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matplotlib histogram of nearest neighbor energies
closed in dev
enhancement
New feature or request
#255
opened Apr 4, 2024 by
dave-doty
allow subdomains to have multiple parents
enhancement
New feature or request
#252
opened Dec 15, 2023 by
dave-doty
generalized dependent domains
enhancement
New feature or request
#251
opened Dec 15, 2023 by
dave-doty
do not require This doesn't seem right
length
parameter to Domain
constructor when Domain.dependent
is True and subdomains are independent
invalid
#249
opened Dec 13, 2023 by
dave-doty
find/use/compare black box stochastic local search optimization software
#247
opened Nov 6, 2023 by
dave-doty
RNAplex output missing lines with sufficiently long input
bug
Something isn't working
#244
opened Oct 8, 2023 by
dave-doty
use New feature or request
_normalize_domains_pairs_disjoint_parameters
and _normalize_strands_pairs_disjoint_parameters
enhancement
#241
opened Sep 19, 2023 by
dave-doty
prevent two strands with the same name
bug
Something isn't working
#228
opened Sep 30, 2022 by
dave-doty
remove declaration of private properties in classes
invalid
This doesn't seem right
#210
opened Jul 21, 2022 by
dave-doty
store New feature or request
StrandPair
instead of Tuple[Strand, Strand]
in ConstraintWithStrandPairs
and make _determine_strand_pairs_to_check
more efficient
enhancement
#209
opened Jul 21, 2022 by
dave-doty
dependent domains whose independent source is fixed should be fixed
high priority
invalid
This doesn't seem right
#208
opened Jul 20, 2022 by
dave-doty
Allow inclusion of other arguments in New feature or request
description
for constraints.
enhancement
#195
opened Jul 4, 2022 by
cgevans
simplify API of This doesn't seem right
evaluate
function in constraint
high priority
invalid
#148
opened Dec 1, 2021 by
dave-doty
create tool that allows design to be specified and pre-packaged constraints to be picked without writing Python code
enhancement
New feature or request
#147
opened Nov 28, 2021 by
dave-doty
profile parallelism to see if speedups can be obtained
enhancement
New feature or request
#132
opened Oct 12, 2021 by
dave-doty
add RNA parameter to pfunc and pre-packaged constraints
enhancement
New feature or request
#126
opened Sep 14, 2021 by
dave-doty
allow quit early optimization even when there is positive probability to keep a higher-scoring change
enhancement
New feature or request
#124
opened Sep 14, 2021 by
dave-doty
add tutorial
documentation
Improvements or additions to documentation
high priority
#120
opened Sep 13, 2021 by
dave-doty
incorporate O(n^2) time vectorized RNAduplex replacement for sequence pairs
enhancement
New feature or request
#89
opened Aug 23, 2021 by
dave-doty
make independent fields private for Design/Strand/Domain, so that derived fields can be consistently recomputed by setters
bug
Something isn't working
high priority
#78
opened Aug 18, 2021 by
dave-doty
Check complex base pair probability in relation to other strands not part of the complex
enhancement
New feature or request
#32
opened Apr 7, 2021 by
UnHumbleBen
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