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Lithium + Cocaine #129

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Apr 11, 2024
Merged

Lithium + Cocaine #129

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22a31e9
Lithium + Cocaine
LunaUrsa Apr 7, 2024
06c27f5
Merge https://github.com/TripSit/drugs into LunaUrsa/issue101
LunaUrsa Apr 10, 2024
b0aeec2
Merge branch 'main' of https://github.com/TripSit/drugs into LunaUrsa…
LunaUrsa Apr 10, 2024
051b07c
Merge branch 'main' into LunaUrsa/issue101
LunaUrsa Apr 10, 2024
69d5cb2
Merge branch 'main' into LunaUrsa/issue101
LunaUrsa Apr 11, 2024
1feac44
Lithium + Cocaine
LunaUrsa Apr 11, 2024
c6f155e
Merge with main
LunaUrsa Apr 11, 2024
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32 changes: 32 additions & 0 deletions combos.json
View file
Open in desktop
Original file line number Diff line number Diff line change
Expand Up @@ -1072,6 +1072,22 @@
"note": "No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.",
"status": "Caution"
},
"lithium": {
"note": "Lithium may inhibit some of the recreational effects of cocaine.",
"sources": [
{
"author": "Flemenbaum, A.",
"title": "Antagonism of behavioral effects of cocaine by lithium. (1977)",
"url": "https://doi.org/10.1016/0091-3057(77)90015-6"
},
{
"author": "Cronson, A. J., & Flemenbaum, A.",
"title": "Antagonism of Cocaine Highs by Lithium. (1981)",
"url": "https://doi.org/10.1007/978-1-4684-3614-3_132"
}
],
"status": "Low Risk & Decrease"
},
"lsd": {
"note": "Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences",
"status": "Caution"
Expand Down Expand Up @@ -1902,6 +1918,22 @@
],
"status": "Dangerous"
},
"cocaine": {
"note": "Lithium may inhibit some of the recreational effects of cocaine.",
"sources": [
{
"author": "Flemenbaum, A.",
"title": "Antagonism of behavioral effects of cocaine by lithium. (1977)",
"url": "https://doi.org/10.1016/0091-3057(77)90015-6"
},
{
"author": "Cronson, A. J., & Flemenbaum, A.",
"title": "Antagonism of Cocaine Highs by Lithium. (1981)",
"url": "https://doi.org/10.1007/978-1-4684-3614-3_132"
}
],
"status": "Low Risk & Decrease"
},
"dmt": {
"note": "There is a large number of reports indicating a high seizure and psychosis risk from this combination.",
"sources": [
Expand Down
114 changes: 32 additions & 82 deletions drugs.json
View file
Open in desktop
Original file line number Diff line number Diff line change
Expand Up @@ -15332,6 +15332,22 @@
"note": "No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.",
"status": "Caution"
},
"lithium": {
"note": "Lithium may inhibit some of the recreational effects of cocaine.",
"sources": [
{
"author": "Flemenbaum, A.",
"title": "Antagonism of behavioral effects of cocaine by lithium. (1977)",
"url": "https://doi.org/10.1016/0091-3057(77)90015-6"
},
{
"author": "Cronson, A. J., & Flemenbaum, A.",
"title": "Antagonism of Cocaine Highs by Lithium. (1981)",
"url": "https://doi.org/10.1007/978-1-4684-3614-3_132"
}
],
"status": "Low Risk & Decrease"
},
"lsd": {
"note": "Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences",
"status": "Caution"
Expand Down Expand Up @@ -16956,47 +16972,6 @@
},
"tramadol": {
"status": "Dangerous"
},
"mephedrone": {
"note": "Risk of serotonin syndrome as both drugs raise serotonin levels. In addition to concerns of high blood pressure and unnecessary strain on the heart. As well as potentially causing anxiety and greater physical discomfort due to the combination.",
"sources": [
{
"author": "J Kehr, F Ichinose, S Yoshitake, M Goiny, T Sievertsson, F Nyberg, T Yoshitake",
"title": "Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats",
"url": "https://doi.org/10.1111/j.1476-5381.2011.01499.x"
},
{
"author": "Gregory C. Hadlock, Katy M. Webb, Lisa M. McFadden, Pei Wen Chu, Jonathan D. Ellis, Scott C. Allen, David M. Andrenyak, Paula L. Vieira-Brock, Christopher L. German, Kevin M. Conrad, Amanda J. Hoonakker, James W. Gibb, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein",
"title": "4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse",
"url": "https://doi.org/10.1124/jpet.111.184119 "
},
{
"author": "Anna R. Schwartz, Anthony F. Pizon & Daniel E. Brooks",
"title": "Dextromethorphan-induced serotonin syndrome",
"url": "https://doi.org/10.1080/15563650701668625"
},
{
"author": "DrugBank",
"title": "Dextromethorphan",
"url": "https://go.drugbank.com/drugs/DB00514"
},
{
"author": "Henderson MG, Fuller RW",
"title": "Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats",
"url": "https://doi.org/10.1016/0006-8993(92)91144-4"
},
{
"author": "Reissig CJ, Carter LP, Johnson MW, Mintzer MZ, Klinedinst MA, Griffiths RR",
"title": "High doses of dextromethorphan, an NMDA antagonist, produce effects similar to classic hallucinogens ",
"url": "https://doi.org/10.1007/s00213-012-2680-6"
},
{
"author": "Meng H, Cao J, Kang J, Ying X, Ji J, Reynolds W, Rampe D.",
"title": "Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat ",
"url": "https://doi.org/10.1016/j.toxlet.2011.10.010"
}
],
"status": "Dangerous"
}
},
"dose_note": " NOTE: See http://dxm.tripsit.me for mg/lb doses, among other things. Deaths have been reported at 25mg/kg",
Expand Down Expand Up @@ -23396,6 +23371,22 @@
],
"status": "Dangerous"
},
"cocaine": {
"note": "Lithium may inhibit some of the recreational effects of cocaine.",
"sources": [
{
"author": "Flemenbaum, A.",
"title": "Antagonism of behavioral effects of cocaine by lithium. (1977)",
"url": "https://doi.org/10.1016/0091-3057(77)90015-6"
},
{
"author": "Cronson, A. J., & Flemenbaum, A.",
"title": "Antagonism of Cocaine Highs by Lithium. (1981)",
"url": "https://doi.org/10.1007/978-1-4684-3614-3_132"
}
],
"status": "Low Risk & Decrease"
},
"dmt": {
"note": "There is a large number of reports indicating a high seizure and psychosis risk from this combination.",
"sources": [
Expand Down Expand Up @@ -25592,47 +25583,6 @@
"empathogen"
],
"combos": {
"dextromethorphan": {
"note": "Risk of serotonin syndrome as both drugs raise serotonin levels. In addition to concerns of high blood pressure and unnecessary strain on the heart. As well as potentially causing anxiety and greater physical discomfort due to the combination.",
"sources": [
{
"author": "J Kehr, F Ichinose, S Yoshitake, M Goiny, T Sievertsson, F Nyberg, T Yoshitake",
"title": "Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats",
"url": "https://doi.org/10.1111/j.1476-5381.2011.01499.x"
},
{
"author": "Gregory C. Hadlock, Katy M. Webb, Lisa M. McFadden, Pei Wen Chu, Jonathan D. Ellis, Scott C. Allen, David M. Andrenyak, Paula L. Vieira-Brock, Christopher L. German, Kevin M. Conrad, Amanda J. Hoonakker, James W. Gibb, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein",
"title": "4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse",
"url": "https://doi.org/10.1124/jpet.111.184119 "
},
{
"author": "Anna R. Schwartz, Anthony F. Pizon & Daniel E. Brooks",
"title": "Dextromethorphan-induced serotonin syndrome",
"url": "https://doi.org/10.1080/15563650701668625"
},
{
"author": "DrugBank",
"title": "Dextromethorphan",
"url": "https://go.drugbank.com/drugs/DB00514"
},
{
"author": "Henderson MG, Fuller RW",
"title": "Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats",
"url": "https://doi.org/10.1016/0006-8993(92)91144-4"
},
{
"author": "Reissig CJ, Carter LP, Johnson MW, Mintzer MZ, Klinedinst MA, Griffiths RR",
"title": "High doses of dextromethorphan, an NMDA antagonist, produce effects similar to classic hallucinogens ",
"url": "https://doi.org/10.1007/s00213-012-2680-6"
},
{
"author": "Meng H, Cao J, Kang J, Ying X, Ji J, Reynolds W, Rampe D.",
"title": "Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat ",
"url": "https://doi.org/10.1016/j.toxlet.2011.10.010"
}
],
"status": "Dangerous"
},
"dextromethorphan": {
"note": "Risk of serotonin syndrome as both drugs raise serotonin levels. In addition to concerns of high blood pressure and unnecessary strain on the heart. As well as potentially causing anxiety and greater physical discomfort due to the combination.",
"sources": [
Expand Down
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