Double Decoupling Method (DDM) ddm allows binding free energy for a complex, using the double decoupling method. Free software: Documentation and installation instructions: https://ddm-docs.readthedocs.io. What does ddm ? Modeling bla bla bla Solvate bound state Solvate unbound state Pick reference Monitor colective variables Confine bound state Vba bound state Alchemical bound state Confine unbound state Vba unbound state Alchemical unbound state Total