chrom… "TCGA Kidn… TRUE        PUBLIC      0 2023-06-1…            113
+##  8 Colorectal A… "TCGA Colo… TRUE        PUBLIC      0 2023-06-1…            640
+##  9 Lymphoid Neo… "TCGA Lymp… TRUE        PUBLIC      0 2023-06-1…             48
+## 10 Esophageal C… "TCGA Esop… TRUE        PUBLIC      0 2023-06-1…            186
+## # ℹ 383 more rows
 ## # ℹ 8 more variables: readPermission <lgl>, studyId <chr>, cancerTypeId <chr>,
 ## #   referenceGenome <chr>, pmid <chr>, citation <chr>, api_build <lgl>,
 ## #   pack_build <lgl>
@@ -1058,18 +1058,17 @@

cBioDataPacklibrary(cBioPortalData) (uvm <- cBioDataPack("uvm_tcga"))

-
## A MultiAssayExperiment object of 9 listed
+
## A MultiAssayExperiment object of 8 listed
 ##  experiments with user-defined names and respective classes.
-##  Containing an ExperimentList class object of length 9:
+##  Containing an ExperimentList class object of length 8:
 ##  [1] cna_hg19.seg: RaggedExperiment with 7618 rows and 80 columns
-##  [2] CNA: SummarizedExperiment with 24776 rows and 80 columns
-##  [3] linear_CNA: SummarizedExperiment with 24776 rows and 80 columns
-##  [4] methylation_hm450: SummarizedExperiment with 15469 rows and 80 columns
-##  [5] mutations_extended: RaggedExperiment with 2174 rows and 80 columns
-##  [6] mutations_mskcc: RaggedExperiment with 2174 rows and 80 columns
-##  [7] RNA_Seq_v2_expression_median: SummarizedExperiment with 20531 rows and 80 columns
-##  [8] RNA_Seq_v2_mRNA_median_all_sample_Zscores: SummarizedExperiment with 20531 rows and 80 columns
-##  [9] RNA_Seq_v2_mRNA_median_Zscores: SummarizedExperiment with 20440 rows and 80 columns
+##  [2] cna: SummarizedExperiment with 24776 rows and 80 columns
+##  [3] linear_cna: SummarizedExperiment with 24776 rows and 80 columns
+##  [4] methylation_hm450: SummarizedExperiment with 15468 rows and 80 columns
+##  [5] mrna_seq_v2_rsem_zscores_ref_all_samples: SummarizedExperiment with 20531 rows and 80 columns
+##  [6] mrna_seq_v2_rsem_zscores_ref_diploid_samples: SummarizedExperiment with 20440 rows and 80 columns
+##  [7] mrna_seq_v2_rsem: SummarizedExperiment with 20531 rows and 80 columns
+##  [8] mutations: RaggedExperiment with 2174 rows and 80 columns
 ## Functionality:
 ##  experiments() - obtain the ExperimentList instance
 ##  colData() - the primary/phenotype DataFrame
diff --git a/articles/cBioPortal_Studies.html b/articles/cBioPortal_Studies.html
index a9bbc92..d98c233 100644
--- a/articles/cBioPortal_Studies.html
+++ b/articles/cBioPortal_Studies.html
@@ -318,55 +318,6 @@ 

cBioPortalData() && cBioDataPack()< -Breast Invasive Carcinoma (TCGA, Firehose Legacy) - - -TCGA Breast Invasive Carcinoma. Source data from -GDAC -Firehose. Previously known as TCGA Provisional. - - -TRUE - - -PUBLIC - - -0 - - -2023-06-19 09:47:32 - - -1108 - - -TRUE - - -brca_tcga - - -brca - - -hg19 - - -NA - - -NA - - -TRUE - - -TRUE - - - - Kidney Renal Clear Cell Carcinoma (TCGA, Firehose Legacy) @@ -2942,54 +2893,6 @@

cBioPortalData() && cBioDataPack()< -Urothelial Carcinoma (BCAN/HCRN, 2022) - - -UC-GENOME: Urothelial Cancer-GENOmic analysis to iMprove patient -outcomes and rEsearch. - - -TRUE - - -UCGENOME_BCAN_HCRN_2015 - - -0 - - -2023-06-19 14:31:55 - - -192 - - -TRUE - - -blca_bcan_hcrn_2022 - - -blca - - -hg19 - - -NA - - -NA - - -FALSE - - -TRUE - - - - Pediatric Brain Cancer (CPTAC/CHOP, Cell 2020) @@ -10089,54 +9992,6 @@

