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Simulation of signal propagation between MCUs in the human brain

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BrainSimulation

Simulation of the human brain.

How to build

Linux

  1. Clone the repository.

  2. From the working directory root run

    $ make

  3. The makefile supports the install target (optional).

Windows

  1. Clone the repository.
  2. Open win32\win32.sln in Visual Studio.
  3. Build using Visual Studio

Customizing the build

You can customize the build by passing Preprocessor options. Using make, pass them to the DFLAGS variable. Use GCC's regular -D switch.

Example, sets the THREADFACTOR directive to 0.5 using GCCs -D switch:

$ make DFLAGS="-DTHREADFACTOR=0.5"

Available switches:

  • THREADFACTOR: Factor to multiple the logical corecount with in order to determine the number of threads. May be a floating point number (0.5 is a common option). Default = 1.
  • MULTITHREADING: Set to 0 to turn multithreading off and only use a single thread. Default = 1.

Available function modificators:

  • D_NEIGHBORFACTOR: Ratio of how much the direct neighbors influence the energy state of any node. This is a factor multiplied with the direct neighbor-energy. Usually a number in (0,1], however numbers > 1 are possible. Default = 1.
  • ID_NEIGHBORFACTOR: Ratio of how much the indirect neighbors influence the energy state of any node. This is a factor multiplied with the indirect neighbor-energy. Usually a number in (0,1], however numbers > 1 are possible. Default = 1.
  • ENERGY_FACTOR: Ratio of how much the historical energy state negatively influences the current energy slope. This is a factor multiplied with the historical energy. Usually a number in (0,1], however numbers > 1 are possible. Default = 1.
  • ENERGY_WEIGHT: Ratio of how much the historical energy state influences the current energy state. This is a factor multiplied with the historical energy. Usually a number in (0,1], however numbers > 1 are possible. Default = 1.
  • DELTA_FACTOR: Ratio of how much the current slope vector influences the slope calculation. This is a factor multiplied with the current slope vector. Usually a number in (0,1], however numbers > 1 are possible. Default = 1.
  • SLOPE_FACTOR: Ratio of how much the historical slope influences the current energy state. This is a factor multiplied with the historical slope. Usually a number in (0,1], however numbers > 1 are possible. Default = 1.
  • SLOPE_WEIGHT: Ratio of how much the current calculated slope influences the current energy state. This is a factor multiplied with the slope. Usually a number in (0,1], however numbers > 1 are possible. Default = 1.

These factors can be configured during compilation to customize the behavior of each node during the simulation.

How to run

  1. Create a ./testoutput directory in the directory from which you execute the brainsimulation. Results will be written to this directory.
  2. (Optional) Configure inputs bitmap image files
  3. Execute the simulation in one of the following ways:
  • Linux, running from the build directory:

    $ ./brainsimulation -x X_NODES -y Y_NODES --ticks SIMULATION_TICKS [OPTIONAL PARAMETERS]

  • Linux, after compiling using make install:

    $ brainsimulation -x X_NODES -y Y_NODES --ticks SIMULATION_TICKS [OPTIONAL PARAMETERS]

  • Windows:

    > .\brainsimulation -x X_NODES -y Y_NODES --ticks SIMULATION_TICKS [OPTIONAL PARAMETERS]

Command Line Parameters

Command line parameters are also shown when starting the brainsimulation with brainsimulation --help.

Generally, run with: brainsimulation -x X_NODES -y Y_NODES --ticks SIMULATION_TICKS [OPTIONAL PARAMETERS]

Mandatory parameters:

  • -x X_NODES: Size of the simulated node grid on the X axis. Single integer parameter.
  • -y Y_NODES: Size of the simulated node grid on the Y axis. Single integer parameter.
  • --ticks SIMULATION_TICKS: Number of time ticks to simulate. Single integer parameter.

