Lithium + Cocaine

combos.json

@@ -980,6 +980,22 @@
       "note": "No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.",
       "status": "Caution"
     },
+    "lithium": {
+      "note": "Lithium may inhibit some of the recreational effects of cocaine.",
+      "sources": [
+        {
+          "author": "Flemenbaum, A.",
+          "title": "Antagonism of behavioral effects of cocaine by lithium. (1977)",
+          "url": "https://doi.org/10.1016/0091-3057(77)90015-6"
+        },
+        {
+          "author": "Cronson, A. J., & Flemenbaum, A.",
+          "title": "Antagonism of Cocaine Highs by Lithium. (1981)",
+          "url": "https://doi.org/10.1007/978-1-4684-3614-3_132"
+        }
+      ],
+      "status": "Low Risk & Decrease"
+    },
     "lsd": {
       "note": "Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences",
       "status": "Caution"
@@ -1810,6 +1826,22 @@
       ],
       "status": "Dangerous"
     },
+    "cocaine": {
+      "note": "Lithium may inhibit some of the recreational effects of cocaine.",
+      "sources": [
+        {
+          "author": "Flemenbaum, A.",
+          "title": "Antagonism of behavioral effects of cocaine by lithium. (1977)",
+          "url": "https://doi.org/10.1016/0091-3057(77)90015-6"
+        },
+        {
+          "author": "Cronson, A. J., & Flemenbaum, A.",
+          "title": "Antagonism of Cocaine Highs by Lithium. (1981)",
+          "url": "https://doi.org/10.1007/978-1-4684-3614-3_132"
+        }
+      ],
+      "status": "Low Risk & Decrease"
+    },
     "dmt": {
       "note": "There is a large number of reports indicating a high seizure and psychosis risk from this combination.",
       "sources": [

drugs.json

@@ -15266,6 +15266,22 @@
         "note": "No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.",
         "status": "Caution"
       },
+      "lithium": {
+        "note": "Lithium may inhibit some of the recreational effects of cocaine.",
+        "sources": [
+          {
+            "author": "Flemenbaum, A.",
+            "title": "Antagonism of behavioral effects of cocaine by lithium. (1977)",
+            "url": "https://doi.org/10.1016/0091-3057(77)90015-6"
+          },
+          {
+            "author": "Cronson, A. J., & Flemenbaum, A.",
+            "title": "Antagonism of Cocaine Highs by Lithium. (1981)",
+            "url": "https://doi.org/10.1007/978-1-4684-3614-3_132"
+          }
+        ],
+        "status": "Low Risk & Decrease"
+      },
       "lsd": {
         "note": "Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences",
         "status": "Caution"
@@ -23289,6 +23305,22 @@
         ],
         "status": "Dangerous"
       },
+      "cocaine": {
+        "note": "Lithium may inhibit some of the recreational effects of cocaine.",
+        "sources": [
+          {
+            "author": "Flemenbaum, A.",
+            "title": "Antagonism of behavioral effects of cocaine by lithium. (1977)",
+            "url": "https://doi.org/10.1016/0091-3057(77)90015-6"
+          },
+          {
+            "author": "Cronson, A. J., & Flemenbaum, A.",
+            "title": "Antagonism of Cocaine Highs by Lithium. (1981)",
+            "url": "https://doi.org/10.1007/978-1-4684-3614-3_132"
+          }
+        ],
+        "status": "Low Risk & Decrease"
+      },
       "dmt": {
         "note": "There is a large number of reports indicating a high seizure and psychosis risk from this combination.",
         "sources": [
@@ -25462,6 +25494,47 @@
           }
         ],
         "status": "Dangerous"
+      },
+      "dxm": {
+        "note": "Risk of serotonin syndrome as both drugs raise serotonin levels. In addition to concerns of high blood pressure and unnecessary strain on the heart. As well as potentially causing anxiety and greater physical discomfort due to the combination.",
+        "sources": [
+          {
+            "author": "J Kehr,  F Ichinose,  S Yoshitake,  M Goiny,  T Sievertsson,  F Nyberg,  T Yoshitake",
+            "title": "Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats",
+            "url": "https://doi.org/10.1111/j.1476-5381.2011.01499.x"
+          },
+          {
+            "author": "Gregory C. Hadlock, Katy M. Webb, Lisa M. McFadden, Pei Wen Chu, Jonathan D. Ellis, Scott C. Allen, David M. Andrenyak, Paula L. Vieira-Brock, Christopher L. German, Kevin M. Conrad, Amanda J. Hoonakker, James W. Gibb, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein",
+            "title": "4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse",
+            "url": "https://doi.org/10.1124/jpet.111.184119 "
+          },
+          {
+            "author": "Anna R. Schwartz, Anthony F. Pizon & Daniel E. Brooks",
+            "title": "Dextromethorphan-induced serotonin syndrome",
+            "url": "https://doi.org/10.1080/15563650701668625"
+          },
+          {
+            "author": "DrugBank",
+            "title": "Dextromethorphan",
+            "url": "https://go.drugbank.com/drugs/DB00514"
+          },
+          {
+            "author": "Henderson MG, Fuller RW",
+            "title": "Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats",
+            "url": "https://doi.org/10.1016/0006-8993(92)91144-4"
+          },
+          {
+            "author": "Reissig CJ, Carter LP, Johnson MW, Mintzer MZ, Klinedinst MA, Griffiths RR",
+            "title": "High doses of dextromethorphan, an NMDA antagonist, produce effects similar to classic hallucinogens ",
+            "url": "https://doi.org/10.1007/s00213-012-2680-6"
+          },
+          {
+            "author": "Meng H, Cao J, Kang J, Ying X, Ji J, Reynolds W, Rampe D.",
+            "title": "Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat ",
+            "url": "https://doi.org/10.1016/j.toxlet.2011.10.010"
+          }
+        ],
+        "status": "Dangerous"
       }
     },
     "formatted_aftereffects": {