cBioPortalData() && cBioDataPack()< -Non-Small Cell Lung Cancer (MSK, Science 2015) - - -Whole-exome sequencing of tumor-normal tissue pairs from 16 non-small -cell lung cancer samples. - - -TRUE - - -PUBLIC - - -0 - - -2023-06-20 12:45:01 - - -16 - - -TRUE - - -nsclc_mskcc_2015 - - -nsclc - - -hg19 - - -25765070 - - -Rivzi et al. Science 2016 - - -TRUE - - -TRUE - - - - Prostate Cancer (MSK, Cell Metab 2020) @@ -12663,53 +12518,6 @@

cBioPortalData() && cBioDataPack()< -Mature T and NK Neoplasms (MSK, 2022) - - -Targeted sequencing of 132 Mature T and NK Neoplasms and their matched -normals via MSK-IMPACT. - - -TRUE - - - - -0 - - -2023-06-21 14:17:35 - - -132 - - -TRUE - - -mtnn_msk_2022 - - -mtnn - - -hg19 - - -NA - - -NA - - -FALSE - - -FALSE - - - - Radiation-associated Sarcomas (MSK, 2023) @@ -15427,53 +15235,6 @@

cBioPortalData() && cBioDataPack()< -Cervical Cancer (MSK, 2023) - - -Targeted Sequencing of 177 cervical tumors and their matched normal -samples via MSK-IMPACT. - - -TRUE - - - - -0 - - -2023-07-24 16:03:07 - - -177 - - -TRUE - - -cervix_msk_2023 - - -cervix - - -hg19 - - -NA - - -NA - - -NA - - -NA - - - - Prostate Adenocarcinoma (Broad/Cornell, Cell 2013) @@ -18707,24 +18468,13 @@

cBioPortalData() && cBioDataPack()< -MSK MetTropism (MSK, Cell 2021) +Metastatic Non-Small Cell Lung Cancer (MSK, Nature Medicine 2022) -MSK-MET (Memorial Sloan Kettering - Metastatic Events and Tropisms) is -an integrated pan-cancer cohort of tumor genomic and clinical outcome -data from 25,000 patients. We analyzed this dataset to identify -associations between tumor genomic alterations and patterns of -metastatic dissemination across 50 tumor types. We found that -chromosomal instability is strongly correlated with metastatic burden in -some tumor types, including prostate adenocarcinoma, lung adenocarcinoma -and HR+/HER2+ breast ductal carcinoma, but not in others, such as -colorectal MSS, pancreatic adenocarcinoma and high-grade serous ovarian -cancer. We also identified specific somatic alterations associated with -increased metastatic burden and specific routes of metastatic spread. -Our data offer a unique resource for the investigation of the biologic -basis for metastatic spread and highlight the crucial role of -chromosomal instability in cancer progression. -PubMed +Targeted sequencing of ctDNA samples drawn from patients with metastatic +NSCLC using the Resolution ctDx Lung platform. For more information +contact +or TRUE @@ -18735,28 +18485,28 @@

cBioPortalData() && cBioDataPack()< 0 -2023-08-16 20:03:15 +2023-08-16 22:58:19 -25775 +2621 TRUE -msk_met_2021 +nsclc_ctdx_msk_2022 -mixed +nsclc hg19 -35120664 +36357680 -Nguyen et al. Cell 2022 +Jee et al. Nature Medicine 2022 FALSE @@ -18767,13 +18517,11 @@

cBioPortalData() && cBioDataPack()< -Metastatic Non-Small Cell Lung Cancer (MSK, Nature Medicine 2022) +Pancreatic Neuroendocrine Tumors (MSK, 2023) -Targeted sequencing of ctDNA samples drawn from patients with metastatic -NSCLC using the Resolution ctDx Lung platform. For more information -contact -or +Targeted sequencing of 65 Pancreatic Neuroendocrine tumors/normal pairs +via MSK-IMPACT. TRUE @@ -18784,28 +18532,216 @@

