Merge pull request #1 from SuLab/master

Merge back to local

.github/ISSUE_TEMPLATE/new-drug-mechanism-indication.md

@@ -0,0 +1,64 @@
+---
+name: New drug mechanism indication
+about: The simplest way to suggest a new entry for DrugMechDB
+title: "[ADDITION]"
+labels: ''
+assignees: ''
+
+---
+
+Great, you'd like to suggest a new entry in DrugMechDB.  Thank you!
+
+First, two quick notes: 
+* If you are familiar with GitHub pull requests, please submit a pull request on [indication_paths.yaml](https://github.com/SuLab/DrugMechDB/blob/master/indication_paths.yaml)
+* If you don't know _all_ the information requested below, just fill in as much as you do know
+
+A new Drug Mechanism is composed of nodes and edges.  The nodes are the biomedical entities (genes, diseases, complexes, pathways, etc.), and the edges are the relationships between those nodes.  The starting node will always be a drug, and ending node will always be a disease.  **For example, the mechanism for acetaminophen's mechanism of action in treating pain would look like this**:
+
+Node 1:
+- name: acetaminophen
+- id: MESH:D000082
+- type: Drug
+
+Edge 1-2
+- relation: INHIBITS
+
+Node 2:
+- name: Cox-1
+- id: UniProt:P23219
+- type: Protein
+
+Edge 2-3
+- relation: PRODUCES
+
+Node 3:
+- name: Prostaglandins
+- id: MESH:D011453
+- type: Compound Class
+
+Edge 3-4
+- relation: CAUSES
+
+Node 4:
+- name: Pain
+- id: MESH:D010146
+- type: Disease
+
+Following that example, please fill out the template below.
+
+----- PLEASE DELETE EVERYTHING ABOVE THIS LINE PRIOR TO SUBMITTING -----
+
+Node 1
+- name: 
+- id: 
+- type: drug
+
+Edge 1-2
+- relation: 
+
+Node 2
+- name: 
+- id: 
+- type: 
+
+[add more nodes and edges, as needed]

README.md

@@ -14,6 +14,11 @@ However, there are usually more steps across a biological knowledge graph requir
 its mechanism to the reduction of a disease.  This database attempts to catalog a subset of known drug-disease indications
 as a path through a network of biomedical entities.
 
+Below is a visualized example of one entry in DrugMechDB - A path from Cortisone acetate to Keratitis.
+
+![Path Example](path.png)
+
+
 ## Curation
 
 Indications were selected at random from the set contained within DrugCentral. Half were taken from the full set,