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Prioritization of genetic regions based on cohort (case vs control) using association testing

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excalibur_simulations

This repository contains all the necessary codes to reproduce the preliminary test selection and the simulations used to establish our ensemble method Excalibur

Preliminary test selection

  • All the code used to perform the preliminary tests selection
  • The folder results contains all the intermediate results from the preliminary selection steps

Numerical experiments and simulations design

  • Input data from COSI contains the data simulated via COSI program
  • Raw R results from simulations contains R data results for the 18 power experiments and 9 type I error experiments obtained thanks to the simulation pipeline
  • All the necessary functions to run the simulation pipeline (that can be launch via script_general_simulation.R

Excalibur.R is the function to use our proposed optimal ensemble method based on a combination of 33 aggregation tests

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Prioritization of genetic regions based on cohort (case vs control) using association testing

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