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Resubmission w/ duplicated path IDs removed.
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The following paths were duplicated in the first attempt:

- DB01137_MESH_D018410_1
- DB01137_MESH_D011023_1
- DB01369_MESH_D013290_1

They have now been removed.
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dede2021 authored Jun 6, 2021
1 parent 156e41a commit 11ed1b5
Showing 1 changed file with 0 additions and 173 deletions.
173 changes: 0 additions & 173 deletions submission.yaml
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reference:
- https://en.wikipedia.org/wiki/Luseogliflozin
- https://en.wikipedia.org/wiki/SGLT2_inhibitor
- directed: true
graph:
_id: DB01137_MESH_D018410_1
disease: Bacterial pneumonia
disease_mesh: MESH:D018410
drug: levofloxacin
drug_mesh: MESH:D064704
drugbank: DB:DB01137
links:
- key: negatively regulates
source: MESH:D064704
target: InterPro:IPR035516
- key: negatively regulates
source: MESH:D064704
target: InterPro:IPR013760
- key: positively regulates
source: InterPro:IPR035516
target: GO:0006260
- key: positively regulates
source: InterPro:IPR013760
target: GO:0006260
- key: in taxon
source: GO:0006260
target: NCBITaxon:1392
- key: causes
source: NCBITaxon:1392
target: MESH:D018410
multigraph: true
nodes:
- id: MESH:D064704
label: Drug
name: levofloxacin
- id: InterPro:IPR035516
label: GeneFamily
name: DNA gyrase/topoisomerase IV, subunit A, C-terminal
- id: InterPro:IPR013760
label: GeneFamily
name: DNA topoisomerase, type IIA-like domain superfamily
- id: GO:0006260
label: BiologicalProcess
name: Bacterial DNA replication
- id: NCBITaxon:1392
label: OrganismTaxon
name: Bacillus anthracis
- id: MESH:D018410
label: Disease
name: Bacterial pneumonia
reference:
- https://go.drugbank.com/drugs/DB01137#mechanism-of-action
- https://en.wikipedia.org/wiki/Bacterial_pneumonia#Types
- https://en.wikipedia.org/wiki/Levofloxacin#Mechanism_of_action
comment: Different bacterial species can cause pneumonia, the most frequent ones are Streptococcus pneumoniae, Staphylococcus aureus, and Bacillus anthracis, among the gram-positive types of bacteria. Gram-negative examples of bacteria causing pneumonia are Haemophilus influenzae, Klebsiella pneumoniae and Escherichia coli.
- directed: true
graph:
_id: DB01137_MESH_D011023_1
disease: Staphylococcal pneumonia
disease_mesh: MESH:D011023
drug: levofloxacin
drug_mesh: MESH:D064704
drugbank: DB:DB01137
links:
- key: negatively regulates
source: MESH:D064704
target: InterPro:IPR035516
- key: negatively regulates
source: MESH:D064704
target: InterPro:IPR013760
- key: positively regulates
source: InterPro:IPR035516
target: GO:0006260
- key: positively regulates
source: InterPro:IPR013760
target: GO:0006260
- key: in taxon
source: GO:0006260
target: NCBITaxon:1280
- key: causes
source: NCBITaxon:1280
target: MESH:D011023
multigraph: true
nodes:
- id: MESH:D064704
label: Drug
name: levofloxacin
- id: InterPro:IPR035516
label: GeneFamily
name: DNA gyrase/topoisomerase IV, subunit A, C-terminal
- id: InterPro:IPR013760
label: GeneFamily
name: DNA topoisomerase, type IIA-like domain superfamily
- id: GO:0006260
label: BiologicalProcess
name: Bacterial DNA replication
- id: NCBITaxon:1280
label: OrganismTaxon
name: Staphylococcus aureus
- id: MESH:D011023
label: Disease
name: Staphylococcal pneumonia
reference:
- https://go.drugbank.com/drugs/DB01137#mechanism-of-action
- https://en.wikipedia.org/wiki/Bacterial_pneumonia#Gram-positive
- https://en.wikipedia.org/wiki/Staphylococcus_aureus#Role_in_disease
- https://en.wikipedia.org/wiki/Levofloxacin#Mechanism_of_action
comment: Different bacterial species can cause pneumonia, the most frequent ones are Streptococcus pneumoniae, Staphylococcus aureus, and Bacillus anthracis, among the gram-positive types of bacteria. Gram-negative examples of bacteria causing pneumonia are Haemophilus influenzae, Klebsiella pneumoniae and Escherichia coli.
- directed: true
graph:
_id: DB01369_MESH_D013290_1
disease: Streptococcus pyogenes infection
disease_mesh: MESH:D013290
drug: quinupristin
drug_mesh: MESH:C113825
drugbank: DB:DB01369
links:
- key: decreases activity of
source: MESH:C113825
target: MESH:D054681
- key: negatively regulates
source: MESH:C113825
target: Pfam:PF00466
- key: negatively regulates
source: MESH:C113825
target: Pfam:PF00237
- key: positively regulates
source: Pfam:PF00466
target: GO:0006412
- key: positively regulates
source: Pfam:PF00237
target: GO:0006412
- key: location of
source: MESH:D054681
target: GO:0000048
- key: positively correlated with
source: GO:0000048
target: GO:0006412
- key: in taxon
source: GO:0006412
target: NCBITaxon:1314
- key: causes
source: NCBITaxon:1314
target: MESH:D013290
multigraph: true
nodes:
- id: MESH:C113825
label: Drug
name: quinupristin
- id: MESH:D054681
label: ChemicalSubstance
name: Ribosome Subunits, Large, Bacterial
- id: GO:0006412
label: BiologicalProcess
name: translation
- id: GO:0000048
label: MolecularActivity
name: peptidyltransferase activity
- id: Pfam:PF00237
label: GeneFamily
name: Ribosomal protein L22p/L17e
- id: Pfam:PF00466
label: GeneFamily
name: Ribosomal protein L10
- id: NCBITaxon:1314
label: OrganismTaxon
name: Streptococcus pyogenes
- id: MESH:D013290
label: Disease
name: Streptococcus pyogenes infection
reference:
- https://go.drugbank.com/drugs/DB01369#mechanism-of-action
- https://en.wikipedia.org/wiki/Quinupristin
- https://www.tandfonline.com/doi/abs/10.1517/13543784.7.4.591
- https://en.wikipedia.org/wiki/Quinupristin/dalfopristin#Mechanism_of_action
comment: This drug is used in combination with dalfopristin. Both interfere with the bacterial protein synthesis, at different stages of the translation. Quinupristin inhibits the late phase of protein synthesis, whereas dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome. In combination, both drugs are more effective than each used individually (https://go.drugbank.com/drugs/DB01369#description).
- directed: true
graph:
_id: DB00461_MESH_D001172_1
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