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Commit from GitHub Actions (Update Indications on Merge)
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AlexT322 committed Dec 4, 2021
1 parent da5881a commit 3b1a5e0
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Showing 3 changed files with 125 additions and 47 deletions.
76 changes: 76 additions & 0 deletions indication_paths.json
Original file line number Diff line number Diff line change
Expand Up @@ -289429,5 +289429,81 @@
"reference": [
"https://go.drugbank.com/drugs/DB09462"
]
},
{
"directed": true,
"graph": {
"_id": "DB00715_MESH_D013313_1",
"disease": "Posttraumatic stress disorder",
"disease_mesh": "MESH:D013313",
"drug": "paroxetine",
"drug_mesh": "MESH:D017374",
"drugbank": "DB:DB00715"
},
"links": [
{
"key": "decreases activity of",
"source": "MESH:D017374",
"target": "UniProt:P31645"
},
{
"key": "positively regulates",
"source": "UniProt:P31645",
"target": "GO:0051610"
},
{
"key": "decreases abundance of",
"source": "GO:0051610",
"target": "MESH:D012701"
},
{
"key": "positively correlated with",
"source": "MESH:D012701",
"target": "GO:0060096"
},
{
"key": "negatively correlated with",
"source": "GO:0060096",
"target": "MESH:D013313"
}
],
"multigraph": true,
"nodes": [
{
"id": "MESH:D017374",
"label": "Drug",
"name": "Paroxetine"
},
{
"id": "UniProt:P31645",
"label": "Protein",
"name": "Sodium-dependent serotonin transporter"
},
{
"id": "GO:0051610",
"label": "BiologicalProcess",
"name": "Serotonin uptake"
},
{
"id": "MESH:D012701",
"label": "ChemicalSubstance",
"name": "Serotonin"
},
{
"id": "GO:0060096",
"label": "BiologicalProcess",
"name": "Serotonin secretion, neurotransmission"
},
{
"id": "MESH:D013313",
"label": "Disease",
"name": "Posttraumatic stress disorder"
}
],
"reference": [
"https://go.drugbank.com/drugs/DB00715#BE0000749",
"https://drugs.ncats.io/drug/41VRH5220H",
"https://en.wikipedia.org/wiki/Post-traumatic_stress_disorder"
]
}
]
48 changes: 48 additions & 0 deletions indication_paths.yaml
Original file line number Diff line number Diff line change
Expand Up @@ -181937,3 +181937,51 @@
name: Constipation
reference:
- https://go.drugbank.com/drugs/DB09462
- directed: true
graph:
_id: DB00715_MESH_D013313_1
disease: Posttraumatic stress disorder
disease_mesh: MESH:D013313
drug: paroxetine
drug_mesh: MESH:D017374
drugbank: DB:DB00715
links:
- key: decreases activity of
source: MESH:D017374
target: UniProt:P31645
- key: positively regulates
source: UniProt:P31645
target: GO:0051610
- key: decreases abundance of
source: GO:0051610
target: MESH:D012701
- key: positively correlated with
source: MESH:D012701
target: GO:0060096
- key: negatively correlated with
source: GO:0060096
target: MESH:D013313
multigraph: true
nodes:
- id: MESH:D017374
label: Drug
name: Paroxetine
- id: UniProt:P31645
label: Protein
name: Sodium-dependent serotonin transporter
- id: GO:0051610
label: BiologicalProcess
name: Serotonin uptake
- id: MESH:D012701
label: ChemicalSubstance
name: Serotonin
- id: GO:0060096
label: BiologicalProcess
name: Serotonin secretion, neurotransmission
- id: MESH:D013313
label: Disease
name: Posttraumatic stress disorder
reference:
- https://go.drugbank.com/drugs/DB00715#BE0000749
- https://drugs.ncats.io/drug/41VRH5220H
- https://en.wikipedia.org/wiki/Post-traumatic_stress_disorder
48 changes: 1 addition & 47 deletions submission.yaml
Original file line number Diff line number Diff line change
@@ -1,47 +1 @@
- directed: true
graph:
disease: Posttraumatic stress disorder
disease_mesh: MESH:D013313
drug: paroxetine
drug_mesh: MESH:D017374
drugbank: DB:DB00715
links:
- key: decreases activity of
source: MESH:D017374
target: UniProt:P31645
- key: positively regulates
source: UniProt:P31645
target: GO:0051610
- key: decreases abundance of
source: GO:0051610
target: MESH:D012701
- key: positively correlated with
source: MESH:D012701
target: GO:0060096
- key: negatively correlated with
source: GO:0060096
target: MESH:D013313
multigraph: true
nodes:
- id: MESH:D017374
label: Drug
name: Paroxetine
- id: UniProt:P31645
label: Protein
name: Sodium-dependent serotonin transporter
- id: GO:0051610
label: BiologicalProcess
name: Serotonin uptake
- id: MESH:D012701
label: ChemicalSubstance
name: Serotonin
- id: GO:0060096
label: BiologicalProcess
name: Serotonin secretion, neurotransmission
- id: MESH:D013313
label: Disease
name: Posttraumatic stress disorder
reference:
- https://go.drugbank.com/drugs/DB00715#BE0000749
- https://drugs.ncats.io/drug/41VRH5220H
- https://en.wikipedia.org/wiki/Post-traumatic_stress_disorder

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