cBioPortalData() && cBioDataPack()< 0 -2023-08-16 22:58:19 +2023-08-21 20:20:39 -2621 +65 TRUE -nsclc_ctdx_msk_2022 +panc_msk_2023 -nsclc +pancreas hg19 -36357680 +NA -Jee et al. Nature Medicine 2022 +NA + + +NA + + +NA + + + + +Endometrial Carcinoma Ancestry (MSK, Cancer Discovery 2023) + + +Targeted sequencing of 1882 Endometrial Cancer tumor and normal pairs +via MSK-IMPACT. + + +TRUE + + + + +0 + + +2023-09-01 08:02:50 + + +1882 + + +TRUE + + +ucec_ancestry_cds_msk_2023 + + +ucec + + +hg19 + + +NA + + +NA + + +NA + + +NA + + + + +Esophageal/Stomach Cancer (MSK, 2023) + + +Targeted sequencing of 902 Esophageal/stomach cancer patients via +MSK-IMPACT. + + +TRUE + + + + +0 + + +2023-09-05 16:02:41 + + +902 + + +TRUE + + +egc_msk_2023 + + +stomach + + +hg19 + + +NA + + +NA + + +NA + + +NA + + + + +MSK-IMPACT Heme Tumors (MSK, 2022) + + +Targeted sequencing of 2383 myeloid and lymphoid neoplasms and their +matched normals via MSK-IMPACT Heme panel. + + +TRUE + + + + +0 + + +2023-09-08 16:02:51 + + +2383 + + +TRUE + + +heme_msk_impact_2022 + + +mixed + + +hg19 + + +NA + + +NA + + +NA + + +NA + + + + +Urothelial Carcinoma (BCAN/HCRN, Nat Commun 2022) + + +UC-GENOME: Urothelial Cancer-GENOmic analysis to iMprove patient +outcomes and rEsearch. + + +TRUE + + + + +0 + + +2023-10-10 16:25:54 + + +192 + + +TRUE + + +blca_bcan_hcrn_2022 + + +blca + + +hg19 + + +36333289 + + +Damrauer et al. Nat Commun. 2022 FALSE @@ -18816,7 +18752,7 @@

cBioPortalData() && cBioDataPack()< -Sequential Rhabdomyosarcomas (MSK, Nature Precision Oncology 2023) +Sequential Rhabdomyosarcomas (MSK, NPJ Precis Oncol 2023) Targeted sequencing of 42 rhabdomyosarcoma tumors and their matched @@ -18831,7 +18767,7 @@

cBioPortalData() && cBioDataPack()< 0 -2023-08-21 20:18:46 +2023-10-10 16:56:24 42 @@ -18849,10 +18785,10 @@

cBioPortalData() && cBioDataPack()< hg19 -NA +37730754 -NA +Wardin et at. NPJ Precis Oncol. 2023 NA @@ -18863,11 +18799,12 @@

cBioPortalData() && cBioDataPack()< -Pancreatic Neuroendocrine Tumors (MSK, 2023) +Diffuse Glioma (MSK, 2023) -Targeted sequencing of 65 Pancreatic Neuroendocrine tumors/normal pairs -via MSK-IMPACT. +Targeted sequencing of 73 diffuse gliomas and their matched normal pairs +via MSK-IMPACT platforms. The data is available on +Synapse. TRUE @@ -18878,19 +18815,19 @@

cBioPortalData() && cBioDataPack()< 0 -2023-08-21 20:20:39 +2023-10-17 08:23:16 -65 +73 TRUE -panc_msk_2023 +difg_msk_2023 -pancreas +difg hg19 @@ -18910,11 +18847,164 @@

cBioPortalData() && cBioDataPack()< +MSK MetTropism (MSK, Cell 2021) + + +MSK-MET (Memorial Sloan Kettering - Metastatic Events and Tropisms) is +an integrated pan-cancer cohort of tumor genomic and clinical outcome +data from 25,000 patients. We analyzed this dataset to identify +associations between tumor genomic alterations and patterns of +metastatic dissemination across 50 tumor types. We found that +chromosomal instability is strongly correlated with metastatic burden in +some tumor types, including prostate adenocarcinoma, lung adenocarcinoma +and HR+/HER2+ breast ductal carcinoma, but not in others, such as +colorectal MSS, pancreatic adenocarcinoma and high-grade serous ovarian +cancer. We also identified specific somatic alterations associated with +increased metastatic burden and specific routes of metastatic spread. +Our data offer a unique resource for the investigation of the biologic +basis for metastatic spread and highlight the crucial role of +chromosomal instability in cancer progression + + +TRUE + + + + +0 + + +2023-10-20 08:24:52 + + +25775 + + +TRUE + + +msk_met_2021 + + +mixed + + +hg19 + + +35120664 + + +Nguyen et al. Cell 2022 + + +FALSE + + +TRUE + + + + +Cervical Cancer (MSK, Clin Cancer Res 2023) + + +Targeted Sequencing of 177 cervical tumors and their matched normal +samples via MSK-IMPACT. + + +TRUE + + + + +0 + + +2023-10-25 08:26:25 + + +177 + + +TRUE + + +cervix_msk_2023 + + +cervix + + +hg19 + + +37643132 + + +Friedman et al. Clin Cancer Res 2023 + + +NA + + +NA + + + + +Mature T and NK Neoplasms (MSK, Blood Adv 2023) + + +Targeted sequencing of 132 Mature T and NK Neoplasms and their matched +normals via MSK-IMPACT. + + +TRUE + + + + +0 + + +2023-10-25 17:28:44 + + +132 + + +TRUE + + +mtnn_msk_2022 + + +mtnn + + +hg19 + + +37078708 + + +William T et al. Blood Adv 2023 + + +FALSE + + +FALSE + + + + Bladder Cancer (MSK, Clin Cancer Research 2023) Targeted Sequencing of 526 bladder tumors and their matched normals via -MSK-IMPACT +MSK-IMPACT. TRUE @@ -18925,7 +19015,7 @@

