A collection of functions for Q matrix manipulations.
SCALCS project is pure Python implementations of Q-Matrix formalisms for ion channel research. To learn more about kinetic analysis of ion channels see the references below.
CH82: Colquhoun D, Hawkes AG (1982) On the stochastic properties of bursts of single ion channel openings and of clusters of bursts. Phil Trans R Soc Lond B 300, 1-59.
HJC92: Hawkes AG, Jalali A, Colquhoun D (1992) Asymptotic distributions of apparent open times and shut times in a single channel record allowing for the omission of brief events. Phil Trans R Soc Lond B 337, 383-404.
CH95a: Colquhoun D, Hawkes AG (1995a) The principles of the stochastic interpretation of ion channel mechanisms. In: Single-channel recording. 2nd ed. (Eds: Sakmann B, Neher E) Plenum Press, New York, pp. 397-482.
CH95b: Colquhoun D, Hawkes AG (1995b) A Q-Matrix Cookbook. In: Single-channel recording. 2nd ed. (Eds: Sakmann B, Neher E) Plenum Press, New York, pp. 589-633.
CHS96: Colquhoun D, Hawkes AG, Srodzinski K (1996) Joint distributions of apparent open and shut times of single-ion channels and maximum likelihood fitting of mechanisms. Phil Trans R Soc Lond A 354, 2555-2590.