Recommended parameters (technically optional, but doesn't really make sense not to use them):

  • --xobs OBS_X_INDICES: X indices of the observed nodes. One or multiple integer parameters.
  • --yobs OBS_Y_INDICES: Y indices of the observed nodes. One or multiple integer parameters. Must have the same number of parameters as --xobs.

Optional parameters:

  • --allobs: Observes all nodes instead of only a few specified nodes. Causes --xobs and --yobs to be ignored (can thus be ommited). Needs no additional parameters.
    WARNING: Leads to very slow execution times and comsumes a lot of disk space for result files. Use only when absolutely needed.
  • --startlevels STARTING_ENERGY_LEVELS: Initial energy levels of nodes with starting energy. One or multiple floating point parameters.
  • --startx STARTING_ENERGY_X_INDICES: X indices of nodes with starting energy. One or multiple integer parameters. Must have the same number of parameters as --startlevels.
  • --starty STARTING_ENERGY_Y_INDICES: Y indices of nodes with starting energy. One or multiple integer parameters. Must have the same number of parameters as --startlevels.
  • --freqs FREQUENCIES Frequencies of nodes generating energy using sin-frequencies. One or multiple integer parameters. Cannot be used together with --freqbitmaps and its associated flags.
  • --freqx FREQUENCY_NODES_X_INDICES: X indices of nodes generating energy using frequencies. One or multiple integer parameters. Must have the same number of parameters as --freqs.
  • --freqy STARTING_ENERGY_Y_INDICES: Y indices of nodes generating energy using frequencies. One or multiple integer parameters. Must have the same number of parameters as --freqs.
  • --freqbitmaps FILENAMES: File paths of bitmap images to be used for specifying sin-frequencies. Bitmaps must be uncompressed 24-bit bitmaps (MS-Paint default). When using multiple bitmaps, they must all have the same dimensions. Cannot be used together with --freqs and its associated flags. One or multiple parameters.
  • --minbitmapfreq MIN_FREQUENCY: The minimum frequency to generate, mapped to the minimum non-0 bitmap color (1). Single integer parameter.
  • --maxbitmapfreq MAX_FREQUENCY: The maximum frequency to generate, mapped to the maximum bitmap color (765). Single integer parameter.
  • --bitmapduration DURATION_TICKS: The generation duration (in ticks) for a bitmap's signal (analogous to a frame's duration in a movie). Single integer parameter.

Example:

brainsimulation -x 200 -y 200 --ticks 5000 --xobs 50 51 --yobs 50 51 --startlevels 10 11 --startx 10 11 --starty 10 11 --freqs 3 5 --freqx 25 26 --freqy 25 26

Example using bitmaps:

brainsimulation -x 200 -y 200 --ticks 3000 --xobs 50 51 --yobs 50 51 --freqbitmaps testinput/input0.bmp testinput/input1.bmp testinput/input2.bmp --minbitmapfreq 10 --maxbitmapfreq 40 --bitmapduration 1000

Using Bitmap Images as Inputs

You can choose to use bitmap images as inputs and pass them using the --freqbitmaps paramter. Doing this will generate input timeseries for all non-zero (non-black) pixels from the specified 24-bit bitmap images. Each pixel will be directly mapped to the corresponding node in the simulation (using its x and y coordinates, with 0,0 at the top left). Bitmaps must have the same dimensions and must be encoded using uncompressed, 24-bit bitmap files, which is the MS-Paint default. Bitmap color values are summed (R+G+B) and translated to frequencies. The minimum non-0 color (1) is mapped to the value provided using --minbitmapfreq and the maximum color (765) is mapped to the value provided using --maxbitmapfreq. Other frequencies are determined using linear interpolation. A black (value 0) pixel will always be interpreted as a pixel that is currently not generating a signal.

You can specify multiple images. Each image is shown for the duration specified using --bitmapduration (in ticks). Once its duration is up, the next image is used for generation (analogous to a frame in a movie). The simulation loop over the bitmaps in case the the total simulation duration exceeds the duration of the bitmap "movie".

Developing

Check out our code documentation at https://descartesresearch.github.io/BrainSimulation/

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