cBioPortalData() && cBioDataPack()< 0 -2023-08-24 08:02:48 +2023-10-25 17:55:22 526 @@ -18943,10 +19033,10 @@

cBioPortalData() && cBioDataPack()< hg19 -NA +37682528 -NA +Guercio et al. Clin Cancer Res. 2023 NA @@ -18957,58 +19047,59 @@

cBioPortalData() && cBioDataPack()< -Endometrial Carcinoma Ancestry (MSK, Cancer Discovery 2023) +Non-Small Cell Lung Cancer (MSK, Science 2015) -Targeted sequencing of 1882 Endometrial Cancer tumor and normal pairs -via MSK-IMPACT. +Whole-exome sequencing of tumor-normal tissue pairs from 16 non-small +cell lung cancer samples. TRUE +PUBLIC 0 -2023-09-01 08:02:50 +2023-10-27 19:55:27 -1882 +16 TRUE -ucec_ancestry_cds_msk_2023 +nsclc_mskcc_2015 -ucec +nsclc hg19 -NA +25765070 -NA +Rivzi et al. Science 2016 -NA +TRUE -NA +TRUE -Esophageal/Stomach Cancer (MSK, 2023) +Pancreatic Neuroendocrine Tumors (MSK, 2023) -Targeted sequencing of 902 Esophageal/stomach cancer patients via -MSK-IMPACT. +Targeted sequencing of 65 Pancreatic Neuroendocrine tumors/normal pairs +via MSK-IMPACT. TRUE @@ -19019,19 +19110,19 @@

cBioPortalData() && cBioDataPack()< 0 -2023-09-05 16:02:41 +2023-10-31 08:25:43 -902 +65 TRUE -egc_msk_2023 +panet_msk_erc_2023 -stomach +pancreas hg19 @@ -19051,34 +19142,36 @@

cBioPortalData() && cBioDataPack()< -MSK-IMPACT Heme Tumors (MSK, 2022) +Breast Invasive Carcinoma (TCGA, Firehose Legacy) -Targeted sequencing of 2383 myeloid and lymphoid neoplasms and their -matched normals via MSK-IMPACT Heme panel. +TCGA Breast Invasive Carcinoma. Source data from +GDAC +Firehose. Previously known as TCGA Provisional. TRUE +PUBLIC 0 -2023-09-08 16:02:51 +2023-11-09 17:45:45 -2383 +1108 TRUE -heme_msk_impact_2022 +brca_tcga -mixed +brca hg19 @@ -19090,10 +19183,10 @@

cBioPortalData() && cBioDataPack()< NA -NA +TRUE -NA +TRUE @@ -19112,7 +19205,7 @@

cBioPortalData() && cBioDataPack()< 0 -2023-09-23 08:22:12 +2023-11-14 17:23:37 322 diff --git a/authors.html b/authors.html index fcdda18..5ba2e64 100644 --- a/authors.html +++ b/authors.html @@ -97,15 +97,16 @@

Citation

Ramos M, Waldron L (2023). MultiAssayWorkshop: Multi-omic Integration and Analysis of cBioPortal and TCGA data with MultiAssayExperiment. -https://waldronlab.github.io/MultiAssayWorkshop/, -docker.io/mr148/multiassayworkshop. +R package version 3.18.0, +docker.io/mr148/multiassayworkshop, https://waldronlab.github.io/MultiAssayWorkshop/.

@Manual{,
   title = {MultiAssayWorkshop: Multi-omic Integration and Analysis of cBioPortal and TCGA data with MultiAssayExperiment},
   author = {Marcel Ramos and Levi Waldron},
   year = {2023},
-  note = {https://waldronlab.github.io/MultiAssayWorkshop/,
+  note = {R package version 3.18.0, 
 docker.io/mr148/multiassayworkshop},
+  url = {https://waldronlab.github.io/MultiAssayWorkshop/},
 }
diff --git a/pkgdown.yml b/pkgdown.yml index fd35e25..d5b0b55 100644 --- a/pkgdown.yml +++ b/pkgdown.yml @@ -7,7 +7,7 @@ articles: TCGAutilsCheatsheet: TCGAutilsCheatsheet.html cBioPortal_Studies: cBioPortal_Studies.html curatedTCGAData_ref: curatedTCGAData_ref.html -last_built: 2023-09-26T15:58Z +last_built: 2023-11-21T17:37Z urls: reference: https://waldronlab.io/MultiAssayWorkshop/reference article: https://waldronlab.io/MultiAssayWorkshop/articles