--- re-building ‘bugphyzz.Rmd’ using rmarkdown

processing vignette 'bugphyzz.Rmd' failed with diagnostics:

Vignette re-building failed.

Failed to install 'bugphyzz' from local:

Process completed with exit code 1.

No such keg: /opt/homebrew/Cellar/r

Node.js 16 actions are deprecated. Please update the following actions to use Node.js 20: actions/checkout@v3, actions/cache@v3. For more information see: https://github.blog/changelog/2023-09-22-github-actions-transitioning-from-node-16-to-node-20/.

unable to access index for repository https://bioconductor.org/packages/3.19/bioc/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/data/annotation/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/data/experiment/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/workflows/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/books/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://cran.rstudio.com/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/bioc/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/data/annotation/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/data/experiment/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/workflows/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/books/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://cran.rstudio.com/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/bioc/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/data/annotation/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/data/experiment/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/workflows/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://cran.rstudio.com/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://cran.rstudio.com/bin/macosx/big-sur-arm64/contrib/4.5:

harfbuzz 8.4.0 is already installed and up-to-date. To reinstall 8.4.0, run: brew reinstall harfbuzz

macOS's Gatekeeper has been disabled for this Cask

pkg-config 0.29.2_3 is already installed and up-to-date. To reinstall 0.29.2_3, run: brew reinstall pkg-config

HOMEBREW_NO_INSTALLED_DEPENDENTS_CHECK is set: not checking for outdated dependents or dependents with broken linkage!

unable to access index for repository https://bioconductor.org/packages/3.19/bioc/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/data/annotation/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/data/experiment/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/workflows/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/books/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://cran.rstudio.com/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/bioc/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/data/annotation/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/data/experiment/bin/macosx/big-sur-arm64/contrib/4.5:

unable to access index for repository https://bioconductor.org/packages/3.19/workflows/bin/macosx/big-sur-arm64/contrib/4.5: