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4mmc + MDMA #138

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4mmc + MDMA #138

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Merge branch 'main' of https://github.com/TripSit/drugs into LunaUrsa…
LunaUrsa Apr 11, 2024
1e17b35
4mmc + MDMA
LunaUrsa Apr 11, 2024
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92 changes: 92 additions & 0 deletions combos.json
View file
Open in desktop
Original file line number Diff line number Diff line change
Expand Up @@ -2583,6 +2583,52 @@
"note": "MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAO-A inhibitors with MDMA will lead to hypertensive crises.",
"status": "Dangerous"
},
"mephedrone": {
"note": "Risk of serotonin syndrome as both drugs raise serotonin levels. Stimulants also increase the neurotoxic effects of MDMA, in addition to concerns of high blood pressure and unnecessary strain on the heart. As well as potentially causing anxiety and greater physical discomfort due to the combination.",
"sources": [
{
"author": "J Kehr, F Ichinose, S Yoshitake, M Goiny, T Sievertsson, F Nyberg, T Yoshitake",
"title": "Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats",
"url": "https://doi.org/10.1111/j.1476-5381.2011.01499.x"
},
{
"author": "Gregory C. Hadlock, Katy M. Webb, Lisa M. McFadden, Pei Wen Chu, Jonathan D. Ellis, Scott C. Allen, David M. Andrenyak, Paula L. Vieira-Brock, Christopher L. German, Kevin M. Conrad, Amanda J. Hoonakker, James W. Gibb, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein",
"title": "4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse",
"url": "https://doi.org/10.1124/jpet.111.184119 "
},
{
"author": "Gough B, Ali SF, Slikker W Jr, Holson RR. ",
"title": "Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate. (1991)",
"url": "https://doi.org/10.1016/0091-3057(91)90137-q"
},
{
"author": "Schmidt CJ, Levin JA, Lovenberg W. ",
"title": "In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain. (1987)",
"url": "https://doi.org/10.1016/0006-2952(87)90729-5"
},
{
"author": "Bankson MG, Cunningham KA.",
"title": "3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions. (2001)",
"url": "https://pubmed.ncbi.nlm.nih.gov/11356903/"
},
{
"author": "A.C. Parrott",
"title": "Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity (2002)",
"url": "https://doi.org/10.1016/S0091-3057(01)00711-0"
},
{
"author": "Lisa H. Gold & George F. Koob ",
"title": "MDMA produces stimulant-like conditioned locomotor activity. (1989)",
"url": "https://doi.org/10.1007/BF00445556"
},
{
"author": "Meng H, Cao J, Kang J, Ying X, Ji J, Reynolds W, Rampe D.",
"title": "Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat ",
"url": "https://doi.org/10.1016/j.toxlet.2011.10.010"
}
],
"status": "Dangerous"
},
"mescaline": {
"status": "Low Risk & Synergy"
},
Expand Down Expand Up @@ -2655,6 +2701,52 @@
}
],
"status": "Dangerous"
},
"mdma": {
"note": "Risk of serotonin syndrome as both drugs raise serotonin levels. Stimulants also increase the neurotoxic effects of MDMA, in addition to concerns of high blood pressure and unnecessary strain on the heart. As well as potentially causing anxiety and greater physical discomfort due to the combination.",
"sources": [
{
"author": "J Kehr, F Ichinose, S Yoshitake, M Goiny, T Sievertsson, F Nyberg, T Yoshitake",
"title": "Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats",
"url": "https://doi.org/10.1111/j.1476-5381.2011.01499.x"
},
{
"author": "Gregory C. Hadlock, Katy M. Webb, Lisa M. McFadden, Pei Wen Chu, Jonathan D. Ellis, Scott C. Allen, David M. Andrenyak, Paula L. Vieira-Brock, Christopher L. German, Kevin M. Conrad, Amanda J. Hoonakker, James W. Gibb, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein",
"title": "4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse",
"url": "https://doi.org/10.1124/jpet.111.184119 "
},
{
"author": "Gough B, Ali SF, Slikker W Jr, Holson RR. ",
"title": "Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate. (1991)",
"url": "https://doi.org/10.1016/0091-3057(91)90137-q"
},
{
"author": "Schmidt CJ, Levin JA, Lovenberg W. ",
"title": "In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain. (1987)",
"url": "https://doi.org/10.1016/0006-2952(87)90729-5"
},
{
"author": "Bankson MG, Cunningham KA.",
"title": "3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions. (2001)",
"url": "https://pubmed.ncbi.nlm.nih.gov/11356903/"
},
{
"author": "A.C. Parrott",
"title": "Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity (2002)",
"url": "https://doi.org/10.1016/S0091-3057(01)00711-0"
},
{
"author": "Lisa H. Gold & George F. Koob ",
"title": "MDMA produces stimulant-like conditioned locomotor activity. (1989)",
"url": "https://doi.org/10.1007/BF00445556"
},
{
"author": "Meng H, Cao J, Kang J, Ying X, Ji J, Reynolds W, Rampe D.",
"title": "Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat ",
"url": "https://doi.org/10.1016/j.toxlet.2011.10.010"
}
],
"status": "Dangerous"
}
},
"mescaline": {
Expand Down
92 changes: 92 additions & 0 deletions drugs.json
View file
Open in desktop
Original file line number Diff line number Diff line change
Expand Up @@ -24844,6 +24844,52 @@
"note": "MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAO-A inhibitors with MDMA will lead to hypertensive crises.",
"status": "Dangerous"
},
"mephedrone": {
"note": "Risk of serotonin syndrome as both drugs raise serotonin levels. Stimulants also increase the neurotoxic effects of MDMA, in addition to concerns of high blood pressure and unnecessary strain on the heart. As well as potentially causing anxiety and greater physical discomfort due to the combination.",
"sources": [
{
"author": "J Kehr, F Ichinose, S Yoshitake, M Goiny, T Sievertsson, F Nyberg, T Yoshitake",
"title": "Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats",
"url": "https://doi.org/10.1111/j.1476-5381.2011.01499.x"
},
{
"author": "Gregory C. Hadlock, Katy M. Webb, Lisa M. McFadden, Pei Wen Chu, Jonathan D. Ellis, Scott C. Allen, David M. Andrenyak, Paula L. Vieira-Brock, Christopher L. German, Kevin M. Conrad, Amanda J. Hoonakker, James W. Gibb, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein",
"title": "4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse",
"url": "https://doi.org/10.1124/jpet.111.184119 "
},
{
"author": "Gough B, Ali SF, Slikker W Jr, Holson RR. ",
"title": "Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate. (1991)",
"url": "https://doi.org/10.1016/0091-3057(91)90137-q"
},
{
"author": "Schmidt CJ, Levin JA, Lovenberg W. ",
"title": "In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain. (1987)",
"url": "https://doi.org/10.1016/0006-2952(87)90729-5"
},
{
"author": "Bankson MG, Cunningham KA.",
"title": "3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions. (2001)",
"url": "https://pubmed.ncbi.nlm.nih.gov/11356903/"
},
{
"author": "A.C. Parrott",
"title": "Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity (2002)",
"url": "https://doi.org/10.1016/S0091-3057(01)00711-0"
},
{
"author": "Lisa H. Gold & George F. Koob ",
"title": "MDMA produces stimulant-like conditioned locomotor activity. (1989)",
"url": "https://doi.org/10.1007/BF00445556"
},
{
"author": "Meng H, Cao J, Kang J, Ying X, Ji J, Reynolds W, Rampe D.",
"title": "Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat ",
"url": "https://doi.org/10.1016/j.toxlet.2011.10.010"
}
],
"status": "Dangerous"
},
"mescaline": {
"status": "Low Risk & Synergy"
},
Expand Down Expand Up @@ -25623,6 +25669,52 @@
}
],
"status": "Dangerous"
},
"mdma": {
"note": "Risk of serotonin syndrome as both drugs raise serotonin levels. Stimulants also increase the neurotoxic effects of MDMA, in addition to concerns of high blood pressure and unnecessary strain on the heart. As well as potentially causing anxiety and greater physical discomfort due to the combination.",
"sources": [
{
"author": "J Kehr, F Ichinose, S Yoshitake, M Goiny, T Sievertsson, F Nyberg, T Yoshitake",
"title": "Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats",
"url": "https://doi.org/10.1111/j.1476-5381.2011.01499.x"
},
{
"author": "Gregory C. Hadlock, Katy M. Webb, Lisa M. McFadden, Pei Wen Chu, Jonathan D. Ellis, Scott C. Allen, David M. Andrenyak, Paula L. Vieira-Brock, Christopher L. German, Kevin M. Conrad, Amanda J. Hoonakker, James W. Gibb, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein",
"title": "4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse",
"url": "https://doi.org/10.1124/jpet.111.184119 "
},
{
"author": "Gough B, Ali SF, Slikker W Jr, Holson RR. ",
"title": "Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate. (1991)",
"url": "https://doi.org/10.1016/0091-3057(91)90137-q"
},
{
"author": "Schmidt CJ, Levin JA, Lovenberg W. ",
"title": "In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain. (1987)",
"url": "https://doi.org/10.1016/0006-2952(87)90729-5"
},
{
"author": "Bankson MG, Cunningham KA.",
"title": "3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions. (2001)",
"url": "https://pubmed.ncbi.nlm.nih.gov/11356903/"
},
{
"author": "A.C. Parrott",
"title": "Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity (2002)",
"url": "https://doi.org/10.1016/S0091-3057(01)00711-0"
},
{
"author": "Lisa H. Gold & George F. Koob ",
"title": "MDMA produces stimulant-like conditioned locomotor activity. (1989)",
"url": "https://doi.org/10.1007/BF00445556"
},
{
"author": "Meng H, Cao J, Kang J, Ying X, Ji J, Reynolds W, Rampe D.",
"title": "Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat ",
"url": "https://doi.org/10.1016/j.toxlet.2011.10.010"
}
],
"status": "Dangerous"
}
},
"formatted_aftereffects": {
Expand Down
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